Curcumin
18 benefits mapped to clinical evidence across supplements.
Dose per serving from products
279 products in our catalogue print how much Curcumin a serving holds.
Most common: 100 mg to 250 mg, 23% of 279 products.
| Dose per serving | Products |
|---|---|
| 10 mg or less | 12 |
| 10 mg to 25 mg | 17 |
| 25 mg to 50 mg | 63 |
| 50 mg to 100 mg | 48 |
| 100 mg to 250 mg | 65 |
| 250 mg to 500 mg | 45 |
| 500 mg to 1 g | 24 |
| over 1 g | 5 |
Dose per serving from research
289 study groups in 229 studies say how much Curcumin participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 24% of 289 study groups.
| Daily dose | Study groups |
|---|---|
| 50 mg or less | 9 |
| 50 mg to 100 mg | 39 |
| 100 mg to 250 mg | 68 |
| 250 mg to 500 mg | 69 |
| 500 mg to 1 g | 60 |
| 1 g to 2.5 g | 28 |
| 2.5 g to 5 g | 12 |
| over 5 g | 4 |
Commonly used together
67 of 287 study groups took Curcumin with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Piperine | 30 |
| Turmeric | 6 |
| Fish Oil | 5 |
| Boswellia | 3 |
| Docosahexaenoic Acid | 3 |
| Omega-3 Fatty Acids | 3 |
Benefit Evidence
Lipids/endothelial health
+37% FMD, -58 mg/dL TG
Glucose/BP/inflammation
IBS symptoms/bloating +40%
UC remission/markers +53%
Mucositis pain/grade -0.84
IBS symptoms/bloating +40%
UC remission/markers +53%
Mucositis pain/grade -0.84
Research sources
Inflammation (77)
- Herbal formulation "turmeric extract, black pepper, and ginger" versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial
PubMed ID: 32180294
Turmeric/black-pepper/ginger reduced synovial PGE2 in knee OA to a degree comparable with naproxen (meaningful anti-inflammatory action).
- Nano-curcumin supplementation in critically ill patients with sepsis: a randomized clinical trial investigating the inflammatory biomarkers, oxidative stress indices, endothelial function, clinical outcomes and nutritional status
PubMed ID: 35621073
Nanocurcumin produced broad reductions in pro-inflammatory cytokines and improved clinical sepsis markers (strong anti-inflammatory effect).
- Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized, placebo-controlled clinical trial
PubMed ID: 36799355
Curcumin+piperine decreased blood glucose, cholesterol and ALT (metabolic/inflammatory improvements in NAFLD).
- Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study
PubMed ID: 18588355
Curcumin reduced IL-6, TNFα and oxidative stress while improving endothelial function in type 2 diabetes (clear anti-inflammatory effects).
- A Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled Study
PubMed ID: 30345312
Curcumin reduced CRP and IL-6 in chronic alcohol users (supporting balanced inflammation).
- Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial
PubMed ID: 37378780
Curcumin–piperine reduced CRP in ICU COVID patients in a short trial (anti-inflammatory signal).
- Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study
PubMed ID: 29316908
Clinical OA study showed symptom improvement consistent with anti‑inflammatory effects (combination with Boswellia enhanced effect).
- Influence of a low-dose supplementation of curcumagalactomannoside complex (CurQfen) in knee osteoarthritis: A randomized, open-labeled, active-controlled clinical trial
PubMed ID: 33210408
Trial reported reductions in inflammatory markers alongside clinical OA improvements.
- Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study
PubMed ID: 32678677
Curcumagalactomannoside+glucosamine led to marked decreases in IL‑1β and IL‑6 (inflammatory markers).
- Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery
PubMed ID: 38901949
CABG patients had decreased CRP after curcumin+piperine — evidence of systemic anti‑inflammatory action in surgical context.
- The dose-response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise-induced muscle damage in males
PubMed ID: 40781899
Reduced oxidative stress and soreness at higher doses suggests inflammation‑modulating effects post‑exercise.
- Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial
PubMed ID: 17101300
Clinically reduced relapse and improved disease activity in ulcerative colitis is consistent with meaningful anti‑inflammatory/immune modulation.
- Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study
PubMed ID: 21627399
Two‑month turmeric lowered proteinuria and decreased TGF‑β and IL‑8 in diabetic kidney disease—clear anti‑inflammatory biomarker changes.
- A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications
PubMed ID: 23038702
Significant reductions in IL‑8 and hs‑CRP in chronic skin inflammation study indicate balanced inflammatory modulation.
- A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis
PubMed ID: 22407780
RA trial showed clinical improvement consistent with anti‑inflammatory actions.
- Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting
PubMed ID: 22481014
Perioperative reduction in CRP and oxidative biomarkers indicates strong anti‑inflammatory effects in surgical setting.
- Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial
PubMed ID: 24678280
RCT showed reductions in IL‑1β, IL‑4 and VEGF—direct evidence for anti‑inflammatory action.
- Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial
PubMed ID: 24648302
Broad reductions in TNF‑α, TGFβ, hs‑CRP and other markers in chemo patients.
- Short-term Curcuminoid Supplementation for Chronic Pulmonary Complications due to Sulfur Mustard Intoxication: Positive Results of a Randomized Double-blind Placebo-controlled Trial
PubMed ID: 25268878
Multiple inflammatory mediators were significantly reduced and lung function improved in sulfur‑mustard patients.
- Curcuminoids Target Decreasing Serum Adipocyte-fatty Acid Binding Protein Levels in Their Glucose-lowering Effect in Patients with Type 2 Diabetes
PubMed ID: 25374024
Significant decreases in CRP, TNF‑α and IL‑6 in T2D indicate anti‑inflammatory effects.
- Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis
PubMed ID: 25618800
CRP reductions and other marker improvements in metabolic syndrome strongly support inflammation balance.
- Chronic Supplementation of Curcumin Enhances the Efficacy of Antidepressants in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
PubMed ID: 26066335
Adjunctive curcumin lowered IL‑1β and TNF‑α alongside clinical depression improvements.
- Effects of curcumin on crevicular levels of IL-1β and CCL28 in experimental gingivitis
PubMed ID: 26219195
Topical curcumin produced significantly smaller increases in gingival IL‑1β and CCL28 compared with chlorhexidine in experimental gingivitis.
- Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial
PubMed ID: 27470399
RCT showed robust reductions in multiple systemic inflammatory cytokines in metabolic syndrome.
- Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis
PubMed ID: 27789120
Allergic rhinitis RCT showed suppression of IL‑4, IL‑8, TNF‑α and increased IL‑10—clear immunomodulation.
- Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus
PubMed ID: 29299989
Curcuminoids+piperine lowered TNF‑α and modified adipokines in T2D, indicating anti‑inflammatory effects.
- A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study
PubMed ID: 28850308
RA RCT showed decreases in CRP/ESR and improved clinical disease activity, demonstrating anti‑inflammatory benefit.
- The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients
PubMed ID: 28478481
Omega‑3 + nano‑curcumin lowered TNF‑α and reduced migraine attacks more than either alone — clear anti‑inflammatory and clinical signal (combination product).
- Curcumin improves treatment outcome of Takayasu arteritis patients by reducing TNF-α: a randomized placebo-controlled double-blind clinical trial
PubMed ID: 28349250
Curcumin reduced BVAS and inflammatory markers (TNF‑α, CRP, ESR) in Takayasu arteritis — strong evidence for anti‑inflammatory effect in an inflammatory vascular disease.
- A Novel Combination of ω-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study
PubMed ID: 29938621
Nano‑curcumin reduced IL‑6 expression and hs‑CRP in migraine patients, supporting anti‑inflammatory activity (direct biomarker changes).
- The Combined Effects of ω -3 Fatty Acids and Nano-Curcumin Supplementation on Intercellular Adhesion Molecule-1 (ICAM-1) Gene Expression and Serum Levels in Migraine Patients
PubMed ID: 29237386
Combined ω‑3 and nano‑curcumin reduced serum ICAM‑1 and migraine frequency (evidence of reduced endothelial/inflammatory activity; curcumin contribution plausible).
- Nanocurcumin improves regulatory T-cell frequency and function in patients with multiple sclerosis
PubMed ID: 30683426
MS trial increased regulatory T cells and anti‑inflammatory cytokines — evidence for shifting inflammatory balance.
- Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial
PubMed ID: 31345163
NAFLD trial showed within‑group reductions in TNF‑α and NF‑κB activity though not superior to lifestyle — supports anti‑inflammatory effect.
- The Neuromodulatory Effects of ω-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms
PubMed ID: 30760195
Reduced COX‑2 and iNOS expression in migraine, consistent with modulation of inflammatory pathways.
- Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo-controlled clinical trial
PubMed ID: 31206225
Significant reductions in IL‑6 and hs‑CRP and increased TAC in overweight adolescents — strong anti‑inflammatory signal.
- Oral administration of nanomicelle curcumin in the prevention of radiotherapy-induced mucositis in head and neck cancers
PubMed ID: 30761565
Large reduction in radiotherapy mucositis incidence/severity implies anti‑inflammatory/local protective action.
- Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study
PubMed ID: 31351488
Symptomatic improvements in OA accompanied by reduced cartilage degradation biomarker (anti‑inflammatory/cartilage protective effect).
- The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis
PubMed ID: 31802559
Curcumin decreased clinical colitis scores and systemic inflammatory markers (hs‑CRP, ESR) in UC (clear anti‑inflammatory effect).
- The Effects of Nano-curcumin on Metabolic Status in Patients With Diabetes on Hemodialysis, a Randomized, Double Blind, Placebo-controlled Trial
PubMed ID: 32655024
Significant hs‑CRP reduction and other inflammatory marker improvements in diabetic dialysis cohort.
- The effects of nano-curcumin supplementation on Th1/Th17 balance in migraine patients: A randomized controlled clinical trial
PubMed ID: 33147541
Clear reduction in IL‑17 expression and serum levels in migraine patients — anti‑inflammatory effect.
- Impact of curcumin supplementation on expression of inflammatory transcription factors in hemodialysis patients: A pilot randomized, double-blind, controlled study
PubMed ID: 32204978
Significant reductions in NF‑κB mRNA and hsCRP demonstrate an anti‑inflammatory effect in dialysis patients.
- The Effect of Nanocurcumin in Improvement of Knee Osteoarthritis: A Randomized Clinical Trial
PubMed ID: 31868149
Improvements in OA symptoms (pain/stiffness/function) likely mediated by anti‑inflammatory mechanisms.
- Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial
PubMed ID: 32147075
Reductions in TNF‑α, MCP‑1 and other cytokines with improvement in NAFLD indicate anti‑inflammatory action.
- Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients
PubMed ID: 33129099
Strong reductions in IL‑1β, IL‑6, TNF‑α and other cytokines in RCT of hospitalized COVID‑19 patients.
- Significant immunomodulatory properties of curcumin in patients with osteoarthritis; a successful clinical trial in Iran
PubMed ID: 32540725
OA trial showed CRP decrease and favorable shifts in T‑cell subsets (Treg/Th17 ratio) — inflammation balanced.
- Effects of curcuminoids on inflammatory and oxidative stress biomarkers and clinical outcomes in critically ill patients: A randomized double-blind placebo-controlled trial
PubMed ID: 34080237
Short ICU TBI trial showed decreases in IL‑6 and TNF‑α and improved illness severity scores.
- Curcumin Nanomicelle Improves Lipid Profile, Stress Oxidative Factors and Inflammatory Markers in Patients Undergoing Coronary Elective Angioplasty; A Randomized Clinical Trial
PubMed ID: 33397249
Reductions in TNF‑α and other inflammatory markers in post‑angioplasty patients indicate anti‑inflammatory effects.
- The omega-3 and Nano-curcumin effects on vascular cell adhesion molecule (VCAM) in episodic migraine patients: a randomized clinical trial
PubMed ID: 34301320
Nano‑curcumin (±omega‑3) reduced VCAM and related inflammatory gene expression in migraine patients.
- Effects of Curcuminoids on Systemic Inflammation and Quality of Life in Patients with Colorectal Cancer Undergoing Chemotherapy: A Randomized Controlled Trial
PubMed ID: 34981467
Curcuminoids lowered CRP and ESR in colorectal cancer patients — clear systemic anti‑inflammatory signal.
- Nanocurcumin supplementation ameliorates Behcet's disease by modulating regulatory T cells: A randomized, double-blind, placebo-controlled trial
PubMed ID: 34653732
In Behçet's, nanocurcumin increased regulatory/anti‑inflammatory markers (FoxP3, TGF‑β, IL‑10) and lowered disease activity.
- The effects of nanocurcumin supplementation on inflammation in hemodialysis patients: A randomized controlled trial
PubMed ID: 33559343
Nanocurcumin significantly lowered IL‑6 and TNF‑α serum levels and gene expression in hemodialysis patients (strong anti‑inflammatory evidence).
- A Randomized, Placebo-Controlled Study to Evaluate the Effect of Bio-Enhanced Turmeric Formulation on Radiation-Induced Oral Mucositis
PubMed ID: 34161952
Clinical reductions in mucositis, pain and dermatitis during chemoradiotherapy reflect anti‑inflammatory effects.
- Three months of combination therapy with nano-curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 35674733
Nano‑curcumin reduced hs‑CRP and Lp(a) in diabetics with CAD—strong anti‑inflammatory signal.
- Co-Administration of Iron and Bioavailable Curcumin Reduces Levels of Systemic Markers of Inflammation and Oxidative Stress in a Placebo-Controlled Randomised Study
PubMed ID: 35277071
Well‑powered RCT showed decreases in TNF and subgroup IL‑6 and prevented TBARS rise with iron coadministration.
- Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 35178811
RA patients experienced reduced ESR and hs‑CRP and other inflammatory improvements over 8 weeks.
- Antiinflammatory potential of nano-curcumin as an alternative therapeutic agent for the treatment of mild-to-moderate hospitalized COVID-19 patients in a placebo-controlled clinical trial
PubMed ID: 35040210
Nano‑curcumin reduced multiple proinflammatory cytokine mRNAs and serum IL‑1β in COVID patients.
- The effects of nano-curcumin supplementation on adipokines levels in obese and overweight patients with migraine: a double blind clinical trial study
PubMed ID: 35606882
Reduced MCP‑1 in migraine trial accompanied by clinical benefit—anti‑inflammatory mediation.
- Effect of curcumin on inflammatory biomarkers and iron profile in patients with premenstrual syndrome and dysmenorrhea: A randomized controlled trial
PubMed ID: 37394650
Curcumin modestly lowered hsCRP in young women with PMS/dysmenorrhea.
- Curcumin-QingDai Combination for Patients With Active Ulcerative Colitis: A Randomized, Double-Blinded, Placebo-Controlled Trial
PubMed ID: 37302449
Curcumin+QingDai produced large clinical and endoscopic improvements and calprotectin reductions in UC.
