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Rutin

13 benefits mapped to clinical evidence across supplements.

Dose per serving from products

1,187 products in our catalogue print how much Rutin a serving holds.

Most common: 10 mg to 25 mg, 27% of 1,187 products.

Dose per servingProducts
2.5 mg or less
54
2.5 mg to 5 mg
179
5 mg to 10 mg
115
10 mg to 25 mg
324
25 mg to 50 mg
220
50 mg to 100 mg
171
100 mg to 250 mg
78
over 250 mg
46

Dose per serving from research

39 study groups in 27 studies say how much Rutin participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mg to 1 g, 38% of 39 study groups.

Daily doseStudy groups
100 mg or less
1
100 mg to 250 mg
3
250 mg to 500 mg
8
500 mg to 1 g
15
1 g to 2.5 g
10
over 2.5 g
2

See every study group

Benefit Evidence

Leg swelling/symptoms

Microcirculation/flow improved

4,011 people

Venous swelling ↓

Flight edema 12%→8%

3,631 people

↓ swelling/symptoms

↑ venous function

1,792 people
Inflammation
Moderate

Inflammation markers ↓

ESR/CRP↓, IL-6↓, MPO↓

318 people
Antioxidant
Moderate

Oxidative stress↓, GSH↑

TAC↑, BAP↑

227 people
Metabolism
Moderate

Weight/fat ↓, FFM ↑

Glucose/lipids/inflammation improved

170 people

Irritation/redness ↓

Wrinkles/elasticity ↑

105 people

Knee: LFI −3.6

Hip: WOMAC improved

193 people

Macular function +38%

+30%; dry eye

Vision, edema improved

91 people

Pain/swelling/tiredness +11-24%

1,973 people

Clot-busting, flow +venous

RBC aggregation, viscosity -

85 people

Strength +13%; gait +8%

Muscle thickness +3-5%

37 people

PLE↓ severity/itch

significant reduction

30 people

Research sources

Blood circulation (24)
  1. The LONFLIT4-VENORUTON study: a randomized trial prophylaxis of flight-edema in normal subjects

    PubMed ID: 12643319

    Venoruton markedly reduced flight-related leg swelling and symptoms in healthy travellers (consistent objective and subjective effects).

  2. The LONFLIT4-Venoruton Study: a randomized trial--prophylaxis of flight-edema in venous patients

    PubMed ID: 12678187

    Venoruton (hydroxyethylrutosides) substantially reduced long‑haul flight leg swelling and discomfort (objective protection of circulation).

  3. HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides) in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial

    PubMed ID: 12011966

    HR reduced microcirculatory abnormalities, ankle swelling and symptoms in venous hypertension.

  4. Oxerutins (Venoruton): efficacy in chronic venous insufficiency--a double-blind, randomized, controlled study

    PubMed ID: 12025912

    Oxerutins improved venous capacity and LRR with objective microcirculatory improvements vs placebo.

  5. Treatment of edema and increased capillary filtration in venous hypertension with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a clinical, prospective, placebo-controlled, randomized, dose-ranging trial

    PubMed ID: 12011969

    Dose-ranging HR trial showed dose-dependent reduction in capillary filtration and symptom improvement.

  6. Flight microangiopathy in medium-to-long distance flights: prevention of edema and microcirculation alterations with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a prospective, randomized, controlled trial

    PubMed ID: 12011968

    HR preserved transcutaneous Po2, resting flux and venoarteriolar responses during long flights.

  7. Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study

    PubMed ID: 11922398

    Troxerutin+carbazochrome injection reduced bleeding and related postoperative signs vs placebo.

  8. [Effectiveness and safety of hydroxyethyl-rutosides in the local treatment of symptoms of venous insufficiency during air travel]

    PubMed ID: 10467532

    Topical hydroxyethyl-rutoside gel reduced ankle circumference and symptoms during long flights vs placebo.

