Beta-Glucans
18 benefits mapped to clinical evidence across supplements.
Dose per serving from products
88 products in our catalogue print how much Beta-Glucans a serving holds.
Most common: 250 mg to 500 mg, 36% of 88 products.
| Dose per serving | Products |
|---|---|
| 10 mg or less | 4 |
| 10 mg to 25 mg | 2 |
| 25 mg to 50 mg | 6 |
| 50 mg to 100 mg | 13 |
| 100 mg to 250 mg | 29 |
| 250 mg to 500 mg | 32 |
| over 500 mg | 2 |
Dose per serving from research
145 study groups in 81 studies say how much Beta-Glucans participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 g to 5 g, 51% of 145 study groups.
| Daily dose | Study groups |
|---|---|
| 50 mg or less | 8 |
| 50 mg to 100 mg | 1 |
| 100 mg to 250 mg | 14 |
| 250 mg to 500 mg | 3 |
| 500 mg to 1 g | 6 |
| 1 g to 2.5 g | 10 |
| 2.5 g to 5 g | 74 |
| 5 g to 10 g | 15 |
| 10 g to 25 g | 7 |
| over 25 g | 7 |
Commonly used together
29 of 145 study groups took Beta-Glucans with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Fiber | 12 |
| Zinc | 4 |
| Phytosterols | 3 |
Benefit Evidence
Lipid lowering: LDL/TC ↓
Glucose lowering: GI/AUC ↓
Inflammation/barrier: IL-6/TAG ↓
Stress: ↓cortisol, -1.8 cm waist
Stress: mood/energy ↑
Stress: inflammation ↓
Satiety +19% intake↓
Hunger/fullness improved
Energy intake −18%
Gut bacteria shift: Enterobacter↓
SCFA rise, inflammation↓
LDL/cholesterol↓, glucose↓
Better mood/energy (+19%)
Symptom relief, modest mood
Survival, appetite, sleep
Lipid lowering: LDL/TC ↓
Glucose lowering: GI/AUC ↓
Inflammation/barrier: IL-6/TAG ↓
Stress: ↓cortisol, -1.8 cm waist
Stress: mood/energy ↑
Stress: inflammation ↓
Gut bacteria shift: Enterobacter↓
SCFA rise, inflammation↓
LDL/cholesterol↓, glucose↓
Research sources
Immune support (37)
- Effects after inhalation of (1-->3)-beta-D-glucan and relation to mould exposure in the home
PubMed ID: 12137243
Inhaled beta‑glucan altered LPS/TNF‑α and IL‑10 responses and lymphocyte counts in humans, especially mold‑exposed subjects — supports immune modulation.
- Clinical outcome of postoperative adjuvant immunochemotherapy with sizofiran for patients with resectable gastric cancer: a randomised controlled study
PubMed ID: 1835619
Fungal β‑glucan (sizofiran) added to chemotherapy improved long‑term outcomes in a curatively resected gastric cancer subgroup, consistent with immunomodulatory effects.
- Clinical effect of sizofiran combined with irradiation in cervical cancer patients: a randomized controlled study. Cooperative Study Group on SPG for Gynecological Cancer
PubMed ID: 1573785
Sizofiran added to radiotherapy increased complete response rates and sped lymphocyte recovery — strong clinical immunomodulatory signal.
- Infection prevention in patients with severe multiple trauma with the immunomodulator beta 1-3 polyglucose (glucan)
PubMed ID: 8211583
Randomized trial in severely injured patients showed large reductions in pneumonia, sepsis and infection‑related deaths with glucan — strong clinical immune benefit.
- Improvement of long-term prognosis in patients with ovarian cancers by adjuvant sizofiran immunotherapy: a prospective randomized controlled study
PubMed ID: 8507540
Sizofiran appeared to improve long‑term prognosis when added to chemotherapy in ovarian cancer — likely immune‑mediated adjunct benefit.
- A phase II multicenter, double-blind, randomized, placebo-controlled study of three dosages of an immunomodulator (PGG-glucan) in high-risk surgical patients
PubMed ID: 7979954
PGG‑glucan phase II showed dose‑response trend toward fewer serious infections — suggestive immune protection.
- Randomized phase I/II trial of a macrophage-specific immunomodulator (PGG-glucan) in high-risk surgical patients
PubMed ID: 7979607
Preoperative PGG‑glucan reduced postoperative infections, antibiotic use and ICU stay in high‑risk surgical patients.
- Activated (HLA-DR+) T-lymphocyte subsets in cervical carcinoma and effects of radiotherapy and immunotherapy with sizofiran on cell-mediated immunity and survival
PubMed ID: 7705677
Sizofiran added to radiotherapy improved 5‑year survival and accelerated activated T‑cell recovery — clinically meaningful immune benefit.
- A phase II controlled study of a combination of the immune modulator, lentinan, with didanosine (ddI) in HIV patients with CD4 cells of 200-500/mm3
PubMed ID: 8721897
Lentinan + ddI raised CD4 counts in HIV patients over many weeks — clear immunologic effect in RCT setting.
- [Immune modulatory and therapeutic effect of lentinan on condyloma acuminatum]
PubMed ID: 11477860
Lentinan adjunct improved immune markers and reduced wart recurrence (clinical immune outcome).
- [Effects of lentinan of peripheral blood mononuclear cell expression of interleukin-2 receptor in patients with chronic hepatitis B in vivo and in vitro]
PubMed ID: 10681809
Lentinan increased PBMC IL‑2 receptor expression in chronic hepatitis B (in vivo/in vitro) — robust immune marker changes.
- Effect of PGG-glucan on the rate of serious postoperative infection or death observed after high-risk gastrointestinal operations. Betafectin Gastrointestinal Study Group
PubMed ID: 10487593
Large perioperative trial showed significant reductions in serious infection/death in prespecified high‑risk (noncolorectal/malnourished) subgroups.
- Influence of yeast-derived 1,3/1,6 glucopolysaccharide on circulating cytokines and chemokines with respect to upper respiratory tract infections
PubMed ID: 22465901
University student trial: trend to fewer URTI days and lower MCP‑1 during infection—supports immune resilience in a real‑world sample.
- Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise
PubMed ID: 23927572
Randomized trials showed baker's‑yeast β‑glucan halved URTI symptomatic days post‑marathon and preserved salivary IgA (mucosal immunity).
- Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body's defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects
PubMed ID: 23340963
Large RCT: oral yeast (1,3/1,6) β‑glucan reduced common cold incidence and severity — strong clinical immune benefit.
- Effect of beta glucan on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy: a randomized double-blind placebo-controlled clinical trial
PubMed ID: 25081694
Small randomized trial in chemo patients altered cytokines (↑IL‑12, altered IL‑4) and tended to blunt WBC drop — evidence of immunomodulation.