- The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial
PubMed ID: 38082237
Curcumin‑piperine lowered hsCRP and increased TAC in stroke rehabilitation patients.
- Curcumin Confers Anti-Inflammatory Effects in Adults Who Recovered from COVID-19 and Were Subsequently Vaccinated: A Randomized Controlled Trial
PubMed ID: 37049389
Bioavailable curcumin significantly lowered IL‑6 and MCP‑1 in a randomized placebo‑controlled pilot.
- Promising clinical outcomes of nano-curcumin treatment as an adjunct therapy in hospitalized COVID-19 patients: A randomized, double-blinded, placebo-controlled trial
PubMed ID: 37118944
COVID RCT showed reductions in CRP/ESR and multiple cytokines (IL‑6/IL‑8/IL‑10) — strong anti‑inflammatory signal.
- Efficacy of Nanocurcumin as an Add-On Treatment for Patients Hospitalized with COVID-19: A Double-Blind, Randomized Clinical Trial
PubMed ID: 37547100
Nanocurcumin reduced systemic inflammation markers and improved respiratory/clinical outcomes in COVID patients.
- Effect of phospholipid curcumin Meriva on liver histology and kidney disease in nonalcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial
PubMed ID: 38809154
Meriva NASH RCT produced histologic NASH resolution and fibrosis regression — major anti‑inflammatory/hepato‑protective effects.
- The effects of curcumin supplementation on inflammatory markers in systemic lupus erythematosus patients: a randomized placebo-controlled trial
PubMed ID: 39546036
SLE trial decreased IL‑6 and anti‑dsDNA titers, indicating dampening of autoimmune inflammatory activity.
- The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 38699839
RA RCT lowered disease activity scores alongside reductions in oxidative/inflammatory markers.
- The effectiveness of phytosomal curcumin on clinical and laboratory parameters of patients with multiple trauma admitted to the intensive care unit: a double-blind randomized placebo-controlled trial
PubMed ID: 39289667
Large CRP decrease in ICU patients over 7 days — clear anti‑inflammatory effect.
- The effect of curcumin and high-content eicosapentaenoic acid supplementations in type 2 diabetes mellitus patients: a double-blinded randomized clinical trial
PubMed ID: 38589346
Significant hs‑CRP reduction and antioxidant improvements in T2DM — strong anti‑inflammatory evidence.
- Nanocurcumin supplementation improves pulmonary function in severe COPD patients: A randomized, double blind, and placebo-controlled clinical trial
PubMed ID: 38178561
COPD RCT reduced IL‑6, an important systemic inflammatory mediator.
- Sustained Release of Liposomal Curcumin: Enhanced Periodontal Outcomes in Diabetic Patients
PubMed ID: 38953482
Periodontal study lowered TNF‑α and improved clinical inflammation metrics.
- Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
PubMed ID: 40573083
12‑month trial showed consistent TNF and other inflammatory marker reductions with hepatic benefit.
- Therapeutic effects of curcumin and piperine combination in critically ill patients with sepsis: a randomized double-blind controlled trial
PubMed ID: 40514680
Septic ICU RCT: marked CRP and ESR decreases over a short course.
- Curcumin supplementation improves the clinical outcomes of patients with diabetes and atherosclerotic cardiovascular risk
PubMed ID: 40759997
Diabetes + ASCVD risk RCT demonstrated declines in TNF‑α and inflammatory/oxidative markers.
- Nanomicelle curcumin improves oxidative stress, inflammatory markers, and assisted reproductive techniques outcomes in endometriosis cases: a randomized clinical trial
PubMed ID: 40088332
Endometriosis RCT reduced follicular IL‑8 and TNF‑α and lowered oxidative stress markers.
- Efficacy of curcumin supplementation for the treatment and prevention of pouchitis after ileal pouch-anal anastomosis: a randomized controlled trial
PubMed ID: 40295333
Curcumin reduced pouchitis recurrence and inflammatory markers—robust anti‑inflammatory clinical effect in intestinal disease.
- The effects of nanocurcumin on immune-related factors in the ankylosing spondylitis patients: a double-blind, randomized, placebo-controlled clinical trial
PubMed ID: 40106064
Nanocurcumin produced clear immunologic shifts (↑Treg, ↓Th17) in ankylosing spondylitis—strong evidence for anti‑inflammatory immune modulation.
- Evaluation of oral nano-curcumin formulation effectiveness in patients with mild to moderate ulcerative colitis: a randomized, placebo-controlled, double-blind clinical trial
PubMed ID: 40820062
Nano‑curcumin adjunct improved UC symptoms and endoscopic/histologic findings—evidence of mucosal anti‑inflammatory action.
Wellbeing (47)
- Adjunctive curcumin nano-micelles reduce overall pruritus intensity in refractory post-burn pruritus: A randomized controlled trial
PubMed ID: 41197197
Nano‑micelle curcumin reduced refractory post‑burn itch intensity (and trended toward better sleep/QoL)—benefit to patient comfort and wellbeing.
- The effect of curcumin on postpartum depression and anxiety in primiparous women: a double-blind randomized placebo-controlled clinical trial
PubMed ID: 40281561
Curcumin reduced postpartum depression and anxiety scores—clinically meaningful improvement in maternal wellbeing.
- Effect and Safety of Phytosomal Curcumin Supplementation on Migraine Patients: A Randomized, Double-Blind and Placebo-Controlled Trial
PubMed ID: 41136816
Phytosomal curcumin improved migraine outcomes, sleep, and QoL—meaningful overall wellbeing gains in people with migraine.
- Efficacy and Safety of Curcumin as an Adjuvant to Standard Chemotherapy in Advanced and Metastatic Breast Cancer Patients: A Randomized Controlled Study
PubMed ID: 40898993
Adjunct oral curcumin in metastatic breast cancer increased tumor response and improved tolerance and QoL—strong evidence for improved overall wellbeing in this context.
- Curcumin Supplementation Improves Gastrointestinal Symptoms in Women with Severe Obesity: A Double-Blind, Randomized, Placebo-Controlled Trial-A Pilot Study
PubMed ID: 40647170
GI symptom relief and some anthropometric change in obese women support improved wellbeing.
- Nanomicelle curcumin improves oxidative stress, inflammatory markers, and assisted reproductive techniques outcomes in endometriosis cases: a randomized clinical trial
PubMed ID: 40088332
Improved follicular oxidative/inflammatory milieu and ART outcomes suggest better reproductive wellbeing.
- The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial
PubMed ID: 40000988
Marked reduction in treatment‑related neuropathy in children likely improves quality of life and wellbeing.
- Effect of curcumin on fatigue and musculoskeletal health in postmenopausal women: a double-blind randomised controlled trial
PubMed ID: 40976665
Clinically meaningful improvements in fatigue and musculoskeletal health indicate increased wellbeing.
- Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
PubMed ID: 41096556
Large trial showed multi‑system metabolic and antioxidant benefits likely to improve overall health perception.
- Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
PubMed ID: 40573083
Sustained anti‑inflammatory and hepatic improvements in MASLD patients support general wellbeing.
- The effect of curcumin and high-content eicosapentaenoic acid supplementations in type 2 diabetes mellitus patients: a double-blinded randomized clinical trial
PubMed ID: 38589346
Multiple metabolic and inflammatory endpoints improved, likely benefiting overall health status.
- Curcumin Reduces Depression in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
PubMed ID: 39125295
Large year‑long RCT demonstrated substantial reductions in depression scores and biologic improvements — strong overall wellbeing signal.
- Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial
PubMed ID: 39354480
12‑month metabolic improvements (β‑cell, HOMA‑IR, HbA1c) in obese T2DM are likely to translate to better overall health/wellbeing.
- Effects of Highly Bioavailable Curcumin Supplementation on Common Cold Symptoms and Immune and Inflammatory Functions in Healthy Japanese Subjects: A Randomized Controlled Study
PubMed ID: 36927282
Fewer days with common cold symptoms in healthy adults supports day‑to‑day wellbeing.
- The effects of nano-curcumin supplementation on adipokines levels in obese and overweight patients with migraine: a double blind clinical trial study
PubMed ID: 35606882
Marked reductions in migraine frequency/duration translate into meaningful quality‑of‑life gains.
- Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 35178811
Multiple concordant improvements (inflammation, insulin resistance, anthropometrics) likely enhance wellbeing.
- Effects of Curcuminoids on Systemic Inflammation and Quality of Life in Patients with Colorectal Cancer Undergoing Chemotherapy: A Randomized Controlled Trial
PubMed ID: 34981467
Stage‑3 colorectal cancer RCT showed improved global/functional QoL scales alongside CRP/ESR reductions.
- Curcuma longa Linn versus omeprazole in treatment of functional dyspepsia: A randomized, double-blind, placebo-controlled trial
PubMed ID: 34652861
Dyspepsia RCT produced QoL improvements (EQ‑5D index) along with symptom relief.
- An Investigation into the Effects of a Curcumin Extract (Curcugen(®)) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study
PubMed ID: 35010916
Knee OA trial improved pain and objective function, which likely improves overall wellbeing.
- Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study
PubMed ID: 33478482
GI symptom improvement and large anxiety reduction support overall wellbeing gains.
- Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients
PubMed ID: 33129099
Symptom improvement and lower mortality signal clinical wellbeing benefits in COVID patients.
- An Exploratory Analysis of Changes in Mental Wellbeing Following Curcumin and Fish Oil Supplementation in Middle-Aged and Older Adults
PubMed ID: 32977404
Improved vigour and reduced subjective memory complaints indicate enhanced perceived wellbeing.
- The Effect of Nanocurcumin in Improvement of Knee Osteoarthritis: A Randomized Clinical Trial
PubMed ID: 31868149
OA symptom and function improvements translate into better quality of life/overall wellbeing.
- Curcumin ameliorates health-related quality of life in patients with liver cirrhosis: A randomized, double-blind placebo-controlled trial
PubMed ID: 32147077
Curcumin improved multiple QoL instruments in patients with cirrhosis (direct overall wellbeing improvements).
- Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study
PubMed ID: 32512782
Reduced fatigue and improved cognitive measures in older adults imply improved overall wellbeing.
- Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study
PubMed ID: 31351488
Reductions in knee pain and patient global assessment in OA patients indicate better daily wellbeing.
- The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: A triple blind randomised controlled trial
PubMed ID: 31987231
Clear reduction in hot‑flash frequency in postmenopausal women — clinically meaningful symptom relief improving wellbeing.
- Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study
PubMed ID: 30975196
Pain relief with fewer GI adverse effects and small weight loss — multiple factors that can improve overall wellbeing in OA patients.
- Safety and Efficacy of Nanocurcumin as Add-On Therapy to Riluzole in Patients With Amyotrophic Lateral Sclerosis: A Pilot Randomized Clinical Trial
PubMed ID: 29352425
Nanocurcumin add‑on in ALS was associated with fewer deaths/ventilation events (composite survival signal) which may reflect improved overall clinical outcomes/wellbeing in this small trial.
- Add-on Treatment with Curcumin Has Antidepressive Effects in Thai Patients with Major Depression: Results of a Randomized Double-Blind Placebo-Controlled Study
PubMed ID: 29327213
Adjunctive curcumin produced clinically meaningful reductions in depression scores over time and was well tolerated — directly impacts overall wellbeing.
- The efficacy of curcuminoids in improvement of ulcerative colitis symptoms and patients' self-reported well-being: A randomized double-blind controlled trial
PubMed ID: 30132960
Nanocurcumin as add‑on improved patient‑reported well‑being in mild–moderate UC (direct clinical wellbeing signal).
- Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome
PubMed ID: 27308645
Curcumin+fennel improved IBS symptoms and multiple QoL domains over 30 days (randomized trial).
- Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
PubMed ID: 27043120
Pilot RCT in stressed workers showed reduced stress/anxiety/fatigue and improved antioxidant markers, supporting overall wellbeing.
- Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study
PubMed ID: 26592847
Weight and body composition improvements likely contribute to overall wellbeing.
- Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis in a Randomized Controlled Trial
PubMed ID: 25724700
High remission rates and clinical responses in UC patients imply large wellbeing gains.
- Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population
PubMed ID: 25277322
Mood and cognitive improvements in older adults indicate improved subjective wellbeing.
- Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study
PubMed ID: 25046624
Modest antidepressant/mood improvements across weeks support wellbeing.
- Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial
PubMed ID: 24648302
QoL improvements in cancer patients on chemotherapy accompanied by reduced inflammatory markers.
- Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial
PubMed ID: 25171552
Respiratory QOL improved in sulfur‑mustard patients alongside antioxidant effects.
- Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study
PubMed ID: 24672232
OA symptom relief comparable to ibuprofen with fewer GI effects implies improved day‑to‑day wellbeing for patients.
- Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial
PubMed ID: 23832433
Depression trial showing comparable effects to fluoxetine supports mental/overall wellbeing improvement in small study.
- Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting
PubMed ID: 22481014
Reduction in perioperative MI and lower postoperative biomarkers are clinically meaningful overall wellbeing gains.
- Curcumin extract for prevention of type 2 diabetes
PubMed ID: 22773702
Prevention of diabetes and multi‑parameter metabolic improvements imply meaningful overall health benefits.
- A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications
PubMed ID: 23038702
Improved inflammatory markers and QoL measures in chronic skin lesions support better overall wellbeing.
- Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study
PubMed ID: 21671126
Postoperative reductions in pain and fatigue and large drop in analgesic use indicate substantial symptomatic wellbeing improvement.
- Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial
PubMed ID: 17101300
Curcumin reduced relapse and improved clinical/endoscopic scores in ulcerative colitis, likely improving patients' overall wellbeing when used adjunctively.
- Evaluation of oral nano-curcumin formulation effectiveness in patients with mild to moderate ulcerative colitis: a randomized, placebo-controlled, double-blind clinical trial
PubMed ID: 40820062
Adjunct nano‑curcumin improved UC clinical and endoscopic outcomes—translates into better patient wellbeing.
Immune support (51)
- Clearance of cervical human papillomavirus infection by topical application of curcumin and curcumin containing polyherbal cream: a phase II randomized controlled study
PubMed ID: 24289574
Topical polyherbal cream containing curcumin increased cervical HPV clearance vs placebo (local immune/antiviral effect).
- The Effect of Curcumin on Serum Copper and Zinc and Zn/Cu Ratio in Individuals with Metabolic Syndrome: A Double-Blind Clinical Trial
PubMed ID: 30020812
Curcumin increased serum zinc and Zn/Cu ratio (zinc supports immune function).
- Beneficial effects of the bioflavonoids curcumin and quercetin on early function in cadaveric renal transplantation: a randomized placebo controlled trial
PubMed ID: 16371925
Curcumin+quercetin combination improved early kidney graft function and reduced rejection rates — indicates immune-related effects though combined product confounds attribution.
- Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial
PubMed ID: 17101300
Reduced relapse and improved clinical/endoscopic scores in ulcerative colitis suggests immunomodulatory benefit as adjunct therapy.
- Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study
PubMed ID: 21627399
Turmeric lowered proteinuria and inflammatory/fibrosis markers (TGF‑β, IL‑8) in diabetic kidney disease—immune/inflammatory modulation.
- Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis - a randomized, placebo-controlled, pilot study
PubMed ID: 24011514
NCB‑02 enema showed improved clinical/endoscopic UC outcomes per‑protocol, consistent with mucosal immune modulation.
- Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial
PubMed ID: 24678280
Reduced pro/Th2 cytokines (IL‑1β, IL‑4) in obese adults suggests immunomodulatory effects.
- Nanomicelle curcumin improves oxidative stress, inflammatory markers, and assisted reproductive techniques outcomes in endometriosis cases: a randomized clinical trial
PubMed ID: 40088332
Endometriosis RCT: reduced follicular‑fluid pro‑inflammatory cytokines (IL‑8, TNF‑α).
- Curcumin plus piperine improve body composition in patients with inflammatory bowel disease: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 39934549
IBD trial: improved body composition with concurrent anti‑inflammatory context — supportive of immune benefit.
- Therapeutic effects of curcumin and piperine combination in critically ill patients with sepsis: a randomized double-blind controlled trial
PubMed ID: 40514680
Septic ICU RCT: notable CRP and ESR decreases over 7 days consistent with immune/inflammatory effects.
- Sustained Release of Liposomal Curcumin: Enhanced Periodontal Outcomes in Diabetic Patients
PubMed ID: 38953482
Periodontitis RCT: decreased TNF‑α and clinical improvement — local anti‑inflammatory/immune effect.
- Efficacy of highly bioavailable oral curcumin in asymptomatic or mild COVID-19 patients: a double-blind, randomized, placebo-controlled trial
PubMed ID: 38915116
COVID RCT: trends to less progression and lower fever — suggestive anti‑inflammatory/immune effects.
- Nanocurcumin supplementation improves pulmonary function in severe COPD patients: A randomized, double blind, and placebo-controlled clinical trial
PubMed ID: 38178561
COPD trial: IL‑6 decrease indicates systemic anti‑inflammatory/immune modulation.
- The Immunomodulatory Effects of Curcumin on Forkhead Box O1 and MicroRNA-873 in Patients with Osteoarthritis
PubMed ID: 39586746
Knee OA: upregulation of immune‑related genes/miRNA suggests immunomodulatory effects (molecular evidence).
- The effect of curcumin and high-content eicosapentaenoic acid supplementations in type 2 diabetes mellitus patients: a double-blinded randomized clinical trial
PubMed ID: 38589346
T2DM trial: hs‑CRP reduction and antioxidant marker improvements indicate anti‑inflammatory/immune benefit.
- The effectiveness of phytosomal curcumin on clinical and laboratory parameters of patients with multiple trauma admitted to the intensive care unit: a double-blind randomized placebo-controlled trial
PubMed ID: 39289667
ICU trauma RCT: large CRP reduction and platelet increases consistent with immunomodulation.
- Randomised Clinical Trial Study: The Combination of Vitamin D and Curcumin Piperine Attenuates Disease Activity and Pro-inflammatory Cytokines Levels Insystemic Lupus Erythematosus Patients
PubMed ID: 38299416
Combination curcumin‑piperine + vitamin D produced larger improvements in SLE activity and cytokines versus either alone — additive immune benefit.
- The effects of curcumin supplementation on inflammatory markers in systemic lupus erythematosus patients: a randomized placebo-controlled trial
PubMed ID: 39546036
SLE trial showed reductions in anti‑dsDNA and IL‑6, indicating modulation of autoimmune/inflammatory immune activity.
- Efficacy of Nanocurcumin as an Add-On Treatment for Patients Hospitalized with COVID-19: A Double-Blind, Randomized Clinical Trial
PubMed ID: 37547100
Nanocurcumin as add-on in COVID improved symptoms and oxygenation with reductions in inflammatory markers — clinically meaningful immune-related effects.
- Effects of Highly Bioavailable Curcumin Supplementation on Common Cold Symptoms and Immune and Inflammatory Functions in Healthy Japanese Subjects: A Randomized Controlled Study
PubMed ID: 36927282
Reduced cumulative days with common cold symptoms in a randomized trial — direct clinical immune/illness benefit.
- Promising clinical outcomes of nano-curcumin treatment as an adjunct therapy in hospitalized COVID-19 patients: A randomized, double-blinded, placebo-controlled trial
PubMed ID: 37118944
Nano-curcumin in hospitalized COVID-19 reduced inflammatory cytokines (IL‑6/IL‑8/IL‑10), CRP/ESR and improved clinical oxygen outcomes — immune-modulatory evidence.
- Curcumin Confers Anti-Inflammatory Effects in Adults Who Recovered from COVID-19 and Were Subsequently Vaccinated: A Randomized Controlled Trial
PubMed ID: 37049389
Bioavailable curcumin lowered pro‑inflammatory cytokines IL‑6 and MCP‑1 after COVID recovery.
- Curcumin-QingDai Combination for Patients With Active Ulcerative Colitis: A Randomized, Double-Blinded, Placebo-Controlled Trial
PubMed ID: 37302449
Curcumin+QingDai produced large clinical and endoscopic remission rates in ulcerative colitis.
- Effect of nanocurcumin supplementation on the severity of symptoms and length of hospital stay in patients with COVID-19: A randomized double-blind placebo-controlled trial
PubMed ID: 35023260
Nanocurcumin reduced symptom scores and improved O2 saturation in COVID inpatients.
- Antiinflammatory potential of nano-curcumin as an alternative therapeutic agent for the treatment of mild-to-moderate hospitalized COVID-19 patients in a placebo-controlled clinical trial
PubMed ID: 35040210
Nano‑curcumin in hospitalized COVID-19 reduced multiple proinflammatory cytokine mRNAs and serum IL‑1β.
- Co-Administration of Iron and Bioavailable Curcumin Reduces Levels of Systemic Markers of Inflammation and Oxidative Stress in a Placebo-Controlled Randomised Study
PubMed ID: 35277071
Large RCT showed curcumin with oral iron reduced proinflammatory markers (TNF, IL‑6 in subgroups).
- The effects of nanocurcumin supplementation on inflammation in hemodialysis patients: A randomized controlled trial
PubMed ID: 33559343
Nanocurcumin lowered serum IL‑6 and TNF‑α and their gene expression in hemodialysis patients (clear immunomodulatory effect).
- Nanocurcumin supplementation ameliorates Behcet's disease by modulating regulatory T cells: A randomized, double-blind, placebo-controlled trial
PubMed ID: 34653732
Nanocurcumin increased Treg frequency, FoxP3 and anti‑inflammatory cytokines and reduced disease activity in Behçet's disease.
- A triple-blind, placebo-controlled, randomized clinical trial to evaluate the effect of curcumin-containing nanomicelles on cellular immune responses subtypes and clinical outcome in COVID-19 patients
PubMed ID: 34541720
Nano‑curcumin altered immune‑related gene expression early in COVID‑19 patients (TBX21/FOXP3 changes).
- The effects of nano-curcumin supplementation on Th2/tregulatory axis in migraine patients: a randomized, double-blind, placebo-controlled trial
PubMed ID: 33657959
Nano‑curcumin increased anti‑inflammatory IL‑4 gene expression in migraine patients (immune modulation).
- Significant immunomodulatory properties of curcumin in patients with osteoarthritis; a successful clinical trial in Iran
PubMed ID: 32540725
Oral curcumin in OA reduced CRP and shifted T‑cell balance toward Treg phenotype — immune modulation.
- Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients
PubMed ID: 33129099
Nano‑curcumin significantly reduced IL-1β, IL-6, TNF-α and improved clinical outcomes in COVID‑19 — strong immunomodulation.
- Highly Bioavailable Curcumin Derivative Ameliorates Crohn's Disease Symptoms: A Randomized, Double-Blind, Multicenter Study
PubMed ID: 32412598
Theracurmin improved Crohn's disease clinical/endoscopic outcomes — likely mediated by immune effects.
- The effects of nano-curcumin supplementation on Th1/Th17 balance in migraine patients: A randomized controlled clinical trial
PubMed ID: 33147541
Nano‑curcumin lowered IL‑17 expression and serum levels in migraine patients — clear immune effect.
- The Effects of Nano-curcumin on Metabolic Status in Patients With Diabetes on Hemodialysis, a Randomized, Double Blind, Placebo-controlled Trial
PubMed ID: 32655024
Nano‑curcumin reduced hs‑CRP and other inflammatory markers in diabetic dialysis patients — immunomodulatory signal.
- Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo-controlled clinical trial
PubMed ID: 31206225
Reduced IL‑6 and hs‑CRP in overweight adolescents — supports systemic immune/inflammatory modulation.
- Nanocurcumin improves regulatory T-cell frequency and function in patients with multiple sclerosis
PubMed ID: 30683426
Nanocurcumin in MS robustly increased Treg frequency and anti‑inflammatory cytokines (strong immune modulation).
- Nanocurcumin restores aberrant miRNA expression profile in multiple sclerosis, randomized, double-blind, placebo-controlled trial
PubMed ID: 29194612
Nanocurcumin normalized multiple dysregulated immune miRNAs in RRMS patients over 6 months (direct biomarker evidence of immune modulation).
- Curcumin improves treatment outcome of Takayasu arteritis patients by reducing TNF-α: a randomized placebo-controlled double-blind clinical trial
PubMed ID: 28349250
In Takayasu arteritis curcumin reduced disease activity and lowered TNF‑α/CRP/ESR, indicating immunomodulatory effects in an immune‑mediated vasculitis.
- Clinical Comparison of Two Photosensitizers for Oral Cavity Decontamination
PubMed ID: 27828768
Curcumin used in photodynamic therapy reduced oral microbial counts immediately and at 24 h versus comparator.
- Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis
PubMed ID: 27789120
Large RCT in allergic rhinitis showed symptomatic improvement with suppression of pro‑inflammatory cytokines and increases in IL‑10/sICAM.
- Effects of curcumin on crevicular levels of IL-1β and CCL28 in experimental gingivitis
PubMed ID: 26219195
Topical curcumin produced substantially smaller increases in gingival IL‑1β and CCL28 vs chlorhexidine, indicating local immunomodulation.
- Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as a local drug delivery: a clinical and microbiological study
PubMed ID: 25961616
Topical curcumin reduced pocket depth/attachment loss and microbial counts in periodontitis, consistent with local antimicrobial/immunomodulatory effects.
- Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis
PubMed ID: 25618800
CRP reductions and other inflammatory marker changes in metabolic syndrome imply immune/inflammatory modulation.
- Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis in a Randomized Controlled Trial
PubMed ID: 25724700
Clinical and endoscopic remission in UC implies immune/inflammatory regulation in the gut.
- Curcuminoids Target Decreasing Serum Adipocyte-fatty Acid Binding Protein Levels in Their Glucose-lowering Effect in Patients with Type 2 Diabetes
PubMed ID: 25374024
Decreases in CRP, TNF‑α and IL‑6 in T2D show reduced systemic inflammation relevant to immune balance.
- Short-term Curcuminoid Supplementation for Chronic Pulmonary Complications due to Sulfur Mustard Intoxication: Positive Results of a Randomized Double-blind Placebo-controlled Trial
PubMed ID: 25268878
Broad suppression of inflammatory mediators in lung‑injury patients indicates immune‑modulating activity.
- Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial
PubMed ID: 24648302
Multiple systemic inflammatory marker reductions in cancer patients on chemotherapy support immune modulation.
- The effects of nanocurcumin on immune-related factors in the ankylosing spondylitis patients: a double-blind, randomized, placebo-controlled clinical trial
PubMed ID: 40106064
Nanocurcumin increased regulatory T cells and lowered Th17 cells in ankylosing spondylitis—clear immunomodulatory effects.
- The Combined Effects of an Anti-Inflammatory Diet and Curcumin Supplementation on Thyroid Function and Lipid Profile in Patients With Hashimoto's Thyroiditis: A Double Blind Randomised Clinical Trial
PubMed ID: 41329567
In Hashimoto's patients curcumin reduced anti‑TPO antibodies—direct evidence of modulation of autoantibody‑mediated immunity.
- Nano-curcumin supplementation in critically ill patients with sepsis: a randomized clinical trial investigating the inflammatory biomarkers, oxidative stress indices, endothelial function, clinical outcomes and nutritional status
PubMed ID: 35621073
Nanocurcumin reduced multiple inflammatory cytokines and improved clinical endpoints in septic ICU patients (strong immunomodulatory signal).
Heart health (39)
- The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
PubMed ID: 39125322
Large 12‑month RCT showed reductions in arterial stiffness (PWV) and improved lipid subfractions — direct heart/vascular risk improvements.
- Effect of nano-curcumin supplementation on cardiometabolic risk factors, physical and psychological quality of life, and depression in patients with coronary slow flow phenomenon: a randomized double-blind clinical trial
PubMed ID: 39085864
In coronary slow flow, nano‑curcumin improved QoL and prevented glycemic deterioration; modest cardiac-clinical relevance.
- The effect of curcumin-piperine supplementation on lipid profile, glycemic index, inflammation, and blood pressure in patients with type 2 diabetes mellitus and hypertriglyceridemia
PubMed ID: 39165011
Curcumin+piperine lowered triglycerides and fasting glucose in T2DM with hypertriglyceridemia — cardiometabolic benefit relevant to cardiac risk.
- The effect of curcumin and high-content eicosapentaenoic acid supplementations in type 2 diabetes mellitus patients: a double-blinded randomized clinical trial
PubMed ID: 38589346
Triglyceride and inflammation reductions in T2DM are favorable for cardiac risk.
- "The protective effect of nano curcumin supplementation on doxorubicin induced cardiotoxicity in breast cancer patients; a randomized, double-blind clinical trial"
PubMed ID: 39223927
Nanocurcumin preserved LVEF and prevented adverse LV remodeling during anthracycline chemotherapy — strong cardioprotective evidence.
- Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
PubMed ID: 41096556
Improved metabolic and hepatic markers in obese T2DM support downstream cardiovascular benefit.
- Curcumin supplementation improves the clinical outcomes of patients with diabetes and atherosclerotic cardiovascular risk
PubMed ID: 40759997
Significant SBP/DBP reductions and LDL/HDL improvements in diabetics with ASCVD risk.
- Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial
PubMed ID: 28158893
Metabolic improvements (BMI, waist, liver fat) have favorable implications for heart health.
- Effect of Phytosomal Curcumin on Circulating Levels of Adiponectin and Leptin in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 31204416
Increased HDL and adiponectin in NAFLD are cardioprotective changes.
- Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial
PubMed ID: 33861440
Nano-curcumin added to metformin lowered LDL-C substantially in women with PCOS (improvement in lipid risk factor).
- Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study
PubMed ID: 18588355
Curcumin improved endothelial function and lowered oxidative/inflammatory markers in type 2 diabetes (cardiovascular-relevant).
- Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress
PubMed ID: 28070018
Bioavailable curcumin markedly improved conduit and resistance artery endothelial function (physiological benefit to heart/vasculature).
- Curcumin and vitamin E improve hot flashes, lipid profile, and fasting blood glucose without any detrimental effect on the liver and renal function in postmenopausal women: A triple-blind placebo-controlled clinical trial
PubMed ID: 36053717
Curcumin improved fasting glucose and lipid profile in postmenopausal women, relevant to cardiovascular risk.
- A combined effect of Cavacurcumin, Eicosapentaenoic acid (Omega-3s), Astaxanthin and Gamma -linoleic acid (Omega-6) (CEAG) in healthy volunteers- a randomized, double-blind, placebo-controlled study
PubMed ID: 31987113
Multi-ingredient containing curcumin modestly lowered systolic blood pressure in healthy adults (BP benefit).
- Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial
PubMed ID: 30796508
Phytosomal curcumin reduced fasting glucose, HOMA-IR and triglycerides — metabolic changes supportive of cardiovascular risk reduction.
- Effect of adding fenofibrate versus curcumin to glimepiride in patients with type 2 diabetes: a randomized controlled trial
PubMed ID: 40481568
Curcumin improved glycemia and lipids and lowered hs‑CRP in T2DM, which are favorable for heart health.
- Effects of curcumin and/or coenzyme Q10 supplementation on metabolic control in subjects with metabolic syndrome: a randomized clinical trial
PubMed ID: 36192751
Curcumin improved triglycerides, raised HDL and lowered total cholesterol in metabolic‑syndrome subjects — changes supportive of cardiovascular health.
- Curcumin extract for prevention of type 2 diabetes
PubMed ID: 22773702
Prevention of diabetes and improved glycemic markers supports cardiovascular risk reduction.
- Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting
PubMed ID: 22481014
Perioperative curcuminoids around CABG significantly lowered in‑hospital MI incidence and reduced cardiac/oxidative biomarkers.
- Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial
PubMed ID: 25440375
Large RCT in metabolic syndrome: significant improvements in LDL, HDL, triglycerides and total cholesterol—strong cardiac risk benefit.
- Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial
PubMed ID: 25131839
12‑week curcumin reduced LDL and TG and increased HDL—clinically relevant for heart health.
- Curcuminoids Target Decreasing Serum Adipocyte-fatty Acid Binding Protein Levels in Their Glucose-lowering Effect in Patients with Type 2 Diabetes
PubMed ID: 25374024
Anti‑inflammatory and antioxidant changes in T2D can reduce cardiovascular risk.
- Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population
PubMed ID: 25277322
Lowered total and LDL cholesterol in older adults supports cardiovascular benefit.
- Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study
PubMed ID: 26592847
Body composition and waist reductions in overweight subjects can favor heart health.
- Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial
PubMed ID: 27124606
Lipid reductions in NAFLD (LDL, TG) are favorable for cardiovascular risk.
- Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial
PubMed ID: 27470399
Lowered systemic inflammatory cytokines in metabolic syndrome, which are risk factors for cardiovascular disease.
- Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD
PubMed ID: 27616885
Reduction of oxidized‑LDL surrogate (AT‑LDL) suggests potential cardiovascular benefit in a small RCT.
- Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial
PubMed ID: 28735818
Curcuminoids+piperine reduced total cholesterol, non‑HDL‑C and Lp(a) in T2D — clinically relevant atherogenic lipid improvements.
- Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial
PubMed ID: 29291429
Combination with phytosterols produced substantially larger reductions in total and LDL cholesterol — directly relevant to heart/atherosclerotic risk reduction.
- Effects on oral fat load of a nutraceutical combination of fermented red rice, sterol esters and stanols, curcumin, and olive polyphenols: A randomized, placebo controlled trial
PubMed ID: 29655700
Multi‑ingredient nutraceutical including curcumin improved lipids and endothelial markers (favorable for heart health but attribution to curcumin alone is limited).
- Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus
PubMed ID: 31871950
Theracurmin produced favorable changes in oxidized LDL and some lipids—markers relevant to cardiac risk.
- The Effects of Nano-curcumin on Metabolic Status in Patients With Diabetes on Hemodialysis, a Randomized, Double Blind, Placebo-controlled Trial
PubMed ID: 32655024
Reductions in total cholesterol, LDL and triglycerides indicate improved cardiovascular risk markers.
- Curcumin Nanomicelle Improves Lipid Profile, Stress Oxidative Factors and Inflammatory Markers in Patients Undergoing Coronary Elective Angioplasty; A Randomized Clinical Trial
PubMed ID: 33397249
Post‑angioplasty trial showed favorable lipid, antioxidant, and inflammatory marker changes—strong relevance to heart wellness.
- The Effects of Curcumin Plus Piperine Supplementation in Patients with Acute Myocardial Infarction: A Randomized, Double-Blind, and Placebo-Controlled Trial
PubMed ID: 34981479
Modest improvements in HbA1c and lipid profile in AMI patients (short‑term but relevant to cardiac risk).
- The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 33861432
Improvements in PWV and weight in metabolic syndrome imply cardiovascular benefit.
- The effects of nano-curcumin supplementation on glycemic control, blood pressure, lipid profile, and insulin resistance in patients with the metabolic syndrome: A randomized, double-blind clinical trial
PubMed ID: 33851448
Significant triglyceride lowering in metabolic syndrome supports heart risk reduction.
- Three months of combination therapy with nano-curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 35674733
In diabetics with CAD, nano‑curcumin significantly lowered hs‑CRP and Lp(a), markers linked to cardiovascular risk.
- Curcumin supplementation reduces blood glucose and serum lipids of Brazilian women with high waist circumference: a randomized clinical trial
PubMed ID: 36155119
90‑day curcumin lowered fasting glucose, triglycerides and total cholesterol—favorable cardiometabolic effects.
- The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial
PubMed ID: 38082237
Curcumin‑piperine reduced CIMT, triglycerides and blood pressure—markers relevant to cardiovascular health.
Antioxidant (41)
- Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD
PubMed ID: 27616885
Theracurmin decreased AT‑LDL (oxidized‑LDL marker) in mild COPD, indicating antioxidant/anti‑oxidative effects.
- Benefits of Curcumin Supplementation on Antioxidant Status in β-Thalassemia Major Patients: A Double-Blind Randomized Controlled Clinical Trial
PubMed ID: 28881347
Curcumin improved markers of oxidative stress and total antioxidant capacity in β‑thalassemia major in an RCT.
- Curcumin nanomicelle improves semen parameters, oxidative stress, inflammatory biomarkers, and reproductive hormones in infertile men: A randomized clinical trial
PubMed ID: 29193350
Curcumin nanomicelles increased total antioxidant capacity and reduced malondialdehyde in infertile men (RCT).
- Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo-controlled clinical trial
PubMed ID: 31206225
In adolescents curcumin increased total antioxidant capacity and reduced oxidative markers (MDA) — clear antioxidant signal.
- Efficacy of phytosomal curcumin among patients with non-alcoholic fatty liver disease
PubMed ID: 31818232
Phytosomal curcumin reduced markers of advanced glycation and DNA oxidation in NAFLD patients (direct antioxidant effects).
- Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus
PubMed ID: 31871950
Theracurmin prevented oxidized‑LDL rise (an oxidative stress endpoint) in IGT/mild diabetes.
- Curcumin administration and the effects on psychological status and markers of inflammation and oxidative damage in patients with type 2 diabetes and coronary heart disease
PubMed ID: 33183576
Curcumin improved MDA and TAC in patients with diabetes and heart disease (clear antioxidant marker changes).
- The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor γ coactivator 1α gene expression in polycystic ovarian syndrome (PCOS) patients: A randomized placebo-controlled clinical trial
PubMed ID: 31991296
Curcumin raised mitochondrial regulatory gene expression and glutathione peroxidase activity in PCOS patients.
- The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial
PubMed ID: 33200488
Nanocurcumin raised TAC and GSH and improved oxidative markers in diabetic patients (strong antioxidant signal).
- The Effects of Nano-curcumin on Metabolic Status in Patients With Diabetes on Hemodialysis, a Randomized, Double Blind, Placebo-controlled Trial
PubMed ID: 32655024
Nano‑curcumin increased TAC and lowered MDA in diabetic dialysis patients — clear antioxidant marker changes.
- Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial
PubMed ID: 32147075
Curcuminoid supplementation reduced inflammatory cytokines in NAFLD and likely reduced oxidative stress associated with steatosis.
- Antioxidant and anti-inflammatory response to curcumin supplementation in hemodialysis patients: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 34330457
12‑week curcumin raised antioxidant enzyme activities (catalase, GPx) in hemodialysis patients (direct antioxidant effect).
- Curcumin Nanomicelle Improves Lipid Profile, Stress Oxidative Factors and Inflammatory Markers in Patients Undergoing Coronary Elective Angioplasty; A Randomized Clinical Trial
PubMed ID: 33397249
Curcumin reduced MDA and improved SOD in coronary angioplasty patients (markers of oxidative stress improved).
- A Randomized, Placebo-Controlled Study to Evaluate the Effect of Bio-Enhanced Turmeric Formulation on Radiation-Induced Oral Mucositis
PubMed ID: 34161952
Reduced mucositis/dermatitis and pain during chemoradiotherapy likely reflect anti‑oxidant/anti‑inflammatory actions.
- Co-Administration of Iron and Bioavailable Curcumin Reduces Levels of Systemic Markers of Inflammation and Oxidative Stress in a Placebo-Controlled Randomised Study
PubMed ID: 35277071
Curcumin coadministered with oral iron prevented iron‑induced TBARS rise and lowered TNF in subgroups.
- The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial
PubMed ID: 38082237
TAC increased and hsCRP decreased with curcumin‑piperine; multiple oxidative/inflammatory improvements reported.
- The nano-micellar curcumin improves International Prostate Symptoms Score (IPSS) in patients with benign prostatic hyperplasia: a randomized clinical trial
PubMed ID: 37458774
Nano‑micellar curcumin lowered MDA (oxidative marker) in BPH patients — evidence of antioxidant action.
- The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 38699839
RA trial increased total antioxidant capacity and reduced oxidative stress markers (MDA) alongside clinical benefit.
- The effect of curcumin and high-content eicosapentaenoic acid supplementations in type 2 diabetes mellitus patients: a double-blinded randomized clinical trial
PubMed ID: 38589346
T2DM study showed increases in TAC and decreases in MDA — clear antioxidant marker improvements.
- Sustained Release of Liposomal Curcumin: Enhanced Periodontal Outcomes in Diabetic Patients
PubMed ID: 38953482
Periodontal study showed increased TAC and reduced inflammatory oxidative markers in treated groups.
- Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
PubMed ID: 40573083
12‑month MASLD trial improved antioxidant markers alongside reduced inflammation and liver fat.
- Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
PubMed ID: 41096556
Large 12‑month trial increased GPx/TAC and reduced oxidative stress with clinical liver improvements.
- Curcumin supplementation improves the clinical outcomes of patients with diabetes and atherosclerotic cardiovascular risk
PubMed ID: 40759997
Diabetes + ASCVD risk RCT reduced MDA (oxidative marker) and inflammatory markers.
- Nanomicelle curcumin improves oxidative stress, inflammatory markers, and assisted reproductive techniques outcomes in endometriosis cases: a randomized clinical trial
PubMed ID: 40088332
Endometriosis RCT increased serum TAC/CAT/SOD and lowered follicular MDA — strong antioxidant signal.
- Nano-curcumin supplementation in critically ill patients with sepsis: a randomized clinical trial investigating the inflammatory biomarkers, oxidative stress indices, endothelial function, clinical outcomes and nutritional status
PubMed ID: 35621073
Nanocurcumin reduced MDA and improved SOD/catalase/TAC in septic ICU patients (strong antioxidant biomarker changes).
- Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study
PubMed ID: 18588355
Curcumin reduced malondialdehyde and inflammatory markers in T2D, indicating antioxidant benefits.
- A Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled Study
PubMed ID: 30345312
Bioavailable curcumin increased SOD/GSH and lowered TBARS and inflammatory markers in chronic alcohol users (clear antioxidant effects).
- Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress
PubMed ID: 28070018
Improved NO bioavailability and reduced oxidative stress in older adults after bioavailable curcumin supplementation.
- Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes
PubMed ID: 27879642
Well‑conducted RCT in athletes showed large reductions in circulating AGE and MDA (markers of glycoxidation and lipid peroxidation) with curcumin+BSE.
- Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery
PubMed ID: 38901949
CABG patients receiving curcumin+piperine had increased total antioxidant capacity and reduced CRP — supports antioxidant activity in clinical setting.
- The dose-response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise-induced muscle damage in males
PubMed ID: 40781899
Dose‑response trial showed reduced oxidative stress markers (FORT/OSI) especially at higher dose — solid antioxidant evidence.
- Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial
PubMed ID: 22099425
Trial in chronic sulphur mustard–related skin disease showed changes in antioxidant enzyme markers alongside reduced pruritus.
- Curcuminoids modulate pro-oxidant-antioxidant balance but not the immune response to heat shock protein 27 and oxidized LDL in obese individuals
PubMed ID: 23494802
In obese subjects 1 g/day curcuminoids significantly reduced pro‑oxidant–antioxidant balance (PAB).
- Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial
PubMed ID: 25171552
Curcuminoids improved GSH and lowered MDA along with better respiratory QoL in sulfur‑mustard patients.
- Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial
PubMed ID: 24648302
Reduced oxidative‑stress and inflammatory markers in chemo patients indicate antioxidant benefit.
- Curcuminoids Target Decreasing Serum Adipocyte-fatty Acid Binding Protein Levels in Their Glucose-lowering Effect in Patients with Type 2 Diabetes
PubMed ID: 25374024
In T2D curcuminoids increased SOD and decreased inflammatory markers—robust antioxidant signal.
- Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis
PubMed ID: 25618800
8‑week RCT in metabolic syndrome showed increased SOD, decreased MDA and CRP—strong antioxidant marker effects.
- Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial
PubMed ID: 25688638
Curcuminoids increased SOD and GSH and lowered MDA in knee OA patients.
- Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
PubMed ID: 27043120
Highly bioavailable curcumin markedly improved antioxidant markers and reduced lipid peroxidation in a randomized pilot.
- Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study
PubMed ID: 26771294
Curcumin increased total antioxidant capacity in patients undergoing prostate radiotherapy (RCT).
- The Effect of Dietary Supplementation With Curcumin on Redox Status and Nrf2 Activation in Patients With Nondiabetic or Diabetic Proteinuric Chronic Kidney Disease: A Pilot Study
PubMed ID: 26915483
Curcumin attenuated lipid peroxidation and enhanced antioxidant capacity in proteinuric CKD patients (pilot RCT), though no renal functional change.
