Flaxseed Oil
17 benefits mapped to clinical evidence across supplements.
Dose per serving from products
583 products in our catalogue print how much Flaxseed Oil a serving holds.
Most common: 500 mg to 1 g, 50% of 583 products.
| Dose per serving | Products |
|---|---|
| 50 mg or less | 29 |
| 50 mg to 100 mg | 24 |
| 100 mg to 250 mg | 27 |
| 250 mg to 500 mg | 72 |
| 500 mg to 1 g | 291 |
| 1 g to 2.5 g | 114 |
| over 2.5 g | 26 |
Dose per serving from research
36 study groups in 32 studies say how much Flaxseed Oil participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 g to 2.5 g, 36% of 36 study groups.
| Daily dose | Study groups |
|---|---|
| 500 mg to 1 g | 3 |
| 1 g to 2.5 g | 13 |
| 2.5 g to 5 g | 5 |
| 5 g to 10 g | 9 |
| 10 g to 25 g | 4 |
| over 25 g | 2 |
Commonly used together
14 of 49 study groups took Flaxseed Oil with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Alpha-Linolenic Acid | 6 |
Benefit Evidence
Research sources
Inflammation (19)
- Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients
PubMed ID: 12818406
Randomized trial in dyslipidaemic men: ALA significantly lowered CRP (−38%), SAA and IL‑6 — strong anti‑inflammatory biomarker evidence.
- Cheek cell fatty acids reflect n-3 PUFA in blood fractions during linseed oil supplementation: a controlled human intervention study
PubMed ID: 24229084
Improved n-6:n-3 ratio and increased ALA/EPA in tissues, which can favorably shift inflammatory balance.
- The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression of lipoprotein(a) and oxidized low-density lipoprotein, lipid profiles and biomarkers of oxidative stress in patients with polycystic ovary syndrome
PubMed ID: 27619403
Downregulated Ox-LDL and Lp(a) mRNAs and improved lipid markers in PCOS women (anti-inflammatory/lipid effects).
- Flaxseed Oil Supplementation Improve Gene Expression Levels of PPAR-γ, LP(a), IL-1 and TNF-α in Type 2 Diabetic Patients with Coronary Heart Disease
PubMed ID: 28916975
Clear downregulation of inflammatory cytokine mRNAs (IL-1, TNF-α) and upregulation of PPAR-γ in PBMCs.
- Effect of α-linolenic acid on vascular function and metabolic risk markers during the fasting and postprandial phase: A randomized placebo-controlled trial in untreated (pre-)hypertensive individuals
PubMed ID: 31818531
Modest reductions in TNF-α and fasting FFA after high-dose ALA, indicating some anti-inflammatory signal.
- Increased EPA levels in serum phospholipids of humans after four weeks daily ingestion of one portion chicken fed linseed and rapeseed oil
PubMed ID: 22913248
Human trial (linseed via chicken) increased ALA/EPA and lowered AA/EPA ratio—favourable for inflammatory balance.
- Effects of olive oil and flaxseed consumption in a healthy diet on endothelial function, plasma lipids and inflammatory factors of patients with coronary heart disease: a randomized clinical trial
PubMed ID: 37335239
CHD RCT: flaxseed+olive oil significantly reduced IL‑6, TNF‑α and MCP‑1—strong human anti‑inflammatory signal.
- Plasma fatty acid changes following consumption of dietary oils containing n-3, n-6, and n-9 fatty acids at different proportions: preliminary findings of the Canola Oil Multicenter Intervention Trial (COMIT)
PubMed ID: 24754911
Feeding study: FlaxSaff markedly increased plasma ALA and total n‑3 PUFA—biomarker change consistent with anti‑inflammatory potential.
- Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial
PubMed ID: 28716357
In diabetic foot ulcer patients, flaxseed oil reduced ulcer size and improved hs‑CRP, insulin resistance and antioxidant markers—strong clinical anti‑inflammatory and healing effects.
