Danshen
17 benefits mapped to clinical evidence across supplements.
Dose per serving from research
12 study groups in 8 studies say how much Danshen participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 g to 2.5 g, 58% of 12 study groups.
| Daily dose | Study groups |
|---|---|
| 500 mg or less | 1 |
| 500 mg to 1 g | 3 |
| 1 g to 2.5 g | 7 |
| 2.5 g to 5 g | 1 |
Benefit Evidence
Circulation, ischemia +
Endothelial function, BP
Blood flow, viscosity
Angina relief, +25pp
Endothelial/arterial function, -46%
Lower heart injury markers, -26%
Antioxidant balance, injury markers
Immune/clinical recovery, less injury
Inflammation ↓ hs-CRP -6.8%
Cytokines ↓ TNF-α/IL-6
Endothelial/oxidative ↓
Better oxygenation (+PaO2)
Less breathlessness; fewer exacerbations
Angina relief, +25pp
Endothelial/arterial function, -46%
Lower heart injury markers, -26%
Research sources
Blood circulation (34)
- [Effect of compound Salvia injection on blood coagulation in patients with traumatic cerebral infarction]
PubMed ID: 15553818
Compound Salvia injection reduced coagulation/activation markers (P‑selectin, vWF, D‑dimer), supporting improved blood rheology/blood flow.
- Salvia miltiorrhiza adjuvant therapy facilitates cardiac function recovery in patients with myocardial infarction
PubMed ID: 40089929
Post‑MI improvements in CO, CI and SV imply better macrocirculatory performance and blood flow.
- Effects of Dan Shen (Salvia miltiorrhiza) on blood pressure management in hypertensive patients: a randomized controlled trial
PubMed ID: 40658027
Lower ambulatory BP and improved hemodynamic/metabolic measures indicate improved vascular function and perfusion.
- Effect of Compound Danshen Injection Combined with Magnesium Sulfate on Oxidative Stress, TNF-α, NO, and Therapeutic Efficacy in Severe Preeclampsia
PubMed ID: 35898773
Compound Danshen increased NO and improved BP control in preeclampsia, consistent with enhanced endothelial‑mediated blood flow.
- Clinical effectiveness and safety of salvia miltiorrhiza depside salt combined with aspirin in patients with stable angina pectoris: A multicenter, pragmatic, randomized controlled trial
PubMed ID: 33360345
SMDS increased TEG AA% sensitivity (platelet function/aspirin responsiveness), indicating an effect on thrombotic/flow parameters.
- Hot Compress with Chinese Herbal Salt Packets Reducing PICC Catheter Complications: A Randomized Controlled Trial
PubMed ID: 29946873
Herbal hot compress including Danshen increased vein diameter and first-attempt PICC success — direct practical improvement in peripheral circulation.
- The Effects of Iontophoretic Injections of Salvia miltiorrhiza on the Maturation of the Arteriovenous Fistula: A Randomized, Controlled Trial
PubMed ID: 27622956
Markedly higher AVF maturation rate, flow and diameter after topical/iontophoretic Salvia — direct improvement in local circulation.
- A randomized placebo controlled trial of an innovative herbal formula in the prevention of atherosclerosis in postmenopausal women with borderline hypercholesterolemia
PubMed ID: 24906587
LDL/TC reduction and carotid IMT regression over 12 months indicate improved vascular health and circulation long-term.
- Effect of Salvia miltiorrhiza hydrophilic extract on the endothelial biomarkers in diabetic patients with chronic artery disease
PubMed ID: 22318996
Reduced endothelial activation (sVCAM-1, vWF) and oxLDL in coronary patients supports improved vascular function and blood flow.
- Effect of Salvia miltiorrhiza hydrophilic extract on antioxidant enzymes in diabetic patients with chronic heart disease: a randomized controlled trial
PubMed ID: 21544882
Oxidative stress reductions in chronic heart disease patients support vascular/endothelial health and blood flow indirectly.
- A randomized, double-blind, placebo-controlled study to evaluate the efficacy and tolerability of Fufang Danshen (Salvia miltiorrhiza) as add-on antihypertensive therapy in Taiwanese patients with uncontrolled hypertension
PubMed ID: 21887804
Add‑on Fufang Danshen lowered systolic BP and pulse and increased BP control—improves hemodynamics and perfusion.
- [Effect of depsides salts from salvia miltiorrhiza on functions of platelet and vascular endothelial cell of patients with chronic obstructive pulmonary disease in acute exacerbation stage]
PubMed ID: 20519076
Reduced platelet/endothelial activation markers in COPD exacerbations supports improved vascular status.
- [Effect of compound Danshen Dripping Pill on carotid arterial intima-media in patients with type 2 diabetes mellitus]
PubMed ID: 21038652
Longer-term data in diabetic patients (and subgroup antioxidant data) indicate modest circulation benefits in some groups.
- Randomized clinical trial of Chinese herbal medications to reduce wound complications after mastectomy for breast carcinoma
PubMed ID: 20862715
IV Salvia reduced skin‑flap ischemia/necrosis after mastectomy—direct improvement in local tissue perfusion.
- [Investigation on treatment of fetal growth restriction by salvia injection combined with composite amino acid]
PubMed ID: 19338158
Salvia injections improved umbilical artery S/D ratio and fetal blood flow in growth‑restricted pregnancies (direct circulatory effect).
- Clinical observation of Danhong Injection (herbal TCM product from Radix Salviae miltiorrhizae and Flos Carthami tinctorii) in the treatment of traumatic intracranial hematoma
PubMed ID: 19427180
Danhong (contains Danshen) accelerated hematoma absorption and reduced coagulation markers—implies improved cerebral microcirculation.
- The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients
PubMed ID: 19388864
Danshen+Pueraria improved brachial FMD and reduced carotid IMT—strong evidence for improved systemic circulation/endothelial function.
- Sulfotanshinone Sodium Injection could decrease fibrinogen level and improve clinical outcomes in patients with unstable angina pectoris
PubMed ID: 18790543
Sulfotanshinone + aspirin reduced fibrinogen and improved angina outcomes, indicating improved haemostasis and blood flow.
