Coenzyme Q10
17 benefits mapped to clinical evidence across supplements.
Dose per serving from products
4,865 products in our catalogue print how much Coenzyme Q10 a serving holds.
Most common: 50 mg to 100 mg, 35% of 4,865 products.
| Dose per serving | Products |
|---|---|
| 2.5 mg or less | 158 |
| 2.5 mg to 5 mg | 158 |
| 5 mg to 10 mg | 294 |
| 10 mg to 25 mg | 362 |
| 25 mg to 50 mg | 808 |
| 50 mg to 100 mg | 1,686 |
| 100 mg to 250 mg | 951 |
| 250 mg to 500 mg | 359 |
| over 500 mg | 89 |
Dose per serving from research
239 study groups in 185 studies say how much Coenzyme Q10 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 100 mg to 250 mg, 39% of 239 study groups.
| Daily dose | Study groups |
|---|---|
| 25 mg or less | 10 |
| 25 mg to 50 mg | 17 |
| 50 mg to 100 mg | 62 |
| 100 mg to 250 mg | 94 |
| 250 mg to 500 mg | 40 |
| 500 mg to 1 g | 10 |
| over 1 g | 6 |
Commonly used together
69 of 242 study groups took Coenzyme Q10 with something else. Shown: what 3 or more different studies gave. The 10 most common of 14.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Selenium | 21 |
| Vitamin E | 15 |
| Niacin | 10 |
| Omega-3 Fatty Acids | 9 |
| Folic Acid | 8 |
| Red Yeast Rice | 8 |
| Riboflavin | 8 |
| Vitamin C | 8 |
| Berberine | 5 |
| Policosanol | 4 |
Benefit Evidence
Inflammation/oxidative stress ↓
Antiviral/immune response ↑
Infection outcomes ↓
Aerobic capacity +13%
Endurance/walking improved
Fatigue/symptoms down
Wrinkles/density +16.1%
Psoriasis/aging severity
Hydration/sebum↑, MMP-1↓
Inflammation/oxidative stress ↓
Antiviral/immune response ↑
Infection outcomes ↓
Aerobic capacity +13%
Endurance/walking improved
Fatigue/symptoms down
Research sources
Heart health (50)
- Coenzyme Q10 and antioxidants in acute myocardial infarction
PubMed ID: 7752825
Antioxidant therapy including CoQ10 in recent MI reduced QT prolongation and was associated with fewer cardiac deaths over 1 year (clinical cardiac protection signal).
- Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
PubMed ID: 22626835
5-year randomized trial (selenium+CoQ10) showed markedly reduced cardiovascular mortality and improved NT-proBNP and echocardiographic function (combined intervention).
- Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial
PubMed ID: 21388622
In ischemic LV dysfunction, CoQ10 improved endothelial function and mitochondrial markers — strong support for cardiac benefits.
- Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease
PubMed ID: 21996047
In CAD patients, CoQ10 lowered MDA and increased antioxidant enzymes — favorable myocardial/vascular biochemical profile.
- Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomised trial
PubMed ID: 20674497
Perioperative metabolic therapy that included CoQ10 reduced troponin I and shortened hospital stay after cardiac surgery (multicomponent intervention).
- Coenzyme Q10 improves diastolic function in children with idiopathic dilated cardiomyopathy
PubMed ID: 19703336
Randomized trial in children with idiopathic dilated cardiomyopathy showed improved diastolic function and clinical heart-failure scores on CoQ10—strong clinical heart outcome evidence (small sample).
- The role of oral coenzyme Q10 in patients undergoing coronary artery bypass graft surgery
PubMed ID: 18834786
Perioperative CoQ10 was associated with fewer reperfusion arrhythmias and lower inotropic requirement after CABG—cardiac-protection signal.
- Coenzyme Q10 in patients undergoing CABG: Effect of statins and nutritional supplementation
PubMed ID: 17368873
CoQ10 supplementation increased cardiac tissue CoQ10 concentrations—directly relevant to myocardial function and vitality.
- Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study
PubMed ID: 17644511
Improved endothelial antioxidant activity and vasodilation in CAD indicates cardiovascular benefit.
- Coenzyme Q10 combined with mild hypothermia after cardiac arrest: a preliminary study
PubMed ID: 15520321
Adjunctive CoQ10 with hypothermia after cardiac arrest markedly improved 3‑month survival and neurological outcome — strong clinically meaningful effect on cardiac arrest outcomes.
- Complementary therapy in diabetic patients with chronic complications: a pilot study
PubMed ID: 20586147
Pilot randomized study in diabetics found antioxidant supplementation including CoQ10 improved left ventricular function parameters and reduced oxidative markers (small combined trial).
- [Observation on collaborative treatment of dilated cardiomyopathy]
PubMed ID: 12577349
Large integrative therapy trials that included CoQ10 among many agents for dilated cardiomyopathy reported improved symptoms and reduced short‑term deaths—multi‑component evidence consistent with cardiac benefit.
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
High‑dose ubiquinol (600 mg/day) in HFpEF improved KCCQ clinical status, EF (+7.08%) and BNP, plus ATP biomarkers — strong heart benefit.
- Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction
PubMed ID: 9825179
CoQ10 (120 mg/day) after AMI associated with fewer angina episodes, arrhythmias and composite cardiac events vs placebo.
- Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease
PubMed ID: 10204818
Hydrosoluble CoQ10 added to antihypertensive therapy improved BP, insulin and oxidative stress in hypertensive coronary patients.
- Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes
PubMed ID: 12428181
CoQ10 improved BP and glycemic control in type 2 diabetes — supportive of cardiovascular health.
- Nutritional supplementation with MyoVive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction
PubMed ID: 12075268
Preoperative CoQ10‑containing supplement increased myocardial CoQ10 substantially and was associated with a significant reduction in LV end‑diastolic volume vs placebo.
- The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure
PubMed ID: 16081469
Long‑term multinutrient program including CoQ10 improved LV volumes, LVEF and quality of life in elderly heart failure patients (combined intervention but meaningful heart outcomes).
- Effect of a hydrophilic and a hydrophobic statin on cardiac salvage after ST-elevated acute myocardial infarction - a pilot study
PubMed ID: 25262434
Rosuvastatin produced better myocardial salvage and LVEF improvement after STEMI and increased CoQ10/LDL ratio vs atorvastatin (links CoQ metrics to improved post‑infarct outcomes).
- Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study
PubMed ID: 8241697
Large multicenter 1‑year RCT in CHF showed CoQ10 added to standard care reduced hospitalizations and serious HF complications — strong clinical heart outcome evidence.
- Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease
PubMed ID: 22342390
Reduced IL-6 and oxidative stress in CAD patients are cardioprotective biomarkers.
- Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting
PubMed ID: 7979670
Preop CoQ10 reduced markers of ischemia/reperfusion and ventricular arrhythmias during CABG—cardiac protection.
- Recovery of load-induced left ventricular diastolic dysfunction by coenzyme Q10: echocardiographic study
PubMed ID: 7752826
Children with load‑induced dysfunction: short‑term CoQ10 restored abnormal diastolic/systolic responses—improves cardiac function.
- Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group
PubMed ID: 9420639
Chronic heart failure: 100 mg/day produced small gains in exercise capacity and modest EF improvements.
- Serum concentration of lipoprotein(a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: discovery of a new role
PubMed ID: 10077397
Acute coronary patients: improved lipid profile and reduced oxidative stress—cardioprotective signals.
- Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension
PubMed ID: 11780680
Substantial systolic BP reduction in isolated systolic hypertension supports cardiovascular (heart) benefit.
- Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction
PubMed ID: 12841346
One-year post-MI randomized trial: fewer total cardiac events and non-fatal MI with CoQ10—strong clinical cardiac benefit.
- Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study
PubMed ID: 15188947
Improved 6‑min walk and clinical symptoms in end‑stage heart‑failure patients awaiting transplant.
- Effect of ubiquinol on electrophysiology during high-altitude acclimatization and de-acclimatization: A substudy of the Shigatse CARdiorespiratory fitness (SCARF) randomized clinical trial
PubMed ID: 38307422
Ubiquinol before altitude exposure shortened ventricular repolarization (Tpeak–Tend) and preserved maximal exercise HR, favorable electrophysiologic cardiac effects.
- Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway
PubMed ID: 38281937
Randomized MI cohort showed faster improvement in EF/FS and BNP reductions with adjunctive CoQ10 and mechanistic suppression of IL‑1β/NLRP3 in animal/cell models.
- Decreased Concentration of Fibroblast Growth Factor 23 (FGF-23) as a Result of Supplementation with Selenium and Coenzyme Q(10) in an Elderly Swedish Population: A Sub-Analysis
PubMed ID: 35159318
Selenium+CoQ10 lowered FGF‑23 (linked to worse heart/kidney outcomes) over 48 months—CV‑relevant biomarker improvement (combined).
- Coenzyme Q10 supplementation improves cholesterol efflux capacity and antiinflammatory properties of high-density lipoprotein in Chinese adults with dyslipidemia
PubMed ID: 35700592
CoQ10 improved HDL functional properties (cholesterol efflux, lower HDL inflammatory index) in dyslipidemic adults—favorable for cardiovascular health.
- Selenium and Coenzyme Q(10) Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality-Sub-Study of a Randomized Clinical Trial
PubMed ID: 36014852
Selenium+CoQ10 preserved telomere length and associated with fewer cardiovascular deaths—healthy heart/aging signal (combined).
- Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden
PubMed ID: 35381849
Selenium+CoQ10 RCT lowered inflammation/oxidative stress and linked via modeling to improved cardiac biomarkers and reduced long‑term CV mortality (combined intervention).
- Effect of selenium and Q10 on the cardiac biomarker NT-proBNP
PubMed ID: 23895165
Long-term CoQ10+selenium data showed reductions in NT-proBNP and cardiovascular mortality in prespecified subgroup—strong cardiac signal (combined).
- Dietary Supplementation with Selenium and Coenzyme Q(10) Prevents Increase in Plasma D-Dimer While Lowering Cardiovascular Mortality in an Elderly Swedish Population
PubMed ID: 33920725
Long‑term selenium+CoQ10 prevented D‑dimer rise and was associated with lower CV mortality in higher‑risk subgroups—supports cardiovascular benefit (combination).
- Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects
PubMed ID: 32741773
Perioperative ubiquinol reduced troponin/CK-MB and associated with better LVEF at 6 months — strong cardiac protection signal.
- Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial
PubMed ID: 32326664
Ubiquinol improved endothelial function (FMD) and NOx in dyslipidemic adults — vascular support for heart health.
