Alanylglutamine
12 benefits mapped to clinical evidence across supplements.
Dose per serving from research
6 study groups in 4 studies say how much Alanylglutamine participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 10 g to 25 g, 50% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 2.5 g to 5 g | 1 |
| 5 g to 10 g | 1 |
| 10 g to 25 g | 3 |
| 25 g to 50 g | 1 |
Benefit Evidence
Research sources
Stress resilience (23)
- Impact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage
PubMed ID: 18200673
Large reductions in complications, infections and mortality in severe pancreatitis — rapid and meaningful recovery benefit.
- The influence of parenteral glutamine supplementation on glucose homeostasis in critically ill polytrauma patients--A randomized-controlled clinical study
PubMed ID: 24931756
Lower incidence of hyperglycemia and decreased insulin requirements in trauma patients indicate blunted stress hyperglycemia.
- Intravenous alanyl-L-glutamine balances glucose-insulin homeostasis and facilitates recovery in patients undergoing colonic resection: a randomised controlled trial
PubMed ID: 24374803
Perioperative Ala‑Gln improved metabolic/inflammatory responses and shortened recovery markers (flatus, LOS).
- Glutamine is cardioprotective in patients with ischemic heart disease following cardiopulmonary bypass
PubMed ID: 22167767
Reduced troponin and improved cardiac output after bypass suggest protection against surgical stress.
- Randomized clinical trial of gut-specific nutrients in critically ill surgical patients
PubMed ID: 20629109
Faster return of gut function and fewer sepsis events in a gut-nutrient cocktail including glutamine implies quicker postoperative recovery.
- [Effect of glutamine on serum interleukin-8 and tumor necrosis factor-alpha levels in patients with severe pancreatitis]
PubMed ID: 18227044
In severe pancreatitis Ala‑Gln reduced inflammatory cytokines and was associated with fewer deaths and shorter hospital stays.
- The role of parenteral glutamine supplement for surgical patient perioperatively: result of a single center, prospective and controlled study
PubMed ID: 18712409
Modest attenuation of postoperative inflammation and slightly shorter (non‑significant) hospital stay.
- Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infections in critically ill surgical patients
PubMed ID: 18596310
Reduced ventilation days and infections in SICU subgroup indicating faster recovery.
- L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis
PubMed ID: 18596311
Reduced infectious morbidity and improved N balance in severe pancreatitis—better handling of critical stress.
- Efficacy of Perioperative Infusion of N(2)-L-alanyl-L-glutamine in Glycemic Control for Patients With Uncontrolled Diabetes Mellitus Presented for Urgent Coronary Artery Bypass Surgery: A Randomized Controlled Trial
PubMed ID: 37537132
In diabetics undergoing urgent CABG, Ala‑Gln reduced intra/postoperative glucose and insulin needs, aiding stress management.
- [Effect of early enriched parenteral alanyl-glutamine on heat shock protein 70 (HSP70) expression in critical patients]
PubMed ID: 17708846
Increased HSP70 (stress protein) and fewer reported organ dysfunctions suggest stress resilience.
- Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients
PubMed ID: 16424718
Preservation of insulin sensitivity during trauma indicates better handling of metabolic stress.
- Effects of perioperative parenteral glutamine-dipeptide supplementation on plasma endotoxin level, plasma endotoxin inactivation capacity and clinical outcome
PubMed ID: 16054522
Perioperative trial improved endotoxin inactivation and sCD14 with slight shortening of hospital stay — modest faster recovery evidence.
- [The effects of glutamine dipeptide on the improvement of endotoxemia in severely burned patients]
PubMed ID: 12641984
Burn trial with shorter hospital stay and improved wound healing — demonstrates faster recovery after injury.
- Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients
PubMed ID: 12352037
Improved 6-month survival in longer-treated ICU patients and plasma GLN restoration suggest better recovery.
- Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study
PubMed ID: 11104589
Shorter hospital stay and improved N balance in postop patients receiving Ala‑Gln.
- [The influence of alanyl-glutamine on immunologic functions and morbidity in postoperative total parenteral nutrition. Preliminary results of a prospective randomized trial]
PubMed ID: 10327575
Faster immune recovery and fewer complications after esophageal/stomach surgery.
