Riboflavin
20 benefits mapped to clinical evidence across supplements.
Dose per serving from products
14,279 products in our catalogue print how much Riboflavin a serving holds.
Most common: 1 mg to 2.5 mg, 28% of 14,279 products.
| Dose per serving | Products |
|---|---|
| 250 mcg or less | 674 |
| 250 mcg to 500 mcg | 951 |
| 500 mcg to 1 mg | 1,116 |
| 1 mg to 2.5 mg | 3,930 |
| 2.5 mg to 5 mg | 2,006 |
| 5 mg to 10 mg | 1,494 |
| 10 mg to 25 mg | 1,826 |
| 25 mg to 50 mg | 1,232 |
| 50 mg to 100 mg | 806 |
| over 100 mg | 244 |
Dose per serving from research
109 study groups in 68 studies say how much Riboflavin participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 21% of 109 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg to 250 mcg | 9 |
| 250 mcg to 500 mcg | 3 |
| 500 mcg to 1 mg | 6 |
| 1 mg to 2.5 mg | 23 |
| 2.5 mg to 5 mg | 14 |
| 5 mg to 10 mg | 16 |
| 10 mg to 25 mg | 10 |
| 25 mg to 50 mg | 9 |
| 50 mg to 100 mg | 15 |
| over 100 mg | 4 |
Commonly used together
65 of 107 study groups took Riboflavin with something else. Shown: what 3 or more different studies gave. The 10 most common of 20.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Vitamin B12 | 26 |
| Vitamin B6 | 25 |
| Folic Acid | 23 |
| Thiamine | 18 |
| Iron | 16 |
| Niacin | 16 |
| Zinc | 16 |
| Vitamin E | 13 |
| Vitamin A | 11 |
| Vitamin C | 10 |
Benefit Evidence
Keratoconus flattening +1.5 D
Cataract reduction −43%
Kmax flattening + vision
cataract risk −44%
Anemia/iron status +9 g/L
Homocysteine/metabolism −23.6%
Folate↓ Hcy↓
B2 status↑
Oxidative/antioxidant + improved
Vision/cornea + better
Blood markers, lesions heal
Cornea flattens ~−2 D
Nerve function +
Neuropathy symptoms -0.92
Neurological recovery +25%
Neuropathy symptoms/pain
Stroke/ischemia recovery
Migraine days -44%
Riboflavin status, +83%
Fatigue/function, -25 pts
Fatigue ↓, endurance ↑
+3.2 min endurance
Pregnancy HTN −38%
Anemia/birthweight improved
Pregnancy: ↑ birth weight
Pregnancy: ↓ anemia/deficiency
Pregnancy: +10% birth weight
Growth + child weight
+0.42 WAZ
+11 pp adequacy
Growth support +1.3 cm
Micronutrient adequacy +11 pp
Migraine relief: −1.8 days
Stroke recovery: −25% lesion
Cognition/fatigue: improved scores
Iron markers +9
+57 pp anemia
B2 status/iron stores
Iron status ↑
B2/Fe deficiencies ↓
Cognition +14.2%
Attention/memory improved
School ability higher
Immune illness↓
Infections↓ 29-38%
Fewer infections, shorter illness
Better autonomic, viral markers
Acne improvement +2.6%
Less pain, fewer side effects
Angular stomatitis 30.4%→0%
Acne lesions ↓; less irritation
Keratoconus flattening +1.5 D
Cataract reduction −43%
Kmax flattening + vision
cataract risk −44%
Anemia/iron status +9 g/L
Homocysteine/metabolism −23.6%
Folate↓ Hcy↓
B2 status↑
Oxidative/antioxidant + improved
Vision/cornea + better
Blood markers, lesions heal
Cornea flattens ~−2 D
Nerve function +
Neuropathy symptoms -0.92
Neurological recovery +25%
Neuropathy symptoms/pain
Stroke/ischemia recovery
Migraine days -44%
Riboflavin status, +83%
Fatigue/function, -25 pts
Fatigue ↓, endurance ↑
+3.2 min endurance
Pregnancy HTN −38%
Anemia/birthweight improved
Pregnancy: ↑ birth weight
Pregnancy: ↓ anemia/deficiency
Pregnancy: +10% birth weight
Growth + child weight
+0.42 WAZ
+11 pp adequacy
Growth support +1.3 cm
Micronutrient adequacy +11 pp
Migraine relief: −1.8 days
Stroke recovery: −25% lesion
Cognition/fatigue: improved scores
Iron markers +9
+57 pp anemia
B2 status/iron stores
Iron status ↑
B2/Fe deficiencies ↓
Immune illness↓
Infections↓ 29-38%
Fewer infections, shorter illness
Better autonomic, viral markers
Acne improvement +2.6%
Less pain, fewer side effects
Angular stomatitis 30.4%→0%
Acne lesions ↓; less irritation
Research sources
Eye health (62)
- A randomised controlled trial on cross-linking protocols for the treatment of progressive keratoconus using isoosmolar and hypoosmolar riboflavin with the addition of sterile water in thin corneae
PubMed ID: 40630024
One‑year RCT comparing isoosmolar and hypoosmolar riboflavin protocols showed similar efficacy but major intraoperative safety differences—direct and clinically important ocular evidence for riboflavin use in CXL.
- Five-year results of a prospective, randomised, contralateral eye trial of corneal crosslinking for keratoconus
PubMed ID: 34117699
5‑year randomized contralateral trial showing durable stabilization/improvement after riboflavin‑UVA CXL — very strong long‑term eye benefit.
- EpiSmart Crosslinking for Keratoconus: A Phase 2 Study
PubMed ID: 36173242
Large phase‑2 study of epi‑on riboflavin solution showed improved visual acuity and modest keratometry flattening with good safety — strong eye‑procedure evidence.
- Comparison of Continuous versus Pulsed Mode in Accelerated Corneal Collagen Cross-linking for Keratoconus
PubMed ID: 38162570
Clinical trial of riboflavin-assisted corneal cross-linking showed improvements in corneal shape and stiffness relevant to keratoconus—direct eye-health benefit.
- Assessment of the Predictive Ability of Theranostics for Corneal Cross-linking in Treating Keratoconus: A Randomized Clinical Trial
PubMed ID: 38908553
Theranostic imaging of corneal riboflavin concentration accurately predicted one-year corneal flattening and visual improvement after CXL—strong evidence linking riboflavin use to ocular outcomes.
- Randomized clinical trial comparing customized corneal crosslinking: epi-on in high oxygen and epi-off in room air for keratoconus
PubMed ID: 38465837
Randomized intra-individual trial of customized riboflavin-based CXL showed significant vision and keratometry improvements at 24 months—robust eye-health evidence.
- Early findings in a randomised controlled trial on crosslinking protocols using isoosmolar and hypoosmolar riboflavin for the treatment of progressive keratoconus
PubMed ID: 38970233
Randomized clinical trial directly comparing isoosmolar vs hypoosmolar riboflavin in corneal crosslinking found large intraoperative safety differences (corneal thinning, sterile‑water rescue)—strong, direct ocular relevance for riboflavin formulations.
- Accelerated Epithelium-off Corneal Cross-linking With Preservation of a Central Epithelial Island in the Management of Paracentral Progressive Keratoconus: A Comparative Clinical Trial
PubMed ID: 40340672
An epithelium‑preserving CXL technique using riboflavin produced less early pain/haze and improved 1‑year vision/Kmax vs full‑epithelium removal—clinically relevant ocular outcomes tied to riboflavin‑based CXL.
- Aqueous Proteomic and Metabolomic Profiles in Low-Energy vs High-Energy Femtosecond Laser-Assisted Cataract Surgery
PubMed ID: 39775700
Proteomic/metabolomic analysis after femtosecond cataract surgery showed changes in riboflavin‑related pathways and oxidative stress—links riboflavin metabolism to ocular surgical biology (indirect).
- Evaluation of corneal cross-linking as adjuvant therapy for the management of fungal keratitis
PubMed ID: 31041523
Riboflavin‑assisted CXL adjunct to antifungal therapy accelerated healing and fungal clearance — direct clinical ocular benefit of the riboflavin procedure.
- Standard cross-linking protocol versus accelerated and transepithelial cross-linking protocols for treatment of paediatric keratoconus: a 2-year comparative study
PubMed ID: 31654497
Standard (Dresden) riboflavin CXL in children clearly stopped progression and improved vision vs other protocols — strong direct evidence of eye protection from the riboflavin procedure.
- Long-term Results of an Accelerated Corneal Cross-linking Protocol (18 mW/cm2) for the Treatment of Progressive Keratoconus
PubMed ID: 26314662
Intra‑subject trial: standard (30‑min) riboflavin CXL flattened cornea more than accelerated protocol — relevant to procedural eye health.
- Transepithelial versus epithelium-off corneal cross-linking for the treatment of progressive keratoconus: a randomized controlled trial
PubMed ID: 25703475
Randomized trial comparing epi‑off vs transepithelial CXL: epi‑off produced greater corneal flattening—directly relevant to riboflavin CXL outcomes.
- Impression cytologic analysis after corneal cross-linking and insertion of corneal ring segments for keratoconus: two-year results
PubMed ID: 22760800
Conjunctival cell/goblet cell improvements observed after CXL or riboflavin drops — ocular surface health signal.
- The Association of Dietary Lutein plus Zeaxanthin and B Vitamins with Cataracts in the Age-Related Eye Disease Study: AREDS Report No. 37
PubMed ID: 25972257
Observational cohort linking higher dietary riboflavin with lower odds of some cataract types—relevant to lens/eye health though not interventional.
- Treatment of glaucomatous patients by means of food supplement to reduce the ocular discomfort: a double blind randomized trial
PubMed ID: 23661528
Multi‑ingredient supplement containing B2 improved tear‑film metrics and dry‑eye symptoms versus placebo (ocular surface benefit, but multi‑ingredient).
- The Linxian cataract studies. Two nutrition intervention trials
PubMed ID: 8363468
In malnourished older adults, regimens including riboflavin were associated with large reductions in nuclear cataract prevalence (strong subgroup signal).
- [Preliminary report on the results of nutrition prevention trials of cancer and other common diseases among residents in Linxian, China]
PubMed ID: 8261860
Large Linxian nutrition trials (multi‑nutrient, including riboflavin) reported notable cataract reductions in some arms — supportive but not riboflavin‑specific.
- A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: preliminary results
PubMed ID: 18811118
Riboflavin (0.1%) plus UVA corneal cross‑linking is the essential active treatment; strong, direct clinical benefit in stabilizing/flattening progressive keratoconus.
- Impression cytologic analysis after corneal collagen cross-linking using riboflavin and ultraviolet-A light in the treatment of keratoconus
PubMed ID: 20622670
Topical riboflavin used in CXL altered conjunctival/epithelial cytology and improved epithelial morphology—direct ocular‑surface effects of riboflavin application.
