Betaine HCL
6 benefits mapped to clinical evidence across supplements.
Dose per serving from products
680 products in our catalogue print how much Betaine HCL a serving holds.
Most common: 10 mg to 25 mg, 20% of 680 products.
| Dose per serving | Products |
|---|---|
| 5 mg or less | 28 |
| 5 mg to 10 mg | 55 |
| 10 mg to 25 mg | 134 |
| 25 mg to 50 mg | 63 |
| 50 mg to 100 mg | 133 |
| 100 mg to 250 mg | 104 |
| 250 mg to 500 mg | 83 |
| 500 mg to 1 g | 54 |
| over 1 g | 26 |
Dose per serving from research
5 study groups in 3 studies say how much Betaine HCL participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 g to 2.5 g, 60% of 5 study groups.
| Daily dose | Study groups |
|---|---|
| 1 g to 2.5 g | 3 |
| 2.5 g to 5 g | 2 |
Benefit Evidence
Choline/betaine ↑ uptake
+plasma choline betaine
Better fat absorption
Research sources
Metabolism (11)
- Assessment of urinary betaine as a marker of diabetes mellitus in cardiovascular patients
PubMed ID: 23936331
Large cohort: urinary betaine excretion strongly associates with diabetes and HbA1c — indicates relevant metabolic links (associative).
- Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial
PubMed ID: 27655522
Strong randomized evidence that betaine-containing nutraceutical improves one‑carbon metabolism (homocysteine), a core metabolic pathway.
- A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
PubMed ID: 31408467
Large RCT showing big homocysteine reduction with betaine+B‑vitamin — strong support for metabolic (methylation) benefits.
- Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
PubMed ID: 36717385
Large RCT in hyperhomocysteinemic adults: betaine+B‑vitamins reduced homocysteine and increased plasma betaine — robust metabolic evidence.
- Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
PubMed ID: 26771632
Betaine supplementation markedly altered DMG and influenced homocysteine — clear effects on one‑carbon metabolism.
- Metabolites and diabetes remission after weight loss
PubMed ID: 33627633
Circulating betaine/choline clusters predicted diabetes remission after weight‑loss interventions — observational link to improved metabolic outcomes.
- The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults
PubMed ID: 37764658
Choline adequacy associated with much greater training‑mediated strength gains — functional metabolic effect.
- Use of a Micronutrient Cocktail to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Adults with Obesity: A Randomized, Double-Blinded Pilot Clinical Trial
PubMed ID: 39202647
Multi‑micronutrient including betaine lowered liver fat and BMI in obese adults — supports metabolic benefits although effect cannot be ascribed to betaine alone.
- Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation
PubMed ID: 14699020
Human study: plasma betaine strongly predicted lower post‑methionine homocysteine; direct, high‑quality evidence that betaine affects one‑carbon metabolism.
- Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations
PubMed ID: 15941890
Large trial showing folic acid increased betaine (~+15%) and that higher betaine correlated with lower fasting homocysteine — strong human metabolic evidence.
- Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women
PubMed ID: 22172554
Choline increased betaine and modestly lowered homocysteine in postmenopausal women — direct support for improved methylation and metabolic health.
Nutrient uptake (11)
- Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
PubMed ID: 36717385
Large RCT of low‑dose B‑vitamins plus betaine lowered homocysteine and increased plasma betaine — supports improved methylation/nutrient use.
- Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis: A Randomized Placebo-Controlled Trial
PubMed ID: 26465792
Randomized trial in children with CF showed choline-rich lipid increased plasma betaine and measurably improved fat absorption (CFA).
- Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
PubMed ID: 26771632
Direct betaine supplementation produced large changes in DMG/homocysteine — strong evidence betaine alters whole‑body one‑carbon nutrient use.
- Choline metabolome response to prenatal choline supplementation across pregnancy: A randomized controlled trial
PubMed ID: 34820909
Maternal choline supplementation produced sustained rises in maternal betaine and fetal/placental metabolomes — strong evidence of enhanced systemic availability after supplementation.
- Choline supplementation for preterm infants: metabolism of four Deuterium-labeled choline compounds
PubMed ID: 36460779
Preterm infant randomized study showed rapid rises in plasma betaine after water‑soluble choline salts vs different PC processing — clear assimilation differences by form.