- [Randomized and controlled research of Chinese drug acupoint injection therapy for erectile dysfunction]
PubMed ID: 18271227
Acupoint Danshen injections improved erectile function and penile PSV—direct evidence of improved local blood flow.
- Effects of replenishing qi, promoting blood circulation and resolving phlegm on vascular endothelial function and blood coagulation system in senile patients with hyperlipemia
PubMed ID: 16817277
Danshen Jueming decreased TC/LDL and fibrinogen/coagulation markers in hyperlipidemic elderly—favourable for blood flow and endothelial health.
- [Comparative study of composite danshen droplet pills and sordi in treatment of patients with chronic stable angina]
PubMed ID: 9812646
Composite Danshen pills improved exercise tolerance and ischemic thresholds in angina, consistent with improved myocardial perfusion/blood flow.
- [Effect of compound salvia injection on nitrate ester tolerance]
PubMed ID: 15719745
Compound Salvia injection markedly reduced nitrate tolerance and improved endothelial-dependent vasodilation and eNOS expression.
- [Salvia Miltiorrhiza reduces plasma levels of asymmetric ADMA in patients with non-ST elevation myocardial infarction undergoing percutaneous coronary intervention]
PubMed ID: 25632741
Post-PCI study showed larger reductions in ADMA with Salvia miltiorrhiza, indicating improved endothelial function and blood flow.
- Synergistic Effects of Sanghuang⁻Danshen Bioactives on Arterial Stiffness in a Randomized Clinical Trial of Healthy Smokers: An Integrative Approach to in silico Network Analysis
PubMed ID: 30621047
Sanghuang–Danshen product decreased arterial stiffness and systolic BP and increased eNOS phosphorylation (mechanistic vascular effect; combination product).
- [Influence of Salvia miltiorrhizae and Astragalus membranaceus on hemodynamics and liver fibrosis indexes in liver cirrhotic patients with portal hypertension]
PubMed ID: 12577420
Salvia + Astragalus improved portal hemodynamics and reduced portal pressure/fibrosis markers in cirrhosis (portal circulation improvement).
- [Effect of danshen chuanxiongqin injection on the myocardial damage of unstable angina patients undergoing percutaneous coronary intervention]
PubMed ID: 21866658
Pre-PCI Danshen–Chuanxiong reduced platelet activation (P-selectin) and myocardial injury markers, supporting improved flow and reduced microthrombi.
- [Effect of huoxue tablet on the rheology of erythrocyte in primary hypertension]
PubMed ID: 10322817
Huoxue tablet (with Danshen) improved erythrocyte deformability and reduced aggregation/viscosity, directly improving blood flow.
- [Effect of composite salviae dropping pill on endothelin gene expression in circulating endothelial cells of patients with coronary heart disease]
PubMed ID: 11783243
Composite Salvia dropping pill reduced endothelin-1 gene expression in endothelial cells, favoring vasodilation/flow.
- [Observation of preventing and treating effect of Salvia miltiorrhiza composita on patients with ischemic coronary heart disease undergoing non-heart surgery]
PubMed ID: 11783299
Perioperative IV Salvia reduced ECG ischemia and stabilized heart rate, indirectly supporting organ perfusion.
- [Observation on effect of integrated Chinese and Western medicine in treating patients with peripheral atherosclerosis obliterans]
PubMed ID: 11783195
Salvia + PGE1 in PAD improved endothelin/NO and apoproteins with clinical vascular symptom benefits.
- [Effect of Composite Salviae Dropping Pill on function of platelet activation in patients with unstable angina pectoris]
PubMed ID: 11789221
Composite Salvia pill reduced platelet activation marker GMP-140, which supports microcirculatory flow.
- [Effect of tongxinluo capsule on plasma endothelin and calcitonin gene related peptide in patients with unstable angina pectoris]
PubMed ID: 12585189
Composite Danshen tablet altered endothelin/CGRP in unstable angina, consistent with vasoactive improvements.
- [Study on clinical therapeutic effect of composite Salvia injection matched with Western medicine in treating diabetic foot]
PubMed ID: 14626181
Composite Salvia injection improved blood viscosity and nerve conduction in diabetic foot patients, implying hemorheologic/blood flow improvements.
- [Observation on effect of compound danshen droplet-pill combined with trimetazidine in treating senile unstable angina pectoris]
PubMed ID: 16248238
Clinical reduction in angina and arrhythmia suggests improved myocardial perfusion and blood‑flow related benefits.
Heart health (30)
- [Effect of compound salvia injection on nitrate ester tolerance]
PubMed ID: 15719745
Compound Salvia injection reduced nitrate tolerance and improved endothelial markers (eNOS), relevant to cardiac pharmacology.
- [Salvia Miltiorrhiza reduces plasma levels of asymmetric ADMA in patients with non-ST elevation myocardial infarction undergoing percutaneous coronary intervention]
PubMed ID: 25632741
Post-PCI addition of Salvia miltiorrhiza led to greater ADMA decrease, indicating improved endothelial function relevant to heart health.
- Synergistic Effects of Sanghuang⁻Danshen Bioactives on Arterial Stiffness in a Randomized Clinical Trial of Healthy Smokers: An Integrative Approach to in silico Network Analysis
PubMed ID: 30621047
Sanghuang–Danshen product lowered arterial stiffness and BP and increased eNOS phosphorylation — strong cardiovascular support (combination product).
- [Effects of yiqi huoxue method on cardiac function in patients with congestive heart failure]
PubMed ID: 16841677
Combined TCM regimen (likely including blood-activating herbs) improved overall response/cardiac function in heart failure; Danshen contribution plausible but not isolated.
- [Salvia miltiorrhizae in the treatment of the viral myocarditis]
PubMed ID: 1421975
In pediatric viral myocarditis adding Salvia reduced oxidative injury markers and improved cardiac enzyme/ECG recovery.
- [Effect of danshen chuanxiongqin injection on the myocardial damage of unstable angina patients undergoing percutaneous coronary intervention]
PubMed ID: 21866658
Pre-PCI Danshen–Chuanxiong lowered platelet activation and CK-MB/troponin I after PCI, supporting cardioprotection.