- The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients
PubMed ID: 10483898
Improved physiologic markers and shorter stay after surgical stress with PN supplemented with Ala‑Gln.
- L-alanin-L-glutamine supplementation improves the outcome after colorectal surgery for cancer
PubMed ID: 17573745
Colorectal surgery RCT showed fewer infectious complications and shorter hospital stay — strong perioperative recovery benefit.
- L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study
PubMed ID: 16505644
Large ICU RCT with fewer complications and infections and improved glycaemia — clearly accelerated recovery in critically ill patients.
- [Effect of alanyl-glutamine in postoperative total parenteral nutrition on postoperative immunosuppression and morbidity. Preliminary results of a prospective randomized study]
PubMed ID: 9931687
Faster monocyte HLA-DR recovery and fewer postop complications indicate speeded recovery from surgical stress.
- Effects of Ala-Gln dipeptide parenteral nutrition on rehabilitation and infection of liver transplantation patients
PubMed ID: 40996178
After liver transplant Ala‑Gln shortened ICU/hospital stays and reduced infections—meaningful recovery benefits.
- A randomized double-blind controlled proof-of-concept study of alanyl-glutamine for reduction of post-myomectomy adhesions
PubMed ID: 37023559
Marked reduction in adhesions after surgery facilitates faster postoperative recovery.
Immune support (21)
- Depletion of plasma antioxidants in surgical intensive care unit patients requiring parenteral feeding: effects of parenteral nutrition with or without alanyl-glutamine dipeptide supplementation
PubMed ID: 18065204
Raised GSH, vitamin C and zinc in surgical patients could augment antioxidant/immune defenses.
- [Effect of glutamine on serum interleukin-8 and tumor necrosis factor-alpha levels in patients with severe pancreatitis]
PubMed ID: 18227044
In severe pancreatitis IV Ala‑Gln lowered inflammatory cytokines and was associated with fewer deaths and shorter stays.
- Clinical trial: prophylactic intravenous alanyl-glutamine reduces the severity of gastrointestinal toxicity induced by chemotherapy--a randomized crossover study
PubMed ID: 19549287
Lowered endotoxin and reduced GI toxicity during chemo with Ala‑Gln — supports host defence and immune resilience.
- Randomized clinical trial of glutamine-supplemented versus standard parenteral nutrition in infants with surgical gastrointestinal disease
PubMed ID: 22513659
Surgical infants had lower sepsis risk while on TPN with Ala‑Gln (HR 0.33) — protective immunologic effect during TPN.
- EFFECTS OF STANDARD AND/OR GLUTAMINE DIPEPTIDE AND/OR OMEGA-3 FATTY ASCID-SUPPLEMENTED PARENTERAL NUTRITION ON NEUTROPHIL FUNCTIONS, INTERLEUKIN-8 LEVEL AND LENGTH OF STAY--A DOUBLE BLIND,CONTROLLED, RANDOMISED STUDY
PubMed ID: 26866103
Increased neutrophil phagocytosis in malnourished colorectal cancer patients given GLN (±omega-3).
- A randomized controlled trial of alanyl-glutamine supplementation in peritoneal dialysis fluid to assess impact on biomarkers of peritoneal health
PubMed ID: 30360960
Eight‑week PD Ala‑Gln improved ex‑vivo cytokine responses and reduced systemic inflammation; clinical peritonitis events fewer during Ala‑Gln.
- Effects of Ala-Gln dipeptide parenteral nutrition on rehabilitation and infection of liver transplantation patients
PubMed ID: 40996178
Post‑liver transplant Ala‑Gln reduced infections and improved nutritional/inflammatory markers.
- L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis
PubMed ID: 18596311
Improved immune markers, positive nitrogen balance and fewer infections in severe pancreatitis.
- Perioperative GLY-GLN infusion diminishes the surgery-induced period of immunosuppression: accelerated restoration of the lipopolysaccharide-stimulated tumor necrosis factor-alpha response
PubMed ID: 12496537
Perioperative Gly‑Gln accelerated recovery of LPS‑stimulated TNF‑α production — indicates restoration of immune responsiveness.