  9. Investigation of the therapeutic equivalence of different galenical preparations of O-(beta-hydroxyethyl)-rutosides following multiple dose peroral administration

    PubMed ID: 8737632

    Different HR oral formulations significantly reduced leg-volume (edema) vs placebo.

  10. Investigation of the efficacy of oxerutins compared to placebo in patients with chronic venous insufficiency treated with compression stockings

    PubMed ID: 8737630

    Adding oxerutins to compression stockings produced significantly greater edema reduction vs stockings alone (large RCT—clinical circulation benefit).

  11. Fibrinolysis and hemorheology in chronic venous insufficiency: a double blind study of troxerutin efficiency

    PubMed ID: 7593149

    Randomized trial: troxerutin reduced RBC aggregation and improved fibrinolysis markers—strong mechanistic support for improved circulation.

  12. A randomized, double-masked study on the treatment of retinal vein occlusion with troxerutin

    PubMed ID: 7943118

    In retinal vein occlusion troxerutin improved macular edema and reduced RBC aggregation—clinical and rheological indicators of improved local blood flow.

  13. Hydroxyethylrutosides in elderly patients with chronic venous insufficiency: its efficacy and tolerability

    PubMed ID: 8034203

    DB trial in elderly with venous insufficiency: symptom score and ankle/calf swelling reduced more than placebo (clinical circulation endpoints).

  14. Meta-analysis of hydroxyethylrutosides in the treatment of chronic venous insufficiency

    PubMed ID: 7975870

    Meta-analysis: hydroxyethylrutosides modestly but significantly improved leg pain, swelling and tired legs—consistent circulatory benefit across trials.

  15. Acute effects of hydroxyethylrutosides on capillary filtration in normal volunteers, patients with venous hypertension and in patients with diabetic microangiopathy (a dose comparison study)

    PubMed ID: 1580094

    Clear, dose-dependent reductions in capillary filtration (microvascular permeability)—strong microcirculatory evidence.

  16. [Effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency]

    PubMed ID: 11292962

    Multi-ingredient product including rutin reduced leg swelling and symptoms in CVI; contribution of rutin plausible but not isolated.

  17. Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial

    PubMed ID: 23761871

    Veno-active drugs as a class improved venous disease QoL; troxerutin-containing arm included though agent-specific effects mixed.

  18. HR, 0-(beta-hydroxyethyl)-rutosides, in comparison with diosmin+hesperidin in chronic venous insufficiency and venous microangiopathy: an independent, prospective, comparative registry study

    PubMed ID: 15678250

    Hydroxyethylrutosides produced large reductions in resting skin flux, ankle swelling rate and symptom scores vs comparator (strong microcirculatory evidence).

  19. HR (Venoruton1000, Paroven, 0-[beta-hydroxyethyl]-rutosides) vs. Daflon 500 in chronic venous disease and microangiopathy: an independent prospective, controlled, randomized trial

    PubMed ID: 12232562

    Large randomized comparison showed Venoruton improved objective microcirculatory parameters (RF, RAS) vs diosmin.

  20. Calcium dobesilate and oxerutin: effectiveness of combination therapy

    PubMed ID: 20348452

    Combination including oxerutin reduced venous symptoms more than single agents (support for venous circulation symptom relief).

  21. An open-label, randomized multicenter study comparing the efficacy and safety of Cyclo 3 Fort versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency

    PubMed ID: 10917578

    Combination product outperformed rutoside alone, but rutoside still had measurable circulation effects.

  22. Additional oxerutin therapy to promote deep vein thrombus resolution (RESOLVE-DVT): a randomized controlled pilot trial

    PubMed ID: 41197809

    Oxerutin reduced residual venous obstruction after DVT, supporting improved venous blood flow and thrombus resolution.

  23. Flight microangiopathy on long-haul flights: prevention of edema and microcirculation alterations with Venoruton

    PubMed ID: 12812378

    Hydroxyethylrutosides reduced flight-associated microcirculatory deterioration and limited ankle swelling (objective microvascular protection).

