Phosphatidylserine
11 benefits mapped to clinical evidence across supplements.
Dose per serving from products
1,015 products in our catalogue print how much Phosphatidylserine a serving holds.
Most common: 50 mg to 100 mg, 41% of 1,015 products.
| Dose per serving | Products |
|---|---|
| 5 mg or less | 35 |
| 5 mg to 10 mg | 53 |
| 10 mg to 25 mg | 116 |
| 25 mg to 50 mg | 206 |
| 50 mg to 100 mg | 415 |
| 100 mg to 250 mg | 127 |
| 250 mg to 500 mg | 49 |
| over 500 mg | 14 |
Dose per serving from research
22 study groups in 17 studies say how much Phosphatidylserine participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 50% of 22 study groups.
| Daily dose | Study groups |
|---|---|
| 50 mg to 100 mg | 4 |
| 100 mg to 250 mg | 6 |
| 250 mg to 500 mg | 11 |
| over 500 mg | 1 |
Benefit Evidence
Research sources
Brain health (12)
- The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial
PubMed ID: 23495677
Randomized, placebo-controlled trial in children with ADHD showed clinically meaningful improvements in core symptoms and short-term memory with soy-derived PS.
- Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer's disease. A neuropsychological, EEG, and PET investigation
PubMed ID: 8038871
Randomized study in AD demonstrating early cognitive and EEG/metabolism changes with PS+training supports overall cognitive benefit, though effects waned.
- Activation PET as an instrument to determine therapeutic efficacy in Alzheimer's disease
PubMed ID: 8239307
Direct human trial in AD showing increased regional glucose metabolism and improved cognitive test performance early with PS+trainingâstrong evidence for cognitive support (short-term).
- Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration
PubMed ID: 8323999
Large RCT in elderly demonstrated cognitive and behavioral improvements with PS.
- Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type
PubMed ID: 1633433
Early dementia trial reported clinical global improvement and EEG normalization with PS.
- Effects of phosphatidylserine in Alzheimer's disease
PubMed ID: 1609044
Bovine cortex PS improved some cognitive tests in probable AD.
- Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer's disease and dementia
PubMed ID: 25414047
Review/compilation of RCTs and PK studies showing repeated cognitive and functional stabilization signals with soy PS+PA.
- Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial
PubMed ID: 20523044
Randomized PSâDHA trial showed significant immediate verbal recall benefit in nonâdemented elderly.
- Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study
PubMed ID: 24577097
Openâlabel PSâDHA in elderly demonstrated improvement/maintenance of cognitive measures across 15 weeks.
- Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: effect of dietary n-3 fatty acids containing phospholipids
PubMed ID: 18469236
Phospholipidâbound nâ3 intervention (including PS carrier) improved biochemical incorporation and sustained attention in children with attention problems, supporting cognitive outcomes.
- A Magtein(ÂŽ), Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
PubMed ID: 36558392
Doubleâblind randomized trial of a MgâLâthreonate + PS formula showed broad, significant cognitive and memory improvements in healthy adults.
- Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
PubMed ID: 39317299
Large 12âmonth RCT in MCI using a PSâcontaining multiânutrient supplement improved multiple cognitive measures versus placebo.
Memory (10)
- The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial
PubMed ID: 23495677
Soy-derived PS (200 mg/day) for 2 months improved short-term auditory memory in children with ADHD vs placeboâdirect memory benefit.
- Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
PubMed ID: 39317299
12âmonth RCT in MCI with a PSâcontaining multiânutrient supplement improved shortâterm memory and other cognitive measures versus placebo.
- A Magtein(ÂŽ), Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
PubMed ID: 36558392
Randomized doubleâblind trial of a PSâcontaining MagteinÂŽ formula produced significant gains on multiple memory tests and overall memory quotient.
- Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study
PubMed ID: 24577097
Openâlabel PSâDHA improved sustained attention and memory recognition in previously untreated elderly with memory complaints.
- Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial
PubMed ID: 20523044
PSâDHA randomized trial improved immediate verbal recall in nonâdemented elderly (direct PS formulation evidence).
- Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer's disease and dementia
PubMed ID: 25414047
Compilation of trials showed repeated signals of improved/stabilized memory and ADLs with soy PS+PA formulations.