- L-alanyl-L-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis
PubMed ID: 14757388
TPN Ala‑Gln after secondary peritonitis reduced infectious morbidity and improved immune/nitrogen markers — clear immune effect.
- L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study
PubMed ID: 16505644
Large multicenter ICU RCT showed reduced infections (overall and pneumonia) with Ala‑Gln in TPN — strong immune resilience evidence.
- L-alanin-L-glutamine supplementation improves the outcome after colorectal surgery for cancer
PubMed ID: 17573745
Perioperative Ala‑Gln around colorectal surgery reduced wound infections/abscesses and LOS — clinical immune benefit.
- The effect of L-alanyl-L-glutamine dipeptide supplemented total parenteral nutrition on infectious morbidity and insulin sensitivity in critically ill patients
PubMed ID: 21336131
Multicenter ICU trial reduced nosocomial infections and improved glycaemic/insulin metrics — supports immune benefit.
- [The influence of alanyl-glutamine on immunologic functions and morbidity in postoperative total parenteral nutrition. Preliminary results of a prospective randomized trial]
PubMed ID: 10327575
Faster HLA-DR recovery and fewer complications after esophageal/stomach surgery.
- Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients
PubMed ID: 12352037
Raised plasma GLN and improved 6-month survival in longer-treated ICU patients — systemic immune relevance.
- The effect of glutamine-supplemented total parenteral nutrition on nitrogen economy depends on severity of diseases in surgical patients
PubMed ID: 12127929
Increased certain T-lymphocyte/CD4 counts and improved nitrogen balance in less severe patients.
- [The prospective study on application of parenteral nutrition with alanyl-glutamine dipeptide in chemotherapy of gastrointestinal neoplasms patients]
PubMed ID: 16965691
GI cancer patients on chemo had attenuated immune declines and fewer side effects with Ala‑Gln — immune supportive.
- Wasting and intestinal barrier function in children taking alanyl-glutamine-supplemented enteral formula
PubMed ID: 17325559
Children had improved barrier and growth which indirectly supports immune fitness in enterally supplemented group.
- Impact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage
PubMed ID: 18200673
Severe pancreatitis trial: large reductions in infections and mortality with early AG.
- Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infections in critically ill surgical patients
PubMed ID: 18596310
Reduced nosocomial infections and increased plasma glutamine in surgical ICU subgroup.
- [Effect of alanyl-glutamine in postoperative total parenteral nutrition on postoperative immunosuppression and morbidity. Preliminary results of a prospective randomized study]
PubMed ID: 9931687
Faster monocyte HLA-DR recovery and fewer postoperative complications in TPN surgical patients.
Illness recovery (21)
- The influence of parenteral glutamine supplementation on glucose homeostasis in critically ill polytrauma patients--A randomized-controlled clinical study
PubMed ID: 24931756
Reduced hyperglycemia and insulin needs in trauma patients likely contribute to improved clinical recovery.
- A randomized controlled trial of alanyl-glutamine supplementation in peritoneal dialysis fluid to assess impact on biomarkers of peritoneal health
PubMed ID: 30360960
Improved peritoneal membrane health, immune responsiveness and lowered systemic inflammation over 8 weeks.
- Intervention and Mechanisms of Alanyl-glutamine for Inflammation, Nutrition, and Enteropathy: A Randomized Controlled Trial
PubMed ID: 32826717
Transient improvements in gut barrier and short‑term weight gain in undernourished children support recovery potential.
- A randomized double-blind controlled proof-of-concept study of alanyl-glutamine for reduction of post-myomectomy adhesions
PubMed ID: 37023559
Substantial reduction in postoperative adhesions yields clear clinical recovery benefit.
- Effects of Ala-Gln dipeptide parenteral nutrition on rehabilitation and infection of liver transplantation patients
PubMed ID: 40996178
Post‑liver transplant Ala‑Gln improved nutrition markers, shortened ICU/hospital stays and reduced infections.
- L-alanyl-L-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis
PubMed ID: 14757388
Fewer infections and improved protein/nitrogen markers after peritonitis indicate better overall postoperative recovery.