- Natural history of corneal haze after collagen crosslinking for keratoconus and corneal ectasia: Scheimpflug and biomicroscopic analysis
PubMed ID: 21111314
Quantified corneal haze time‑course after riboflavin‑based CXL shows measurable, predictable ocular tissue effects attributable to riboflavin‑UVA procedure.
- Corneal collagen crosslinking for keratoconus and corneal ectasia: One-year results
PubMed ID: 21183110
Topical riboflavin + UVA corneal crosslinking produced clear clinical improvements in vision and corneal shape; direct, procedure‑specific effect.
- Corneal thickness changes after corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results
PubMed ID: 21420594
Corneal pachymetry changed after riboflavin+UVA crosslinking with partial recovery by 1 year; direct procedural impact on cornea.
- Corneal topography indices after corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results
PubMed ID: 21700105
CXL with riboflavin produced consistent significant improvements in multiple corneal shape indices at 1 year.
- Higher-order aberrations after corneal collagen crosslinking for keratoconus and corneal ectasia
PubMed ID: 22322165
Topical riboflavin+UVA (CXL) produced measurable improvements in corneal optics (HOAs) — strong, direct ocular benefit.
- Patient subjective visual function after corneal collagen crosslinking for keratoconus and corneal ectasia
PubMed ID: 22342006
CXL with riboflavin+UVA reduced night-driving difficulty, glare and reading problems — clear symptomatic ocular benefit.
- Sequential topical riboflavin with or without ultraviolet a radiation with delayed intracorneal ring segment insertion for keratoconus
PubMed ID: 22265143
Comparative trial with riboflavin-only drops and CXL showed visual/topographic improvement overall but confounded by ring insertion; still ocular-relevant.
- Effect of topographic cone location on outcomes of corneal collagen cross-linking for keratoconus and corneal ectasia
PubMed ID: 22692521
Topical riboflavin + UV corneal cross‑linking produced clinically significant corneal flattening and vision improvement (direct, high relevance to eyes).
- Topography-guided hyperopic LASIK with and without high irradiance collagen cross-linking: initial comparative clinical findings in a contralateral eye study of 34 consecutive patients
PubMed ID: 23447898
Intrastromal riboflavin + UV during LASIK reduced long‑term regression and improved UDVA (strong clinical eye benefit).
- Morphological modification of the cornea after standard and transepithelial corneal cross-linking as imaged by anterior segment optical coherence tomography and laser scanning in vivo confocal microscopy
PubMed ID: 23538618
Traditional corneal CXL (riboflavin + UV) caused marked anterior stromal changes vs transepithelial technique (procedural/eye relevance).
- Characteristics influencing outcomes of corneal collagen crosslinking for keratoconus and ectasia: implications for patient selection
PubMed ID: 23889865
Study identifies predictors of greater improvement after CXL (riboflavin used), supporting procedural eye outcomes.
- Evaluation of corneal changes after conventional versus accelerated corneal cross-linking: a randomized controlled trial
PubMed ID: 25437483
RCT comparing accelerated vs conventional riboflavin‑UVA CXL found similar short‑term visual and keratometric improvements—supports eye health application.
- A randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus: three-year results
PubMed ID: 24393351
High‑quality RCT showing topical riboflavin‑UVA corneal cross‑linking halted keratoconus progression and improved vision over 3 years—direct strong evidence for ocular benefit.
- Transepithelial corneal collagen crosslinking for keratoconus: six-month results
PubMed ID: 25465683
Transepithelial riboflavin/UVA CXL produced statistically significant improvements in corneal curvature and corrected vision at 6 months.
- Effects of corneal cross-linking on ocular response analyzer waveform-derived variables in keratoconus and postrefractive surgery ectasia
PubMed ID: 25365551
Objective biomechanical ORA changes after riboflavin/UVA CXL indicate modest stiffening consistent with improved corneal integrity.
- Collagen cross-linking in keratoconus in Asian eyes: visual, refractive and confocal microscopy outcomes in a prospective randomized controlled trial
PubMed ID: 25708282
Sham‑controlled trial showed improved UDVA and flattened keratometry after riboflavin‑mediated CXL — direct ocular benefit.
- Treatment Effect and Corneal Light Scattering With 2 Corneal Cross-linking Protocols: A Randomized Clinical Trial
PubMed ID: 26312777
Randomized trial showing CXL‑related changes in corneal densitometry and shape—direct evidence tying riboflavin‑assisted CXL to corneal structural effects.
- Short-term comparison of accelerated and standard methods of corneal collagen crosslinking
PubMed ID: 25804580
Prospective randomized study: accelerated vs standard riboflavin‑UV crosslinking gave comparable short‑term vision/keratometry outcomes — substantive ocular relevance.
- Transepithelial Versus Epithelium-Off Corneal Collagen Cross-Linking for Progressive Keratoconus: A Prospective Randomized Controlled Trial
PubMed ID: 26266436
Large randomized trial: epi‑off riboflavin‑CXL halted keratoconus progression more effectively than transepithelial — strong direct ocular benefit.
- Combined laser in situ keratomileusis and prophylactic high-fluence corneal collagen crosslinking for high myopia: two-year safety and efficacy
PubMed ID: 26287881
Adding high‑fluence riboflavin/UV CXL to LASIK improved refractive stability and keratometry over 2 years — supports corneal stability and vision outcomes.
- Sequential Intracorneal Ring Segment Implantation and Corneal Transepithelial Collagen Cross-Linking in Keratoconus
PubMed ID: 26356750
Small RCT: transepithelial CXL added to intracorneal ring surgery improved spherical correction and vision — ocular benefit though small sample.
- Ultraviolet A/riboflavin collagen cross-linking for treatment of moderate bacterial corneal ulcers
PubMed ID: 25710507
Randomized trial showed adjunct UV‑A/riboflavin accelerated healing and reduced infiltrate area in bacterial corneal ulcers — clear ocular benefit for infection healing.
- Epithelium-off versus transepithelial corneal collagen crosslinking for progressive corneal ectasia: a randomised and controlled trial
PubMed ID: 27388250
24‑month RCT: epithelium‑off riboflavin‑CXL flattened cornea more than transepithelial — strong ocular outcome.
- Standard corneal collagen crosslinking versus transepithelial iontophoresis-assisted corneal crosslinking, 24 months follow-up: randomized control trial
PubMed ID: 27040458
Large randomized comparison: standard (epi‑off) CXL produced deeper stromal effect and greater corneal flattening than iontophoresis (epi‑on) over 2 years—strong eye relevance.
- Intraoperative corneal thickness change and clinical outcomes after corneal collagen crosslinking: Standard crosslinking versus hypotonic riboflavin
PubMed ID: 27113884
Using hypotonic riboflavin reduced intraoperative corneal thinning during CXL—procedural improvement with riboflavin formulation relevance.
- Randomized Controlled Trial Comparing Transepithelial Corneal Cross-linking Using Iontophoresis with the Dresden Protocol in Progressive Keratoconus
PubMed ID: 28283279
Iontophoresis‑assisted riboflavin CXL improved vision and stabilized keratoconus but with slightly less flattening than standard CXL—relevant ophthalmic data.
- United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment
PubMed ID: 28495149
Randomized trial: riboflavin+UVA corneal crosslinking produced meaningful reductions in corneal steepness and improved vision vs control—direct, high‑quality ocular benefit.
- Prospective Randomized Trial of Corneal Cross-linking Riboflavin Dosing Frequencies for Treatment of Keratoconus and Corneal Ectasia
PubMed ID: 29203068
Large equivalence RCT: different riboflavin dosing intervals produced equivalent corneal flattening and safety—supports riboflavin's role in effective CXL.
- U.S. Multicenter Clinical Trial of Corneal Collagen Crosslinking for Treatment of Corneal Ectasia after Refractive Surgery
PubMed ID: 28655538
Large multicenter randomized trial in post‑refractive ectasia: riboflavin+UVA improved keratometry and visual acuity vs riboflavin alone—strong direct eye health evidence.
- Transepithelial corneal crosslinking for keratoconus
PubMed ID: 29703286
Transepithelial CXL using riboflavin produced corneal flattening and UDVA improvement at 1 year — direct topical riboflavin effect.
- Prospective, randomized contralateral eye study of accelerated and conventional corneal cross-linking in pediatric keratoconus
PubMed ID: 29564806
Riboflavin+UVA CXL (riboflavin as photosensitizer) improved vision and corneal steepness in pediatric keratoconus up to 3 years — clear ocular benefit.
- Standard and accelerated corneal cross-linking long-term results: A randomized clinical trial
PubMed ID: 30943777
Four‑year results show standard riboflavin+UVA CXL produced greater corneal flattening than accelerated CXL — durable eye benefit where riboflavin is essential to the procedure.
- Corneal collagen cross-linking with and without simultaneous intrastromal corneal ring segment implantation: One-year pilot study
PubMed ID: 31707858
Duplicate entry confirmation: topical riboflavin used in combined CXL + ring implantation, clinically relevant to eye health.
- Randomized Study of Collagen Cross-Linking With Conventional Versus Accelerated UVA Irradiation Using Riboflavin With Hydroxypropyl Methylcellulose: Two-Year Results
PubMed ID: 30365412
Riboflavin‑based CXL (methylcellulose‑riboflavin) produced similar 2‑year vision/Kmax improvements—direct ocular application of B2.
- Corneal crosslinking and intracorneal ring segments for keratoconus: A randomized study of concurrent versus sequential surgery
PubMed ID: 30928252
Adjunctive riboflavin CXL plus intracorneal rings produced substantial corneal flattening and VA gains.
- Randomized Control Trial on the Effectiveness of Collagen Cross-linking on Bullous Keratopathy
PubMed ID: 33017120
CXL with riboflavin produced transient corneal thinning and no durable pain/vision benefits in this short study.
- Corneal Haze After Transepithelial Collagen Cross-linking for Keratoconus: A Scheimpflug Densitometry Analysis
PubMed ID: 32282356
Transepithelial CXL with riboflavin caused transient corneal haze that resolved with no lasting visual impact.
- Corneal higher-order aberrations after crosslinking and intrastromal corneal ring segments for keratoconus
PubMed ID: 32282434
Intrastromal ring segments combined with riboflavin CXL improved corneal HOAs (ocular structural benefit).
- Effect of Corneal Cross-linking versus Standard Care on Keratoconus Progression in Young Patients: The KERALINK Randomized Controlled Trial
PubMed ID: 33892046
High‑quality randomized trial: riboflavin‑UVA crosslinking strongly halted keratoconus progression and improved vision — direct, strong eye‑health evidence.
- Systemic supplemental oxygen therapy during accelerated corneal crosslinking for progressive keratoconus: randomized clinical trial
PubMed ID: 33252568
Supplemental oxygen during CXL with riboflavin increased corneal flattening and biomechanical resistance — meaningful procedural eye benefit.
- The efficiency and safety of oxygen-supplemented accelerated transepithelial corneal cross-linking
PubMed ID: 33876334
Oxygen‑supplemented transepithelial CXL produced greater flattening and deeper effect with no endothelial harm — strong eye relevance.
