White Mulberry
16 benefits mapped to clinical evidence across supplements.
Dose per serving from research
40 study groups in 20 studies say how much White Mulberry participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 100 mg to 250 mg, 23% of 40 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg to 10 mg | 3 |
| 10 mg to 25 mg | 2 |
| 25 mg to 50 mg | 4 |
| 50 mg to 100 mg | 0 |
| 100 mg to 250 mg | 9 |
| 250 mg to 500 mg | 6 |
| 500 mg to 1 g | 8 |
| 1 g to 2.5 g | 5 |
| 2.5 g to 5 g | 2 |
| over 5 g | 1 |
Benefit Evidence
Inflammation ↓ CRP -1.94
Inflammation ↓ markers
Inflammation ↓ healing score
CRP −1.03; inflammation down
Inflammation attenuated; markers improved
LDL -22%
TG -37 mg/dL
LDL/TC down -21.9%
HDL up, LDL down
Glucose/HbA1c down
Mucositis reduced; HR 0.63
Healing faster; -3 days
Pocket depth improved; -0.18 mm
Pocket depth -0.18 mm
Plaque, gingiva unchanged
Vascularity/pigment ↓
MASI −1.2
Wrinkles −17%
Pigmentation −12%
Wrinkles/smoothness +14%
Glucose control, fewer GI events
-11% post‑meal glucose
Starch absorption -19%
Sugar absorption, insulin
Blood pressure -10/6
Lipids/glucose/inflammation lower
Arteries/events improved
BP, TG, CRP -10/-14
LDL, glucose, HbA1c -22%
BP -10/6 mmHg
IMT/events lower
Glucose/stiffness lower
BP, TG, CRP −9.7
LDL, glucose, HbA1c −21.9%
Skin lesions improved
S. aureus inhibited
Blood pressure −9.67 mmHg
Inflammation marker −1.03 mg/L
Triglycerides −14.22 mg/dL
Wrinkles/smoothness: −16.6%
Plumping: +13.4%
Pigmentation: MASI -1.2
Wrinkles/smoothness: -16.6%
Inflammation ↓ CRP -1.94
Inflammation ↓ markers
Inflammation ↓ healing score
CRP −1.03; inflammation down
Inflammation attenuated; markers improved
Mucositis reduced; HR 0.63
Healing faster; -3 days
Pocket depth improved; -0.18 mm
Pocket depth -0.18 mm
Plaque, gingiva unchanged
Vascularity/pigment ↓
MASI −1.2
Wrinkles −17%
Pigmentation −12%
Wrinkles/smoothness +14%
Glucose control, fewer GI events
-11% post‑meal glucose
Starch absorption -19%
Sugar absorption, insulin
Blood pressure -10/6
Lipids/glucose/inflammation lower
Arteries/events improved
BP, TG, CRP -10/-14
LDL, glucose, HbA1c -22%
BP -10/6 mmHg
IMT/events lower
Glucose/stiffness lower
BP, TG, CRP −9.7
LDL, glucose, HbA1c −21.9%
Skin lesions improved
S. aureus inhibited
Blood pressure −9.67 mmHg
Inflammation marker −1.03 mg/L
Triglycerides −14.22 mg/dL
Wrinkles/smoothness: −16.6%
Plumping: +13.4%
Pigmentation: MASI -1.2
Wrinkles/smoothness: -16.6%
Research sources
Blood sugar (18)
- Dual modulation of lipid and glucose metabolism by a nutraceutical combination in patients at cardiometabolic risk: results from a multicenter randomized controlled trial
PubMed ID: 41044582
Multicenter nutraceutical trial (post‑hoc) reported larger drops in fasting glucose and HbA1c when Morus alba was included—supports chronic glycemic benefits (post‑hoc).
- Bioequivalence of Mulberry Fruit Extract and 1-Deoxynojirimycin for Postprandial Blood Glucose Lowering: A Randomized Trial in Humans
PubMed ID: 40419090
Large bioequivalence RCT showed mulberry extract and DNJ both reduced 2‑hr PPG; full extract showed somewhat greater metabolic effects—strong support.
