Colostrum
17 benefits mapped to clinical evidence across supplements.
Dose per serving from products
178 products in our catalogue print how much Colostrum a serving holds.
Most common: 500 mg to 1 g, 32% of 178 products.
| Dose per serving | Products |
|---|---|
| 25 mg or less | 5 |
| 25 mg to 50 mg | 7 |
| 50 mg to 100 mg | 6 |
| 100 mg to 250 mg | 25 |
| 250 mg to 500 mg | 18 |
| 500 mg to 1 g | 57 |
| 1 g to 2.5 g | 32 |
| 2.5 g to 5 g | 23 |
| over 5 g | 5 |
Dose per serving from research
41 study groups in 34 studies say how much Colostrum participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 50 g to 100 g, 24% of 41 study groups.
| Daily dose | Study groups |
|---|---|
| 500 mg to 1 g | 8 |
| 1 g to 2.5 g | 3 |
| 2.5 g to 5 g | 2 |
| 5 g to 10 g | 5 |
| 10 g to 25 g | 8 |
| 25 g to 50 g | 5 |
| 50 g to 100 g | 10 |
Benefit Evidence
â IgG, uptake
â permeability, better absorption
â protein/AA, uptake
Research sources
Immune support (57)
- Probiotics and dietary counselling targeting maternal dietary fat intake modifies breast milk fatty acids and cytokines
PubMed ID: 21626296
Human dietary intervention altered colostrum cytokines that could affect neonatal immunity.
- High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented mothers are related to less immunoglobulin E-associated disease in infancy
PubMed ID: 26970335
Maternal omegaâ3 supplementation raised colostrum EPA/DHA and associated with fewer IgE allergic outcomes.
- Effects of perinatal vaccination on humoral and cellular immune responses in cows and young calves
PubMed ID: 8575972
Perinatal vaccination increased colostrum antibodies and calf immune responses (animal evidence).
- Effect of level and source of dietary selenium on concentrations of thyroid hormones and immunoglobulins in beef cows and calves
PubMed ID: 9581946
Cow selenium dosing changed colostrum IgG, showing nutrient effects on colostral immunity (animal).
- Effect of a mixture of micronutrients, but not of bovine colostrum concentrate, on immune function parameters in healthy volunteers: a randomized placebo-controlled study
PubMed ID: 17118191
Human RCT: lowâdose bovine colostrum concentrate produced no measurable immune benefit in healthy adults.
- Impact of maternal allergy and use of probiotics during pregnancy on breast milk cytokines and food antibodies and development of allergy in children until 5 years
PubMed ID: 22652586
Maternal milk/colostrum immune components associated with child allergy risk and were altered by probiotics (relevance to immune factors in colostrum).
- Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum
PubMed ID: 9877365
Immunoglobulins from immunized colostrum reduced rotavirus shedding and illness in children.
- Breast-feeding and the development of cows' milk protein allergy
PubMed ID: 11065065
Lower TGFâÎČ1 in colostrum associated with infant IgEâmediated allergy risk (immune modulation)
- Randomized, placebo-controlled, clinical trial of hyperimmunized chicken egg yolk immunoglobulin in children with rotavirus diarrhea
PubMed ID: 11176319
Passive antibodies (oral) sped viral clearance â supports immunoprotective action
- IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training
PubMed ID: 12133885
Colostrum raised salivary IgA in athletes (mucosal immune marker increased)
- Preoperative oral application of immunoglobulin-enriched colostrum milk and mediator response during abdominal surgery
PubMed ID: 11795674
Immunoglobulinâenriched colostrum lowered perioperative endotoxin and preserved ENC
- Concentrated bovine colostrum protein supplementation reduces the incidence of self-reported symptoms of upper respiratory tract infection in adult males
PubMed ID: 12923655
Human RCT (pooled): concentrated bovine colostrum reduced proportion reporting URTI symptoms over 7 weeksâstrong clinical immune-related endpoint.
- Efficacy of an infant formula containing anti-Escherichia coli colostral antibodies from hyperimmunized cows in preventing diarrhea in infants and children: a field trial
PubMed ID: 12839713
Infant RCT: colostral antibodies lowered diarrheal disease incidence/duration and increased growthâclear passive immune protection effect.
- Effect of probiotics and breastfeeding on the bifidobacterium and lactobacillus/enterococcus microbiota and humoral immune responses
PubMed ID: 16126047
Breastfeeding/probiotics study: colostrum sCD14 correlated with infant antibody-secreting cell responsesâlinks colostrum components to immune development.
- Protection against neonatal Escherichia coli diarrhoea in pigs by vaccination of sows with a new vaccine that contains purified enterotoxic E. coli virulence factors F4ac, F4ab, F5 and F6 fimbrial antigens and heat-labile E. coli enterotoxin (LT) toxoid
PubMed ID: 16219094
Sow vaccination study: vaccine-boosted colostrum strongly protected piglets from E. coliâdemonstrates colostrum's role in passive immunity.
- The effect of bovine colostrum supplementation on salivary IgA in distance runners
PubMed ID: 16676703
Distance runners: bovine colostrum produced large increase in salivary s-IgA, a mucosal immune marker linked to infection resistance.
- Short communication: Addition of milk replacer to colostrum whey: effect on immunoglobulin G passive transfer in Majorera kids
PubMed ID: 17430937
Colostrum whey mixed with milk replacer provided equivalent passive IgG transfer in kids, supporting colostrum's role in delivering immunoglobulins.
- A randomized, double-blind study comparing Clostridium difficile immune whey and metronidazole for recurrent Clostridium difficile-associated diarrhoea: efficacy and safety data of a prematurely interrupted trial
PubMed ID: 19086244
Colostrum-derived immune whey was as effective as metronidazole for recurrent C. difficile, showing pathogen-specific immune activity in humans.
- Efficacy of feeding plasma-derived commercial colostrum replacer for the prevention of transmission of Mycobacterium avium subsp paratuberculosis in Holstein calves
PubMed ID: 19405889
Large calf trial: a plasma-derived colostrum replacer reduced MAP infection risk long-term, supporting colostrum-based interventions for infection protection.
- Effect of maternal fish oil and seaweed extract supplementation on colostrum and milk composition, humoral immune response, and performance of suckled piglets
PubMed ID: 20453086
Maternal seaweed extract increased colostral IgG and piglet antibody levels; fish oil altered immune cell activityâcolostrum composition influenced offspring immunity.
- Comparison of passive transfer of immunity in neonatal dairy calves fed colostrum or bovine serum-based colostrum replacement and colostrum supplement products
PubMed ID: 20946083
Natural colostrum produced higher calf serum IgG and higher rates of adequate passive transfer versus replacer, indicating stronger immune transfer.