- [Effect of xinmaitong capsule on damage of lipid peroxidation in coronary heart disease patients with myocardial ischemia]
PubMed ID: 9863127
Ischemic heart disease study with Danshen-containing product improved oxidative markers and symptoms.
- [Observation of preventing and treating effect of Salvia miltiorrhiza composita on patients with ischemic coronary heart disease undergoing non-heart surgery]
PubMed ID: 11783299
Intravenous Salvia improved ECG ischemia outcomes and heart-rate stability during noncardiac surgery.
- [Observation on effect of integrated Chinese and Western medicine in treating patients with peripheral atherosclerosis obliterans]
PubMed ID: 11783195
Salvia + prostaglandin improved vascular markers in PAD; indirect support for cardiovascular benefit.
- [Effect of Composite Salviae Dropping Pill on function of platelet activation in patients with unstable angina pectoris]
PubMed ID: 11789221
Composite Salvia pill with aspirin reduced platelet activation marker (GMP-140) and angina symptoms.
- [Effect of tongxinluo capsule on plasma endothelin and calcitonin gene related peptide in patients with unstable angina pectoris]
PubMed ID: 12585189
Composite Danshen tablet changed endothelin/CGRP in unstable angina, indicating vasoactive cardiac effects.
- [Effect of combined therapy of shenmai and compound danshen injection on myocardial reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction]
PubMed ID: 15250199
Shenmai + compound Danshen improved early LV performance and reduced oxidative/inflammatory markers after PCI/AMI.
- [Observation on effect of compound danshen droplet-pill combined with trimetazidine in treating senile unstable angina pectoris]
PubMed ID: 16248238
Compound Danshen + trimetazidine significantly reduced angina attacks, arrhythmias and MI/sudden death versus control (clear cardioprotective clinical benefit).
- Clinical non-inferiority trial on treatment of coronary heart disease angina pectoris of Xin-blood stasis syndrome type with lyophilized Salvia salt of lithospermic acid powder for injection
PubMed ID: 16571277
Lithospermic-acid product (Salvia derivative) showed superior clinical efficacy to Danshen injection for angina, supporting anti‑anginal/heart benefits from Salvia compounds.
- Sulfotanshinone Sodium Injection could decrease fibrinogen level and improve clinical outcomes in patients with unstable angina pectoris
PubMed ID: 18790543
Sulfotanshinone (Salvia derivative) + aspirin reduced fibrinogen and improved angina outcomes versus aspirin alone, indicating anti‑ischaemic/antithrombotic cardiac benefit.
- The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients
PubMed ID: 19388864
Danshen+Pueraria improved endothelial function and carotid IMT in coronary patients, supportive of cardiovascular benefit.
- [Effect of compound Danshen Dripping Pill on carotid arterial intima-media in patients with type 2 diabetes mellitus]
PubMed ID: 21038652
Long antioxidant trial including Salvia showed no overall hypertension benefit but some subgroup signals; cardioprotective attribution uncertain (low‑moderate).
- [Effect of compound danshen dripping pill on arterial intima-media thickness in patients with newly diagnosed type 2 diabetes mellitus]
PubMed ID: 21302487
Compound Danshen improved glycemic and lipid measures and slowed IMT progression in T2DM—benefits relevant to long‑term cardiac risk reduction.
- A randomized, double-blind, placebo-controlled study to evaluate the efficacy and tolerability of Fufang Danshen (Salvia miltiorrhiza) as add-on antihypertensive therapy in Taiwanese patients with uncontrolled hypertension
PubMed ID: 21887804
Fufang Danshen added to antihypertensive therapy produced clinically meaningful systolic BP reduction and better BP control rates (cardiovascular benefit).
- Effect of Salvia miltiorrhiza hydrophilic extract on antioxidant enzymes in diabetic patients with chronic heart disease: a randomized controlled trial
PubMed ID: 21544882
In diabetic patients with chronic heart disease, reduced oxidative stress markers and increased antioxidant enzymes — supportive of cardiac health.
- Effects of Dan Shen (Salvia miltiorrhiza) on blood pressure management in hypertensive patients: a randomized controlled trial
PubMed ID: 40658027
Large RCT showed intravenous Salvia reduced ambulatory BP and improved QoL/metabolic markers in hypertensive patients (cardiovascular support).
- Salvia miltiorrhiza adjuvant therapy facilitates cardiac function recovery in patients with myocardial infarction
PubMed ID: 40089929
Adjunctive Salvia injection after MI significantly improved LVEF, ventricular dimensions and hemodynamic indices (strong cardiac functional benefit reported).
- Guanxin Danshen Dripping Pills Improve Quality of Life and Cardiovascular Prognoses of CHD Patients after PCI with Anxiety or Depression (GLAD Study): A Randomized Double-Blind Placebo-Controlled Study
PubMed ID: 36301456
GXDS improved angina symptoms, QoL and biomarkers post‑PCI in CHD patients, indicating cardiac benefit.
- Comparative effectiveness of Di'ao Xin Xue Kang capsule and Compound Danshen tablet in patients with symptomatic chronic stable angina
PubMed ID: 25394847
Compound Danshen improved angina symptoms and QoL measures in chronic stable angina (modest clinical effect; inferior to comparator).
- A randomized placebo controlled trial of an innovative herbal formula in the prevention of atherosclerosis in postmenopausal women with borderline hypercholesterolemia
PubMed ID: 24906587
Danshen+Gegen formula modestly lowered LDL/TC and reduced carotid IMT over 12 months — cardiovascular risk reduction relevant to heart support.
- Effect of Salvia miltiorrhiza hydrophilic extract on the endothelial biomarkers in diabetic patients with chronic artery disease
PubMed ID: 22318996
Reduced endothelial activation and oxLDL in coronary disease patients — vascular support relevant to heart health.
- [Observation on therapeutic effects of electroacupuncture at Neiguan (PC 6) on silent myocardial ischemia]
PubMed ID: 21823276
Compound Danshen reduced heart rate, BP and ischemic episodes in silent myocardial ischemia vs baseline (less effective than acupuncture) — symptomatic cardiac benefit.
