L-Histidine
16 benefits mapped to clinical evidence across supplements.
Dose per serving from products
1,592 products in our catalogue print how much L-Histidine a serving holds.
Most common: 250 mg to 500 mg, 30% of 1,592 products.
| Dose per serving | Products |
|---|---|
| 5 mg or less | 15 |
| 5 mg to 10 mg | 180 |
| 10 mg to 25 mg | 100 |
| 25 mg to 50 mg | 132 |
| 50 mg to 100 mg | 219 |
| 100 mg to 250 mg | 211 |
| 250 mg to 500 mg | 474 |
| 500 mg to 1 g | 178 |
| 1 g to 2.5 g | 78 |
| over 2.5 g | 5 |
Benefit Evidence
Digestive support: histidine digestion
Digestive support: bowel relief
Research sources
Metabolism (11)
- Magnesium and imidazole propionate
PubMed ID: 33487303
Mg intervention lowered ImP, a histidineâderived microbial metabolite implicated in insulin resistanceâdirect, randomized evidence relevant to metabolic health.
- A plant-based diet in overweight individuals in a 16-week randomized clinical trial: metabolic benefits of plant protein
PubMed ID: 30405108
Direct association between decreased histidine intake and improved insulin resistance (HOMAâIR) independent of weight â strong metabolic relevance.
- Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout
PubMed ID: 21847611
Doseâresponse increases in muscle carnosine after β-alanine imply improved muscle pH buffering and gradual washoutârelevant to acidâbase support.
- Effect of metformin therapy on circulating amino acids in a randomized trial: the CAMERA study
PubMed ID: 26887663
Randomized metformin trial produced a small sustained rise in histidine alongside other metabolic AA changesâlinks histidine alterations to metabolic intervention.
- Effects of Histidine Supplementation on Global Serum and Urine (1)H NMR-based Metabolomics and Serum Amino Acid Profiles in Obese Women from a Randomized Controlled Study
PubMed ID: 28447460
Randomized histidine supplementation in obese women shifted amino-acid and lipid/glucose signals (lowered cholesterol/triglyceride/glucose signatures), supporting metabolic benefit.
- Circulating amino acids and the risk of macrovascular, microvascular and mortality outcomes in individuals with type 2 diabetes: results from the ADVANCE trial
PubMed ID: 29728717
Higher plasma histidine associated with lower mortality in T2D, consistent with a favorable metabolic-health marker.
- Clinical impact of histidine-ketoglutarate-tryptophan (HTK) cardioplegic solution on the perioperative period in open heart surgery patients
PubMed ID: 11440787
HTK cardioplegia (histidine-based buffer) improved clinical cardiac surgery outcomes, reflecting histidineâs role in preservation/buffering during ischemia.
- Empagliflozin increases plasma levels of citrulline, histidine, and Îą-aminobutyric acid in patients with type 2 diabetes: effects of a sodium-glucose co-transporter 2 inhibitor on the plasma amino acid profile
PubMed ID: 38809611
Empagliflozin RCT in T2D increased plasma histidine and improved metabolic markers (Fischer ratio, PAIâ1)âstrongest direct metabolic signal.
- Carnosine supplementation improves glucose control in adults with pre-diabetes and type 2 diabetes: A randomised controlled trial
PubMed ID: 38172006
Carnosine supplementation reduced postâOGTT glucose and glucose AUC in prediabetes/T2D, directly supporting metabolic health.
- Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: a randomised controlled trial
PubMed ID: 23361591
Highâquality RCT: 4 g/day histidine for 12 weeks in obese women improved HOMAâIR, reduced fat mass and inflammatory markersâstrong metabolic health evidence.
- Renal perfusion with histidine-tryptophan-ketoglutarate compared with Ringer's solution in patients undergoing thoracoabdominal aortic open repair
PubMed ID: 33820636
Custodiol (histidineâtryptophanâketoglutarate) is a histidineâbuffered organ perfusion solution; trial showed reduced AKIâbuffer role relevant to acidâbase/organ protection.
Immune support (8)
- Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis: a phase-2 multi-center study
PubMed ID: 11895545
Larger histatinâpeptide trial showed reduced gingival bleeding and improvements in higherârisk subjectsâsupports local immune/antimicrobial activity.
- Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: a randomised controlled trial
PubMed ID: 23361591
Oral Lâhistidine reduced inflammatory cytokines (TNFâÎą, ILâ6) in obese womenâsystemic antiâinflammatory effect relevant to immune status.
- [Impact of intravenous nutrition on plasma free amino acid spectrum and immune function for patients with sepsis]
PubMed ID: 17571315
IV amino acids in sepsis raised some immune markers (IgM, C3, C4); histidine rose but remained below controlsâsupports AA interventions affecting immunity.
- The Effects of Antimicrobial Peptide Nal-P-113 on Inhibiting Periodontal Pathogens and Improving Periodontal Status
PubMed ID: 29736391
Histidineârich antimicrobial peptide reduced periodontal pathogens and inflammation (bleeding), demonstrating an immune/antimicrobial benefit.
- Differential effects of three enteral dietary regimens on selected outcome variables in burn patients
PubMed ID: 2112634
Enriched enteral feeding (arginine, cysteine, histidine, etc.) reduced wound infections in burn patientsâclinical immune/hostâdefense effect though contribution of histidine alone is uncertain.
- Intracellular amino acid concentrations in children with chronic renal insufficiency
PubMed ID: 8611355
Children with chronic renal failure had lower intracellular histidine in granulocytes vs controlsâdirect measurement linking histidine status and immune cell aminoâacid content.
- Reduction in Pain and Inflammation Associated With Chronic Low Back Pain With the Use of the Medical Food Theramine
PubMed ID: 25237981
Medical food containing histidine reduced CRP and ILâ6 in chronic low back pain patientsâclear antiâinflammatory/immune biomarker changes concurrent with symptom improvement.
- Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis
PubMed ID: 11350502
Histatin (histidineârich peptide) mouthrinse reduced plaque/gingivitis, reflecting antimicrobial/local immune effects.
Muscle maintenance (7)
- Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout
PubMed ID: 21847611
Doseâdependent increases in muscle carnosine after β-alanine imply improved muscle buffering and maintenance potential.
- Prospective study on the efficacy of branched-chain amino acids in septic patients
PubMed ID: 1907675
HighâBCAA nutrition improved nitrogen balance and reduced urinary 3MH in septic patientsâsupports preservation of muscle.
- Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training
PubMed ID: 8941534
HMB during resistance training reduced 3MH and increased lean mass/strengthâstrong relevance to muscle maintenance (aminoâacid pathway).
- Protein bioavailability of Wolffia globosa duckweed, a novel aquatic plant - A randomized controlled trial
PubMed ID: 30591380
Mankai meal increased circulating EAAs (including histidine) vs comparatorsâsupports substrate availability for muscle.
- Independent and combined effects of liquid carbohydrate/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men
PubMed ID: 16456674
CHO+essential AAs (includes histidine) during resistance training reduced 3âmethylhistidine (less breakdown) and increased fiber CSAâsupports muscle maintenance (histidine part of mixture).
- Liquid carbohydrate/essential amino acid ingestion during a short-term bout of resistance exercise suppresses myofibrillar protein degradation
PubMed ID: 16631431
Acute trial: CHO+EAA suppressed postâexercise protein breakdown vs placebo; histidine was one componentâsupports antiâcatabolic effects.
- Nitrogen balance, 3-methylhistidine excretion, and plasma amino acid profile in infants after cardiac operations for congenital heart defects: the effect of early nutritional support
PubMed ID: 9434700
Early postoperative parenteral AA in infants reduced protein breakdown and improved nitrogen balanceâsupports tissue/muscle maintenance in growth context.
Cell health (5)
- Safety and clinical effects of topical histatin gels in humans with experimental gingivitis
PubMed ID: 12492903
Topical histatin (histidineârich peptide) significantly reduced bleeding on probing in experimental gingivitis â direct clinical evidence for benefit to oral mucosal health.
- The Effects of Antimicrobial Peptide Nal-P-113 on Inhibiting Periodontal Pathogens and Improving Periodontal Status
PubMed ID: 29736391
Topical histidineârich peptide gel significantly improved periodontal pocket depth, bleeding and reduced key pathogensâdirect mucosal benefit.
- Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis: a phase-2 multi-center study
PubMed ID: 11895545
Large phaseâ2 trial: histatinâbased (histidineârich) mouthrinse reduced gingival bleeding and improved oral healthâstrong, direct mucosal benefit.
- Antidiarrheal effects of L-histidine-supplemented rice-based oral rehydration solution in the treatment of male adults with severe cholera in Bangladesh: a double-blind, randomized trial
PubMed ID: 15809910
Lâhistidine added to ORS in cholera improved diarrheal outcomesâdirect benefit to intestinal mucosa and mucous membrane health.
- Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis
PubMed ID: 11350502
Randomized trial: histatin peptide mouthrinse safe and modestly reduced plaque/gingivitisâdirect oral mucosal support.
Joints & tendons (6)
- Nitrogen balance, 3-methylhistidine excretion, and plasma amino acid profile in infants after cardiac operations for congenital heart defects: the effect of early nutritional support
PubMed ID: 9434700
Early postoperative AA infusion reduced proteolysis and improved nitrogen balance in infantsâsupports tissue repair.
- Renal perfusion with histidine-tryptophan-ketoglutarate compared with Ringer's solution in patients undergoing thoracoabdominal aortic open repair
PubMed ID: 33820636
Custodiol (histidineâcontaining) renal perfusion markedly reduced postoperative AKI vs Ringer'sâstrong organ/tissue protection in surgical setting (solution context).
- Randomized clinical assay for hepatic grafts preservation with University of Wisconsin or histidine-tryptophan-ketoglutarate solutions in liver transplantation
PubMed ID: 16908310
Organ graft preservation solution (HTK) contains histidine; trial compared graft outcomesâhistidine part of protective solution (multiple components confound attribution).
- Differential effects of three enteral dietary regimens on selected outcome variables in burn patients
PubMed ID: 2112634
Modular highâprotein enteral feed (including histidine) reduced wound infections and length of stay in burn patientsâdirect clinical relevance to wound healing/tissue repair (multiple nutrients included).
- Comparison Between Histidine-Tryptophan-Ketoglutarate Cardioplegia and Cold Blood Cardioplegia for Myocardial Protection in Tetralogy of Fallot Patients Undergoing Surgical Repair: A Randomized Clinical Trial
PubMed ID: 39174372
Histidineâcontaining HTK cardioplegia reduced troponin release and improved early RV function after pediatric cardiac surgeryâevidence of tissue (myocardial) protection.
- The Effects of Antimicrobial Peptide Nal-P-113 on Inhibiting Periodontal Pathogens and Improving Periodontal Status
PubMed ID: 29736391
Histidineârich antimicrobial peptide gel improved periodontal pocket depth, bleeding and reduced pathogensâevidence for local tissue healing/repair.
Energy & Fatigue (5)
- Effects of Histidine Supplementation on Global Serum and Urine (1)H NMR-based Metabolomics and Serum Amino Acid Profiles in Obese Women from a Randomized Controlled Study
PubMed ID: 28447460
12-week histidine supplementation in obese women lowered serum metabolomic signals related to cholesterol, triglycerides, fatty acids and glucoseâdirect metabolic effects.
- Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: a randomised controlled trial
PubMed ID: 23361591
4 g/day histidine for 12 weeks improved HOMAâIR, reduced fat mass and NEFAâstrong evidence for metabolic/energy regulation.
- A plant-based diet in overweight individuals in a 16-week randomized clinical trial: metabolic benefits of plant protein
PubMed ID: 30405108
In overweight adults, decreased dietary histidine intake correlated with improved HOMAâIR and reduced fat mass â direct metabolic health evidence.
- Carnosine supplementation improves glucose control in adults with pre-diabetes and type 2 diabetes: A randomised controlled trial
PubMed ID: 38172006
Daily carnosine (2 g) significantly lowered 90/120âmin glucose and total glucose AUC in prediabetes/T2Dâdirect metabolic benefit.
- Effects of oral administration of orodispersible levo-carnosine on quality of life and exercise performance in patients with chronic heart failure
PubMed ID: 25287762
Lâcarnosine improved peak VO2 and 6âmin walk distance in heart failure, indicating improved energy/functional metabolism.
