Digestive Enzymes
7 benefits mapped to clinical evidence across supplements.
Dose per serving from products
144 products in our catalogue print how much Digestive Enzymes a serving holds.
Most common: 50 mg to 100 mg, 44% of 144 products.
| Dose per serving | Products |
|---|---|
| 500 mcg to 1 mg | 11 |
| 1 mg to 2.5 mg | 0 |
| 2.5 mg to 5 mg | 2 |
| 5 mg to 10 mg | 13 |
| 10 mg to 25 mg | 8 |
| 25 mg to 50 mg | 19 |
| 50 mg to 100 mg | 63 |
| 100 mg to 250 mg | 25 |
| over 250 mg | 3 |
Dose per serving from research
17 study groups in 13 studies say how much Digestive Enzymes participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mg to 1 g, 29% of 17 study groups.
| Daily dose | Study groups |
|---|---|
| 25 mg to 50 mg | 2 |
| 50 mg to 100 mg | 1 |
| 100 mg to 250 mg | 1 |
| 250 mg to 500 mg | 3 |
| 500 mg to 1 g | 5 |
| 1 g to 2.5 g | 1 |
| 2.5 g to 5 g | 1 |
| 5 g to 10 g | 2 |
| over 10 g | 1 |
Benefit Evidence
Research sources
Digestive support (150)
- Phosphorus digestibility response of growing pigs to phytase supplementation of triticale distillers' dried grains with solubles
PubMed ID: 26020749
Growing‑pig trial: phytase increased apparent P digestibility—supports enzyme-driven digestive improvements in animal model.
- Effect of probiotics on postoperative quality of gastric bypass surgeries: a prospective randomized trial
PubMed ID: 26499352
Human RCT after gastric bypass: digestive‑enzyme arm reported modest improvements in GI symptoms and GI‑specific quality of life within 2 weeks, directly supporting improved gut comfort.
- Assessment of enzyme supplementation on growth performance and apparent nutrient digestibility in diets containing undecorticated sunflower seed meal in layer chicks
PubMed ID: 26047672
Exogenous enzymes in layer chicks increased nutrient digestibility and weight gain — consistent with improved digestion.
- Effect of pronase as mucolytic agent on imaging quality of magnifying endoscopy
PubMed ID: 25741158
Pronase (oral protease) improved gastric mucus/protein clearing and visibility during endoscopy (human RCT), demonstrating effective proteolytic activity in the stomach that eases breakdown of proteinaceous material.
- Energy utilization and growth performance of chickens fed novel wheat inbred lines selected for different pentosan levels with and without xylanase supplementation
PubMed ID: 25595480
Broiler xylanase improved carbohydrate (NSP) handling and increased dry‑matter/fat digestibility, showing enzymatic facilitation of feed component breakdown (animal model).
- Prophylactic somatostatin can reduce incidence of post-ERCP pancreatitis: multicenter randomized controlled trial
PubMed ID: 25590178
Somatostatin reduced post‑ERCP pancreatitis and hyperamylasemia — clinically reduced a cause of severe gut pain/discomfort (procedural context).
- Continual feeding of two types of microalgal biomass affected protein digestion and metabolism in laying hens
PubMed ID: 25568377
Exogenous protease improved ileal AA digestibility in hens — clear evidence enzymes facilitate protein breakdown (animal model).
- A double-blind, randomized, placebo-controlled trial studying the effects of Saccharomyces boulardii on the gastrointestinal tolerability, safety, and pharmacokinetics of miglustat
PubMed ID: 26084276
S. boulardii co‑administration decreased diarrhea days and GI AE incidence in miglustat users — direct evidence for improved gut comfort in humans with enzyme‑related malabsorption.
- Apparent and standardized total tract digestibility by growing pigs of phosphorus in canola meal from North America and 00-rapeseed meal and 00-rapeseed expellers from Europe without and with microbial phytase
PubMed ID: 26440018
Microbial phytase added to diets markedly improved phosphorus digestibility — strong direct evidence that exogenous enzyme supplementation improves digestion (animal model).
- Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease
PubMed ID: 24583059
ALV003 prevented gluten‑induced mucosal injury and intraepithelial lymphocyte increases; clinically this maps to better gut comfort during gluten exposure in celiac patients.
- The effect of oral pancreatic enzyme supplementation on the course and outcome of acute pancreatitis: a randomized, double-blind parallel-group study
PubMed ID: 24618443
Pancreatic enzyme supplementation directly supplies missing digestive enzymes (lipase/protease/amide), facilitating food breakdown in enzyme‑deficient/recovering patients.
- [Efficacy of compound digestive enzyme tablet for dyspeptic symptoms: a randomized double-blind parallel controlled multicenter clinical trial in China]
PubMed ID: 25622633
High overall efficacy (~80%) of compound digestive‑enzyme formulations in dyspepsia patients indicates substantial improvement in mealtime comfort.
- Prevalence of lactose intolerance in Chile: a double-blind placebo study
PubMed ID: 25096822
Study documents high prevalence of lactase nonpersistence and concordance with lactose malabsorption/symptoms—supports rationale for lactase enzyme use to ease dairy digestion.
- Effects of dietary supplementation of multi-enzyme on growth performance, nutrient digestibility, small intestinal digestive enzyme activities, and large intestinal selected microbiota in weanling pigs
PubMed ID: 24663197
Multi-enzyme feed in piglets increased apparent digestibility (DM/CP/GE) and intestinal enzyme activities—direct evidence for improved digestion.
- Xylanase supplementation of a wheat-based diet improved nutrient digestion and mRNA expression of intestinal nutrient transporters in broiler chickens infected with Clostridium perfringens
PubMed ID: 24570428
Exogenous xylanase in poultry improved digestion of fiber-containing feed, facilitating food breakdown (animal evidence).
- Fecal microbiota transplantation alleviates mild-moderate COVID-19 associated diarrhoea and depression symptoms: A prospective study of a randomized, double-blind clinical trial
PubMed ID: 39056206
FMT rapidly resolved diarrhoea and improved related symptoms — strong direct effect on gut comfort.
- Lubiprostone in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled, phase 2a trial
PubMed ID: 32805205
Lubiprostone is used to treat constipation and demonstrably increases regularity—highly relevant.
- A Whole-Food-Based Health Product (A-F Betafood(®)) Improves Gallbladder Function in Humans at Risk of Gallbladder Insufficiency: A Randomized, Placebo-Controlled Clinical Trial
PubMed ID: 32093137
Improved gallbladder ejection fraction strongly suggests better emulsification and fat digestion.
- Safety and Efficacy of N-SORB(®), a Proprietary KD120 MEC Metabolically Activated Enzyme Formulation: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 30971174
Direct RCT of a multienzyme digestive supplement (N‑SORB) in healthy volunteers showed modest QoL/subjective digestion improvements.
- Gut Permeability Might be Improved by Dietary Fiber in Individuals with Nonalcoholic Fatty Liver Disease (NAFLD) Undergoing Weight Reduction
PubMed ID: 30453660
Fiber intervention reduced zonulin and improved markers, suggesting improved gut barrier and comfort.
- [Effect of rhubarb as the main composition of sequential treatment in patients with acute paraquat poisoning: a prospective clinical research]
PubMed ID: 25891453
Rhubarb‑based TCM significantly shortened time to first defecation — direct evidence for accelerated/regular bowel activity in that context.
- Urinary (1)H-NMR-based metabolic profiling of children with NAFLD undergoing VSL#3 treatment
PubMed ID: 25809828
Probiotic intervention changed urinary metabolites and correlated with liver/BMI markers; probiotics commonly improve subjective gut comfort.
- Fat-Modified Enteral Formula Improves Feeding Tolerance in Critically Ill Patients: A Multicenter, Single-Blind, Randomized Controlled Trial
PubMed ID: 26350918
Enteral MCT/carnitine/taurine formula reduced feeding intolerance and abdominal distension—direct evidence for improved gut comfort.
- Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study
PubMed ID: 24401715
Synbiotic RCT improved liver/inflammation and is likely to improve gut comfort via microbiome modulation.
- [Effect of post-liver transplantation administration of ursodeoxycholic acid on serum liver tests and biliary complications: a randomized clinical trial]
PubMed ID: 25203806
UDCA improved biliary sludge/casts and lowered enzymes—directly relevant to bile-mediated fat digestion.
- The efficacy of rebamipide add-on therapy in arthritic patients with COX-2 selective inhibitor-related gastrointestinal events: a prospective, randomized, open-label blinded-endpoint pilot study by the GLORIA study group
PubMed ID: 23306427
Randomized addition of rebamipide to celecoxib prevented endoscopic ulcers and intolerable GI symptoms—direct evidence of improved GI comfort (though not an enzyme).
- Enteral nutrition is superior to total parenteral nutrition for pancreatic cancer patients who underwent pancreaticoduodenectomy
PubMed ID: 21669582
Enteral feeding post‑PD markedly reduced delayed gastric emptying (0% vs 20%) — strong evidence for more regular digestion in this surgical setting.
- Bifidobacterium longum with fructo-oligosaccharides in patients with non alcoholic steatohepatitis
PubMed ID: 21901256
Probiotic+FOS improved liver/inflammation and endotoxin levels in NASH — suggests improved gut environment and comfort.
- Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study
PubMed ID: 19038698
Probiotic supplementation restored beneficial bacteria and rapidly improved some liver markers in alcoholics, implying better gut environment/comfort.
- Augmented eradication rates of Helicobacter pylori by new combination therapy with lansoprazole, amoxicillin, and rebamipide
PubMed ID: 9512112
Adding rebamipide to eradication therapy reduced mucosal oxidative markers and improved eradication rates, likely improving GI comfort.
- Efficacy of ursodeoxycholic acid therapy in chronic viral hepatitis C with high serum gamma-glutamyltranspeptidase levels
PubMed ID: 8808432
UDCA is a bile acid used to improve bile composition and fat handling; the study showed biochemical improvements consistent with better fat digestion (strong indirect support).
- Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome: A prospective, interventional, randomized, double-blind, placebo-controlled clinical study [CONSORT Compliant]
PubMed ID: 33545934
Randomized probiotic study showed substantial improvement in abdominal pain and stool consistency—clear gut comfort benefit (though probiotic, not enzyme).
- Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients With Celiac Disease Exposed to a Gluten Challenge
PubMed ID: 35931103
Latiglutenase is an oral proteolytic enzyme shown to enzymatically degrade gluten and prevent mucosal/symptomatic damage—direct evidence of easier breakdown of targeted substrate.
- Efficacy of digestive enzyme supplementation in functional dyspepsia: A monocentric, randomized, double-blind, placebo-controlled, clinical trial
PubMed ID: 37976892
Direct randomized evidence: multi‑enzyme supplementation improved dyspepsia symptom‑related QoL and reduced pain — strong support for gut comfort.
- Gastric peroral endoscopic myotomy versus botulinum toxin injection for the treatment of refractory gastroparesis: results of a double-blind randomized controlled study
PubMed ID: 38141620
G‑POEM increased gastric emptying rates versus botulinum injection—direct evidence of faster gastric meal transit in gastroparesis.
- Application of Recombinant Human Superoxide Dismutase in Radical Concurrent Chemoradiotherapy for Cervical Cancer to Prevent and Treat Radiation-induced Acute Rectal Injury: A Multicenter, Randomized, Open-label, Prospective Trial
PubMed ID: 38705489
rhSOD enemas greatly reduced diarrhea days and incidence of significant diarrhea—direct improvement in bowel regularity after radiotherapy.
- Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
PubMed ID: 38617446
AN‑PEP is a prolyl endopeptidase that enzymatically degrades gluten peptides—direct facilitation of food (gluten) breakdown.
- Functional Variation in Human CAZyme Genes in Relation to the Efficacy of a Carbohydrate-Restricted Diet in IBS Patients
PubMed ID: 39413891
Study specifically links human carbohydrate‑active enzyme (CAZyme) variation to diet response — directly relevant to the biological capability to break down food carbohydrates.
- A randomized controlled trial of environmental richness on gastrointestinal symptoms, salivary cortisol, and gut microbiota in early childhood
PubMed ID: 40075129
Nature‑based childcare randomized trial showed reduced GI symptom scores in children — direct human evidence of improved gut comfort (not an enzyme intervention but relevant symptom outcome).
- Biofeedback training versus botox injection for the treatment of dyssynergic defaecation: A randomized controlled trial
PubMed ID: 40329927
Randomized treatments (biofeedback/Botox) for dyssynergic defecation improved constipation scores and physiology — strong evidence for increased regularity (human RCT, not enzyme supplement).
- Enteral nutrition and pancreatic enzymes: a synergistic approach to enhance patient outcomes? A randomized controlled trial
PubMed ID: 41307649
RCT: pancreatic enzymes added to enteral nutrition slowed muscle-area loss—clinical evidence that enzyme supplementation improves nutrient use/digestion in critically ill.
- Pancreatic Enzyme Replacement Therapy Improves Exclusive Enteral Nutrition Related Diarrhea in Crohn's Disease: A Prospective Randomized Trial
PubMed ID: 40243170
Pancreatic enzyme replacement in Crohn’s directly improved stool frequency/consistency → clear digestion improvement.