Blood circulation (38)
- The effect of curcumin-piperine supplementation on lipid profile, glycemic index, inflammation, and blood pressure in patients with type 2 diabetes mellitus and hypertriglyceridemia
PubMed ID: 39165011
T2DM trial with hypertriglyceridemia: curcumin+piperine lowered triglycerides and glucose — favorable cardiometabolic effects relevant to circulation.
- Curcumin supplementation improves the clinical outcomes of patients with diabetes and atherosclerotic cardiovascular risk
PubMed ID: 40759997
14‑week RCT in diabetics with ASCVD risk: significant SBP/DBP reductions and improved LDL/HDL.
- Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
PubMed ID: 41096556
Long‑term metabolic and liver improvements in obese T2DM support cardiovascular risk reduction.
- "The protective effect of nano curcumin supplementation on doxorubicin induced cardiotoxicity in breast cancer patients; a randomized, double-blind clinical trial"
PubMed ID: 39223927
Nanocurcumin preserved LVEF and prevented adverse LV remodeling during anthracycline therapy — direct cardiac protection.
- Nanocurcumin supplementation improves pulmonary function in severe COPD patients: A randomized, double blind, and placebo-controlled clinical trial
PubMed ID: 38178561
COPD RCT lowered systolic BP and IL‑6, indicating benefits to vascular parameters.
- The effect of curcumin and high-content eicosapentaenoic acid supplementations in type 2 diabetes mellitus patients: a double-blinded randomized clinical trial
PubMed ID: 38589346
T2DM study showed large triglyceride reductions and hs‑CRP lowering — favorable cardiometabolic/circulatory effects.
- Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized, placebo-controlled clinical trial
PubMed ID: 36799355
Curcumin+piperine reduced blood pressure and cholesterol in NAFLD patients (circulatory/metabolic benefit).
- Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study
PubMed ID: 22421908
Curcumin combined with endurance training improved central arterial load (aortic SBP and AIx) more than exercise alone.
- Curcumin extract for prevention of type 2 diabetes
PubMed ID: 22773702
Prevention of diabetes and improved glycemia in prediabetics supports vascular/metabolic health relevant to circulation.
- Effects of curcumin and/or coenzyme Q10 supplementation on metabolic control in subjects with metabolic syndrome: a randomized clinical trial
PubMed ID: 36192751
Curcumin (200 mg/day) in metabolic syndrome improved triglycerides, HDL and total cholesterol — lipid improvements supportive of healthier circulation.
- Effect of adding fenofibrate versus curcumin to glimepiride in patients with type 2 diabetes: a randomized controlled trial
PubMed ID: 40481568
Curcumin added to glimepiride improved glycemia and several lipid measures and lowered hs‑CRP, which can benefit vascular health.
- Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial
PubMed ID: 30796508
Phytosomal curcumin improved glycemia/lipids and lowered cortisol (metabolic effects supporting vascular health).
- Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress
PubMed ID: 28070018
Bioavailable curcumin improved resistance-artery endothelial function (+37% FBF_ACh) and brachial FMD (+36%) in older adults (strong circulation benefit).
- Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study
PubMed ID: 18588355
Curcumin (NCB-02) improved endothelial function and reduced oxidative/inflammatory markers vs placebo in T2D patients.
- Effect of Phytosomal Curcumin on Circulating Levels of Adiponectin and Leptin in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 31204416
Increased adiponectin and HDL in NAFLD patients — favorable markers for vascular health.
- Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial
PubMed ID: 28158893
Phytosomal curcumin reduced BMI/waist and improved liver fat — metabolic improvements that benefit circulation.
- Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial
PubMed ID: 22610853
One month of 1 g/day curcuminoids lowered triglycerides in obese adults, a favorable circulation/vascular risk effect.
- Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting
PubMed ID: 22481014
Perioperative curcuminoids significantly lowered in‑hospital MI incidence and decreased postoperative inflammatory/oxidative biomarkers.
- Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial
PubMed ID: 25440375
Lipid profile improvements (↓ LDL, ↑ HDL, ↓ TG) in metabolic syndrome support cardiovascular health.
- Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial
PubMed ID: 25131839
12‑week curcumin improved HDL and lowered LDL/triglycerides—beneficial for circulation/vascular risk.
- Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population
PubMed ID: 25277322
Lowered LDL and total cholesterol in older adults indicates improved circulatory risk profile.
- Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial
PubMed ID: 27124606
NAFLD trial found reductions in total cholesterol, LDL and triglycerides — favorable for circulation/vascular risk.
- Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial
PubMed ID: 27470399
Reduced circulating pro‑inflammatory cytokines (TNF‑α, IL‑6, MCP‑1) in metabolic syndrome, which is favorable for vascular health.
- Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial
PubMed ID: 28735818
Curcuminoids + piperine lowered total cholesterol, non‑HDL‑C and Lp(a) in type 2 diabetes, indicative of improved atherogenic lipid profile.
- Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial
PubMed ID: 29291429
Curcumin + phytosterols produced larger reductions in total and LDL cholesterol (improves lipid risk profile relevant to circulation/vascular health).
- Effects on oral fat load of a nutraceutical combination of fermented red rice, sterol esters and stanols, curcumin, and olive polyphenols: A randomized, placebo controlled trial
PubMed ID: 29655700
A multi‑ingredient nutraceutical containing curcumin improved lipids and endothelial adhesion markers (sICAM‑1/sVCAM‑1), supporting vascular/endothelial health (confounded by other ingredients).
- The Combined Effects of ω -3 Fatty Acids and Nano-Curcumin Supplementation on Intercellular Adhesion Molecule-1 (ICAM-1) Gene Expression and Serum Levels in Migraine Patients
PubMed ID: 29237386
Omega‑3 + nano‑curcumin reduced serum ICAM‑1 and migraine attacks, indicating reduced endothelial inflammation (circulatory marker improvement).
- Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus
PubMed ID: 31871950
Theracurmin prevented rise in oxidized‑LDL and improved some lipids in IGT/mild diabetes (favors vascular health).
- The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial
PubMed ID: 33200488
Nanocurcumin improved lipids (total and LDL) and antioxidant markers in diabetic foot ulcer patients (supports circulation).
- The Effects of Nano-curcumin on Metabolic Status in Patients With Diabetes on Hemodialysis, a Randomized, Double Blind, Placebo-controlled Trial
PubMed ID: 32655024
Nano‑curcumin in diabetic hemodialysis patients reduced fasting glucose, total cholesterol, LDL, TGs and hs‑CRP — beneficial cardio‑metabolic profile.
- Curcumin Nanomicelle Improves Lipid Profile, Stress Oxidative Factors and Inflammatory Markers in Patients Undergoing Coronary Elective Angioplasty; A Randomized Clinical Trial
PubMed ID: 33397249
Curcumin (especially nano‑curcumin) improved lipid profile, oxidative stress (MDA) and inflammatory markers in patients undergoing coronary angioplasty.
- The Effects of Curcumin Plus Piperine Supplementation in Patients with Acute Myocardial Infarction: A Randomized, Double-Blind, and Placebo-Controlled Trial
PubMed ID: 34981479
Post‑AMI trial showed modest improvements in HbA1c and lipids (LDL/HDL), relevant to circulation/vascular risk.
- The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 33861432
500 mg/day curcumin in metabolic syndrome improved pulse wave velocity (PWV) and reduced weight — direct arterial stiffness/circulation benefit.
- The effects of nano-curcumin supplementation on glycemic control, blood pressure, lipid profile, and insulin resistance in patients with the metabolic syndrome: A randomized, double-blind clinical trial
PubMed ID: 33851448
Nano‑curcumin significantly lowered triglycerides in metabolic syndrome patients (favourable vascular risk marker).
- Three months of combination therapy with nano-curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 35674733
Nano‑curcumin reduced hs‑CRP and Lp(a) in diabetics with CAD—markers relevant to cardiovascular risk/circulation.
- The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial
PubMed ID: 38082237
Curcumin‑piperine reduced CIMT, blood pressure and triglycerides vs placebo in stroke rehab patients.
- The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
PubMed ID: 39125322
Large 12‑month RCT showed reduced pulse wave velocity (arterial stiffness) and improvements in LDL/small‑dense LDL — strong circulation benefit.
- Effect of nano-curcumin supplementation on cardiometabolic risk factors, physical and psychological quality of life, and depression in patients with coronary slow flow phenomenon: a randomized double-blind clinical trial
PubMed ID: 39085864
In coronary slow flow patients, nano‑curcumin prevented glycemic deterioration and improved QoL/depression; relevant to cardiovascular status though sample small.
Digestive support (32)
- Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis - a randomized, placebo-controlled, pilot study
PubMed ID: 24011514
NCB‑02 (curcumin) enema added to 5‑ASA produced significantly better per‑protocol clinical/endoscopic outcomes in distal UC—direct colonic benefit.
- A Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled Study
PubMed ID: 30345312
Improvements in liver enzymes and antioxidant status in chronic alcohol users support digestive/hepatic health.
- Efficacy of Improvised Topical Zinc (1%) Ora-Base on Oral Mucositis during Cancer Chemo-Radiation-A Randomized Study
PubMed ID: 32350185
Topical multi-ingredient paste containing curcumin reduced oral mucositis severity (direct symptom relief in the oral/GI tract).
- Beneficial Effects on Abdominal Bloating with an Innovative Food-Grade Formulation of Curcuma longa and Boswellia serrata Extracts in Subjects with Irritable Bowel Syndrome and Small Bowel Dysbiosis
PubMed ID: 35276778
Large RCT in IBS with curcumin+Boswellia phytosome added to low‑FODMAP produced large, clinically relevant reductions in bloating and abdominal pain and lowered a dysbiosis marker.
- [The effect of chelidonium- and turmeric root extract on upper abdominal pain due to functional disorders of the biliary system. Results from a placebo-controlled double-blind study]
PubMed ID: 10495621
Pilot trial of Schöllkraut+curcuma extract showed faster pain relief in biliary dyskinesia, but combination product limits attribution to curcumin alone.
- Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial
PubMed ID: 17101300
Adjunct curcumin reduced relapse/improved indices in ulcerative colitis — directly supports improved digestive health.
- Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis in a Randomized Controlled Trial
PubMed ID: 25724700
Multicenter RCT: curcumin added to mesalamine produced high rates of clinical and endoscopic remission in UC—direct digestive health evidence.
- [Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study]
PubMed ID: 29378102
Jelly with inulin, curcumin and B6 improved stool frequency/form, pain and QoL in IBS‑C, though curcumin's independent contribution is unclear.
- Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome
PubMed ID: 27308645
Randomized trial of curcumin+fennel showed large, clinically meaningful reductions in IBS symptoms and pain.
- Evaluation of Benefit and Tolerability of IQP-CL-101 (Xanthofen) in the Symptomatic Improvement of Irritable Bowel Syndrome: A Double-Blinded, Randomised, Placebo-Controlled Clinical Trial
PubMed ID: 28508427
Curcuminoid‑containing multi‑ingredient product improved IBS severity and abdominal pain vs placebo (beneficial for digestive symptom control, but confounded formulation).
- The efficacy of curcuminoids in improvement of ulcerative colitis symptoms and patients' self-reported well-being: A randomized double-blind controlled trial
PubMed ID: 30132960
Nanocurcumin add‑on to mesalamine significantly improved SCCAI, urgency and symptoms in mild–moderate ulcerative colitis (direct digestive disease benefit).
- The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis
PubMed ID: 31802559
Curcumin improved clinical disease activity and QoL in mild–moderate ulcerative colitis (direct digestive symptom benefit).
- Highly Bioavailable Curcumin Derivative Ameliorates Crohn's Disease Symptoms: A Randomized, Double-Blind, Multicenter Study
PubMed ID: 32412598
Theracurmin improved clinical and endoscopic Crohn's disease indices vs placebo — strong digestive benefit.
- Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial
PubMed ID: 32147075
Curcuminoids improved NAFLD on ultrasound and reduced inflammatory cytokines — liver/digestive health support.
- Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study
PubMed ID: 33478482
RCT showed ~28% reduction in GI symptom score vs 18% placebo — direct evidence of improved digestive comfort.
- Effects of nanomicelle curcumin capsules on prevention and treatment of oral mucosits in patients under chemotherapy with or without head and neck radiotherapy: a randomized clinical trial
PubMed ID: 34521398
Nanomicelle curcumin reduced severity and pain of chemotherapy/radiotherapy‑induced oral mucositis (oral comfort / upper GI tract).
- Efficacy of Rose Bengal and Curcumin mediated photodynamic therapy for the treatment of denture stomatitis in patients with habitual cigarette smoking: A randomized controlled clinical trial
PubMed ID: 34087468
Curcumin photodynamic therapy reduced Candida counts and clinical signs in denture stomatitis (oral mucosal comfort).
- Novel Bioenhanced Curcumin With Mesalamine for Induction of Clinical and Endoscopic Remission in Mild-to-Moderate Ulcerative Colitis: A Randomized Double-Blind Placebo-controlled Pilot Study
PubMed ID: 32889959
Bioenhanced curcumin induced clinical and endoscopic remission in mild‑moderate ulcerative colitis (strong direct digestion benefit).
- Curcuma longa Linn versus omeprazole in treatment of functional dyspepsia: A randomized, double-blind, placebo-controlled trial
PubMed ID: 34652861
4‑week RCT showed clinically meaningful reduction in dyspepsia pain and non‑pain scores comparable to omeprazole.
- A Randomized, Placebo-Controlled Study to Evaluate the Effect of Bio-Enhanced Turmeric Formulation on Radiation-Induced Oral Mucositis
PubMed ID: 34161952
Large RCT in chemoradiotherapy patients showed marked reductions in oral mucositis, dysphagia and pain.
- Effect of Curcumin on Severity of Functional Dyspepsia: a Triple Blinded Clinical Trial
PubMed ID: 33861441
Adjunct curcumin plus famotidine reduced dyspepsia severity and H. pylori stool antigen.
- Comparative randomized trial study about the efficacy of photobiomodulation and curcumin antimicrobial photodynamic therapy as a coadjuvant treatment of oral mucositis in oncologic patients: antimicrobial, analgesic, and degree alteration effect
PubMed ID: 35608694
Curcumin photodynamic therapy reduced oral mucositis pain and improved healing vs control.
- COMPARATIVE EFFICACY OF 1% CURCUMIN NANOMICELLE GEL AND 2% CURCUMIN GEL FOR TREATMENT OF RECURRENT APHTHOUS STOMATITIS: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL
PubMed ID: 35718440
Topical nanomicelle curcumin gel produced faster pain relief and ulcer shrinkage.