- Effect of bovine colostrum-based food supplement in the treatment of HIV-associated diarrhea in Northern Uganda: a randomized controlled trial
PubMed ID: 22161540
Large RCT in HIV patients: colostrum supplement increased CD4+ counts and improved clinical immune outcomes.
- Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers
PubMed ID: 21526980
Human challenge trials: hyperimmune bovine colostrum provided strong pathogenâspecific protection against ETEC.
- The effect of bovine colostrum on viral upper respiratory tract infections in children with immunoglobulin A deficiency
PubMed ID: 21801330
Doubleâblind trial in IgAâdeficient children: oral bovine colostrum markedly reduced infection severity.
- Improvement of growth performance and sanitary status of weaned piglets fed a bovine colostrum-supplemented diet
PubMed ID: 22079995
Piglet trials: improved postweaning health and reduced diarrhoea consistent with immune/protective effects.
- Heat-treated colostrum and reduced morbidity in preweaned dairy calves: results of a randomized trial and examination of mechanisms of effectiveness
PubMed ID: 22720957
Heatâtreated colostrum increased calf serum IgG and reduced morbidity, indicating enhanced passive immune transfer.
- A colostrum substitute prevents bovine neonatal pancytopenia (BNP) in a herd with previously BNP-affected calves
PubMed ID: 23227765
Prevents BNP in herd by avoiding maternal colostrum â repeated entry emphasizing disease-prevention relevance.
- A randomized controlled trial on preweaning morbidity, growth and mortality in Holstein heifers fed a lacteal-derived colostrum replacer or pooled maternal colostrum
PubMed ID: 23965249
Colostrum replacer reduced diarrhea and antibiotic treatments in calves, indicating improved early disease resistance.
- Effects of bovine colostrum supplementation on upper respiratory illness in active males
PubMed ID: 24200515
Human RCT in active men: bovine colostrum reduced URI days/episodes and blunted salivary bacterial load rise over winter.
- Efficacy of feeding a lacteal-derived colostrum replacer or pooled maternal colostrum with a low IgG concentration for prevention of failure of passive transfer in dairy calves
PubMed ID: 23822086
Large field trial: lacteal-derived colostrum replacer markedly raised neonatal serum IgG/TP and dramatically reduced failure of passive transfer.
- Colostrum replacer feeding regimen, addition of sodium bicarbonate, and milk replacer: the combined effects on absorptive efficiency of immunoglobulin G in neonatal calves
PubMed ID: 24534514
Adding sodium bicarbonate to colostrum replacer reduced IgG uptake in calves â important for immune transfer (negative/implementation finding).
- Effect of bovine colostrum intake on growth, reproductive parameters and survival in red kids
PubMed ID: 25356485
Goat-kid study: bovine colostrum supplementation reduced mortality and boosted sustained growth, consistent with improved immune resilience.
- Effect of cross-fostering and oral supplementation with colostrums on performance of newborn piglets
PubMed ID: 24492575
Oral colostrum raised blood IgG and tended to reduce piglet mortality â supports passive immune transfer.
- Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh
PubMed ID: 25648738
Maternal B12 increased vaccineâspecific IgA in colostrum and improved infant inflammatory markers (immune benefit mediated via colostrum).
- A randomized clinical trial evaluating metabolism of colostral and plasma derived immunoglobulin G in Jersey bull calves
PubMed ID: 25858814
Colostrum feeding in calves produced much higher/longer IgG and lower mortality vs plasma (strong immune protection in neonates).
- Effect of colostrum heat treatment and bacterial population on immunoglobulin G absorption and health of neonatal calves
PubMed ID: 25935243
Reducing bacteria/heatâtreating colostrum improved IgG uptake and tended to reduce early diarrhea â supports better immune/passive transfer.
- Oropharyngeal colostrum administration in extremely premature infants: an RCT
PubMed ID: 25624376
Oropharyngeal mother's colostrum in extremely preterm infants markedly raised sIgA/lactoferrin and reduced clinical sepsis (strong human RCT evidence).
- Yeast product supplementation modulated humoral and mucosal immunity and uterine inflammatory signals in transition dairy cows
PubMed ID: 25726103
Yeast supplement raised some systemic/mucosal antibody markers (indirect immune signal relevant to colostrum context).
- Anti-bovine herpesvirus and anti-bovine viral diarrhea virus antibody responses in pregnant Holstein dairy cattle following administration of a multivalent killed virus vaccine
PubMed ID: 26413830
Prepartum vaccination of cows greatly increased colostral neutralizing antibody titers (colostrum as antibody source).
- Gamma delta T cells are early responders to Mycobacterium avium ssp. paratuberculosis in colostrum-replete Holstein calves
PubMed ID: 27614838
Animal data: colostrum-replete calves had higher γΎ T-cell representation and earlier cellular responsesâsupports immunologic role.
- Oropharyngeal Colostrum Administration in Very Low Birth Weight Infants: A Randomized Controlled Trial
PubMed ID: 28617764
Oral colostrum priming raised salivary lactoferrin (an antimicrobial peptide) in very low birth weight infants.
- Prophylactic Efficacy of Hyperimmune Bovine Colostral Antiadhesin Antibodies Against Enterotoxigenic Escherichia coli Diarrhea: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial
PubMed ID: 28541500
Direct, randomized human challenge trial: orally administered hyperimmune bovine colostral IgG provided strong protection vs ETEC.
- The effects of bovine colostrum supplementation on in vivo immunity following prolonged exercise: a randomised controlled trial
PubMed ID: 29274034
Bovine colostrum preserved antigen-specific skin Tâcell responses after prolonged exercise in humans, indicating immune-supporting effects.
- Oropharyngeal Administration of Colostrum Increases Salivary Secretory IgA Levels in Very Low-Birth-Weight Infants
PubMed ID: 28575910
Pilot RCT in VLBW infants: oropharyngeal maternal colostrum increased salivary sIgA (mucosal immune marker).
- Hyperimmune Bovine Colostral Anti-CS17 Antibodies Protect Against Enterotoxigenic Escherichia coli Diarrhea in a Randomized, Doubled-Blind, Placebo-Controlled Human Infection Model
PubMed ID: 30897198
Human challenge RCT: targeted bovine IgG prevented infection symptomsâstrong pathogenâspecific immune protection.
- Oral delivery of Hyperimmune bovine serum antibodies against CS6-expressing enterotoxigenic Escherichia coli as a prophylactic against diarrhea
PubMed ID: 32167011
Human challenge RCT: oral bovine hyperimmune antibodies against wholeâcell ETEC halved moderateâsevere diarrhea (immune protection).
- Oropharyngeal administration of colostrum for preventing necrotizing enterocolitis and late-onset sepsis in preterm infants with gestational ageââ€â32âweeks: a pilot single-center randomized controlled trial
PubMed ID: 34419090
Preterm RCT: oropharyngeal maternal colostrum reduced lateâonset sepsis and NEC, consistent with improved neonatal immune outcomes.