Nutrition source (4)
- Magnesium and imidazole propionate
PubMed ID: 33487303
Randomized trial of personalized magnesium supplementation produced causal reductions in imidazole propionate (a histidine microbial metabolite), demonstrating an interaction between magnesium and histidine metabolismâstrong relevance to mineralâhistidine interactions.
- Dietary amino acids and blood pressure: a cohort study of patients with cardiovascular disease
PubMed ID: 22381643
Cohort data: higher dietary histidine modestly associated with lower systolic/diastolic blood pressureâsupporting a role in cardiovascular/blood function.
- Comparison between the Effects of Bretschneider's HTK Solution and Cold Blood Cardioplegia on Systemic Endothelial Functions in Patients who Undergo Coronary Artery Bypass Surgery: a Prospective Randomized and Controlled Trial
PubMed ID: 33118727
In CABG patients HTK (histidineâcontaining) preserved systemic endothelial function better than cold blood cardioplegia (improved FMD, lower ETâ1)âstrong relevance to vascular/blood function.
- Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZINâ˘, zinc acetate dihydrate) for patients with hypozincemia
PubMed ID: 39705879
Zincâhistidine hydrate performed comparably to zinc acetate for maintaining serum zinc with fewer GI effectsâdirect evidence that histidine can form efficacious mineral complexes.
Skin repair (4)
- The Effects of Antimicrobial Peptide Nal-P-113 on Inhibiting Periodontal Pathogens and Improving Periodontal Status
PubMed ID: 29736391
Topical histidine-rich antimicrobial peptide improved periodontal healing markers in a splitâmouth RCTâdirect mucosal wound repair evidence.
- Evaluation of a Novel Graft-Holding Solution in Hair Transplantation: A Randomized Controlled Clinical Study
PubMed ID: 37036372
Hair graft storage in a histidineâbased HTKâAD solution reduced early shedding and accelerated regrowth vs Ringerâclear functional improvement in skin/graft outcomes linked to a histidineâcontaining formulation.
- Ultraviolet light hardening in polymorphous light eruption--a controlled study comparing different emission spectra
PubMed ID: 1756116
UV hardening increased skin histidine/urocanic acid and improved photoprotectionâhistidine metabolites relevant to skin defense.
- Nitrogen balance, 3-methylhistidine excretion, and plasma amino acid profile in infants after cardiac operations for congenital heart defects: the effect of early nutritional support
PubMed ID: 9434700
Parenteral amino acids in infants lowered proteolysis and improved nitrogen balanceânutritional support that would favor wound/tissue healing.
Exercise recovery (5)
- Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout
PubMed ID: 21847611
Doseâdependent carnosine increases after β-alanine suggest improved buffering aiding recovery (human trial data).
- Liquid carbohydrate/essential amino acid ingestion during a short-term bout of resistance exercise suppresses myofibrillar protein degradation
PubMed ID: 16631431
CHO+EAA before/during resistance exercise markedly suppressed exerciseâinduced protein breakdown; histidine was a componentâsupports recovery.
- Independent and combined effects of liquid carbohydrate/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men
PubMed ID: 16456674
Combination of CHO+EAAs reduced markers of muscle breakdown and promoted fiber growthârecoveryârelevant (histidine part of mixture).
- Effects of oral administration of orodispersible levo-carnosine on quality of life and exercise performance in patients with chronic heart failure
PubMed ID: 25287762
Six months oral Lâcarnosine improved 6âmin walk distance and peak VO2 in heart failure, indicating improved exercise capacity/recovery.
- Comparison of Two β-Alanine Dosing Protocols on Muscle Carnosine Elevations
PubMed ID: 28910200
Sustainedârelease β-alanine raised muscle carnosine (exercise recovery mechanism) while lowering plasma histidine at high dose.
Healthy aging (3)
- Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: a randomised controlled trial
PubMed ID: 23361591
12âweek oral Lâhistidine in obese women improved insulin resistance, inflammation and adiponectinâmetabolic changes relevant to healthy aging.
- N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts
PubMed ID: 11390029
Nâacetylcarnosine eye drops improved cataractârelated vision outcomes, an ageârelated condition.
