Alpha-Ketoglutarate
10 benefits mapped to clinical evidence across supplements.
Dose per serving from products
68 products in our catalogue print how much Alpha-Ketoglutarate a serving holds.
Most common: 250 mg to 500 mg, 25% of 68 products.
| Dose per serving | Products |
|---|---|
| 10 mg or less | 2 |
| 10 mg to 25 mg | 6 |
| 25 mg to 50 mg | 6 |
| 50 mg to 100 mg | 7 |
| 100 mg to 250 mg | 11 |
| 250 mg to 500 mg | 17 |
| 500 mg to 1 g | 13 |
| 1 g to 2.5 g | 6 |
Dose per serving from research
6 study groups in 5 studies say how much Alpha-Ketoglutarate participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 g to 10 g, 50% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 1 g to 2.5 g | 2 |
| 2.5 g to 5 g | 0 |
| 5 g to 10 g | 3 |
| 10 g to 25 g | 1 |
Benefit Evidence
Protein anabolism +20%
Less catabolism; faster healing
Better strength/power
Research sources
Muscle growth (7)
- Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men
PubMed ID: 16928472
AAKG increased 1RM bench and peak power though body composition unchangedāsome functional support of muscle performance.
- Ornithine alpha-ketoglutarate improves wound healing in severe burn patients: a prospective randomized double-blind trial versus isonitrogenous controls
PubMed ID: 10890617
Severe burn trial with faster wound healing and reduced biochemical catabolismāevidence of improved protein economy.
- A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects
PubMed ID: 7976777
Elderly trial: OKG/ornithine caused weight gain and improved functional independenceāconsistent with preservation/improvement of lean mass or nutrition.
- Glutamine and alpha-ketoglutarate prevent the decrease in muscle free glutamine concentration and influence protein synthesis after total hip replacement
PubMed ID: 7666798
AKG prevented postoperative decline in muscle glutamine and total ribosomesāmarkers of preserved protein synthetic capacity.
- A randomized controlled trial of the influence of the mode of enteral ornithine alpha-ketoglutarate administration in burn patients
PubMed ID: 9482764
Enteral OKG improved nitrogen balance and reduced urinary 3āmethylhistidine (muscle breakdown) in burnsāclear proteināsparing effect.
- Nutritional and clinical efficacy of ornithine alpha-ketoglutarate in severe burn patients
PubMed ID: 10601539
Large burn RCT: substantially improved cumulated nitrogen balance and prealbuminārobust clinical support for increased protein anabolism.
- Impact of infant protein supply and other early life factors on plasma metabolome at 5.5 and 8 years of age: a randomized trial
PubMed ID: 31300705
Higherāprotein infant formula produced higher plasma Ī±āKG and altered BCAAācatabolism markers years laterāevidence that Ī±āKG tracks protein/aminoāacid balance.
Exercise recovery (5)
- Nutritional and clinical efficacy of ornithine alpha-ketoglutarate in severe burn patients
PubMed ID: 10601539
Severe burn doubleāblind trial: better nitrogen retention, higher visceral proteins and less weight lossāsupports recovery from catabolic injury.
- Effects of Co-Ingestion of Ī²-Hydroxy-Ī²-Methylbutyrate and L-Arginine Ī±-Ketoglutarate on Jump Performance in Young Track and Field Athletes
PubMed ID: 33805883
Coāsupplement AAKG (as part of LāarginineāĪ±āKG) + HMB prevented declines in jump performance during intensive campāsupports preservation of function (AAKG present but confounded by HMB).
- Glutamine and alpha-ketoglutarate prevent the decrease in muscle free glutamine concentration and influence protein synthesis after total hip replacement
PubMed ID: 7666798
Perioperative AKG prevented the postoperative fall in muscle glutamine and total ribosomesāpreserves proteināsynthesis capacity relevant to recovery.
- Ornithine alpha-ketoglutarate improves wound healing in severe burn patients: a prospective randomized double-blind trial versus isonitrogenous controls
PubMed ID: 10890617
Burn trial with markedly shorter healing time and reduced catabolismāsupports improved recovery processes.
- A randomized controlled trial of the influence of the mode of enteral ornithine alpha-ketoglutarate administration in burn patients
PubMed ID: 9482764
Burn RCT: enteral OKG improved nitrogen balance, reduced muscle catabolism and accelerated wound healingāstrong recovery signal.
Skin repair (4)
- Efficacy and safety of ornithine alpha-ketoglutarate in heel pressure ulcers in elderly patients: results of a randomized controlled trial
PubMed ID: 19621198
Multicenter RCT in elderly: ornithineāAKG modestly accelerated early closure of heel pressure ulcers in the ā¤8 cmĀ² subgroup.