  24. The efficiency of O-(beta-hydroxyethyl)-rutosides in reducing the incidence of superficial venous insufficiency in patients with calf muscle pump dysfunction

    PubMed ID: 26924360

    Oxerutin strongly reduced superficial venous reflux incidence during immobilization, indicating improved venous flow/health.

Swelling relief (18)
  1. Hydroxyethylrutosides in elderly patients with chronic venous insufficiency: its efficacy and tolerability

    PubMed ID: 8034203

    Elderly CVI trial showed significant reduction in ankle/calf circumference compared with placebo (clinical edema endpoint).

  2. HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides) in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial

    PubMed ID: 12011966

    HR decreased rate of ankle swelling and improved symptoms in venous hypertensive patients.

  3. Treatment of edema and increased capillary filtration in venous hypertension with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a clinical, prospective, placebo-controlled, randomized, dose-ranging trial

    PubMed ID: 12011969

    Dose-dependent reduction in capillary filtration and ankle edema documented.

  4. Flight microangiopathy in medium-to-long distance flights: prevention of edema and microcirculation alterations with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a prospective, randomized, controlled trial

    PubMed ID: 12011968

    HR prevented ankle swelling during long flights in varicose patients.

  5. Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study

    PubMed ID: 11922398

    Intramuscular troxerutin combo significantly reduced postoperative swelling after hemorrhoid surgery.

  6. [Effectiveness and safety of hydroxyethyl-rutosides in the local treatment of symptoms of venous insufficiency during air travel]

    PubMed ID: 10467532

    Topical HR gel reduced ankle circumference and edema signs vs placebo in a crossover trial.

  7. Investigation of the therapeutic equivalence of different galenical preparations of O-(beta-hydroxyethyl)-rutosides following multiple dose peroral administration

    PubMed ID: 8737632

    Multiple HR oral preparations significantly reduced leg-volume vs placebo after 12 weeks.

  8. Investigation of the efficacy of oxerutins compared to placebo in patients with chronic venous insufficiency treated with compression stockings

    PubMed ID: 8737630

    Well-sized randomized DB study: oxerutins + stockings produced significantly greater leg-volume reduction vs stockings alone.

  9. [Effectiveness of beta-hydroxyethylrutoside in patients with varicose veins in pregnancy]

    PubMed ID: 7778354

    Pregnancy study reported reductions in leg circumference and symptom scores with hydroxyethylrutosides (supporting edema reduction).

  10. Meta-analysis of hydroxyethylrutosides in the treatment of chronic venous insufficiency

    PubMed ID: 7975870

    Meta-analysis: hydroxyethylrutosides modestly but significantly improved swelling vs placebo across multiple trials.

  11. Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled clinical trial

    PubMed ID: 8858269

    Buckwheat (rutin-rich) tea prevented worsening of leg swelling vs placebo in CVI (RCT; modest protective effect).

  12. [Effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency]

    PubMed ID: 11292962

    Combination including rutin reduced leg swelling and symptoms in chronic venous insufficiency (open randomized; rutin contribution plausible).

  13. Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial

    PubMed ID: 25893991

    Troxerutin-containing flavonoid mix reduced pain, bleeding and edema persistence in acute hemorrhoid crisis (randomized triple‑blind trial).

  14. Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency

    PubMed ID: 16518519

    Oxerutins produced marked improvement in venous-related QoL and reduced edema vs comparator (clinically meaningful edema reduction).

  15. A prospective, randomized, double-blind, placebo-controlled clinical trial comparing the efficacy of systemic enzyme therapy for edema control in orthognathic surgery using ultrasound scan to measure facial swelling

    PubMed ID: 23566694

    Systemic enzyme therapy reduced postoperative facial soft‑tissue swelling more than placebo (small RCT).

  16. The LONFLIT4-VENORUTON study: a randomized trial prophylaxis of flight-edema in normal subjects

    PubMed ID: 12643319

    Venoruton markedly limited flight-related ankle increases and symptoms in healthy travellers (strong edema prevention).