- Effect of nanomicelle curcumin-based photodynamic therapy on the dynamics of white spot lesions and virulence of Streptococcus mutans in patients undergoing fixed orthodontic treatment: A randomized double-blind clinical trial
PubMed ID: 36602066
Oral antimicrobial photodynamic curcumin greatly reduced S. mutans and improved white-spot lesions (oral health).
- Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial
PubMed ID: 37696679
Large RCT in functional dyspepsia showed symptom improvements comparable to omeprazole.
- Curcumin-QingDai Combination for Patients With Active Ulcerative Colitis: A Randomized, Double-Blinded, Placebo-Controlled Trial
PubMed ID: 37302449
Curcumin+QingDai produced large symptomatic and endoscopic benefits in ulcerative colitis.
- Nano-curcumin supplementation in patients with mild and moderate acute pancreatitis: A randomized, placebo-controlled trial
PubMed ID: 37490939
Nano‑curcumin shortened hospital stay and improved appetite in acute pancreatitis.
- Impaired postprandial GLP-2 response enhances endotoxemia, systemic inflammation, and kidney injury in metabolic dysfunction-associated steatohepatitis (MASH): effect of phospholipid curcumin meriva
PubMed ID: 39620369
Meriva improved postprandial GLP‑2, reduced endotoxemia and gut permeability — strong mechanistic evidence for healthier digestion.
- Curcumin plus piperine improve body composition in patients with inflammatory bowel disease: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 39934549
IBD trial improved FFM and phase angle; in the context of IBD these imply improved nutritional/GI status.
- Curcumin Supplementation Improves Gastrointestinal Symptoms in Women with Severe Obesity: A Double-Blind, Randomized, Placebo-Controlled Trial-A Pilot Study
PubMed ID: 40647170
Randomized trial showed large, significant reductions in GSRS total and subdomains (eructation, constipation).
- Efficacy of curcumin supplementation for the treatment and prevention of pouchitis after ileal pouch-anal anastomosis: a randomized controlled trial
PubMed ID: 40295333
Large RCT showed curcumin reduced pouchitis activity and greatly increased maintenance remission—direct improvement in intestinal comfort/clinical digestive symptoms.
- Evaluation of oral nano-curcumin formulation effectiveness in patients with mild to moderate ulcerative colitis: a randomized, placebo-controlled, double-blind clinical trial
PubMed ID: 40820062
Adjunct nano‑curcumin improved clinical and endoscopic UC outcomes—strong evidence for intestinal/hepatic‑gut benefit.
Joint comfort (29)
- Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study
PubMed ID: 29316908
Large double‑blind RCT in knee osteoarthritis: curcumin (esp. with Boswellia) produced clinically meaningful pain reduction and better objective function tests.
- Efficacy of topical curcumin on mild to moderate carpal tunnel syndrome: a randomized double-blind, placebo-controlled clinical trial
PubMed ID: 38281082
Topical curcumin gel RCT for carpal tunnel: clinically meaningful symptom and functional improvement.
- The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 38699839
RA RCT (500 mg/day, 8 weeks) decreased DAS‑28, tender/swollen joint counts and pain — direct evidence for improved joint comfort.
- The Effect of a Dispersible Curcumin (HydroCurc®) Compared to a Placebo for Reducing Joint Pain in an Adult Population - A Randomised, Double-Blind Study
PubMed ID: 35477159
Two‑week RCT showed significant reductions in morning joint pain with a dispersible curcumin.
- Therapeutic Potential of Curcumin with and without Strengthening Exercises in Improving Rheumatoid Arthritis
PubMed ID: 36474395
RA trial combining curcumin with strengthening exercises produced larger reductions in pain/function scores vs curcumin alone.
- Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 35178811
8‑week RCT in RA women reduced inflammatory markers and improved metabolic/anthropometric measures; joint benefit plausible.
- Efficacy of Curcumin in Combination with Intralesional Dexamethasone with Hyaluronidase in the Treatment of Oral Submucous Fibrosis: A Randomized Controlled Trial
PubMed ID: 36172675
Significant improvements in interincisal opening and related measures indicate reduced soft‑tissue stiffness in the mouth.
- An Investigation into the Effects of a Curcumin Extract (Curcugen(®)) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study
PubMed ID: 35010916
Well‑powered RCT (Curcugen®) produced significant reductions in knee pain and improvements in objective functional performance in knee OA.
- Significant immunomodulatory properties of curcumin in patients with osteoarthritis; a successful clinical trial in Iran
PubMed ID: 32540725
Oral curcumin reduced VAS pain in OA and lowered CRP with immune cell effects.
- The Effect of Nanocurcumin in Improvement of Knee Osteoarthritis: A Randomized Clinical Trial
PubMed ID: 31868149
Nanomicelle curcumin improved WOMAC pain, stiffness and function in knee osteoarthritis in an RCT.
- A clinicobiochemical evaluation of curcumin as gel and as buccal mucoadhesive patches in the management of oral submucous fibrosis
PubMed ID: 33509742
Topical curcumin reduced burning and increased mouth opening in OSMF — reduced local tissue stiffness.
- The effect of curcumin ointment on knee pain in older adults with osteoarthritis: a randomized placebo trial
PubMed ID: 33032585
Topical curcumin ointment produced a clinically meaningful reduction in knee pain vs placebo at 6 weeks.
- Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study
PubMed ID: 31351488
Bio‑optimized curcumin reduced knee pain VAS and patient global scores in symptomatic knee osteoarthritis (direct joint benefit).
- Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study
PubMed ID: 30975196
Large RCT in knee OA: curcumin provided clinically meaningful pain relief comparable to diclofenac.
- A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study
PubMed ID: 28850308
Randomized DBPC trial in RA showed reduced CRP/ESR and clinically meaningful improvements in disease activity and pain scores after 90 days.
- Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study
PubMed ID: 25308211
Theracurmin RCT reduced knee pain and NSAID use over 8 weeks with good tolerability.
- Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial
PubMed ID: 24853120
Pilot RCT: 6 weeks of curcuminoids reduced knee OA pain and improved function versus placebo.
- Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study
PubMed ID: 24672232
Large RCT (n=367) found Curcuma domestica extract noninferior to ibuprofen for knee OA pain/function over 4 weeks.
- A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis
PubMed ID: 22407780
Small randomized trial in RA showed curcumin improved disease activity and outperformed diclofenac on symptom scores.
- The dose-response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise-induced muscle damage in males
PubMed ID: 40781899
Dose‑dependent reductions in soreness at 24–48 h support decreased perceived stiffness, especially at higher dose.
- A randomized, placebo-controlled, crossover clinical trial to evaluate the effect of a turmeric formulation on muscle soreness and function recovery in moderately active adults
PubMed ID: 41040018
Accelerated recovery from peak soreness and preserved torque indicate less stiffness and better short‑term muscular performance.
- A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner's dogs with osteoarthritis
PubMed ID: 29262825
Multi‑ingredient diet including curcuminoids improved subjective veterinary and owner pain scores in dogs with OA (objective gait not improved).
- Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study
PubMed ID: 32678677
Curcumagalactomannoside+glucosamine reduced OA pain and inflammatory markers more than chondroitin+glucosamine in a randomized trial.
- Influence of a low-dose supplementation of curcumagalactomannoside complex (CurQfen) in knee osteoarthritis: A randomized, open-labeled, active-controlled clinical trial
PubMed ID: 33210408
Curcumagalactomannoside improved pain, function and reduced inflammatory markers in OA versus active comparator.
- The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study
PubMed ID: 26937646
Bio‑curcumin plus glucosamine/chondroitin with exercise improved motion pain and algofunctional score in knee OA vs placebo+exercise.
- Effect of a combination of C. longa and B. serrata extracts on hand osteoarthritis. Results of a double-blind, randomized, placebo-controlled, multicenter trial
PubMed ID: 40554037
Standardized curcumin+Boswellia extract modestly but significantly reduced hand OA pain and improved patient global outcomes vs placebo.
- Herbal formulation "turmeric extract, black pepper, and ginger" versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial
PubMed ID: 32180294
Turmeric/black-pepper/ginger capsule lowered synovial PGE2 similar to naproxen in knee OA (anti-inflammatory effect relevant to joint comfort).
- The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial
PubMed ID: 40000988
Prevention of neuropathy may reduce stiffness-related functional impairment in children receiving vincristine.
- Effect of curcumin on fatigue and musculoskeletal health in postmenopausal women: a double-blind randomised controlled trial
PubMed ID: 40976665
Postmenopausal trial improved musculoskeletal health scores and reduced fatigue, relevant to joint‑related wellbeing.
Liver support (27)
- Effect of nano-curcumin supplementation on liver fibrosis in patients with NAFLD-associated fibrosis: a double-blind randomized controlled trial
PubMed ID: 41168313
Nano‑curcumin significantly lowered ALT/AST in NAFLD patients—direct clinical evidence of liver enzyme improvement (hepatic support).
- Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
PubMed ID: 41096556
Large 12‑month RCT in obese T2DM: robust reductions in liver fat/stiffness and improved antioxidant markers.
- Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
PubMed ID: 40573083
12‑month randomized trial in MASLD: significant reductions in CAP (steatosis) and liver stiffness and TNF.
- Impaired postprandial GLP-2 response enhances endotoxemia, systemic inflammation, and kidney injury in metabolic dysfunction-associated steatohepatitis (MASH): effect of phospholipid curcumin meriva
PubMed ID: 39620369
Meriva improved postprandial GLP‑2, reduced endotoxemia and was associated with CKD regression in metabolic steatohepatitis patients — mechanistic liver/gut benefit.
- Effect of phospholipid curcumin Meriva on liver histology and kidney disease in nonalcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial
PubMed ID: 38809154
Phospholipid curcumin (Meriva) RCT in biopsy‑proven NASH produced large histologic NASH resolution and fibrosis regression — robust liver support evidence.
- Curcumin supplementation alleviates hepatic fat content associated with modulation of gut microbiota-dependent bile acid metabolism in patients with nonalcoholic simple fatty liver disease: a randomized controlled trial
PubMed ID: 38795741
24‑week RCT in simple fatty liver reduced hepatic fat (CAP) and improved triglycerides and glycemia — strong fatty‑liver support.
- Curcumin and Piperine Combination for the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind Randomized Placebo-Controlled Trial
PubMed ID: 34981468
Curcumin+piperine reduced ALP and improved ultrasound NAFLD severity over 2 months (direct liver benefit).
- Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach
PubMed ID: 18720535
Large clinical trial with Curcuma‑containing herbal formulation dramatically reduced anti‑TB drug hepatotoxicity (multi‑herb product).
- Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial
PubMed ID: 28158893
Phytosomal curcumin markedly improved liver ultrasound steatosis and reduced transaminases, BMI and waist in NAFLD (8‑week RCT).
- Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial
PubMed ID: 29458218
T2D trial (curcuminoids+piperine) showed modest improvements in fasting glucose and ALT.
- An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: A double-blind randomized controlled clinical trial
PubMed ID: 29806132
In thalassemia major, curcumin reduced NTBI and modestly lowered ALT/AST (protective liver effect).
- Effect of Phytosomal Curcumin on Circulating Levels of Adiponectin and Leptin in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 31204416
Phytosomal curcumin increased adiponectin, lowered leptin and raised HDL in NAFLD — supportive of hepatic metabolic improvement.
- Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial
PubMed ID: 31168845
Curcuminoids+piperine improved NAFLD ultrasound severity and lowered ALT (within‑group effects).
- The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease
PubMed ID: 30610213
Curcumin plus lifestyle advice improved some liver fibrosis scores and enzymes, though weight loss accounted for much benefit.
- Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized, placebo-controlled clinical trial
PubMed ID: 36799355
Curcumin+piperine improved fasting glucose, total cholesterol and ALT in moderate-to-high NAFLD patients (supportive liver markers).
- A Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled Study
PubMed ID: 30345312
Bioavailable curcumin reduced ALT/GGT ~29–36% and improved antioxidant/liver markers in chronic alcohol users (strong hepatoprotective signal).
- A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial
PubMed ID: 30647436
Phospholipid curcumin produced distinct serum metabolomic changes in NAFLD patients (biochemical liver-related effects).
- A new nutraceutical (Livogen Plus®) improves liver steatosis in adults with non-alcoholic fatty liver disease
PubMed ID: 35986358
Multi-ingredient nutraceutical including curcumin reduced liver fat (CAP) and improved antioxidant potential (clinical liver-fat reduction).
- The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind, Randomized, Placebo-Controlled Trial
PubMed ID: 33861434
Low-dose phospholipid curcumin reduced hepatic steatosis grade and AST in NAFLD vs placebo (direct liver benefit).
- Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial
PubMed ID: 30796508
Phytosomal curcumin lowered GOT/GPT and improved glycemia/lipids in overweight subjects (hepatic enzyme improvements).
- Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial
PubMed ID: 27124606
Curcumin lowered total cholesterol, LDL and triglycerides in NAFLD — relevant to hepatic/metabolic health.
- Efficacy of phytosomal curcumin among patients with non-alcoholic fatty liver disease
PubMed ID: 31818232
Phytosomal curcumin reduced liver enzymes and oxidative damage markers in NAFLD (direct liver benefit).
- Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: A randomized controlled trial
PubMed ID: 32017253
Curcumin lowered validated cirrhosis severity scores (MELD, MELD‑Na, Child‑Pugh) vs placebo (strong liver‑specific benefit).
- Curcumin ameliorates health-related quality of life in patients with liver cirrhosis: A randomized, double-blind placebo-controlled trial
PubMed ID: 32147077
Improved quality-of-life scores in patients with liver cirrhosis (clinical liver population benefit).
- The Effects of Nano-curcumin on Metabolic Status in Patients With Diabetes on Hemodialysis, a Randomized, Double Blind, Placebo-controlled Trial
PubMed ID: 32655024
Improvements in metabolic/lipid markers in diabetic dialysis patients are supportive of hepatic metabolic health.
- Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial
PubMed ID: 32147075
Curcuminoid supplementation improved ultrasound‑assessed NAFLD severity and reduced weight and inflammatory cytokines — direct liver benefit.
- Curcumin Supplementation as a Preventive Strategy Against Tamoxifen-Induced Nonalcoholic Fatty Liver Disease in ER+ Breast Cancer Patients: A Triple-Blind Randomized Placebo-Controlled Trial
PubMed ID: 39948699
Tamoxifen‑associated NAFLD: curcumin reduced progression/severity of ultrasound‑detected steatosis vs placebo.
Joint mobility (26)
- A Comparative Study to Evaluate Efficacy of Curcumin and Aloe Vera Gel along with Oral Physiotherapy in the Management of Oral Submucous Fibrosis: A Randomized Clinical Trial
PubMed ID: 33576219
Curcumin gel plus physiotherapy improved mouth opening in oral submucous fibrosis (improved local mobility of oral tissues).
- Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study
PubMed ID: 29316908
Curcumin+Boswellia improved objective physical performance (chair stand, walk speed, TUG) in knee OA RCT.