- Cool Crosslinking: Riboflavin at 4°C for Pain Management After Crosslinking for Keratoconus Patients, A Randomized Clinical Trial
PubMed ID: 33264161
Cold riboflavin application notably reduced post‑CXL pain — practical procedural improvement in eye care.
Nutrition source (40)
- A Community-Based Early Childhood Development Center Platform Promoting Diversified Diets and Food Production Increases the Mean Probability of Adequacy of Intake of Preschoolers in Malawi: A Cluster Randomized Trial
PubMed ID: 31616933
Preschool intervention improved probability of adequate riboflavin intake at population level, supporting blood‑relevant micronutrient status.
- Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects
PubMed ID: 16391577
Randomized trial showed riboflavin altered folic acid's effect on homocysteine and changed liver enzyme responses — direct evidence of B2 interacting with folate metabolism.
- B-vitamin status and concentrations of homocysteine in Austrian omnivores, vegetarians and vegans
PubMed ID: 16988496
Observational: riboflavin deficiency in vegans associated with elevated homocysteine and low B12 — indicates riboflavin's role in B‑vitamin interactions.
- Impact of the MTHFR C677T polymorphism on one-carbon metabolites: Evidence from a randomised trial of riboflavin supplementation
PubMed ID: 32330571
Riboflavin supplementation corrected specific one‑carbon metabolic perturbations linked to MTHFR genotype—strong mechanistic link to B‑vitamin interdependence.
- Assessment of vitamin A, vitamin B(2), vitamin B(12), vitamin K, folate, and choline status following 4 months of multinutrient supplementation in healthy vegans: a randomised, double-blind, placebo-controlled trial
PubMed ID: 41417236
Multinutrient supplement in vegans improved B12 biomarkers and attenuated riboflavin decline — direct evidence of interplay between B vitamins in supplementation.
- Lack of association between indices of vitamin B1, B2, and B6 status and exercise-induced blood lactate in young adults
PubMed ID: 8508194
B‑complex supplementation improved riboflavin enzyme markers, showing interplay within B‑vitamin regimen.
- Effect of a fortified maize-meal porridge on anemia, micronutrient status, and motor development of infants
PubMed ID: 16280435
Fortified maize with multiple micronutrients raised hemoglobin and serum ferritin and reduced anemia prevalence in infants—riboflavin was a component of the fortification.
- Effects of multivitamin/mineral supplementation on plasma levels of nutrients. Report No. 4 of the Italian-American clinical trial of nutritional supplements and age-related cataract
PubMed ID: 19636163
Long‑term multivitamin raised riboflavin and other vitamins in older adults—demonstrates co‑improvement of B‑vitamin status in a combined supplement context.
- A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
PubMed ID: 31408467
B‑vitamin drink containing riboflavin substantially lowered plasma homocysteine — a direct, clinically meaningful hematometabolic effect.
- Postoperative Vitamin Profile after Receiving a Novel Peripheral Parenteral Nutrition Solution: Multicenter Randomized Controlled Phase III Trial
PubMed ID: 35439754
Multivitamin PPN (including riboflavin) preserved multiple B‑vitamin blood levels postoperatively — supports co‑maintenance of other B vitamins in clinical nutrition.
- Nutritional efficacy of a fortified weaning rusk in a rural area near Beijing
PubMed ID: 8460605
Fortified weaning food preserved hemoglobin in infants; intervention included riboflavin among other nutrients, with modest riboflavin status improvement.
- Impact of a multiple-micronutrient food supplement on the nutritional status of schoolchildren
PubMed ID: 17542110
Food‑based multiple‑micronutrient supplement (including riboflavin) improved hemoglobin in schoolchildren over 9 months — supports RBC status though multi‑nutrient.
- Trial using multiple micronutrient food supplement and its effect on cognition
PubMed ID: 18716734
School food fortified with many micronutrients (including B2) improved hemoglobin and hematologic indices; effect attributable to multi‑micronutrient regimen rather than B2 alone but evidence of improved RBC outcomes.
- Effects of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on preschool children in a suburb of Chongqing, China
PubMed ID: 19155581
Preschoolers receiving multiple micronutrients (including riboflavin) had improved hemoglobin and iron mobilization — strong hematologic improvements though not isolated to B2.
- [Effects of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on iron metabolic homeostasis]
PubMed ID: 22336361
Fortified foods including riboflavin and other micronutrients improved iron-status markers in preschool children—supports healthier blood parameters though multi-nutrient.
- Three-month B vitamin supplementation in pre-school children affects folate status and homocysteine, but not cognitive performance
PubMed ID: 24481688
B‑complex supplementation (including B2) raised folate and lowered homocysteine in preschoolers — demonstrates interaction/co‑supplementation effects among B vitamins.
- Effect of low-dosage vitamin A and riboflavin on iron-folate supplementation in anaemic pregnant women
PubMed ID: 12495257
In anemic pregnant women, adding riboflavin to iron‑folate tended to further improve hemoglobin gain—direct trial evidence of B2 supporting hemoglobin response (modest effect).
- A micronutrient-fortified beverage prevents iron deficiency, reduces anemia and improves the hemoglobin concentration of pregnant Tanzanian women
PubMed ID: 12730420
Randomized trial in pregnant women: multi‑micronutrient beverage (including riboflavin) significantly raised hemoglobin and ferritin and greatly reduced anemia risk—strong support for the intervention's blood benefits.
- Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study)
PubMed ID: 17932361
Riboflavin supplementation improved riboflavin biomarkers and modulated mucosal folate response to folic acid, with genotype‑dependent interactions — strong cross‑B vitamin support.
- Retinol and riboflavin supplementation decreases the prevalence of anemia in Chinese pregnant women taking iron and folic Acid supplements
PubMed ID: 18806105
Adding retinol+riboflavin to iron+folic acid in anemic pregnant women further reduced anemia prevalence, supporting a role in blood/hematologic status though riboflavin was part of a combo.
- Impact of a multiple-micronutrient fortified salt on the nutritional status and memory of schoolchildren
PubMed ID: 20533221
Fortified salt trial produced meaningful hemoglobin and iron status improvements in children; riboflavin included among active micronutrients.
- Supplementation of iron alone and combined with vitamins improves haematological status, erythrocyte membrane fluidity and oxidative stress in anaemic pregnant women
PubMed ID: 20615267
Iron plus vitamins including riboflavin raised hemoglobin markedly and improved erythrocyte membrane/oxidative markers in anemic pregnant women—strong hematologic benefit from the multi‑nutrient regimen.
- Long-term intermittent multiple micronutrient supplementation enhances hemoglobin and micronutrient status more than iron + folic acid supplementation in Bangladeshi rural adolescent girls with nutritional anemia
PubMed ID: 20702745
Year‑long intermittent MMN that included riboflavin improved riboflavin status and in some analyses increased hemoglobin versus IFA, supporting RBC/hematologic benefit of the MMN formulation.
- [Bioavailability of natural versus synthetic B vitamins and their effects on metabolic processes]
PubMed ID: 32189314
Natural and synthetic B‑vitamin complexes raised blood B2 similarly and altered related metabolic markers.
- Randomized Trial Comparing Consumption of Military Rations to Usual Intake for 21 Consecutive Days: Nutrient Adequacy and Indicators of Health Status
PubMed ID: 32828737
Military rations increased multiple B‑vitamin intakes including riboflavin, showing concurrent improvement of B‑vitamin status.
- A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels
PubMed ID: 31915511
B‑complex supplementation decreased total homocysteine and raised serum riboflavin — relevant to blood metabolic health.
- [Mechanism and prevention of hemolysis in jaundiced infants in phototherapy]
PubMed ID: 7994648
Oral riboflavin in jaundiced infants reduced hemoglobin loss during phototherapy and hastened recovery — direct blood‑related benefit.
- Riboflavin and vitamin B-6 intakes and status and biochemical response to riboflavin supplementation in free-living elderly people
PubMed ID: 9701198
Low-dose riboflavin corrected EGRAC and improved plasma PLP (vitamin B6) in deficient elderly—strong evidence that riboflavin supports B6 status.
- The effects of a multivitamin/mineral supplement on micronutrient status, antioxidant capacity and cytokine production in healthy older adults consuming a fortified diet
PubMed ID: 11022875
Multivitamin improved riboflavin activity coefficient and increased plasma levels of multiple vitamins (including PLP), indicating interplay among B vitamins.
- Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism
PubMed ID: 16380544
Randomized riboflavin supplementation produced large genotype‑specific homocysteine reductions (MTHFR TT), demonstrating direct biochemical support of folate/B12 pathways.
- Correcting a marginal riboflavin deficiency improves hematologic status in young women in the United Kingdom (RIBOFEM)
PubMed ID: 21525198
Randomized trial: riboflavin supplementation (2–4 mg) improved EGRAC (riboflavin status) and increased hemoglobin in young women with marginal deficiency—direct, high-quality evidence for blood/hematologic benefit.
- Effect of micronutrient pack on micronutrient status and antioxidant capacities among institutional older adults in Shanghai, China
PubMed ID: 31464392
Micronutrient pack in older adults increased B2 and B12, demonstrating co‑improvement of B‑vitamin status.
- Multiple micronutrient supplementation improves anemia, micronutrient nutrient status, and growth of Vietnamese infants: double-blind, randomized, placebo-controlled trial
PubMed ID: 15735111
Daily multiple micronutrients improved infant hemoglobin and ferritin substantially versus controls—clear blood benefits from the combined supplement that included riboflavin.
- Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, growth, and morbidity of Peruvian infants
PubMed ID: 15735109
Daily multi‑micronutrient supplementation best reduced anemia and preserved iron stores in Peruvian infants—riboflavin included in the effective formulation.
- Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, and growth in South African infants
PubMed ID: 15735110
Infants receiving daily multiple micronutrients (including riboflavin) had improved anemia and iron-related markers, indicating benefit to blood health as part of MMN.
- Fortified breakfast cereal consumed daily for 12 wk leads to a significant improvement in micronutrient intake and micronutrient status in adolescent girls: a randomised controlled trial
PubMed ID: 27418034
Fortified cereal increased riboflavin intake/status—improved riboflavin status can influence metabolism of other B vitamins, though this study focused on B2 biomarkers.
- Micronutrient-Fortified Milk and Academic Performance among Chinese Middle School Students: A Cluster-Randomized Controlled Trial
PubMed ID: 28257107
Fortified milk increased riboflavin status and substantially reduced iron deficiency in children—directly relevant to RBC health/iron status (multi‑nutrient intervention).
- Antiretroviral therapy provided to HIV-infected Malawian women in a randomized trial diminishes the positive effects of lipid-based nutrient supplements on breast-milk B vitamins
PubMed ID: 26537941
LNS raised most B vitamins in breast milk (including riboflavin), showing interplay and co‑support among B vitamins in supplementation.
- Chronically increased vitamin intake and vitamin status of healthy men
PubMed ID: 8467105
Chronic vitamin intake increased urinary riboflavin excretion and plasma vitamin concentrations—shows interrelated B‑vitamin status changes.