- Starch Digestion-Related Amylase Genetic Variants, Diet, and Changes in Adiposity: Analyses in Prospective Cohort Studies and a Randomized Dietary Intervention
PubMed ID: 32493715
AMY1 copy number relates to salivary amylase activity important for starch breakdown.
- Endoscopic intragastric injection of botulinum toxin A in obese patients on bariatric surgery waiting lists: A randomised double-blind study (IntraTox study)
PubMed ID: 33092901
Endoscopic intragastric BTX improved GI‑related QoL (GIQLI) — clear improvement in gut comfort measures.
- Preventive Effect of High-Dose Digestive Enzyme Management on Development of Nonalcoholic Fatty Liver Disease after Pancreaticoduodenectomy: A Randomized Controlled Clinical Trial
PubMed ID: 32927075
High‑dose pancreatic enzyme therapy (including lipase) after PD dramatically reduced postoperative NAFLD and improved nutritional markers — strong evidence for improved/smoother fat digestion.
- Effects of Pancreatic Enzyme Replacement Therapy on Body Weight and Nutritional Assessments After Pancreatoduodenectomy in a Randomized Trial
PubMed ID: 31520730
Pancreatic enzyme replacement addresses pancreatic lipase deficiency and produced nutritional/weight benefits—strong support for fat digestion.
- Supplementation of Caricol®-Gastro reduces chronic gastritis disease associated pain
PubMed ID: 29604620
Papaya+oats enzyme supplement produced a significant additional reduction in gastritis pain vs placebo.
- Efficacy of actinidin-containing kiwifruit extract Zyactinase on constipation: a randomised double-blinded placebo-controlled clinical trial
PubMed ID: 29737803
Randomized trial reported significant increases in defecation frequency and improved stool form in mildly constipated adults.
- Evaluation of the Safety and Efficacy of a Multienzyme Complex in Patients with Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 30156436
Randomized RCT of a five‑enzyme supplement (DigeZyme®) showed large improvements in dyspepsia symptom scores, directly indicating improved digestion/upper GI symptoms.
- Combination of Gluten-Digesting Enzymes Improved Symptoms of Non-Celiac Gluten Sensitivity: A Randomized Single-blind, Placebo-controlled Crossover Study
PubMed ID: 30228265
Enzyme mix significantly reduced symptom scores in NCGS, consistent with improved gut comfort (bloating/incomplete evacuation symptoms).
- Exogenous protease supplementation of poultry by-product meal-based diets for broilers: Effects on growth, carcass characteristics and nutrient digestibility
PubMed ID: 28455873
Exogenous protease in poultry feed clearly improved nutrient digestibility—direct model evidence for improved digestion.
- Pancreatic Enzyme Replacement Therapy in Children with Severe Acute Malnutrition: A Randomized Controlled Trial
PubMed ID: 28912050
Pancreatic enzyme replacement in severely malnourished children improved clinical outcomes (lower mortality/faster discharge), consistent with restoration of digestive function.
- Recombinant Bile Salt-Stimulated Lipase in Preterm Infant Feeding: A Randomized Phase 3 Study
PubMed ID: 27244221
rhBSSL is a bile salt‑stimulated lipase intended to aid digestion of milk fats; infant trial showed subgroup feeding/growth benefit — direct dairy relevance.
- Effects of premedication with Pronase for endoscopic ultrasound of the stomach: A randomized controlled trial
PubMed ID: 28082820
Pronase (protease) mechanically digests gastric mucus/protein to improve imaging—demonstrates proteolytic breakdown activity in the stomach relevant to the concept of easier protein breakdown.
- Comparison of two pancreatic enzyme products for exocrine insufficiency in patients with cystic fibrosis
PubMed ID: 27013382
Direct randomized trial of pancreatic enzyme replacement (Zenpep) showing equivalent fat absorption to Kreon in EPI—strong human evidence of improved digestive function.
- Effects of Resistant Glucan Mixture on Bowel Movement in Female Volunteers
PubMed ID: 27117853
Resistant glucan (dietary fiber) increased defecation frequency and days in constipated women—clear evidence for more regular bowel function (not an enzyme product but relevant to digestion regularity).
- Effect of zinc bacitracin and phytase on growth performance, nutrient digestibility, carcass and meat traits of broilers
PubMed ID: 26608478
Broiler trial: bacterial phytase improved feed conversion and some fat digestibility measures—animal evidence for improved digestion parameters.
- Randomised clinical trial: a 1-week, double-blind, placebo-controlled study of pancreatin 25 000 Ph. Eur. minimicrospheres (Creon 25000 MMS) for pancreatic exocrine insufficiency after pancreatic surgery, with a 1-year open-label extension
PubMed ID: 23383603
Pancreatin produced large, statistically significant improvements in fat absorption and markedly reduced stool fat — direct strong evidence.
- [The role of small bowel microflora in the development of secondary lactase deficiency and the possibilities of its treatment with probiotics]
PubMed ID: 23653934
Probiotic therapy normalized lactase activity in ~70% of treated postinfectious IBS patients, directly aiding dairy digestion.
- Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children: a randomized, double-blind, placebo controlled trial
PubMed ID: 24063420
Placebo‑controlled pediatric trial: α‑galactosidase significantly reduced bloating severity, days with severe bloating and proportion with marked flatulence.
- [Lactase deficiency in patients with postinfectious irritable bowel syndrome and the role of intestinal microflora in its development]
PubMed ID: 23402179
Human study: probiotic restored lactase function and normalized breath tests in 71% with symptom improvement — directly demonstrates easier dairy digestion.
- Reintroduction of gluten following flour transamidation in adult celiac patients: a randomized, controlled clinical study
PubMed ID: 22899947
Enzymatic treatment of wheat reduced symptom relapse and early intestinal permeability in some celiac patients, directly improving gut-related symptoms.
- Effect of fibrolytic enzyme application to low- and high-concentrate diets on the performance of lactating dairy cattle
PubMed ID: 21257052
Fibrolytic enzyme sprayed on dairy rations increased dry‑matter and crude protein digestibility — supports improved digestion (animal model).
- [Influence of rhubarb on gastrointestinal motility and intestinal mucosal barrier in patients with severe burn]
PubMed ID: 22224253
Rhubarb+glutamine accelerated recovery of bowel function and motility markers in burn patients.
- Efficacy and safety of PANCREAZE® for treatment of exocrine pancreatic insufficiency due to cystic fibrosis
PubMed ID: 21632288
PANCREAZE directly maintained coefficient of fat absorption; primary evidence for smoother fat digestion.
- A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery
PubMed ID: 21418260
Creon pancrelipase in pancreatic insufficiency increased weight and reduced stool frequency—clear improvement in digestion.
- Effect of β-glucosidase on the meat quality and digestibility in broilers
PubMed ID: 21554407
Animal trial: supplemental β‑glucosidase in feed significantly increased protein and fat digestibility — direct evidence that exogenous enzymes can improve overall digestion (translational, not human).
- Effects of exogenous enzymes in corn-based and Canadian pearl millet-based diets with reduced soybean meal on growth performance, intestinal nutrient digestibility, villus development, and selected microbial populations in broiler chickens
PubMed ID: 21821810
Exogenous feed enzymes in broilers increased protein/amino‑acid digestibility—supports that added enzymes can enhance overall digestion (animal model).
- The effect on performance, energy metabolism and hepatic carotenoid content when phytase supplemented diets were fed to broiler chickens
PubMed ID: 20362312
High phytase greatly increased breakdown of phytate and improved nutrient release in chickens.
- Phosphorus utilization in starter pigs fed high-moisture corn-based liquid diets steeped with phytase
PubMed ID: 20729280
Phytase addition enhanced breakdown of phytate‑bound nutrients in pig diets.
- Multi-carbohydrase and phytase supplementation improves growth performance and liver insulin receptor sensitivity in broiler chickens fed diets containing full-fat rapeseed
PubMed ID: 20709979
Added carbohydrase/phytase improved feed substrate hydrolysis in chickens.
- Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial
PubMed ID: 20502447
Pancrelipase (enzyme replacement) markedly improved digestion in EPI patients.
- Effects of extrusion and supplementation of exogenous enzymes to diets containing Chinese storage brown rice on the carbohydrase activity in the digestive tract of piglets
PubMed ID: 20465715
Exogenous enzyme supplementation increased pancreatic and ileal carbohydrase activities and digestibility—strong evidence for easier food breakdown.
- Effect of probiotic on growth performance and digestive enzyme activity of Arbor Acres broilers
PubMed ID: 20350733
Broiler Bacillus coagulans increased protease and amylase activities and growth—supports enzyme‑driven digestion improvements.
- Use of Gascon and Pronase either as a pre-endoscopic drink or as targeted endoscopic flushes to improve visibility during gastroscopy: a prospective, randomized, controlled, blinded trial
PubMed ID: 20148732
Pronase (protease) actively digests mucous and debris improving mucosal clearing—illustrates proteolytic action in human GI tract.
- Interactions between xylanase and glucanase in maize-soy-based diets for broilers
PubMed ID: 20461586
Broiler trial: xylanase+glucanase improved ileal nutrient digestibility and feed efficiency—strong evidence for improved digestion.
- Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis
PubMed ID: 20512995
Human study explicitly shows GPB is hydrolyzed by pancreatic lipases (PTL/PLRP2/CEL)—direct evidence of lipase‑mediated hydrolysis supporting smoother fat digestion.
- P1A recombinant beta-lactamase prevents emergence of antimicrobial resistance in gut microflora of healthy subjects during intravenous administration of ampicillin
PubMed ID: 19307374
Oral beta‑lactamase prevented antibiotic‑induced flora disruption, reducing dysbiosis‑related discomfort—human data.
- Growth performance and nutrient digestibility in pigs fed wheat distillers dried grains with solubles-based diets supplemented with a multicarbohydrase enzyme
PubMed ID: 19359515
Animal trial: exogenous carbohydrases improved apparent digestibility in pigs—direct support for improved digestion.
- Enzyme complex containing carbohydrases and phytase improves growth performance and bone mineralization of broilers fed reduced nutrient corn-soybean-based diets
PubMed ID: 19687277
Carbohydrase+phytase improved feed intake/gain in broilers, consistent with improved digestion (animal).
- The efficacy of Combizym in the treatment of Chinese patients with dyspepsia: a multicenter, randomized, placebo-controlled and cross-over study: Shanghai Combizym Clinical Cooperative Group
PubMed ID: 19236546
Combizym (digestive‑enzyme product) RCT markedly reduced dyspepsia symptoms — direct evidence of improved digestion.
- The effect of a multispecies probiotic on the intestinal microbiota and bowel movements in healthy volunteers taking the antibiotic amoxycillin
PubMed ID: 17900321
Probiotic reduced incidence of diarrhea‑like stools during antibiotics in healthy volunteers — direct evidence for more regular bowel function (microbial approach).
- Efficacy and equivalency of an Escherichia coli-derived phytase for replacing inorganic phosphorus in the diets of broiler chickens and young pigs
PubMed ID: 17093229
Animal feed phytase improved apparent nutrient digestibility and growth — directly supports improved digestion (mechanistic relevance).
- Impaired gastric myoelectricity in patients with chronic pancreatitis: role of maldigestion
PubMed ID: 15637747
Enzyme replacement normalized gastric slow-wave activity, indicating more regular gastric rhythm and digestion.
- Effects of beta-glucanase-producing Lactobacillus strains on growth, dry matter and crude protein digestibilities and apparent metabolisable energy in broiler chickens
PubMed ID: 16050187
Chickens fed Lactobacillus producing beta‑glucanase had substantially better digestibility (AME, protein, dry matter) — direct evidence of improved digestion (animal model).
- [Benefits of a thickened infant formula with lactase activity in the management of benign digestive disorders in newborns]
PubMed ID: 15596352
Randomized double-blind trial: lactase-containing formula specifically reduced symptoms related to lactose intolerance (gas, regurgitation) in infants.
- Lipase inhibition by orlistat: effects on gall-bladder kinetics and cholecystokinin release in obesity
PubMed ID: 14987329
Orlistat (lipase inhibitor) produced marked, dose-dependent impairment of gallbladder emptying and reduced CCK, strongly implicating lipase in smooth fat digestion.
- Occlusion of the pancreatic duct versus pancreaticojejunostomy: a prospective randomized trial
PubMed ID: 12368670
Surgical study directly addressing pancreatic exocrine function — relevant to capacity for digestion (supports need/role of enzymes).
- Randomized controlled study of digestive enzyme activity following trophic feeding
PubMed ID: 12022301
Trophic early milk feeds increased intestinal lactase activity in very preterm infants, directly supporting improved dairy (lactose) digestion.
- [Dose-dependent effect of pancreatin replacement upon the pancreatic function in the period after pancreatic surgery]
PubMed ID: 11816130
Enteric-coated pancreatin after pancreatic surgery produced large, dose-dependent improvements in digestion tests and resolved maldigestion symptoms in humans.
- Comparison of pantoprazole 20 mg to ranitidine 150 mg b.i.d. in the treatment of mild gastroesophageal reflux disease
PubMed ID: 11351143
Pantoprazole provided faster symptom relief for reflux/heartburn vs ranitidine, representing rapid mealtime symptom improvement (clinical RCT evidence).