- The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial
PubMed ID: 28342967
Parkinson's trial showed reductions in hs‑CRP and increased TAC alongside clinical benefit—supports inflammation modulation.
- The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression related to inflammation, insulin and lipid in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial
PubMed ID: 30554092
PBMC gene expression changes (TNF‑α down) indicate anti‑inflammatory effects at the immune‑cell level in humans.
- A comparison between the effects of flaxseed oil and fish oil supplementation on cardiovascular health in type 2 diabetic patients with coronary heart disease: A randomized, double-blinded, placebo-controlled trial
PubMed ID: 31190359
In T2D with coronary disease, flaxseed oil reduced hs‑CRP and increased TAC—clinically relevant anti‑inflammatory/antioxidant effects.
- [Oral flaxseed oil (Linum usitatissimum) in the treatment for dry-eye Sjögren's syndrome patients]
PubMed ID: 17906762
Oral flaxseed oil improved dry‑eye signs and ocular surface inflammation in Sjögren's patients.
- Flaxseed oil supplementation decreases C-reactive protein levels in chronic hemodialysis patients
PubMed ID: 23244537
Large randomized trial in hemodialysis patients showed significant and sustained CRP reductions with flaxseed oil.
- Effects of Flaxseed Oil on Serum Lipids and Lipoproteins in Hemodialysis Patients: a Randomized Controlled Trial
PubMed ID: 27904000
8‑week flax oil lowered triglycerides and has been associated with reduced inflammatory markers in dialysis trials (inflammatory context).
- Effect of flaxseed oil on serum systemic and vascular inflammation markers and oxidative stress in hemodialysis patients: a randomized controlled trial
PubMed ID: 27115157
6 g/day flax oil reduced hs‑CRP and sVCAM‑1 in hemodialysis patients — robust anti‑inflammatory vascular signal.
- Unsaturated Fatty Acids Improve Atherosclerosis Markers in Obese and Overweight Non-diabetic Elderly Patients
PubMed ID: 28470492
CIMT reduction and trend to lower hs‑CRP suggest anti‑inflammatory/vascular benefit in overweight/obese elderly.
- Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis
PubMed ID: 31519285
Ground flaxseed and flax oil both markedly lowered fecal calprotectin, IL‑6, IFN‑γ and Mayo score in ulcerative colitis — strong anti‑inflammatory disease benefit.
- The effects of flaxseed supplementation on gene expression and inflammation in ulcerative colitis patients: An open-labelled randomised controlled trial
PubMed ID: 33482045
Strongest direct evidence: significant reductions in hs-CRP and disease activity in UC after flaxseed/oil over 12 weeks.
Heart health (19)
- Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial
PubMed ID: 26047766
Triglyceride reductions and plasma n-3 rises in NASH patients; ALA increases correlated with better histology (cardiometabolic relevance).
- The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression of lipoprotein(a) and oxidized low-density lipoprotein, lipid profiles and biomarkers of oxidative stress in patients with polycystic ovary syndrome
PubMed ID: 27619403
Improvements in triglycerides, LDL and downregulation of Lp(a)/Ox-LDL mRNA support heart-related effects.
- Consumption of echium oil increases EPA and DPA in blood fractions more efficiently compared to linseed oil in humans
PubMed ID: 26892399
Reliable increases in blood EPA/DPA (though no DHA) are relevant to cardiovascular biomarkers.
- Long-term vitamin D and high-dose n-3 fatty acids' supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD
PubMed ID: 31309919
Combined vitamin D + flaxseed for 6 months reduced carotid IMT and improved cardiometabolic markers—strong heart‑relevant outcome though co‑supplemented.
- Metabolic response to omega-3 fatty acid supplementation in patients with diabetic nephropathy: A randomized, double-blind, placebo-controlled trial
PubMed ID: 26611718
Flaxseed oil lowered triglycerides/VLDL and improved insulin measures in diabetic nephropathy—cardiometabolic benefit relevant to heart health.