- Effect of Plasmodium inactivation in whole blood on the incidence of blood transfusion-transmitted malaria in endemic regions: the African Investigation of the Mirasol System (AIMS) randomised controlled trial
PubMed ID: 27116282
Clinical study: riboflavin pathogen‑reduction of donor blood greatly lowered transfusion‑transmitted malaria without increasing adverse events—strong blood‑safety benefit.
Cell health (25)
- Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy
PubMed ID: 18377693
CoQ10+riboflavin+niacin in breast cancer patients increased DNA repair markers and altered tumor‑related methylation; riboflavin was a component plausibly supporting repair processes but attribution is shared.
- Corneal collagen crosslinking for keratoconus and corneal ectasia: One-year results
PubMed ID: 21183110
CXL with riboflavin induces corneal crosslinking and structural 'repair' of ectatic cornea—procedure‑specific cellular/tissue remodeling.
- Higher-order aberrations after corneal collagen crosslinking for keratoconus and corneal ectasia
PubMed ID: 22322165
Corneal collagen crosslinking (riboflavin+UVA) reduces higher-order aberrations and stabilizes corneal structure — tissue-protective procedural effect.
- Patient subjective visual function after corneal collagen crosslinking for keratoconus and corneal ectasia
PubMed ID: 22342006
CXL (riboflavin+UVA) improved subjective visual symptoms, reflecting corneal tissue protection/functional preservation.
- Standard corneal collagen crosslinking versus transepithelial iontophoresis-assisted corneal crosslinking, 24 months follow-up: randomized control trial
PubMed ID: 27040458
Standard CXL created deeper demarcation line and greater flattening than iontophoresis CXL—supports more pronounced tissue crosslinking/repair with standard riboflavin protocol.
- Treatment Effect and Corneal Light Scattering With 2 Corneal Cross-linking Protocols: A Randomized Clinical Trial
PubMed ID: 26312777
CXL increased corneal light scatter and related to flattening—structural tissue changes consistent with crosslinking repair processes.
- Transepithelial Versus Epithelium-Off Corneal Collagen Cross-Linking for Progressive Keratoconus: A Prospective Randomized Controlled Trial
PubMed ID: 26266436
Epi‑off riboflavin+UVA CXL halted keratoconus progression and produced meaningful corneal remodeling—direct evidence of tissue stabilization/repair.
- Ultraviolet A/riboflavin collagen cross-linking for treatment of moderate bacterial corneal ulcers
PubMed ID: 25710507
Riboflavin/UVA CXL accelerated epithelial healing and reduced infiltrate size in corneal infection — direct tissue‑repair effect locally.
- [Effect of early correction of energy and free-radical homeostasis on the clinical-morphological presentation of cerebral infarction]
PubMed ID: 20823824
Early antioxidant therapy including riboflavin improved oxidative markers after acute ischemic stroke—suggests cell-protective effects, but interventions combined.
- [Efficacy of cytoflavin in the treatment of burns patients with toxic and post-hypoxic encephalopathy]
PubMed ID: 21183910
Cytoflavin (contains riboflavin) reduced lipid peroxidation and improved oxidative markers in burn encephalopathy—direct evidence of cellular protection, though multi-component.
- Effect of micronutrient pack on micronutrient status and antioxidant capacities among institutional older adults in Shanghai, China
PubMed ID: 31464392
Micronutrient supplementation increased serum B2 and improved oxidative stress marker (MDA), supporting cellular repair processes.
- Oral Riboflavin to Assess Ureteral Patency During Cystoscopy: A Randomized Clinical Trial
PubMed ID: 30633139
Oral riboflavin given before cystoscopy colored urine and improved visualization of ureteric jets, directly affecting urinary mucosal assessment.
- Long-term Results of an Accelerated Corneal Cross-linking Protocol (18 mW/cm2) for the Treatment of Progressive Keratoconus
PubMed ID: 26314662
Standard protocol produced more corneal flattening than accelerated protocol, consistent with greater structural/repair effect.
- Transepithelial versus epithelium-off corneal cross-linking for the treatment of progressive keratoconus: a randomized controlled trial
PubMed ID: 25703475
Epi‑off CXL produced greater corneal flattening vs transepithelial—supports stronger stromal repair effect with riboflavin‑assisted epi‑off protocol.
- [Efficacy of antioxidant energocorreсtion in brain infarction (results of a multicenter randomized trial)]
PubMed ID: 25591516
Same multicenter stroke data showing ≈25–29% reduction in infarct volume with cytoflavin—evidence of cytoprotection (combination therapy).
- [Modern methods of energy homeostasis correction in elderly patients]
PubMed ID: 25946854
Cytoflavin reduced ischemic lesion volume after stroke (multi‑component product) indicating reduced cellular injury.
- [Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period]
PubMed ID: 22238957
After peritonitis, adding cytoflavin hastened antioxidant recovery and lowered peroxidation—supports cellular protection but multi-agent.
- [Positive effect of cytoflavin on metabolic status changes in patients with burn disorder]
PubMed ID: 21894767
Burn patient trial showed increased antioxidant enzyme activity and decreased oxidative markers with cytoflavin—supports cellular protection (multi-component).
- Effect of riboflavin-fortified salt nutrition intervention on esophageal squamous cell carcinoma in a high incidence area, China
PubMed ID: 19827881
Riboflavin-fortified salt improved EGRAC and reduced precancerous esophageal lesions in a large population intervention (direct riboflavin fortification).
- Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: a randomized controlled trial
PubMed ID: 16517955
Post‑stroke supplementation including B vitamins (riboflavin present) improved antioxidant capacity and lowered oxidative markers, supporting cell-protective effects.
- A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels
PubMed ID: 31915511
Natural B‑complex increased total antioxidant capacity (TAC), suggesting cellular oxidative protection linked to riboflavin status.
- Five-year results of a prospective, randomised, contralateral eye trial of corneal crosslinking for keratoconus
PubMed ID: 34117699
Five‑year contralateral RCT showed long‑term halting/reversal of keratoconus — tissue‑protective effect in cornea.
- Effect of Corneal Cross-linking versus Standard Care on Keratoconus Progression in Young Patients: The KERALINK Randomized Controlled Trial
PubMed ID: 33892046
CXL with riboflavin markedly reduced keratoconus progression — protects corneal tissue from further damage.
- Multiple micronutrient fortification of salt and its effect on cognition in Chennai school children
PubMed ID: 17704033
Fortified‑salt intervention in schools eradicated angular stomatitis (a classic B‑vitamin mucosal sign) in the supplemented group — clear clinical mucous‑membrane effect though multi‑nutrient.
- [Oxidative stress and combined antioxidant energy correction in the treatment of periodontitis]
PubMed ID: 21378714
Cytoflavin improved oxidative stress markers and periodontal outcomes—evidence of antioxidant/cell-protective effects though riboflavin is one of several agents.
Illness recovery (28)
- [Correction of energy homeostasis in the acute period of concomitant brain injury]
PubMed ID: 23994918
In brain‑injury patients, adding cytoflavin improved severity scores and shortened ventilation/hospital stay—evidence of improved recovery (combination therapy).
- [Modern methods of energy homeostasis correction in elderly patients]
PubMed ID: 25946854
Large randomized multicenter trial: cytoflavin reduced ischemic lesion size and improved neurologic/functional outcomes after stroke—strong evidence of improved recovery (product contains riboflavin).
- [Efficacy of antioxidant energocorreсtion in brain infarction (results of a multicenter randomized trial)]
PubMed ID: 25591516
Same multicenter data reporting ≈25–29% infarct volume reduction with cytoflavin and associated better recovery—supports resilience/recovery.
- [Clinical effectiveness of cytoflavin inclusion in intensive care of patients with combined traumatic brain injury]
PubMed ID: 25076759
Cytoflavin in severe TBI reduced organ dysfunction, infections and shortened ICU stay — indicates improved recovery/resilience though product is multi‑component.
- [Clinical and morphologic efficacy of a complex antioxidant and energy correction therapy of different duration in brain infarction: results of a multicenter randomized trial]
PubMed ID: 26356615
Cytoflavin adjunct in ischemic stroke reduced lesion volume and improved clinical outcomes — supports recovery but not riboflavin‑specific.
- [Performance evaluation of integrated cytoprotective therapy of different duration in patients with cerebral infarction]
PubMed ID: 25826870
Cytoflavin in cerebral infarction reduced ischemic volume and improved neurologic outcomes — consistent recovery/resilience benefit from multi‑agent regimen.
- [Cytoflavin efficacy in the treatment of disseminated encephalomyelitis in children]
PubMed ID: 29359722
Cytoflavin improved neurologic recovery in disseminated encephalomyelitis by day30—clinical recovery evidence though multi‑component.
- Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke
PubMed ID: 30014516
Riboflavin treatment in acute ischemic stroke reduced blood glutamate and trended to better neurological improvement — suggests benefit for acute recovery.
- Evaluation of corneal cross-linking as adjuvant therapy for the management of fungal keratitis
PubMed ID: 31041523
Riboflavin‑UVA CXL adjunct accelerated ulcer healing and reduced treatment burden in fungal keratitis — faster recovery in ocular infection.
- [The result of prospective randomized study CITADEL - the efficacy and safety of drug cytoflavin in postcovid rehabilitation]
PubMed ID: 34874654
Cytoflavin associated with improved fatigue and cognition during post‑COVID recovery — multi‑component but clinically relevant to resilience.
- [Improving the effectiveness of treatment of patients with post-stroke aphasia]
PubMed ID: 39575955
Cytoflavin adjunct improved aphasia recovery and reduced disability after stroke—supports a role in functional recovery (product contains riboflavin among other agents).
- [The effectiveness of Cytoflavin in the medical rehabilitation of elderly and senile patients]
PubMed ID: 39731767
Cytoflavin recipients in COVID‑19 rehab had better cognition, less fatigue and much greater walking distance—strong recovery/resilience signal though multi‑ingredient.
- [Results of the observational program CITOTREK (use of the drug CITOflavin in Tablets) in patients with tension headaches against the backgRound of asthenic syndromE taKing into account comorbidity]
PubMed ID: 41255326
Adding Cytoflavin to standard therapy substantially reduced headache frequency and severity—clinically meaningful improvement in symptomatic resilience (multi‑ingredient).
- [Pathogenetic and therapeutic approaches to the correction of neurocognitive disorders in patients with chronic brucellosis]
PubMed ID: 41524166
Cytoflavin infusion improved cognitive scores and quality of life in chronic brucellosis—supports improved resilience/recovery (small RCT; combination drug).
- Effects of vitamin-B complex supplementation on periodontal wound healing
PubMed ID: 16018750
After periodontal surgery, vitamin B‑complex (including riboflavin) produced better clinical attachment gains vs placebo—indicates a role in tissue recovery when given as part of B vitamins.
- United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment
PubMed ID: 28495149
CXL with riboflavin improved keratometry/vision vs control—evidence of durable structural/functional recovery in corneal disease.