- Effect of β-glucan on drain fluid and amount of drainage following modified radical mastectomy
PubMed ID: 24421054
Oral β‑glucan after mastectomy lowered inflammatory cytokines in seroma, indicating anti‑inflammatory/immunomodulatory effects aiding immune‑related recovery.
- Yeast β-Glucan Modulates Inflammation and Waist Circumference in Overweight and Obese Subjects
PubMed ID: 27715351
6‑week oral yeast β‑glucan increased anti‑inflammatory IL‑10 and lowered proinflammatory cytokines in overweight subjects — supports immune modulation.
- Effect of Immune-Enhancing Enteral Nutrition Enriched with or without Beta-Glucan on Immunomodulation in Critically Ill Patients
PubMed ID: 27271657
ICU immune‑nutrition with mushroom β‑glucan increased NK activity and improved inflammatory/nutritional markers — strong immunomodulatory signal.
- Yeast-derived β-1,3/1,6 glucan, upper respiratory tract infection and innate immunity in older adults
PubMed ID: 28606567
Older adults: yeast β‑glucan increased ex vivo IFN‑γ responses and trended to fewer symptomatic URTI days — immunomodulatory evidence.
- Effect of ß-glucan on serum levels of IL-12, hs-CRP, and clinical outcomes in multiple-trauma patients: a prospective randomized study
PubMed ID: 30028484
Critically ill trauma patients on enteral β‑glucan showed higher IL‑12 and less organ dysfunction/shorter ventilation — meaningful immune/clinical effects.
- Soluble and Insoluble Yeast β-Glucan Differentially Affect Upper Respiratory Tract Infection in Marathon Runners: A Double-Blind, Randomized Placebo-Controlled Trial
PubMed ID: 31573387
Marathon trial (insoluble yeast β‑glucan): fewer URTI days and lower severity — supports immune‑protective effect in stressed athletes.
- Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 31816842
Endurance‑trained adults: Euglena fermentate rich in β‑1,3‑glucan reduced sick days and URTI symptoms — clinical immune benefit in athletes.
- Effect and Tolerability of a Nutritional Supplement Based on a Synergistic Combination of β-Glucans and Selenium- and Zinc-Enriched Saccharomyces cerevisiae (ABB C1(®)) in Volunteers Receiving the Influenza or the COVID-19 Vaccine: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 34959898
Yeast β‑glucan + selenium/zinc raised micronutrients and augmented vaccine‑related immune markers—supports immune adjunctive effects.
- β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency-A Randomized, Placebo-Controlled, and Double-Blinded Trial
PubMed ID: 33963479
12‑week β‑glucan trial reduced URTI symptoms and improved a 'protective qi' score and self‑reported health—consistent with immune benefit.
- Effect of Oral β-Glucan on Antibody Response to Ganglioside Vaccine in Patients With High-Risk Neuroblastoma: A Phase 2 Randomized Clinical Trial
PubMed ID: 36547975
Oral β‑glucan raised anti‑GD2 IgG1 titers during vaccine priming (modest, genetics-dependent immunologic enhancement).
- Yeast Beta-Glucan Enhances Antibody Response Following Influenza Vaccination - A Double-Blind, Randomized, Placebo-Controlled Pilot Trial
PubMed ID: 40746014
Yeast β‑glucan modestly increased seasonal influenza antibody responses in older adults (pilot RCT).
- Novel Chewable Pleuran-Based Supplement Decreases Respiratory Tract Infections in Children: A Randomised Controlled Trial
PubMed ID: 41085920
Pleuran chewables reduced respiratory infections in children vs placebo, consistent with clinically meaningful immune benefit.
- Effects of Chronic Barley Consumption on Upper Respiratory Tract Symptoms in Japanese Healthy Adults: A Randomized, Parallel-Group, Controlled Trial
PubMed ID: 39064742
Daily cooked waxy barley increased NK activity in low‑baseline subjects and reduced some URT symptom days—evidence of immunomodulation.
- Alleviation of seasonal allergic symptoms with superfine beta-1,3-glucan: a randomized study
PubMed ID: 17379290
Double-blind RCT in allergic patients: orally absorbable beta-1,3-glucan reduced allergic symptoms and blunted IgE rises — clear immune modulation.
- Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC
PubMed ID: 18670743
Lentinan (beta-glucan) given with local cancer therapies associated with greater tumour necrosis and longer survival — consistent with immune-adjuvant activity (combination therapy).
- Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes
PubMed ID: 21249381
Pleuran RCT in athletes: reduced URTI symptoms and supported NK cells and phagocytosis—strong direct immune support evidence.
- [Clinical observation of thermotherapy combined with thoracic injection of lentinan in treatment of cancerous hydrothorax of patients with lung cancer]
PubMed ID: 21910335
Lentinan plus thermotherapy in lung cancer patients improved cellular immunity markers—indicative of immune modulation though combined therapy.
- Supplementation with a soluble β-glucan exported from Shiitake medicinal mushroom, Lentinus edodes (Berk.) singer mycelium: a crossover, placebo-controlled study in healthy elderly
PubMed ID: 22164761
Oral lentinan in elderly increased circulating B‑cell numbers—supportive immunologic change in older adults.
- Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections
PubMed ID: 23261366
Pediatric RCT: pleuran reduced recurrent respiratory infections and modulated immune markers—robust clinical immune benefit.
- Baker's yeast β-glucan supplementation increases monocytes and cytokines post-exercise: implications for infection risk?
PubMed ID: 22575076
Baker's‑yeast β‑glucan increased monocytes and LPS‑stimulated cytokine responses after exercise—clear innate immune activation in humans.
- Baker's yeast beta-glucan supplement reduces upper respiratory symptoms and improves mood state in stressed women
PubMed ID: 23378458
Wellmune trial in stressed women: reduced cold/flu incidence—clinical immune protection with symptomatic and biomarker improvement.
Metabolism (35)
- Effect of 6 weeks' consumption of β-glucan-rich oat products on cholesterol levels in mildly hypercholesterolaemic overweight adults
PubMed ID: 21810288
6‑week oat β‑glucan trial lowered total and LDL cholesterol in overweight adults; responder heterogeneity limits certainty.
- Changes in serum lipids and postprandial glucose and insulin concentrations after consumption of beverages with beta-glucans from oats or barley: a randomised dose-controlled trial
PubMed ID: 16015250
5 g oat β‑glucan beverage lowered total cholesterol by 7.4% and early postprandial glucose/insulin — source/dose dependent metabolic effect.
- Effect of high beta-glucan barley on serum cholesterol concentrations and visceral fat area in Japanese men--a randomized, double-blinded, placebo-controlled trial
PubMed ID: 18074229
12‑week high‑β‑glucan barley intervention lowered LDL/total cholesterol and visceral fat — clinically relevant metabolic benefit.