- [Effect of alanyl-glutamine in postoperative total parenteral nutrition on postoperative immunosuppression and morbidity. Preliminary results of a prospective randomized study]
PubMed ID: 9931687
Faster immune recovery and fewer complications translating to clinical recovery benefits.
- L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study
PubMed ID: 16505644
Multicenter ICU RCT showed lower complicated outcome and infection rates and better glucose control — substantial overall recovery improvement.
- The effect of L-alanyl-L-glutamine dipeptide supplemented total parenteral nutrition on infectious morbidity and insulin sensitivity in critically ill patients
PubMed ID: 21336131
Reduced nosocomial infections and modest improvements in glycaemia and insulin usage indicate better overall outcomes in ICU patients.
- L-alanin-L-glutamine supplementation improves the outcome after colorectal surgery for cancer
PubMed ID: 17573745
Large randomized colorectal surgery trial showed fewer infections, less wound dehiscence/abscess and shorter LOS — strong overall recovery benefit.
- The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients
PubMed ID: 10483898
Improved barrier function, nitrogen balance and shorter hospital stay in a large trial indicate overall recovery promotion.
- [The influence of alanyl-glutamine on immunologic functions and morbidity in postoperative total parenteral nutrition. Preliminary results of a prospective randomized trial]
PubMed ID: 10327575
Improved immune markers and fewer postop complications support overall recovery.
- Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study
PubMed ID: 11104589
Improved nitrogen balance, normalized plasma GLN and shorter stay denote improved overall recovery.
- Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients
PubMed ID: 12352037
Increased plasma GLN and better 6-month survival in long-treated ICU patients signify durable recovery benefit.
- [The effects of glutamine dipeptide on the improvement of endotoxemia in severely burned patients]
PubMed ID: 12641984
Burn RCT showed faster wound healing, lower endotoxin and shorter hospital stay — clear overall recovery advantages.
- Impact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage
PubMed ID: 18200673
Large, clinically meaningful reductions in mortality, infections and hospital stay in severe pancreatitis.
- L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis
PubMed ID: 18596311
Improved immune markers, positive N balance and fewer infections in severe pancreatitis trial.
- Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infections in critically ill surgical patients
PubMed ID: 18596310
Reduced infections and ventilator days in SICU subgroup, plus plasma GLN rise, reflect better recovery.
- [Effect of glutamine on serum interleukin-8 and tumor necrosis factor-alpha levels in patients with severe pancreatitis]
PubMed ID: 18227044
Pancreatitis trial showed lower inflammatory cytokines, fewer deaths and shorter stays—strong global recovery signal.
- Nutrition support with glutamine dipeptide in patients undergoing liver transplantation
PubMed ID: 20005375
Liver transplant patients receiving Ala‑Gln had better nutritional indices, less hepatic injury markers and shorter hospital stay — supports overall recovery.
- Intravenous alanyl-L-glutamine balances glucose-insulin homeostasis and facilitates recovery in patients undergoing colonic resection: a randomised controlled trial
PubMed ID: 24374803
Faster return of bowel function, improved glucose/insulin handling and reduced inflammation after colon surgery.
Gut health (13)
- The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients
PubMed ID: 10483898
Large RCT with reduced lactulose/mannitol ratio indicating strengthened intestinal barrier.
- [Impact of glutamine of gut permeability and clinical prognosis on the aging patients undergoing gastric-intestinal operation]
PubMed ID: 12903420
Improved L/M ratio reported in elderly GI surgery patients.
- [The effects of glutamine dipeptide on the improvement of endotoxemia in severely burned patients]
PubMed ID: 12641984
Oral Ala‑Gln in burns lowered endotoxin and improved wound healing/hospital stay — endotoxin reduction implies better gut barrier/health.
- Effects of perioperative parenteral glutamine-dipeptide supplementation on plasma endotoxin level, plasma endotoxin inactivation capacity and clinical outcome
PubMed ID: 16054522
Perioperative Ala‑Gln improved endotoxin‑inactivation capacity (EIC) and sCD14 — supports barrier/host defence.
- Wasting and intestinal barrier function in children taking alanyl-glutamine-supplemented enteral formula
PubMed ID: 17325559
Large pediatric RCT: improved gut barrier tests and weight gain over 4 months after enteral AG.