- Circulating amino acids and the risk of macrovascular, microvascular and mortality outcomes in individuals with type 2 diabetes: results from the ADVANCE trial
PubMed ID: 29728717
Large cohort found higher baseline plasma histidine modestly associated with lower all-cause mortality in people with T2D.
Digestive support (3)
- Antidiarrheal effects of L-histidine-supplemented rice-based oral rehydration solution in the treatment of male adults with severe cholera in Bangladesh: a double-blind, randomized trial
PubMed ID: 15809910
Direct RCT: adding Lâhistidine to rice ORS in cholera reduced stool output, frequency and illness durationâstrong digestive benefit.
- Carnosine treatment for gulf war illness: a randomized controlled trial
PubMed ID: 23618477
Oral carnosine reduced diarrhea/IBS symptom categories in some Gulf War illness patients (RCT pilot).
- Integrated metabolomic insights into the mechanism of Bacillus coagulans in enhancing intestinal recovery following gynecological laparoscopic surgery: a randomized clinical trial
PubMed ID: 41080557
Perioperative Bacillus coagulans shortened time to first bowel movement and raised motilin/5âHT while altering histidine metabolitesâstrong clinical digestive benefit with linked histidine pathway changes.
Antioxidant (3)
- Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout
PubMed ID: 21847611
Dose-dependent rises in muscle carnosine after β-alanine (histidineâcontaining dipeptide) imply increased antioxidant potential (indirect human evidence).
- N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts
PubMed ID: 11390029
Nâacetylcarnosine (histidineâcontaining) eye drops produced clinical improvements attributed to antioxidant action in cataracts.
- Low-dose histidine-tryptophan-ketoglutarate solution for myocardial protection
PubMed ID: 16213352
HTK (histidine-containing) cardioplegia reduced malondialdehyde and some oxidative markers vs control in CABG patients.
Growth support (2)
- Nitrogen balance, 3-methylhistidine excretion, and plasma amino acid profile in infants after cardiac operations for congenital heart defects: the effect of early nutritional support
PubMed ID: 9434700
Infant postoperative parenteral amino acids reduced protein breakdown and improved nitrogen balanceâdirectly relevant to growth/nutritional support.
- Estimation of the leucine and histidine requirements for piglets fed a low-protein diet
PubMed ID: 27133467
Controlled piglet feeding directly defined standardized ileal digestible histidine requirement for optimal growthâstrong animal evidence.
Nerve health (2)
- Integrated metabolomic insights into the mechanism of Bacillus coagulans in enhancing intestinal recovery following gynecological laparoscopic surgery: a randomized clinical trial
PubMed ID: 41080557
Perioperative probiotic raised plasma serotonin (5âHT) and altered histidine/kynurenine metabolitesâdirect evidence linking histidine pathway changes to neurotransmitter levels.
- Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis
PubMed ID: 28342911
Marked decrease in HDC (histidine decarboxylase) expression during anaphylaxis â direct implication for histamine neurotransmitter synthesis.
Joint comfort (1)
- Reduction in Pain and Inflammation Associated With Chronic Low Back Pain With the Use of the Medical Food Theramine
PubMed ID: 25237981
Randomized medicalâfood trial (multiâAA including histidine) produced marked reductions in pain and inflammatory markers in chronic low back painâclinical improvement in musculoskeletal pain.
Alertness (1)
- Cognitive Benefits of Reducing Indoor Particulate Matter Exposure During Sleep: New Evidence from a Randomized, Double-blind Crossover Trial
PubMed ID: 39546323
Reduction of indoor PM during sleep improved cognitive scores and metabolomics implicated histidine/dopamine metabolismâreasonable indirect support for mental/cognitive effects tied to histidine pathways.
Forms of L-Histidine
The 2 forms a label may print instead of L-Histidine. Each is a different substance with its own identifier, and none of them has research of its own â the studies are the ones on this page.
Similar by evidence
Supplements the same benefits carry qualifying findings for â a fact about the evidence graph, not a recommendation to swap.
Products with L-Histidine
Search all2450 products whose verified label declares L-Histidine â not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet â this is what the field is asking, not what it found.