- Esomeprazole once daily for 6 months is effective therapy for maintaining healed erosive esophagitis and for controlling gastroesophageal reflux disease symptoms: a randomized, double-blind, placebo-controlled study of efficacy and safety
PubMed ID: 11197282
PPI therapy markedly reduced heartburn and maintained esophagitis healing—strongly improves mealtime comfort when acid is causal.
- Effects on 24-hour intragastric pH: a comparison of lansoprazole administered nasogastrically in apple juice and pantoprazole administered intravenously
PubMed ID: 11467632
Sustained intragastric pH elevation with lansoprazole is associated with improved meal-time comfort (indirect to enzymes).
- Amylase-resistant starch plus oral rehydration solution for cholera
PubMed ID: 10655529
Resistant starch in ORS significantly reduced stool output and shortened diarrhea duration—clinically improves gut comfort in cholera.
- [Effect of pancreatin replacement on pancreatic function in the postoperative period after pancreatic surgery]
PubMed ID: 10628192
Randomized trial: enteric‑coated pancreatin improved amylum tolerance and eliminated maldigestion symptoms after pancreatic surgery.
- Effects of beano on the tolerability and pharmacodynamics of acarbose
PubMed ID: 9663365
Alpha‑galactosidase (Beano) reduced flatulence and breath hydrogen when coadministered with acarbose—improves gut comfort related to gas.
- Early feeding, feeding tolerance, and lactase activity in preterm infants
PubMed ID: 9821422
Early enteral feeding doubled lactase activity and improved feeding outcomes → direct, strong evidence for easier dairy digestion.
- Enteral versus parenteral nutrition: effects on gastrointestinal function and metabolism
PubMed ID: 8838831
Enteral (vs parenteral) feeding preserved GI function and improved visceral protein synthesis—supports maintained digestion.
- Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy--Italian Group
PubMed ID: 8786777
IV gabexate reduced abdominal pain and post‑ERCP pancreatitis incidence—clinically meaningful gut comfort benefit in that setting.
- Long-term prophylactic administration of octreotide reduces the rise in serum amylase after endoscopic procedures on Vater's papilla
PubMed ID: 8783335
Octreotide markedly reduced epigastric pain after ERCP, giving relatively rapid symptomatic relief in that setting.
- Activities of trypsin and lipase in duodenal aspirates of preterm infants: influence of dietary protein and fat composition
PubMed ID: 7872215
Feeding fat composition altered duodenal lipase, linking diet to fat‑digesting enzyme activity.
- Thermophilic amylase-digested rice-electrolyte solution in the treatment of acute diarrhea in children
PubMed ID: 7530834
Thermophilic amylase ORS shortened diarrhea and improved feeding outcomes — direct digestion benefit in children.
- Improved energy intakes using amylase-digested weaning foods in Tanzanian children with acute diarrhea
PubMed ID: 8576819
Amylase‑digested porridge allowed more rapid energy uptake (higher intake and absorption) in children.
- Effects of pancreatic digestive enzymes, sodium bicarbonate, and a proton pump inhibitor on steatorrhoea caused by pancreatic diseases
PubMed ID: 7774757
Direct trial: pancreatic enzyme supplements markedly reduced faecal fat vs alternatives — strong evidence for improved fat digestion.
- Oral bacteriotherapy for viral gastroenteritis
PubMed ID: 7995184
Lactobacillus GG shortened rotavirus diarrhea and altered stool enzymes — clinical gut comfort benefit in pediatrics.
- Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: a randomized controlled trial
PubMed ID: 17060763
Perioperative synbiotics increased beneficial fecal bifidobacteria and reduced postoperative infections and inflammatory markers — supports improved gut-related comfort/health.
- Nitrogen retention, energy, and amino acid digestibility of wheat bran, without or with multicarbohydrase and phytase supplementation, fed to broiler chickens
PubMed ID: 29746701
Feed carbohydrase+phytase increased amino acid digestibility and energy extraction in poultry — supports enzymatic aid to breakdown (animal data).
- Avoidance of Cow's Milk-Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial
PubMed ID: 28687275
Study of extensively hydrolyzed casein vs conventional formula (dairy protein pre-digestion) — directly relevant to easier dairy protein digestion.
- Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder-A Randomized, Controlled 12-Month Trial
PubMed ID: 29562612
Multi-component program including digestive enzymes reduced GI symptom scores in people with ASD, but effect cannot be attributed solely to enzymes (human).
- Effects of zinc oxide and microbial phytase on digestibility of calcium and phosphorus in maize-based diets fed to growing pigs
PubMed ID: 28380588
Pig study: microbial phytase increased Ca/P digestibility and retention, indicating improved digestive function for minerals.
- Effects of phytase supplementation on growth performance, jejunum morphology, liver health, and serum metabolites of Japanese quails fed sesame (Sesamum indicum) meal-based diets containing graded levels of protein
PubMed ID: 27113452
Quail trial: phytase increased serum minerals and improved gut morphology and feed efficiency, supporting improved digestion.
- Modulation of small intestinal phosphate transporter by dietary supplements of mineral phosphorus and phytase in broilers
PubMed ID: 25834252
Mechanistic chicken study: phytase altered intestinal transporter expression consistent with altered digestive handling of P/Ca.
- Effects of microbial phytase on apparent and standardized total tract digestibility of calcium in calcium supplements fed to growing pigs
PubMed ID: 26020322
Pig trial showing increased apparent/standardized digestibility of Ca and P with phytase — direct evidence of improved digestion of key nutrients.
- Improving lactose digestion and symptoms of lactose intolerance with a novel galacto-oligosaccharide (RP-G28): a randomized, double-blind clinical trial
PubMed ID: 24330605
RP‑G28 increased self‑reported lactose tolerance and reduced abdominal pain in lactose‑intolerant adults — strong human evidence for easier dairy digestion (prebiotic approach).
- Assessment of a bacterial 6-phytase in the diets of broiler chickens
PubMed ID: 23873558
Bacterial 6‑phytase improved growth and mineral/utilization in broilers — supports improved digestion (animal).
- Endogenous intestinal losses of calcium and true total tract digestibility of calcium in canola meal fed to growing pigs
PubMed ID: 23942713
Microbial phytase increased Ca and P digestibility and reduced fecal P in pigs — enzyme-enhanced digestion (animal).
- Phytase improves apparent total tract digestibility of phosphorus and calcium in piglets fed diets with adequate or reduced phosphorus content
PubMed ID: 23365327
Thermotolerant 6‑phytase improved ATTD phosphorus and Ca and improved feed efficiency.
- The supplementation of low-P diets with microbial 6-phytase expressed in Aspergillus oryzae increases P and Ca digestibility in growing pigs
PubMed ID: 23365288
Microbial phytase increased total tract P digestibility from ~29%→62% (strong enzyme effect).
- Growth performance, diet nutrient digestibility, and bone mineralization in weaned pigs fed pelleted diets containing thermostable phytase
PubMed ID: 23148255
Thermostable phytase improved P digestibility and growth efficiency in weaned pigs.
- Comparative effects of three phytases on the phosphorus and calcium use in the weaned piglet
PubMed ID: 23365294
(duplicate entry) See above: microbial phytases improved mineral utilisation.
- Performance and apparent total tract phosphorus and calcium digestibility in grower-finisher pigs fed diets with and without phytase
PubMed ID: 23365310
Thermotolerant phytase restored digestibility and growth when dietary P/Ca reduced — strong restoration of digestive efficiency (animal).
- Effect of reduced dietary calcium concentration and phytase supplementation on calcium and phosphorus utilization in weanling pigs with modified mineral status
PubMed ID: 20118415
Weanling pig phytase markedly increased P digestibility — direct digestive-enzyme effect (animal).
- Effect of exogenous enzymes in maize-based diets varying in nutrient density for young broilers: growth performance and digestibility of energy, minerals and amino acids
PubMed ID: 18210288
Xylanase–amylase–protease cocktail directly assists breakdown of complex feed components, improving digestibility in broilers (animal).
- Influence of enzyme supplementation of maize-soyabean meal diets on carcase composition, whole-body nutrient accretion and total tract nutrient retention of broilers
PubMed ID: 18704790
Exogenous enzyme mixes increased nutrient accretion and retention in broilers via improved breakdown of feed components (animal).
- Effect of Dewaxed Coffee on Gastroesophageal Symptoms in Patients with GERD: A Randomized Pilot Study
PubMed ID: 35745239
Dewaxed coffee led to fewer reflux/heartburn days and better GI QoL — strong evidence for improved mealtime comfort in coffee‑sensitive GERD patients.
- Enzyme supplementation to improve the nutritional value of fibrous feed ingredients in swine diets fed in dry or liquid form
PubMed ID: 27065265
Xylanase increased ileal digestibility of energy and fiber markedly in pigs.
- Phytase modulates ileal microbiota and enhances growth performance of the broiler chickens
PubMed ID: 25781608
Dietary phytase improved growth/feed efficiency and altered gut metabolites in broilers.
- Lupin kernel fibre foods improve bowel function and beneficially modify some putative faecal risk factors for colon cancer in men
PubMed ID: 16469156
Lupin kernel fiber increased stool bulk and sped transit in humans → supports more regular digestion.
- Effect of an organized lipid matrix on lipid absorption and clinical outcomes in patients with cystic fibrosis
PubMed ID: 12183711
Organized lipid matrix produced large improvements in fat absorption and fat‑soluble vitamin status in CF—strong support for improved fat digestion/handling.
- Effect of wheat dried distillers grains with solubles and fibrolytic enzymes on ruminal fermentation, digestibility, growth performance, and feeding behavior of beef cattle
PubMed ID: 26020898
Fibrolytic enzyme supplementation in beef cattle increased fiber and CP digestibility—supports enzyme-driven improvement in digestive breakdown (animal study).
- Using a fibrolytic enzyme in barley-based diets containing wheat dried distillers grains with solubles: ruminal fermentation, digestibility, and growth performance of feedlot steers
PubMed ID: 24987082
A fibrolytic enzyme applied to cattle diets enhanced starch digestion and overall digestibility—strong evidence that added enzymes improve digestion in feed systems.
- Effect of microbial phytase on phosphorus digestibility in non-heat-treated and heat-treated wheat-barley pig diets
PubMed ID: 23365331
Microbial phytase added to pig diets measurably increased phosphorus apparent digestibility—direct evidence exogenous enzyme improves digestion (animal model).
- Wheat-barley-rye- or corn-fed growing pigs respond differently to dietary supplementation with a carbohydrase complex
PubMed ID: 22345107
Carbohydrase is a digestive enzyme; the study shows direct improvement in breakdown/digestibility of carbohydrates.
- Improved milk production efficiency in early lactation dairy cattle with dietary addition of a developmental fibrolytic enzyme additive
PubMed ID: 21257058
Fibrolytic enzyme increased fiber disappearance and production efficiency in cows—direct evidence enzyme supplementation can improve breakdown/digestion (animal model).
- Effect of direct-fed fibrolytic enzymes on the lactational performance of dairy cows
PubMed ID: 10194681
Exogenous fibrolytic enzymes sprayed on forage improved feed digestibility in dairy cows (clear digestion benefit).
- Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome
PubMed ID: 28724171
Beta‑glucan + inositol + digestive enzymes decreased bloating, gas and abdominal pain and improved well‑being in IBD patients with IBS symptoms — clear improvement in gut comfort.
- Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis: A Randomized Placebo-Controlled Trial
PubMed ID: 26465792
LXS intervention in CF significantly improved coefficient of fat absorption and reduced prevalence of low CFA — direct evidence of improved fat digestion/absorption in humans.
- Interactions between supplemented mineral phosphorus and phytase on phytate hydrolysis and inositol phosphates in the small intestine of broilers1,2
PubMed ID: 25810408
High‑dose phytase nearly completely hydrolyzed phytate in broilers, directly demonstrating stronger digestive breakdown.
- Effects of microbial phytase on the apparent and standardized total tract digestibility of phosphorus in rice coproducts fed to growing pigs
PubMed ID: 26440013
Microbial phytase in pigs increased phosphorus digestibility (ATTD/STTD), indicating improved digestion of phytate-bound nutrients.
- Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit
PubMed ID: 23911555
Faecal pancreatic protease activity rose with faster transit; data directly link pancreatic enzymes to more rapid intestinal transit in IBS‑D (observational).
- The effect of microbial phytase and myo-inositol on performance and blood biochemistry of broiler chickens fed wheat/corn-based diets
PubMed ID: 23873561
Phytase/myo-inositol in broilers improved growth and feed conversion, implying better digestive utilization of feed with enzyme addition.
- Antioxidant protective effects of lactitol against endotoxemia in patients with chronic viral hepatitis
PubMed ID: 23165913
Lactitol (prebiotic) in adults with chronic hepatitis reduced endotoxin and oxidative stress and increased beneficial bacteria — consistent with improved gut environment/comfort.
- Effect of beta-glucan, inositol and digestive enzymes in GI symptoms of patients with IBS
PubMed ID: 21796867
Biointol (contains digestive enzymes) reduced bloating, flatulence and abdominal pain in IBS patients — direct symptomatic improvement indicating better gut comfort.
- Effect of dietary phytate and phytase on metabolic change of blood and intestinal mucosa in chickens
PubMed ID: 19906143
Phytase in broilers corrected phytate-associated impairments in metabolism and nutrient markers, indicating enhanced breakdown of feed components (animal evidence).