- Mulberry leaves and water chestnut tea reduces postprandial blood glucose in borderline diabetic Japanese: A randomized, double-blind, placebo-controlled crossover study
PubMed ID: 40134056
Mulberry leaf + water chestnut tea lowered 30–60 min glucose and reduced insulin over 2 hours in borderline diabetics—small RCT with clear short‑term benefits.
- Mulberry leaf extract combined with tryptophan improves sleep and post wake mood in adults with sleep complaints - A randomized cross-over study
PubMed ID: 40072601
14‑day evening supplement including mulberry leaf reduced evening postprandial glucose iAUC by ~21% — acute glycemic benefit in randomized crossover setting (multi‑ingredient).
- A Synergistic Formulation of Plant Extracts Decreases Postprandial Glucose and Insulin Peaks: Results from Two Randomized, Controlled, Cross-Over Studies Using Real-World Meals
PubMed ID: 30044398
Two randomized double‑blind crossover studies (combined n large) showed consistent reductions in early postprandial glucose and insulin with a mulberry‑containing product.
- Evaluation of the Postprandial-Hyperglycemia-Suppressing Effects and Safety of Short-Term Intake of Mulberry Leaf and Water Chestnut Tea: A Randomized Double-Blind Placebo-Controlled Crossover Trial
PubMed ID: 40732933
Randomized crossover with CGM showed 2 weeks of mulberry+water chestnut tea reduced glycemic variability and early postprandial glucose.
- Mulberry leaf extract improves postprandial glucose response in prediabetic subjects: a randomized, double-blind placebo-controlled trial
PubMed ID: 25343729
4‑week RCT in impaired fasting glucose lowered postprandial glucose and insulin significantly.
- Mulberry-extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: Results of a randomised double-blind placebo-controlled study
PubMed ID: 28225835
Double‑blind crossover healthy adult study showed clear dose‑response reduction in postprandial glucose and insulin.
- Efficacy and Safety of Mulberry Twig Alkaloids Tablet for the Treatment of Type 2 Diabetes: A Multicenter, Randomized, Double-Blind, Double-Dummy, and Parallel Controlled Clinical Trial
PubMed ID: 33832957
Large multicenter RCT (n=600) showed non‑inferior and robust HbA1c lowering vs acarbose with good safety.
- Effect of Mori ramulus on the postprandial blood glucose levels and inflammatory responses of healthy subjects subjected to an oral high-fat/sucrose challenge: A double-blind, randomized, crossover clinical trial
PubMed ID: 34923339
Single dose Mori ramulus reduced late postprandial glucose and modulated insulin after high‑fat/sucrose challenge.
- Efficacy and Safety of Mulberry Twig Alkaloids Tablet for Treatment of Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Study
PubMed ID: 35048240
Multicenter placebo‑controlled RCT (n=200) showed clinically meaningful HbA1c reduction vs placebo.
- Dose-response efficacy of mulberry fruit extract for reducing post-prandial blood glucose and insulin responses: randomised trial evidence in healthy adults
PubMed ID: 35272722
Two randomized trials showed dose‑dependent, reproducible PPG and insulin reductions in healthy adults.
- Effect of Different Nutritional Supplements on Glucose Response of Complete Meals in Two Crossover Studies
PubMed ID: 35807854
Crossover study (n=30) showed strong reductions in 2‑hour iAUC and peak glucose; timing effects characterized.
- Effects of mulberry twig alkaloids(Sangzhi alkaloids) and metformin on blood glucose fluctuations in combination with premixed insulin-treated patients with type 2 diabetes
PubMed ID: 38027146
12‑week add‑on SZ‑A to insulin improved mean glucose, variability and reduced insulin dose in T2D on insulin.
- Effect of mulberry fruit extract on post-prandial glycaemic and insulinemic responses to different rice types: a randomised trial in healthy adults
PubMed ID: 37272629
Large crossover (n=120) showed 0.37 g mulberry fruit extract reduced 2‑h PPG ≈11% across rice types.
- The impact of mulberry leaf extract at three different levels on reducing the glycemic index of white bread
PubMed ID: 37561734
ISO‑standard GI testing showed dose‑dependent GI reductions up to ~44% with mulberry leaf extract—high‑quality evidence of glucose modulation.