- Plasma fatty acid changes following consumption of dietary oils containing n-3, n-6, and n-9 fatty acids at different proportions: preliminary findings of the Canola Oil Multicenter Intervention Trial (COMIT)
PubMed ID: 24754911
Full‑feeding trial: FlaxSaff raised plasma ALA and total n‑3 PUFA (biomarkers linked to cardiovascular benefit).
- Metabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndrome
PubMed ID: 21640360
PCOS RCT: flaxseed oil significantly lowered serum triglycerides—cardio‑metabolic benefit in humans.
- Effects of olive oil and flaxseed consumption in a healthy diet on endothelial function, plasma lipids and inflammatory factors of patients with coronary heart disease: a randomized clinical trial
PubMed ID: 37335239
Randomized CHD trial: flaxseed+olive oil improved endothelial function and lowered inflammatory markers and total cholesterol.
- Evaluation of Influencing Factors on Metabolism of Land-Based n-3 Poly Unsaturated Fatty Acids-The KoALA Study
PubMed ID: 37892536
Marked erythrocyte ALA/EPA increases (but DHA fall) that may affect cardiovascular risk profile.
- Flaxseed Oil Supplementation Improve Gene Expression Levels of PPAR-γ, LP(a), IL-1 and TNF-α in Type 2 Diabetic Patients with Coronary Heart Disease
PubMed ID: 28916975
Favorable PBMC lipid/inflammatory gene shifts in diabetic coronary patients imply cardioprotective signaling.
- Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension
PubMed ID: 1972963
2‑week linseed‑oil diet in mildly hypertensive men lowered total cholesterol, LDL and triglycerides (clinically relevant lipid improvements).
- Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients
PubMed ID: 17268413
Randomized trial: 12 weeks of flaxseed oil lowered both systolic and diastolic blood pressure versus n‑6 control (robust cardiovascular signal).
- Lignan content of the flaxseed influences its biological effects in healthy men and women
PubMed ID: 23885993
Flaxseed (high-lignan) lowered total/LDL and Ox-LDL — relevant to cardiovascular risk.
- Thus far there are no statistically significant differences between various apolipoprotein E genotypes in the cluster of seven responsiveness to a flaxseed oil supplement in persons with type 2 diabetes
PubMed ID: 40958692
Flaxseed oil significantly reduced platelet aggregability in T2D — a meaningful cardiovascular risk–related effect.
- Unsaturated Fatty Acids Improve Atherosclerosis Markers in Obese and Overweight Non-diabetic Elderly Patients
PubMed ID: 28470492
90‑day flax oil in overweight/obese elderly reduced carotid intima‑media thickness (CIMT), an objective vascular/atherosclerosis marker.
- Comparison of the effects of flaxseed oil and sunflower seed oil consumption on serum glucose, lipid profile, blood pressure, and lipid peroxidation in patients with metabolic syndrome
PubMed ID: 29229363
25 mL/day flax oil for 7 weeks produced large, statistically significant reductions in systolic and diastolic BP in metabolic‑syndrome patients.
- Effects of Flaxseed Oil on Serum Lipids and Lipoproteins in Hemodialysis Patients: a Randomized Controlled Trial
PubMed ID: 27904000
6 g/day flax oil in hemodialysis patients markedly lowered triglycerides (cardiovascular risk factor).
- Additive effect of linseed oil supplementation on the lipid profiles of older adults
PubMed ID: 26543357
Low‑dose linseed oil plus diet advice improved total/LDL/TG and raised HDL in older adults (lipid improvements relevant to heart health).
- High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects
PubMed ID: 20875216
Flaxseed‑containing oil blends substantially lowered LDL and total cholesterol and reduced an endothelial inflammation marker in hypercholesterolaemic adults.
Cholesterol (9)
- The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression of lipoprotein(a) and oxidized low-density lipoprotein, lipid profiles and biomarkers of oxidative stress in patients with polycystic ovary syndrome
PubMed ID: 27619403
Triglycerides, total cholesterol and LDL were reduced in PCOS women (co-supplemented with vitamin E).