- Escherichia coli phytase improves growth performance of starter, grower, and finisher pigs fed phosphorus-deficient diets
PubMed ID: 16024708
Phytase added to pig diets improved growth/feed efficiency and mineral absorption, showing exogenous enzyme improves digestive processing in animals.
- Is a proton pump inhibitor necessary for the treatment of lower-grade reflux esophagitis?
PubMed ID: 10452673
Effective treatment of reflux esophagitis with PPI reduces heartburn and related mealtime discomfort — strong symptomatic relevance though not an enzyme therapy.
- Dietary management of acute diarrhoea in children: effect of fermented and amylase-digested weaning foods on intestinal permeability
PubMed ID: 9138166
Amylase‑digested, fermented porridge accelerated intestinal barrier recovery and clinical improvement in children.
- Effects of lactulose and lactitol on colonic microflora and enzymatic activity
PubMed ID: 9145445
Lactulose/lactitol altered microbiota and increased fermentation, promoting more regular bowel function.
- Standardized parenteral alanyl-glutamine dipeptide supplementation is not beneficial in autologous transplant patients: a randomized, double-blind, placebo controlled study
PubMed ID: 12476290
IV alanyl‑glutamine reduced diarrhea — clear gut symptom benefit
- Probiotic Lactobacillus fermentum TSF331, Lactobacillus reuteri TSR332, and Lactobacillus plantarum TSP05 improved liver function and uric acid management-A pilot study
PubMed ID: 39046973
Probiotic supplementation improved gut‑related metrics and shifted microbiota; plausible moderate benefit to gut comfort.
Nutrient uptake (88)
- Effects of exogenous enzymes in corn-based and Canadian pearl millet-based diets with reduced soybean meal on growth performance, intestinal nutrient digestibility, villus development, and selected microbial populations in broiler chickens
PubMed ID: 21821810
Exogenous enzymes improved apparent ileal digestibility of protein and amino acids in broilers—supports improved nutrient absorption (animal).
- The effect on performance, energy metabolism and hepatic carotenoid content when phytase supplemented diets were fed to broiler chickens
PubMed ID: 20362312
High‑dose phytase raised growth and nutrient retention in chickens.
- Phosphorus utilization in starter pigs fed high-moisture corn-based liquid diets steeped with phytase
PubMed ID: 20729280
Phytase in pigs improved protein and dry‑matter digestibility and mineral retention.
- Multi-carbohydrase and phytase supplementation improves growth performance and liver insulin receptor sensitivity in broiler chickens fed diets containing full-fat rapeseed
PubMed ID: 20709979
Phytase/carbohydrase improved feed nutrient uptake in broilers.
- Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial
PubMed ID: 20502447
Pancrelipase greatly improved fat and nitrogen absorption vs placebo.
- Effects of extrusion and supplementation of exogenous enzymes to diets containing Chinese storage brown rice on the carbohydrase activity in the digestive tract of piglets
PubMed ID: 20465715
Exogenous enzymes increased ileal carbohydrase activity and digestibility in piglets—strong support for improved nutrient absorption.
- Effect of probiotic on growth performance and digestive enzyme activity of Arbor Acres broilers
PubMed ID: 20350733
Probiotic increased protease/amylase activities in broilers and improved growth—supports enzymatic enhancement of nutrient digestion/absorption.
- Interactions between xylanase and glucanase in maize-soy-based diets for broilers
PubMed ID: 20461586
Xylanase+glucanase improved ileal nutrient digestibility and amino acid digestibility in broilers—strong support for improved absorption.
- Growth performance and nutrient digestibility in pigs fed wheat distillers dried grains with solubles-based diets supplemented with a multicarbohydrase enzyme
PubMed ID: 19359515
Pig diets with carbohydrase improved apparent total tract and ileal digestibility (DM, N, GE)—direct evidence of improved absorption.
- Enzyme complex containing carbohydrases and phytase improves growth performance and bone mineralization of broilers fed reduced nutrient corn-soybean-based diets
PubMed ID: 19687277
Carbohydrase+phytase substantially improved feed efficiency in broilers — consistent with improved nutrient absorption (animal evidence).
- The efficacy of Combizym in the treatment of Chinese patients with dyspepsia: a multicenter, randomized, placebo-controlled and cross-over study: Shanghai Combizym Clinical Cooperative Group
PubMed ID: 19236546
Combizym improved dyspepsia symptoms; improved digestion can reasonably improve nutrient absorption (indirect evidence).
- Efficacy and equivalency of an Escherichia coli-derived phytase for replacing inorganic phosphorus in the diets of broiler chickens and young pigs
PubMed ID: 17093229
Phytase increased apparent phosphorus (and other nutrient) digestibility in broilers/pigs — strong, direct evidence for improved nutrient absorption (animal data).
- Effects of beta-glucanase-producing Lactobacillus strains on growth, dry matter and crude protein digestibilities and apparent metabolisable energy in broiler chickens
PubMed ID: 16050187
Animal study showed increased apparent metabolisable energy and higher crude protein/dry matter digestibility — indicates improved nutrient absorption.
- [Dose-dependent effect of pancreatin replacement upon the pancreatic function in the period after pancreatic surgery]
PubMed ID: 11816130
Pancreatin improved amylum tolerance and prevented weight loss after pancreatic surgery—consistent with better macronutrient digestion/absorption.
- [Effect of pancreatin replacement on pancreatic function in the postoperative period after pancreatic surgery]
PubMed ID: 10628192
Improved amylum tolerance and prevention of postoperative weight loss imply better digestion/absorption with pancreatin.
- Early feeding, feeding tolerance, and lactase activity in preterm infants
PubMed ID: 9821422
Increased lactase activity in preterms led to faster feeding tolerance → better digestion and likely improved carbohydrate absorption.
- Enteral versus parenteral nutrition: effects on gastrointestinal function and metabolism
PubMed ID: 8838831
Enteral feeding improved visceral protein synthesis and nutritional indices vs parenteral feeding.
- Activities of trypsin and lipase in duodenal aspirates of preterm infants: influence of dietary protein and fat composition
PubMed ID: 7872215
Duodenal lipase varied with feed composition, linking enzyme levels to fat digestion/absorption.
- Thermophilic amylase-digested rice-electrolyte solution in the treatment of acute diarrhea in children
PubMed ID: 7530834
Amylase‑digested rice ORS reduced diarrhea and improved weight gain — supports better nutrient retention/absorption.
- Improved energy intakes using amylase-digested weaning foods in Tanzanian children with acute diarrhea
PubMed ID: 8576819
Amylase‑digested porridge increased energy intake by ~42%, indicating better caloric uptake/absorption.
- Effects of pancreatic digestive enzymes, sodium bicarbonate, and a proton pump inhibitor on steatorrhoea caused by pancreatic diseases
PubMed ID: 7774757
Pancreatic enzymes reduced fecal fat excretion, indicating improved fat absorption.
- Efficacy of early postoperative enteral nutrition in supporting patients after esophagectomy
PubMed ID: 24504222
Early enteral feeding reduced gut-permeability markers and improved nutritional status post-op; indirect evidence.
- Lysozyme as an alternative to antibiotics improves growth performance and small intestinal morphology in nursery pigs
PubMed ID: 23572262
Lysozyme improved jejunal morphology (villus height:crypt depth), consistent with better absorptive capacity.
- Nitrogen retention, energy, and amino acid digestibility of wheat bran, without or with multicarbohydrase and phytase supplementation, fed to broiler chickens
PubMed ID: 29746701
Multi‑enzyme supplementation in broilers increased standardized ileal digestibility of amino acids and apparent metabolizable energy — improved nutrient uptake (animal data).
- Effects of zinc oxide and microbial phytase on digestibility of calcium and phosphorus in maize-based diets fed to growing pigs
PubMed ID: 28380588
Dose–response pig study: phytase increased Ca/P ATTD and retention markedly and offset negative ZnO effects — strong support for enhanced mineral absorption.
- Effects of phytase supplementation on growth performance, jejunum morphology, liver health, and serum metabolites of Japanese quails fed sesame (Sesamum indicum) meal-based diets containing graded levels of protein
PubMed ID: 27113452
Large quail trial: enzyme addition increased serum Ca and P and improved feed conversion, consistent with improved mineral absorption.
- Modulation of small intestinal phosphate transporter by dietary supplements of mineral phosphorus and phytase in broilers
PubMed ID: 25834252
Phytase altered intestinal phosphate/calcium transporter protein expression in chickens, a mechanistic basis for changed mineral absorption.
- Effects of microbial phytase on apparent and standardized total tract digestibility of calcium in calcium supplements fed to growing pigs
PubMed ID: 26020322
Well-controlled pig trial: microbial phytase significantly increased measured Ca and P digestibility (direct evidence for improved nutrient absorption).
- Assessment of a bacterial 6-phytase in the diets of broiler chickens
PubMed ID: 23873558
Bacterial phytase increased P and Ca retention and phytic acid disappearance — supports improved mineral absorption (animal).
- Endogenous intestinal losses of calcium and true total tract digestibility of calcium in canola meal fed to growing pigs
PubMed ID: 23942713
Microbial phytase increased true total tract Ca digestibility and reduced fecal P — improved mineral absorption (animal).
- Phytase improves apparent total tract digestibility of phosphorus and calcium in piglets fed diets with adequate or reduced phosphorus content
PubMed ID: 23365327
Thermotolerant 6‑phytase increased ATTD phosphorus (48%→61–68% with FTU doses).
- The supplementation of low-P diets with microbial 6-phytase expressed in Aspergillus oryzae increases P and Ca digestibility in growing pigs
PubMed ID: 23365288
Phytase increased ATTD phosphorus from ~29%→62% (large improvement in absorption).
- Growth performance, diet nutrient digestibility, and bone mineralization in weaned pigs fed pelleted diets containing thermostable phytase
PubMed ID: 23148255
Thermostable phytase improved phosphorus digestibility and growth efficiency.
- Comparative effects of three phytases on the phosphorus and calcium use in the weaned piglet
PubMed ID: 23365294
Different commercial phytases improved P and Ca utilisation in weaned piglets.
- Performance and apparent total tract phosphorus and calcium digestibility in grower-finisher pigs fed diets with and without phytase
PubMed ID: 23365310
Thermotolerant phytase restored ATTD of phosphorus toward control levels — strong nutrient absorption improvement (animal).
- Effect of reduced dietary calcium concentration and phytase supplementation on calcium and phosphorus utilization in weanling pigs with modified mineral status
PubMed ID: 20118415
Phytase substantially raised phosphorus digestibility and affected Ca/P balance in pigs — clear absorption gains (animal).
- Effect of exogenous enzymes in maize-based diets varying in nutrient density for young broilers: growth performance and digestibility of energy, minerals and amino acids
PubMed ID: 18210288
Xylanase/amylase/protease improved metabolisable energy and nitrogen retention — evidence of better macronutrient utilization (animal).
- Influence of enzyme supplementation of maize-soyabean meal diets on carcase composition, whole-body nutrient accretion and total tract nutrient retention of broilers
PubMed ID: 18704790
Exogenous enzymes increased body nutrient accumulation and retention in broilers — supports enhanced absorption/utilization (animal).
- Enzyme supplementation to improve the nutritional value of fibrous feed ingredients in swine diets fed in dry or liquid form
PubMed ID: 27065265
Xylanase increased ileal digestibility of gross energy and NDF substantially in pigs.
- Phytase modulates ileal microbiota and enhances growth performance of the broiler chickens
PubMed ID: 25781608
Phytase improved growth and altered gut metabolites and ileal microbiota; improved nutrient utilisation.
- Tryptophan, glutamine, leucine, and micronutrient supplementation improves environmental enteropathy in Zambian adults: a randomized controlled trial
PubMed ID: 31504110
Amino‑acid supplementation improved villus height and reduced barrier leak in enteropathy → supports improved absorptive capacity (indirect).
- Effect of an organized lipid matrix on lipid absorption and clinical outcomes in patients with cystic fibrosis
PubMed ID: 12183711
Organized lipid matrix substantially increased fat (retinyl palmitate/TG) AUC and improved fat‑soluble vitamin status in CF—strong fat‑absorption benefit.
- Effect of wheat dried distillers grains with solubles and fibrolytic enzymes on ruminal fermentation, digestibility, growth performance, and feeding behavior of beef cattle
PubMed ID: 26020898
Enzyme increased CP/NDF disappearance and total tract digestibility, implying better nutrient extraction/absorption in ruminants.
- Using a fibrolytic enzyme in barley-based diets containing wheat dried distillers grains with solubles: ruminal fermentation, digestibility, and growth performance of feedlot steers
PubMed ID: 24987082
Fibrolytic enzyme improved starch digestibility and reduced ruminal NH3-N, consistent with improved nutrient utilization/availability.
- Effect of microbial phytase on phosphorus digestibility in non-heat-treated and heat-treated wheat-barley pig diets
PubMed ID: 23365331
Increased phosphorus ATTD with microbial phytase indicates improved mineral availability/absorption in the animal model.
- Wheat-barley-rye- or corn-fed growing pigs respond differently to dietary supplementation with a carbohydrase complex
PubMed ID: 22345107
Carbohydrase increased site-specific digestibility and villus height in pigs, supporting improved nutrient uptake.