- [Myocardial protection of cardioplegic solution with Salvia miltiorrhizae in extracorporeal circulation of coronary artery bypass graft]
PubMed ID: 22097198
Also reduced perioperative cardiac enzymes (CK‑MB/cTnI) — further direct cardiac protection signal.
- [Comparative study of composite danshen droplet pills and sordi in treatment of patients with chronic stable angina]
PubMed ID: 9812646
Composite Danshen pills improved exercise tolerance and stress-induced ischemia in stable angina patients.
- [Trial study on DENG Tie-tao's coronary heart disease capsules in improving patients' quality of life]
PubMed ID: 16181529
Danshen-containing coronary capsule reduced nitroglycerine use and improved QoL in stable angina, supporting cardiac benefit.
Cell health (22)
- Forty-six cases of acute cerebral infarction treated with the combined use of acupuncture and drugs
PubMed ID: 18246677
Acupuncture + Danshen injection improved oxidative stress markers after cerebral infarction, implying cellular protection in ischemic brain.
- The protective effects of the traditional Chinese herbs against renal damage induced by extracorporeal shock wave lithotripsy: a clinical study
PubMed ID: 20607528
Preserved SOD and reduced injury markers after ESWL in treated group indicates tubular/cellular protection.
- Effectiveness of Radix astragali and Salvia miltiorrhiza injection in treatment of skeletal muscle injury of aerobics athletes
PubMed ID: 30203777
Large athletic injury trial showed greater improvements in SOD/MDA and muscle enzymes, supporting cellular protection.
- [Salvia miltiorrhizae in the treatment of the viral myocarditis]
PubMed ID: 1421975
In viral myocarditis children, added Salvia reduced lipid peroxide and membrane viscosity, consistent with cellular protection.
- [Observation of therapeutic effect of Salviae miltiorrhiza and cytosine diphosphate-choline injection on patients with hypertensive cerebral hemorrhage]
PubMed ID: 11783323
Improved clinical/hematoma resolution in cerebral hemorrhage implies tissue-protective effects in brain cells.
- [Clinical observation of compound salvia injection in treating mid-severe infantile hypoxic-ischemic encephalopathy]
PubMed ID: 12575591
Infant HIE study showed reduced biochemical markers of brain injury, consistent with cellular protection.
- [Effect of radix Salviae miltiorrhizae on production of free radical products from lung during cardiopulmonary bypass operation]
PubMed ID: 9387742
Reduced lung free radical production and leukocyte aggregation during CPB indicates cellular/oxidative protection.
- [Effect of salvia miltiorrhiza composita on superoxide dismutase and malonyldialdehyde in treating patients with non-insulin dependent diabetes mellitus (NIDDM)]
PubMed ID: 9812649
Restored antioxidant enzymes (SOD) and reduced MDA in T2DM patients implying cellular oxidative protection.
- [Effect of xinmaitong capsule on damage of lipid peroxidation in coronary heart disease patients with myocardial ischemia]
PubMed ID: 9863127
Formulation with Danshen improved SOD/MDA in myocardial ischemia patients, implying cellular antioxidant protection.
- [Observation of preventing and treating effect of Salvia miltiorrhiza composita on patients with ischemic coronary heart disease undergoing non-heart surgery]
PubMed ID: 11783299
Improved ECG ischemia endpoints and heart-rate stability during surgery imply myocardial cellular protection.
- [The effect of salvia miltiorrhiza and shengmai on inflammatory mediator and renal function of post-operative patients with obstructive jaundice]
PubMed ID: 12528557
Post-op reductions in inflammatory mediators and renal markers suggest organ/cellular protective effects.
- [Clinical study on effect and therapeutical mechanism of composite Salvia injection on acute cerebral infarction]
PubMed ID: 12584834
Composite Salvia reduced LPO and increased SOD in acute stroke patients, consistent with cellular antioxidant protection.
- [Effect of danshao granule on serum superoxide dismutase activity and malonyldialdehyde content in children with Henoch-Schonlein purpura nephritis]
PubMed ID: 14714360
Improved SOD/MDA and reduced proteinuria in HSP nephritis suggests reduction in oxidative cellular injury.
- Immunomodulatory effects of yun zhi and danshen capsules in health subjects--a randomized, double-blind, placebo-controlled, crossover study
PubMed ID: 14996412
Enhancement of cell-mediated immunity and CD4 counts implies improved cellular resilience/function.
- [Effect of combined therapy of shenmai and compound danshen injection on myocardial reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction]
PubMed ID: 15250199
Shenmai + compound Danshen reduced MDA/inflammatory cytokines and improved early LV function, indicating cellular protection.
- [Effects of Salvia miltiorrhiza on oxidative stress and microinflammatory state in patients undergoing continuous hemodialysis]
PubMed ID: 17058827
Reduced oxidative-protein products and MDA and increased SOD in dialysis patients indicate cellular oxidative protection.
- [Effects of Salvia miltiorrhiza on serum levels of inflammatory cytokines in patients with severe acute pancreatitis]
PubMed ID: 17214932
Adjunct Salvia decreased pro-inflammatory cytokines (IL‑6, IL‑8, TNF‑α) in pancreatitis, consistent with reduced cellular inflammatory injury.
- Effect of Salvia miltiorrhiza hydrophilic extract on antioxidant enzymes in diabetic patients with chronic heart disease: a randomized controlled trial
PubMed ID: 21544882
Randomized trial showed marked reductions in MDA and increases in GSH and SOD — strong direct antioxidant/cellular protection biomarker evidence.
- [Myocardial protection of cardioplegic solution with Salvia miltiorrhizae in extracorporeal circulation of coronary artery bypass graft]
PubMed ID: 22097198
Perioperative use with CABG reduced oxidative markers and cardiac enzymes — direct myocardial cellular protection signal.
- Effect of Salvia miltiorrhiza hydrophilic extract on the endothelial biomarkers in diabetic patients with chronic artery disease
PubMed ID: 22318996
Reduced oxidized LDL and endothelial activation markers in coronary patients — vascular cellular protection evidence.