- U.S. Multicenter Clinical Trial of Corneal Collagen Crosslinking for Treatment of Corneal Ectasia after Refractive Surgery
PubMed ID: 28655538
Riboflavin+UVA CXL improved corneal shape and vision in post‑refractive ectasia—supports structural recovery of cornea with riboflavin as essential component.
- Cool Crosslinking: Riboflavin at 4°C for Pain Management After Crosslinking for Keratoconus Patients, A Randomized Clinical Trial
PubMed ID: 33264161
Using cold riboflavin in CXL substantially reduced postoperative pain and symptoms — facilitates recovery after eye surgery.
- [Efficiency of intensive care with cytoflavin in patients of advanced age in combined traumatic brain injury]
PubMed ID: 25827011
Elderly TBI patients had earlier consciousness recovery and fewer complications with cytoflavin—recovery‑focused outcome.
- Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: a randomized controlled trial
PubMed ID: 16517955
After acute stroke, antioxidant and B‑vitamin (including riboflavin) interventions improved antioxidant and inflammatory biomarkers—consistent with enhanced biochemical recovery/resilience.
- [Mechanism and prevention of hemolysis in jaundiced infants in phototherapy]
PubMed ID: 7994648
In jaundiced infants, oral riboflavin during phototherapy reduced hemolysis and sped jaundice resolution — clear recovery benefit in this setting.
- Riboflavin status in acute ischaemic stroke
PubMed ID: 17299470
Rapid correction of riboflavin deficiency in stroke patients suggests restoring riboflavin may support physiological recovery processes in neurologic illness.
- [Efficacy of cytoflavin in patients in the acute ischemic stroke]
PubMed ID: 21311484
Cytoflavin showed trends toward less brain damage and better function after ischemic stroke—supports recovery/resilience though multi-component.
- [Efficacy of cytoflavin in the treatment of burns patients with toxic and post-hypoxic encephalopathy]
PubMed ID: 21183910
Burn encephalopathy patients receiving cytoflavin had improved oxidative markers, MOD index and cognitive scores—supports recovery.
- [Effect of early correction of energy and free-radical homeostasis on the clinical-morphological presentation of cerebral infarction]
PubMed ID: 20823824
Early antioxidant therapy including riboflavin improved imaging/neurologic outcomes after acute ischemic stroke—evidence of improved recovery (multi-agent).
- [Cytoflavin in the complex treatment of neuroinfections in children]
PubMed ID: 22027666
In children with meningitis/encephalitis, adding cytoflavin shortened recovery and reduced long-term problems—supportive of resilience, multi-component.
- [Correction of nonspecific damages in acute poisoning of substance from the group of opiate drug in patients in critical condition]
PubMed ID: 22329170
Metabolic corrector with riboflavin reduced coma time, pulmonary complications, and deaths in severe opioid poisoning—supports improved clinical recovery (multi-agent).
- [Pharmacological correction of free radical disturbances and endotoxicosis in patients with diffuse peritonitis at the postoperative period]
PubMed ID: 22238957
Cytoflavin improved antioxidant status and shortened recovery/ventilation time in postoperative peritonitis—supports recovery (multi-component).
Nerve health (27)
- [EFFECTIVENESS OF CYTOFLAVIN FOR THE CORRECTION OF COGNITIVE IMPAIRMENTS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS]
PubMed ID: 27017701
Cytoflavin (contains riboflavin) improved cognitive scores and increased BDNF in people with type 2 diabetes—relevant to brain/nervous system function though multi‑component.
- [Efficacy of antioxidant energocorreсtion in brain infarction (results of a multicenter randomized trial)]
PubMed ID: 25591516
Same stroke trial reporting reduced infarct volume and better neurologic recovery with cytoflavin.
- [Modern methods of energy homeostasis correction in elderly patients]
PubMed ID: 25946854
Large stroke trial with cytoflavin improved neurologic and functional outcomes, implying central nervous system benefit (combination therapy).
- [Rationale of application of the drug Cytoflavin in complex treatment of patients with diabetic foot syndrome with mediacalcification arteries]
PubMed ID: 25589316
Small randomized study in diabetic foot reported better nerve function signs when cytoflavin (includes riboflavin) was added—directly relevant to peripheral nerve health.
- [Possibilities of treatment of multiple sclerosis exacerbations without corticosteroids: a role of metabolic and antioxidant therapy]
PubMed ID: 21350423
In MS relapse, cytoflavin reduced steroid need and improved neurological scores—supports nervous system benefit but multi-component.
- [Effect of early correction of energy and free-radical homeostasis on the clinical-morphological presentation of cerebral infarction]
PubMed ID: 20823824
Early cytoflavin therapy after acute ischemic stroke improved neurologic outcomes and antioxidant markers—supports neural recovery but is multi-component.
- [Efficacy of cytoflavin in patients in the acute ischemic stroke]
PubMed ID: 21311484
Multi-agent cytoflavin (contains riboflavin) showed trends toward less brain damage and better function after ischemic stroke—suggests potential neural benefit though attribution to riboflavin alone is uncertain.
- Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial
PubMed ID: 9484373
High‑dose riboflavin (400 mg) RCT produced large, statistically significant reductions in migraine frequency and headache days, a neurological benefit.
- Riboflavin status in acute ischaemic stroke
PubMed ID: 17299470
High prevalence of riboflavin deficiency among acute stroke patients and prompt biochemical correction with 5 mg/day indicates relevance to nervous‑system metabolic status.
- Biochemical indices and neuromuscular function tests in rural Gambian schoolchildren given a riboflavin, or multivitamin plus iron, supplement
PubMed ID: 7986790
In riboflavin‑deficient Gambian children, supplementation corrected biochemical deficiency and improved an objective neuromuscular (arm‑tremor) test in boys.
- Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial
PubMed ID: 26678525
Higher riboflavin status in formula‑fed infants associated with better gross motor scores at 6 months — developmental nervous system relevance.
- Effect of B vitamins-fortified foods on primary school children in Beijing
PubMed ID: 16883966
Riboflavin‑fortified foods improved riboflavin biomarkers and a school performance/cognitive index, supporting cognitive/nervous system function in children.
- Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
PubMed ID: 25916335
Migraine reduction in pain intensity and HIT‑6 with a supplement containing high‑dose riboflavin supports a neurological/mitochondrial effect (multi‑component).
- Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation
PubMed ID: 21496936
Four months of micronutrient supplementation (including riboflavin) markedly improved neuropathy symptom scores—supports symptomatic nervous‑system benefit of the supplement mix.
- Treatment of alcoholic polyneuropathy with vitamin B complex: a randomised controlled trial
PubMed ID: 16926172
Large RCT of B‑complex (including riboflavin) in alcoholic polyneuropathy produced significant symptomatic and objective improvements — strong clinical nervous‑system evidence (complex therapy).
- Clinical usefulness of nutraceutics with acetyl-L-carnitine, α-lipoic acid, phosphatidylserine, curcumin, C, E and B-group vitamins in patients awaiting for carpal tunnel release during COVID-19 pandemic: a randomized controlled open label prospective study
PubMed ID: 37366197
Multi‑nutrient supplement including B‑vitamins reduced symptoms/pain in carpal tunnel patients — relevant to peripheral nerve symptom improvement though B2-specific attribution limited.
- [Clinical and morphologic efficacy of a complex antioxidant and energy correction therapy of different duration in brain infarction: results of a multicenter randomized trial]
PubMed ID: 26356615
Cytoflavin reduced ischemic lesion size and improved clinical recovery after stroke—pertinent to nervous system outcomes but not riboflavin‑specific.
- [Pathogenetic and therapeutic approaches to the correction of neurocognitive disorders in patients with chronic brucellosis]
PubMed ID: 41524166
Cytoflavin infusions in chronic brucellosis improved cognitive scores and neurological deficit severity, implying neural benefit (multi‑component intervention).
- Impact of Vitamin B1 and Vitamin B2 Supplementation on Anxiety, Stress, and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 40507089
B1+B2 supplementation reduced perceived stress and improved sleep/daytime sleepiness — beneficial for nervous system function and resilience.
- [The effectiveness of Cytoflavin in the medical rehabilitation of elderly and senile patients]
PubMed ID: 39731767
In elderly COVID‑19 pneumonia rehab, Cytoflavin recipients had better cognitive function and exercise tolerance—consistent with neural/functional recovery (multi‑ingredient).
- [Improving the effectiveness of treatment of patients with post-stroke aphasia]
PubMed ID: 39575955
Cytoflavin added to post‑stroke speech rehab improved aphasia and disability—suggests neurofunctional benefit though the product contains multiple active ingredients.
- [Efficacy and safety of Cytoflavin in the treatment of diabetic polyneuropathy: results of a multicenter, double-blind, placebo-controlled, randomized CYLINDER study]
PubMed ID: 37315248
Cytoflavin (contains riboflavin) improved neuropathic symptom scores in diabetic polyneuropathy versus placebo — notable nervous-system clinical benefit albeit multi‑component.
- Efficacy and safety of the combined metabolic medication, containing inosine, nicotinamide, riboflavin and succinic acid, for the treatment of diabetic neuropathy: a multicenter randomized, double-blind, placebo-controlled parallel group clinical trial (CYLINDER)
PubMed ID: 35680173
Randomized trial of a metabolic drug (inosine, nicotinamide, riboflavin, succinic acid) produced substantial neuropathic symptom reductions — strong, but multicomponent.
- Early predictive blood markers of hemorrhagic stroke - influence of cytoflavin therapy
PubMed ID: 32910863
Cytoflavin (includes riboflavin) added to standard care in hemorrhagic stroke associated with stabilized markers and lower in‑hospital deaths.
- Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke
PubMed ID: 30014516
IV/oral riboflavin in acute ischemic stroke reduced blood glutamate and showed a borderline better neurologic improvement — direct neuro outcome.
- [Cytoflavin efficacy in the treatment of disseminated encephalomyelitis in children]
PubMed ID: 29359722
Pediatric disseminated encephalomyelitis trial: cytoflavin produced faster and more complete neurologic recovery by day 30; riboflavin is one component so attribution is moderate.
- [An effect of cytoprotective therapy on stress resistance and compensatory abilities of patients with chronic cerebral ischemia]
PubMed ID: 26978497
Study in chronic cerebral ischemia found cytoflavin improved 1‑year clinical outcomes—relevant to brain health though multi‑ingredient.
Energy & Fatigue (23)
- Impact of Vitamin B1 and Vitamin B2 Supplementation on Anxiety, Stress, and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 40507089
B1+B2 supplementation reduced daytime sleepiness (ESS) and improved sleep quality — direct patient‑reported reduction in tiredness (combination product).
- Impact of the MTHFR C677T polymorphism on one-carbon metabolites: Evidence from a randomised trial of riboflavin supplementation
PubMed ID: 32330571
Riboflavin supplementation changed one‑carbon metabolic markers relevant to cellular energetics in MTHFR TT subjects.