- Understanding the Impact of Different Doses of Reducose(®) Mulberry Leaf Extract on Blood Glucose and Insulin Responses after Eating a Complex Meal: Results from a Double-Blind, Randomised, Crossover Trial
PubMed ID: 38892603
Double‑blind randomized crossover (Reducose®) cut 2‑hr glucose and insulin iAUC by ~30% across doses—strong clinical evidence for glycemic lowering.
- A Novel Nutraceutical Supplement Lowers Postprandial Glucose and Insulin Levels upon a Carbohydrate-Rich Meal or Sucrose Drink Intake in Healthy Individuals-A Randomized, Placebo-Controlled, Crossover Feeding Study
PubMed ID: 39064681
Large randomized crossover with mulberry+apple peel halved early postprandial glucose and substantially lowered insulin—robust glycemic effect.
Metabolism (5)
- A Synergistic Formulation of Plant Extracts Decreases Postprandial Glucose and Insulin Peaks: Results from Two Randomized, Controlled, Cross-Over Studies Using Real-World Meals
PubMed ID: 30044398
Two crossover studies showed reduced postprandial glucose and insulin with a multi-extract product containing white mulberry.
- Effect of Mori ramulus on the postprandial blood glucose levels and inflammatory responses of healthy subjects subjected to an oral high-fat/sucrose challenge: A double-blind, randomized, crossover clinical trial
PubMed ID: 34923339
Single-dose Mori ramulus modified late post-meal glucose/insulin kinetics after high-fat/sucrose challenge.
- Effect of Different Nutritional Supplements on Glucose Response of Complete Meals in Two Crossover Studies
PubMed ID: 35807854
Two crossover studies showed substantial (≈26–34%) reductions in 2‑h postprandial glucose iAUC with mulberry leaf extract.
- Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial
PubMed ID: 35623877
12-week RCT in T2DM showed reductions in insulin and improved HDL and oxidative stress markers (metabolic improvement).
- A Novel Nutraceutical Supplement Lowers Postprandial Glucose and Insulin Levels upon a Carbohydrate-Rich Meal or Sucrose Drink Intake in Healthy Individuals-A Randomized, Placebo-Controlled, Crossover Feeding Study
PubMed ID: 39064681
Mulberry+apple-peel tablet strongly reduced early postprandial glucose and insulin spikes (large effect but combination product).
Mood balance (4)
- Effect of Single Administration of Mulberry Milk on the Cognitive Function of 6-12-Year-Old Children: Results from a Randomized, Placebo-Controlled, Crossover Study
PubMed ID: 32685097
Single‑dose mulberry milk acutely reduced salivary cortisol and improved attention — supports short‑term stress/mood effects in children.
- The Positive Modulation Effect of a 6-Week Consumption of an Anthocyanin-Rich Mulberry Milk on Working Memory, Cholinergic, and Monoaminergic Functions in Healthy Working-Age Adults
PubMed ID: 34484562
6‑week study showed decreased salivary cortisol and improved cognition; cortisol reduction indicates stress modulation with possible mood benefits.
- Mulberry leaf extract combined with tryptophan improves sleep and post wake mood in adults with sleep complaints - A randomized cross-over study
PubMed ID: 40072601
14‑day evening supplement including mulberry leaf plus tryptophan shortened sleep latency and improved next‑day mood scores (randomized crossover), indicating mood/sleep‑related benefits.
- Randomized double-blind placebo-controlled trial of the effect of Morus nigra L. (black mulberry) leaf powder on symptoms and quality of life among climacteric women
PubMed ID: 31736077
Black mulberry leaf powder reduced menopausal symptom scores and improved several QoL/mental‑health domains in a small RCT.
Energy & Fatigue (4)
- Evaluation of the Postprandial-Hyperglycemia-Suppressing Effects and Safety of Short-Term Intake of Mulberry Leaf and Water Chestnut Tea: A Randomized Double-Blind Placebo-Controlled Crossover Trial
PubMed ID: 40732933
Mulberry+water-chestnut tea reduced 1‑h post-meal glucose peak and short-term glycemic variability.
- A Novel Nutraceutical Supplement Lowers Postprandial Glucose and Insulin Levels upon a Carbohydrate-Rich Meal or Sucrose Drink Intake in Healthy Individuals-A Randomized, Placebo-Controlled, Crossover Feeding Study
PubMed ID: 39064681
Large crossover trial showed ≈40–50% reductions in early postprandial glucose/insulin (blend product).