- Gut priming with bovine colostrum and T regulatory cells in preterm neonates: a randomized controlled trial
PubMed ID: 33446924
Preterm infant RCT demonstrated increased regulatory Tâcell percentages after bovine colostrumâdirect immunologic modulation.
- Oral Application of Colostrum and Mother's Own Milk in Preterm Infants-A Randomized, Controlled Trial
PubMed ID: 35006497
Oropharyngeal application of motherâs colostrum in preterms reduced lateâonset sepsis and a composite adverse neonatal outcome (clinical immune benefit).
- Improved physical disability and nutritional status by bovine colostrum supplementation in adults with traumatic peri-trochanteric femoral fracture: A randomized, controlled, clinical trial
PubMed ID: 38042695
Postâoperative colostrum improved lymphocyte counts and markers of immunity alongside nutrition in femur fracture patients.
- Long Duration of Oral Care Using Mother's Own Milk Influences Oral Microbiota and Clinical Outcomes in Very-low-birthweight Infants: Randomized Controlled Trial
PubMed ID: 37343216
RANDOMIZED trial preserved beneficial oral taxa and reduced clinical sepsis in VLBW infants receiving prolonged oropharyngeal motherâs milk care (colostrum related).
- Moderate Dose Bovine Colostrum Supplementation in Prevention of Upper Respiratory Tract Infections in Medical University Students: A Randomized, Triple Blind, Placebo-Controlled Trial
PubMed ID: 37111143
Tripleâblind RCT in higherârisk students showed reduced URTI days/severity and improved wellâbeing with moderateâdose colostrum.
- Six Weeks of Supplementation with Bovine Colostrum Effectively Reduces URTIs Symptoms Frequency and Gravity for Up to 20 Weeks in Pre-School Children
PubMed ID: 37630816
Wellâpowered pediatric RCT showed large, sustained reductions in URTI frequency/severity after shortâcourse bovine colostrum.
- Therapeutic interventions targeting enteropathy in severe acute malnutrition modulate systemic and vascular inflammation and epithelial regeneration
PubMed ID: 39662176
Reduced circulating endotoxin suggests lowered systemic immune activation/inflammatory burden.
- Does oral care with mother's colostrum reduce the risk of late-onset sepsis in preterm infants? A randomized clinical trial
PubMed ID: 39973530
Large reductions in late-onset sepsis and mortality with oropharyngeal mother's colostrum indicate strong immune benefit in infants.
- Investigating the effect of oropharyngeal colostrum in the prevention of late-onset sepsis in preterm infants: a randomized controlled trial
PubMed ID: 40389508
Clinically meaningful lower sepsis rates (not statistically definitive) and faster feedingâconsistent immune advantage.
- The Effect of Oral Immunotherapy on Preterm Neonates: A Promising Adjuvant Therapy in a Clinical Trial Study
PubMed ID: 40690903
Significant reductions in sepsis and shorter stays with oropharyngeal colostrum support immune protection.
Gut health (39)
- Therapeutic interventions targeting enteropathy in severe acute malnutrition modulate systemic and vascular inflammation and epithelial regeneration
PubMed ID: 39662176
Direct increases in GLP-2 and angiopoietin plus reduced LPS provide strong evidence for enhanced intestinal repair and reduced leak.
- A new risk factor for neonatal vancomycin-resistant Enterococcus colonisation: bacterial probiotics
PubMed ID: 25163639
Outbreak analysis showed probiotic product (including colostrum) associated with altered VRE colonisation â microbiome impact signal.
- Metabolomics reveals changes in levels of fecal branched chain amino acids and organic acids in very preterm infants fed human milk fortified with bovine colostrum
PubMed ID: 39581179
Preterm RCT: bovine colostrum fortifier produced marked changes in fecal metabolome relevant to gut function.
- Hyperimmune cow colostrum reduces diarrhoea due to rotavirus: a double-blind, controlled clinical trial
PubMed ID: 8652974
Hyperimmune colostrum reduced rotavirus diarrhea duration and stool output in children.
- Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum
PubMed ID: 9877365
Oral immunoglobulins improved rotavirus outcomes and decreased pathogen burden.
- Preoperative oral application of immunoglobulin-enriched colostrum milk and mediator response during abdominal surgery
PubMed ID: 11795674
Periâop immunoglobulin colostrum lowered endotoxin and preserved ENC (gut barrier benefit)
- Efficacy of an infant formula containing anti-Escherichia coli colostral antibodies from hyperimmunized cows in preventing diarrhea in infants and children: a field trial
PubMed ID: 12839713
Infant RCT: fewer/shorter diarrheal episodes with colostral antibodiesâdirect improvement in gut health.
- Effect of probiotics and breastfeeding on the bifidobacterium and lactobacillus/enterococcus microbiota and humoral immune responses
PubMed ID: 16126047
Breastfeeding and probiotics increased fecal Bifidobacterium/Lactobacillus counts and colostrum sCD14 correlated with immune markersâsupports microbiome interactions.
- Effects of epidermal growth factor on atrophic enteritis in piglets induced by experimental porcine epidemic diarrhoea virus
PubMed ID: 17574457
EGF treatment accelerated villous recovery and crypt proliferation in PEDV-infected piglets; EGF is a known colostrum growth factor supporting mucosal repair.
- A randomized, double-blind study comparing Clostridium difficile immune whey and metronidazole for recurrent Clostridium difficile-associated diarrhoea: efficacy and safety data of a prematurely interrupted trial
PubMed ID: 19086244
Human RCT: colostrum-derived immune whey performed comparably to metronidazole for recurrent C. difficile, indicating meaningful gut-health benefit against a major gut pathogen.
- Effect of enteral IGF-1 supplementation on feeding tolerance, growth, and gut permeability in enterally fed premature neonates
PubMed ID: 18223378
Enteral IGF-1 (a colostrum trophic factor) transiently improved gut barrier function (lower permeability) in very preterm infants.
- Probiotic lactobacilli in breast milk and infant stool in relation to oral intake during the first year of life
PubMed ID: 19525871
Oral L. reuteri increased detection of that probiotic in colostrum and infant stool, demonstrating transmission and potential microbiome modulation via colostrum.
- Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers
PubMed ID: 21526980
Human ETEC challenge RCTs demonstrate potent pathogenâspecific protective effects on gut health (reduced diarrhoea/stools/pain).
- Improvement of growth performance and sanitary status of weaned piglets fed a bovine colostrum-supplemented diet
PubMed ID: 22079995
Large piglet trials: improved intake, growth and reduced diarrhoea indicating durable gut health benefits.