- The effect of somatostatin, ulinastatin and Salvia miltiorrhiza on severe acute pancreatitis treatment
PubMed ID: 23514667
Added to pancreatitis regimens decreased proinflammatory cytokines (TNF-α, IL-6) and increased IL-10 — supports reduced inflammatory cellular injury.
- Effect of Salvia Miltiorrhiza Polyphenolic Acid Injection on Improving Limb Use and Cognitive Impairment in Patients with Acute Stroke
PubMed ID: 35983530
Salvianolic acid injection was associated with reduced infarct volume and lower neuronal injury biomarkers (NSE, S100β) suggesting cellular/neuroprotection.
Antioxidant (17)
- [Myocardial protection of cardioplegic solution with Salvia miltiorrhizae in extracorporeal circulation of coronary artery bypass graft]
PubMed ID: 22097198
Reduced perioperative MDA and higher SOD vs control — strong antioxidant protection in cardiac surgery setting.
- Effect of Salvia miltiorrhiza hydrophilic extract on the endothelial biomarkers in diabetic patients with chronic artery disease
PubMed ID: 22318996
Oxidized LDL and endothelial activation marker reductions support antioxidant/anti-oxidative-stress effects.
- The effect of somatostatin, ulinastatin and Salvia miltiorrhiza on severe acute pancreatitis treatment
PubMed ID: 23514667
Inflammatory cytokine reductions (TNF-α, IL-6) and increased IL-10 are consistent with reduced oxidative/inflammatory stress.
- The protective effects of the traditional Chinese herbs against renal damage induced by extracorporeal shock wave lithotripsy: a clinical study
PubMed ID: 20607528
Preservation of SOD and lower injury markers after ESWL indicates antioxidant/anti-injury effect (multi-herb prep including Danshen).
- Effectiveness of Radix astragali and Salvia miltiorrhiza injection in treatment of skeletal muscle injury of aerobics athletes
PubMed ID: 30203777
Large RCT in athletes showed improvements in SOD and reductions in MDA with Astragalus+Danshen injection.
- [Salvia miltiorrhizae in the treatment of the viral myocarditis]
PubMed ID: 1421975
Older pediatric myocarditis trial reported decreased lipid peroxide and related oxidative improvements with Salvia.
- [Effect of Salvia miltiorrhiza on lipid peroxidation antioxidant enzymes activity in patients with chronic cor pulmonale]
PubMed ID: 7841755
Improved GSH-Px and catalase with decreased LPO in chronic cor pulmonale indicate antioxidant benefit.
- [Effect of radix Salviae miltiorrhizae on production of free radical products from lung during cardiopulmonary bypass operation]
PubMed ID: 9387742
Reduced lung peroxidation products during CPB demonstrates antioxidant activity of Radix Salviae in perioperative setting.
- [Effect of xinmaitong capsule on damage of lipid peroxidation in coronary heart disease patients with myocardial ischemia]
PubMed ID: 9863127
Formulation containing Danshen increased SOD and decreased MDA in ischemic heart disease patients.
- [Effect of salvia miltiorrhiza composita on superoxide dismutase and malonyldialdehyde in treating patients with non-insulin dependent diabetes mellitus (NIDDM)]
PubMed ID: 9812649
Restoration of SOD and reduction of MDA in T2DM patients is direct evidence of antioxidant effects.
- [Clinical study on effect and therapeutical mechanism of composite Salvia injection on acute cerebral infarction]
PubMed ID: 12584834
Composite Salvia decreased LPO and increased SOD in acute ischemic stroke—clear antioxidant evidence.
- [Effect of danshao granule on serum superoxide dismutase activity and malonyldialdehyde content in children with Henoch-Schonlein purpura nephritis]
PubMed ID: 14714360
Danshao improved SOD and lowered MDA in pediatric HSP nephritis, supporting antioxidant activity.
- [Effect of combined therapy of shenmai and compound danshen injection on myocardial reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction]
PubMed ID: 15250199
MDA and SOD changes after PCI show strong antioxidant activity when combined with Shenmai.
- [Effects of Salvia miltiorrhiza on oxidative stress and microinflammatory state in patients undergoing continuous hemodialysis]
PubMed ID: 17058827
Clear improvements in oxidative-stress biomarkers (AOPP, MDA decreased; SOD increased) in dialysis patients after Salvia treatment.
- [Effects of Salvia miltiorrhiza on serum levels of inflammatory cytokines in patients with severe acute pancreatitis]
PubMed ID: 17214932
Reduction in inflammatory cytokines in severe acute pancreatitis is consistent with reduced oxidative/inflammatory stress.
- Forty-six cases of acute cerebral infarction treated with the combined use of acupuncture and drugs
PubMed ID: 18246677
Acupuncture + Danshen injection led to increased SOD/GSH‑px and decreased MDA/NO after acute cerebral infarction (antioxidant effect).
- Effect of Salvia miltiorrhiza hydrophilic extract on antioxidant enzymes in diabetic patients with chronic heart disease: a randomized controlled trial
PubMed ID: 21544882
Clear RCT biomarker evidence: decreased MDA and increased GSH and SOD — direct antioxidant protection.
Inflammation (15)
- [The effect of salvia miltiorrhiza and shengmai on inflammatory mediator and renal function of post-operative patients with obstructive jaundice]
PubMed ID: 12528557
Combined Salvia + shengmai markedly reduced TNF-α, IL-6, IL-8 and endothelin postoperatively—strong anti-inflammatory signal.
- [Clinical study on effect and therapeutical mechanism of composite Salvia injection on acute cerebral infarction]
PubMed ID: 12584834
Composite Salvia decreased oxidative/inflammatory stress markers in acute ischemic stroke.
- [Effect of combined therapy of shenmai and compound danshen injection on myocardial reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction]
PubMed ID: 15250199
Shenmai + compound Danshen led to earlier decreases in IL-6 and TNF-α after PCI.