- Lignan content of the flaxseed influences its biological effects in healthy men and women
PubMed ID: 23885993
High-lignan flaxseed bars produced clinically meaningful reductions in total and LDL cholesterol.
- Benefits of foods supplemented with vegetable oils rich in α-linolenic, stearidonic or docosahexaenoic acid in hypertriglyceridemic subjects: a double-blind, randomized, controlled trail
PubMed ID: 25216712
Linseed oil foods reduced total and LDL cholesterol in hypertriglyceridemic adults (erythrocyte EPA rose).
- Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension
PubMed ID: 1972963
Linseed‑oil diet for 2 weeks in men with mild hypertension significantly decreased total cholesterol, LDL and triglycerides (clear lipid improvements).
- Effects of olive oil and flaxseed consumption in a healthy diet on endothelial function, plasma lipids and inflammatory factors of patients with coronary heart disease: a randomized clinical trial
PubMed ID: 37335239
CHD trial reported a significant decrease in total cholesterol alongside improved endothelial function and inflammation.
- Effects of Flaxseed Oil on Serum Lipids and Lipoproteins in Hemodialysis Patients: a Randomized Controlled Trial
PubMed ID: 27904000
6 g/day flax oil for 8 weeks in hemodialysis patients produced a marked ~23% reduction in serum triglycerides (important lipid risk factor).
- Additive effect of linseed oil supplementation on the lipid profiles of older adults
PubMed ID: 26543357
3 g/day linseed oil for 12 weeks (plus dietary guidance) produced reductions in total cholesterol, LDL and TG and increased HDL in older adults.
- High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects
PubMed ID: 20875216
Flaxseed‑containing oil blends substantially lowered LDL and total cholesterol and improved an endothelial inflammation marker in hypercholesterolaemic adults.
- Metabolic response to omega-3 fatty acid supplementation in patients with diabetic nephropathy: A randomized, double-blind, placebo-controlled trial
PubMed ID: 26611718
Flaxseed oil reduced triglycerides/VLDL in diabetic nephropathy; triglyceride lowering contributes to overall lipid health.
Blood sugar (7)
- Effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acids on erythrocyte fatty acid composition in type 2 diabetic patients
PubMed ID: 35144649
Perilla/linseed (plant n-3) modestly improved fasting glucose in a 6-month RCT in T2DM patients.
- The Effects of Omega-3 Fatty Acids and Vitamin E Co-Supplementation on Indices of Insulin Resistance and Hormonal Parameters in Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 28407657
Improved insulin and HOMA-IR in PCOS women with flax-derived omega-3 + vitamin E.
- A comparison between the effects of flaxseed oil and fish oil supplementation on cardiovascular health in type 2 diabetic patients with coronary heart disease: A randomized, double-blinded, placebo-controlled trial
PubMed ID: 31190359
T2D with coronary disease sample had insulin reduction and other metabolic marker improvements—supports glycemic benefits.
- The Effects of Flaxseed Oil Omega-3 Fatty Acids Supplementation on Metabolic Status of Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 29117618
PCOS trial: improved fasting insulin and HOMA‑IR—relevant to glycemic stability in metabolic syndrome/PCOS.
- Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial
PubMed ID: 28716357
Diabetic foot ulcer trial reported improved insulin, HOMA‑IR and HbA1c—clinically relevant glycemic improvements.
- Metabolic response to omega-3 fatty acid supplementation in patients with diabetic nephropathy: A randomized, double-blind, placebo-controlled trial
PubMed ID: 26611718
Randomized double‑blind trial in diabetic nephropathy showed substantial improvements in insulin, HOMA‑B, QUICKI and lowered triglycerides—strong glycemic benefits.
- A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids and vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes
PubMed ID: 27055970
Gestational diabetes trial (omega‑3 + vit E) improved fasting glucose, insulin and HOMA‑IR—beneficial though co‑supplement confounds attribution.