- Effect of Different Nutritional Supplements on Glucose Response of Complete Meals in Two Crossover Studies
PubMed ID: 35807854
Multiple controlled crossover studies with CGM showed strong reductions in 2‑h postprandial glucose iAUC (best evidence for steady post-meal glycemia).
- A Synergistic Formulation of Plant Extracts Decreases Postprandial Glucose and Insulin Peaks: Results from Two Randomized, Controlled, Cross-Over Studies Using Real-World Meals
PubMed ID: 30044398
Two crossover studies showed reduced early postprandial glucose and insulin with a formula containing white mulberry.
Inflammation (4)
- Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial
PubMed ID: 35623877
Lowered MDA and improved metabolic markers in T2DM are consistent with reduced oxidative/inflammatory stress.
- Effect of Mori ramulus on the postprandial blood glucose levels and inflammatory responses of healthy subjects subjected to an oral high-fat/sucrose challenge: A double-blind, randomized, crossover clinical trial
PubMed ID: 34923339
Attenuation of inflammatory markers after a metabolic challenge suggests anti-inflammatory activity.
- The Effect of Oral Care with Black Mulberry Syrup on Oral Mucositis in Patients With COPD: A Mixed Study
PubMed ID: 33421045
Black mulberry syrup sped healing of oral mucositis in COPD patients—reduced local inflammatory mucosal injury.
- Mulberry's healing Touch: Exploring ethnobotanical roots and medicinal potentials in the treatment of atopic dermatitis
PubMed ID: 39442826
Topical mulberry improved eczema lesions and shifted inflammatory/biomarker profiles toward normal in an open study—signals anti‑inflammatory effects on skin.
Cholesterol (3)
- Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial
PubMed ID: 35623877
T2D RCT reported a significant increase in HDL with Morus alba extract.
- Metabolic Response to Mulberry Extract Supplementation in Patients With Diabetic Nephropathy: a Randomized Controlled Trial
PubMed ID: 29190604
Trial in diabetic nephropathy showed a meaningful triglyceride reduction and small HDL rise — favorable lipid changes.
- Dual modulation of lipid and glucose metabolism by a nutraceutical combination in patients at cardiometabolic risk: results from a multicenter randomized controlled trial
PubMed ID: 41044582
Multicenter trial showed larger LDL‑C reductions when Morus alba was added to the nutraceutical mix (F2 vs F1), a robust lipid benefit signal.
Oral health (3)
- Effectiveness of Black Mulberry Molasses in Prevention of Radiotherapy-Induced Oral Mucositis: A Randomized Controlled Study in Head and Neck Cancer Patients
PubMed ID: 28677999
RCT showed black mulberry molasses reduced incidence/severity of radiation‑induced oral mucositis in head & neck cancer patients.
- Comparison of the effectiveness of Morus alba and chlorhexidine gels as an adjunct to scaling and root planing on stage II periodontitis - A randomized controlled clinical trial
PubMed ID: 38225885
Large RCT applying Morus alba gel after dental cleaning produced a small but significant reduction in periodontal pocket depth—modest periodontal benefit.
- The Effect of Oral Care with Black Mulberry Syrup on Oral Mucositis in Patients With COPD: A Mixed Study
PubMed ID: 33421045
Randomized study: black mulberry syrup gargle/swallow sped healing of mouth ulcers in COPD patients by ~3 days and reduced mucositis scores—direct oral mucosal benefit.
Skin health (3)
- A comparative study of the safety and efficacy of 75% mulberry (Morus alba) extract oil versus placebo as a topical treatment for melasma: a randomized, single-blind, placebo-controlled trial
PubMed ID: 22052272
Topical mulberry oil significantly improved melasma severity, melanin index, and quality-of-life measures.
- Adding herbal extracts to silicone gel on post-sternotomy scar: a prospective randomised double-blind study
PubMed ID: 32279615
Topical silicone gel combined with multi‑herb extract including paper mulberry modestly improved scar vascularity and pigmentation after sternotomy (small study, multi‑ingredient).