- Impact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage
PubMed ID: 18200673
Severe pancreatitis: marked clinical benefit including fewer infections and shorter stay—consistent with improved gut-related outcomes.
- Clinical trial: prophylactic intravenous alanyl-glutamine reduces the severity of gastrointestinal toxicity induced by chemotherapy--a randomized crossover study
PubMed ID: 19549287
Prophylactic IV Ala‑Gln during chemo raised plasma Gln, lowered endotoxin and reduced GI toxicity symptoms — strong gut benefit.
- Randomized clinical trial of gut-specific nutrients in critically ill surgical patients
PubMed ID: 20629109
Multi‑nutrient gut cocktail including glutamine sped bowel recovery and reduced sepsis — plausible contribution from glutamine (indirect).
- Improvement of intestinal permeability with alanyl-glutamine in HIV patients: a randomized, double blinded, placebo-controlled clinical trial
PubMed ID: 23657308
Improved intestinal absorption (mannitol excretion) in HIV patients, especially after recent diarrhea.
- Intravenous alanyl-L-glutamine balances glucose-insulin homeostasis and facilitates recovery in patients undergoing colonic resection: a randomised controlled trial
PubMed ID: 24374803
Perioperative IV Ala‑Gln around colon surgery reduced inflammation and sped recovery—supports colonic/gut recovery.
- A randomized controlled trial of alanyl-glutamine supplementation in peritoneal dialysis fluid to assess impact on biomarkers of peritoneal health
PubMed ID: 30360960
Longer PD treatment improved CA‑125 appearance rate (marker of mesothelial cell mass/membrane integrity) and reduced peritoneal protein loss.
- Intervention and Mechanisms of Alanyl-glutamine for Inflammation, Nutrition, and Enteropathy: A Randomized Controlled Trial
PubMed ID: 32826717
Dose‑dependent transient improvement in lactulose (barrier) excretion demonstrating strengthened intestinal barrier at day 10.
- A randomized double-blind controlled proof-of-concept study of alanyl-glutamine for reduction of post-myomectomy adhesions
PubMed ID: 37023559
Single IP bolus markedly reduced postoperative adhesions after myomectomy, a clinically meaningful surgical gut outcome.
Tissue repair (11)
- Effects of Ala-Gln dipeptide parenteral nutrition on rehabilitation and infection of liver transplantation patients
PubMed ID: 40996178
Improved nutrition markers and fewer infections after transplant support tissue healing and repair.
- L-alanyl-L-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis
PubMed ID: 14757388
TPN Ala‑Gln after secondary peritonitis improved nitrogen balance and albumin/IgA — supports protein availability for repair.
- The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients
PubMed ID: 10483898
Improved nitrogen balance and reduced permeability that can facilitate tissue repair.
- L-alanin-L-glutamine supplementation improves the outcome after colorectal surgery for cancer
PubMed ID: 17573745
Perioperative Ala‑Gln reduced wound infections/abscesses and shortened LOS after colorectal surgery — supports tissue healing and complication reduction.
- Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study
PubMed ID: 11104589
Improved N balance and hospital recovery consistent with enhanced tissue reparative capacity.
- [The effects of glutamine dipeptide on the improvement of endotoxemia in severely burned patients]
PubMed ID: 12641984
Randomized burn trial showed improved wound healing rates and markedly shorter hospital stay with oral Ala‑Gln — strong tissue‑repair evidence.
- Impact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage
PubMed ID: 18200673
Fewer complications, infections and lower mortality in severe pancreatitis—consistent with improved organ/tissue recovery.
- [Effect of glutamine on serum interleukin-8 and tumor necrosis factor-alpha levels in patients with severe pancreatitis]
PubMed ID: 18227044
IV Ala‑Gln in severe pancreatitis lowered inflammatory cytokines and was associated with fewer deaths and shorter stays—supporting tissue recovery.
- A randomized controlled trial of alanyl-glutamine supplementation in peritoneal dialysis fluid to assess impact on biomarkers of peritoneal health
PubMed ID: 30360960
Improved peritoneal membrane health and reduced protein loss indicate better local tissue integrity/repair.