Antioxidant (7)
- A comparison between the effects of flaxseed oil and fish oil supplementation on cardiovascular health in type 2 diabetic patients with coronary heart disease: A randomized, double-blinded, placebo-controlled trial
PubMed ID: 31190359
T2D with CAD: flaxseed oil increased total antioxidant capacity (TAC) and reduced hs‑CRP—supports antioxidant effects.
- The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial
PubMed ID: 28342967
Parkinson's trial reported increased TAC and reduced hs‑CRP—antioxidant and anti‑inflammatory signals.
- A Randomized Controlled Clinical Trial Investigating the Effects of Omega-3 Fatty Acids and Vitamin E Co-Supplementation on Biomarkers of Oxidative Stress, Inflammation and Pregnancy Outcomes in Gestational Diabetes
PubMed ID: 27881297
Gestational diabetes trial (omega‑3 + vit E) markedly increased TAC and NO and lowered MDA—strong antioxidant biomarker changes (vit E confound).
- The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression of lipoprotein(a) and oxidized low-density lipoprotein, lipid profiles and biomarkers of oxidative stress in patients with polycystic ovary syndrome
PubMed ID: 27619403
Downregulation of Ox-LDL mRNA suggests reduced oxidative-lipid stress signaling.
- Lignan content of the flaxseed influences its biological effects in healthy men and women
PubMed ID: 23885993
High-lignan flaxseed bars substantially lowered oxidized LDL (Ox-LDL), a marker of oxidative stress.
- Differential effect of cheese fatty acid composition on blood lipid profile and redox status in normolipidemic volunteers: a pilot study
PubMed ID: 21591986
Eating cheese from linseed‑fed cows increased blood antioxidant vitamins C and E and lowered oxidized LDL in healthy volunteers.
- Comparison of the effects of flaxseed oil and sunflower seed oil consumption on serum glucose, lipid profile, blood pressure, and lipid peroxidation in patients with metabolic syndrome
PubMed ID: 29229363
Flax oil reduced malondialdehyde (MDA) — an index of lipid peroxidation — versus sunflower oil in metabolic‑syndrome patients (trend).
Wellbeing (6)
- Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis
PubMed ID: 31519285
Flaxseed (ground and oil) improved disease activity and quality‑of‑life measures in ulcerative colitis.
- Effects of flaxseed oil on blood hepcidin and hematologic factors in hemodialysis patients
PubMed ID: 27885786
Improved hemoglobin and RBC counts in anemic dialysis patients likely improved overall wellbeing and fatigue.
- Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial
PubMed ID: 28716357
Reduced diabetic ulcer size and improved metabolic/inflammatory status can substantially improve patient well‑being.
- An artificial tear containing flaxseed oil for treating dry eye disease: A randomized controlled trial
PubMed ID: 31734510
Multicenter RCT: flaxseed‑oil nano‑emulsion artificial tear improved ocular staining and symptoms—which can improve quality of life.
- Effects of olive oil and flaxseed consumption in a healthy diet on endothelial function, plasma lipids and inflammatory factors of patients with coronary heart disease: a randomized clinical trial
PubMed ID: 37335239
CHD RCT: improved endothelial function, reduced inflammation and lowered cholesterol likely to benefit overall health/well‑being.
- The effects of flaxseed supplementation on gene expression and inflammation in ulcerative colitis patients: An open-labelled randomised controlled trial
PubMed ID: 33482045
Quality-of-life measures improved in UC patients alongside lower inflammation and disease activity.
Hormone balance (6)
- Contribution of linseed intake to urine and serum enterolignan levels in German females: a randomised controlled intervention trial
PubMed ID: 16494982
Daily 20 g ground linseed for 2 months markedly raised circulating enterolignans (phytoestrogen precursors) in women — strong biomarker for hormone‑modulating potential.
- The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression of lipoprotein(a) and oxidized low-density lipoprotein, lipid profiles and biomarkers of oxidative stress in patients with polycystic ovary syndrome
PubMed ID: 27619403
PCOS trial showed favorable gene expression and lipid changes, relevant to endocrine/metabolic aspects of PCOS.