- Mulberry's healing Touch: Exploring ethnobotanical roots and medicinal potentials in the treatment of atopic dermatitis
PubMed ID: 39442826
Topical mulberry fruit extract improved eczema lesions and related biomarkers in a clinical application—strongest direct skin benefit among listed studies.
Digestive support (2)
- Efficacy and Safety of Mulberry Twig Alkaloids Tablet for the Treatment of Type 2 Diabetes: A Multicenter, Randomized, Double-Blind, Double-Dummy, and Parallel Controlled Clinical Trial
PubMed ID: 33832957
SZ‑A (mulberry twig alkaloids) caused fewer gastrointestinal adverse events than acarbose in large RCT.
- The impact of mulberry leaf extract at three different levels on reducing the glycemic index of white bread
PubMed ID: 37561734
Mulberry leaf extract dose‑dependently reduced white bread GI, implying altered carbohydrate processing and potential digestive comfort.
Heart health (2)
- Metabolic Response to Mulberry Extract Supplementation in Patients With Diabetic Nephropathy: a Randomized Controlled Trial
PubMed ID: 29190604
In diabetic nephropathy, mulberry extract reduced triglycerides and slightly raised HDL — lipid changes relevant to heart health.
- Dual modulation of lipid and glucose metabolism by a nutraceutical combination in patients at cardiometabolic risk: results from a multicenter randomized controlled trial
PubMed ID: 41044582
Addition of Morus alba to a nutraceutical produced larger LDL‑C reductions and modest glycemic improvements in a large multicenter trial—direct heart risk factor benefits.
Mental clarity (2)
- Effect of Single Administration of Mulberry Milk on the Cognitive Function of 6-12-Year-Old Children: Results from a Randomized, Placebo-Controlled, Crossover Study
PubMed ID: 32685097
Single‑dose RCT crossover in schoolchildren: anthocyanin‑rich mulberry milk reduced salivary cortisol and improved attention (ERP N100) and working memory speed acutely.
- The Positive Modulation Effect of a 6-Week Consumption of an Anthocyanin-Rich Mulberry Milk on Working Memory, Cholinergic, and Monoaminergic Functions in Healthy Working-Age Adults
PubMed ID: 34484562
Six‑week randomized study in working‑age adults showed improved attention and working memory and lowered salivary cortisol with anthocyanin‑rich mulberry milk.
Antioxidant (2)
- Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial
PubMed ID: 35623877
Significant decrease in MDA (oxidative stress marker) after 12 weeks indicates antioxidant activity.
- Metabolic Response to Mulberry Extract Supplementation in Patients With Diabetic Nephropathy: a Randomized Controlled Trial
PubMed ID: 29190604
Randomized trial in diabetic nephropathy showed large increase in glutathione (antioxidant) vs placebo.
Blood circulation (1)
- Dual modulation of lipid and glucose metabolism by a nutraceutical combination in patients at cardiometabolic risk: results from a multicenter randomized controlled trial
PubMed ID: 41044582
Large trial showed greater LDL reductions when Morus alba was included in a lipid-lowering nutraceutical.
Immune support (1)
- Mulberry's healing Touch: Exploring ethnobotanical roots and medicinal potentials in the treatment of atopic dermatitis
PubMed ID: 39442826
Topical mulberry extract improved eczema lesions and inhibited S. aureus in vitro—evidence of antimicrobial/immune‑related skin effects.
Healthy aging (1)
- A comparative study of the safety and efficacy of 75% mulberry (Morus alba) extract oil versus placebo as a topical treatment for melasma: a randomized, single-blind, placebo-controlled trial
PubMed ID: 22052272
Topical mulberry oil improved melasma severity and skin quality of life, relevant to skin aging/appearance.
Bone health (1)
- A Double-Blind Placebo-Controlled Randomized Trial Evaluating the Effect of Polyphenol-Rich Herbal Congee on Bone Turnover Markers of the Perimenopausal and Menopausal Women
PubMed ID: 30584459
8‑week randomized trial in menopausal women showed increased bone formation markers (osteocalcin, ALP) and decreased resorption marker (beta‑CTX) with polyphenol congee containing mulberry.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with White Mulberry
Search all61 products whose verified label declares White Mulberry — not every bottle that mentions it in a title.