- [Clinical effect of alanyl-glutamine-enriched nutritional support in the treatment of children with abdominal Henoch-Schönlein purpura]
PubMed ID: 30782281
Reduced steroid use and less weight loss in pediatric abdominal vasculitis point to improved tissue/clinical recovery.
- A randomized double-blind controlled proof-of-concept study of alanyl-glutamine for reduction of post-myomectomy adhesions
PubMed ID: 37023559
Large, clinically meaningful reduction in postoperative adhesions indicates strong effect on healing/repair processes.
Metabolism (11)
- Nutrition support with glutamine dipeptide in patients undergoing liver transplantation
PubMed ID: 20005375
Improved nutritional indices and biochemical markers after liver transplant, indicating metabolic benefits.
- L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study
PubMed ID: 16505644
Multicenter ICU trial improved glycaemic control and reduced insulin requirements — clinically meaningful metabolic benefit.
- The effect of L-alanyl-L-glutamine dipeptide supplemented total parenteral nutrition on infectious morbidity and insulin sensitivity in critically ill patients
PubMed ID: 21336131
Reduced hyperglycaemia/insulin needs in ICU patients receiving Ala‑Gln — supports glucose homeostasis.
- Efficacy of Perioperative Infusion of N(2)-L-alanyl-L-glutamine in Glycemic Control for Patients With Uncontrolled Diabetes Mellitus Presented for Urgent Coronary Artery Bypass Surgery: A Randomized Controlled Trial
PubMed ID: 37537132
Preoperative infusion in diabetic CABG patients markedly reduced intra/postoperative glucose and insulin needs.
- The influence of parenteral glutamine supplementation on glucose homeostasis in critically ill polytrauma patients--A randomized-controlled clinical study
PubMed ID: 24931756
Parenteral Ala‑Gln in polytrauma reduced hyperglycemia incidence and lowered daily insulin requirements.
- Intravenous alanyl-L-glutamine balances glucose-insulin homeostasis and facilitates recovery in patients undergoing colonic resection: a randomised controlled trial
PubMed ID: 24374803
Perioperative IV Ala‑Gln improved insulin sensitivity/attenuated peak glucose and lowered FFA/TNF‑α.
- L-alanyl-glutamine pretreatment attenuates acute inflammatory response in children submitted to palatoplasty
PubMed ID: 21971662
Blunted postoperative glucose rise in children given Ala‑Gln, consistent with metabolic modulation.
- Glutamine is cardioprotective in patients with ischemic heart disease following cardiopulmonary bypass
PubMed ID: 22167767
Post‑bypass trial showed improved cardiac hemodynamics and lower troponin with Ala‑Gln — supports metabolic/organ stability.
- Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study
PubMed ID: 11104589
Improved nitrogen balance and normalized plasma glutamine—supports metabolic nitrogen homeostasis.
- Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients
PubMed ID: 16424718
Multiple‑trauma RCT preserved/improved insulin‑mediated glucose disposal (euglycaemic clamp) — robust metabolic effect.
- Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients
PubMed ID: 12352037
Raised plasma glutamine and improved 6-month survival in long-treated ICU patients (systemic metabolic relevance).
Muscle growth (11)
- The effect of glutamine-supplemented total parenteral nutrition on nitrogen economy depends on severity of diseases in surgical patients
PubMed ID: 12127929
Improved cumulative nitrogen balance in lower-severity subgroup.
- L-alanyl-L-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis
PubMed ID: 14757388
Improved nitrogen balance and albumin/IgA with Ala‑Gln in secondary peritonitis — supports protein utilization.
- Effect of the route of nutrition and L-alanyl-L-glutamine supplementation in amino acids' concentration in trauma patients
PubMed ID: 28980034
Supplementation raised plasma glutamine/alanine, consistent with available substrate for protein metabolism.
- The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients
PubMed ID: 10483898
Cumulative N balance improved significantly in a large randomized trial.
- Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study
PubMed ID: 11104589
Improved N balance and normalized plasma GLN on AG — strong support for protein use.
- [The effects of glutamine dipeptide on the improvement of endotoxemia in severely burned patients]
PubMed ID: 12641984
Oral Ala‑Gln in burns increased plasma Gln and improved wound healing — consistent with improved protein support.