- The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study
PubMed ID: 26937646
Curcumin formulation plus exercise improved motion pain and function (Lequesne Index) in knee OA.
- Influence of a low-dose supplementation of curcumagalactomannoside complex (CurQfen) in knee osteoarthritis: A randomized, open-labeled, active-controlled clinical trial
PubMed ID: 33210408
Large symptom and functional improvements (walking performance, KPS) reported with curcumagalactomannoside.
- Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study
PubMed ID: 32678677
Double‑blind randomized study showed meaningful improvements in pain and walking performance vs comparator.
- A randomized, placebo-controlled, crossover clinical trial to evaluate the effect of a turmeric formulation on muscle soreness and function recovery in moderately active adults
PubMed ID: 41040018
Preservation of short‑term muscle function and faster recovery from soreness implies improved functional mobility.
- The dose-response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise-induced muscle damage in males
PubMed ID: 40781899
Soreness reductions and functional signals at higher dose support potential mobility improvements post‑exercise.
- A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis
PubMed ID: 22407780
RA disease activity improvement suggests possible gains in mobility from reduced inflammation/pain.
- Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study
PubMed ID: 24672232
Curcuma domestica extract produced comparable improvements in WOMAC pain/function to ibuprofen, implying better mobility in knee OA.
- Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial
PubMed ID: 24853120
Knee OA pilot trial reported improved pain and function indices after curcumin.
- Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study
PubMed ID: 25308211
Theracurmin reduced knee pain and decreased NSAID need, supporting functional mobility gains.
- A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study
PubMed ID: 28850308
RA trial reported improved clinical scores that would be expected to translate into better mobility and function.
- Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study
PubMed ID: 30975196
Knee OA pain reduction (comparable to diclofenac) likely improves mobility and function.
- Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study
PubMed ID: 31351488
Curcumin reduced knee pain and patient global assessments in OA; likely to support improved function/mobility.
- The effect of curcumin ointment on knee pain in older adults with osteoarthritis: a randomized placebo trial
PubMed ID: 33032585
Topical curcumin reduced knee pain which commonly enables improved mobility.
- The Efficacy of the Novel Bioavailable Curcumin (Cureit) in the Management of Sarcopenia in Healthy Elderly Subjects: A Randomized, Placebo-Controlled, Double-Blind Clinical Study
PubMed ID: 33290142
Cureit produced small but positive changes in hand grip strength and walking time in sarcopenic elderly.
- A clinicobiochemical evaluation of curcumin as gel and as buccal mucoadhesive patches in the management of oral submucous fibrosis
PubMed ID: 33509742
Topical curcumin increased mouth opening in OSMF patients — localized mobility improvement.
- The Effect of Nanocurcumin in Improvement of Knee Osteoarthritis: A Randomized Clinical Trial
PubMed ID: 31868149
Nanocurcumin significantly improved WOMAC physical function in knee osteoarthritis — direct mobility benefit.
- Comparison of Efficacy of Topical Curcumin Gel with Triamcinolone-hyaluronidase Gel Individually and in Combination in the Treatment of Oral Submucous Fibrosis
PubMed ID: 32381807
Combination topical therapies including curcumin improved mouth opening in OSMF (functional mobility of jaw).
- An Investigation into the Effects of a Curcumin Extract (Curcugen(®)) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study
PubMed ID: 35010916
KOOS pain, timed up‑and‑go, 6‑min walk and JOA score improvements indicate clear functional and mobility gains in knee OA.
- Efficacy of Curcumin in Combination with Intralesional Dexamethasone with Hyaluronidase in the Treatment of Oral Submucous Fibrosis: A Randomized Controlled Trial
PubMed ID: 36172675
Oral submucous fibrosis trial showed significant improvements in mouth opening, cheek flexibility and tongue movement.
- Therapeutic Potential of Curcumin with and without Strengthening Exercises in Improving Rheumatoid Arthritis
PubMed ID: 36474395
RA patients receiving curcumin plus strengthening exercises had larger improvements in pain/function (mobility).
- The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 38699839
RA symptom and disease activity improvements are likely to translate into better mobility clinically.
- Efficacy of topical curcumin on mild to moderate carpal tunnel syndrome: a randomized double-blind, placebo-controlled clinical trial
PubMed ID: 38281082
Carpal tunnel RCT improved symptom severity and functional status (BCTQ FSS).
- The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial
PubMed ID: 40000988
Large pediatric RCT substantially reduced vincristine‑induced neuropathy, preserving motor function.
- Effect of curcumin on fatigue and musculoskeletal health in postmenopausal women: a double-blind randomised controlled trial
PubMed ID: 40976665
Postmenopausal musculoskeletal health improvements likely translate to better mobility and function.
Illness recovery (25)
- Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study
PubMed ID: 21671126
Post‑laparoscopic cholecystectomy curcumin reduced pain, fatigue and analgesic use markedly—consistent with faster symptomatic recovery.
- The dose-response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise-induced muscle damage in males
PubMed ID: 40781899
Dose‑response trial showed pronounced reductions in CK and oxidative stress and lowered soreness (strong recovery signals at higher dose).
- A randomized, placebo-controlled, crossover clinical trial to evaluate the effect of a turmeric formulation on muscle soreness and function recovery in moderately active adults
PubMed ID: 41040018
Randomized crossover trial with bioavailable turmeric improved recovery from maximal muscle soreness and preserved short‑term muscle function.
- Effectiveness of Ya-Samarn-Phlae in diabetic wound healing: Evidence from in vitro studies and a multicenter randomized controlled clinical trial
PubMed ID: 38373661
Adjunctive polyherbal (contains curcumin) markedly increased diabetic ulcer complete-healing rates and shortened time to healing.
- Nano-curcumin supplementation in critically ill patients with sepsis: a randomized clinical trial investigating the inflammatory biomarkers, oxidative stress indices, endothelial function, clinical outcomes and nutritional status
PubMed ID: 35621073
Nanocurcumin in sepsis shortened mechanical ventilation time and improved SOFA score (faster clinical recovery signals).
- The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial
PubMed ID: 40000988
Marked reduction in vincristine‑induced neuropathy supports faster functional recovery in pediatric ALL patients.
- Therapeutic effects of curcumin and piperine combination in critically ill patients with sepsis: a randomized double-blind controlled trial
PubMed ID: 40514680
Septic ICU trial associated with rapid CRP/ESR decreases consistent with faster biochemical recovery.
- "The protective effect of nano curcumin supplementation on doxorubicin induced cardiotoxicity in breast cancer patients; a randomized, double-blind clinical trial"
PubMed ID: 39223927
Nanocurcumin preserved LVEF during anthracycline exposure, reducing treatment‑related cardiac injury and aiding recovery.
- The effectiveness of phytosomal curcumin on clinical and laboratory parameters of patients with multiple trauma admitted to the intensive care unit: a double-blind randomized placebo-controlled trial
PubMed ID: 39289667
ICU trauma patients had faster neurological improvement (GCS) and inflammatory marker reductions over 7 days.
- Nano-curcumin supplementation in patients with mild and moderate acute pancreatitis: A randomized, placebo-controlled trial
PubMed ID: 37490939
Nano‑curcumin shortened hospital LOS and reduced analgesic needs in acute pancreatitis.
- Efficacy of curcumin for amelioration of radiotherapy-induced oral mucositis: a preliminary randomized controlled clinical trial
PubMed ID: 37069504
Curcumin (topical/oral) reduced mucositis severity and pain by week 3 vs placebo.
- Topical Turmeric Ointment in the Treatment of Diabetic Foot Ulcers: A Randomized, Placebo-Controlled Study
PubMed ID: 36514270
Topical turmeric significantly reduced diabetic foot ulcer size over five weeks (faster wound healing).
- A comparative study to assess the effectiveness of curcumin, mucosamin, and chlorhexidine in chemotherapy-induced oral mucositis
PubMed ID: 35577745
Chemotherapy mucositis trial showed faster healing and earlier ulcer improvement with curcumin.
- Effect of Nano-Curcumin on Radiotherapy-Induced Skin Reaction in Breast Cancer Patients: A Randomized, Triple-Blind, Placebo-Controlled Trial
PubMed ID: 35747962
Nano‑curcumin during radiotherapy reduced week‑7 severe dermatitis and patient‑reported pain.
- The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial
PubMed ID: 35668500
Outpatient COVID trial: higher weakness (fatigue) recovery rate with curcumin+piperine (clinical recovery signal).
- COMPARATIVE EFFICACY OF 1% CURCUMIN NANOMICELLE GEL AND 2% CURCUMIN GEL FOR TREATMENT OF RECURRENT APHTHOUS STOMATITIS: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL
PubMed ID: 35718440
Topical nanomicelle curcumin accelerated aphthous ulcer healing versus standard gel.
- Comparative randomized trial study about the efficacy of photobiomodulation and curcumin antimicrobial photodynamic therapy as a coadjuvant treatment of oral mucositis in oncologic patients: antimicrobial, analgesic, and degree alteration effect
PubMed ID: 35608694
Curcumin photodynamic therapy led to earlier mucositis improvement and reduced Candida counts.
- Analysis of Curcumin as a Radiosensitizer in Cancer Therapy with Serum Survivin Examination: Randomised Control Trial
PubMed ID: 33507691
Curcumin during radiotherapy in cervical cancer yielded greater biomarker reduction and higher complete response rates.
- A Randomized, Placebo-Controlled Study to Evaluate the Effect of Bio-Enhanced Turmeric Formulation on Radiation-Induced Oral Mucositis
PubMed ID: 34161952
Bio‑enhanced turmeric during chemoradiotherapy lowered severe mucositis/pain/dysphagia and weight loss versus placebo.
- Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients
PubMed ID: 33129099
Nano‑curcumin reduced proinflammatory cytokines and symptoms in hospitalized COVID‑19 patients and was associated with lower mortality.
- Efficacy of curcuminoids for reducing postoperative pain after laparoscopic gynecologic surgery: A pilot randomized trial
PubMed ID: 31150356
Postoperative curcuminoids reduced pain at 24 and 72 hours after laparoscopic surgery (faster symptomatic recovery).
- Eight Weeks of a High Dose of Curcumin Supplementation May Attenuate Performance Decrements Following Muscle-Damaging Exercise
PubMed ID: 31340534
Bioavailable curcumin attenuated immediate strength losses after muscle-damaging exercise (improves short-term recovery).
- Oral administration of nanomicelle curcumin in the prevention of radiotherapy-induced mucositis in head and neck cancers
PubMed ID: 30761565
Marked reduction in incidence/severity of radiotherapy-induced oral mucositis implies faster/less severe tissue injury course.
- The efficacy of curcumin in managing acute inflammation pain on the post-surgical removal of impacted third molars patients: A randomised controlled trial
PubMed ID: 29908031
Oral curcumin reduced acute post‑extraction pain and outperformed an NSAID — supports faster symptomatic recovery after surgery.
- Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting
PubMed ID: 22481014
Perioperative curcuminoids around CABG reduced MI incidence and postoperative inflammatory/oxidative markers—improved perioperative outcomes.
Mood balance (19)
- Curcumin Reduces Depression in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
PubMed ID: 39125295
Large year‑long RCT showed substantial reduction in PHQ‑9 depression scores and increased serum serotonin — strong mood‑enhancing evidence.
- Nanocurcumin as an Add-on to Antipsychotic Drugs for Treatment of Negative Symptoms in Patients With Chronic Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 33347019
Adjunctive nanocurcumin improved negative and overall psychotic symptoms in schizophrenia (mood/affect-related improvements).
- Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial
PubMed ID: 23832433
Randomized trial found curcumin produced depression score changes comparable to fluoxetine in a small sample—direct mood signal.
- Curcumin and major depression: a randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change
PubMed ID: 25523883
Biomarker changes in depressed cohort (substance P, thromboxane) and predictors of response support mood effects (exploratory).
- Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study
PubMed ID: 25046624
RCT showed modest antidepressant/mood benefits emerging after ~4–8 weeks.
- Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population
PubMed ID: 25277322
Mood improvements (reduced fatigue, increased calm/contentedness) reported in older adults after 4 weeks.
- Curcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double-blind, placebo-controlled trial
PubMed ID: 26051565
Large PMS trial showed substantial symptom reduction, including mood/behavior components.
- Effect of curcumin on serum brain-derived neurotrophic factor levels in women with premenstrual syndrome: A randomized, double-blind, placebo-controlled trial
PubMed ID: 26608718
Curcumin increased BDNF and reduced PMS symptom severity—strong biomarker + symptom mood evidence.
- An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial
PubMed ID: 25776839
Reduced anxiety scores in obese adults indicate a positive mood/affect effect.
- Chronic Supplementation of Curcumin Enhances the Efficacy of Antidepressants in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
PubMed ID: 26066335
Well‑powered RCT as adjunct to antidepressants produced significant reductions in depression scores with parallel biomarker changes (BDNF, cytokines, cortisol).
- Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
PubMed ID: 27043120
Bioavailable curcumin decreased stress and anxiety and fatigue in a randomized pilot, supporting mood benefits.
- Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study
PubMed ID: 27723543
Randomized trial found modest but significant reductions in depression and anxiety with curcumin (alone or with saffron).
- Add-on Treatment with Curcumin Has Antidepressive Effects in Thai Patients with Major Depression: Results of a Randomized Double-Blind Placebo-Controlled Study
PubMed ID: 29327213
Adjunctive curcumin reduced depression scores by ~12 weeks and was well tolerated — direct evidence for mood improvement.
- Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 31788880
Randomized trial in diabetic neuropathy showed statistically significant reductions in depression and anxiety scores with nano‑curcumin.
- An Exploratory Analysis of Changes in Mental Wellbeing Following Curcumin and Fish Oil Supplementation in Middle-Aged and Older Adults
PubMed ID: 32977404
Improved vigour and reduced subjective memory complaints indicate mood/psychological benefits in older adults.
- Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study
PubMed ID: 33478482
Large reduction in anxiety (DASS‑21) vs placebo — robust effect on affective symptoms.
- Effect of nano-curcumin supplementation on cardiometabolic risk factors, physical and psychological quality of life, and depression in patients with coronary slow flow phenomenon: a randomized double-blind clinical trial
PubMed ID: 39085864
In coronary slow flow patients, nano‑curcumin improved depression (BDI‑II) and QoL — clinically relevant mood benefit.
- Mental health and health-related quality of life response to curcumin-probiotic drink powder co-supplementation in adults with overweight/obesity and metabolic syndrome: a four-arm randomised, double-blind, placebo-controlled, clinical trial
PubMed ID: 40375569
Curcumin+probiotics reduced stress and anxiety and improved HRQOL in adults with metabolic syndrome—supports mood benefits though curcumin was combined with probiotics.
- The effect of curcumin on postpartum depression and anxiety in primiparous women: a double-blind randomized placebo-controlled clinical trial
PubMed ID: 40281561
Curcumin significantly reduced postpartum depression and anxiety scores in a double‑blind RCT—strong evidence for mood improvement.