- Heat-treated colostrum and reduced morbidity in preweaned dairy calves: results of a randomized trial and examination of mechanisms of effectiveness
PubMed ID: 22720957
Heatâtreated colostrum increased serum IgG and lowered scours and morbidity in calvesâsupports gut health via improved passive immunity and lower coliforms.
- A randomized controlled trial on preweaning morbidity, growth and mortality in Holstein heifers fed a lacteal-derived colostrum replacer or pooled maternal colostrum
PubMed ID: 23965249
Robust calf RCT: colostrum replacer decreased diarrhea and antibiotic use â strong evidence of gut-health benefits in neonates.
- Effect of bovine colostrum intake on growth, reproductive parameters and survival in red kids
PubMed ID: 25356485
Supplemented goat kids had long-term growth benefits and large mortality reduction, supporting improved neonatal gut/health status.
- Effect of bovine colostrum feeding in comparison with milk replacer and natural feeding on the immune responses and colonisation of enterotoxigenic Escherichia coli in the intestinal tissue of piglets
PubMed ID: 25743486
Bovine colostrum reduced intestinal E. coli colonization and diarrhoea in piglets (strong gutâhealth signal).
- Effect of colostrum heat treatment and bacterial population on immunoglobulin G absorption and health of neonatal calves
PubMed ID: 25935243
Lower bacterial contamination/heat treatment of colostrum improved IgG uptake and tended to reduce scour days (improves neonatal gut outcomes).
- Oropharyngeal colostrum administration in extremely premature infants: an RCT
PubMed ID: 25624376
Oropharyngeal colostrum increased mucosal markers (sIgA, lactoferrin) and reduced sepsis in preterms â suggests mucosal protection/repair capacity.
- Administration of a multistrain probiotic product (VSL#3) to women in the perinatal period differentially affects breast milk beneficial microbiota in relation to mode of delivery
PubMed ID: 25836922
Maternal VSL#3 probiotic increased lactobacilli and bifidobacteria in colostrum/milk (direct microbiome effect in milk).
- Prophylactic Efficacy of Hyperimmune Bovine Colostral Antiadhesin Antibodies Against Enterotoxigenic Escherichia coli Diarrhea: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial
PubMed ID: 28541500
Oral hyperimmune colostrum protected against enteric ETEC infection in humans, directly improving gut health outcomes.
- Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A randomized, double-blind, placebo-controlled study
PubMed ID: 30551120
ICU RCT: enteral colostrum lowered zonulin/endotoxin and decreased diarrheaârobust clinical gut benefit.
- Hyperimmune Bovine Colostral Anti-CS17 Antibodies Protect Against Enterotoxigenic Escherichia coli Diarrhea in a Randomized, Doubled-Blind, Placebo-Controlled Human Infection Model
PubMed ID: 30897198
Targeted bovine IgG prevented ETEC diarrhea in challenged adultsâdirect gut pathogen protection.
- Oropharyngeal Administration of Mother's Milk Prior to Gavage Feeding in Preterm Infants: A Pilot Randomized Control Trial
PubMed ID: 31062377
Preterm trial: oropharyngeal mothers' milk lowered Klebsiella colonization and accelerated feeding/shorter stay (microbial/gut benefit).
- Bovine Colostrum in the Treatment of Acute Diarrhea in Children: A Double-Blinded Randomized Controlled Trial
PubMed ID: 31168590
Pediatric RCT: adjunct bovine colostrum reduced vomiting/diarrhea and disease severity in acute gastroenteritis.
- Post-Delivery Milking Delay Influence on the Effect of Oral Supplementation with Bovine Colostrum as Measured with Intestinal Permeability Test
PubMed ID: 32987647
Randomized human trial: colostrum harvested 2 h postpartum significantly reduced intestinal permeability (L/M test).
- Oral delivery of Hyperimmune bovine serum antibodies against CS6-expressing enterotoxigenic Escherichia coli as a prophylactic against diarrhea
PubMed ID: 32167011
Human challenge RCT: oral bovine hyperimmune antibodies reduced moderateâsevere ETEC diarrhea â gut protection evidence.
- Oropharyngeal administration of colostrum for preventing necrotizing enterocolitis and late-onset sepsis in preterm infants with gestational ageââ€â32âweeks: a pilot single-center randomized controlled trial
PubMed ID: 34419090
Preterm RCT: oropharyngeal maternal colostrum markedly lowered NEC and lateâonset sepsis and sped enteral feedingâstrong neonatal gut health evidence.
- The effect of bovine colostrum/egg supplementation compared with corn/soy flour in young Malawian children: a randomized, controlled clinical trial
PubMed ID: 33330913
Large RCT in infants showed reduced stunting and subgroup normalization of gut permeability (%L) in severe EEDâdirect gut health evidence.
- A Randomized, Controlled Study to Investigate How Bovine Colostrum Fortification of Human Milk Affects Bowel Habits in Preterm Infants (FortiColos Study)
PubMed ID: 36432444
BC fortifier in preterms produced softer stools, better abdominal scores and no increased feeding intoleranceâclinically meaningful gut effects.
- Long Duration of Oral Care Using Mother's Own Milk Influences Oral Microbiota and Clinical Outcomes in Very-low-birthweight Infants: Randomized Controlled Trial
PubMed ID: 37343216
Randomized trial showed prolonged oropharyngeal maternal milk preserved beneficial oral taxa (Bifidobacterium, Faecalibacterium) vs sterile water and reduced sepsis.
- Do preterm infants' retinas like bovine colostrum? A randomized controlled trial
PubMed ID: 39427215
Smallâdose BC in preterms improved early weight and lowered CRP, suggesting improved gut/systemic interaction.
- Malnutrition enteropathy in Zambian and Zimbabwean children with severe acute malnutrition: A multi-arm randomized phase II trial
PubMed ID: 38632262
In severe acute malnutrition, colostrum increased crypt depth and reduced CRPâdirect evidence of mucosal repair.
- Gut microbiota development in very preterm infants following fortification of human milk
PubMed ID: 39982063
Bovine colostrum fortifier produced modest compositional shifts in very preterm infant microbiota.
- Does oral care with mother's colostrum reduce the risk of late-onset sepsis in preterm infants? A randomized clinical trial
PubMed ID: 39973530
Earlier feeding and fewer infections in preterm infants indicate improved gut function and resilience.
- Investigating the effect of oropharyngeal colostrum in the prevention of late-onset sepsis in preterm infants: a randomized controlled trial
PubMed ID: 40389508
Faster achievement of full enteral feeding and lower clinical sepsis suggest benefits to gut function.
- The Effect of Oral Immunotherapy on Preterm Neonates: A Promising Adjuvant Therapy in a Clinical Trial Study
PubMed ID: 40690903
Oropharyngeal colostrum shortened stays and sped feeding, implying improved gut adaptation.