- Growth performance and nutrient digestibilities in nursery pigs receiving varying doses of xylanase and β-glucanase blend in pelleted wheat- and barley-based diets
PubMed ID: 23365293
Supplemental xylanase/β‑glucanase increased apparent ileal digestibility of DM/CP/energy/AA in pigs (animal evidence of improved absorption).
- Improved milk production efficiency in early lactation dairy cattle with dietary addition of a developmental fibrolytic enzyme additive
PubMed ID: 21257058
Enhanced fiber digestibility and efficiency in lactating cows implies improved breakdown and potential nutrient availability (animal evidence).
- Effect of direct-fed fibrolytic enzymes on the lactational performance of dairy cows
PubMed ID: 10194681
Enzyme treatment of forage improved feed digestibility and intake, consistent with improved nutrient availability.
- Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis: A Randomized Placebo-Controlled Trial
PubMed ID: 26465792
Human RCT in children with CF showed LXS significantly improved coefficient of fat absorption and plasma/muscle choline — clear absorption benefit in humans.
- Interactions between supplemented mineral phosphorus and phytase on phytate hydrolysis and inositol phosphates in the small intestine of broilers1,2
PubMed ID: 25810408
Phytase markedly increased InsP6 hydrolysis and net phosphorus absorption in broilers (direct nutrient absorption evidence).
- Effects of microbial phytase on the apparent and standardized total tract digestibility of phosphorus in rice coproducts fed to growing pigs
PubMed ID: 26440013
Microbial phytase increased apparent and standardized total tract phosphorus digestibility in growing pigs (direct absorption benefit).
- The effect of microbial phytase and myo-inositol on performance and blood biochemistry of broiler chickens fed wheat/corn-based diets
PubMed ID: 23873561
Phytase/myo-inositol increased growth and feed efficiency in broilers, consistent with improved nutrient utilization/absorption.
- Effect of dietary phytate and phytase on metabolic change of blood and intestinal mucosa in chickens
PubMed ID: 19906143
In broiler chickens, phytase largely corrected phytate-associated reductions in serum proteins, minerals and antioxidant markers, consistent with improved nutrient absorption and utilization (strong animal evidence).
- Escherichia coli phytase improves growth performance of starter, grower, and finisher pigs fed phosphorus-deficient diets
PubMed ID: 16024708
E. coli phytase produced linear increases in plasma phosphorus and daily P absorption in pigs — strong evidence enzyme enhances mineral absorption.
- Effects of enteral supplementation with glutamine granules on intestinal mucosal barrier function in severe burned patients
PubMed ID: 15019120
Oral glutamine improved intestinal barrier markers (L/M ratio, DAO) in burn patients, which plausibly improves nutrient absorption (indirect, not an enzyme supplement).
- Dietary management of acute diarrhoea in children: effect of fermented and amylase-digested weaning foods on intestinal permeability
PubMed ID: 9138166
Enzyme‑predigested food improved intestinal barrier/permeability and likely nutrient uptake in children with diarrhea.
- Teduglutide improves liver chemistries in short bowel syndrome-associated intestinal failure: Post hoc analysis
PubMed ID: 38491966
Teduglutide enhances intestinal absorption/adaptation in short bowel syndrome (directly improves absorption).
- Safety and Efficacy of N-SORB(®), a Proprietary KD120 MEC Metabolically Activated Enzyme Formulation: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 30971174
Multienzyme product could plausibly aid absorption; study reported QoL but did not measure absorption directly.
- Effect of β-glucosidase on the meat quality and digestibility in broilers
PubMed ID: 21554407
Broiler study showed increased protein and fat digestibility with added β‑glucosidase — directly supports improved nutrient extraction/absorption (animal model).
- A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery
PubMed ID: 21418260
Creon pancrelipase increased body weight and reduced stool frequency in enzyme‑deficient patients, consistent with improved absorption.
- Efficacy and safety of PANCREAZE® for treatment of exocrine pancreatic insufficiency due to cystic fibrosis
PubMed ID: 21632288
PANCREAZE preserved coefficient of fat absorption (CFA) vs placebo withdrawal (~34% drop on placebo) — direct evidence of improved nutrient absorption.
- Effect of fibrolytic enzyme application to low- and high-concentrate diets on the performance of lactating dairy cattle
PubMed ID: 21257052
Fibrolytic enzyme increased CP and fiber digestibility in dairy cows — implies greater nutrient availability/absorption (animal model).
- Enzyme effects on extruded diets for dogs with soybean meal as a substitute for poultry by-product meal
PubMed ID: 23639016
Enzyme supplementation in dog diets tended to reduce post‑prandial urea (better protein utilization) and increased SCFA — supports absorption/utilization.
- [The role of small bowel microflora in the development of secondary lactase deficiency and the possibilities of its treatment with probiotics]
PubMed ID: 23653934
Probiotic restored lactase activity in many post‑infectious IBS patients, normalizing lactose digestion/absorption.
- Randomised clinical trial: a 1-week, double-blind, placebo-controlled study of pancreatin 25 000 Ph. Eur. minimicrospheres (Creon 25000 MMS) for pancreatic exocrine insufficiency after pancreatic surgery, with a 1-year open-label extension
PubMed ID: 23383603
Pancreatin produced large, significant increases in fat and nitrogen absorption (CFA/CNA) in humans.
- Xylanase supplementation of a wheat-based diet improved nutrient digestion and mRNA expression of intestinal nutrient transporters in broiler chickens infected with Clostridium perfringens
PubMed ID: 24570428
Xylanase increased apparent metabolizable energy and ileal crude-protein digestibility in broilers, consistent with improved nutrient uptake (animal study).
- Effects of dietary supplementation of multi-enzyme on growth performance, nutrient digestibility, small intestinal digestive enzyme activities, and large intestinal selected microbiota in weanling pigs
PubMed ID: 24663197
Multi-enzyme supplementation raised apparent total tract digestibility (DM/CP/GE) in piglets—direct surrogate for better nutrient absorption.
- The effect of oral pancreatic enzyme supplementation on the course and outcome of acute pancreatitis: a randomized, double-blind parallel-group study
PubMed ID: 24618443
Pancreatic enzyme supplementation during recovery from pancreatitis would be expected to improve digestion of fats/proteins and thus absorption; study showed faster recovery.
- Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease
PubMed ID: 24583059
By preventing gluten‑induced mucosal damage ALV003 preserves villus architecture and thus nutrient absorption in celiac patients.
- Apparent and standardized total tract digestibility by growing pigs of phosphorus in canola meal from North America and 00-rapeseed meal and 00-rapeseed expellers from Europe without and with microbial phytase
PubMed ID: 26440018
Phytase markedly improved phosphorus digestibility (ATTD/STTD) — direct evidence of better mineral/nutrient absorption in animals.
- Continual feeding of two types of microalgal biomass affected protein digestion and metabolism in laying hens
PubMed ID: 25568377
Exogenous protease improved ileal amino acid digestibility in hens — direct evidence for improved protein nutrient absorption (animal model).
- Energy utilization and growth performance of chickens fed novel wheat inbred lines selected for different pentosan levels with and without xylanase supplementation
PubMed ID: 25595480
Broiler trial: xylanase increased apparent metabolizable energy (+1.4%) and improved dry‑matter and fat digestibility, implying better nutrient extraction/absorption in animals.
- Assessment of enzyme supplementation on growth performance and apparent nutrient digestibility in diets containing undecorticated sunflower seed meal in layer chicks
PubMed ID: 26047672
Exogenous enzymes in chicks improved digestibility of dry matter and crude protein — implies better nutrient absorption.
- Effect of zinc bacitracin and phytase on growth performance, nutrient digestibility, carcass and meat traits of broilers
PubMed ID: 26608478
Broiler phytase (bacterial) improved feed conversion and some ether‑extract (fat) digestibility metrics—supports better nutrient extraction in animals.
- Phosphorus digestibility response of growing pigs to phytase supplementation of triticale distillers' dried grains with solubles
PubMed ID: 26020749
Phytase added to pig diets increased apparent/total‑tract phosphorus digestibility—supports enzyme‑mediated nutrient uptake in animals.
- Comparison of two pancreatic enzyme products for exocrine insufficiency in patients with cystic fibrosis
PubMed ID: 27013382
Zenpep trial measured coefficient of fat absorption (CFA) and showed effective fat absorption—direct human evidence for improved nutrient (fat) absorption with enzyme therapy.
- Recombinant Bile Salt-Stimulated Lipase in Preterm Infant Feeding: A Randomized Phase 3 Study
PubMed ID: 27244221
rhBSSL aims to improve fat digestion/absorption in preterm infants; subgroup (SGA) showed improved growth and feeding utilization.
- Pancreatic Enzyme Replacement Therapy in Children with Severe Acute Malnutrition: A Randomized Controlled Trial
PubMed ID: 28912050
Pancreatic enzyme replacement addresses exocrine pancreatic insufficiency and is intended to improve macronutrient absorption; clinical benefits (lower mortality/faster discharge) support functional absorption gains.
- Standardized total tract digestibility of phosphorus in flaxseed meal fed to growing and finishing pigs without or with phytase supplementation
PubMed ID: 28380580
Microbial phytase in pigs increased phosphorus digestibility by ~14–15 percentage points—clear demonstration that exogenous enzymes improve mineral/nutrient digestibility (animal model).
- Exogenous protease supplementation of poultry by-product meal-based diets for broilers: Effects on growth, carcass characteristics and nutrient digestibility
PubMed ID: 28455873
Protease supplementation increased apparent metabolizable energy and nitrogen retention in broilers—strong evidence for improved absorption/digestibility.
- Effects of Pancreatic Enzyme Replacement Therapy on Body Weight and Nutritional Assessments After Pancreatoduodenectomy in a Randomized Trial
PubMed ID: 31520730
Post‑pancreatectomy PERT increased body weight and prealbumin (per‑protocol), strong signal of improved absorption.
- Preventive Effect of High-Dose Digestive Enzyme Management on Development of Nonalcoholic Fatty Liver Disease after Pancreaticoduodenectomy: A Randomized Controlled Clinical Trial
PubMed ID: 32927075
High‑dose PERT after PD markedly reduced NAFLD and improved protein/pre‑albumin — strong evidence of improved nutrient absorption.
- Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients With Celiac Disease Exposed to a Gluten Challenge
PubMed ID: 35931103
By protecting mucosal structure (Vh:Cd, IEL), latiglutenase likely preserves absorptive surface during gluten exposure.
- Functional Variation in Human CAZyme Genes in Relation to the Efficacy of a Carbohydrate-Restricted Diet in IBS Patients
PubMed ID: 39413891
hCAZyme variation implies altered carbohydrate processing which can influence nutrient handling and diet response.
- Low plasma pancreatic lipase as a novel predictor of nutritional target achievement and response to nutritional interventions in malnourished inpatients: Secondary analysis of a randomized clinical trial
PubMed ID: 40037114
Large inpatient cohort: low plasma pancreatic lipase linked to failure to meet nutrition targets—supports importance of exocrine function for nutrient uptake.
- Enteral nutrition and pancreatic enzymes: a synergistic approach to enhance patient outcomes? A randomized controlled trial
PubMed ID: 41307649
RCT in critically ill: pancreatic enzyme supplementation with enteral feeds slowed loss of muscle area, consistent with improved macronutrient utilization/absorption.
- Pancreatic Enzyme Replacement Therapy Improves Exclusive Enteral Nutrition Related Diarrhea in Crohn's Disease: A Prospective Randomized Trial
PubMed ID: 40243170
PERT in Crohn’s normalized stools and improved remission, implying improved nutrient handling/absorption.
Stomach comfort (56)
- [Benefits of a thickened infant formula with lactase activity in the management of benign digestive disorders in newborns]
PubMed ID: 15596352
Infant trial reported reduced digestive discomfort with lactase-supplemented formula, reflecting less stomach/abdominal discomfort.
- Daily low-dose versus alternate day full-dose lansoprazole in the maintenance treatment of reflux esophagitis
PubMed ID: 12094850
Lansoprazole maintenance dosing trial showed prevention of heartburn recurrence — relevant to symptom control (indirect to enzymes).
- Assessment of effectiveness of different dosage regimens of pantoprazole in controlling symptoms and healing esophageal lesions of patients with mild erosive esophagitis
PubMed ID: 12612717
Pantoprazole RCT directly showed relief of heartburn in erosive esophagitis — strong evidence for heartburn reduction (though not enzyme therapy).
- [Dose-dependent effect of pancreatin replacement upon the pancreatic function in the period after pancreatic surgery]
PubMed ID: 11816130
Disappearance of maldigestion symptoms with pancreatin indicates clear reduction in indigestion symptoms in postoperative patients.
- Comparison of pantoprazole 20 mg to ranitidine 150 mg b.i.d. in the treatment of mild gastroesophageal reflux disease
PubMed ID: 11351143
Large randomized trial showing pantoprazole relieved heartburn significantly more than ranitidine—strong evidence for heartburn symptom relief (antisecretory therapy).
- Esomeprazole once daily for 6 months is effective therapy for maintaining healed erosive esophagitis and for controlling gastroesophageal reflux disease symptoms: a randomized, double-blind, placebo-controlled study of efficacy and safety
PubMed ID: 11197282
Direct RCT showing esomeprazole effectively maintains healing and controls heartburn versus placebo.