- The effects of concentrated barley beta-glucan on blood lipids in a population of hypercholesterolaemic men and women
PubMed ID: 17445284
Large RCT: 5 g/day β‑glucan substantially lowered LDL and total cholesterol (strong metabolic effect).
- Physiological effects of concentrated barley beta-glucan in mildly hypercholesterolemic adults
PubMed ID: 18838533
Moderate RCT: small changes in cholesterol ratio and weight depending on molecular weight.
- High-Molecular-Weight β-Glucan Decreases Serum Cholesterol Differentially Based on the CYP7A1 rs3808607 Polymorphism in Mildly Hypercholesterolemic Adults
PubMed ID: 26936139
3 g/day HMW barley β‑glucan slightly lowered total cholesterol versus control.
- Effects of high β-glucan barley on visceral fat obesity in Japanese individuals: A randomized, double-blind study
PubMed ID: 28870472
12‑week replacement of rice with high β‑glucan barley reduced visceral fat and body weight (metabolic improvements).
- Barley β-glucan reduces blood cholesterol levels via interrupting bile acid metabolism
PubMed ID: 29115200
HMW β‑glucan lowered total cholesterol and increased bile acid synthesis — mechanism for lipid lowering.
- Alterations in gut microbiota composition and metabolic parameters after dietary intervention with barley beta glucans in patients with high risk for metabolic syndrome development
PubMed ID: 30396006
4‑week barley bread modestly lowered plasma cholesterol and increased propionate (metabolic markers).
- Effect of Barley on Postprandial Blood Glucose Response and Appetite in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39599684
Strong randomized crossover evidence of substantial and significant postprandial glucose and insulin reductions with barley fibre drink.
- The hypocholesterolemic effects of beta-glucan in oatmeal and oat bran. A dose-controlled study
PubMed ID: 2005733
Strong randomized dose‑response evidence that oat β‑glucan substantially lowers LDL cholesterol in hyperlipidemic adults.
- A controlled study on the effect of beta-glucan-rich oat bran on serum lipids in hypercholesterolemic subjects: relation to apolipoprotein E phenotype
PubMed ID: 1334101
Oat bran supplying ~10.3 g/day produced small short‑term LDL/TC reductions at 4 weeks that faded by 8 weeks (transient effect).
- Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial
PubMed ID: 11976156
Soluble fiber (beta‑glucan/psyllium) produced small but significant lipid improvements and lowered estimated CVD risk (human RCT).
- Food products containing free tall oil-based phytosterols and oat beta-glucan lower serum total and LDL cholesterol in hypercholesterolemic adults
PubMed ID: 12612157
Beta‑glucan + phytosterols lowered LDL and total cholesterol in a well‑powered human trial (combination product; effect partly attributable to beta‑glucan).
- Cholesterol-lowering effect of beta-glucan from oat bran in mildly hypercholesterolemic subjects may decrease when beta-glucan is incorporated into bread and cookies
PubMed ID: 12885701
Beta‑glucan lowered LDL when delivered in a beverage but not in bread/cookies — food matrix affects metabolic efficacy.
- Cholesterol-lowering benefits of oat-containing cereal in Hispanic americans
PubMed ID: 15942550
Large RCT: oat cereal with beta‑glucan produced modest but significant LDL and total cholesterol reductions — metabolic cardio benefit.
- Effect of an oat bran-rich supplement on the metabolic profile of overweight premenopausal women
PubMed ID: 15942159
Human RCT in overweight women: oat‑bran muffins raised HDL and improved total/HDL ratio — favorable metabolic change.
- Beta-glucan incorporated into a fruit drink effectively lowers serum LDL-cholesterol concentrations
PubMed ID: 16522906
Fruit drink containing oat beta‑glucan lowered total and LDL cholesterol and altered sterol markers indicating reduced absorption — solid metabolic evidence.
- Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure
PubMed ID: 17151592
Randomized double‑blind trial: beta‑glucan foods improved insulin responses and lowered BP in obese subgroup — strong clinical metabolic signals.
- Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial
PubMed ID: 17386092
6 g/day concentrated oat beta-glucan for 6 weeks produced modest but significant reductions in total and LDL cholesterol in adults at CVD risk.
- Muesli with 4 g oat beta-glucans lowers glucose and insulin responses after a bread meal in healthy subjects
PubMed ID: 17426742
Acute study: 4 g oat beta-glucan in muesli significantly lowered postprandial glucose and insulin in healthy volunteers — supports glycemic/metabolic balance.
- Simultaneous intake of beta-glucan and plant stanol esters affects lipid metabolism in slightly hypercholesterolemic subjects
PubMed ID: 17311944
5 g/day oat beta-glucan lowered LDL ~5% and combined with plant stanols produced larger LDL reductions; mechanistic bile-acid/absorption changes reported.
- The consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes
PubMed ID: 19230737
3 g/day beta-glucan via enriched bread significantly lowered LDL and total cholesterol and improved insulin resistance in type 2 diabetics (clinically meaningful effects).
- Physicochemical properties of oat β-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial
PubMed ID: 20660224
Large randomized trial: 3 g/day high‑MW oat β‑glucan lowered LDL by ~5%—clear metabolic/cardio benefit.
- Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians
PubMed ID: 22118569
Multicenter trial: 3–4 g/day oat β‑glucan lowered LDL (4.8–10.3%) across ethnic groups—consistent metabolic effect.
- Oat prevents obesity and abdominal fat distribution, and improves liver function in humans
PubMed ID: 23371785
12‑week daily oat (β‑glucan) cereal lowered weight, body fat and ALT in overweight adults — direct metabolic improvements.
- Yeast β-Glucan Modulates Inflammation and Waist Circumference in Overweight and Obese Subjects
PubMed ID: 27715351
6‑week oral yeast β‑glucan reduced waist circumference and blood pressure and improved inflammatory profile — meaningful metabolic effects.
- Effects of oat β-glucan consumption at breakfast on ad libitum eating, appetite, glycemia, insulinemia and GLP-1 concentrations in healthy subjects
PubMed ID: 29920323
Acute 4 g oat β‑glucan lowered early postprandial glucose and insulin — supports metabolic balance.
- Effect of adding oat bran to instant oatmeal on glycaemic response in humans - a study to establish the minimum effective dose of oat β-glucan
PubMed ID: 29480316
Dose‑dependent reductions in postprandial iAUC and peak with small amounts of oat β‑glucan — robust glycemic data.
- High molecular weight oat β-glucan enhances lipid-lowering effects of phytosterols. A randomised controlled trial
PubMed ID: 30792143
3 g oat β‑glucan + phytosterols produced additive LDL lowering — metabolic risk factor improvement.
- A randomized Placebo-Controlled Clinical Trial to Evaluate the Medium-Term Effects of Oat Fibers on Human Health: The Beta-Glucan Effects on Lipid Profile, Glycemia and inTestinal Health (BELT) Study
PubMed ID: 32138344
3 g/day oat β‑glucan for 8 weeks produced large, clinically meaningful LDL and TC reductions — strong metabolic effect.