- A randomized controlled trial of the influence of the mode of enteral ornithine alpha-ketoglutarate administration in burn patients
PubMed ID: 9482764
Burn patients: bolus OKG sped wound healing and improved nitrogen balanceārobust randomized evidence.
- Nutritional and clinical efficacy of ornithine alpha-ketoglutarate in severe burn patients
PubMed ID: 10601539
Severe burn trial improved nitrogen retention and visceral proteinsāsupports faster tissue repair and wound recovery.
- Ornithine alpha-ketoglutarate improves wound healing in severe burn patients: a prospective randomized double-blind trial versus isonitrogenous controls
PubMed ID: 10890617
Severe burn RCT: OKG shortened wound healing time substantially (60 vs 90 d) and reduced catabolismāstrong clinical evidence.
Stress resilience (3)
- A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects
PubMed ID: 7976777
Elderly recovery RCT: improved appetite, weight gain and independence indicate increased clinical resilience.
- A randomized controlled trial of the influence of the mode of enteral ornithine alpha-ketoglutarate administration in burn patients
PubMed ID: 9482764
Burn RCT: improved nitrogen balance and faster wound healingāenhanced physiologic resilience to severe injury.
- Nutritional and clinical efficacy of ornithine alpha-ketoglutarate in severe burn patients
PubMed ID: 10601539
Severe burn trial with better protein retention and less weight lossāsupports improved resilience in catabolic stress.
Skin health (2)
- A randomized controlled trial of the influence of the mode of enteral ornithine alpha-ketoglutarate administration in burn patients
PubMed ID: 9482764
Bolus OKG in burn patients reduced healing timeāstrong evidence for improved skin/tissue recovery.
- Ornithine alpha-ketoglutarate improves wound healing in severe burn patients: a prospective randomized double-blind trial versus isonitrogenous controls
PubMed ID: 10890617
Severe burn trial: substantial acceleration of wound healingādirectly relevant to skin repair.
Detoxification (2)
- Antioxidant Activity with Increased Endogenous Levels of Vitamin C, E and A Following Dietary Supplementation with a Combination of Glutathione and Resveratrol Precursors
PubMed ID: 33105552
Ī±āKG included in glutathioneāprecursor regimen markedly raised erythrocyte GSH and related antioxidant markersādirect detoxification relevance.
- Metabolomics strategy comprehensively unveils the effect of catechins intervention on the biomarkers of exposure to acrylamide and biomarkers of cardiometabolic risk
PubMed ID: 36191485
Tea catechin supplementation increased urinary excretion of acrylamide mercapturic metabolites and regulated 2āoxoglutarateāevidence for enhanced detox/excretion pathways.
Endurance (2)
- The impact of preoperative micronutrient supplementation in lung surgery. A prospective randomized trial of oral supplementation of combined alpha-ketoglutaric acid and 5-hydroxymethylfurfural
PubMed ID: 17768058
AKG+5āHMF preop improved VO2max in lung surgery patientsāevidence of increased aerobic capacity (combined supplement).
- Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men
PubMed ID: 16928472
AAKG (arginine+AKG) in trained men increased 1RM and Wingate peak powerāimproved anaerobic performance (combination product).
Healthy aging (1)
- A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects
PubMed ID: 7976777
Elderly RCT: OKG improved appetite, weight and independenceāclinically relevant functional aging outcomes.
Bone health (1)
- Alpha-ketoglutarate decreases serum levels of C-terminal cross-linking telopeptide of type I collagen (CTX) in postmenopausal women with osteopenia: six-month study
PubMed ID: 17896582
Doubleāblind RCT in osteopenic women: AKGāCa produced a large (ā37%) reduction in CTX (resorption marker); plausible boneāprotective effect.
Energy & Fatigue (1)
- Myocardial Protecting Role of Glutamine in Patients with Low Ejection Fraction Undergoing Elective On-Pump Coronary Artery Bypass Graft Surgery
PubMed ID: 35411147
Perioperative glutamine increased myocardial Ī±āKG tissue levels and improved lactate/CI/troponināstrong mechanistic evidence for cellular metabolic support (indirect for AKG supplement).
Similar by evidence
Supplements the same benefits carry qualifying findings for ā a fact about the evidence graph, not a recommendation to swap.
Products with Alpha-Ketoglutarate
Search all93 products whose verified label declares Alpha-Ketoglutarate ā not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet ā this is what the field is asking, not what it found.