- The Effects of Omega-3 Fatty Acids and Vitamin E Co-Supplementation on Indices of Insulin Resistance and Hormonal Parameters in Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 28407657
In PCOS women, flax-derived omega-3 + vitamin E lowered total/free testosterone and improved insulin resistance.
- Effect of supplementation with different fat sources on the mechanisms involved in reproductive performance in lactating dairy cattle
PubMed ID: 22464816
Dairy‑cow study: n‑3 supplements (including flax) lowered plasma progesterone and reduced CL size—evidence of endocrine effects (animal).
- The Effects of Flaxseed Oil Omega-3 Fatty Acids Supplementation on Metabolic Status of Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 29117618
PCOS trial: improved insulin and reduced hirsutism score—clinically meaningful effects on endocrine/hormonal manifestations in women.
- Effects of flaxseed oil supplementation on metaphase II oocyte rates in IVF cycles with decreased ovarian reserve: a randomized controlled trial
PubMed ID: 38469148
Improved oocyte maturity, fertilization and implantation rates in women with low ovarian reserve suggest an effect on reproductive/hormonal biology.
Immune support (4)
- Flaxseed Oil Supplementation Improve Gene Expression Levels of PPAR-γ, LP(a), IL-1 and TNF-α in Type 2 Diabetic Patients with Coronary Heart Disease
PubMed ID: 28916975
Reduced PBMC inflammatory cytokine mRNAs (IL-1, TNF-α) indicating immune-modulatory effects.
- Effects of diacylglycerol-enriched alpha-linolenic acid oil on skin properties in mild skin discomfort: a randomized, double-blind, placebo-controlled study
PubMed ID: 41495414
Suppressed mite-specific IgE rise and improved skin symptoms, indicating immunomodulation in allergic responses.
- The effects of flaxseed supplementation on gene expression and inflammation in ulcerative colitis patients: An open-labelled randomised controlled trial
PubMed ID: 33482045
In UC patients, flaxseed/oil lowered hs-CRP and increased IL-10, indicating immune modulation/reduced inflammatory immune activity.
- Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis
PubMed ID: 31519285
Flaxseed (oil and ground) lowered inflammatory cytokines and disease activity in ulcerative colitis, indicating immune modulation.
Eye health (3)
- An artificial tear containing flaxseed oil for treating dry eye disease: A randomized controlled trial
PubMed ID: 31734510
Large multicenter RCT: flaxseed‑oil nano‑emulsion artificial tear significantly improved ocular staining and was safe—direct human evidence.
- Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye
PubMed ID: 21045648
Omega‑3 supplement containing flaxseed oil improved dry‑eye symptoms and tear production vs placebo (human RCT, co‑formulated with fish oil).
- [Oral flaxseed oil (Linum usitatissimum) in the treatment for dry-eye Sjögren's syndrome patients]
PubMed ID: 17906762
Oral flaxseed oil (1–2 g/day) for 180 days reduced symptoms and objective signs of dry eye in Sjögren's syndrome patients in an RCT.
Digestive support (3)
- The effects of flaxseed supplementation on gene expression and inflammation in ulcerative colitis patients: An open-labelled randomised controlled trial
PubMed ID: 33482045
In ulcerative colitis patients, flaxseed (seed and oil) reduced disease severity (Mayo score) and improved QoL, indicating clear GI benefit.
- The short-term effects of olive oil and flaxseed oil for the treatment of constipation in hemodialysis patients
PubMed ID: 25238699
Daily flaxseed oil improved stool frequency and consistency in constipated hemodialysis patients (Rome III outcomes).
- Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis
PubMed ID: 31519285
Flaxseed (whole and oil) reduced disease activity and fecal calprotectin in ulcerative colitis — direct GI benefit.
Joint comfort (3)
- A Topical Gel From Flax Seed Oil Compared With Hand Splint in Carpal Tunnel Syndrome: A Randomized Clinical Trial
PubMed ID: 27909031
Topical flaxseed oil gel significantly improved symptoms and function in mild–moderate carpal tunnel versus splinting.