- An Oat β-Glucan Beverage Reduces LDL Cholesterol and Cardiovascular Disease Risk in Men and Women with Borderline High Cholesterol: A Double-Blind, Randomized, Controlled Clinical Trial
PubMed ID: 34236436
3 g/day high‑MW oat β‑glucan lowered LDL and estimated CVD risk in borderline‑high adults—clinically important metabolic effect.
- Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial
PubMed ID: 34375514
Shiitake bars lowered triglycerides (~10%) and improved antioxidant markers—beneficial metabolic lipid effects.
- Postprandial Glycemic and Insulinemic Response by a Brewer's Spent Grain Extract-Based Food Supplement in Subjects with Slightly Impaired Glucose Tolerance: A Monocentric, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 36235569
Brewer's‑spent‑grain fiber reduced postprandial insulin iAUC ~20% and sped glucose return—solid acute metabolic improvement.
- Efficacy of Food Industry By-Product β-Glucan/Chitin-Chitosan on Lipid Profile of Overweight and Obese Individuals: Sustainability and Nutraceuticals
PubMed ID: 39408385
Yeast‑derived β‑glucan/chitin–chitosan copolymer raised HDL and lowered ApoB in overweight/obese adults over 12 weeks (consistent lipid improvements).
Stress resilience (18)
- Effect of ß-glucan on serum levels of IL-12, hs-CRP, and clinical outcomes in multiple-trauma patients: a prospective randomized study
PubMed ID: 30028484
Enteral β‑glucan in trauma patients improved organ dysfunction and shortened ventilation — supports broader physiological resilience.
- Effect of PGG-glucan on the rate of serious postoperative infection or death observed after high-risk gastrointestinal operations. Betafectin Gastrointestinal Study Group
PubMed ID: 10487593
Perioperative PGG‑glucan reduced serious infection/death in high‑risk subgroups — subgroup evidence for enhanced resilience.
- Effects after inhalation of (1-->3)-beta-D-glucan and relation to mould exposure in the home
PubMed ID: 12137243
Immune shifts in mold‑exposed subjects suggest enhanced defensive capacity in challenged individuals.
- Alleviation of seasonal allergic symptoms with superfine beta-1,3-glucan: a randomized study
PubMed ID: 17379290
Lowered allergic symptom burden and IgE modulation could contribute to greater everyday resilience in allergic individuals.
- The consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes
PubMed ID: 19230737
Metabolic improvements in diabetics (LDL, insulin resistance) support physiological resilience to cardiometabolic stressors.
- Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes
PubMed ID: 21249381
Athlete study showing fewer URTI symptoms and maintained phagocytosis/NK cells supports resilience during training stress.
- Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections
PubMed ID: 23261366
Fewer respiratory infections and immune marker changes in children indicate improved overall resilience to pathogens.
- Baker's yeast beta-glucan supplement reduces upper respiratory symptoms and improves mood state in stressed women
PubMed ID: 23378458
Supplement reduced URS and improved mood/energy in moderately stressed women—evidence for resilience under stress.
- Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise
PubMed ID: 23927572
Fewer URTI symptomatic days and maintained mucosal IgA after heavy exertion indicate enhanced resilience to infection/stress.
- Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body's defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects
PubMed ID: 23340963
Reduced incidence/severity of common colds implies improved day‑to‑day resilience to respiratory infections.
- Effect of β-glucan on drain fluid and amount of drainage following modified radical mastectomy
PubMed ID: 24421054
Faster postoperative recovery and lower local inflammation reflect improved physiological resilience after surgery.
- Yeast β-Glucan Modulates Inflammation and Waist Circumference in Overweight and Obese Subjects
PubMed ID: 27715351
Metabolic and anti‑inflammatory improvements in overweight subjects support broader resilience to cardiometabolic stressors.
- A phase II multicenter, double-blind, randomized, placebo-controlled study of three dosages of an immunomodulator (PGG-glucan) in high-risk surgical patients
PubMed ID: 7979954
Phase II dose‑response trend toward fewer serious infections indicates potential resilience benefit at higher doses.
- Infection prevention in patients with severe multiple trauma with the immunomodulator beta 1-3 polyglucose (glucan)
PubMed ID: 8211583
Large reductions in infections and infection‑related death in severely injured patients indicate major increase in physiologic resilience.
- Clinical effect of sizofiran combined with irradiation in cervical cancer patients: a randomized controlled study. Cooperative Study Group on SPG for Gynecological Cancer
PubMed ID: 1573785
Improved tumor response rates and faster lymphocyte recovery indicate increased physiologic resilience with sizofiran adjunct therapy.
- Clinical outcome of postoperative adjuvant immunochemotherapy with sizofiran for patients with resectable gastric cancer: a randomised controlled study
PubMed ID: 1835619
Sizofiran improved long‑term outcomes in a cancer subgroup — suggests enhanced host resilience in that clinical context.
- Novel nutraceutical supplements with yeast β-glucan, prebiotics, minerals, and Silybum marianum (silymarin) ameliorate obesity-related metabolic and clinical parameters: A double-blind randomized trial
PubMed ID: 36778595
Supplement (multi‑ingredient including yeast β‑glucan) reduced cortisol over 180 days — biochemical marker of lower physiological stress.
- Randomized phase I/II trial of a macrophage-specific immunomodulator (PGG-glucan) in high-risk surgical patients
PubMed ID: 7979607
Preoperative PGG‑glucan reduced infectious complications, IV antibiotics and ICU time — supports improved resilience to surgical stress.
Respiratory comfort (17)
- Influence of yeast-derived 1,3/1,6 glucopolysaccharide on circulating cytokines and chemokines with respect to upper respiratory tract infections
PubMed ID: 22465901
Student trial reported improved 'breathe easily' scores and trend to fewer URTI days—modest respiratory comfort evidence.
- Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections
PubMed ID: 23261366
Children on pleuran had fewer respiratory infections and improved related outcomes—strong clinical respiratory benefit.
- Efficacy of a new medical device based on colloidal silver and carbossimetyl beta glucan in treatment of upper airways disease in children
PubMed ID: 21946445
Nasal device containing carboxymethyl β‑glucan plus colloidal silver improved symptom scores and recovery in children with viral rhinitis—combined product, but respiratory benefit observed.
- Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes
PubMed ID: 21249381
Pleuran reduced URTI symptoms in athletes—supports respiratory comfort.
- Alleviation of seasonal allergic symptoms with superfine beta-1,3-glucan: a randomized study
PubMed ID: 17379290
Oral superfine beta-1,3-glucan reduced seasonal/perennial allergic respiratory symptoms (rhinorrhea, congestion, sneezing, itchy/watery eyes) in RCT.