- [The prospective study on application of parenteral nutrition with alanyl-glutamine dipeptide in chemotherapy of gastrointestinal neoplasms patients]
PubMed ID: 16965691
Attenuation of albumin/prealbumin decline and better nitrogen balance during chemo indicate protein-sparing effect.
- L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis
PubMed ID: 18596311
Positive nitrogen balance achieved in severe pancreatitis with AG.
- Frequent intravenous pulses of growth hormone together with glutamine supplementation in prolonged critical illness after multiple trauma: effects on nitrogen balance, insulin resistance, and substrate oxidation
PubMed ID: 18496372
GH+AG markedly improved nitrogen balance (anabolic effect) despite insulin tradeoffs.
- Intravenous alanyl-L-glutamine balances glucose-insulin homeostasis and facilitates recovery in patients undergoing colonic resection: a randomised controlled trial
PubMed ID: 24374803
Improved insulin sensitivity may favor an anabolic milieu and protein utilization postoperatively.
- Effects of Ala-Gln dipeptide parenteral nutrition on rehabilitation and infection of liver transplantation patients
PubMed ID: 40996178
Improved nutrition markers during PN with Ala‑Gln suggest better protein/nitrogen status or utilization.
Body composition (10)
- Frequent intravenous pulses of growth hormone together with glutamine supplementation in prolonged critical illness after multiple trauma: effects on nitrogen balance, insulin resistance, and substrate oxidation
PubMed ID: 18496372
GH+AG produced clear anabolic (nitrogen-sparing) effects supporting lean tissue retention.
- [Clinical effect of alanyl-glutamine-enriched nutritional support in the treatment of children with abdominal Henoch-Schönlein purpura]
PubMed ID: 30782281
In children with abdominal HSP, Ala‑Gln reduced inpatient weight loss, indicating preservation of nutritional/lean mass.
- Intervention and Mechanisms of Alanyl-glutamine for Inflammation, Nutrition, and Enteropathy: A Randomized Controlled Trial
PubMed ID: 32826717
Short‑term weight gains in undernourished children suggest preservation/restoration of body mass (not specifically lean mass).
- Effects of Ala-Gln dipeptide parenteral nutrition on rehabilitation and infection of liver transplantation patients
PubMed ID: 40996178
Post‑liver transplant Ala‑Gln improved nutrition markers (prealbumin/albumin/transferrin) and shortened ICU/hospital stay, implying preserved nutritional status.
- The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients
PubMed ID: 10483898
Improved cumulative nitrogen balance in a large RCT of PN patients.
- Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study
PubMed ID: 11104589
Improved nitrogen balance and normalized plasma GLN with shorter hospital stay — favors lean mass preservation.
- L-alanyl-L-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis
PubMed ID: 14757388
TPN Ala‑Gln improved nitrogen balance and protein/immune blood markers after peritonitis — supports preservation of lean mass.
- The effect of glutamine-supplemented total parenteral nutrition on nitrogen economy depends on severity of diseases in surgical patients
PubMed ID: 12127929
Nitrogen balance benefit and immune cell increases in less severe patients indicate preserved protein/lean mass.
- [The effects of glutamine dipeptide on the improvement of endotoxemia in severely burned patients]
PubMed ID: 12641984
Burn patients on oral Ala‑Gln had improved wound healing and shorter stay and higher plasma Gln — nitrogen sparing effects plausible.
- [The prospective study on application of parenteral nutrition with alanyl-glutamine dipeptide in chemotherapy of gastrointestinal neoplasms patients]
PubMed ID: 16965691
Chemotherapy patients experienced attenuated declines in albumin/prealbumin and better nitrogen balance with Ala‑Gln — supports lean mass preservation.
Digestive support (8)
- [The effects of glutamine dipeptide on the improvement of endotoxemia in severely burned patients]
PubMed ID: 12641984
Oral Ala‑Gln in burns lowered endotoxin and accelerated wound healing — supports mucosal/epithelial repair mechanisms indirectly.
- Wasting and intestinal barrier function in children taking alanyl-glutamine-supplemented enteral formula
PubMed ID: 17325559
Children had improved barrier function and subsequent growth, implying mucosal recovery.