- The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults
PubMed ID: 37764658
Choline intake status influenced strength gains in resistance training, indicating major effects on nutrient utilization and functional outcomes.
- Choline and Betaine Levels in Plasma Mirror Choline Intake in Very Preterm Infants
PubMed ID: 38004152
In very low birth weight infants, higher enteral choline intake correlated strongly with plasma betaine — direct evidence dietary intake → circulating betaine (absorption/availability).
- Use of a Micronutrient Cocktail to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Adults with Obesity: A Randomized, Double-Blinded Pilot Clinical Trial
PubMed ID: 39202647
A supplement including 2 g/day betaine improved liver fat/BMI — supports betaine's role in broader metabolic nutrient handling (but multi‑ingredient).
- Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial
PubMed ID: 27655522
Randomized multicenter study: a betaine-containing nutraceutical produced large homocysteine reductions—strong evidence that supplemental betaine affects one‑carbon metabolism and systemic nutrient handling.
- A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
PubMed ID: 31408467
Large RCT: betaine+B‑vitamin drink substantially lowered homocysteine — strong evidence that betaine contributes to one‑carbon metabolism and overall nutrient (methyl donor) use.
- Non-Targeted Dried Blood Spot-Based Metabolomics Analysis Showed Rice Bran Supplementation Effects Multiple Metabolic Pathways during Infant Weaning and Growth in Mali
PubMed ID: 35276967
Infant rice‑bran (rich in betaines) improved weight and hemoglobin during weaning — clinical evidence of improved nutrient status/absorption.
Illness recovery (4)
- The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults
PubMed ID: 37764658
Strong human evidence: adequate choline intake associated with substantially larger strength gains during resistance training — indicates better recovery/utilization of dietary protein and nutrients.
- Effects of chronic betaine supplementation on performance in professional young soccer players during a competitive season: a double blind, randomized, placebo-controlled trial
PubMed ID: 34663363
14‑week betaine during a season produced marked improvements in jump, strength, sprint and aerobic measures — strong evidence for improved recovery/adaptation.
- Non-Targeted Dried Blood Spot-Based Metabolomics Analysis Showed Rice Bran Supplementation Effects Multiple Metabolic Pathways during Infant Weaning and Growth in Mali
PubMed ID: 35276967
Infant growth and hemoglobin improvements with rice‑bran indicate better nutrition‑driven growth/recovery in a vulnerable population.
- Betaine supplementation improves CrossFit performance and increases testosterone levels, but has no influence on Wingate power: randomized crossover trial
PubMed ID: 37409757
Short‑term betaine improved CrossFit repeated‑workout performance — supports acute enhancement of recovery/work capacity.
Digestive support (2)
- The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults
PubMed ID: 37764658
Habitual choline intake strongly associated with bigger strength gains during resistance training, implying improved utilization of dietary protein/cofactors for muscle anabolism.
- Evaluation of the clinical efficacy of a betaine-containing mouthwash and an intraoral device for the treatment of dry mouth
PubMed ID: 21950587
Mouthwash improved xerostomia symptoms and salivary flow over 4 weeks → likely improves comfort while eating.
Energy & Fatigue (2)
- Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis: A Randomized Placebo-Controlled Trial
PubMed ID: 26465792
By increasing fat absorption in CF children, the choline-rich lipid likely increased energetic yield from meals.
- Effects of chronic betaine supplementation on performance in professional young soccer players during a competitive season: a double blind, randomized, placebo-controlled trial
PubMed ID: 34663363
14‑week betaine improved aerobic and strength performance in athletes — suggests improved utilization of dietary energy substrates.
Muscle growth (2)
- The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults
PubMed ID: 37764658
Clear human evidence: inadequate choline intake blunted strength gains in resistance training — strong indicator of impaired protein utilization without sufficient choline/betaine.
- Effects of chronic betaine supplementation on performance in professional young soccer players during a competitive season: a double blind, randomized, placebo-controlled trial
PubMed ID: 34663363
14‑week betaine produced larger gains in strength/power and jump performance, supporting enhanced protein/anabolic utilization.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Betaine HCL
Search all925 products whose verified label declares Betaine HCL — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.