- Effects after inhalation of (1-->3)-beta-D-glucan and relation to mould exposure in the home
PubMed ID: 12137243
Inhaled beta‑glucan altered immune markers and increased lymphocytes, with clearer effects in mold‑exposed participants — supports respiratory immune effects.
- Infection prevention in patients with severe multiple trauma with the immunomodulator beta 1-3 polyglucose (glucan)
PubMed ID: 8211583
Marked reduction in pneumonia incidence in severely injured patients on glucan therapy — important respiratory benefit in that setting.
- Effects of Chronic Barley Consumption on Upper Respiratory Tract Symptoms in Japanese Healthy Adults: A Randomized, Parallel-Group, Controlled Trial
PubMed ID: 39064742
Daily cooked waxy barley reduced cumulative days of sneezing and tiredness (URT symptom days) — direct respiratory/URT symptom benefit.
- Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial
PubMed ID: 30380356
Post‑marathon dairy beverage with dispersible yeast β‑glucan reduced URTI symptom severity and missed workouts.
- Resveratrol plus carboxymethyl-β-glucan in children with recurrent respiratory infections: a preliminary and real-life experience
PubMed ID: 25416925
Nasal spray containing resveratrol + carboxymethyl‑β‑glucan reduced days with nasal obstruction and rhinorrhea in children with recurrent respiratory infections (confounded product).
- Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body's defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects
PubMed ID: 23340963
Oral yeast β‑glucan reduced incidence and severity of common cold episodes in adults in a multicentre RCT.
- Effects of Yeast (1,3)-(1,6)-Beta-Glucan on Severity of Upper Respiratory Tract Infections: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Subjects
PubMed ID: 30198828
Healthy adults: lower early URTI severity with yeast β‑glucan — symptomatic respiratory improvement.
- Novel Chewable Pleuran-Based Supplement Decreases Respiratory Tract Infections in Children: A Randomised Controlled Trial
PubMed ID: 41085920
Chewable pleuran supplement (with vitamin D/zinc) reduced total respiratory tract infections in children over 3 months (randomized DB trial).
- Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma
PubMed ID: 40021713
Large multicenter RCT: oral pleuran (mushroom β‑glucan) improved asthma control and reduced RTIs/exacerbations in children (clinically relevant respiratory benefit).
- Effects of Nasal Solution Incorporating Resveratrol and Carboxymethyl-Β-Glucan in Preschool Non-Atopic Children with Wheezing
PubMed ID: 39064639
Intermittent nasal resveratrol + carboxymethyl‑β‑glucan at URTI onset markedly reduced wheezing and steroid/hospitalization days in preschool children (large clinical effect, combination product limits attribution).
- Soluble and Insoluble Yeast β-Glucan Differentially Affect Upper Respiratory Tract Infection in Marathon Runners: A Double-Blind, Randomized Placebo-Controlled Trial
PubMed ID: 31573387
Marathon RCT: insoluble yeast β‑glucan reduced number and severity of post‑race cold/flu symptoms — strong respiratory symptom benefit.
- Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise
PubMed ID: 23927572
Baker's‑yeast β‑glucan reduced URTI symptomatic days and preserved salivary IgA after marathon — strong respiratory/mucosal benefit.
Healthy aging (16)
- The hypocholesterolemic effects of beta-glucan in oatmeal and oat bran. A dose-controlled study
PubMed ID: 2005733
Large randomized study showing dose‑dependent LDL reductions with oat β‑glucan — supports cardiovascular risk reduction relevant to healthy aging.
- [Effect of lentinan for advanced prostate carcinoma]
PubMed ID: 8128920
Lentinan added to chemo prolonged survival in metastatic prostate cancer — clinically relevant to longevity in disease contexts.
- Activated (HLA-DR+) T-lymphocyte subsets in cervical carcinoma and effects of radiotherapy and immunotherapy with sizofiran on cell-mediated immunity and survival
PubMed ID: 7705677
Sizofiran improved 5‑year survival in cervical cancer when added to radiotherapy — supports improved long‑term outcomes in serious disease.
- Food products containing free tall oil-based phytosterols and oat beta-glucan lower serum total and LDL cholesterol in hypercholesterolemic adults
PubMed ID: 12612157
Products with beta‑glucan + phytosterols reduced LDL and total cholesterol in adults — supports long‑term cardiovascular risk reduction (combination product).
- Cholesterol-lowering benefits of oat-containing cereal in Hispanic americans
PubMed ID: 15942550
Large human trial: oat cereal with beta‑glucan produced modest but significant reductions in total and LDL cholesterol — relevant to long‑term cardiovascular health.
- Effect of an oat bran-rich supplement on the metabolic profile of overweight premenopausal women
PubMed ID: 15942159
Overweight women on oat‑bran muffins raised HDL and improved cholesterol ratio — favorable lipid profile change relevant to healthy aging.
- Beta-glucan incorporated into a fruit drink effectively lowers serum LDL-cholesterol concentrations
PubMed ID: 16522906
Randomized human trial: fruit drink with oat beta‑glucan lowered total and LDL cholesterol and altered sterol markers — supports cardiometabolic aging benefits.
- The effects of concentrated barley beta-glucan on blood lipids in a population of hypercholesterolaemic men and women
PubMed ID: 17445284
5 g/day β‑glucan produced substantial LDL and total cholesterol reductions (cardiometabolic aging relevance).
- Impact of β-glucan on the Fecal Water Genotoxicity of Polypectomized Patients
PubMed ID: 27043932
Three months β‑glucan bread reduced fecal‑water genotoxicity (potential cancer‑risk/aging relevance in polypectomy patients).
- Physicochemical properties of oat β-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial
PubMed ID: 20660224
Large RCT: 3 g/day oat β‑glucan lowered LDL by ~4–6%—cardiometabolic LDL lowering is relevant to healthy aging.
- Yeast β-Glucan Modulates Inflammation and Waist Circumference in Overweight and Obese Subjects
PubMed ID: 27715351
Yeast β‑glucan reduced waist circumference, lowered BP and shifted cytokines favorably in overweight subjects — supports cardiometabolic healthy‑aging factors.
- Oral Intake of Carboxymethyl-Glucan (CM-G) from Yeast (Saccharomyces uvarum) Reduces Malondialdehyde Levels in Healthy Men
PubMed ID: 26287149
Carboxymethyl‑β‑glucan reduced MDA (lipid peroxidation), an antioxidant effect relevant to ageing mechanisms.
- Oat prevents obesity and abdominal fat distribution, and improves liver function in humans
PubMed ID: 23371785
12‑week oat β‑glucan cereal lowered weight, body fat and ALT — metabolic/liver benefits relevant to long‑term health.
- Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians
PubMed ID: 22118569
Large multicenter trial: 3–4 g/day bioactive oat β‑glucan lowered LDL (~5–10%)—supports cardiovascular risk reduction with aging relevance.