- NT-Pro BNP Predicts Myocardial Injury Post-vascular Surgery and is Reduced with CoQ(10): A Randomized Double-Blind Trial
PubMed ID: 31629852
Preoperative CoQ10 reduced postoperative NT-proBNP at 24 h — meaningful cardiac biomarker improvement.
- Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial
PubMed ID: 30835327
Large double-blind RCT in chronic HF found major reductions in MACE and all-cause mortality and improved LVEF (strong cardiac benefit).
- Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly
PubMed ID: 29641571
Large RCT with 12‑yr follow‑up found selenium+CoQ10 reduced cardiovascular mortality substantially (strong clinical outcome albeit combined intervention).
- Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals
PubMed ID: 29454678
CoQ10 modestly lowered systolic BP and triglycerides in dyslipidemic adults—favorable cardiovascular risk changes.
- Supplementation with Selenium and Coenzyme Q10 Reduces Cardiovascular Mortality in Elderly with Low Selenium Status. A Secondary Analysis of a Randomised Clinical Trial
PubMed ID: 27367855
CV mortality reductions in low selenium elders with selenium+CoQ10 support cardiovascular vitality (combined treatment).
- Combination Therapy With Coenzyme Q10 and Trimetazidine in Patients With Acute Viral Myocarditis
PubMed ID: 27046339
In acute viral myocarditis CoQ10 (with trimetazidine) improved inflammatory/oxidative biomarkers and LVEF/troponin when combined.
- Effect of coenzyme Q10 on the incidence of atrial fibrillation in patients with heart failure
PubMed ID: 25919281
Adjunctive CoQ10 in heart failure reduced oxidative stress and markedly fewer new atrial fibrillation episodes at 12 months.
- Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial
PubMed ID: 26375288
Selenium+CoQ10 lowered CRP and sP‑selectin and associated with lower CV mortality in elders (combo).
- Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens
PubMed ID: 26624886
Large RCT of selenium+CoQ10 showed ~50% relative reduction in cardiovascular mortality and improved NT‑proBNP/EF — strong cardiac outcome (combo product).
- Less increase of copeptin and MR-proADM due to intervention with selenium and coenzyme Q10 combined: Results from a 4-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
PubMed ID: 26662217
Selenium+CoQ10 resulted in smaller rises in copeptin and MR‑proADM and lower CV death over 4 years (combo therapy).
- The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial
PubMed ID: 25282031
Q‑SYMBIO: large randomized trial (n=420) showing significant reductions in major adverse CV events and both CV & all‑cause mortality with CoQ10 300 mg/day.
- Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial
PubMed ID: 24192015
In CAD patients on statins, CoQ10 raised antioxidant enzymes and lowered inflammatory markers relevant to cardiac health.
Antioxidant (55)
- Clinical and biochemical effects of coenzyme Q(10), vitamin E, and selenium supplementation to psoriasis patients
PubMed ID: 19041224
CoQ10 with vitamin E and selenium in severe psoriasis normalized oxidative stress markers faster and improved clinical severity—strong biomarker signal though multi‑ingredient.
- The clinical outcome of Montelukast versus co-enzyme Q10 in adult patients with sepsis: A randomized controlled clinical trial
PubMed ID: 40845766
CoQ10 in sepsis ICU reduced oxidative markers and improved outcomes, supporting antioxidant protection in critical illness.
- Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study
PubMed ID: 39999976
High‑dose CoQ10 after ischemic stroke produced significant reductions in MDA and IL‑6 and increased SOD and BDNF—strong antioxidant biomarker evidence.
- Discovering the Potential Value of Coenzyme Q10 as an Adjuvant Treatment in Patients With Depression
PubMed ID: 38684047
Adjunctive CoQ10 decreased nitric oxide and increased total thiols, indicating improved redox status in depressed patients.
- Selenium and coenzyme Q(10) improve the systemic redox status while reducing cardiovascular mortality in elderly population-based individuals
PubMed ID: 37179031
Selenium+CoQ10 increased serum free‑thiols (lower oxidative stress) over 4 years—robust systemic antioxidant marker change (combination).
- Effects of an Intervention with Selenium and Coenzyme Q(10) on Five Selected Age-Related Biomarkers in Elderly Swedes Low in Selenium: Results That Point to an Anti-Ageing Effect-A Sub-Analysis of a Previous Prospective Double-Blind Placebo-Controlled Randomised Clinical Trial
PubMed ID: 37443807
Selenium+CoQ10 RCT shifted multiple oxidative‑stress/inflammatory biomarkers favorably across 48 months (combined intervention).
- Effect of coenzyme Q10 supplementation on oxidative stress and clinical outcomes in patients with low levels of coenzyme Q10 admitted to the intensive care unit
PubMed ID: 34290862
CoQ10 decreased MDA (oxidative stress marker) markedly in ventilated trauma patients—strong antioxidant biomarker effect with clinical benefit.
- A randomized controlled trial on the coloprotective effect of coenzyme Q10 on immune-inflammatory cytokines, oxidative status, antimicrobial peptides, and microRNA-146a expression in patients with mild-to-moderate ulcerative colitis
PubMed ID: 33620550
Ulcerative colitis RCT: CoQ10 lowered NF‑κB and IL‑17 and improved QoL, consistent with antioxidant/anti‑inflammatory action.
- Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise
PubMed ID: 32041223
Ubiquinol modulated inflammatory signaling and preserved blood measures after exercise (antioxidant/anti-inflammatory effects).
- The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients
PubMed ID: 32544011
CoQ10 lowered inflammatory markers (TNF-α, IL-6, hs-CRP) consistent with antioxidant/anti-inflammatory action.
- Coenzyme Q10 improves the survival and reduces inflammatory markers in septic patients
PubMed ID: 32115970
Sepsis RCT lowered MDA (lipid peroxidation) and inflammatory markers with CoQ10 — evidence of oxidative stress reduction.
- Coenzyme Q(10) supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders
PubMed ID: 29684771
Children with autism showed decreased MDA and increased CoQ10 serum levels—antioxidant biomarker improvements.
- Effect of Coenzyme Q(10) on Insulin Resistance in Korean Patients with Prediabetes: A Pilot Single-Center, Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 30151373
Prediabetes RCT reduced free oxygen radicals (FORT) and increased blood CoQ10.
- The effect of short-term coenzyme Q10 supplementation and pre-cooling strategy on cardiac damage markers in elite swimmers
PubMed ID: 29498347
Elite swimmer study blunted exercise-induced oxidative stress and cardiac injury markers.
- Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial
PubMed ID: 29936921
Ubiquinol increased antioxidant enzyme activity and reduced HbA1c in T2DM—strong biochemical antioxidant signal.
- Effects of coenzyme Q10 supplementation on serum values of adiponectin, leptin, 8-isoprostane and malondialdehyde in women with type 2 diabetes
PubMed ID: 29933718
T2DM trial raised adiponectin, lowered leptin and reduced oxidative markers (MDA, 8-isoprostane).
- The Effects of Coenzyme Q10 Supplementation on Glucose Metabolism, Lipid Profiles, Inflammation, and Oxidative Stress in Patients With Diabetic Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 29111905
CoQ10 lowered MDA and AGEs and improved HbA1c/HOMA in diabetic nephropathy, showing antioxidant and metabolic benefits.
- Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial
PubMed ID: 27193497
Large RCT showed ubiquinol reduced multiple oxidative stress markers (isoprostanes, 8‑OHdG, oxidized LDL) and increased antioxidant measures around strenuous exercise.
- Effect of Coenzyme Q(10) on Biomarkers of Oxidative Stress and Cardiac Function in Hemodialysis Patients: The CoQ(10) Biomarker Trial
PubMed ID: 27927588
Dose‑dependent reduction in F2‑isoprostanes in hemodialysis patients demonstrates a clear antioxidant biochemical effect.
- Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial
PubMed ID: 27716246
HCC post‑op RCT: substantial increases in antioxidant enzymes (SOD, CAT, GPx) and decreased MDA.
- Circulating levels of reactive oxygen species in patients with nonproliferative diabetic retinopathy and the influence of antioxidant supplementation: 6-month follow-up
PubMed ID: 25686055
Multi‑antioxidant supplement including CoQ10 lowered ROS in diabetic retinopathy, but cannot isolate CoQ10 effect.
- The effect of ubiquinone and combined antioxidant therapy on oxidative stress markers in non-proliferative diabetic retinopathy: A phase IIa, randomized, double-blind, and placebo-controlled study
PubMed ID: 26321469
NPDR trial showed robust reductions in lipid peroxidation and increased TAC with CoQ10/antioxidant therapy.
- The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome
PubMed ID: 26385228
MetS RCT improved TAC and reduced insulin resistance — antioxidant marker improvement reported.
- Effect of coenzyme Q10 on the incidence of atrial fibrillation in patients with heart failure
PubMed ID: 25919281
Heart failure RCT: reduced MDA and fewer AF episodes—antioxidant and clinical cardiac signal.
- Effect of coenzyme Q10 on glycaemic control, oxidative stress and adiponectin in type 2 diabetes
PubMed ID: 25976576
In T2DM trial CoQ10 reduced MDA vs placebo (oxidative marker).
- Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial
PubMed ID: 26342738
RA RCT showed reduced MDA (lipid peroxidation) and attenuation of TNF‑α, strong antioxidant biomarker effect.
- The Effect of Coenzyme Q10 Supplementation on Pro-Inflammatory Factors and Adiponectin in Mildly Hypertensive Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 26780394
Decreases in IL‑6 and hs‑CRP and increased adiponectin indicate lowered systemic oxidative/inflammatory burden.
- Effective photoprotection of human skin against infrared A radiation by topically applied antioxidants: results from a vehicle controlled, double-blind, randomized study
PubMed ID: 25349107
Topical antioxidant cocktail containing ubiquinone reduced IRA‑induced MMP‑1 (skin oxidative damage marker).
- Effect of Coenzyme Q10 on Oxidative Stress, Glycemic Control and Inflammation in Diabetic Neuropathy: A Double Blind Randomized Clinical Trial
PubMed ID: 26255546
Diabetic neuropathy RCT: increased TAC and reduced CRP—improved antioxidant/inflammatory profile.
- Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis
PubMed ID: 23659338
RRMS RCT: increased SOD, decreased MDA and improved TAC—direct antioxidant biomarker effects.
- Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial
PubMed ID: 23289958
Seminal CoQ10 RCT: increased antioxidant enzyme activity and lowered 8‑isoprostane (oxidative stress marker).
- Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial
PubMed ID: 24192015
300 mg/day CoQ10 raised antioxidant enzyme activities (SOD, CAT, GPx) and lowered inflammatory markers in CAD patients.
- Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease
PubMed ID: 22342390
CoQ10 reduced IL-6 and improved oxidative stress markers (MDA, SOD) in CAD trial, supporting antioxidant activity.
- Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial
PubMed ID: 21399391
CoQ10 supplementation in men with poor semen quality improved seminal total antioxidant capacity and reduced TBARS — direct antioxidant effect in semen.
- Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial
PubMed ID: 21388622
CoQ10 improved mitochondrial LP ratio and correlated with endothelial improvements — supports antioxidant/mitochondrial protective effects.
- Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease
PubMed ID: 21996047
Randomized CAD trial: higher‑dose CoQ10 lowered MDA and increased CAT/SOD activity — clear biochemical evidence of antioxidant effects.
- Water-soluble coenzyme Q10 formulation (Q-TER(®)) in the treatment of presbycusis
PubMed ID: 20443731
Q‑TER improved hearing thresholds versus vitamin E; likely mediated by antioxidant/mitochondrial effects in cochlea.
- Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study
PubMed ID: 17644511
CAD trial increased endothelium‑bound ecSOD activity and improved endothelial antioxidant function.
- Effect on absorption and oxidative stress of different oral Coenzyme Q10 dosages and intake strategy in healthy men
PubMed ID: 16873950
Dose/formulation study showed plasma CoQ10 increases and a significant reduction in MDA (oxidative stress marker).
- Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue
PubMed ID: 15632821
Myocardial mitochondrial malondialdehyde decreased with CoQ10, indicating reduced oxidative damage.
- Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction
PubMed ID: 12841346
Post-MI one-year trial: reduced lipid peroxidation (MDA) and other oxidative-stress markers with Q10 treatment.
- Antioxidative efficacy of parallel and combined supplementation with coenzyme Q10 and d-alpha-tocopherol in mildly hypercholesterolemic subjects: a randomized placebo-controlled clinical study
PubMed ID: 10993487
Q10 raised plasma levels and altered redox markers though it did not enhance vitamin E's LDL antioxidant effect in this study.
- Serum concentration of lipoprotein(a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: discovery of a new role
PubMed ID: 10077397
Acute coronary patients: significant reduction in oxidative stress markers and improved lipoprotein profile with Q10.
- Effect of combined coenzyme Q10 and d-alpha-tocopheryl acetate supplementation on exercise-induced lipid peroxidation and muscular damage: a placebo-controlled double-blind study in marathon runners
PubMed ID: 9733025
Marathoners given Q10+vitE had reduced lipoprotein susceptibility to oxidation and large plasma Q10 increases.
- Protection by coenzyme Q10 of tissue reperfusion injury during abdominal aortic cross-clamping
PubMed ID: 8698756
Randomized study: CoQ10 pre‑treatment lowered MDA, conjugated dienes, CK and LDH after reperfusion—strong antioxidant/protective signal.
- Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting
PubMed ID: 7979670
Preop CoQ10 reduced oxidative stress markers during CABG—direct antioxidant marker improvements.
- Coenzyme Q10 and antioxidants in acute myocardial infarction
PubMed ID: 7752825
Antioxidant therapy that included CoQ10 in recent MI reduced QT prolongation and was associated with fewer cardiac deaths (clinical antioxidant outcome signal).
- A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins
PubMed ID: 25732262
Supplement (including CoQ10) decreased carbonylated proteins and improved skin/serum markers of oxidative damage — antioxidant biomarker improvement (multi‑ingredient).
- Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study
PubMed ID: 17824295
Ubiquinol + L‑carnitine lowered pro‑inflammatory cytokines and increased serum CoQ10, consistent with antioxidant/anti‑inflammatory actions.
- Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis. A Randomized, Controlled, Multicenter Clinical Trial
PubMed ID: 29688760
Antioxidant‑enriched multivitamin containing CoQ10 raised systemic CoQ and reduced inflammatory markers (MPO, calprotectin).
- Effect of Short-term Coenzyme Q10 Supplementation and Precooling on Serum Endogenous Antioxidant Enzymes of Elite Swimmers
PubMed ID: 28486329
In elite swimmers CoQ10 prevented exercise‑associated perturbations in antioxidant enzymes (SOD, CAT, GPx).
- Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
PubMed ID: 26156412
CoQ10 (100 mg/day) in NAFLD lowered liver enzymes and hs‑CRP (inflammatory marker), consistent with reduced oxidative/inflammatory stress.
- A pilot double-blind, placebo-controlled, randomized clinical trial of MitoQ in the treatment of septic shock: evaluating its effects on clinical outcomes and oxidative stress biomarker
PubMed ID: 40820063
MitoQ improved GPx/CAT/SOD and reduced MDA in septic shock patients—clear antioxidant biomarker improvements.
- Complementary therapy in diabetic patients with chronic complications: a pilot study
PubMed ID: 20586147
Pilot randomized study in diabetics found antioxidant supplementation including CoQ10 reduced plasma lipid peroxides—direct biomarker evidence of antioxidant effect (small, combined intervention).
- Effect of oral CoQ(10) supplementation along with precooling strategy on cellular response to oxidative stress in elite swimmers
PubMed ID: 30058646
Two‑week CoQ10 in elite swimmers attenuated exercise‑related oxidative stress markers—experimental evidence for antioxidant protection during stress.
Energy & Fatigue (42)
- Coenzyme Q10 as a potential add-on treatment for patients suffering from painful diabetic neuropathy: results of a placebo-controlled randomized trial
PubMed ID: 36273066
CoQ10 as add‑on to pregabalin produced greater pain relief and better sleep‑related pain outcomes in painful diabetic neuropathy — may reduce fatigue via improved sleep/pain control.
- Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction
PubMed ID: 18487480
Direct CoQ10 supplementation in diabetics raised plasma/cellular CoQ10 (biochemical evidence) though functional diastolic indices were unchanged.
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
Ubiquinol (600 mg/day) in HFpEF increased ATP and improved lactate/ATP ratio alongside clinical benefit — clear bioenergetic effect.
- Effect of gummy candy containing ubiquinol on secretion of saliva: A randomized, double-blind, placebo-controlled parallel-group comparative study and an in vitro study
PubMed ID: 30943227
Ubiquinol gummies (100 mg) increased saliva flow and improved reported fatigue symptoms vs placebo in adults with mild dry‑mouth complaints.
- Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?
PubMed ID: 25386668
Randomized CFS trial (CoQ10+NADH) increased NAD+/NADH, ATP, citrate synthase and reduced lipoperoxides — strong direct cellular‑energy evidence.
- A randomized trial of coenzyme Q10 in mitochondrial disorders
PubMed ID: 20886510
Direct CoQ10 monotherapy in mitochondrial disease reduced post‑exercise lactate and produced a measurable VO2 increase—strongest direct human evidence for cellular bioenergetic benefit.
- Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise
PubMed ID: 32041223
Ubiquinol preserved RBC/hemoglobin/hematocrit after strenuous exercise, which may reduce post-exertional fatigue.
- Effect of coenzyme Q10 supplementation on oxidative stress and clinical outcomes in patients with low levels of coenzyme Q10 admitted to the intensive care unit
PubMed ID: 34290862
CoQ10 in ventilated trauma patients shortened ventilation and hospital/ICU stays—clinically meaningful reductions in illness‑related fatigue/recovery time.
- Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway
PubMed ID: 38281937
Post‑MI trial showed faster recovery of EF and BNP reductions and mechanistic macrophage/mitochondrial effects, implying improved cardiac cellular energetics.
- Effect of coenzyme Q10 on post-extraction tissue healing in wisdom tooth Surgery: double-blind randomized clinical trial
PubMed ID: 40616597
Post‑extraction CoQ10 accelerated healing and improved physical recovery scores, which included less pain and faster functional recovery (reduced fatigue).
- Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study
PubMed ID: 39999976
High‑dose CoQ10 in stroke increased antioxidant enzymes and BDNF and reduced oxidative stress—consistent with support for cellular bioenergetics.
- Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise
PubMed ID: 32797125
Ubiquinol increased exercise-related PGC-1α and energy-metabolism markers → supports cellular energy pathways.
- Efficacy and safety of an amino acid jelly containing coenzyme Q10 and L-carnitine in controlling fatigue in breast cancer patients receiving chemotherapy: a multi-institutional, randomized, exploratory trial (JORTC-CAM01)
PubMed ID: 26105516
Randomized exploratory trial: CoQ10 + L‑carnitine jelly reduced chemotherapy‑related fatigue vs usual care over 21 days (clinically relevant result for fatigue).
- Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial
PubMed ID: 30835327
CHF trial improved LVEF and clinical outcomes, compatible with better myocardial cellular energy handling.
- Coenzyme q10 liquid supplementation in dyslipidemic subjects with statin-related clinical symptoms: a double-blind, randomized, placebo-controlled study
PubMed ID: 31695332
Statin-intolerant patients had meaningful reductions in myalgia and CPK—translates to less fatigue/pain.
- Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome
PubMed ID: 27125909
Randomized double‑blind trial in CFS showed ubiquinol improved fatigue‑related symptoms and related functions.
- The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study
PubMed ID: 26207797
Ubiquinone improved erythrocyte and platelet mitochondrial membrane fluidity and reduced F0F1‑ATPase hydrolysis in diabetic retinopathy patients (clear mitochondrial/energetic effects).
- Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome - A randomized, controlled, double-blind trial
PubMed ID: 26212172
CoQ10+NADH reduced subjective fatigue and physiologic exercise HR in CFS patients (combined product).
- Coenzyme Q10 benefits symptoms in Gulf War veterans: results of a randomized double-blind study
PubMed ID: 25149705
Gulf War illness RCT: 100 mg/day improved symptoms and physical function, with fatigue improvements especially in men.
- Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study
PubMed ID: 25375075
Mild–moderate statin‑symptoms RCT: CoQ10 reduced pain and interference; fatigue reductions plausible secondary effect.
- The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial
PubMed ID: 25282031
Q‑SYMBIO clinical benefits in CHF are consistent with improved mitochondrial/energetic function at organ level.
- Coenzyme Q(10) and selenium in statin-associated myopathy treatment
PubMed ID: 23458201
Statin‑associated myopathy pilot: large reductions in reported tiredness alongside CoQ10 rises (pilot, co‑supplementation caveat).
- The effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study
PubMed ID: 22595020
Diabetic neuropathy trial showed symptomatic and electrophysiologic improvements with reduced lipid peroxidation and plausible mitochondrial benefit.
- Assessment of neurological efficacy of idebenone in pediatric patients with Friedreich's ataxia: data from a 6-month controlled study followed by a 12-month open-label extension study
PubMed ID: 21779958
High-dose idebenone in Friedreich ataxia showed dose-dependent neurological improvement, consistent with mitochondrial/energy effects.
- Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial
PubMed ID: 21388622
RCT in ischemic LV dysfunction: CoQ10 improved mitochondrial function markers and correlated with FMD improvement — strong mechanistic support for cellular energy benefits.
- Coenzyme Q10 improves diastolic function in children with idiopathic dilated cardiomyopathy
PubMed ID: 19703336
In children with dilated cardiomyopathy CoQ10 improved diastolic function—consistent with improved myocardial cellular energetics in clinical disease.
- Coenzyme Q10 and vitamin E deficiency in Friedreich's ataxia: predictor of efficacy of vitamin E and coenzyme Q10 therapy
PubMed ID: 19049556
FRDA patients with low CoQ10 showed biochemical restoration and clinical improvement in a subset—suggests CoQ10 can support cellular energetic deficits in mitochondrial disease.
- Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study
PubMed ID: 17681347
CoQ10 restored plasma levels reduced by atorvastatin, indicating replenishment of a mitochondrial cofactor though functional benefit was not shown.
- Coenzyme Q10 in patients undergoing CABG: Effect of statins and nutritional supplementation
PubMed ID: 17368873
Short-term CoQ10 increased plasma and cardiac tissue CoQ10 concentrations—directly relevant to myocardial cellular energy stores.
- Safety assessment of PureSorb-Q40 in healthy subjects and serum coenzyme Q10 level in excessive dosing
PubMed ID: 17874823
High-dose PureSorb-Q40 markedly raised serum CoQ10 in healthy volunteers; increased circulating CoQ10 supports mitochondrial electron-transport substrate availability (biomarker-level evidence).
- Effect of coenzyme q10 on myopathic symptoms in patients treated with statins
PubMed ID: 17493470
Statin-associated muscle pain study reported substantial reductions in pain and interference, likely reducing fatigue related to myalgia.
- Comparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilizate (Solu Q10)
PubMed ID: 17162333
Solu Q10 formulation increased intracellular CoQ10 — mechanistically supportive for cellular bioenergetics.
- Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue
PubMed ID: 15632821
Strong biochemical evidence: raised myocardial/mitochondrial CoQ10, improved ADP/O ratio and better contractile recovery after hypoxia.
- Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study
PubMed ID: 15188947
Trial reported decreased fatigue in heart‑failure patients on CoQ10.
- Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction
PubMed ID: 12841346
Post-MI trial showed improved oxidative biomarkers and fewer events; supports improved cellular function/energy in cardiac tissue.
- Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors
PubMed ID: 9266515
Statins significantly lowered serum CoQ10—supports CoQ10's role in cellular energetics and rationale for replacement.
- Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group
PubMed ID: 9420639
CHF patients had small gains in exercise capacity and QoL that correspond with reduced fatigue.
- Recovery of load-induced left ventricular diastolic dysfunction by coenzyme Q10: echocardiographic study
PubMed ID: 7752826
Restoration of abnormal diastolic/systolic responses to load after CoQ10 suggests improved cellular energetics.
- Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study
PubMed ID: 8241697
Large CHF trial with clinical benefits consistent with improved cardiac cellular function and energy economy.
- The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial
PubMed ID: 30612463
CoQ10 + L‑carnitine lowered lactate and improved migraine clinical measures, indicating improved cellular metabolic handling.
- Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study
PubMed ID: 17824295
Ubiquinol plus L‑carnitine produced big rises in serum CoQ10 and improved 6‑minute walk and decreased inflammatory markers — direct mitochondrial/energy support evidence (although combined treatment).
- Nutritional supplementation with MyoVive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction
PubMed ID: 12075268
Pre‑op supplement including CoQ10 raised myocardial CoQ10 substantially and associated with favorable LVEDV change — supports myocardial cellular energy stores.
Healthy aging (28)
- Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue
PubMed ID: 15632821
Preoperative trial increased myocardial/mitochondrial CoQ10 and mitochondrial efficiency — supports cellular mechanisms linked to healthy aging.
- A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins
PubMed ID: 25732262
4‑week randomized supplement (incl. CoQ10) improved photoaging scores, skin hydration and reduced carbonylated proteins — markers of aging (multi‑ingredient product).
- Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study
PubMed ID: 8241697
Large 1‑year CHF RCT showing clinical benefits (fewer hospitalizations/complications) that are relevant to healthy aging/clinical durability.
- Idebenone, a new drug in the treatment of cognitive impairment in patients with dementia of the Alzheimer type
PubMed ID: 7988944
Idebenone improved cognition in Alzheimer-type dementia—relevant to neurodegenerative aspects of aging (analogue).
- A controlled study of 2 doses of idebenone in the treatment of Alzheimer's disease
PubMed ID: 9267856
6‑month idebenone cognitive/global improvements—indirect support for aging-related cognitive preservation.
- Sustained efficacy and safety of idebenone in the treatment of Alzheimer's disease: update on a 2-year double-blind multicentre study
PubMed ID: 9850939
Two‑year idebenone slowed Alzheimer’s progression—suggests potential aging-related neuroprotection (analogue).
- Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline
PubMed ID: 12374491
Dose-dependent slowing of Parkinson functional decline with high-dose Q10 suggests potential neuroprotective/aging benefits.
- Low plasma coenzyme Q(10) levels and breast cancer risk in Chinese women
PubMed ID: 21467235
Large prospective study: low prediagnostic plasma CoQ10 associated with higher future breast cancer risk — epidemiologic evidence linking CoQ10 status to long‑term health.
- Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
PubMed ID: 22626835
Large 5-year RCT (selenium+CoQ10) reduced cardiovascular mortality and NT-proBNP in elderly — strong clinically relevant aging benefit (combined supplement).
- Effect of selenium and Q10 on the cardiac biomarker NT-proBNP
PubMed ID: 23895165
Long-term trial showed reduced NT-proBNP and cardiovascular deaths in elderly (subgroup), supporting healthy aging (combined with selenium).
- The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial
PubMed ID: 25282031
Long‑term CHF trial showed reduced mortality and major events—supports healthier longer‑term outcomes in a disease population.
- Less increase of copeptin and MR-proADM due to intervention with selenium and coenzyme Q10 combined: Results from a 4-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
PubMed ID: 26662217
Selenium+CoQ10 reduced rise in copeptin/MR‑proADM and cardiovascular deaths over 4 years (combo intervention).
- Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens
PubMed ID: 26624886
Large 4‑yr selenium+CoQ10 trial showed ~50% relative reduction in CV death and preserved cardiac markers — strong aging/long‑term health signal (combo product).
- Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial
PubMed ID: 26375288
Long supplementation with selenium+CoQ10 reduced CRP and sP‑selectin and associated with lower CV mortality.
- Improved Health-Related Quality of Life, and More Days out of Hospital with Supplementation with Selenium and Coenzyme Q10 Combined. Results from a Double Blind, Placebo-Controlled Prospective Study
PubMed ID: 26482687
Combined selenium+CoQ10 associated with more days alive outside hospital and less decline in physical QoL in older adults.
- Supplementation with Selenium and Coenzyme Q10 Reduces Cardiovascular Mortality in Elderly with Low Selenium Status. A Secondary Analysis of a Randomised Clinical Trial
PubMed ID: 27367855
Benefit concentrated in low selenium subgroup for CV mortality with selenium+CoQ10 — relevant to healthy aging in nutrient‑deficient elders.
- Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
PubMed ID: 28448590
Four years of selenium+CoQ10 produced broad circulating microRNA changes in elderly men consistent with anti‑aging biology (combined).
- Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly
PubMed ID: 29641571
Large RCT with 12‑yr follow‑up showed selenium+CoQ10 reduced cardiovascular mortality—major clinically relevant healthy‑aging signal (combined intervention).
- Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial
PubMed ID: 30835327
Large CHF trial reduced mortality and improved LVEF over 2 years—supports longevity/age-related cardiac outcomes.
- Selenium and Coenzyme Q10 Supplementation Improves Renal Function in Elderly Deficient in Selenium: Observational Results and Results from a Subgroup Analysis of a Prospective Randomised Double-Blind Placebo-Controlled Trial
PubMed ID: 33317156
4‑yr Se+CoQ10 trial produced clinically meaningful improvements in renal markers in elderly (combined supplement).
- Dietary Supplementation with Selenium and Coenzyme Q(10) Prevents Increase in Plasma D-Dimer While Lowering Cardiovascular Mortality in an Elderly Swedish Population
PubMed ID: 33920725
Elderly trial: selenium+CoQ10 prevented D‑dimer rise and had subgroup CV mortality benefit—supports aging/cardiovascular protection but intervention combined.
- Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden
PubMed ID: 35381849
Longitudinal RCT (selenium+CoQ10) lowered inflammation/oxidative stress biomarkers and linked to lower CV mortality via modeling (combined intervention).
- Selenium and Coenzyme Q(10) Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality-Sub-Study of a Randomized Clinical Trial
PubMed ID: 36014852
Selenium+CoQ10 RCT preserved leukocyte telomere length over 4 years and associated with fewer CV deaths—strong aging biomarker signal (combined product).
- Decreased Concentration of Fibroblast Growth Factor 23 (FGF-23) as a Result of Supplementation with Selenium and Coenzyme Q(10) in an Elderly Swedish Population: A Sub-Analysis
PubMed ID: 35159318
Selenium+CoQ10 lowered FGF‑23 over 4 years, a marker linked to worse outcomes—supports healthy‑aging pathway (combined).
- Effects of an Intervention with Selenium and Coenzyme Q(10) on Five Selected Age-Related Biomarkers in Elderly Swedes Low in Selenium: Results That Point to an Anti-Ageing Effect-A Sub-Analysis of a Previous Prospective Double-Blind Placebo-Controlled Randomised Clinical Trial
PubMed ID: 37443807
Large 48‑month selenium+CoQ10 trial altered several age‑related biomarkers favorably; effects reflect anti‑aging biomarker shifts (combination therapy).
- Selenium and coenzyme Q(10) improve the systemic redox status while reducing cardiovascular mortality in elderly population-based individuals
PubMed ID: 37179031
Selenium+CoQ10 increased serum free thiols (reduced oxidative stress) over 4 years—relevant to biological aging (combined supplement).
- Selenoprotein P increases upon selenium and coenzyme Q(10) supplementation and is associated with telomere length, quality of life and reduced inflammation and mortality
PubMed ID: 38960007
Long (4‑yr) selenium+CoQ10 supplementation increased SELENOP and associated with longer telomeres, better QoL and reduced mortality in older adults (combined product).