- Effect of one prophylactic dose of azithromycin on Bifidobacterium infantis colonization in infants from the Mumta trial
PubMed ID: 39855335
Early maternal colostrum strongly associated with higher B. infantis colonization and lower pathogen counts in infants.
Digestive support (24)
- Hyperimmune Bovine Colostral Anti-CS17 Antibodies Protect Against Enterotoxigenic Escherichia coli Diarrhea in a Randomized, Doubled-Blind, Placebo-Controlled Human Infection Model
PubMed ID: 30897198
Human RCT: bovine antiâCS17 colostral antibodies fully prevented ETEC watery diarrhea (strong, direct effect).
- Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A randomized, double-blind, placebo-controlled study
PubMed ID: 30551120
ICU RCT: enteral bovine colostrum reduced diarrhea incidence and permeability biomarkers vs placebo.
- Prophylactic Efficacy of Hyperimmune Bovine Colostral Antiadhesin Antibodies Against Enterotoxigenic Escherichia coli Diarrhea: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial
PubMed ID: 28541500
Hyperimmune bovine colostrum markedly reduced ETEC diarrhea in a human challenge, directly improving digestive symptoms.
- Effect of crofelemer extract on severity and consistency of experimentally induced enterotoxigenic Escherichia coli diarrhea in newborn Holstein calves
PubMed ID: 26298758
Antisecretory agent improved fecal dry matter in calves with ETEC diarrhea (relates to stool consistency).
- Effect of bovine colostrum feeding in comparison with milk replacer and natural feeding on the immune responses and colonisation of enterotoxigenic Escherichia coli in the intestinal tissue of piglets
PubMed ID: 25743486
Bovine colostrum reduced E. coli colonization and diarrhoea in piglets (clear improvement in stool outcomes).
- Effect of bovine colostrum intake on growth, reproductive parameters and survival in red kids
PubMed ID: 25356485
Goat-kid trial: small daily bovine colostrum doses increased growth and markedly reduced mortality, consistent with improved gut-related resilience.
- A randomized controlled trial on preweaning morbidity, growth and mortality in Holstein heifers fed a lacteal-derived colostrum replacer or pooled maternal colostrum
PubMed ID: 23965249
Large calf RCT: colostrum replacer reduced diarrhea incidence and antibiotic treatments vs low-quality pooled maternal colostrum.
- Heat-treated colostrum and reduced morbidity in preweaned dairy calves: results of a randomized trial and examination of mechanisms of effectiveness
PubMed ID: 22720957
Heatâtreated colostrum in calves reduced scours incidence and morbidity vs fresh colostrum.
- Improvement of growth performance and sanitary status of weaned piglets fed a bovine colostrum-supplemented diet
PubMed ID: 22079995
Large piglet trials: bovine colostrum reduced postweaning diarrhoea and improved fecal consistency.
- Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers
PubMed ID: 21526980
Strong human ETEC challenge RCT: hyperimmune bovine colostrum dramatically reduced incidence/severity of diarrhoea.
- Effect of bovine colostrum-based food supplement in the treatment of HIV-associated diarrhea in Northern Uganda: a randomized controlled trial
PubMed ID: 22161540
RCT in HIV patients: colostrum supplement greatly reduced daily stool frequency and fatigue.
- A randomized, double-blind study comparing Clostridium difficile immune whey and metronidazole for recurrent Clostridium difficile-associated diarrhoea: efficacy and safety data of a prematurely interrupted trial
PubMed ID: 19086244
Human RCT: colostrum-derived C. difficile immune whey gave clinical responses similar to metronidazole for recurrent C. difficile, indicating symptomatic/gut benefit.
- Efficacy of an infant formula containing anti-Escherichia coli colostral antibodies from hyperimmunized cows in preventing diarrhea in infants and children: a field trial
PubMed ID: 12839713
Infant RCT: formula with bovine colostral antibodies reduced diarrhea incidence and duration and improved weight gainâdirect evidence of digestive symptom benefit.
- Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum
PubMed ID: 9877365
Doubleâblind RCT: oral immunoglobulins reduced stool output/frequency and sped rotavirus clearance.
- Hyperimmune cow colostrum reduces diarrhoea due to rotavirus: a double-blind, controlled clinical trial
PubMed ID: 8652974
RCT in children: hyperimmune colostrum shortened rotavirus diarrhea duration and reduced stool output.
- The Effect of Swaddling and Oropharyngeal Colostrum During Endotracheal Suctioning on Procedural Pain and Comfort in Premature Neonates: A Randomized Controlled Trial
PubMed ID: 39141691
Oropharyngeal colostrum improved postâprocedure comfort in intubated preterm neonates (reduced distress after suctioning).
- A Randomized, Controlled Study to Investigate How Bovine Colostrum Fortification of Human Milk Affects Bowel Habits in Preterm Infants (FortiColos Study)
PubMed ID: 36432444
RCTS in very preterm infants showed softer stools, improved abdominal scores and later laxative need with bovine colostrum fortifier.
- Therapeutic interventions targeting enteropathy in severe acute malnutrition modulate systemic and vascular inflammation and epithelial regeneration
PubMed ID: 39662176
Increased intestinal repair markers and reduced endotoxin in malnourished children imply improved gut/comfort.
- Does oral care with mother's colostrum reduce the risk of late-onset sepsis in preterm infants? A randomized clinical trial
PubMed ID: 39973530
Oropharyngeal colostrum sped feeding start and reduced infections, suggesting better early digestive tolerance.
- Investigating the effect of oropharyngeal colostrum in the prevention of late-onset sepsis in preterm infants: a randomized controlled trial
PubMed ID: 40389508
Trend to less clinical sepsis and significantly earlier full enteral feeding in preterm infants.
- The Effect of Oral Immunotherapy on Preterm Neonates: A Promising Adjuvant Therapy in a Clinical Trial Study
PubMed ID: 40690903
Oropharyngeal colostrum shortened hospital stay and sped feeding advancementâpractical digestive benefit.
- Oropharyngeal administration of colostrum for preventing necrotizing enterocolitis and late-onset sepsis in preterm infants with gestational ageââ€â32âweeks: a pilot single-center randomized controlled trial
PubMed ID: 34419090
Oropharyngeal maternal colostrum trial in preterms reduced NEC and sepsis and sped feeding (clinically relevant GI benefit).
- Post-Delivery Milking Delay Influence on the Effect of Oral Supplementation with Bovine Colostrum as Measured with Intestinal Permeability Test
PubMed ID: 32987647
Human trial: veryâearly (2h) colostrum reduced intestinal permeability (L/M), supporting improved gut barrier and comfort.
- Bovine Colostrum in the Treatment of Acute Diarrhea in Children: A Double-Blinded Randomized Controlled Trial
PubMed ID: 31168590
Doubleâblind RCT in children with acute diarrhea showing large reductions in vomiting, diarrhea frequency and severity.