- Effect of high beta-glucan barley on serum cholesterol concentrations and visceral fat area in Japanese men--a randomized, double-blinded, placebo-controlled trial
PubMed ID: 18074229
12‑week replacement of rice with high‑β‑glucan barley lowered LDL, total cholesterol and visceral fat — clinically meaningful for aging health.
- Effects of high β-glucan barley on visceral fat obesity in Japanese individuals: A randomized, double-blind study
PubMed ID: 28870472
12‑week replacement reduced visceral fat and body weight, benefits for long‑term cardiometabolic aging risk.
Illness recovery (14)
- Effect of β-glucan on drain fluid and amount of drainage following modified radical mastectomy
PubMed ID: 24421054
Large RCT after mastectomy: oral β‑glucan reduced drain volume and shortened time to drain removal — clear faster postoperative recovery signal.
- Clinical outcome of postoperative adjuvant immunochemotherapy with sizofiran for patients with resectable gastric cancer: a randomised controlled study
PubMed ID: 1835619
Adjuvant sizofiran improved long‑term outcomes in a cancer subgroup; suggests better recovery/recurrence control in that context.
- Yeast Beta-Glucan Supplementation Downregulates Markers of Systemic Inflammation after Heated Treadmill Exercise
PubMed ID: 32325856
Recreational exercisers: yeast β‑glucan reduced post‑exercise inflammatory chemokines and accelerated myoglobin recovery — supports faster muscle recovery.
- Effect of ß-glucan on serum levels of IL-12, hs-CRP, and clinical outcomes in multiple-trauma patients: a prospective randomized study
PubMed ID: 30028484
Trauma ICU patients: enteral β‑glucan associated with shorter mechanical ventilation and improved SOFA — clinical faster recovery signal.
- Clinical effect of sizofiran combined with irradiation in cervical cancer patients: a randomized controlled study. Cooperative Study Group on SPG for Gynecological Cancer
PubMed ID: 1573785
Sizofiran accelerated lymphocyte recovery after radiotherapy and raised tumor complete response rates—direct signal for faster immune recovery in a clinical setting.
- Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise
PubMed ID: 23927572
Reduced post‑marathon URTI days and preserved salivary IgA suggest improved post‑exercise recovery of mucosal defenses.
- The beneficial effects of Kampo medicine Dai-ken-chu-to after hepatic resection: a prospective randomized control study
PubMed ID: 23435143
Kampo (DKT) shortened time to first flatus/bowel movement and reduced inflammation after liver surgery—supports faster GI recovery (note: includes BDG biomarker change).
- Influence of mesh type on the quality of early outcomes after inguinal hernia repair in ambulatory setting controlled study: Glucamesh® vs Polypropylene®
PubMed ID: 21061131
β‑D‑glucan coated mesh reduced early post‑op pain and shortened hospital stay after hernia repair—strong evidence for faster short‑term recovery.
- Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes
PubMed ID: 21249381
Pleuran reduced URTI incidence in athletes which can translate to reduced downtime and faster return to activity.
- [Combination of early nasojejunal feeding with modern synbiotic therapy in the treatment of severe acute pancreatitis (prospective, randomized, double-blind study)]
PubMed ID: 16167471
Synbiotic (includes beta‑glucan) with early feeding reduced late organ dysfunction in severe pancreatitis — clinical signal for improved recovery (component confounding).
- Effect of PGG-glucan on the rate of serious postoperative infection or death observed after high-risk gastrointestinal operations. Betafectin Gastrointestinal Study Group
PubMed ID: 10487593
Perioperative PGG‑glucan reduced serious infections/death in high‑risk subgroups — subgroup evidence for improved postoperative recovery.
- Randomized phase I/II trial of a macrophage-specific immunomodulator (PGG-glucan) in high-risk surgical patients
PubMed ID: 7979607
Preoperative PGG‑glucan markedly reduced infections, IV antibiotic days and ICU length of stay — consistent with faster clinical recovery.
- A phase II multicenter, double-blind, randomized, placebo-controlled study of three dosages of an immunomodulator (PGG-glucan) in high-risk surgical patients
PubMed ID: 7979954
Dose‑response trend to fewer serious infections with PGG‑glucan suggests potential for improved recovery, though not definitive.
- Infection prevention in patients with severe multiple trauma with the immunomodulator beta 1-3 polyglucose (glucan)
PubMed ID: 8211583
Glucan in severely injured patients reduced infections and infection‑related mortality — supports faster/resilient recovery from critical injury.
Wellbeing (13)
- Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise
PubMed ID: 23927572
Fewer URTI symptomatic days and preserved mucosal IgA after heavy exercise support wellbeing in active individuals.
- Baker's yeast beta-glucan supplement reduces upper respiratory symptoms and improves mood state in stressed women
PubMed ID: 23378458
Wellmune trial reported better global mood and vigor alongside fewer URS—meaningful overall wellbeing benefit.
- The consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes
PubMed ID: 19230737
Cholesterol and insulin-resistance improvements in diabetics could meaningfully affect daily wellbeing.
- Alleviation of seasonal allergic symptoms with superfine beta-1,3-glucan: a randomized study
PubMed ID: 17379290
Clinically meaningful allergy symptom relief and IgE modulation likely improves perceived wellbeing in allergic patients.
- Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome
PubMed ID: 28724171
IBD patients reported improved general well‑being with a β‑glucan/inositol/enzyme supplement.
- Effect of beta-glucan, inositol and digestive enzymes in GI symptoms of patients with IBS
PubMed ID: 21796867
IBS patients reported symptomatic relief (bloating, gas, pain) and improved wellbeing with a β‑glucan‑containing product.
- Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial
PubMed ID: 17386092
LDL and total cholesterol reductions in at-risk adults support cardiometabolic wellbeing.
- Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure
PubMed ID: 17151592
Improved postprandial insulin responses and subgroup BP reductions may enhance overall wellbeing for obese individuals (human RCT).
- Infection prevention in patients with severe multiple trauma with the immunomodulator beta 1-3 polyglucose (glucan)
PubMed ID: 8211583
Substantial reductions in severe infections and infection‑related mortality would markedly improve clinical wellbeing in critical patients.
- Effect of Oat β-Glucan on Affective and Physical Feeling States in Healthy Adults: Evidence for Reduced Headache, Fatigue, Anxiety and Limb/Joint Pains
PubMed ID: 34062937
Daily oat β‑glucan reduced headache/fatigue in healthy adults—translates into better day‑to‑day wellbeing.
- A Quality-of-Life Study in Healthy Adults Supplemented with Lentinex® Beta-Glucan of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes)
PubMed ID: 32749096
Small RCT of oral lentinan showed improved self‑reported wellbeing over 4 weeks—direct evidence for overall wellbeing.
- Yeast β-Glucan Modulates Inflammation and Waist Circumference in Overweight and Obese Subjects
PubMed ID: 27715351
Improvements in waist circumference, BP and inflammatory markers point to better day‑to‑day health/wellbeing.
- Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body's defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects
PubMed ID: 23340963
Reduced cold incidence and symptom severity likely improves overall wellbeing during cold seasons.
Appetite suppression (10)
- Effects of oat β-glucan consumption at breakfast on ad libitum eating, appetite, glycemia, insulinemia and GLP-1 concentrations in healthy subjects
PubMed ID: 29920323
4 g high‑MW oat β‑glucan increased perceived fullness and reduced early postprandial glucose/insulin — clear short‑term satiety effect.
- Regular Consumption of Lipigo(®) Promotes the Reduction of Body Weight and Improves the Rebound Effect of Obese People Undergo a Comprehensive Weight Loss Program
PubMed ID: 32630079
Yeast‑derived β‑glucan supplement combined with diet/exercise helped weight loss and reduced regain—consistent with appetite/weight control effects.
- Adherence and impact of an oral nutritional supplement enriched in leucine, EVOO, EPA and DHA, and beta-glucans on the coverage of energy and protein requirements in patients with cancer and malnutrition: Alisenoc study
PubMed ID: 38341907
Oral nutritional supplements that contained beta‑glucans increased daily energy and protein intake in malnourished cancer patients (direct improvement in intake/adherence).
- Acute effect of oatmeal on subjective measures of appetite and satiety compared to a ready-to-eat breakfast cereal: a randomized crossover trial
PubMed ID: 24024772
Well‑powered crossover: oatmeal (higher β‑glucan) significantly increased fullness and reduced hunger AUC across the morning.
- The role of meal viscosity and oat β-glucan characteristics in human appetite control: a randomized crossover trial
PubMed ID: 24884934
Instant oatmeal (higher‑MW/viscous β‑glucan) increased fullness and reduced desire to eat/prospective intake vs ready‑to‑eat cereal.
- Enrichment of biscuits and juice with oat β-glucan enhances postprandial satiety
PubMed ID: 24434584
Adding 8 g oat β‑glucan to foods increased postprandial satiety in women; dose/matrix‑dependent effect.
- Instant Oatmeal Increases Satiety and Reduces Energy Intake Compared to a Ready-to-Eat Oat-Based Breakfast Cereal: A Randomized Crossover Trial
PubMed ID: 26273900
Instant oatmeal with higher‑viscosity β‑glucan increased satiety and reduced subsequent meal intake (~85 kcal) in crossover trial.
- Influence of whole grain barley, whole grain wheat, and refined rice-based foods on short-term satiety and energy intake
PubMed ID: 19643157
Whole‑grain barley reduced subjective hunger before lunch (no reduction in measured intake).
- Effect of Barley on Postprandial Blood Glucose Response and Appetite in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39599684
Barley fibre drink produced robust, significant reductions in hunger and increases in satiety across multiple time points.
- Effects of beta-glucan extracted from Saccharomyces cerevisiae on growth performance, and immunological and somatotropic responses of pigs challenged with Escherichia coli lipopolysaccharide
PubMed ID: 16908640
Pig experiments showed increased feed intake (ADFI) with beta‑glucan in some periods — clear effect on appetite in animals (direction may be increased appetite).
Gut health (9)
- Barley β-glucan increases fecal bile acid excretion and short chain fatty acid levels in mildly hypercholesterolemic individuals
PubMed ID: 29872803
HMW β‑glucan increased total fecal SCFA and lithocholic acid excretion (microbial fermentation evidence).
- [Combination of early nasojejunal feeding with modern synbiotic therapy in the treatment of severe acute pancreatitis (prospective, randomized, double-blind study)]
PubMed ID: 16167471
Synbiotic trial (probiotics + prebiotics including beta‑glucan) impacted outcomes in severe pancreatitis — suggests microbiome‑related benefits though beta‑glucan attribution is confounded.
- Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial
PubMed ID: 17386092
Study reported that concentrated oat beta-glucan was fermentable to SCFAs in vitro — direct link to colonic microbial fermentation.
- Glucose- and Lipid-Related Biomarkers Are Affected in Healthy Obese or Hyperglycemic Adults Consuming a Whole-Grain Pasta Enriched in Prebiotics and Probiotics: A 12-Week Randomized Controlled Trial
PubMed ID: 31162597
Synbiotic whole‑grain pasta with barley β‑glucans increased F. prausnitzii and improved inflammation/lipid markers in subgroups — direct microbiome effect in humans.
- Clinical Outcomes after Oat Beta-Glucans Dietary Treatment in Gastritis Patients
PubMed ID: 34444949
Oat β‑glucan increased fecal SCFAs and reduced gastric inflammatory infiltration—strong microbiome/fermentation signal.
- Modulation of human intestinal microbiota in a clinical trial by consumption of a β-D-glucan-enriched extract obtained from Lentinula edodes
PubMed ID: 33580297
Shiitake β‑D‑glucan altered colonic microbiota composition in a double‑blind trial—direct evidence for microbiome modulation.
- Nutraceutical blends predict enhanced health via microbiota reshaping improving cytokines and life quality: a Brazilian double-blind randomized trial
PubMed ID: 38750102
Randomized trial: nutraceutical (with β‑glucans) shifted gut microbiota (↑Bacteroides, ↓Firmicutes) and enriched SCFA‑producers—direct microbiome changes.
- Effect of Focused Ultrasound With or Without Anti-HPV β-Glucan Therapy on Persistent Cervical HPV Infection: A Randomized Controlled Trial
PubMed ID: 40916559
Topical β‑glucan dressing plus ultrasound restored healthy vaginal microbiota and increased lactobacilli relative to ultrasound alone (strong local microbiome effect).
- Alterations in gut microbiota composition and metabolic parameters after dietary intervention with barley beta glucans in patients with high risk for metabolic syndrome development
PubMed ID: 30396006
Barley bread raised propionate and altered gut microbiota composition (short‑term trial).
Vitality (7)
- The consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes
PubMed ID: 19230737
Improved lipid profile and insulin resistance in diabetics can translate to better daily energy and vitality.
- Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure
PubMed ID: 17151592
Improved insulin handling and subgroup BP reductions may translate to greater day‑to‑day vitality in affected individuals.
- Infection prevention in patients with severe multiple trauma with the immunomodulator beta 1-3 polyglucose (glucan)
PubMed ID: 8211583
Large infection reductions in trauma patients would substantially impact survivors' everyday health and vitality.
- Effect of Barley on Postprandial Blood Glucose Response and Appetite in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39599684
Acute satiety, fullness and reduced glucose/insulin peaks can translate into improved daily energy and vitality for many users.
- Baker's yeast beta-glucan supplement reduces upper respiratory symptoms and improves mood state in stressed women
PubMed ID: 23378458
Improvements in vigor and global mood with reduced URS support better everyday vitality in a stressed adult population.