  17. The LONFLIT4-Venoruton Study: a randomized trial--prophylaxis of flight-edema in venous patients

    PubMed ID: 12678187

    Venoruton greatly reduced flight-associated leg swelling and subjective discomfort (large and clinically relevant edema reduction).

  18. The efficacy and safety of a coumarin-/troxerutin-combination (SB-LOT) in patients with chronic venous insufficiency: a double blind placebo-controlled randomised study

    PubMed ID: 12236023

    Combination drug (coumarin + troxerutin) reduced leg-volume recurrence and improved complaint scores vs placebo after stopping compression (objective edema benefit).

Vascular health (17)
  1. Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial

    PubMed ID: 25893991

    Troxerutin-related flavonoid mix improved hemorrhoid outcomes (pain, bleeding, edema), consistent with strengthened venous/hemorrhoidal integrity.

  2. Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I-III degree hemorroidal disease: a double-blind multicenter prospective comparative study

    PubMed ID: 29934701

    Large RCT with a rutin-containing mix improved hemorrhoid-related outcomes and satisfaction vs comparator, supporting venous symptom benefit (multi‑ingredient).

  3. Acute effects of hydroxyethylrutosides on capillary filtration in normal volunteers, patients with venous hypertension and in patients with diabetic microangiopathy (a dose comparison study)

    PubMed ID: 1580094

    Controlled dose-comparison study showed rapid, dose-dependent reductions in capillary filtration (direct evidence of strengthened capillary barrier).

  4. Fibrinolysis and hemorheology in chronic venous insufficiency: a double blind study of troxerutin efficiency

    PubMed ID: 7593149

    Troxerutin improved RBC aggregation and fibrinolysis markers which support reduced venous stasis and venous health.

  5. Investigation of the efficacy of oxerutins compared to placebo in patients with chronic venous insufficiency treated with compression stockings

    PubMed ID: 8737630

    Oxerutins added to stockings led to greater edema reduction than stockings alone (clinical improvement in venous disease consistent with enhanced venous function/integrity).

  6. Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study

    PubMed ID: 11922398

    Troxerutin-containing injection improved postoperative venous/hemorrhoidal outcomes vs placebo.

  7. Trihydroxyethylrutosides in the treatment of hemorrhoids of pregnancy: a double-blind placebo-controlled trial

    PubMed ID: 11804247

    HR improved hemorrhoid symptoms in pregnancy vs placebo, indicating venous support in pelvic venous beds.

  8. Treatment of edema and increased capillary filtration in venous hypertension with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a clinical, prospective, placebo-controlled, randomized, dose-ranging trial

    PubMed ID: 12011969

    Dose-dependent reduction in capillary filtration rate and edema demonstrates robust capillary/vascular mechanical effects.

  9. Oxerutins (Venoruton): efficacy in chronic venous insufficiency--a double-blind, randomized, controlled study

    PubMed ID: 12025912

    Oxerutins improved venous capacity and capillaroscopy/temperature, supporting venous structural/functional benefit.

  10. HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides) in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial

    PubMed ID: 12011966

    HR reduced microcirculatory abnormalities and edema in venous hypertensive patients—supports vein function integrity.

  11. The efficacy and safety of a coumarin-/troxerutin-combination (SB-LOT) in patients with chronic venous insufficiency: a double blind placebo-controlled randomised study

    PubMed ID: 12236023

    Coumarin + troxerutin combination reduced leg-volume recurrence and improved complaints after compression cessation (supports venous function).

  12. The efficiency of O-(beta-hydroxyethyl)-rutosides in reducing the incidence of superficial venous insufficiency in patients with calf muscle pump dysfunction

    PubMed ID: 26924360

    Oxerutin substantially lowered incidence of superficial venous reflux in immobilized patients (strong RCT evidence for venous protection).

  13. Flight microangiopathy on long-haul flights: prevention of edema and microcirculation alterations with Venoruton

    PubMed ID: 12812378

    Hydroxyethylrutosides limited flight-associated microcirculatory changes (supports capillary protection in acute stress).