Wellbeing (23)
- The Effect of Oral Immunotherapy on Preterm Neonates: A Promising Adjuvant Therapy in a Clinical Trial Study
PubMed ID: 40690903
Shorter hospital stay, earlier feeding, and lower sepsis rates translate to better overall neonatal outcomes.
- Improved physical disability and nutritional status by bovine colostrum supplementation in adults with traumatic peri-trochanteric femoral fracture: A randomized, controlled, clinical trial
PubMed ID: 38042695
Postâfemur fracture RCT showed improved appetite, weight gain, lymphocytes and modestly better physical disabilityâmeaningful wellbeing improvements.
- Oropharyngeal administration of colostrum for preventing necrotizing enterocolitis and late-onset sepsis in preterm infants with gestational ageââ€â32âweeks: a pilot single-center randomized controlled trial
PubMed ID: 34419090
Preterm trial: clinically important reductions in NEC/sepsis and faster feeding represent tangible wellbeing improvements for infants.
- Bovine Colostrum in the Treatment of Acute Diarrhea in Children: A Double-Blinded Randomized Controlled Trial
PubMed ID: 31168590
Children with acute diarrhea had reduced symptoms and severity, indicating improved shortâterm wellbeing.
- Role of Oropharyngeal Administration of Colostrum in Very Low Birth Weight Infants for Reducing Necrotizing Enterocolitis: A Randomized Controlled Trial
PubMed ID: 31087313
VLBW infant RCT: oropharyngeal colostrum shortened hospital stay (improved shortâterm wellbeing/resource use).
- Oral colostrum priming shortens hospitalization without changing the immunomicrobial milieu
PubMed ID: 27684425
Oral colostrum priming shortened neonatal hospital stay by ~2 weeksâclinically meaningful improvement in newborn outcomes and wellbeing.
- Efficacy, tolerability and safety of a new medical device, Monurelle Biogel(Âź) vaginal gel, in the treatment of vaginal dryness: a randomized clinical trial in women of reproductive age
PubMed ID: 27261817
Vaginal gel with bovine colostrum improved symptoms and sexual function in women, enhancing quality of life.
- Oropharyngeal colostrum administration in extremely premature infants: an RCT
PubMed ID: 25624376
Marked reductions in clinical sepsis and improved immune markers in extremely preterm infants given oropharyngeal colostrum â major wellbeing outcome.
- A randomized clinical trial evaluating metabolism of colostral and plasma derived immunoglobulin G in Jersey bull calves
PubMed ID: 25858814
Colostrum-fed calves had much higher IgG and lower mortality vs plasma â broad neonatal survival/wellbeing benefit.
- Effect of bovine colostrum intake on growth, reproductive parameters and survival in red kids
PubMed ID: 25356485
Improved survival and growth in goat kids implies better overall early-life wellbeing after bovine colostrum supplementation.
- Effects of bovine colostrum supplementation on upper respiratory illness in active males
PubMed ID: 24200515
Fewer respiratory illness days/episodes with bovine colostrum in active men indicates a meaningful effect on overall health/wellbeing.
- The effect of bovine colostrum supplementation in older adults during resistance training
PubMed ID: 24281841
Older adults gained more lower-body strength and had reduced bone-resorption marker versus wheyâbenefits relevant to functional wellbeing with age.
- A randomized controlled trial on preweaning morbidity, growth and mortality in Holstein heifers fed a lacteal-derived colostrum replacer or pooled maternal colostrum
PubMed ID: 23965249
Colostrum replacer improved morbidity and daily weight gain in calves, improving neonatal wellbeing metrics.
- Improvement of growth performance and sanitary status of weaned piglets fed a bovine colostrum-supplemented diet
PubMed ID: 22079995
Improved growth and reduced diarrhoea in piglets implies better general health/wellbeing for animals.
- The effect of bovine colostrum on viral upper respiratory tract infections in children with immunoglobulin A deficiency
PubMed ID: 21801330
Bovine colostrum reduced symptom severity in IgAâdeficient children â clinically relevant improvement in wellbeing.
- Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers
PubMed ID: 21526980
Prevention of ETEC illness in volunteers strongly improves acute wellbeing, given large reductions in diarrhoea and pain.
- Effect of bovine colostrum-based food supplement in the treatment of HIV-associated diarrhea in Northern Uganda: a randomized controlled trial
PubMed ID: 22161540
HIV RCT: large improvements in stool frequency, weight gain and fatigue indicate meaningful increases in overall wellbeing.
- Bovine colostrum in the management of nonorganic failure to thrive: a randomized clinical trial
PubMed ID: 20639714
Underweight children receiving bovine colostrum had better weight-for-age and higher recovery rates, reflecting improved overall clinical wellbeing.
- Effects of Varied Omega-3 Fatty Acid Supplementation on Postpartum Mental Health and the Association between Prenatal Erythrocyte Omega-3 Fatty Acid Levels and Postpartum Mental Health
PubMed ID: 37892462
Human randomized trial: perilla oil (ALA) reduced postpartum depressive symptoms â improved maternal wellbeing signal linked to colostrum fatty acids.
- Moderate Dose Bovine Colostrum Supplementation in Prevention of Upper Respiratory Tract Infections in Medical University Students: A Randomized, Triple Blind, Placebo-Controlled Trial
PubMed ID: 37111143
Medicalâstudent subgroup had improved wellâbeing alongside fewer URTI days/severity in RCT.
- Six Weeks of Supplementation with Bovine Colostrum Effectively Reduces URTIs Symptoms Frequency and Gravity for Up to 20 Weeks in Pre-School Children
PubMed ID: 37630816
Preschool trial reported reduced URTI burden and symptom severity with BC, likely improving overall wellbeing for children.
- Does oral care with mother's colostrum reduce the risk of late-onset sepsis in preterm infants? A randomized clinical trial
PubMed ID: 39973530
Lower mortality and infections and faster feeding in infants represent major wellbeing improvements.
- Therapeutic Effects of Bovine Colostrum on Bone Healing, Rehabilitation, and Postoperative Complications: A Prospective, Randomized, Double-Blinded Comparative Trial
PubMed ID: 40249794
Accelerated radiographic healing and improved function after hip fracture indicate meaningful recovery/wellbeing gains in adults.
Nutrient uptake (15)
- Effect of colostrum heat treatment and bacterial population on immunoglobulin G absorption and health of neonatal calves
PubMed ID: 25935243
Reducing bacterial contamination and heat treating colostrum improved apparent efficiency of IgG absorption (clear effect on passive transfer/absorption).
