Energy & Fatigue
How tired you feel, which is separate from how well you perform. It is measured on fatigue questionnaires, and a change here can happen with no change in any physical test.
159 supplements analyzed and ranked by clinical evidence.
Supplement Evidence
Metabolic/oxidative protection
Mitochondrial +30 copies
Fat oxidation + ketones
Muscle strength + VO2max
Riboflavin status, +83%
Fatigue/function, -25 pts
Fatigue ↓, endurance ↑
+3.2 min endurance
Fatigue ↓, cognition ↑
Exercise capacity ↑, fatigue ↓
Biomarkers improved, fatigue ↓
Fuel shift: FFA↓, carbs↑
NAD+ boost: ~2x
NAD+↑, fatigue↓
Exercise tolerance↑, fatigue↓
Energy up; fatigue down
VO2↑, lactate↓
Fatigue ↓, endurance ↑
VO2max/lactate better
Fatigue ↓, appetite ↑
Less fatigue, better endurance
Reduced damage, faster recovery
Sleep/Fatigue: better sleep, less fatigue
Performance: faster recovery, energy
Energy/fatigue +50 pts
ATP recovery +53 s
Fatigue improved, QoL +50
Exercise tolerance +53s
Energy/fatigue: TTE +1.28
Energy/fatigue: REE +12.4%
Energy/fatigue: sleep +3%
Better glycemia, +1.76% HbA1c
Lipids improved in subgroups
Energy/Fatigue: biotin support
Energy/Fatigue: deficiency −54%
Alertness/attention +accuracy
Fatigue/stress - sAA, +sleep
Alertness, less fatigue
Reaction time, +15–20 ms
Energy/fatigue: +VO2, time-to-fatigue
Energy/fatigue: ↓MDA, ↑SOD/GSH
Energy/fatigue: +32% TE
Fatigue/cognition: GABAB + plasticity
Pain/inflammation: reduced pain, IL-6
Endurance +36%
Reps +10–21%
Power +5%; NO↑
Soreness −40%; reps +53%
BP↓; cycling efficiency↑