- [Effects of Salvia miltiorrhiza on oxidative stress and microinflammatory state in patients undergoing continuous hemodialysis]
PubMed ID: 17058827
Reduction in oxidative-stress markers in dialysis patients often accompanies lower inflammatory activity.
- [Effects of Salvia miltiorrhiza on serum levels of inflammatory cytokines in patients with severe acute pancreatitis]
PubMed ID: 17214932
Salvia adjunct produced a notably greater decline in IL‑6, IL‑8 and TNF‑α in severe acute pancreatitis—direct anti‑inflammatory evidence.
- [Therapeutic effect of the combination of traditional Chinese medicine and western medicine on patients with oral submucous fibrosis]
PubMed ID: 20448359
Danshen + prednisolone reduced lesion area and steroid side effects in oral submucous fibrosis, consistent with anti‑inflammatory tissue effects.
- Effect of Salvia miltiorrhiza hydrophilic extract on the endothelial biomarkers in diabetic patients with chronic artery disease
PubMed ID: 22318996
Decreased endothelial activation markers and oxLDL reflect reduced vascular inflammation.
- The effect of somatostatin, ulinastatin and Salvia miltiorrhiza on severe acute pancreatitis treatment
PubMed ID: 23514667
Randomized study in severe acute pancreatitis found significant decreases in TNF-α and IL-6 and increases in IL-10 with S. miltiorrhiza — strong anti-inflammatory signal.
- [Effects of "reinforcing Qi and activating blood" on stable chronic obstructive pulmonary disease (Qi deficiency and blood stasis syndrome]
PubMed ID: 25286684
Fu-Fang-Dan-Shen reduced endothelin and fewer COPD exacerbations — consistent with anti-inflammatory/vasomotor effects in respiratory disease (multi-agent).
- Tanshinone I and Tanshinone IIA/B attenuate LPS-induced mastitis via regulating the NF-κB
PubMed ID: 33578236
Tanshinones plus antibiotics associated with clinical improvement in mastitis and preclinical reductions in TNF‑α/IL‑1β/IL‑6 (strong anti‑inflammatory signal).
- Combination of Activating Blood Circulation and Detoxifying Chinese Medicines Played an Anti-Inflammatory Role in Unstable Angina Patients after Percutaneous Coronary Intervention: A Multicenter, Open-Labeled, Randomized Controlled Trial
PubMed ID: 34532749
Guanxin Danshen combination lowered hs‑CRP, IL‑6 and TNF‑α vs Danshen alone in unstable angina (multicenter RCT evidence for anti‑inflammatory effect).
- A randomized controlled study on an integrated approach to prevent and treat re-adhesion after transcervical resection of moderate-to-severe intrauterine adhesions
PubMed ID: 33978070
Intrauterine Danshen perfusion reduced re‑adhesion and improved recovery after TCRA, plausibly via local anti‑inflammatory/fibrosis‑modulating effects.
- Effect of Compound Danshen Injection Combined with Magnesium Sulfate on Oxidative Stress, TNF-α, NO, and Therapeutic Efficacy in Severe Preeclampsia
PubMed ID: 35898773
Compound Danshen added to magnesium sulfate decreased TNF‑α and improved clinical inflammatory/hemodynamic markers in severe preeclampsia.
- [Treatment of Chronic Endometritis by Penning Granule: a Clinical Randomized Controlled Trial]
PubMed ID: 30645842
Multi-herb granule including Danshen improved endometrial inflammatory markers (CD38, HIF-1α) versus antibiotics.
- Effects of Silybum marianum, Pueraria lobate, combined with Salvia miltiorrhiza tablets on non-alcoholic fatty liver disease in adults: A triple-blind, randomized, placebo-controlled clinical trial
PubMed ID: 38879879
Herbal tablet with salvianolic acid significantly lowered hs-CRP, demonstrating anti-inflammatory effect (combination product).
Vitality (6)
- Effects of Dan Shen (Salvia miltiorrhiza) on blood pressure management in hypertensive patients: a randomized controlled trial
PubMed ID: 40658027
Marked SF‑36 vitality domain improvement (+20.9) in a large RCT indicates meaningful increase in perceived vitality.
- Chinese Herbal Medicine Treatment Improves the Overall Survival Rate of Individuals with Hypertension among Type 2 Diabetes Patients and Modulates In Vitro Smooth Muscle Cell Contractility
PubMed ID: 26699542
Observational association with higher survival in CHM users (Danshen among top herbs) suggests possible contribution to overall vitality at population level.
- Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates chronic fatigue: a randomised, double-blind, controlled pilot study
PubMed ID: 19398067
Astragalus–Salvia combo reduced fatigue severity in chronic fatigue patients, consistent with improved vitality.
- Salvia miltiorrhiza adjuvant therapy facilitates cardiac function recovery in patients with myocardial infarction
PubMed ID: 40089929
Improved cardiac function/hemodynamics after MI would be expected to raise overall vitality and functional capacity.
- Immunomodulatory effects of yun zhi and danshen capsules in health subjects--a randomized, double-blind, placebo-controlled, crossover study
PubMed ID: 14996412
Double-blind RCT in healthy volunteers showed improvements in cellular immunity markers, consistent with increased vitality.
- [Effect of combined therapy of shenmai and compound danshen injection on myocardial reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction]
PubMed ID: 15250199
Improved cardiac recovery and earlier normalization of oxidative/inflammatory markers after PCI suggests improved overall recovery/vitality.
Cholesterol (8)
- Effects of Dan Shen (Salvia miltiorrhiza) on blood pressure management in hypertensive patients: a randomized controlled trial
PubMed ID: 40658027
Trial reported improvements in lipid and glucose profiles alongside BP reductions in hypertensive patients (supporting an effect on lipid balance).
- [Effection of compositie salviae dropping pill on hyperlipemia patients with phlegm and blood stasis syndrome]
PubMed ID: 17511155
Salvia-containing drop pill lowered total cholesterol comparably to simvastatin in a small trial (multi-ingredient product).
- [Clinical study on effect and therapeutical mechanism of composite Salvia injection on acute cerebral infarction]
PubMed ID: 12584834
Composite Salvia reduced ApoB100 and increased ApoA1 in acute ischemic stroke patients—supporting improved apolipoprotein/lipid profile.