- Effect of Oat β-Glucan on Affective and Physical Feeling States in Healthy Adults: Evidence for Reduced Headache, Fatigue, Anxiety and Limb/Joint Pains
PubMed ID: 34062937
Reported reductions in fatigue and headache in a 4‑month daily oat β‑glucan trial support improved daily vitality.
- Alleviation of seasonal allergic symptoms with superfine beta-1,3-glucan: a randomized study
PubMed ID: 17379290
Reduction in allergy symptoms likely improves day‑to‑day vitality for allergic sufferers.
Energy & Fatigue (6)
- Muesli with 4 g oat beta-glucans lowers glucose and insulin responses after a bread meal in healthy subjects
PubMed ID: 17426742
4 g oat beta-glucan acutely lowered postprandial glucose and insulin, supporting more stable post-meal glycemia.
- Changes in serum lipids and postprandial glucose and insulin concentrations after consumption of beverages with beta-glucans from oats or barley: a randomised dose-controlled trial
PubMed ID: 16015250
5 g oat β‑glucan reduced early postprandial glucose/insulin in this trial — supports steadier early post‑meal energy.
- Effect of Barley on Postprandial Blood Glucose Response and Appetite in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39599684
Marked reductions in postprandial glucose and insulin suggest more stable blood sugar and therefore steadier short‑term energy.
- Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure
PubMed ID: 17151592
Improved insulin handling could reduce postprandial energy swings for obese subjects (human RCT).
- Baker's yeast beta-glucan supplement reduces upper respiratory symptoms and improves mood state in stressed women
PubMed ID: 23378458
Reported improved vigor/energy in stressed adults—clinical evidence for increased day‑to‑day energy.
- Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial
PubMed ID: 33053626
Paramylon reduced physical/mental fatigue and improved task stability — supports steadier perceived energy.
Nutrient uptake (4)
- Beta-glucan incorporated into a fruit drink effectively lowers serum LDL-cholesterol concentrations
PubMed ID: 16522906
Human trial with fruit drink beta‑glucan reduced LDL/total cholesterol and sterol markers (lower sitosterol) consistent with altered intestinal sterol handling.
- Simultaneous intake of beta-glucan and plant stanol esters affects lipid metabolism in slightly hypercholesterolemic subjects
PubMed ID: 17311944
Beta-glucan increased bile acid synthesis and decreased cholesterol absorption with consequent LDL reductions — mechanistic nutrient-use changes.
- Effect of Barley on Postprandial Blood Glucose Response and Appetite in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39599684
Reduced postprandial glucose/insulin responses indicate altered nutrient absorption/metabolic handling favoring improved acute metabolic use.
- Effects of supplementation of beta-glucans on growth performance, nutrient digestibility, and immunity in weanling pigs
PubMed ID: 16699099
Weanling pig feeding showed clear, dose‑related increases in multiple nutrient digestibility measures (strong animal evidence for improved nutrient use).
Allergy relief (4)
- Effects of Chronic Barley Consumption on Upper Respiratory Tract Symptoms in Japanese Healthy Adults: A Randomized, Parallel-Group, Controlled Trial
PubMed ID: 39064742
Waxy barley daily reduced some cold/allergy symptom days (sneezing) — evidence for reduced allergic/URT symptoms.
- Effects after inhalation of (1-->3)-beta-D-glucan and relation to mould exposure in the home
PubMed ID: 12137243
Inhaled beta‑glucan reduced stimulated TNF‑α and altered IL‑10 in mold‑exposed people and increased lymphocytes — supports immunologic shifts relevant to allergic inflammation.
- Cow's milk-based beverage consumption in 1- to 4-year-olds and allergic manifestations: an RCT
PubMed ID: 26920136
Fortified milk (β‑glucan among other actives) reduced allergic manifestations in children — notable allergy outcome though multi‑nutrient product confounds attribution.
- Alleviation of seasonal allergic symptoms with superfine beta-1,3-glucan: a randomized study
PubMed ID: 17379290
Strong RCT evidence: orally absorbable superfine beta-1,3-glucan reduced seasonal/perennial allergic symptoms and blunted IgE rises.
Digestive support (4)
- The beneficial effects of Kampo medicine Dai-ken-chu-to after hepatic resection: a prospective randomized control study
PubMed ID: 23435143
Postoperative Kampo shortened time to bowel recovery and lowered inflammatory markers (includes β‑(1→3)‑D‑glucan biomarker)—supports faster return of gut function.
- Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome
PubMed ID: 28724171
IBD patients with IBS symptoms had less pain/bloating and better well‑being on a beta‑glucan–containing supplement.
- Clinical Outcomes after Oat Beta-Glucans Dietary Treatment in Gastritis Patients
PubMed ID: 34444949
30-day oral oat β‑glucan reduced gastric mucosal inflammation and increased fecal SCFAs—directly supports digestive comfort.
- Effect of beta-glucan, inositol and digestive enzymes in GI symptoms of patients with IBS
PubMed ID: 21796867
IBS patients given a beta‑glucan+inositol+enzymes supplement reported reduced bloating, gas and pain (clinical symptom improvement).
Skin health (4)
- Fungal chitin-glucan scaffold for managing diabetic xerosis of the feet in menopausal women
PubMed ID: 19743936
Topical chitin‑glucan formulation improved skin hydration and reduced foot xerosis in diabetic menopausal women—direct RCT evidence for skin moisturization.
- Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser: A prospective randomized vehicle-controlled parallel group study
PubMed ID: 35570397
Topical β‑glucan mildly improved stretch‑mark appearance and enhanced laser outcomes—supports aesthetic skin benefits.
- [Immune modulatory and therapeutic effect of lentinan on condyloma acuminatum]
PubMed ID: 11477860
Lentinan adjunct improved immune markers and lowered wart (condyloma) recurrence — positive dermatologic outcome.
- Chitin-glucan, a natural cell scaffold for skin moisturization and rejuvenation
PubMed ID: 19099547
Topical chitin–beta-glucan creams improved stratum corneum hydration, reduced TEWL and increased firmness in small controlled cosmetic studies.
Sleep quality (1)
- Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body's defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects
PubMed ID: 23340963
Trial reported reduced cold‑related sleep difficulties with yeast β‑glucan, indicating improved sleep during illness episodes.
Mood balance (1)
- Baker's yeast beta-glucan supplement reduces upper respiratory symptoms and improves mood state in stressed women
PubMed ID: 23378458
Wellmune trial reported significant improvements in global mood and vigor—direct clinical mood benefit.
Mental clarity (1)
- Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial
PubMed ID: 33053626
Paramylon (Euglena β‑1,3‑glucan) reduced mental fatigue and improved cognitive task performance — direct evidence for cognitive/clarity benefits.
Similar by evidence
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Products with Beta-Glucans
Search all204 products whose verified label declares Beta-Glucans — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.