- Effects on 24-hour intragastric pH: a comparison of lansoprazole administered nasogastrically in apple juice and pantoprazole administered intravenously
PubMed ID: 11467632
Nasogastric lansoprazole raised/sustained intragastric pH more than pantoprazole—relevant for heartburn relief.
- [Effect of pancreatin replacement on pancreatic function in the postoperative period after pancreatic surgery]
PubMed ID: 10628192
Maldigestion symptoms resolved in pancreatin group—direct clinical evidence of reduced indigestion after enzyme therapy.
- Early feeding, feeding tolerance, and lactase activity in preterm infants
PubMed ID: 9821422
Increased lactase reduced feeding intolerance in preterms → fewer lactose‑driven dyspeptic symptoms.
- Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy--Italian Group
PubMed ID: 8786777
Gabexate reduced abdominal pain rates after ERCP—evidence of reduced postprocedural stomach/abdominal discomfort.
- Long-term prophylactic administration of octreotide reduces the rise in serum amylase after endoscopic procedures on Vater's papilla
PubMed ID: 8783335
Octreotide prophylaxis reduced post‑ERCP epigastric pain from 43%→7%.
- Thermophilic amylase-digested rice-electrolyte solution in the treatment of acute diarrhea in children
PubMed ID: 7530834
Amylase ORS reduced diarrheal duration and improved feeding outcomes — likely reduces GI discomfort in children.
- Effects of pancreatic digestive enzymes, sodium bicarbonate, and a proton pump inhibitor on steatorrhoea caused by pancreatic diseases
PubMed ID: 7774757
Pancreatic enzyme replacement improves fat digestion and often relieves symptoms of dyspepsia related to malabsorption.
- Improving lactose digestion and symptoms of lactose intolerance with a novel galacto-oligosaccharide (RP-G28): a randomized, double-blind clinical trial
PubMed ID: 24330605
Significant reductions in abdominal pain with RP‑G28 indicate less stomach/gut discomfort in lactose‑intolerant individuals.
- Effect of Dewaxed Coffee on Gastroesophageal Symptoms in Patients with GERD: A Randomized Pilot Study
PubMed ID: 35745239
Dewaxed coffee produced more heartburn/regurgitation‑free days and improved related symptom scores in GERD patients.
- Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome
PubMed ID: 28724171
Patients reported reductions in abdominal pain and improved well‑being with the multi‑ingredient product including digestive enzymes.
- Effect of beta-glucan, inositol and digestive enzymes in GI symptoms of patients with IBS
PubMed ID: 21796867
Abdominal pain was reduced in the study of a supplement that included digestive enzymes, indicating less stomach/abdominal discomfort.
- Is a proton pump inhibitor necessary for the treatment of lower-grade reflux esophagitis?
PubMed ID: 10452673
Omeprazole (PPI) produced much higher healing rates for reflux esophagitis compared with an H2 blocker — direct, strong evidence for reducing heartburn symptoms (though not an enzyme supplement).
- Dietary management of acute diarrhoea in children: effect of fermented and amylase-digested weaning foods on intestinal permeability
PubMed ID: 9138166
Children fed amylase‑digested/fermented porridge recovered barrier function faster, reducing discomfort.
- Fecal microbiota transplantation alleviates mild-moderate COVID-19 associated diarrhoea and depression symptoms: A prospective study of a randomized, double-blind clinical trial
PubMed ID: 39056206
FMT resolved diarrhoea and is likely to reduce associated abdominal/stomach discomfort rapidly.
- Safety and Efficacy of N-SORB(®), a Proprietary KD120 MEC Metabolically Activated Enzyme Formulation: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 30971174
Multienzyme trial reported subjective benefits likely including reduced indigestion symptoms.
- Fat-Modified Enteral Formula Improves Feeding Tolerance in Critically Ill Patients: A Multicenter, Single-Blind, Randomized Controlled Trial
PubMed ID: 26350918
Enteral formula reduced feeding intolerance and abdominal distension—practical reduction in symptoms akin to indigestion in ICU patients.
- The efficacy of rebamipide add-on therapy in arthritic patients with COX-2 selective inhibitor-related gastrointestinal events: a prospective, randomized, open-label blinded-endpoint pilot study by the GLORIA study group
PubMed ID: 23306427
Rebamipide prevented upper-GI events and intolerable GI symptoms with COX-2 inhibitors—direct symptom relief relevant to indigestion.
- Enteral nutrition is superior to total parenteral nutrition for pancreatic cancer patients who underwent pancreaticoduodenectomy
PubMed ID: 21669582
Enteral nutrition reduced delayed gastric emptying and postoperative digestive complications — relevant to reducing indigestion in surgical patients.
- Bifidobacterium longum with fructo-oligosaccharides in patients with non alcoholic steatohepatitis
PubMed ID: 21901256
Probiotic+FOS reduced gut inflammation/endotoxin and improved NASH indices — can be associated with less stomach discomfort.
- Augmented eradication rates of Helicobacter pylori by new combination therapy with lansoprazole, amoxicillin, and rebamipide
PubMed ID: 9512112
Rebamipide increased H. pylori eradication and lowered mucosal oxidative stress—changes that can reduce dyspepsia/indigestion symptoms.
- Improved energy intakes using amylase-digested weaning foods in Tanzanian children with acute diarrhea
PubMed ID: 8576819
Amylase‑treated porridge improved intake/tolerance in diarrheal children — suggests reduction in feeding intolerance/indigestion.
- Pancreatic Enzyme Replacement Therapy Improves Exclusive Enteral Nutrition Related Diarrhea in Crohn's Disease: A Prospective Randomized Trial
PubMed ID: 40243170
Symptom improvements (stool normalization, remission) imply reduced abdominal/stomach discomfort in Crohn’s patients.
- Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
PubMed ID: 38617446
AN‑PEP reduced the number of patients with high CSI scores — direct improvement in indigestion symptoms in celiac patients.
- Application of Recombinant Human Superoxide Dismutase in Radical Concurrent Chemoradiotherapy for Cervical Cancer to Prevent and Treat Radiation-induced Acute Rectal Injury: A Multicenter, Randomized, Open-label, Prospective Trial
PubMed ID: 38705489
rhSOD enemas decreased diarrhea severity/duration after radiotherapy, reducing GI discomfort.
- Efficacy of digestive enzyme supplementation in functional dyspepsia: A monocentric, randomized, double-blind, placebo-controlled, clinical trial
PubMed ID: 37976892
Direct RCT evidence: multi‑enzyme supplement improved functional dyspepsia symptoms and QoL, consistent with reduced indigestion.
- Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients With Celiac Disease Exposed to a Gluten Challenge
PubMed ID: 35931103
Oral enzyme reduced symptom worsening (including dyspeptic symptoms) in celiac patients during gluten challenge.
- Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome: A prospective, interventional, randomized, double-blind, placebo-controlled clinical study [CONSORT Compliant]
PubMed ID: 33545934
Probiotic reduced abdominal pain and improved symptoms in IBS—translates to less stomach/abdominal discomfort.
- Endoscopic intragastric injection of botulinum toxin A in obese patients on bariatric surgery waiting lists: A randomised double-blind study (IntraTox study)
PubMed ID: 33092901
Improved GIQLI after intragastric BTX suggests reduced stomach discomfort in treated patients.
- Preventive Effect of High-Dose Digestive Enzyme Management on Development of Nonalcoholic Fatty Liver Disease after Pancreaticoduodenectomy: A Randomized Controlled Clinical Trial
PubMed ID: 32927075
PERT after PD likely reduces indigestion by replacing deficient enzymes; trial showed clear clinical benefit on nutrition and NAFLD reduction.
- Supplementation of Caricol®-Gastro reduces chronic gastritis disease associated pain
PubMed ID: 29604620
Significant reduction in chronic gastritis pain with papaya‑containing supplement vs placebo.
- Efficacy of actinidin-containing kiwifruit extract Zyactinase on constipation: a randomised double-blinded placebo-controlled clinical trial
PubMed ID: 29737803
Significant reductions in abdominal pain/painful defecation reported — supports less stomach/abdominal discomfort.
- Evaluation of the Safety and Efficacy of a Multienzyme Complex in Patients with Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 30156436
Direct evidence: RCT showed marked reductions in dyspepsia (indigestion) symptom scores versus placebo.
- Combination of Gluten-Digesting Enzymes Improved Symptoms of Non-Celiac Gluten Sensitivity: A Randomized Single-blind, Placebo-controlled Crossover Study
PubMed ID: 30228265
Enzyme supplement reduced overall symptom severity during gluten challenge, consistent with reduced indigestion symptoms.
- Pancreatic Enzyme Replacement Therapy in Children with Severe Acute Malnutrition: A Randomized Controlled Trial
PubMed ID: 28912050
Pancreatic enzyme replacement in severely malnourished children supports digestion of macronutrients and was associated with improved clinical outcomes, consistent with reduced indigestion from exocrine insufficiency.
- Comparison of two pancreatic enzyme products for exocrine insufficiency in patients with cystic fibrosis
PubMed ID: 27013382
Pancreatic enzyme replacement directly treats exocrine pancreatic insufficiency symptoms (malabsorption/indigestion) and showed comparable fat absorption to another established product.
- Potent Gastric Acid Inhibition Over 24 Hours by 4-Times Daily Dosing of Esomeprazole 20 mg
PubMed ID: 25924819
More frequent esomeprazole dosing produced stronger acid suppression—relevant to heartburn control (pharmacologic intervention).
- Effect of probiotics on postoperative quality of gastric bypass surgeries: a prospective randomized trial
PubMed ID: 26499352
Digestive enzyme preparation gave modest symptomatic GI improvement post‑bypass (human), consistent with reduced indigestion in that clinical setting.
- Prophylactic somatostatin can reduce incidence of post-ERCP pancreatitis: multicenter randomized controlled trial
PubMed ID: 25590178
Somatostatin reduced post‑ERCP pancreatitis and hyperamylasemia — directly reduced a major cause of stomach/abdominal discomfort in procedural patients.
- A double-blind, randomized, placebo-controlled trial studying the effects of Saccharomyces boulardii on the gastrointestinal tolerability, safety, and pharmacokinetics of miglustat
PubMed ID: 26084276
S. boulardii reduced diarrhea and GI AE incidence in miglustat users — direct human evidence of reduced GI discomfort from drug‑induced disaccharidase deficiency.
- Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease
PubMed ID: 24583059
ALV003 significantly prevented gluten‑induced mucosal injury and inflammatory IEL increases — directly reduces gluten‑mediated indigestion in celiac patients.
- The effect of oral pancreatic enzyme supplementation on the course and outcome of acute pancreatitis: a randomized, double-blind parallel-group study
PubMed ID: 24618443
Pancreatic enzyme supplementation shortened recovery and trended to QoL improvements, consistent with less abdominal discomfort in post‑pancreatitis patients.
- [Efficacy of compound digestive enzyme tablet for dyspeptic symptoms: a randomized double-blind parallel controlled multicenter clinical trial in China]
PubMed ID: 25622633
Compound digestive‑enzyme formulations achieved ~80% overall efficacy in dyspepsia patients, directly relevant to reducing indigestion symptoms.
- [Lactase deficiency in patients with postinfectious irritable bowel syndrome and the role of intestinal microflora in its development]
PubMed ID: 23402179
Symptom improvement after restoration of lactase function implies reduced indigestion for lactose‑sensitive individuals.
- A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery
PubMed ID: 21418260
Creon decreased abdominal pain and improved stool characteristics—consistent with reduced indigestion.
- Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial
PubMed ID: 20502447
Pancrelipase reduced GI symptom scores including abdominal pain/indigestion.
- Effects of extrusion and supplementation of exogenous enzymes to diets containing Chinese storage brown rice on the carbohydrase activity in the digestive tract of piglets
PubMed ID: 20465715
Exogenous enzyme supplementation increased intestinal carbohydrase activities and digestibility—supports reduction in indigestion in piglets.
- Interactions between xylanase and glucanase in maize-soy-based diets for broilers
PubMed ID: 20461586
Strong broiler data: xylanase+glucanase improved ileal digestibility and feed efficiency—likely to reduce indigestion from NSPs.
- Growth performance and nutrient digestibility in pigs fed wheat distillers dried grains with solubles-based diets supplemented with a multicarbohydrase enzyme
PubMed ID: 19359515
Improved digestibility in pigs reduces maldigestion-related indigestion—animal evidence.
- The efficacy of Combizym in the treatment of Chinese patients with dyspepsia: a multicenter, randomized, placebo-controlled and cross-over study: Shanghai Combizym Clinical Cooperative Group
PubMed ID: 19236546
Combizym RCT showed marked and rapid reduction in dyspepsia (indigestion) vs placebo — direct evidence.
- Impaired gastric myoelectricity in patients with chronic pancreatitis: role of maldigestion
PubMed ID: 15637747
Normalization of gastric myoelectricity with enzymes suggests reduced functional dyspepsia-like physiology.
Energy & Fatigue (33)
- Apparent and standardized total tract digestibility by growing pigs of phosphorus in canola meal from North America and 00-rapeseed meal and 00-rapeseed expellers from Europe without and with microbial phytase
PubMed ID: 26440018
Phytase increased availability of phosphorus (and indirectly other nutrients) which can increase usable nutrient extraction/energy in animals.