- Effects of replenishing qi, promoting blood circulation and resolving phlegm on vascular endothelial function and blood coagulation system in senile patients with hyperlipemia
PubMed ID: 16817277
Danshen Jueming granules reduced total cholesterol and LDL‑C and improved coagulation/endothelial markers in hyperlipidemic elderly.
- The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients
PubMed ID: 19388864
Danshen+Pueraria produced a modest LDL decrease alongside endothelial improvements in coronary patients.
- [Effect of compound danshen dripping pill on arterial intima-media thickness in patients with newly diagnosed type 2 diabetes mellitus]
PubMed ID: 21302487
Compound Danshen improved HbA1c and lowered TC/LDL and slowed IMT progression in new T2DM—favourable lipid/ metabolic effects.
- A randomized placebo controlled trial of an innovative herbal formula in the prevention of atherosclerosis in postmenopausal women with borderline hypercholesterolemia
PubMed ID: 24906587
12-month RCT of Danshen+Gegen showed modest but significant LDL and total cholesterol reductions versus placebo — good evidence for lipid-lowering effect.
- Interaction of clopidogrel and fufang danshen dripping pills assay in coronary heart disease based on non-target metabolomics
PubMed ID: 30703494
Metabolomics indicated normalization of lipid-related metabolites when Danshen-containing product added to clopidogrel — indirect support for lipid metabolism effects.
Liver support (8)
- [Influence of Salvia miltiorrhizae and Astragalus membranaceus on hemodynamics and liver fibrosis indexes in liver cirrhotic patients with portal hypertension]
PubMed ID: 12577420
Salvia combined with Astragalus improved portal hypertension measures and reduced fibrosis markers in cirrhosis patients (combination therapy).
- [The effect of salvia miltiorrhiza and shengmai on inflammatory mediator and renal function of post-operative patients with obstructive jaundice]
PubMed ID: 12528557
Post-op reductions in inflammatory mediators and endothelin in obstructive jaundice patients suggest hepatic-protective effects.
- [Therapeutic effect of combined therapy of Salvia miltiorrhizae and Polyporus umbellatus polysaccharide in the treatment of chronic hepatitis B]
PubMed ID: 8111209
Combined Salvia + polysaccharide improved ALT normalization and HBeAg conversion rates in chronic hepatitis B.
- [Comparative study of the clinical effects of salvia miltiorrhiza injection and shengmai injection on chronic hepatitis B]
PubMed ID: 17121050
In chronic hepatitis B, SMI improved liver function and reduced fibrosis markers versus comparator.
- [Clinical study on treatment of cirrhosis by different dosages of salvia injection]
PubMed ID: 16447879
Randomized trial in HBV-related cirrhosis showed improved ALT/TBil and decreased fibrosis markers with Salvia injections (dose response).
- Effects of Silybum marianum, Pueraria lobate, combined with Salvia miltiorrhiza tablets on non-alcoholic fatty liver disease in adults: A triple-blind, randomized, placebo-controlled clinical trial
PubMed ID: 38879879
Silybin+puerarin+salvianolic acid tablet reduced hs-CRP and increased aldehyde-dehydrogenase activity with trend to lower liver fat (salvianolic acid is Danshen component).
- Clinical efficacy of Rong-Yang-Jyh-Gan-Tang on patients with chronic hepatitis C: A double-blinded randomized placebo-controlled crossover study
PubMed ID: 27965049
Multi-herb formula including Danshen increased the proportion of HCV patients with decreased viral RNA and symptom improvement (small trial).
- [Clinical study on treatment of liver fibrosis by different dosages of Salvia injection]
PubMed ID: 14976882
Different doses of Salvia injection (with decoction) lowered liver enzymes and fibrosis markers (dose-response reported).
Detoxification (6)
- [Effects of Salvia miltiorrhiza on oxidative stress and microinflammatory state in patients undergoing continuous hemodialysis]
PubMed ID: 17058827
Reduction in oxidative protein products in dialysis patients suggests supportive effects on removal/mitigation of toxic oxidative species.
- [Influence of Salvia miltiorrhizae and Astragalus membranaceus on hemodynamics and liver fibrosis indexes in liver cirrhotic patients with portal hypertension]
PubMed ID: 12577420
Improved portal flow and fibrosis marker reductions in cirrhosis imply improved hepatic clearance/function (Salvia + Astragalus).
- [Effect of Astragali and Angelica particle on proteinuria in Chinese patients with primary glomerulonephritis]
PubMed ID: 27468543
Large RCT of multi-herb pill (including Danshen) produced sustained reductions in proteinuria vs losartan, indicating renal 'detox'/clearance benefits (combination product).
- [Clinical study on treatment of cirrhosis by different dosages of salvia injection]
PubMed ID: 16447879
Improved liver function and reduced fibrosis markers support liver-mediated detox capacity.
- [The effect of salvia miltiorrhiza and shengmai on inflammatory mediator and renal function of post-operative patients with obstructive jaundice]
PubMed ID: 12528557
Post-op reductions in inflammatory and renal protein markers indicate enhanced clearance/protection consistent with detox support.
- [Application of Danshen injection on early stage of renal transplantation]
PubMed ID: 15957830
Improved urine volume and creatinine clearance after transplant indicate improved renal clearance/detoxification (adjunctive result).
Brain health (6)
- [Observation of therapeutic effect of Salviae miltiorrhiza and cytosine diphosphate-choline injection on patients with hypertensive cerebral hemorrhage]
PubMed ID: 11783323
In hypertensive cerebral hemorrhage, Salvia injection improved clinical outcomes and hematoma absorbability—robust neurologic benefit.
- [Clinical study on effect and therapeutical mechanism of composite Salvia injection on acute cerebral infarction]
PubMed ID: 12584834
Acute ischemic stroke patients had reduced oxidative stress and improved apolipoproteins with composite Salvia injection.