- Metabolomics reveals changes in levels of fecal branched chain amino acids and organic acids in very preterm infants fed human milk fortified with bovine colostrum
PubMed ID: 39581179
Preterm infants fed human milk fortified with bovine colostrum had altered fecal metabolome and different mineral supplement needs.
- Efficacy of an infant formula containing anti-Escherichia coli colostral antibodies from hyperimmunized cows in preventing diarrhea in infants and children: a field trial
PubMed ID: 12839713
Infant RCT: better weight gain with colostral antibodies suggests improved nutrient utilization/absorption in infants.
- Effect of enteral IGF-1 supplementation on feeding tolerance, growth, and gut permeability in enterally fed premature neonates
PubMed ID: 18223378
Enteral IGF-1 (a colostrum trophic factor) transiently improved gut permeability in very preterm infants, implying enhanced absorptive function.
- Effects of colostrum replacer supplemented with lactoferrin on the blood plasma immunoglobulin G concentration and intestinal absorption of xylose in the neonatal calf
PubMed ID: 19286825
Lactoferrin added to colostrum replacer decreased apparent efficiency of IgG absorption and altered xylose absorption in calves, showing direct effects on intestinal uptake.
- Heat-treated colostrum and reduced morbidity in preweaned dairy calves: results of a randomized trial and examination of mechanisms of effectiveness
PubMed ID: 22720957
Feeding heatâtreated colostrum increased serum IgG concentrations in calves, indicating improved passive transfer/absorption.
- Efficacy of feeding a lacteal-derived colostrum replacer or pooled maternal colostrum with a low IgG concentration for prevention of failure of passive transfer in dairy calves
PubMed ID: 23822086
Large trial: lacteal-derived colostrum replacer produced much higher serum IgG/TP and markedly reduced failure of passive transferâdirect evidence of improved macromolecule transfer/absorption in neonates.
- Heat treatment of colostrum increases immunoglobulin G absorption efficiency in high-, medium-, and low-quality colostrum
PubMed ID: 24508433
Heating colostrum reduced bacterial counts and increased apparent efficiency of IgG absorption (~21%) and 48-h IgG levels (~18%).
- Colostrum replacer feeding regimen, addition of sodium bicarbonate, and milk replacer: the combined effects on absorptive efficiency of immunoglobulin G in neonatal calves
PubMed ID: 24534514
Addition of sodium bicarbonate to colostrum replacer decreased 24-h serum IgG, AEA and AUCâclear evidence that formulation affects IgG absorption (negative effect reported).
- Effect of heat stress during late gestation on immune function and growth performance of calves: isolation of altered colostral and calf factors
PubMed ID: 25108869
Calves from heat-stressed dams had lower apparent efficiency of IgG absorption (~26.0% vs 30.2%) â maternal environment affects neonatal absorption.
- Bovine Colostrum for Preterm Infants in the First Days of Life: A Randomized Controlled Pilot Trial
PubMed ID: 29019855
Preterm infant pilot: bovine colostrum increased enteral protein intake and hastened feedingâdirect nutritional/absorption relevance.
- Post-Delivery Milking Delay Influence on the Effect of Oral Supplementation with Bovine Colostrum as Measured with Intestinal Permeability Test
PubMed ID: 32987647
Human trial: earlyâharvest colostrum reduced intestinal permeability (L/M), suggesting improved mucosal function for absorption.
- Oropharyngeal administration of colostrum for preventing necrotizing enterocolitis and late-onset sepsis in preterm infants with gestational ageââ€â32âweeks: a pilot single-center randomized controlled trial
PubMed ID: 34419090
Faster progression to full enteral feeds in preterms suggests improved feeding tolerance and nutrient delivery.
- Bovine colostrum as a fortifier to human milk in very preterm infants - A randomized controlled trial (FortiColos)
PubMed ID: 37004355
BC fortifier raised plasma amino acids and provided more proteinâdirect evidence of altered nutrient provision/absorption.
- Glucose-regulatory hormones and growth in very preterm infants fed fortified human milk
PubMed ID: 38580842
Incretin and IGFâ1 increases with BC fortifier correlated with early weight/length growthâphysiologic evidence affecting nutrient handling.
Weight management (11)
- Effect of bovine colostrum intake on growth, reproductive parameters and survival in red kids
PubMed ID: 25356485
Goat-kid trial: bovine colostrum supplementation produced sustained higher growth rates and markedly lower mortality.
- Bovine colostrum in the management of nonorganic failure to thrive: a randomized clinical trial
PubMed ID: 20639714
Human RCT: three months of bovine colostrum supplementation improved weight-for-age (Gomez index) and clinical recovery in underweight children.
- Effect of bovine colostrum-based food supplement in the treatment of HIV-associated diarrhea in Northern Uganda: a randomized controlled trial
PubMed ID: 22161540
HIV RCT: colostrum supplement produced substantial body weight/BMI increases in patients with wasting.
- Improvement of growth performance and sanitary status of weaned piglets fed a bovine colostrum-supplemented diet
PubMed ID: 22079995
Piglet trials: colostrum improved average daily gain and growthârelevant to weight gain/management in developing animals.
- Effect of dietary supplementation with glycitein during late pregnancy and lactation on antioxidative indices and performance of primiparous sows
PubMed ID: 26020321
Sow glycitein increased milk antioxidant activity and improved piglet ADG and weaned BW (~10% higher) â influence on growth/weight.
- A randomized controlled trial on preweaning morbidity, growth and mortality in Holstein heifers fed a lacteal-derived colostrum replacer or pooled maternal colostrum
PubMed ID: 23965249
Colostrum replacer produced slightly higher daily weight gain (+~0.05 kg/d) in calves versus low-quality pooled maternal colostrum.
- Glucose-regulatory hormones and growth in very preterm infants fed fortified human milk
PubMed ID: 38580842
Incretin and IGFâ1 changes with BC fortifier correlated with early weight/length gains.
- Do preterm infants' retinas like bovine colostrum? A randomized controlled trial
PubMed ID: 39427215
Preterm infant RCT (smallâdose BC) improved early weight gain compared with control.
- Improved physical disability and nutritional status by bovine colostrum supplementation in adults with traumatic peri-trochanteric femoral fracture: A randomized, controlled, clinical trial
PubMed ID: 38042695
Postâop adult RCT: colostrum accelerated weight gain and improved appetite and nutritional labs vs control protein.
- Bovine colostrum as a fortifier to human milk in very preterm infants - A randomized controlled trial (FortiColos)
PubMed ID: 37004355
BC fortifier provided slightly more protein and produced similar growth but altered plasma amino acidsârelevant to weight/nutrition.
- The effect of bovine colostrum/egg supplementation compared with corn/soy flour in young Malawian children: a randomized, controlled clinical trial
PubMed ID: 33330913
Malawian infant trial showed modest increased LAZ and reduced stunting prevalence with BC+egg.