  14. Additional oxerutin therapy to promote deep vein thrombus resolution (RESOLVE-DVT): a randomized controlled pilot trial

    PubMed ID: 41197809

    Oxerutin reduced residual venous obstruction after DVT and lowered vascular inflammatory biomarkers, supporting improved vein healing/integrity.

  15. HR (Venoruton1000, Paroven, 0-[beta-hydroxyethyl]-rutosides) vs. Daflon 500 in chronic venous disease and microangiopathy: an independent prospective, controlled, randomized trial

    PubMed ID: 12232562

    Venoruton improved objective microcirculatory parameters and symptoms in chronic venous disease.

  16. HR, 0-(beta-hydroxyethyl)-rutosides, in comparison with diosmin+hesperidin in chronic venous insufficiency and venous microangiopathy: an independent, prospective, comparative registry study

    PubMed ID: 15678250

    Hydroxyethylrutosides improved microcirculatory measures and symptoms vs comparator—consistent with enhanced venous/capillary integrity.

  17. Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency

    PubMed ID: 16518519

    Oxerutins produced large improvements in venous-related QoL and edema, supporting vein integrity/venotonic benefit (moderate evidence).

Inflammation (6)
  1. Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study

    PubMed ID: 11922398

    Intramuscular troxerutin+carbazochrome significantly reduced pain, bleeding and swelling after hemorrhoid surgery.

  2. Additional oxerutin therapy to promote deep vein thrombus resolution (RESOLVE-DVT): a randomized controlled pilot trial

    PubMed ID: 41197809

    Oxerutin lowered inflammatory biomarkers (ICAM‑1, IL‑6) in DVT study, suggesting anti-inflammatory vascular effects.

  3. The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial

    PubMed ID: 36101997

    Rutin reduced IL‑6 and other inflammatory markers in T2DM patients.

  4. Study of the soothing effects of troxerutin in alleviating skin sensitivity

    PubMed ID: 38720512

    Troxerutin reduced capsaicin/heat-induced skin irritation and molecular markers of irritation/inflammation in clinical testing.

  5. Eating buckwheat cookies is associated with the reduction in serum levels of myeloperoxidase and cholesterol: a double blind crossover study in day-care centre staffs

    PubMed ID: 21931228

    Tartary buckwheat (high in rutin) reduced serum MPO (~16%), an inflammation/oxidative marker (moderate evidence).

  6. A clinical trial of hydroxyethylrutosides in the treatment of haemorrhoids of pregnancy

    PubMed ID: 1568520

    Well-powered RCT in pregnant patients: hydroxyethylrutosides reduced haemorrhoid symptoms/signs (anti-inflammatory and symptomatic effects).

Antioxidant (5)
  1. Variations in plasma free radicals in patients with venous hypertension with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a clinical, prospective, placebo-controlled, randomized trial

    PubMed ID: 12011970

    Hydroxyethylrutoside trial demonstrated decreased plasma free radicals vs placebo.

  2. Effects of enzymatically modified isoquercitrin in supplementary protein powder on athlete body composition: a randomized, placebo-controlled, double-blind trial

    PubMed ID: 31500646

    EMIQ (bioavailable rutin derivative) improved antioxidant index (BAP/d-ROMs) in athletes.

  3. Protective effects of N-acetylcysteine and rutin on the lipid peroxidation of the lung epithelium during the adult respiratory distress syndrome

    PubMed ID: 10638663

    ARDS trial (NAC + rutin) showed earlier reductions in lipid-peroxidation markers and ↑GSH—clinical biochemical antioxidant signal.

  4. Eating buckwheat cookies is associated with the reduction in serum levels of myeloperoxidase and cholesterol: a double blind crossover study in day-care centre staffs

    PubMed ID: 21931228

    High-rutin tartary buckwheat reduced myeloperoxidase (MPO), an oxidative/inflammatory marker (moderate direct evidence).

  5. The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial

    PubMed ID: 36101997

    500 mg/day rutin reduced oxidative stress markers (MDA) and increased total antioxidant capacity.