- Supplementation with selenium and coenzyme Q(10) in an elderly Swedish population low in selenium - positive effects on thyroid hormones, cardiovascular mortality, and quality of life
PubMed ID: 38714999
Same long trial (selenium+CoQ10) showed favorable shifts in thyroid hormones and lower CV mortality—relevant to healthy aging though not CoQ10‑only.
Cell health (27)
- Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors
PubMed ID: 7752830
Oral CoQ10 prevented statin‑related falls in plasma and platelet CoQ10 concentrations — preserves cellular ubiquinone important for cellular vitality.
- Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction
PubMed ID: 12841346
Post-MI improvements in oxidative markers and clinical events indicate better cellular/mitochondrial status in cardiac tissue.
- Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study
PubMed ID: 17824295
Large rises in serum CoQ10 (ubiquinol) and reductions in inflammatory cytokines with functional improvement indicate robust support for cellular vitality (combined therapy).
- Nutritional supplementation with MyoVive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction
PubMed ID: 12075268
Marked myocardial CoQ10 increases in treated patients vs placebo indicate direct augmentation of tissue CoQ (cellular vitality signal).
- Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction
PubMed ID: 18487480
Direct CoQ10 supplementation increased plasma and cellular CoQ levels in diabetics (strong biochemical evidence for restoring cellular CoQ pools).
- Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis. A Randomized, Controlled, Multicenter Clinical Trial
PubMed ID: 29688760
Supplement raised systemic CoQ10 and other antioxidants while lowering inflammation markers — supports cellular maintenance.
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
Ubiquinol increased ATP and improved lactate/ATP ratio and cardiac biomarkers, indicating improved cellular bioenergetics.
- Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?
PubMed ID: 25386668
Demonstrated increases in ATP, NAD+/NADH and citrate synthase — strong evidence for improved cellular function/vitality with CoQ10+NADH.
- Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study
PubMed ID: 39999976
Post‑stroke increases in SOD/BDNF and reductions in oxidative biomarkers support improved cellular resilience and vitality.
- Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway
PubMed ID: 38281937
Improvements in cardiac function and reduced inflammasome signaling point to better cellular health in the myocardium.
- Impact of coenzyme Q10 as an adjuvant therapy to letrozole on spermiogram results and sex hormone levels in Iraqi men with infertility; randomized open label comparative study
PubMed ID: 38957201
Adding CoQ10 to letrozole improved sperm concentration, total count and morphology—direct evidence of improved cellular vitality in sperm.
- Selenium and Coenzyme Q(10) Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality-Sub-Study of a Randomized Clinical Trial
PubMed ID: 36014852
Preservation of leukocyte telomere length with selenium+CoQ10 indicates cellular longevity/vitality (combined intervention).
- Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise
PubMed ID: 32041223
Ubiquinol's preservation of hematologic parameters and modulation of exercise biomarkers suggests cellular preservation.
- Impact of Coenzyme Q10 and Selenium on Seminal Fluid Parameters and Antioxidant Status in Men with Idiopathic Infertility
PubMed ID: 32572802
CoQ10 improved sperm concentration, motility and antioxidant status—strong indication of cellular/mitochondrial vitality.
- The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study
PubMed ID: 26207797
Clear improvements in membrane fluidity and mitochondrial enzyme activity in diabetic retinopathy indicate direct cellular vitality benefits.
- Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial
PubMed ID: 27716246
Increased antioxidant enzymes and decreased MDA after CoQ10 indicate enhanced cellular antioxidant defenses in HCC patients.
- Combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome
PubMed ID: 24813752
PCOS RCT: adding CoQ10 markedly increased ovulation and pregnancy rates and improved endometrial thickness—cellular/reproductive vitality.
- Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial
PubMed ID: 23289958
Seminal plasma CoQ10 increased, antioxidant enzymes rose and sperm parameters improved—direct cellular vitality evidence.
- Effect of selenium and Q10 on the cardiac biomarker NT-proBNP
PubMed ID: 23895165
Reductions in NT-proBNP and cardiovascular deaths in older subjects suggest improved organ/cellular function (combined intervention).
- The effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study
PubMed ID: 22595020
Improvements in neuropathy symptoms and electrophysiology with reduced oxidative damage support neuronal cellular vitality.
- Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study
PubMed ID: 22704112
Ubiquinol improved sperm parameters and reproductive hormones, reflecting improved cellular vitality in reproductive cells.
- Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
PubMed ID: 22626835
Long-term biomarker and outcome improvements (combined with selenium) imply preserved organ/cellular function.
- Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial
PubMed ID: 21388622
Improvement in mitochondrial LP ratio and FMD indicates restoration of mitochondrial and endothelial cell health.
- Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men
PubMed ID: 19447425
Large RCT in idiopathic male infertility showed increased sperm density, motility and acrosome reaction with 300 mg/day CoQ10—strong cellular-vitality outcome for gametes.
- Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial
PubMed ID: 18395716
Oral CoQ10 increased seminal and sperm intracellular CoQ10 and improved sperm motility—direct evidence of improved cellular function/vitality in sperm.
- Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue
PubMed ID: 15632821
Direct increases in mitochondrial CoQ10, improved ADP/O and reduced malondialdehyde indicate improved cellular health/vitality.
- Coenzyme Q10 combined with mild hypothermia after cardiac arrest: a preliminary study
PubMed ID: 15520321
Lower S100 (brain injury marker) and better neurologic outcome post‑arrest suggest protection of cellular/neuronal viability.
Metabolism (27)
- Addition of omega-3 fatty acid and coenzyme Q10 to statin therapy in patients with combined dyslipidemia
PubMed ID: 28541926
Adding CoQ10 (with omega‑3) to statin therapy improved lipids and lowered hsCRP; metabolic improvements observed though combined therapy.
- The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome
PubMed ID: 28949260
PCOS CoQ10 downregulated LDLR/OLR1 and upregulated PPAR‑γ expression—molecular evidence for metabolic benefit.
- Clinical trial of the effects of coenzyme Q10 supplementation on glycemic control and markers of lipid profiles in diabetic hemodialysis patients
PubMed ID: 30251010
Diabetic hemodialysis RCT showed clear improvements in insulin, HOMA-IR and QUICKI (direct metabolic benefit).
- Effects of coenzyme Q10 supplementation on serum values of adiponectin, leptin, 8-isoprostane and malondialdehyde in women with type 2 diabetes
PubMed ID: 29933718
T2DM RCT increased adiponectin, decreased leptin and oxidative markers—meaningful metabolic improvements.
- Effects of Coenzyme Q10 Supplementation on Serum Values of Gamma-glutamyl transferase, Pseudocholinesterase, Bilirubin, Ferritin, and High-Sensitivity C-Reactive Protein in Women with Type 2 Diabetes
PubMed ID: 29365333
T2DM RCT decreased HOMA-IR and improved lipid profile and ferritin—strong metabolic support.
- Independent and Additive Effects of Coenzyme Q10 and Vitamin E on Cardiometabolic Outcomes and Visceral Adiposity in Women With Polycystic Ovary Syndrome
PubMed ID: 31349945
PCOS RCT showed significant triglyceride reductions and modest LDL/HDL improvements (CoQ10 ± vitamin E).
- Efficacy of food supplement to improve metabolic syndrome parameters in patients affected by moderate to severe psoriasis during anti-TNFα treatment
PubMed ID: 24442048
Psoriasis patients on etanercept receiving a multinutrient (including CoQ10) had improved HDL and lower triglycerides—supports metabolic benefit though CoQ10 not isolated.
- Reduction in asymmetric dimethylarginine plasma levels by coenzyme Q10 supplementation in patients with type 2 diabetes mellitus
PubMed ID: 26140473
CoQ10 (200 mg/day) in T2D improved HbA1c and LDL modestly and improved endothelial risk markers, indicating beneficial effects on metabolic control.
- Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
PubMed ID: 26156412
Randomized double‑blind RCT: CoQ10 (100 mg/day) for 12 weeks in NAFLD significantly lowered AST, GGT and hs‑CRP—direct metabolic/liver benefit.
- Usefulness of Nutraceuticals (Armolipid Plus) Versus Ezetimibe and Combination in Statin-Intolerant Patients With Dyslipidemia With Coronary Heart Disease
PubMed ID: 26611120
Nutraceutical mix including CoQ10 improved LDL and total cholesterol and helped statin‑intolerant patients reach lipid goals—supports metabolic/lipid benefits of combined supplementation.
- Comparison of Low-Dose Statin Versus Low-Dose Statin + Armolipid Plus in High-Intensity Statin-Intolerant Patients With a Previous Coronary Event and Percutaneous Coronary Intervention (ADHERENCE Trial)
PubMed ID: 28781026
Adding a nutraceutical (including CoQ10) to low‑dose statin produced larger LDL/total cholesterol reductions in statin‑intolerant patients (combination effect).
- Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease
PubMed ID: 10204818
CoQ10 reduced fasting/2‑hour insulin and glucose and oxidative stress markers in hypertensive CAD patients.
- Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes
PubMed ID: 12428181
CoQ10 (200 mg/day) in type 2 diabetes modestly lowered HbA1c (−0.37%) and blood pressure, demonstrating metabolic benefit.
- Effects of a dietary supplement on cholesterol in subjects with moderate hypercholesterolemia
PubMed ID: 23868627
Combined dietary supplement including CoQ10 improved cholesterol measures (TC, LDL, HDL) versus diet/exercise alone (multi‑ingredient product shows metabolic benefit).
- The effect of coenzyme Q10 supplementation on metabolic status of type 2 diabetic patients
PubMed ID: 23831913
200 mg/day CoQ10 modestly improved HbA1c and lowered total/LDL cholesterol in type 2 diabetes in an RCT.
- Coenzyme Q10 supplementation improves cholesterol efflux capacity and antiinflammatory properties of high-density lipoprotein in Chinese adults with dyslipidemia
PubMed ID: 35700592
In dyslipidemic adults CoQ10 improved HDL cholesterol efflux and reduced HDL inflammatory index—beneficial metabolic / lipid function effects.
- Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial
PubMed ID: 29936921
Ubiquinol lowered HbA1c and supported antioxidant enzymes while preserving HDL—metabolic benefits in T2DM.
- Effect of Coenzyme Q(10) on Insulin Resistance in Korean Patients with Prediabetes: A Pilot Single-Center, Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 30151373
Prediabetes RCT reduced HOMA-IR and free oxygen radicals—direct metabolic improvement.
- Effects of Coenzyme Q10 Supplementation on Gene Expressions Related to Insulin, Lipid, and Inflammation Pathways in Patients With Diabetic Nephropathy
PubMed ID: 29421772
Diabetic nephropathy study upregulated PPAR-γ and downregulated inflammatory genes—mechanistic metabolic benefits.