Weight management (15)
- Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study
PubMed ID: 26592847
Bioavailable curcumin RCT showed meaningful increases in weight and fat loss, waist and BMI reductions in overweight metabolic syndrome subjects.
- Curcumin extract for prevention of type 2 diabetes
PubMed ID: 22773702
In prediabetics, curcumin prevented progression to diabetes and improved glycemic markers—strong metabolic benefit relevant to weight/metabolic control.
- Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial
PubMed ID: 30796508
Phytosomal curcumin improved fasting glucose, HOMA-IR and triglycerides (meaningful metabolic benefits supporting weight management).
- Curcumin and vitamin E improve hot flashes, lipid profile, and fasting blood glucose without any detrimental effect on the liver and renal function in postmenopausal women: A triple-blind placebo-controlled clinical trial
PubMed ID: 36053717
Curcumin improved fasting glucose and lipid profile in postmenopausal women (metabolic improvements relevant to weight control).
- Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial
PubMed ID: 33861440
Nano-curcumin added to metformin improved HOMA-IR and reduced LDL (metabolic improvements relevant to weight management).
- Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial
PubMed ID: 28158893
Phytosomal curcumin decreased BMI and waist circumference vs placebo in NAFLD patients.
- The Combined Effects of an Anti-Inflammatory Diet and Curcumin Supplementation on Thyroid Function and Lipid Profile in Patients With Hashimoto's Thyroiditis: A Double Blind Randomised Clinical Trial
PubMed ID: 41329567
In Hashimoto's patients curcumin reduced waist circumference over 12 weeks—direct evidence for modest central adiposity reduction (within study context).
- Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
PubMed ID: 41096556
12‑month obese T2DM RCT improved liver fat and glycemic control; metabolic benefits supportive of weight management.
- Effects of metformin and curcumin in women with polycystic ovary syndrome: A factorial clinical trial
PubMed ID: 39461199
PCOS factorial RCT: metformin + nanocurcumin produced larger weight/BMI reductions than either alone or placebo — direct weight‑support evidence.
- Curcumin supplementation reduces blood glucose and serum lipids of Brazilian women with high waist circumference: a randomized clinical trial
PubMed ID: 36155119
90‑day curcumin lowered triglycerides and total cholesterol and fasting glucose in women with large waist circumference.
- The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 33861432
Trial in metabolic syndrome reported significant weight reduction alongside improved PWV with 12 weeks of curcumin.
- Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial
PubMed ID: 32147075
Curcuminoid supplementation reduced weight and improved NAFLD in an RCT — direct weight management signal.
- Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial
PubMed ID: 30684965
Curcumin improved fasting insulin and insulin‑sensitivity markers in at‑risk adults — meaningful metabolic changes that can support weight management.
- Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus
PubMed ID: 29299989
Curcuminoids+piperine raised adiponectin and lowered leptin and TNF‑α in T2D, consistent with metabolic benefits relevant to weight control.
- Effects of supplementation with curcumin on serum adipokine concentrations: A randomized controlled trial
PubMed ID: 27297718
Curcumin increased adiponectin and tended to lower leptin in metabolic syndrome (RCT and meta‑analysis), supporting metabolic/weight regulation.
Mental clarity (14)
- Curcumin Reduces Depression in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
PubMed ID: 39125295
Large RCT showed marked reductions in depression and increased serotonin — may secondarily improve cognitive clarity.
- Effect and Safety of Phytosomal Curcumin Supplementation on Migraine Patients: A Randomized, Double-Blind and Placebo-Controlled Trial
PubMed ID: 41136816
Phytosomal curcumin reduced migraine frequency/severity and improved sleep/QoL—likely improves cognitive clarity impaired by headaches.
- Add-on Treatment with Curcumin Has Antidepressive Effects in Thai Patients with Major Depression: Results of a Randomized Double-Blind Placebo-Controlled Study
PubMed ID: 29327213
Adjunctive curcumin reduced depressive symptoms after ~12 weeks; improved mood can support perceived mental clarity (clinical effect on CNS symptoms).
- Curcumin as Add-On to Antipsychotic Treatment in Patients With Chronic Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 31045590
Adjunct curcumin improved overall and negative symptoms in schizophrenia, suggesting cognitive/clarity benefits.
- Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study
PubMed ID: 32512782
Lipidated curcumin improved working memory and spatial learning in healthy older adults (direct cognitive benefit).
- An Exploratory Analysis of Changes in Mental Wellbeing Following Curcumin and Fish Oil Supplementation in Middle-Aged and Older Adults
PubMed ID: 32977404
Randomized trial showed reduced subjective memory complaints and improved vigour in older adults.
- The effects of nano-curcumin supplementation on adipokines levels in obese and overweight patients with migraine: a double blind clinical trial study
PubMed ID: 35606882
Large RCT in migraine showed big reductions in attack frequency/duration, likely improving cognitive function/clarity.
- Efficacy of Curcumin on Cognitive Function Scores in Women with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 37119345
Triple‑blind RCT in women with PMS/dysmenorrhea showed improvements in memory, inhibitory control and total cognitive ability versus placebo.
- The effectiveness of phytosomal curcumin on clinical and laboratory parameters of patients with multiple trauma admitted to the intensive care unit: a double-blind randomized placebo-controlled trial
PubMed ID: 39289667
Improved GCS (consciousness) in ICU trauma patients indicates a direct benefit to level of consciousness/neurological status.
- Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study
PubMed ID: 25046624
RCT showed modest antidepressant/mood benefits emerging after 4–8 weeks, which can support mental clarity.
- The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial
PubMed ID: 31241007
Nano‑curcumin+CoQ10 reduced migraine frequency/severity/disability; fewer headaches can improve perceived mental clarity and cognitive function.
- Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial
PubMed ID: 29246725
18‑month RCT found improvements in verbal/visual memory and reduced brain amyloid/tau PET signal in non‑demented adults with bioavailable curcumin.
- Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults
PubMed ID: 27102361
12‑month RCT prevented a small decline on one cognitive screening test (MoCA) versus placebo in older adults.
- Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population
PubMed ID: 25277322
Solid‑lipid curcumin improved attention and working memory acutely and after 4 weeks in older adults.
Energy & Fatigue (11)
- Effects of Curcumin and Fenugreek Soluble Fiber on the Physical Working Capacity at the Fatigue Threshold, Peak Oxygen Consumption, and Time to Exhaustion
PubMed ID: 33044367
CUR+fenugreek increased neuromuscular fatigue threshold (PWCFT) — suggests improved sustainable power/energy.
- The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial
PubMed ID: 35668500
Significant improvement in patient‑reported weakness (fatigue) recovery in COVID outpatients with curcumin+piperine.
- Efficacy of Nanocurcumin as an Add-On Treatment for Patients Hospitalized with COVID-19: A Double-Blind, Randomized Clinical Trial
PubMed ID: 37547100
COVID RCT reported significant reductions in fatigue/myalgia — direct increase-in-energy signal during illness recovery.
- Curcumin Reduces Depression in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
PubMed ID: 39125295
Large trial showed major depression score improvements and increased serotonin — clinically likely to increase subjective energy.
- Randomised Clinical Trial Study: The Combination of Vitamin D and Curcumin Piperine Attenuates Disease Activity and Pro-inflammatory Cytokines Levels Insystemic Lupus Erythematosus Patients
PubMed ID: 38299416
SLE combination trial reduced fatigue (FSS) more with curcumin‑piperine + vitamin D — direct fatigue/energy benefit.
- Curcumin plus piperine improve body composition in patients with inflammatory bowel disease: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 39934549
IBD trial increased fat‑free mass and phase angle which correlate with improved functional energy/nutrition.
- Effect of curcumin on fatigue and musculoskeletal health in postmenopausal women: a double-blind randomised controlled trial
PubMed ID: 40976665
Primary outcome: clinically meaningful and significant reduction in fatigue in postmenopausal women.
- Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study
PubMed ID: 21671126
Postoperative study reported marked reductions in fatigue scores after curcumin—direct evidence for increased perceived energy.
- Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
PubMed ID: 27043120
Bioavailable curcumin reduced fatigue in stressed workers in a randomized double‑blind pilot.
- Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study
PubMed ID: 32512782
Significant reductions in fatigue (POMS) in older adults indicate increased perceived energy.
- An Exploratory Analysis of Changes in Mental Wellbeing Following Curcumin and Fish Oil Supplementation in Middle-Aged and Older Adults
PubMed ID: 32977404
Curcumin improved vigour (mood subscale) significantly in older adults — direct evidence for perceived energy increase.
Vitality (10)
- Combination therapy of curcumin and alendronate modulates bone turnover markers and enhances bone mineral density in postmenopausal women with osteoporosis
PubMed ID: 30304108
Curcumin added to alendronate produced greater reductions in bone turnover markers and larger increases in hip and total body BMD in postmenopausal women — relevant to age‑related skeletal vitality.
- Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress
PubMed ID: 28070018
Bioavailable curcumin improved endothelial function and NO bioavailability in middle-aged/older adults, relevant to age-related vascular vitality.
- Effect of curcumin on fatigue and musculoskeletal health in postmenopausal women: a double-blind randomised controlled trial
PubMed ID: 40976665
Postmenopausal women experienced less fatigue and better musculoskeletal health — supports vitality in aging group.
- The effectiveness of curcumin as a safe agent on hearing threshold improvement in patients with chronic kidney disease: a double-blind, placebo-controlled trial
PubMed ID: 39079962
Objective hearing improvements in CKD patients imply restoration of a key age-related sensory function and contribute to vitality/quality of life.
- Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial
PubMed ID: 39354480
12‑month metabolic improvements in obese T2DM (β‑cell, HOMA‑IR, HbA1c) support long‑term metabolic vitality in an aging population.
- The Efficacy of the Novel Bioavailable Curcumin (Cureit) in the Management of Sarcopenia in Healthy Elderly Subjects: A Randomized, Placebo-Controlled, Double-Blind Clinical Study
PubMed ID: 33290142
Small but positive gains in grip strength and walking time in sarcopenic elderly indicate functional vitality benefit.
- An Exploratory Analysis of Changes in Mental Wellbeing Following Curcumin and Fish Oil Supplementation in Middle-Aged and Older Adults
PubMed ID: 32977404
Older adults had improved vigour and fewer subjective memory complaints — supports age‑related vitality.
- Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study
PubMed ID: 32512782
Cognitive and fatigue improvements in older adults indicate better age‑related vitality/functional brain aging.
- Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol
PubMed ID: 31819387
Increased muscle and bone mass (combo product) in hemodialysis patients suggests improved age‑related functional vitality (combo).
- Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial
PubMed ID: 29246725
18‑month RCT demonstrated improvements in memory/attention and decreased amyloid/tau PET binding in non‑demented older adults.
Skin appearance (10)
- Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients
PubMed ID: 23745991
High‑dose oral curcumin markedly reduced radiation dermatitis severity and moist desquamation in breast radiotherapy patients.
- Efficacy of a mixed preparation containing piperine, capsaicin and curcumin in the treatment of alopecia areata
PubMed ID: 35318791
Topical preparation including curcumin produced significant hair regrowth vs baseline (cosmetic/skin appendage benefit), though combined with piperine and capsaicin.
- Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial
PubMed ID: 22099425
Randomized trial found clinically meaningful reductions in pruritus and related inflammatory/antioxidant markers in chronic skin disease — directly relevant to skin improvement.
- A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications
PubMed ID: 23038702
One‑gram/day curcumin improved inflammatory biomarkers and quality‑of‑life for chronic mustard‑induced itchy skin lesions.
- Topical Curcumin for Prevention of Radiation-Induced Dermatitis: A Pilot Double‑Blind, Placebo‑Controlled Trial
PubMed ID: 40145664
Topical 2% curcumin gel reduced radiation dermatitis redness, irritation, and pain in RCT—direct skin appearance and comfort benefit.
- Effectiveness of an Alcohol-Free Chitosan-Curcuminoid Mouthwash Compared with Chlorhexidine Mouthwash in Denture Stomatitis Treatment: A Randomized Trial
PubMed ID: 30758216
Topical curcuminoid mouthwash had higher complete-response rates for denture-related stomatitis vs chlorhexidine (topical mucosal benefit).
- Topical Turmeric Ointment in the Treatment of Diabetic Foot Ulcers: A Randomized, Placebo-Controlled Study
PubMed ID: 36514270
Topical turmeric significantly reduced diabetic foot ulcer size—clear topical wound‑healing benefit.
- Effect of Nano-Curcumin on Radiotherapy-Induced Skin Reaction in Breast Cancer Patients: A Randomized, Triple-Blind, Placebo-Controlled Trial
PubMed ID: 35747962
Nano‑curcumin during radiotherapy reduced severe radiation dermatitis and patient pain at week 7.
- Effects of hot water extract of Curcuma longa on human epidermal keratinocytes in vitro and skin conditions in healthy participants: A randomized, double-blind, placebo-controlled trial
PubMed ID: 30809971
Hot‑water Curcuma extract increased facial skin moisture across 8 weeks in healthy volunteers (direct cosmetic benefit).
- Oral Curcumin (Meriva) Is Effective as an Adjuvant Treatment and Is Able to Reduce IL-22 Serum Levels in Patients with Psoriasis Vulgaris
PubMed ID: 26090395
Bioavailable oral curcumin (Meriva) added to topical steroid significantly improved PASI and reduced IL‑22 in psoriasis (clinical skin benefit).
Focus & concentration (7)
- Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study
PubMed ID: 32512782
Curcumin improved working memory tasks (Serial Threes/Sevens) indicating better focus and attention.
- Effect and Safety of Phytosomal Curcumin Supplementation on Migraine Patients: A Randomized, Double-Blind and Placebo-Controlled Trial
PubMed ID: 41136816
Reduced migraine frequency/severity and improved sleep/QoL with phytosomal curcumin can restore attention and focus impaired by headaches.
- Efficacy of Curcumin on Cognitive Function Scores in Women with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 37119345
Trial reported improvements in selective attention and inhibitory control (specific focus-related cognitive domains).
- An Exploratory Analysis of Changes in Mental Wellbeing Following Curcumin and Fish Oil Supplementation in Middle-Aged and Older Adults
PubMed ID: 32977404
Reduced subjective memory complaints and improved vigour likely support attentional focus in older adults.
- Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population
PubMed ID: 25277322
Clear improvements in sustained attention and working memory acutely and after 4 weeks in older adults.
- Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial
PubMed ID: 29246725
Long RCT showed improvements in memory/attention tasks and brain PET measures with bioavailable curcumin, supporting focus/attention.
- The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial
PubMed ID: 31241007
Combination trial (nano‑curcumin+CoQ10) reduced migraine burden; reductions in headaches can improve ability to focus and cognitive performance.
Similar by evidence
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Products with Curcumin
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Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.