Metabolism (3)
  1. The reduction impact of monoglucosyl rutin on abdominal visceral fat: A randomized, placebo-controlled, double-blind, parallel-group

    PubMed ID: 32935866

    Enzymatically modified water-soluble rutin reduced abdominal visceral fat area in an 8-week RCT.

  2. Eating buckwheat cookies is associated with the reduction in serum levels of myeloperoxidase and cholesterol: a double blind crossover study in day-care centre staffs

    PubMed ID: 21931228

    High-rutin tartary buckwheat lowered total and HDL cholesterol in a double-blind crossover (nutritional high-rutin intervention).

  3. The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial

    PubMed ID: 36101997

    500 mg/day rutin in T2DM improved FBG, HbA1c, HOMA-IR and lipid markers in a placebo-controlled trial.

Skin health (3)
  1. Study of the soothing effects of troxerutin in alleviating skin sensitivity

    PubMed ID: 38720512

    Troxerutin produced prompt and preventive soothing effects on skin irritation and redness in clinical testing.

  2. Biological effects of rutin on skin aging

    PubMed ID: 27220601

    Topical rutin cream in a double‑blind human study improved skin elasticity and reduced wrinkle metrics over 4 weeks (direct evidence).

  3. Effects of topically applied antioxidants in experimentally provoked polymorphous light eruption

    PubMed ID: 9529558

    Topical alpha-glycosylrutin–containing creams lowered PLE severity and pruritus in susceptible subjects.

Joint comfort (2)
  1. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs

    PubMed ID: 16539815

    Rutoside-containing enzyme combo provided non-inferior symptomatic relief vs diclofenac in hip OA (moderate but confounded).

  2. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study

    PubMed ID: 15278753

    Rutoside-containing oral enzyme combo produced symptomatic improvement in knee OA comparable to diclofenac (moderate evidence, multi-ingredient product).

Eye health (2)
  1. Treatment of glaucomatous patients by means of food supplement to reduce the ocular discomfort: a double blind randomized trial

    PubMed ID: 23661528

    A supplement containing rutin improved ocular protection index and dry-eye symptoms in glaucoma patients using preserved drops (pilot RCT; multi-ingredient).

  2. A randomized, double-masked study on the treatment of retinal vein occlusion with troxerutin

    PubMed ID: 7943118

    Randomized double-masked trial in retinal vein occlusion: troxerutin improved visual acuity and reduced macular edema and RBC aggregability (strong ocular benefit signal).

Wellbeing (1)
  1. Meta-analysis of hydroxyethylrutosides in the treatment of chronic venous insufficiency

    PubMed ID: 7975870

    Meta-analysis showed modest improvements in symptoms (pain, swelling, tired legs) across trials—broad clinical benefit consistent with overall wellness.

Heart health (1)
  1. Fibrinolysis and hemorheology in chronic venous insufficiency: a double blind study of troxerutin efficiency

    PubMed ID: 7593149

    Troxerutin reduced RBC aggregation and improved fibrinolytic markers—mechanistic signals relevant to cardiovascular health.

Energy & Fatigue (1)
  1. Supplementation with Whey Protein, Omega-3 Fatty Acids and Polyphenols Combined with Electrical Muscle Stimulation Increases Muscle Strength in Elderly Adults with Limited Mobility: A Randomized Controlled Trial

    PubMed ID: 32585837

    Polyphenol (incl. rutin) addition improved muscle strength and gait speed in mobility‑limited elderly, implying functional energy benefits.

Allergy relief (1)
  1. Effects of topically applied antioxidants in experimentally provoked polymorphous light eruption

    PubMed ID: 9529558

    Topical antioxidant formulations containing an alpha-glycosylrutin derivative reduced photodermatosis (PLE) reactions and itch.

Similar by evidence

Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.

Products with Rutin

Search all

1921 products whose verified label declares Rutin — not every bottle that mentions it in a title.

Being studied right now

Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.