- Escherichia coli phytase improves growth performance of starter, grower, and finisher pigs fed phosphorus-deficient diets
PubMed ID: 16024708
Improved growth and feed efficiency in pigs with phytase implies more usable energy/nutrients from the same feed.
- The effect of microbial phytase and myo-inositol on performance and blood biochemistry of broiler chickens fed wheat/corn-based diets
PubMed ID: 23873561
Phytase/myo-inositol increased body weight gain and feed conversion in broilers, suggesting increased energy extraction from feed.
- Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis: A Randomized Placebo-Controlled Trial
PubMed ID: 26465792
Better fat absorption and increased plasma/muscle choline in CF children likely translate to improved energy/nutrient status.
- Effect of direct-fed fibrolytic enzymes on the lactational performance of dairy cows
PubMed ID: 10194681
Improved feed digestibility and increased milk production suggest increased extraction of energy from feed.
- Effect of an organized lipid matrix on lipid absorption and clinical outcomes in patients with cystic fibrosis
PubMed ID: 12183711
Marked increase in fat absorption (major dietary energy source) in CF suggests greater caloric extraction from meals.
- Influence of enzyme supplementation of maize-soyabean meal diets on carcase composition, whole-body nutrient accretion and total tract nutrient retention of broilers
PubMed ID: 18704790
Exogenous enzymes increased body nutrient accretion and nitrogen retention in broilers, consistent with better energy/nutrient extraction (animal).
- Effect of exogenous enzymes in maize-based diets varying in nutrient density for young broilers: growth performance and digestibility of energy, minerals and amino acids
PubMed ID: 18210288
Apparent metabolisable energy (AME) increased by ~3% with the enzyme cocktail in broilers — direct increase in extractable energy (animal).
- Performance and apparent total tract phosphorus and calcium digestibility in grower-finisher pigs fed diets with and without phytase
PubMed ID: 23365310
Phytase restored growth/performance on low‑P diets, reflecting improved usable energy/nutrient availability (animal).
- Nitrogen retention, energy, and amino acid digestibility of wheat bran, without or with multicarbohydrase and phytase supplementation, fed to broiler chickens
PubMed ID: 29746701
Multi‑enzyme+phytase increased apparent metabolizable energy in broilers — supports increased extractable energy when exogenous enzymes added (animal data).
- Effects of pancreatic digestive enzymes, sodium bicarbonate, and a proton pump inhibitor on steatorrhoea caused by pancreatic diseases
PubMed ID: 7774757
Improved fat absorption with pancreatic enzymes increases caloric uptake in steatorrhoea patients.
- Improved energy intakes using amylase-digested weaning foods in Tanzanian children with acute diarrhea
PubMed ID: 8576819
Amylase‑treated porridge raised mean daily energy intake by ~42% — clear increase in energy from food.
- Thermophilic amylase-digested rice-electrolyte solution in the treatment of acute diarrhea in children
PubMed ID: 7530834
Thermophilic amylase ORS reduced diarrhea and was associated with greater weight gain — indicates increased effective energy uptake.
- Enteral versus parenteral nutrition: effects on gastrointestinal function and metabolism
PubMed ID: 8838831
Enteral feeding increased visceral protein synthesis and improved nutritional indices, implying better energy utilization.
- Effects of beta-glucanase-producing Lactobacillus strains on growth, dry matter and crude protein digestibilities and apparent metabolisable energy in broiler chickens
PubMed ID: 16050187
Higher apparent metabolisable energy and improved growth in chickens indicate more usable energy extracted from feed when degradative enzymes are present (strong animal evidence).
- Enzyme complex containing carbohydrases and phytase improves growth performance and bone mineralization of broilers fed reduced nutrient corn-soybean-based diets
PubMed ID: 19687277
Broiler carbohydrase+phytase improved weight gain and feed efficiency — implies more extractable energy from feed (animal data).
- Growth performance and nutrient digestibility in pigs fed wheat distillers dried grains with solubles-based diets supplemented with a multicarbohydrase enzyme
PubMed ID: 19359515
Improved digestibility and growth in pigs implies more usable energy extracted from feed.
- Interactions between xylanase and glucanase in maize-soy-based diets for broilers
PubMed ID: 20461586
Xylanase+glucanase improved feed conversion ratio and ileal digestibility—strong animal evidence for more energy extracted from feed.
- Effects of extrusion and supplementation of exogenous enzymes to diets containing Chinese storage brown rice on the carbohydrase activity in the digestive tract of piglets
PubMed ID: 20465715
Exogenous enzymes increased carbohydrate enzyme activities and digestibility leading to better growth (proxy for increased energy extraction).
- Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial
PubMed ID: 20502447
Pancrelipase increased fat/protein absorption — likely improves usable energy in EPI patients.
- Multi-carbohydrase and phytase supplementation improves growth performance and liver insulin receptor sensitivity in broiler chickens fed diets containing full-fat rapeseed
PubMed ID: 20709979
Feed efficiency improved in broilers — more energy harvested from feed (animal data).
- Phosphorus utilization in starter pigs fed high-moisture corn-based liquid diets steeped with phytase
PubMed ID: 20729280
Phytase increased nutrient digestibility/retention and P/Ca retention — more extractable energy (animal data).
- The effect on performance, energy metabolism and hepatic carotenoid content when phytase supplemented diets were fed to broiler chickens
PubMed ID: 20362312
High phytase increased growth rates — more energy utilized from feed (animal evidence).
- Effects of exogenous enzymes in corn-based and Canadian pearl millet-based diets with reduced soybean meal on growth performance, intestinal nutrient digestibility, villus development, and selected microbial populations in broiler chickens
PubMed ID: 21821810
Improved AA and CP digestibility in broilers implies greater metabolic energy extraction from feed when enzymes are added (animal evidence).
- A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery
PubMed ID: 21418260
Mean body weight increased +2.7 kg on Creon over 6 months, indicating improved caloric/nutrient uptake and energy availability.
- Efficacy and safety of PANCREAZE® for treatment of exocrine pancreatic insufficiency due to cystic fibrosis
PubMed ID: 21632288
Preserved fat absorption prevents calorie loss in stools, supporting greater usable energy from food.
- Effects of dietary supplementation of multi-enzyme on growth performance, nutrient digestibility, small intestinal digestive enzyme activities, and large intestinal selected microbiota in weanling pigs
PubMed ID: 24663197
Improved apparent metabolizable energy and growth (ADG/G:F) in piglets implies more usable energy from the same food.
- Continual feeding of two types of microalgal biomass affected protein digestion and metabolism in laying hens
PubMed ID: 25568377
Protease improved amino acid digestibility in hens — more complete protein digestion can translate to more usable energy/nutrient availability in that model.
- Energy utilization and growth performance of chickens fed novel wheat inbred lines selected for different pentosan levels with and without xylanase supplementation
PubMed ID: 25595480
Xylanase supplementation in broilers increased apparent metabolizable energy (AMEn) by ≈1.4% and improved digestibility, indicating increased usable energy from feed (animal data).
- Assessment of enzyme supplementation on growth performance and apparent nutrient digestibility in diets containing undecorticated sunflower seed meal in layer chicks
PubMed ID: 26047672
Exogenous enzymes raised weight gain and digestibility in chicks — suggests greater energy availability from diet in animals.
- Effects of Pancreatic Enzyme Replacement Therapy on Body Weight and Nutritional Assessments After Pancreatoduodenectomy in a Randomized Trial
PubMed ID: 31520730
Weight gain and increased prealbumin with PERT imply better caloric/nutrient utilization and potential for more energy from food.
- Preventive Effect of High-Dose Digestive Enzyme Management on Development of Nonalcoholic Fatty Liver Disease after Pancreaticoduodenectomy: A Randomized Controlled Clinical Trial
PubMed ID: 32927075
Improved total protein/pre‑albumin and prevention of NAFLD imply better utilization of nutrients and likely increased usable energy from food after PERT.
- Enteral nutrition and pancreatic enzymes: a synergistic approach to enhance patient outcomes? A randomized controlled trial
PubMed ID: 41307649
Pancreatic enzyme supplementation with enteral nutrition slowed muscle loss—consistent with improved effective energy/nutrient availability.
Weight management (36)
- Transglucosidase improves the gut microbiota profile of type 2 diabetes mellitus patients: a randomized double-blind, placebo-controlled study
PubMed ID: 23657005
Oral transglucosidase shifted gut microbiota and associated HbA1c/BMI improvements in subsets of T2D patients — supports healthier metabolic outcomes.
- Efficacy and safety of PANCREAZE® for treatment of exocrine pancreatic insufficiency due to cystic fibrosis
PubMed ID: 21632288
Maintaining fat/protein absorption supports adequate nutrition and healthier eating in pancreatic insufficiency.
- A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery
PubMed ID: 21418260
By improving digestion/absorption and reducing GI symptoms, Creon enables better nutritional status and food tolerance.
- Orlistat 60 mg reduces visceral adipose tissue: a 24-week randomized, placebo-controlled, multicenter trial
PubMed ID: 21720429
Orlistat plus lifestyle produced greater weight/fat loss, showing that manipulating digestive processes can support healthier body composition and eating outcomes (inhibitor study).
- The effect on performance, energy metabolism and hepatic carotenoid content when phytase supplemented diets were fed to broiler chickens
PubMed ID: 20362312
High phytase improved growth and nutrient retention—supports improved feeding practices (animal evidence).
- Phosphorus utilization in starter pigs fed high-moisture corn-based liquid diets steeped with phytase
PubMed ID: 20729280
Phytase in pig diets improved digestibility and mineral retention, supporting better feed quality/utilization.
- Multi-carbohydrase and phytase supplementation improves growth performance and liver insulin receptor sensitivity in broiler chickens fed diets containing full-fat rapeseed
PubMed ID: 20709979
Enzyme supplementation improved feed efficiency and metabolic markers in broilers (supports better feeding outcomes in animals).
- Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial
PubMed ID: 20502447
By improving absorption and symptoms in EPI, pancrelipase can enable better nutrition and dietary tolerance.
- Effects of extrusion and supplementation of exogenous enzymes to diets containing Chinese storage brown rice on the carbohydrase activity in the digestive tract of piglets
PubMed ID: 20465715
Exogenous enzymes raised pancreatic/ileal carbohydrase activities and digestibility in piglets—supports the idea that enzymes can enable healthier ingestion/utilization of foods.
- Interactions between xylanase and glucanase in maize-soy-based diets for broilers
PubMed ID: 20461586
Xylanase+glucanase improved feed conversion and ileal digestibility in broilers—strong support that exogenous enzymes can enable healthier feeding outcomes.
- Growth performance and nutrient digestibility in pigs fed wheat distillers dried grains with solubles-based diets supplemented with a multicarbohydrase enzyme
PubMed ID: 19359515
Improved digestibility and growth in pigs suggests exogenous enzymes can support better utilization of diet, enabling healthier feed outcomes.
- The efficacy of Combizym in the treatment of Chinese patients with dyspepsia: a multicenter, randomized, placebo-controlled and cross-over study: Shanghai Combizym Clinical Cooperative Group
PubMed ID: 19236546
Combizym improved dyspepsia and meal comfort which may support more regular, healthier eating habits.
- A randomized controlled trial of a new behavioral home-based nutrition education program, "Eat Well with CF," in adults with cystic fibrosis
PubMed ID: 18442509
Home nutrition program for adults with CF improved nutrition knowledge/self‑efficacy and reported fat intake—supports better dietary management alongside enzyme therapy.
- Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial
PubMed ID: 18537181
Diet and exercise produced clear improvements in pediatric NAFLD and metabolic markers — directly supports healthier eating/lifestyle benefits.
- [Dose-dependent effect of pancreatin replacement upon the pancreatic function in the period after pancreatic surgery]
PubMed ID: 11816130
By restoring digestive function and preventing weight loss after pancreatic surgery, enzyme therapy supports the ability to tolerate and benefit from normal eating.
- [Effect of pancreatin replacement on pancreatic function in the postoperative period after pancreatic surgery]
PubMed ID: 10628192
By preventing weight loss and resolving maldigestion, pancreatin enabled better nutritional status and tolerance of food after surgery.
- Enteral versus parenteral nutrition: effects on gastrointestinal function and metabolism
PubMed ID: 8838831
Enteral feeding preserved GI function and improved nutritional indices, supporting better nutritional intake and status.
- Thermophilic amylase-digested rice-electrolyte solution in the treatment of acute diarrhea in children
PubMed ID: 7530834
Thermophilic amylase ORS enabled better feeding outcomes and weight gain in children, strongly supporting healthier feeding practices.
- Improved energy intakes using amylase-digested weaning foods in Tanzanian children with acute diarrhea
PubMed ID: 8576819
Amylase treatment increased energy intake markedly in young children with diarrhea, supporting improved nutritional intake/healthy eating.
- Effects of pancreatic digestive enzymes, sodium bicarbonate, and a proton pump inhibitor on steatorrhoea caused by pancreatic diseases
PubMed ID: 7774757
By correcting fat malabsorption, pancreatic enzymes support better nutritional status and healthier eating in affected patients.