- Hormonal and Metabolic Effects of Coenzyme Q10 and/or Vitamin E in Patients With Polycystic Ovary Syndrome
PubMed ID: 30202998
PCOS RCT: CoQ10 (±vit E) reduced fasting glucose, insulin/HOMA-IR and total testosterone → strong metabolic effects.
- Effect of Coenzyme Q10 on Oxidative Stress, Glycemic Control and Inflammation in Diabetic Neuropathy: A Double Blind Randomized Clinical Trial
PubMed ID: 26255546
Diabetic neuropathy RCT: improved insulin sensitivity and reduced hs‑CRP with CoQ10 (200 mg/d) over 12 weeks.
- The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome
PubMed ID: 26385228
Metabolic syndrome RCT: improved serum insulin, HOMA‑IR and TAC after 8 weeks of 100 mg/day CoQ10.
- The Effect of Coenzyme Q10 Supplementation on Circulating Levels of Novel Adipokine Adipolin/CTRP12 in Overweight and Obese Patients with Type 2 Diabetes
PubMed ID: 27657997
Overweight/obese T2DM trial: 200 mg/day CoQ10 lowered HbA1c by ~0.7% (clinically relevant), though adipolin declined.
- The Effects of Coenzyme Q10 Supplementation on Glucose Metabolism, Lipid Profiles, Inflammation, and Oxidative Stress in Patients With Diabetic Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 29111905
CoQ10 100 mg/day in diabetic nephropathy improved insulin, HOMA‑IR and HbA1c and reduced oxidative markers (robust RCT evidence).
- The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial
PubMed ID: 27911471
PCOS trial (100 mg/day CoQ10) produced consistent improvements in fasting glucose, insulin and HOMA‑IR (randomized double‑blind evidence).
- Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals
PubMed ID: 29454678
In dyslipidemic adults, CoQ10 lowered triglycerides and HOMA‑IR and modestly lowered BP—good metabolic signals (randomized trial).
- Significant Changes in Metabolic Profiles after Intervention with Selenium and Coenzyme Q10 in an Elderly Population
PubMed ID: 31575091
Se+CoQ altered plasma metabolome (amino acids, 1,5-AG, uric acid) indicating metabolic modulation (combination).
Illness recovery (23)
- Coenzyme Q(10), vitamin E, selenium, and methionine in the treatment of chronic recurrent viral mucocutaneous infections
PubMed ID: 22079390
Nutriceutical adjunct containing CoQ10 accelerated lesion healing and reduced relapse rates in viral skin infections—evidence for faster recovery from infection (regimen includes CoQ10).
- Systematic evaluation of the effectiveness of Xuesaitong combined with nutraceutical drugs in the treatment of diabetic peripheral neuropathy
PubMed ID: 40501262
Combination therapy including nutraceuticals (CoQ10 among them) for diabetic neuropathy led to large symptomatic and electrophysiological recovery improvements (multi‑ingredient).
- Effect of coenzyme Q10 on post-extraction tissue healing in wisdom tooth Surgery: double-blind randomized clinical trial
PubMed ID: 40616597
Randomized trial after wisdom‑tooth extraction showed accelerated healing, fewer dry sockets and better physical/mental recovery with daily CoQ10.
- Effect of Coenzyme Q10 on early wound healing after recession coverage surgery with the modified coronally advanced tunnel technique and a connective tissue graft: A 6-month, triple-blinded, randomized, placebo-controlled pilot trial
PubMed ID: 38990401
Topical CoQ10 after gum surgery trended toward better root coverage and faster pain recovery (non‑significant but suggestive of faster healing).
- Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway
PubMed ID: 38281937
Post‑MI patients receiving CoQ10 had faster short‑term improvement in echocardiographic function and BNP after PCI—enhanced cardiac recovery.
- Effect of coenzyme Q10 supplementation on oxidative stress and clinical outcomes in patients with low levels of coenzyme Q10 admitted to the intensive care unit
PubMed ID: 34290862
CoQ10 shortened mechanical ventilation duration and ICU/hospital length of stay in ventilated trauma patients—clear enhanced recovery signal with biomarker support.
- Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects
PubMed ID: 32741773
Perioperative ubiquinol reduced myocardial injury markers and improved LVEF recovery at 6 months.
- Improved Health-Related Quality of Life, and More Days out of Hospital with Supplementation with Selenium and Coenzyme Q10 Combined. Results from a Double Blind, Placebo-Controlled Prospective Study
PubMed ID: 26482687
Selenium+CoQ10 associated with more days alive outside hospital and smaller decline in physical QoL — suggests improved recovery/maintenance.
- The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo-controlled clinical trial
PubMed ID: 24119199
Peri‑ESWL RCT: oral CoQ10 improved GFR and decreased urine injury markers—supports organ‑level recovery protection.
- The effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study
PubMed ID: 22595020
Objective nerve conduction improvements and symptom reduction in neuropathy imply better functional recovery.
- Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomised trial
PubMed ID: 20674497
Perioperative metabolic supplementation (including CoQ10) reduced myocardial injury markers and shortened postoperative stay — clinical recovery benefit (multicomponent).
- The role of oral coenzyme Q10 in patients undergoing coronary artery bypass graft surgery
PubMed ID: 18834786
Pre-op CoQ10 associated with fewer complications and shorter hospital stays after CABG—supports enhanced perioperative recovery (small RCT).
- Effect of coenzyme q10 on myopathic symptoms in patients treated with statins
PubMed ID: 17493470
Reduction in statin‑associated muscle pain can accelerate functional recovery from myalgia.
- Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue
PubMed ID: 15632821
Improved mitochondrial function and ex vivo contractile recovery suggests enhanced tissue recovery potential.
- Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis. A Randomized, Controlled, Multicenter Clinical Trial
PubMed ID: 29688760
Antioxidant‑enriched multivitamin including CoQ10 reduced inflammatory markers and lowered early pulmonary exacerbation risk — supports clinical recovery.
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
Ubiquinol improved cardiac function and energy biomarkers in HFpEF, consistent with improved clinical recovery/tolerance.
- Coenzyme Q10 combined with mild hypothermia after cardiac arrest: a preliminary study
PubMed ID: 15520321
Significant improvement in survival and neurological outcome after cardiac arrest implies enhanced recovery with CoQ10 adjunct.
- Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study
PubMed ID: 15188947
Symptomatic and functional improvements in severe HF indicate better recovery of function.
- Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction
PubMed ID: 12841346
Post-MI one-year Q10 treatment associated with fewer recurrent events and improved biomarkers—recovery/prognosis benefit.
- Protection by coenzyme Q10 of tissue reperfusion injury during abdominal aortic cross-clamping
PubMed ID: 8698756
Reduced biochemical reperfusion injury after aortic cross‑clamping—better postoperative tissue recovery.
- Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting
PubMed ID: 7979670
Fewer postoperative arrhythmias and lower oxidative markers indicate improved perioperative recovery.
- Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study
PubMed ID: 8241697
Reduced HF hospitalizations and complications in a 1‑year RCT implies better clinical recovery/stability.
- The clinical outcome of Montelukast versus co-enzyme Q10 in adult patients with sepsis: A randomized controlled clinical trial
PubMed ID: 40845766
In septic ICU patients CoQ10 shortened vasopressor duration and improved biomarkers, indicating faster physiologic recovery.
Blood circulation (21)
- Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial
PubMed ID: 21388622
CoQ10 improved flow‑mediated dilation (FMD) in ischemic LV dysfunction — direct evidence of improved endothelial/vascular function.
- Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes
PubMed ID: 12732401
Factorial RCT showed fenofibrate + CoQ10 (but not either alone) improved forearm endothelium‑dependent and independent vasodilation—direct evidence of improved microvascular function with CoQ10 in combination.
- Reduction in asymmetric dimethylarginine plasma levels by coenzyme Q10 supplementation in patients with type 2 diabetes mellitus
PubMed ID: 26140473
CoQ10 (200 mg/day) in type 2 diabetes reduced ADMA and increased NOx, biomarkers indicating improved endothelial function and circulation.
- Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction
PubMed ID: 9825179
In AMI patients CoQ10 (120 mg/day) associated with fewer angina episodes, arrhythmias and cardiac events — clinically relevant to cardiac circulation/health.
- Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease
PubMed ID: 10204818
Hydrosoluble CoQ10 added to antihypertensives reduced BP and oxidative stress in hypertensive coronary patients.
- Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes
PubMed ID: 12428181
In type 2 diabetes, CoQ10 (200 mg/day) modestly lowered systolic (~−6.1 mmHg) and diastolic BP and HbA1c — direct circulation/metabolic effects.
- Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction
PubMed ID: 18487480
CoQ10 supplementation in type 2 diabetics raised body CoQ and produced a modest but significant reduction in 24‑h diastolic BP (~−2.2 mmHg), indicating vascular/blood pressure benefit.
- Effect of a hydrophilic and a hydrophobic statin on cardiac salvage after ST-elevated acute myocardial infarction - a pilot study
PubMed ID: 25262434
Rosuvastatin produced greater myocardial salvage and LVEF improvement and increased CoQ10/LDL‑C ratio vs atorvastatin after STEMI — improved myocardial perfusion/outcomes relevant to circulation.
- Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension
PubMed ID: 11780680
Isolated systolic hypertension: Q10 (60 mg twice daily) produced a substantial average systolic BP drop (~17.8 mmHg).
- Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus
PubMed ID: 11914748
Type II diabetic dyslipidemia: Q10 significantly improved flow-mediated dilation (endothelial function).
- Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study
PubMed ID: 17644511
In CAD patients CoQ10 enhanced endothelium‑dependent vasodilation and vascular antioxidant activity.
- Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia
PubMed ID: 19154996
CoQ10 lowered pre-eclampsia incidence (vascular disorder) in high‑risk pregnancies—supports vascular/ circulatory benefits.
- Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study
PubMed ID: 20720560
CoQ10 improved erectile function, reduced plaque/curvature in Peyronie's disease — vascular/ microcirculatory improvements likely contributed.
- Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: the FAITH randomized clinical trial
PubMed ID: 22858191
Randomized trial of aged garlic extract + CoQ10 showed significant improvements in pulse-wave velocity and endothelial function (combined intervention).
- The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial
PubMed ID: 25282031
Large CHF trial: fewer major cardiovascular events and lower CV mortality—consistent with improved cardiac function/circulation.
- Effect of reduced coenzyme Q10 (ubiquinol) supplementation on blood pressure and muscle damage during kendo training camp: a double-blind, randomized controlled study
PubMed ID: 25369277
Ubiquinol lowered diastolic blood pressure during intense training—direct circulatory effect in small trial.
- Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial
PubMed ID: 26375288
Selenium+CoQ10 decreased sP‑selectin and CRP—markers linked to atherothrombosis and vascular health.
- Middle-Term Dietary Supplementation with Red Yeast Rice Plus Coenzyme Q10 Improves Lipid Pattern, Endothelial Reactivity and Arterial Stiffness in Moderately Hypercholesterolemic Subjects
PubMed ID: 27055107
Combined red yeast rice + CoQ10 product improved endothelial reactivity and reduced pulse wave velocity (better vascular function) in mildly hypercholesterolemic adults.
- Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial
PubMed ID: 28684614
Ubiquinol improved endothelial function in antiphospholipid syndrome patients (randomized crossover trial).
- Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial
PubMed ID: 30835327
CHF RCT improved clinical outcomes and EF, consistent with improved cardiac/circulatory function.
- Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial
PubMed ID: 32326664
Ubiquinol RCT improved flow-mediated dilation (FMD) and increased NO metabolites — clear endothelial/circulatory benefit.
Immune support (21)
- Effects of coenzyme Q10 supplementation on matrix metalloproteinases and DAS-28 in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 31392559
RA RCT showed reduced disease activity and MMP-3, consistent with immunomodulatory effect.
- Modulation of Metabolomic Profile in Sepsis According to the State of Immune Activation
PubMed ID: 39418210
Sepsis metabolomics identified ubiquinone/CoQ biosynthesis pathway enrichment in hyperinflammatory states, implicating CoQ metabolism in immune dysregulation.
- Effects of an Intervention with Selenium and Coenzyme Q(10) on Five Selected Age-Related Biomarkers in Elderly Swedes Low in Selenium: Results That Point to an Anti-Ageing Effect-A Sub-Analysis of a Previous Prospective Double-Blind Placebo-Controlled Randomised Clinical Trial
PubMed ID: 37443807
Large selenium+CoQ10 RCT shifted multiple inflammation‑related biomarkers; attribution to CoQ10 is indirect (combination therapy).
- Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden
PubMed ID: 35381849
Selenium+CoQ10 lowered inflammatory/oxidative latent factors in elderly cohort; combined intervention caveat.
- Effect of coenzyme Q10 supplementation on oxidative stress and clinical outcomes in patients with low levels of coenzyme Q10 admitted to the intensive care unit
PubMed ID: 34290862
Critically ill trauma RCT: CoQ10 lowered IL‑6 and markers of oxidative stress, consistent with immune/inflammatory modulation.
- The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome
PubMed ID: 34664527
PCOS trial: CoQ10 lowered hs‑CRP and other inflammatory/oxidative markers, indicating immune/inflammation benefit.
- A randomized controlled trial on the coloprotective effect of coenzyme Q10 on immune-inflammatory cytokines, oxidative status, antimicrobial peptides, and microRNA-146a expression in patients with mild-to-moderate ulcerative colitis
PubMed ID: 33620550
RCT in ulcerative colitis showed CoQ10 reduced IL‑17 and NF‑κB activity—direct anti‑inflammatory / immune‑modulating evidence.
- Coenzyme Q(10), vitamin E, selenium, and methionine in the treatment of chronic recurrent viral mucocutaneous infections
PubMed ID: 22079390
Two controlled trials of a nutriceutical regimen containing CoQ10 showed faster healing and fewer relapses of viral warts/herpes, supporting enhanced antiviral/immune response (regimen includes CoQ10).
- The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients
PubMed ID: 32544011
PCOS RCT demonstrated significant reductions in TNF-α, hs-CRP, IL-6 (anti-inflammatory effect).
- Coenzyme Q10 improves the survival and reduces inflammatory markers in septic patients
PubMed ID: 32115970
Sepsis RCT showed reduced TNF-α/MDA and lower in-hospital mortality → strong immune/inflammatory effect.
- Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial
PubMed ID: 24621064
RRMS RCT: significant reductions in TNF‑α, IL‑6 and MMP‑9 (direct anti‑inflammatory/immune biomarker effects).
- Effects of Coenzyme Q10 Supplementation on Gene Expressions Related to Insulin, Lipid, and Inflammation Pathways in Patients With Diabetic Nephropathy
PubMed ID: 29421772
Diabetic nephropathy trial downregulated IL-1 and TNFα gene expression (anti-inflammatory).
- Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial
PubMed ID: 26342738
RA trial showed attenuation of TNF-α and reduced lipid peroxidation, indicating immune/inflammatory modulation.
- Idebenone reduces respiratory complications in patients with Duchenne muscular dystrophy
PubMed ID: 27238057
Idebenone reduced respiratory infections/events and antibiotic use in Duchenne patients (clinical immune/infection outcome).
- Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis. A Randomized, Controlled, Multicenter Clinical Trial
PubMed ID: 29688760
Antioxidant‑enriched multivitamin including CoQ10 raised systemic CoQ10, reduced inflammatory markers and halved early pulmonary exacerbation risk — plausible immune/host‑defense benefit.
- Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal disease: a randomized, double-blind, placebo-controlled, multicenter trial
PubMed ID: 25746727
Multi‑nutrient drink including CoQ10 reduced HHV7 reactivation and improved autonomic markers in hemodialysis patients; supports antiviral/immune benefit (multi‑ingredient trial).
- Coenzyme Q10 administration increases antibody titer in hepatitis B vaccinated volunteers--a single blind placebo-controlled and randomized clinical study
PubMed ID: 10416052
Randomized trial: dose-related ↑ hepatitis B antibody titers (up to +57%)—direct immunopotentiation.
- Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock
PubMed ID: 21827677
Observational study: markedly lower plasma CoQ10 in septic shock and inverse correlations with inflammatory markers — supports link to immune/inflammatory state.
- Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis
PubMed ID: 23659338
RRMS RCT: decreased MDA and increased SOD plus reduced inflammatory milieu—supports immune modulation.
- A pilot double-blind, placebo-controlled, randomized clinical trial of MitoQ in the treatment of septic shock: evaluating its effects on clinical outcomes and oxidative stress biomarker
PubMed ID: 40820063
MitoQ improved antioxidant enzymes and reduced oxidative damage in septic shock, suggesting modulation of immune-related oxidative stress.
- The clinical outcome of Montelukast versus co-enzyme Q10 in adult patients with sepsis: A randomized controlled clinical trial
PubMed ID: 40845766
In septic ICU patients CoQ10 reduced inflammatory/oxidative markers and shortened vasopressor use, consistent with immune/inflammatory benefit.
Mental clarity (11)
- The effect of creatine and coenzyme q10 combination therapy on mild cognitive impairment in Parkinson's disease
PubMed ID: 25792086
Creatine+CoQ10 slowed cognitive decline in PD‑MCI (combination therapy; CoQ10 contribution plausible but not isolated).
- Idebenone, a new drug in the treatment of cognitive impairment in patients with dementia of the Alzheimer type
PubMed ID: 7988944
Idebenone (CoQ analogue) RCT in Alzheimer’s: improved memory/attention/orientation—relevant but indirect.
- A controlled study of 2 doses of idebenone in the treatment of Alzheimer's disease
PubMed ID: 9267856
Idebenone trial: improved cognitive scores (ADAS) vs placebo—supports cognitive benefit of CoQ analogue.
- Sustained efficacy and safety of idebenone in the treatment of Alzheimer's disease: update on a 2-year double-blind multicentre study
PubMed ID: 9850939
Long-term idebenone produced dose-dependent cognitive/functional benefits in mild–moderate AD (analogue data).
- Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline
PubMed ID: 12374491
High-dose CoQ10 (Parkinson's) slowed functional decline—relevant to cognition/mental function in neurodegeneration.
- Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial
PubMed ID: 15728298
Migraine trial reduced attack frequency and headache-days — likely to improve cognitive clarity and reduced analgesic fog.
- Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
PubMed ID: 25916335
Migraine combo RCT improved HIT‑6 and pain intensity; secondary benefit likely improves cognitive/clarity during attacks.
- Coenzyme Q10 supplementation in acute ischemic stroke: Is it beneficial in short-term administration?
PubMed ID: 30404563
Acute ischemic stroke trial produced modest improvements in NIHSS and MMSE (short-term cognition/clarity).
- Coenzyme Q10 in the Treatment of Attention Deficit Hyperactivity Disorder in Children: A Randomized Controlled Trial
PubMed ID: 34819012
In ADHD add‑on trial, CoQ10 reduced overall ADHD symptoms and hyperactivity—improvements in attention/behavior relevant to mental clarity.
- Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study
PubMed ID: 39999976
Acute ischemic stroke trial increased BDNF and reduced oxidative stress—biomarkers consistent with neuroprotective/clarity effects.
- Treatment of Alzheimer's disease with a cholinesterase inhibitor combined with antioxidants
PubMed ID: 20224285
Antioxidant formula including CoQ10 added to donepezil reduced oxidative stress and produced small cognitive improvements.
Exercise recovery (13)
- The effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study
PubMed ID: 22595020
Diabetic neuropathy trial showed improved nerve function and reduced oxidative damage; may support muscle function recovery indirectly.
- Effects of Coenzyme Q10 Supplementation on Physical Function Adaptations to High-Intensity Interval Training in Older Adults
PubMed ID: 41470903
CoQ10 plus HIIT produced greater gains in lower-body strength/power and modest muscle mass increase (supports recovery/adaptation).
- Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise
PubMed ID: 32041223
Ubiquinol before exercise modulated inflammatory signaling and preserved RBCs—helps post-exercise recovery.
- Coenzyme q10 liquid supplementation in dyslipidemic subjects with statin-related clinical symptoms: a double-blind, randomized, placebo-controlled study
PubMed ID: 31695332
Statin-intolerant patients on liquid CoQ10 had marked reductions in myalgia scores and CPK—strong muscle recovery/relief signal.
- The effect of short-term coenzyme Q10 supplementation and pre-cooling strategy on cardiac damage markers in elite swimmers
PubMed ID: 29498347
Elite swimmers: CoQ10 blunted exercise-related rises in cardiac damage markers and oxidative stress after intensive training (recovery-related).
- Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study
PubMed ID: 25375075
Mild–moderate statin‑symptoms RCT: CoQ10 (50 mg BID) reduced pain severity and interference over 30 days.
- Coenzyme Q(10) and selenium in statin-associated myopathy treatment
PubMed ID: 23458201
Statin‑associated myopathy pilot: substantial reductions in muscle pain and tiredness with CoQ10 (with selenium co‑supplementation).