- Assessment of vitamin A, vitamin B(2), vitamin B(12), vitamin K, folate, and choline status following 4 months of multinutrient supplementation in healthy vegans: a randomised, double-blind, placebo-controlled trial
PubMed ID: 41417236
Supplement attenuated decline in FAD (riboflavin vitamer); FAD is essential for numerous dehydrogenases in energy metabolism—strong biomarker‑level support for improved conversion capacity (multinutrient).
- Effect of a fortified maize-meal porridge on anemia, micronutrient status, and motor development of infants
PubMed ID: 16280435
Fortified maize (with riboflavin among other nutrients) raised hemoglobin and reduced anemia prevalence in infants—biologically linked to less fatigue; attribution to riboflavin alone not possible.
- A micronutrient-fortified beverage prevents iron deficiency, reduces anemia and improves the hemoglobin concentration of pregnant Tanzanian women
PubMed ID: 12730420
Pregnant women receiving a micronutrient beverage (including riboflavin) had increased hemoglobin and ferritin—improvements in iron status are strongly linked to reduced tiredness, though effects are from the full multi‑nutrient intervention.
- [Improving the effectiveness of treatment of patients with post-stroke aphasia]
PubMed ID: 39575955
Cytoflavin added to post‑stroke therapy associated with lower disability and better recovery, including less fatigue—multi‑ingredient limits specific attribution to riboflavin.
- [The effectiveness of Cytoflavin in the medical rehabilitation of elderly and senile patients]
PubMed ID: 39731767
Cytoflavin in elderly COVID‑19 rehab produced large decreases in multidimensional fatigue scores—strong clinical effect though multi‑component drug.
- Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study)
PubMed ID: 17932361
RCT of riboflavin improved biochemical markers of riboflavin status and influenced tissue folate handling—demonstrates functional effects of riboflavin in one‑carbon and related metabolism important for energy/cofactor reactions.
- Retinol and riboflavin supplementation decreases the prevalence of anemia in Chinese pregnant women taking iron and folic Acid supplements
PubMed ID: 18806105
In anemic pregnant women adding retinol+riboflavin to iron+folic acid further reduced anemia prevalence—improvements in anemia can reduce tiredness, though riboflavin was part of a combo.
- [Bioavailability of natural versus synthetic B vitamins and their effects on metabolic processes]
PubMed ID: 32189314
B‑vitamin complexes raised serum B2 and altered metabolic markers; riboflavin is a known cofactor in energy metabolism.
- A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial
PubMed ID: 37786445
Vitamin B complex (includes riboflavin) markedly increased time to exhaustion and lowered exercise lactate/ammonia — strong functional energy/performance evidence, though multi‑ingredient.
- Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation
PubMed ID: 12194936
Low‑dose riboflavin produced large increases in plasma riboflavin and erythrocyte FMN (key cofactors for energy metabolism) — strong biochemical evidence.
- Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism
PubMed ID: 16380544
Direct biochemical evidence: riboflavin supplementation markedly improved erythrocyte flavoprotein activation and substantially lowered homocysteine in MTHFR TT subjects—clear effect on flavin-dependent metabolism.
- Riboflavin status in acute ischaemic stroke
PubMed ID: 17299470
Rapid correction of deficiency in stroke patients shows riboflavin supplementation restores cofactors needed for metabolic (energy) pathways.
- Correcting a marginal riboflavin deficiency improves hematologic status in young women in the United Kingdom (RIBOFEM)
PubMed ID: 21525198
Riboflavin supplementation improved EGRAC (riboflavin status) dose-dependently—directly reflects improved availability of riboflavin as a metabolic cofactor for energy conversion.
- Plasma riboflavin is a useful marker for studying riboflavin requirement in Chinese male adults
PubMed ID: 27188899
Dose‑response increases in plasma and urinary riboflavin and estimated EAR are directly relevant to riboflavin’s role as an energy metabolism cofactor (FAD/FMN).
- Effect of micronutrient pack on micronutrient status and antioxidant capacities among institutional older adults in Shanghai, China
PubMed ID: 31464392
Micronutrient pack increased B2 levels in older adults, supporting biochemical pathways for energy production.
- Multiple micronutrient supplementation improves anemia, micronutrient nutrient status, and growth of Vietnamese infants: double-blind, randomized, placebo-controlled trial
PubMed ID: 15735111
Daily multiple micronutrients (including riboflavin) markedly increased infants' hemoglobin and ferritin versus controls—likely to reduce tiredness associated with anemia, although contribution of riboflavin alone is unclear.
- Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, growth, and morbidity of Peruvian infants
PubMed ID: 15735109
Daily multi‑micronutrient supplementation improved hemoglobin and maintained ferritin in Peruvian infants—relevant to reducing fatigue from anemia; riboflavin was part of the mix.
- Micronutrient supplementation improves physical performance measures in Asian Indian school-age children
PubMed ID: 21918063
Daily multi-micronutrient beverage (included riboflavin) improved children's aerobic capacity/endurance—consistent with improved energy performance though effect cannot be isolated to riboflavin alone.
- Fortified breakfast cereal consumed daily for 12 wk leads to a significant improvement in micronutrient intake and micronutrient status in adolescent girls: a randomised controlled trial
PubMed ID: 27418034
Fortified cereal markedly improved biochemical riboflavin status (EGRAC), directly supporting riboflavin's role as an essential cofactor in cellular energy metabolism.
- [The result of prospective randomized study CITADEL - the efficacy and safety of drug cytoflavin in postcovid rehabilitation]
PubMed ID: 34874654
Cytoflavin treatment produced measurable reductions in fatigue (post‑COVID) — contains riboflavin among active components.
- B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine
PubMed ID: 37880581
Lower FMN (a riboflavin vitamer) associated with fatigue in IBD patients — mechanistic/biomarker link between riboflavin status and energy/fatigue.
Pregnancy support (13)
- Assessment of dietary intake among pregnant women in a rural area of western China
PubMed ID: 19589154
Large dietary survey showed widespread inadequate riboflavin intake among pregnant women—supports relevance of B2 for pregnancy nutritional needs and risk of deficiency.
- Macro- and Micronutrients in Milk from Healthy Cambodian Mothers: Status and Interrelations
PubMed ID: 32211800
Most Cambodian breastmilk samples contained low riboflavin — implies maternal/infant nutritional shortfall relevant to perinatal wellness.
- Antiretroviral therapy provided to HIV-infected Malawian women in a randomized trial diminishes the positive effects of lipid-based nutrient supplements on breast-milk B vitamins
PubMed ID: 26537941
Large randomized maternal supplementation trial raised multiple B‑vitamin concentrations in breast milk (including riboflavin), directly relevant to maternal/infant nutrition.
- Supplementation of iron alone and combined with vitamins improves haematological status, erythrocyte membrane fluidity and oxidative stress in anaemic pregnant women
PubMed ID: 20615267
Iron plus added vitamins including riboflavin raised hemoglobin and improved RBC/oxidative markers in anemic pregnant women—demonstrates clinical benefit of the fortified regimen in pregnancy.
- Retinol and riboflavin supplementation decreases the prevalence of anemia in Chinese pregnant women taking iron and folic Acid supplements
PubMed ID: 18806105
In anemic pregnant women, adding retinol+riboflavin to iron+folic acid reduced anemia prevalence—beneficial for pregnancy wellness though multi‑nutrient.
- A micronutrient-fortified beverage prevents iron deficiency, reduces anemia and improves the hemoglobin concentration of pregnant Tanzanian women
PubMed ID: 12730420
Pregnant women receiving fortified beverage saw improved hemoglobin and ferritin and reduced anemia risk—clinically relevant pregnancy wellness outcomes from a multi‑micronutrient approach.
- Antenatal supplementation with micronutrients and biochemical indicators of status and subclinical infection in rural Nepal
PubMed ID: 16600929
Large antenatal RCT showed multiple‑micronutrient supplementation (including riboflavin) ameliorated pregnancy‑related declines in riboflavin status—directly relevant to maternal nutrient status in pregnancy.
- Multicentric study of efficacy of periconceptional folic acid containing vitamin supplementation in prevention of open neural tube defects from India
PubMed ID: 11247198
Periconceptional multivitamin (including riboflavin) associated with fewer recurrent NTDs (substantial though not statistically significant); plausible contribution from B vitamins including B2.
- Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
PubMed ID: 38051700
Large randomized trial of preconception/pregnancy multinutrient supplementation including riboflavin markedly raised plasma riboflavin and reduced marginal deficiency—directly relevant to pregnancy nutritional status.
- Improving women's diet quality preconceptionally and during gestation: effects on birth weight and prevalence of low birth weight--a randomized controlled efficacy trial in India (Mumbai Maternal Nutrition Project)
PubMed ID: 25332324
Preconception/antenatal food supplementation (contained small amounts of riboflavin) increased newborn weight modestly and reduced low birth weight in some comparisons—relevant to pregnancy outcomes.
- Vitamin supplementation of HIV-infected women improves postnatal child growth
PubMed ID: 15817867
Maternal multivitamin supplementation (including riboflavin) during pregnancy/breastfeeding led to heavier children at age 2—supports maternal supplementation benefits for offspring health.
- Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension
PubMed ID: 15987864
Large randomized trial: multivitamins (including riboflavin) substantially lowered pregnancy hypertension risk in HIV‑positive women—strong evidence for improved pregnancy outcomes from the combined supplement.
- Effects of a combined micronutrient supplementation on maternal biological status and newborn anthropometrics measurements: a randomized double-blind, placebo-controlled trial in apparently healthy pregnant women
PubMed ID: 14679367
Daily micronutrient supplement raised maternal riboflavin and other vitamin levels and increased newborn birth weight (~+10%); B2 was part of effective MN mix.
Metabolism (15)
- Effects of multivitamin/mineral supplementation on plasma levels of nutrients. Report No. 4 of the Italian-American clinical trial of nutritional supplements and age-related cataract
PubMed ID: 19636163
Long‑term multivitamin raised blood riboflavin (B2) levels in older adults—B2 is a metabolic cofactor, so improved status supports metabolic function (indirect evidence).
- [Assessment of efficiency of dietotherapy with addition of a vitamin-mineral complex in patients with diabetes mellitus type 2]
PubMed ID: 25300112
A multivitamin (including B2) improved glycemia in type 2 diabetes; B2 not isolated but study is directly metabolic.
- Metabolomic profiling of urine: response to a randomised, controlled feeding study of select fruits and vegetables, and application to an observational study
PubMed ID: 23657156
Metabolomic urine profiling found higher riboflavin and acylcarnitine excretion (energy‑metabolism markers), implying metabolic effects.
- Riboflavin Supplementation Promotes Butyrate Production in the Absence of Gross Compositional Changes in the Gut Microbiota
PubMed ID: 35943883
RIBOGUT RCT: oral riboflavin increased fecal butyrate and microbial network interactions — clear metabolic effect on gut microbial metabolism.