- Dietary intervention induces flow of changes within biomarkers of lipids, inflammation, liver enzymes, and glycemic control
PubMed ID: 21820871
Two‑year dietary program produced sustained metabolic and liver benefits — strong support for healthier eating patterns.
- The supplementation of low-P diets with microbial 6-phytase expressed in Aspergillus oryzae increases P and Ca digestibility in growing pigs
PubMed ID: 23365288
Improved mineral availability with phytase reduces anti‑nutrient effects of phytate, supporting better dietary nutrient value.
- Combining functional features of whole-grain barley and legumes for dietary reduction of cardiometabolic risk: a randomised cross-over intervention in mature women
PubMed ID: 24063257
A diet rich in whole-grain barley and legumes improved cardiometabolic markers—supports dietary patterns consistent with healthier eating (dietary intervention, not enzymes).
- Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome
PubMed ID: 28724171
Improved GI symptoms and well‑being in IBD+IBS patients could support adherence to healthier eating patterns by reducing symptom‑related dietary restriction; evidence indirect.
- The Effect of Mobile Lifestyle Intervention Combined with High-Protein Meal Replacement on Liver Function in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: A Pilot Randomized Controlled Trial
PubMed ID: 39064697
Mobile coaching combined with structured high‑protein meal replacements directly targeted dietary behavior and improved body composition and liver enzymes — strong support for healthier eating.
- Effect of high-protein meal replacement on weight and cardiometabolic profile in overweight/obese Asian Indians in North India
PubMed ID: 28653586
High‑protein meal‑replacement RCT produced significant weight loss and metabolic improvements — strong support for healthier dietary patterns.
- The effects of dietary weight loss with or without exercise training on liver enzymes in obese metabolic syndrome subjects
PubMed ID: 21923735
Calorie restriction (with/without exercise) improved liver enzymes and insulin sensitivity, consistent with healthier eating benefits.
- Pancreatic Enzyme Replacement Therapy Improves Exclusive Enteral Nutrition Related Diarrhea in Crohn's Disease: A Prospective Randomized Trial
PubMed ID: 40243170
By correcting maldigestion and improving symptoms/remission, PERT enables better nutritional intake and supports healthier eating patterns in Crohn’s patients.
- Effects of an anti-lipogenic low-carbohydrate high polyunsaturated fat diet or a healthy Nordic diet versus usual care on liver fat and cardiometabolic disorders in type 2 diabetes or prediabetes: a randomized controlled trial (NAFLDiet)
PubMed ID: 41390743
One‑year randomized diet trial showed Healthy Nordic Diet and a targeted low‑carb/high‑PUFA diet reduced liver fat and improved metabolic markers — supports dietary patterns that constitute healthier eating (human RCT).
- Effects of Pancreatic Enzyme Replacement Therapy on Body Weight and Nutritional Assessments After Pancreatoduodenectomy in a Randomized Trial
PubMed ID: 31520730
Improved weight/prealbumin on PERT suggests better nutritional status, which can support healthier eating patterns post‑surgery.
- Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients With Celiac Disease Exposed to a Gluten Challenge
PubMed ID: 35931103
By reducing harm and symptoms from inadvertent gluten exposure, enzymes may help patients adhere to diets and sustain healthier eating patterns in that context.
- Effect of probiotics on postoperative quality of gastric bypass surgeries: a prospective randomized trial
PubMed ID: 26499352
Improved GI symptoms and quality of life after 2 weeks on a digestive enzyme preparation (post‑bypass) could support improved tolerance of oral intake and healthier eating patterns in that population.
- Continual feeding of two types of microalgal biomass affected protein digestion and metabolism in laying hens
PubMed ID: 25568377
Protease improved nutrient digestibility in poultry which enables better utilization of feed and healthier nutritional status in that model.
- Apparent and standardized total tract digestibility by growing pigs of phosphorus in canola meal from North America and 00-rapeseed meal and 00-rapeseed expellers from Europe without and with microbial phytase
PubMed ID: 26440018
Phytase improves nutrient availability in feeds, which can support more efficient use of diverse feedstuffs and thus healthier formulation in animal nutrition contexts.
- Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease
PubMed ID: 24583059
ALV003 allowed controlled gluten exposure without mucosal injury in celiac patients, potentially supporting safer dietary choices (e.g., accidental gluten exposure).
- Long-term inhibition of intestinal lipase by orlistat improves release of gut hormones increasing satiety in obese women
PubMed ID: 23950589
Orlistat increased satiety hormones and produced greater weight/fat loss over 8 weeks — supports dietary adherence/healthier eating patterns.
Bloating & gas (30)
- Fat-Modified Enteral Formula Improves Feeding Tolerance in Critically Ill Patients: A Multicenter, Single-Blind, Randomized Controlled Trial
PubMed ID: 26350918
Enteral formula reduced abdominal distension—direct evidence for reduced bloating/pressure in ICU feeding.
- Safety and Efficacy of N-SORB(®), a Proprietary KD120 MEC Metabolically Activated Enzyme Formulation: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 30971174
Subjects had modest symptomatic/QoL benefits consistent with less bloating though bloating wasn't specifically measured.
- Effect of beta-glucan, inositol and digestive enzymes in GI symptoms of patients with IBS
PubMed ID: 21796867
Bloating was a primary symptom improved in the trial of the multi‑ingredient product that included digestive enzymes.
- Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome
PubMed ID: 28724171
The IBD+IBS trial reported significant reductions in bloating with the supplement containing digestive enzymes.
- Wheat-barley-rye- or corn-fed growing pigs respond differently to dietary supplementation with a carbohydrase complex
PubMed ID: 22345107
Improved carbohydrate digestion with carbohydrase can reduce substrate for fermentation and resultant bloating.
- Effect of Dewaxed Coffee on Gastroesophageal Symptoms in Patients with GERD: A Randomized Pilot Study
PubMed ID: 35745239
Dewaxed coffee reduced reported abdominal bloating scores in GERD patients vs standard coffee.
- Improving lactose digestion and symptoms of lactose intolerance with a novel galacto-oligosaccharide (RP-G28): a randomized, double-blind clinical trial
PubMed ID: 24330605
RP‑G28 lowered lactose intolerance symptoms and tended to reduce breath hydrogen (marker of fermentation/gas) — supports reduced gas in lactose‑intolerant humans.
- Effects of pancreatic digestive enzymes, sodium bicarbonate, and a proton pump inhibitor on steatorrhoea caused by pancreatic diseases
PubMed ID: 7774757
Pancreatic enzymes reduce steatorrhoea and often alleviate bloating from fat malabsorption.
- Early feeding, feeding tolerance, and lactase activity in preterm infants
PubMed ID: 9821422
Raising lactase reduces lactose fermentation → directly reduces bloating in lactose-intolerant scenarios.
- Effects of beano on the tolerability and pharmacodynamics of acarbose
PubMed ID: 9663365
Crossover trial: Beano (alpha‑galactosidase) added to acarbose reduced flatulence scores and breath hydrogen markedly.
- [Effect of pancreatin replacement on pancreatic function in the postoperative period after pancreatic surgery]
PubMed ID: 10628192
Elimination of maldigestion symptoms after pancreatin implies improvements in bloating for postoperative patients.
- [Benefits of a thickened infant formula with lactase activity in the management of benign digestive disorders in newborns]
PubMed ID: 15596352
Trial showed significant decreases in gas frequency and intensity with a lactase-containing formula vs standard formula.
- The efficacy of Combizym in the treatment of Chinese patients with dyspepsia: a multicenter, randomized, placebo-controlled and cross-over study: Shanghai Combizym Clinical Cooperative Group
PubMed ID: 19236546
Combizym substantially reduced dyspepsia symptoms which commonly include bloating — direct clinical evidence.
- Interactions between xylanase and glucanase in maize-soy-based diets for broilers
PubMed ID: 20461586
Xylanase+glucanase improved digestibility in broilers and likely reduces undigested fermentable substrates causing bloating.
- Effects of extrusion and supplementation of exogenous enzymes to diets containing Chinese storage brown rice on the carbohydrase activity in the digestive tract of piglets
PubMed ID: 20465715
Exogenous carbohydrases increased carbohydrase activities and digestibility in piglets—supports reduction of bloating from undigested carbs.
- Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial
PubMed ID: 20502447
Pancrelipase reduced flatulence in EPI patients.
- A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery
PubMed ID: 21418260
Reported reductions in abdominal symptoms (including bloating/flatulence) with Creon therapy.
- [Lactase deficiency in patients with postinfectious irritable bowel syndrome and the role of intestinal microflora in its development]
PubMed ID: 23402179
Restored lactose metabolism and symptom recovery in postinfectious IBS patients reduces bloating associated with lactose malabsorption.
- Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children: a randomized, double-blind, placebo controlled trial
PubMed ID: 24063420
Direct RCT in children: oral α‑galactosidase significantly reduced flatulence and bloating days vs placebo.
- [The role of small bowel microflora in the development of secondary lactase deficiency and the possibilities of its treatment with probiotics]
PubMed ID: 23653934
Probiotic treatment reduced small‑bowel bacterial overgrowth and restored lactase in many patients — likely to lower gas from carbohydrate malabsorption.
- Prevalence of lactose intolerance in Chile: a double-blind placebo study
PubMed ID: 25096822
Lactase‑nonpersistence study documents breath-test positivity and symptoms; lactase enzyme replacement commonly reduces gas in lactose malabsorbers (indirect support).
- [Efficacy of compound digestive enzyme tablet for dyspeptic symptoms: a randomized double-blind parallel controlled multicenter clinical trial in China]
PubMed ID: 25622633
Dyspepsia symptom benefit likely includes bloating relief for many participants though bloating not separately quantified.
- Effect of probiotics on postoperative quality of gastric bypass surgeries: a prospective randomized trial
PubMed ID: 26499352
Human trial after gastric bypass: participants receiving digestive enzymes reported symptomatic improvement including bloating items, supporting reduced bloating short‑term.
- Combination of Gluten-Digesting Enzymes Improved Symptoms of Non-Celiac Gluten Sensitivity: A Randomized Single-blind, Placebo-controlled Crossover Study
PubMed ID: 30228265
Primary trial endpoint included bloating/incomplete evacuation; enzyme mix reduced symptom scores and trended to lower bloating.
- Evaluation of the Safety and Efficacy of a Multienzyme Complex in Patients with Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 30156436
Significant reduction in dyspepsia symptoms (which commonly include bloating) supports benefit for bloating.
- Efficacy of actinidin-containing kiwifruit extract Zyactinase on constipation: a randomised double-blinded placebo-controlled clinical trial
PubMed ID: 29737803
Kiwifruit improved stool form and abdominal pain; likely to reduce bloating in constipated individuals though not explicitly reported.
- Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome: A prospective, interventional, randomized, double-blind, placebo-controlled clinical study [CONSORT Compliant]
PubMed ID: 33545934
Probiotic improved abdominal pain and related discomforts including bloating in IBS patients.
- Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients With Celiac Disease Exposed to a Gluten Challenge
PubMed ID: 35931103
Symptom attenuation with latiglutenase likely reduces bloating during gluten exposure.
- Efficacy of digestive enzyme supplementation in functional dyspepsia: A monocentric, randomized, double-blind, placebo-controlled, clinical trial
PubMed ID: 37976892
RCT reported improved dyspepsia‑related QoL and pain reduction — plausible improvement in bloating as part of global dyspepsia symptom benefit.
- Functional Variation in Human CAZyme Genes in Relation to the Efficacy of a Carbohydrate-Restricted Diet in IBS Patients
PubMed ID: 39413891
hCAZyme gene effects influenced response to low‑FODMAP diet — FODMAP content is a major driver of fermentative gas, so enzyme‑related carbohydrate handling is highly relevant.
Appetite suppression (6)
- Effect of high-protein meal replacement on weight and cardiometabolic profile in overweight/obese Asian Indians in North India
PubMed ID: 28653586
High‑protein meal‑replacement RCT produced significant weight loss and likely improved satiety/appetite control.
- Effect of dulaglutide on liver fat in patients with type 2 diabetes and NAFLD: randomised controlled trial (D-LIFT trial)
PubMed ID: 32865597
Dulaglutide (GLP‑1 agonist) reduces appetite and produced meaningful metabolic effects — relevant for appetite control though not an enzyme supplement.
- Voglibose (AO-128) is an efficient alpha-glucosidase inhibitor and mobilizes the endogenous GLP-1 reserve
PubMed ID: 8536820
Voglibose markedly increased GLP‑1 (>80–90%), a key satiety hormone, so strong relevance to appetite control.
- Improved energy intakes using amylase-digested weaning foods in Tanzanian children with acute diarrhea
PubMed ID: 8576819
Amylase‑treated porridge increased daily energy intake by ~42% indicating improved intake/appetite in children.
- Thermophilic amylase-digested rice-electrolyte solution in the treatment of acute diarrhea in children
PubMed ID: 7530834
Amylase‑digested rice ORS increased intake/weight gain — suggests improved feeding/appetite in children with diarrhea.
- Long-term inhibition of intestinal lipase by orlistat improves release of gut hormones increasing satiety in obese women
PubMed ID: 23950589
Orlistat (lipase inhibitor) increased GLP‑1 and PYY ~2x and produced greater weight/fat loss — supports improved appetite control (mechanistic, human RCT).
Similar by evidence
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Products with Digestive Enzymes
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Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.