- Effects of phosphatidylserine in Alzheimer's disease
PubMed ID: 1609044
Bovine cortex PS improved some cognitive scores in probable AD, especially milder cases.
- Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration
PubMed ID: 8323999
Large multicenter RCT in elderly showed memory and behavioral improvements with 300 mg/day PS.
- Activation PET as an instrument to determine therapeutic efficacy in Alzheimer's disease
PubMed ID: 8239307
In AD patients PS+training increased cognitive test performance and regional brain glucose uptake early in treatmentâsupports memory improvements short-term.
- Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer's disease. A neuropsychological, EEG, and PET investigation
PubMed ID: 8038871
Randomized study showed early neuropsychological improvements with PS+training that waned by 6 monthsâsome memory benefit early on.
Healthy aging (10)
- Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration
PubMed ID: 8323999
Large multicenter RCT in elderly showed cognitive and behavioral improvements with 300 mg/day PS over 6 months.
- Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
PubMed ID: 39317299
12âmonth RCT in MCI patients using a PSâcontaining multiânutrient supplement produced clinically meaningful cognitive improvements and biochemical changes relevant to brain health.
- A Magtein(ÂŽ), Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
PubMed ID: 36558392
MagteinÂŽ formula with PS improved cognitive performance in healthy adults, with larger gains in older participants â consistent with support for brain aging.
- Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study
PubMed ID: 24577097
Openâlabel PSâDHA study in elderly with memory complaints showed maintenance/improvements in attention/recognition over 15 weeks.
- Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial
PubMed ID: 20523044
PSâDHA improved immediate recall in nonâdemented elderlyâdirect evidence relevant to brain aging.
- Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer's disease and dementia
PubMed ID: 25414047
Compilation of human studies documented absorption and repeated signals of memory/ADL/mood stabilization with soy PS+PA in elderly and AD.
- Effects of phosphatidylserine in Alzheimer's disease
PubMed ID: 1609044
Bovine cortex PS improved cognitive tests in probable AD, larger benefit in less severe cases.
- Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type
PubMed ID: 1633433
300 mg/day PS produced clinical global improvements and EEG normalization in early dementia.
- Activation PET as an instrument to determine therapeutic efficacy in Alzheimer's disease
PubMed ID: 8239307
In AD patients PS+training increased task-related cerebral glucose uptake and improved cognitive scores earlyâsupports short-term symptomatic benefit in aging brain.
- Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer's disease. A neuropsychological, EEG, and PET investigation
PubMed ID: 8038871
Randomized AD trial showed early cognitive/EEG/glucose metabolism improvements with PS+training, though effects faded over 6 months.
Focus & concentration (6)
- The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial
PubMed ID: 23495677
PS improved core ADHD symptoms (inattention/impulsivity) and auditory working memoryâstrong evidence for improved focus in this pediatric sample.
- Activation PET as an instrument to determine therapeutic efficacy in Alzheimer's disease
PubMed ID: 8239307
Neuropsychological performance improvements in PS+training AD trial include attention-related measures early in treatment.
- Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study
PubMed ID: 24577097
Openâlabel PSâDHA study reported improvements in sustained attention in elderly with memory complaints.
- Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: effect of dietary n-3 fatty acids containing phospholipids
PubMed ID: 18469236
Randomized trial using EPA/DHA esterified to phospholipids (including PS carrier) produced greater improvement in sustained visual attention (TOVA) than fish oil or placebo.
- A Magtein(ÂŽ), Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
PubMed ID: 36558392
Broad cognitive improvements in the RCT of a PSâcontaining product included attentionârelated test gains consistent with improved focus.
- Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
PubMed ID: 39317299
MCI study with PSâcontaining supplement improved several cognitive domains including attentionârelated measures.
Mood balance (4)
- Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer's disease and dementia
PubMed ID: 25414047
Compilation reported mood improvements/stabilization in elderly and AD patients with soy PS+PA.
- Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration
PubMed ID: 8323999
Behavioral improvements in the large elderly trial indicate mood/behavior stabilization.
- A lecithin phosphatidylserine and phosphatidic acid complex (PAS) reduces symptoms of the premenstrual syndrome (PMS): Results of a randomized, placebo-controlled, double-blind clinical trial
PubMed ID: 29576358
PAS (PS+PA) reduced PMS symptom scores including mood symptoms over three cyclesâdirect mood stabilization evidence.
- Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress
PubMed ID: 15512856
PS+PA reduced subjective distress during acute stress, indicating mood stabilization under stress.
Learning (4)
- The cognitive effects of supplementation with sunflower phosphatidyl serine in healthy children aged 8 to 12 years: a randomized controlled trial
PubMed ID: 41318468
Sunflower PS improved visuospatial learning in underperforming children (subgroup effect).
- Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial
PubMed ID: 20523044
PSâDHA improved immediate recall and learning measures in nonâdemented elderly (esp. higher baseline cognition).
- A Magtein(ÂŽ), Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
PubMed ID: 36558392
Multiâdomain cognitive gains in a randomized trial using a PSâcontaining formula indicate improved learning/learningârelated memory performance.
- Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
PubMed ID: 39317299
MCI RCT with PSâcontaining supplement improved several cognitive subtests that relate to learning capacity.
Stress resilience (4)
- Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial
PubMed ID: 30796508
Curcuminâphosphatidylserine phytosome lowered serum cortisol versus placebo in an 8âweek RCT, indicating reduced HPA axis activation.
- Untitled
PubMed ID: 22575036
Highâchronicâstress subgroup experienced restored cortisol responses and stress reduction with omegaâ3 PS.
- Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress
PubMed ID: 15512856
400 mg PS+PA clearly blunted ACTH and cortisol responses to the Trier Social Stress Test and reduced subjective distress.
- A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study
PubMed ID: 25081826
PAS400 reduced ACTH and cortisol responses in chronically stressed menârobust endocrine evidence in subgroup.
Stress & Anxiety (4)
- Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial
PubMed ID: 30796508
CurcuminâPS phytosome lowered serum cortisol in an RCT, which commonly correlates with reductions in perceived stress.
- A lecithin phosphatidylserine and phosphatidic acid complex (PAS) reduces symptoms of the premenstrual syndrome (PMS): Results of a randomized, placebo-controlled, double-blind clinical trial
PubMed ID: 29576358
PMS symptoms (including emotional/stress aspects) were reduced with PAS.
- A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study
PubMed ID: 25081826
Chronically stressed men on PAS400 showed reduced perceived chronic stress and lower cortisol responses.
- Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress
PubMed ID: 15512856
Subjects on 400 mg PS+PA reported decreased subjective distress during an acute psychosocial stressor.
Mental clarity (3)
- Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
PubMed ID: 39317299
12âmonth RCT in MCI with a multiânutrient product containing PS improved several cognitive test scores (arithmetic, similarity, shortâterm memory).
- Activation PET as an instrument to determine therapeutic efficacy in Alzheimer's disease
PubMed ID: 8239307
Short-term cognitive test improvements in AD patients receiving PS+training suggest clearer cognitive function early in treatment.
- A Magtein(ÂŽ), Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
PubMed ID: 36558392
30âday randomized trial of MagteinÂŽ formula (contains PS) produced robust improvements across multiple cognitive/memory tests consistent with enhanced clarity.
Workout performance (2)
- New Nutraceutical Combination Reduces Blood Pressure and Improves Exercise Capacity in Hypertensive Patients Via a Nitric Oxide-Dependent Mechanism
PubMed ID: 32078787
Multiâingredient nutraceutical that included PS improved VO2 and exercise tolerance in hypertensive patients.
- Interval aerobic/resistance exercise training depresses adrenergic-induced apoptosis of lymphocytes in sedentary males
PubMed ID: 37712975
Six weeks of interval training (physiology study) improved aerobic capacity and muscle endurance; not a PS supplement trial but shows context where PS biology was measured.
Energy & Fatigue (1)
- A Magtein(ÂŽ), Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
PubMed ID: 36558392
Cognitive improvements in the 30âday RCT may reflect reduced cognitive fatigue, though direct fatigue measures were not the primary endpoint.
Similar by evidence
Supplements the same benefits carry qualifying findings for â a fact about the evidence graph, not a recommendation to swap.
Products with Phosphatidylserine
Search all1741 products whose verified label declares Phosphatidylserine â not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet â this is what the field is asking, not what it found.