- Clinical trial: prophylactic intravenous alanyl-glutamine reduces the severity of gastrointestinal toxicity induced by chemotherapy--a randomized crossover study
PubMed ID: 19549287
Prophylactic Ala‑Gln during chemotherapy lowered endotoxin and decreased nausea/vomiting and diarrhoea scores — direct symptom relief.
- A randomized double-blind controlled proof-of-concept study of alanyl-glutamine for reduction of post-myomectomy adhesions
PubMed ID: 37023559
Single intraperitoneal bolus markedly reduced formation/severity of postoperative adhesions after myomectomy.
- Intervention and Mechanisms of Alanyl-glutamine for Inflammation, Nutrition, and Enteropathy: A Randomized Controlled Trial
PubMed ID: 32826717
Improved intestinal permeability and short‑term weight gain in undernourished children indicate mucosal recovery potential.
- The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients
PubMed ID: 10483898
Improved permeability and nitrogen balance consistent with intestinal recovery on PN.
- Improvement of intestinal permeability with alanyl-glutamine in HIV patients: a randomized, double blinded, placebo-controlled clinical trial
PubMed ID: 23657308
Improved absorption in HIV patients, particularly those with recent diarrhea, may alleviate digestive symptoms.
- Standardized parenteral alanyl-glutamine dipeptide supplementation is not beneficial in autologous transplant patients: a randomized, double-blind, placebo controlled study
PubMed ID: 12476290
Reduced days with diarrhea in autologous transplant patients (but offset by worse mucositis and outcomes).
Nutrient uptake (5)
- [Impact of glutamine of gut permeability and clinical prognosis on the aging patients undergoing gastric-intestinal operation]
PubMed ID: 12903420
Reported lower L/M ratio in elderly GI surgery patients implying improved absorption.
- Wasting and intestinal barrier function in children taking alanyl-glutamine-supplemented enteral formula
PubMed ID: 17325559
Improved lactulose urinary excretion and weight gain in children — better absorption and growth.
- Improvement of intestinal permeability with alanyl-glutamine in HIV patients: a randomized, double blinded, placebo-controlled clinical trial
PubMed ID: 23657308
Randomized double‑blind trial showed increased urinary mannitol excretion indicating improved small‑bowel absorption.
- Intervention and Mechanisms of Alanyl-glutamine for Inflammation, Nutrition, and Enteropathy: A Randomized Controlled Trial
PubMed ID: 32826717
Improved intestinal permeability in undernourished children and short‑term weight gain imply better nutrient uptake.
- The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients
PubMed ID: 10483898
Improved gut permeability (L/M ratio) which correlates with absorptive function.
Energy & Fatigue (5)
- Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients
PubMed ID: 12352037
Restored plasma GLN in ICU patients which is a substrate for cellular energetics in stressed states.
- Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients
PubMed ID: 16424718
Preservation of insulin‑mediated glucose disposal in trauma patients implies better cellular energy utilization.
- Impact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage
PubMed ID: 18200673
Marked clinical improvement in severe pancreatitis including reduced complications and shortened stay — may reduce illness-related fatigue.
- The effect of intravenous alanyl-glutamine supplementation on plasma glutathione levels in intensive care unit trauma patients receiving enteral nutrition: the results of a randomized controlled trial
PubMed ID: 19608826
IV Ala‑Gln raised plasma glutathione (~19–23% increases) in critically injured patients — supports cellular redox/energy homeostasis strongly.
- Intravenous alanyl-L-glutamine balances glucose-insulin homeostasis and facilitates recovery in patients undergoing colonic resection: a randomised controlled trial
PubMed ID: 24374803
Reduced inflammation and improved insulin sensitivity perioperatively can favor cellular energy metabolism.
Appetite regulation (1)
- [Clinical effect of alanyl-glutamine-enriched nutritional support in the treatment of children with abdominal Henoch-Schönlein purpura]
PubMed ID: 30782281
Reduced inpatient weight loss in children with abdominal HSP suggests improved ability to maintain nutrition/appetite during illness.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Alanylglutamine
Search all10 products whose verified label declares Alanylglutamine — not every bottle that mentions it in a title.