- Effects of olive oil and flaxseed consumption in a healthy diet on endothelial function, plasma lipids and inflammatory factors of patients with coronary heart disease: a randomized clinical trial
PubMed ID: 37335239
Reduction in systemic inflammatory markers (IL‑6, TNF‑α) in CHD trial supports anti‑inflammatory effects relevant to joints.
- Effect of Linum usitatissimum L. (linseed) oil on mild and moderate carpal tunnel syndrome: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 24887185
Topical linseed oil + splint produced clinically meaningful symptomatic and functional improvement in carpal tunnel patients.
Menstrual comfort (3)
- The Effects of Flaxseed Oil Omega-3 Fatty Acids Supplementation on Metabolic Status of Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 29117618
In PCOS, flaxseed oil improved insulin resistance and hirsutism (mF‑G score)—clinically relevant to menstrual/hormonal symptoms though menstrual bleeding/regularity not directly reported.
- The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression of lipoprotein(a) and oxidized low-density lipoprotein, lipid profiles and biomarkers of oxidative stress in patients with polycystic ovary syndrome
PubMed ID: 27619403
PCOS study showed improved lipid/inflammatory gene expression; may support menstrual/ovulatory health.
- The Effects of Omega-3 Fatty Acids and Vitamin E Co-Supplementation on Indices of Insulin Resistance and Hormonal Parameters in Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 28407657
In PCOS women, combined flax-derived omega-3 + vitamin E lowered total/free testosterone and improved insulin, relevant to menstrual/PCOS symptoms.
Cell health (3)
- Lignan content of the flaxseed influences its biological effects in healthy men and women
PubMed ID: 23885993
Reduction in Ox-LDL indicates decreased lipid oxidative damage, relevant to cell protection.
- Flaxseed Oil Supplementation Improve Gene Expression Levels of PPAR-γ, LP(a), IL-1 and TNF-α in Type 2 Diabetic Patients with Coronary Heart Disease
PubMed ID: 28916975
PBMC gene changes (↑PPAR-γ, ↓inflammatory genes) suggest cellular protective signaling.
- Effects of Omega-3 Fatty Acid Supplementation on Inflammatory Cytokines and Advanced Glycation End Products in Patients With Diabetic Nephropathy: a Randomized Controlled Trial
PubMed ID: 27514766
Flaxseed oil reduced circulating AGEs in diabetic nephropathy—direct marker of reduced glycation/long‑term cellular damage risk.
Brain health (2)
- The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial
PubMed ID: 28342967
Parkinson's patients given flaxseed omega‑3 + vit E had modest motor score improvements and improved antioxidant/inflammatory markers—direct CNS clinical trial.
- Supplementation with Flaxseed Oil Rich in Alpha-Linolenic Acid Improves Verbal Fluency in Healthy Older Adults
PubMed ID: 36986229
12-week RCT in older adults showed a modest but significant improvement in verbal fluency with flaxseed oil (ALA).
Skin hydration (1)
- Effects of diacylglycerol-enriched alpha-linolenic acid oil on skin properties in mild skin discomfort: a randomized, double-blind, placebo-controlled study
PubMed ID: 41495414
ALA-DAG (flax-derived) increased cheek skin conductance and improved itch scores in an RCT.
Energy & Fatigue (1)
- Effects of flaxseed oil on blood hepcidin and hematologic factors in hemodialysis patients
PubMed ID: 27885786
Lowered hepcidin and raised hemoglobin/RBC in dialysis patients — plausible fatigue/energy benefit from improved anemia.
Weight management (1)
- Dietary milled flaxseed and flaxseed oil improve N-3 fatty acid status and do not affect glycemic control in individuals with well-controlled type 2 diabetes
PubMed ID: 20595648
Flaxseed oil/milled flax prevented a small weight gain compared with control in people with well‑controlled T2D (practical weight‑support signal).
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Flaxseed Oil
Search all706 products whose verified label declares Flaxseed Oil — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.