- [Clinical observation of compound salvia injection in treating mid-severe infantile hypoxic-ischemic encephalopathy]
PubMed ID: 12575591
Compound Salvia injection in neonatal HIE improved clinical recovery and decreased brain-injury markers.
- Effect of Salvia Miltiorrhiza Polyphenolic Acid Injection on Improving Limb Use and Cognitive Impairment in Patients with Acute Stroke
PubMed ID: 35983530
Adjunctive salvianolic acid injection associated with improved NIHSS, reduced infarct volume and better cognitive/functional scores in acute stroke patients (strong brain support signal).
- Clinical observation of Danhong Injection (herbal TCM product from Radix Salviae miltiorrhizae and Flos Carthami tinctorii) in the treatment of traumatic intracranial hematoma
PubMed ID: 19427180
Danhong adjunct to care sped hematoma absorption and improved neurological scores after intracerebral hemorrhage.
- Forty-six cases of acute cerebral infarction treated with the combined use of acupuncture and drugs
PubMed ID: 18246677
Acupuncture + Danshen injection improved clinical recovery and oxidative stress markers after acute cerebral infarction—direct neurological benefit.
Skin health (4)
- [Therapeutic effect of the combination of traditional Chinese medicine and western medicine on patients with oral submucous fibrosis]
PubMed ID: 20448359
Danshen + prednisolone improved oral submucous fibrosis lesion size and efficacy—benefit to mucosal/skin tissue health.
- [Evaluation of a compound with dan-shen root and azone for scar treatment]
PubMed ID: 15449627
Topical Dan-shen + azone dressing significantly improved hypertrophic scar cure rate and increased skin permeability—strong topical skin benefit.
- Randomized clinical trial of Chinese herbal medications to reduce wound complications after mastectomy for breast carcinoma
PubMed ID: 20862715
IV Salvia miltiorrhiza markedly reduced mastectomy skin‑flap ischemia/necrosis and improved wound scores—robust skin‑healing effect.
- Efficacy of salvianolic acid B combined with triamcinolone acetonide in the treatment of oral submucous fibrosis
PubMed ID: 23260769
Salvianolic acid B improved mouth opening and reduced burning in oral submucous fibrosis — benefit to mucosal (skin-like) tissue health.
Respiratory comfort (4)
- [Effects of "reinforcing Qi and activating blood" on stable chronic obstructive pulmonary disease (Qi deficiency and blood stasis syndrome]
PubMed ID: 25286684
Fu-Fang-Dan-Shen added to conventional COPD care reduced endothelin and lowered exacerbation frequency and hospitalizations — meaningful respiratory clinical benefit (multi-agent regimen).
- [Effect of depsides salts from salvia miltiorrhiza on functions of platelet and vascular endothelial cell of patients with chronic obstructive pulmonary disease in acute exacerbation stage]
PubMed ID: 20519076
Depside salts from Danshen lowered platelet and endothelial activation markers in severe COPD exacerbations—biochemical improvement in COPD context may translate to respiratory benefit.
- [Effects of injection Salviae miltiorrhizae on senile chronic asthmatic bronchitis patients]
PubMed ID: 9387732
Injection Salviae miltiorrhizae improved PaO2, PaCO2 and pulmonary function and clinical symptoms in chronic asthmatic bronchitis.
- [Effect of Salvia miltiorrhiza on lipid peroxidation antioxidant enzymes activity in patients with chronic cor pulmonale]
PubMed ID: 7841755
Chronic cor pulmonale study showed improved antioxidant enzymes and reduced LPO, with clinical benefit in pulmonary disease.
Energy & Fatigue (2)
- Effects of Dan Shen (Salvia miltiorrhiza) on blood pressure management in hypertensive patients: a randomized controlled trial
PubMed ID: 40658027
Significant increases in SF‑36 vitality are consistent with increased subjective energy levels.
- Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates chronic fatigue: a randomised, double-blind, controlled pilot study
PubMed ID: 19398067
Randomized double-blind pilot showed reduced fatigue severity with Astragalus+Salvia extract at lower dose.
Stress resilience (2)
- Immunomodulatory effects of yun zhi and danshen capsules in health subjects--a randomized, double-blind, placebo-controlled, crossover study
PubMed ID: 14996412
Immunomodulatory effects (increased CD4, IFN-γ) in healthy volunteers could support resilience to stressors.
- Guanxin Danshen Dripping Pills Improve Quality of Life and Cardiovascular Prognoses of CHD Patients after PCI with Anxiety or Depression (GLAD Study): A Randomized Double-Blind Placebo-Controlled Study
PubMed ID: 36301456
Significant reductions in anxiety (GAD‑7) and improved QoL suggest enhanced psychological resilience to stress in CHD patients.
Joint comfort (2)
- [Effect of point injection of red-sage-root on the hip joint function in ischemic femoral head necrosis patients]
PubMed ID: 19526810
Local Danshen injections improved pain, hip range-of-motion and daily-activity scores in ischemic femoral head necrosis (clinical improvement in joint function).
- Oral opening training increases oral opening in patients with oral submucous fibrosis
PubMed ID: 34382590
Local Salvia injection used in TMJ patients produced substantial, sustained increases in mouth opening (clinical benefit for jaw joint mobility).
Eye health (1)
- The effectiveness and safety of a danshen-containing Chinese herbal medicine for diabetic retinopathy: a randomized, double-blind, placebo-controlled multicenter clinical trial
PubMed ID: 25666427
Large double-blind RCT: Compound Danshen Dripping Pill produced substantial, dose-dependent improvements in FFA and fundoscopic findings in NPDR — strong direct ophthalmic benefit.
Mood balance (1)
- Guanxin Danshen Dripping Pills Improve Quality of Life and Cardiovascular Prognoses of CHD Patients after PCI with Anxiety or Depression (GLAD Study): A Randomized Double-Blind Placebo-Controlled Study
PubMed ID: 36301456
Guanxin Danshen Dripping Pills produced clinically meaningful reductions in PHQ‑9 and GAD‑7 vs placebo in CHD patients (robust RCT evidence).
Similar by evidence
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Products with Danshen
Search all47 products whose verified label declares Danshen — not every bottle that mentions it in a title.