- Effect of coenzyme q10 on myopathic symptoms in patients treated with statins
PubMed ID: 17493470
Randomized double‑blind trial in statin‑treated patients showed 100 mg/day CoQ10 reduced muscle pain severity by ~40% and interference by ~38% vs vitamin E.
- Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue
PubMed ID: 15632821
Preoperative CoQ10 improved mitochondrial function and ex vivo myocardial and muscle contractile recovery after hypoxia.
- The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial
PubMed ID: 30612463
CoQ10 + L‑carnitine lowered lactate and reduced migraine severity/duration; lactate lowering suggests improved muscle metabolic recovery physiology.
- Effect of Short-term Coenzyme Q10 Supplementation and Precooling on Serum Endogenous Antioxidant Enzymes of Elite Swimmers
PubMed ID: 28486329
CoQ10 attenuated exercise‑related perturbations in antioxidant enzymes during intense training, supporting muscle recovery.
- Effects of 12 Weeks of Essential Amino Acids (EAA)-Based Multi-Ingredient Nutritional Supplementation on Muscle Mass, Muscle Strength, Muscle Power and Fatigue in Healthy Elderly Subjects: A Randomized Controlled Double-Blind Study
PubMed ID: 31021358
Elderly participants taking a multi‑ingredient supplement including CoQ10 showed gains in appendicular lean mass, MVC and peak power—directly relevant to muscle recovery and function (indirect attribution).
- Effect of oral CoQ(10) supplementation along with precooling strategy on cellular response to oxidative stress in elite swimmers
PubMed ID: 30058646
Two‑week CoQ10 in elite swimmers reduced exercise‑related oxidative stress and muscle/liver damage markers (CK)—strong support for muscle recovery in athletes.
Workout performance (9)
- Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study
PubMed ID: 8241697
Large CHF RCT reported clinically significant reductions in hospitalizations and complications consistent with preserved/ improved physical capacity.
- Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study
PubMed ID: 15188947
6‑min walk improvement and symptom reductions in end‑stage HF reflect better physical performance.
- The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial
PubMed ID: 30612463
Lower lactate and reduced migraine disability with CoQ10 + L‑carnitine suggest metabolic/clinical performance benefits.
- Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study
PubMed ID: 17824295
Significant 6‑minute walk distance improvement in ubiquinol + L‑carnitine heart failure patients indicates improved functional performance.
- Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study
PubMed ID: 17644511
Improved exercise oxygen consumption and endothelial function in CAD patients — supports physical performance gains.
- Supplementation with Qter(®) and Creatine improves functional performance in COPD patients on long term oxygen therapy
PubMed ID: 30170808
COPD patients (CoQ10 + creatine) improved 6MWT and dyspnea—functional performance gains (confounded).
- Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial
PubMed ID: 30835327
CHF trial improved clinical outcomes and LVEF over 2 years—translates to improved physical capacity in heart failure patients.
- Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise
PubMed ID: 32041223
Ubiquinol blunted adverse hematologic/inflammatory exercise responses and increased angiogenic factors—supports performance.
- Effects of Coenzyme Q10 Supplementation on Physical Function Adaptations to High-Intensity Interval Training in Older Adults
PubMed ID: 41470903
In older adults doing HIIT, CoQ10 produced larger gains in lower-body strength/power and modest muscle mass increase.
Eye health (9)
- Salvage of the retinal ganglion cells in transition phase in Alzheimer's disease with topical coenzyme Q10: is it possible?
PubMed ID: 31781880
Topical CoQ10 in AD patients increased RNFL and GCIPL thickness on OCT (local retinal structural benefit).
- Efficacy of eyedrops containing cross-linked hyaluronic acid and coenzyme Q10 in treating patients with mild to moderate dry eye
PubMed ID: 28777385
Randomized topical study (XLHA + CoQ10) improved OSDI symptoms, corneal staining and MGD vs HA alone.
- Circulating levels of reactive oxygen species in patients with nonproliferative diabetic retinopathy and the influence of antioxidant supplementation: 6-month follow-up
PubMed ID: 25686055
Antioxidant supplement including CoQ10 reduced ROS and modestly reduced retinal thickness in diabetic retinopathy.
- The effect of ubiquinone and combined antioxidant therapy on oxidative stress markers in non-proliferative diabetic retinopathy: A phase IIa, randomized, double-blind, and placebo-controlled study
PubMed ID: 26321469
NPDR RCT: CoQ10 (or antioxidants) reduced lipid peroxidation/NO metabolites and increased TAC—direct ocular oxidative stress improvement.
- Persistence of the treatment effect of idebenone in Leber's hereditary optic neuropathy
PubMed ID: 23388409
Follow‑up of RHODOS: visual benefits persisted ~30 months—supports durable eye‑related benefit.
- Effects of idebenone on color vision in patients with leber hereditary optic neuropathy
PubMed ID: 23263355
Idebenone (CoQ10 analogue) RCT in LHON: preserved/improved tritan color contrast and reduced vision worsening—strong ocular benefit.
- A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy
PubMed ID: 21788663
Idebenone (CoQ analogue) produced significant improvements in visual acuity and colour contrast in LHON patients in several analyses.
- The effects of topical coenzyme Q10 and vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate after cataract surgery: a clinical and in vivo confocal study
PubMed ID: 23011409
Randomized topical CoQ10 (with vitamin E) after cataract surgery sped corneal nerve recovery and improved tear‑film stability—strong direct ocular surface evidence.
- Application of Vitamin E + Coenzyme Q Therapy During FAKO + IOL Implantation
PubMed ID: 31391698
Intracameral vitE+CoQ10 during cataract surgery reduced early corneal edema and sped visual recovery (clinical ocular benefit).
Endurance (7)
- Effects of Coenzyme Q10 Supplementation on Physical Function Adaptations to High-Intensity Interval Training in Older Adults
PubMed ID: 41470903
CoQ10 plus HIIT improved lower-body strength/power and repetitions, consistent with greater stamina in older adults.
- Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise
PubMed ID: 32041223
Ubiquinol before strenuous exercise preserved RBC indices and modulated cytokines/angiogenic factors linked to endurance.
- Treatment effect of idebenone on inspiratory function in patients with Duchenne muscular dystrophy
PubMed ID: 27571420
Idebenone significantly slowed decline in inspiratory function and improved inspiratory flow reserve in DMD, reflecting clinically meaningful stamina/respiratory benefit.
- Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study
PubMed ID: 17644511
One‑month trial in CAD increased peak VO2 and improved O2 utilization.
- Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study
PubMed ID: 15188947
Patients awaiting heart transplant had significantly improved 6‑min walk distance and reduced symptoms after CoQ10.
- Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study
PubMed ID: 8241697
Large CHF trial reported clinical functional benefits (fewer hospitalizations/complications) compatible with preserved functional capacity/endurance.
- Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study
PubMed ID: 17824295
Ubiquinol + L‑carnitine improved 6‑minute walk distance markedly in heart failure patients (functional endurance gain).
Stress resilience (7)
- The clinical outcome of Montelukast versus co-enzyme Q10 in adult patients with sepsis: A randomized controlled clinical trial
PubMed ID: 40845766
Sepsis ICU patients on CoQ10 had improved inflammatory/oxidative markers and shorter vasopressor dependence, indicating resilience to physiologic stress.
- Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?
PubMed ID: 25386668
CFS trial showed reduced lipoperoxides and improved NAD+/ATP with CoQ10+NADH — improved cellular resilience to metabolic stress.
- Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting
PubMed ID: 7979670
Preop CoQ10 reduced oxidative stress markers and arrhythmias during/after CABG—improved physiologic stress response.
- Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial
PubMed ID: 24621064
RRMS RCT reduced systemic inflammatory markers which may reflect improved physiologic resilience to stressors.
- Coenzyme Q10 improves the survival and reduces inflammatory markers in septic patients
PubMed ID: 32115970
Sepsis RCT: reduced oxidative/inflammatory markers and mortality → supports resilience to severe physiological stress.
- Effect of coenzyme Q10 supplementation on oxidative stress and clinical outcomes in patients with low levels of coenzyme Q10 admitted to the intensive care unit
PubMed ID: 34290862
In critically ill trauma patients CoQ10 reduced IL‑6 and MDA and shortened ventilation/ICU stay—supports biological stress resilience during acute illness.
- A pilot double-blind, placebo-controlled, randomized clinical trial of MitoQ in the treatment of septic shock: evaluating its effects on clinical outcomes and oxidative stress biomarker
PubMed ID: 40820063
MitoQ improved antioxidant enzyme activity and reduced oxidative damage in septic shock—supporting stress‑resilience mechanisms.
Skin appearance (5)
- Effects of a Combination of Water-Soluble CoenzymeQ10 and Collagen on Skin Parameters and Condition:Results of a Randomised, Placebo-Controlled,Double-Blind Study
PubMed ID: 32120787
Multinutrient (with water-soluble CoQ10) RCT increased dermis density and reduced wrinkles vs placebo.
- The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study
PubMed ID: 27548886
Small RCT reported reduced visible signs of skin aging and preserved skin elasticity with oral CoQ10.
- Effective photoprotection of human skin against infrared A radiation by topically applied antioxidants: results from a vehicle controlled, double-blind, randomized study
PubMed ID: 25349107
Topical formulation including ubiquinone reduced IRA‑induced MMP‑1, a marker linked to photoaging—supports skin protection/radiance.
- A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins
PubMed ID: 25732262
Randomized 4‑week supplement containing CoQ10 improved photoaging VAS score, skin hydration, sebum and tonicity vs placebo (direct skin appearance outcome, multi‑ingredient product).
- Clinical and biochemical effects of coenzyme Q(10), vitamin E, and selenium supplementation to psoriasis patients
PubMed ID: 19041224
CoQ10 + vitamin E + selenium improved psoriasis severity and oxidative stress; direct skin clinical improvement suggests potential for better skin appearance (condition‑specific).
Mood balance (3)
- The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome
PubMed ID: 34664527
PCOS RCT showed significant reductions in depression (BDI) and anxiety (BAI) scores with CoQ10 vs placebo.
- Discovering the Potential Value of Coenzyme Q10 as an Adjuvant Treatment in Patients With Depression
PubMed ID: 38684047
Randomized adjunctive CoQ10 significantly reduced depressive symptoms (MADRS) and improved redox markers—strong direct mood evidence.
- Evaluating the Effect of Coenzyme Q10 Augmentation on Treatment of Bipolar Depression: A Double-Blind Controlled Clinical Trial
PubMed ID: 30106880
Double-blind RCT in bipolar depression showed clinically meaningful symptom improvement with CoQ10 augmentation.
Similar by evidence
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Products with Coenzyme Q10
Search all6182 products whose verified label declares Coenzyme Q10 — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.