- A Community-Based Early Childhood Development Center Platform Promoting Diversified Diets and Food Production Increases the Mean Probability of Adequacy of Intake of Preschoolers in Malawi: A Cluster Randomized Trial
PubMed ID: 31616933
Childcare agriculture/nutrition program increased riboflavin adequacy in preschoolers (metabolic/nutritional relevance).
- Fortified breakfast cereal consumed daily for 12 wk leads to a significant improvement in micronutrient intake and micronutrient status in adolescent girls: a randomised controlled trial
PubMed ID: 27418034
Fortified cereal with riboflavin clearly normalized biochemical riboflavin status (EGRAC), supporting metabolic co‑factor roles.
- Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation
PubMed ID: 12194936
Direct riboflavin supplementation (1.6 mg/day) produced large increases in plasma/erythrocyte flavin vitamers, demonstrating metabolic status improvement.
- A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status
PubMed ID: 36128889
Multi‑B‑vitamin trial (including riboflavin) improved riboflavin biomarker (EGRac) and lowered homocysteine — supports metabolic one‑carbon roles.
- [Bioavailability of natural versus synthetic B vitamins and their effects on metabolic processes]
PubMed ID: 32189314
B‑vitamin complexes raised serum B2 and affected homocysteine and metabolic markers in healthy adults.
- Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status
PubMed ID: 12209373
Riboflavin pills in deficient elderly improved EGRAC (riboflavin status) though did not lower homocysteine—strong biomarker evidence for metabolic repletion.
- Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study)
PubMed ID: 17932361
Riboflavin supplementation improved riboflavin biomarkers and modulated folate responses (including genotype interactions) — supports role in one‑carbon metabolism.
- Urinary Metabolomic Profiling Analysis and Evaluation of the Effect of Ecklonia cava Extract Intake
PubMed ID: 32422870
Seapolynol increased urinary riboflavin that correlated inversely with body‑fat reductions.
- Improvements in Glycemic, Micronutrient, and Mineral Indices in Arab Adults with Pre-Diabetes Post-Lifestyle Modification Program
PubMed ID: 31731609
Nutrition/lifestyle program raised dietary riboflavin and improved glycemic indices (confounded but relevant).
- Impact of the MTHFR C677T polymorphism on one-carbon metabolites: Evidence from a randomised trial of riboflavin supplementation
PubMed ID: 32330571
Riboflavin supplementation in MTHFR 677TT genotype corrected one‑carbon metabolites (SAM, cystathionine), a direct metabolic effect.
- Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects
PubMed ID: 16391577
Randomized trial showed riboflavin modified folic acid effects on plasma total homocysteine and altered ALT — direct metabolic interactions.
Growth support (15)
- Antiretroviral therapy provided to HIV-infected Malawian women in a randomized trial diminishes the positive effects of lipid-based nutrient supplements on breast-milk B vitamins
PubMed ID: 26537941
Maternal supplementation raised milk B‑vitamins including riboflavin, which is directly relevant to infant nutrient supply and development.
- Vitamin supplementation of HIV-infected women improves postnatal child growth
PubMed ID: 15817867
Maternal multivitamin (including riboflavin) during pregnancy and lactation resulted in heavier children at 2 years—supports growth outcomes associated with maternal micronutrient status.
- Improving women's diet quality preconceptionally and during gestation: effects on birth weight and prevalence of low birth weight--a randomized controlled efficacy trial in India (Mumbai Maternal Nutrition Project)
PubMed ID: 25332324
Large randomized preconception/antenatal food supplementation (contained small riboflavin amounts) produced modest increases in newborn weight and reduced LBW in some analyses.
- [Effects of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on iron metabolic homeostasis]
PubMed ID: 22336361
Child fortification trial (multi‑micronutrient including riboflavin) increased total body iron and altered iron markers—relevant to growth but riboflavin not isolated.
- The Nutritional Impact of Milk Beverages in Reducing Nutrient Inadequacy among Children Aged One to Five Years in the Philippines: A Dietary Modelling Study
PubMed ID: 33138121
Dietary modeling showed one serving of fortified milk would nearly eliminate riboflavin shortfalls in Filipino children—direct relevance to child growth/nutrition.
- Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder-A Randomized, Controlled 12-Month Trial
PubMed ID: 29562612
Comprehensive nutrition/diet program produced a very large increase in riboflavin biomarker and was associated with large developmental gains in ASD participants — multi‑ingredient but strong association.
- Impacts of an egg intervention on nutrient adequacy among young Malawian children
PubMed ID: 33974324
Large infant trial: daily eggs increased riboflavin intake and reduced riboflavin inadequacy — direct relevance to childhood growth/development nutrition.
- Effect of B vitamins-fortified foods on primary school children in Beijing
PubMed ID: 16883966
School‑based riboflavin fortification improved biomarkers and a cognitive/school performance index, supporting child developmental outcomes linked to nutrition.
- Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial
PubMed ID: 26678525
Direct measurement: formula‑fed infants had substantially higher riboflavin and better gross motor development scores at 6 months — strong developmental linkage.
- Multiple micronutrient supplementation improves anemia, micronutrient nutrient status, and growth of Vietnamese infants: double-blind, randomized, placebo-controlled trial
PubMed ID: 15735111
Daily multi‑micronutrients slowed decline in length‑for‑age Z‑score in infants (less linear growth faltering) while improving micronutrient status including riboflavin.
- Fortified breakfast cereal consumed daily for 12 wk leads to a significant improvement in micronutrient intake and micronutrient status in adolescent girls: a randomised controlled trial
PubMed ID: 27418034
Improved riboflavin status in adolescent girls via fortified cereal supports nutrient sufficiency important for growth/development.
- Effect of zinc plus multivitamin supplementation on growth in school children
PubMed ID: 27083763
Zinc + multivitamin (includes B2) produced clinically meaningful additional height gain in schoolchildren over 6 months—riboflavin may contribute but product is multi‑nutrient.
- [Clinical-encephalographic evaluation of preterm children treated with cytoflavin during the first year of life]
PubMed ID: 21666588
Preterm infants given cytoflavin (includes riboflavin) showed faster neurological/developmental normalization—supports developmental/growth endpoints albeit multi-agent.
- A Community-Based Early Childhood Development Center Platform Promoting Diversified Diets and Food Production Increases the Mean Probability of Adequacy of Intake of Preschoolers in Malawi: A Cluster Randomized Trial
PubMed ID: 31616933
Large cluster RCT in preschoolers increased riboflavin probability of adequacy—directly relevant to development.
- Macro- and Micronutrients in Milk from Healthy Cambodian Mothers: Status and Interrelations
PubMed ID: 32211800
Frequent low breastmilk B2 in Cambodian mothers implies risk to infant nutrient supply and development.
Brain health (12)
- [Modern methods of energy homeostasis correction in elderly patients]
PubMed ID: 25946854
Cytoflavin reduced ischemic lesion size and improved clinical outcomes after acute stroke, indicating improved brain recovery (not B2‑isolated).
- [The effectiveness of Cytoflavin in the medical rehabilitation of elderly and senile patients]
PubMed ID: 39731767
Cytoflavin in elderly COVID‑19 rehab improved MMSE and other cognitive measures — supports cognitive recovery though multi‑component.
- [Efficacy of antioxidant energocorreсtion in brain infarction (results of a multicenter randomized trial)]
PubMed ID: 25591516
Multicenter trial showed Cytoflavin reduced infarct volume and improved neurologic/functional recovery after ischemic stroke.
- [EFFECTIVENESS OF CYTOFLAVIN FOR THE CORRECTION OF COGNITIVE IMPAIRMENTS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS]
PubMed ID: 27017701
Cytoflavin (includes riboflavin) produced measurable improvements in MoCA and increased BDNF in people with type 2 diabetes—strong relevance to cognitive support though multi‑component.
- [An effect of cytoprotective therapy on stress resistance and compensatory abilities of patients with chronic cerebral ischemia]
PubMed ID: 26978497
Cytoflavin improved 1‑year outcomes in chronic cerebral ischemia patients, relevant to long‑term brain health though multi‑ingredient attribution limits specificity.
- Early predictive blood markers of hemorrhagic stroke - influence of cytoflavin therapy
PubMed ID: 32910863
Cytoflavin use in hemorrhagic stroke associated with lower in‑hospital deaths and stabilization of lab markers—suggestive of neurological benefit (multi‑component).
- [Improving the effectiveness of treatment of patients with post-stroke aphasia]
PubMed ID: 39575955
Cytoflavin adjunct in post‑stroke rehab improved aphasia and disability — clinically meaningful cognitive/neurological improvements associated with a formulation containing riboflavin.
- [Clinical and morphologic efficacy of a complex antioxidant and energy correction therapy of different duration in brain infarction: results of a multicenter randomized trial]
PubMed ID: 26356615
Cytoflavin reduced ischemic lesion volumes and improved clinical recovery after stroke—relevant to brain recovery but not riboflavin‑specific.
- Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
PubMed ID: 25916335
Supplement containing high‑dose riboflavin showed reduced migraine pain intensity and lowered HIT‑6 burden — neurologic/cognitive symptom benefit though multi‑component.
- Effect of B vitamins-fortified foods on primary school children in Beijing
PubMed ID: 16883966
Riboflavin‑fortified foods raised biomarkers and improved a school performance/cognitive index in a randomized trial — direct evidence for cognitive/brain benefit in children.
- Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial
PubMed ID: 9484373
RCT showing reduced migraine frequency with high-dose riboflavin—clear neurological benefit though migraine is a specific neurological disorder rather than broad cognition.
- [Effect of early correction of energy and free-radical homeostasis on the clinical-morphological presentation of cerebral infarction]
PubMed ID: 20823824
Cytoflavin early after ischemic stroke improved consciousness and neurologic scores; riboflavin is a component but the product is multi‑agent.
Nutrient uptake (10)
- Effect of a fortified maize-meal porridge on anemia, micronutrient status, and motor development of infants
PubMed ID: 16280435
Fortified maize increased serum ferritin and reduced anemia in infants, indicating improved iron status/utilization; riboflavin was one component.
- Micronutrient-Fortified Milk and Academic Performance among Chinese Middle School Students: A Cluster-Randomized Controlled Trial
PubMed ID: 28257107
Fortified milk improved vitamin B2 (riboflavin) biomarkers and reduced odds of iron deficiency in children—direct nutritional evidence that coincided with better iron status.
- Multiple micronutrient supplementation improves anemia, micronutrient nutrient status, and growth of Vietnamese infants: double-blind, randomized, placebo-controlled trial
PubMed ID: 15735111
Daily multi‑micronutrients improved ferritin and hemoglobin in infants—evidence that combined supplementation improved iron handling, with riboflavin included.
- Correcting a marginal riboflavin deficiency improves hematologic status in young women in the United Kingdom (RIBOFEM)
PubMed ID: 21525198
Riboflavin supplementation improved riboflavin status and increased hemoglobin despite unchanged measured iron absorption—suggests improved utilization/erythropoiesis in deficient women.
- Supplementation of iron alone and combined with vitamins improves haematological status, erythrocyte membrane fluidity and oxidative stress in anaemic pregnant women
PubMed ID: 20615267
Iron + added vitamins including riboflavin produced larger hemoglobin and ferritin increases and improved erythrocyte measures in anemic pregnant women—evidence that the combined regimen improved iron‑related outcomes.
- Retinol and riboflavin supplementation decreases the prevalence of anemia in Chinese pregnant women taking iron and folic Acid supplements
PubMed ID: 18806105
Adding retinol+riboflavin to iron+folic acid further reduced anemia in pregnant women, indicating improved hematologic response when riboflavin present.
- A micronutrient-fortified beverage prevents iron deficiency, reduces anemia and improves the hemoglobin concentration of pregnant Tanzanian women
PubMed ID: 12730420
Multi‑micronutrient beverage raised ferritin and reduced iron‑deficiency anemia in pregnant women—relevant to dietary iron utilization though effect is from the combined product.
- Effect of low-dosage vitamin A and riboflavin on iron-folate supplementation in anaemic pregnant women
PubMed ID: 12495257
Adding riboflavin to iron–folate therapy in anaemic pregnant women tended to improve haemoglobin response, suggesting enhanced iron utilization.
- The Nutritional Impact of Milk Beverages in Reducing Nutrient Inadequacy among Children Aged One to Five Years in the Philippines: A Dietary Modelling Study
PubMed ID: 33138121
Fortified milk modeling reduced iron shortfalls alongside riboflavin, suggesting programmatic co‑benefit for iron nutrition.
- [Effects of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on iron metabolic homeostasis]
PubMed ID: 22336361
Multi‑micronutrient food fortification that included riboflavin produced significant improvements in ferritin, sTfR and total body iron in children; attribution to riboflavin is indirect.
Healthy aging (5)
- Riboflavin and vitamin B-6 intakes and status and biochemical response to riboflavin supplementation in free-living elderly people
PubMed ID: 9701198
Low-dose riboflavin corrected deficiency and improved B6 markers in elderly—supports physiological status important for healthy aging.
- The effects of a multivitamin/mineral supplement on micronutrient status, antioxidant capacity and cytokine production in healthy older adults consuming a fortified diet
PubMed ID: 11022875
Multivitamin improved riboflavin status in older adults—biochemical improvement relevant to healthy aging.
- Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish osteoporosis prevention study
PubMed ID: 15777680
Large observational link: low riboflavin intake associated with lower hip BMD in MTHFR TT women — plausible aging/bone relevance in genetic subgroup.
- The Association of Dietary Lutein plus Zeaxanthin and B Vitamins with Cataracts in the Age-Related Eye Disease Study: AREDS Report No. 37
PubMed ID: 25972257
Large observational cohort found higher dietary riboflavin intake associated with lower odds of some cataract types (age‑related eye disease).
- Effect of micronutrient pack on micronutrient status and antioxidant capacities among institutional older adults in Shanghai, China
PubMed ID: 31464392
In institutionalized older adults a micronutrient pack including B2 increased B2 and improved antioxidant markers relevant to aging.
Antioxidant (8)
- Effect of micronutrient pack on micronutrient status and antioxidant capacities among institutional older adults in Shanghai, China
PubMed ID: 31464392
Randomized micronutrient supplement (includes B2) raised serum B2 and decreased MDA, showing improved antioxidant activity.
- [Effect of early correction of energy and free-radical homeostasis on the clinical-morphological presentation of cerebral infarction]
PubMed ID: 20823824
Cytoflavin (contains riboflavin) trial showed reduced oxidative markers after ischemic stroke; multi‑component product limits attribution to B2 alone.
- [Efficacy of cytoflavin in the treatment of burns patients with toxic and post-hypoxic encephalopathy]
PubMed ID: 21183910
Cytoflavin (contains riboflavin) reduced lipid peroxidation and organ-dysfunction index after severe burns—evidence of antioxidant/oxidative‑stress reduction with the combination.
- A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels
PubMed ID: 31915511
Natural B‑complex increased total antioxidant capacity and lowered homocysteine in a randomized pilot — direct antioxidant biomarker change linked to B2-containing supplement.
- Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: a randomized controlled trial
PubMed ID: 16517955
Trial including B‑group vitamins (5 mg B2) showed increased total antioxidant capacity and reduced MDA (oxidative damage) — strong biochemical support though vitamins were combined.
- Treatment of Alzheimer's disease with a cholinesterase inhibitor combined with antioxidants
PubMed ID: 20224285
Antioxidant + B‑vitamin mix (including riboflavin) lowered oxidative markers and raised erythrocyte glutathione in Alzheimer patients; implicates antioxidant benefit of the combination.
- Antioxidant micronutrients and biomarkers of oxidative stress and inflammation in colorectal adenoma patients: results from a randomized, controlled clinical trial
PubMed ID: 20200432
Multi-antioxidant trial (includes riboflavin) produced significant reductions in oxidative/inflammatory markers; attribution to B2 alone uncertain but study supports antioxidant effects of the formula.
- Lack of association between indices of vitamin B1, B2, and B6 status and exercise-induced blood lactate in young adults
PubMed ID: 8508194
Improved glutathione reductase activity (riboflavin-dependent enzyme) indicating enhanced antioxidant capacity.
Focus & concentration (6)
- [Pathogenetic and therapeutic approaches to the correction of neurocognitive disorders in patients with chronic brucellosis]
PubMed ID: 41524166
Cytoflavin infusions improved MoCA and quality of life in chronic brucellosis—stronger cognitive signal though again multi‑component.
- [EFFECTIVENESS OF CYTOFLAVIN FOR THE CORRECTION OF COGNITIVE IMPAIRMENTS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS]
PubMed ID: 27017701
Cytoflavin (contains riboflavin) improved MoCA and cognitive domains in T2D — mental focus gains observed with the multi‑ingredient product.
- Effect of B vitamins-fortified foods on primary school children in Beijing
PubMed ID: 16883966
Primary-school children receiving B‑vitamin (including riboflavin) fortified foods had improved riboflavin biomarkers and a measurable improvement in a school performance (cognitive) index.
- [The result of prospective randomized study CITADEL - the efficacy and safety of drug cytoflavin in postcovid rehabilitation]
PubMed ID: 34874654
Cytoflavin group had improved cognitive scores post‑COVID (MMSE) — multi‑ingredient but relevant to focus.
- [The effectiveness of Cytoflavin in the medical rehabilitation of elderly and senile patients]
PubMed ID: 39731767
Cytoflavin improved MMSE and reduced fatigue in COVID‑19 rehab—supports improved cognition/mental focus (multi‑ingredient).
- [Improving the effectiveness of treatment of patients with post-stroke aphasia]
PubMed ID: 39575955
Cytoflavin adjunct to post‑stroke therapy associated with better aphasia recovery and verbal communication—indirect evidence for cognitive/mental focus benefits (combination product).
Heart health (5)
- Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism
PubMed ID: 16380544
Riboflavin supplementation produced large homocysteine reductions in MTHFR 677TT subjects—lowering homocysteine is plausibly cardioprotective, especially in this genotype group.
- Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up
PubMed ID: 22277556
Riboflavin supplementation produced substantial BP reductions in genetically at-risk (MTHFR 677TT) patients — clinically relevant cardiovascular benefit.
- Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial
PubMed ID: 23608654
Randomized trial showed riboflavin (1.6 mg) lowered systolic BP in MTHFR 677TT hypertensive patients — strong genotype-specific heart-health evidence.
- Impact of the MTHFR C677T polymorphism on one-carbon metabolites: Evidence from a randomised trial of riboflavin supplementation
PubMed ID: 32330571
Improved one‑carbon metabolism (reduced homocysteine risk) in MTHFR TT carriers could lower cardiovascular risk mechanisms — plausible link.
- A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
PubMed ID: 31408467
Supplement including riboflavin lowered homocysteine, a cardiovascular risk marker; multi‑nutrient but clinically relevant to heart health.
Immune support (5)
- Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal disease: a randomized, double-blind, placebo-controlled, multicenter trial
PubMed ID: 25746727
Dialysis patients on a multinutrient supplement that included riboflavin showed decreased HHV7 reactivation, an objective immune marker (riboflavin not isolated).
- Effect of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on infectious morbidity of preschool children
PubMed ID: 20605698
Multi-micronutrient seasoning that included riboflavin reduced respiratory and diarrheal illness in preschool children—strong clinical immune-related outcome though riboflavin was one of many nutrients.
- Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome- a pilot study
PubMed ID: 33615992
Colonic delivery of B2 changed gut microbial diversity and SCFAs, which can modulate immune function.
- Effect of Plasmodium inactivation in whole blood on the incidence of blood transfusion-transmitted malaria in endemic regions: the African Investigation of the Mirasol System (AIMS) randomised controlled trial
PubMed ID: 27116282
Riboflavin pathogen‑reduction of donor blood significantly reduced transfusion‑transmitted malaria incidence—direct immune/protective benefit for recipients.
- [Clinical effectiveness of cytoflavin inclusion in intensive care of patients with combined traumatic brain injury]
PubMed ID: 25076759
Cytoflavin reduced purulent‑septic complications in ICU TBI patients — suggests an effect on infection outcomes though multi‑ingredient unclear attribution.
Stress resilience (2)
- Impact of Vitamin B1 and Vitamin B2 Supplementation on Anxiety, Stress, and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 40507089
Randomized B1+B2 supplementation for 4 weeks improved perceived stress and sleep metrics in young adults.
- [An effect of cytoprotective therapy on stress resistance and compensatory abilities of patients with chronic cerebral ischemia]
PubMed ID: 26978497
Large study reported cytoflavin improved clinical outcomes and optimized stress‑system activity; relevance to stress resilience moderate but multi‑component product.
Skin health (2)
- Multiple micronutrient fortification of salt and its effect on cognition in Chennai school children
PubMed ID: 17704033
School use of multi‑micronutrient‑fortified salt (including riboflavin) eliminated angular stomatitis and improved RBC/hemoglobin — clear mucocutaneous benefit in a multi‑nutrient context.
- Topical riboflavin versus 5-aminolevulinic acid photodynamic therapy for the treatment of mild to moderate acne: A split-face randomized study
PubMed ID: 39709022
Topical riboflavin‑PDT performed as well as ALA‑PDT for acne with significantly less pain and fewer post‑treatment skin effects — direct, high-relevance evidence for a riboflavin skin application.
Mood balance (1)
- Impact of Vitamin B1 and Vitamin B2 Supplementation on Anxiety, Stress, and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 40507089
B1+B2 supplementation reduced perceived stress (PSS) compared with placebo—direct patient‑reported mood/stress benefit though product combined vitamins.
Liver support (1)
- Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects
PubMed ID: 16391577
Small RCT showed riboflavin (with/without folic acid) associated with decreased ALT versus folic acid alone, indicating a modest effect on a liver enzyme marker.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Riboflavin
Search all16805 products whose verified label declares Riboflavin — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.