Inflammation (10)
- Enteral application of an immunoglobulin-enriched colostrum milk preparation for reducing endotoxin translocation and acute phase response in patients undergoing coronary bypass surgery--a randomized placebo-controlled pilot trial
PubMed ID: 12528325
Preâop colostrum reduced postoperative CRP (inflammatory marker)
- Therapeutic interventions targeting enteropathy in severe acute malnutrition modulate systemic and vascular inflammation and epithelial regeneration
PubMed ID: 39662176
Lower endotoxin levels and markers of gut repair indicate reduced systemic inflammation in severely malnourished children.
- Malnutrition enteropathy in Zambian and Zimbabwean children with severe acute malnutrition: A multi-arm randomized phase II trial
PubMed ID: 38632262
In children with severe malnutrition, colostrum reduced plasma CRP and increased crypt depthâdirect antiâinflammatory and mucosal effects.
- Do preterm infants' retinas like bovine colostrum? A randomized controlled trial
PubMed ID: 39427215
Preterm smallâdose BC reduced CRP and was associated with fewer ROP eventsâmarker of reduced systemic inflammation.
- Improved physical disability and nutritional status by bovine colostrum supplementation in adults with traumatic peri-trochanteric femoral fracture: A randomized, controlled, clinical trial
PubMed ID: 38042695
Postâoperative trial reported improved lab markers including albumin, hemoglobin and lymphocytes and implied improved inflammatory/nutritional status.
- Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A randomized, double-blind, placebo-controlled study
PubMed ID: 30551120
ICU RCT: reductions in endotoxin and zonulin imply lowered systemic inflammatory stimulus from gut translocation.
- Effect of dietary supplementation with glycitein during late pregnancy and lactation on antioxidative indices and performance of primiparous sows
PubMed ID: 26020321
Glycitein supplementation lowered milk MDA and raised antioxidant enzymes, suggesting reduced oxidative/inflammatory stress in piglets.
- Oropharyngeal colostrum administration in extremely premature infants: an RCT
PubMed ID: 25624376
Oropharyngeal colostrum reduced proâinflammatory salivary markers and clinical sepsis in preterms (antiâinflammatory signal).
- The effect of bovine colostrum supplementation in older adults during resistance training
PubMed ID: 24281841
Older adults on bovine colostrum showed reduced urinary Nâtelopeptides (marker of bone resorption), an inflammation/turnover-related marker.
- Immunomodulatory effects of the intake of fermented milk with Lactobacillus casei DN114001 in lactating mothers and their children
PubMed ID: 18341756
Maternal consumption of L. casei fermented milk decreased TNF-α in milk, indicating an anti-inflammatory change in breast/colostrum immunology.
Allergy relief (5)
- Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study
PubMed ID: 18477013
Maternal probiotic during pregnancy/lactation lowered allergy sensitization risk in high-risk infants and altered colostrum cytokines (RCT evidence).
- High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented mothers are related to less immunoglobulin E-associated disease in infancy
PubMed ID: 26970335
Human randomized maternal supplementation: higher colostrum EPA/DHA associated with fewer infant IgEâassociated allergic diseases.
- Impact of maternal allergy and use of probiotics during pregnancy on breast milk cytokines and food antibodies and development of allergy in children until 5 years
PubMed ID: 22652586
Maternal allergy and probiotic use modified immune components in colostrum/milk that associated with child allergy risk (human cohort evidence).
- Breast-feeding and the development of cows' milk protein allergy
PubMed ID: 11065065
Lower maternal colostral TGFâÎČ1 associated with higher infant IgEâmediated cow'sâmilk allergy risk (direct allergy link)
- Low breast milk TGF-beta2 is induced by Lactobacillus reuteri supplementation and associates with reduced risk of sensitization during infancy
PubMed ID: 18221472
Maternal L. reuteri supplementation altered colostrum TGF-ÎČ2 and was associated with reduced infant sensitization, indicating improved allergy resilience.
Tissue repair (9)
- Oral colostrum priming shortens hospitalization without changing the immunomicrobial milieu
PubMed ID: 27684425
Oral colostrum priming in very preterm infants shortened hospital stay by ~16 days â clinically meaningful faster recovery/health stabilization.
- Improved physical disability and nutritional status by bovine colostrum supplementation in adults with traumatic peri-trochanteric femoral fracture: A randomized, controlled, clinical trial
PubMed ID: 38042695
Postâfemur fracture RCT showed accelerated weight gain, improved nutrition labs and modestly better physical disabilityâindicative of faster functional recovery/healing.
- Malnutrition enteropathy in Zambian and Zimbabwean children with severe acute malnutrition: A multi-arm randomized phase II trial
PubMed ID: 38632262
Increased crypt depth and reduced inflammation in malnourished children support faster mucosal healing.
- Does oral care with mother's colostrum reduce the risk of late-onset sepsis in preterm infants? A randomized clinical trial
PubMed ID: 39973530
Faster initiation of enteral feeding and large reductions in sepsis/mortality indicate more rapid clinical recovery in infants.
- Therapeutic Effects of Bovine Colostrum on Bone Healing, Rehabilitation, and Postoperative Complications: A Prospective, Randomized, Double-Blinded Comparative Trial
PubMed ID: 40249794
Randomized trial demonstrated accelerated radiographic bone healing and faster functional recovery with bovine colostrum after hip fracture.
- The Effect of Oral Immunotherapy on Preterm Neonates: A Promising Adjuvant Therapy in a Clinical Trial Study
PubMed ID: 40690903
Shorter hospital stays and accelerated feeding/fullenteral intake suggest faster clinical recovery in preterm infants receiving oropharyngeal colostrum.
- Oropharyngeal administration of colostrum for preventing necrotizing enterocolitis and late-onset sepsis in preterm infants with gestational ageââ€â32âweeks: a pilot single-center randomized controlled trial
PubMed ID: 34419090
Oropharyngeal maternal colostrum shortened time to full enteral feeding and reduced NEC/sepsisâsignals of faster clinical recovery in preterms.
- Effects of epidermal growth factor on atrophic enteritis in piglets induced by experimental porcine epidemic diarrhoea virus
PubMed ID: 17574457
EGF-treated piglets exhibited faster mucosal healing and increased crypt proliferation after viral enteritis; EGF is enriched in colostrum.
- A randomized clinical trial evaluating metabolism of colostral and plasma derived immunoglobulin G in Jersey bull calves
PubMed ID: 25858814
Colostrum feeding reduced mortality in calves vs plasma and yielded prolonged IgG presence, implying faster recovery/clinical resilience.
Exercise recovery (5)
- IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training
PubMed ID: 12133885
Raised serum IGFâI after colostrum â plausible anabolic/recovery mediator
- Impact of differing protein sources and a creatine containing nutritional formula after 12 weeks of resistance training
PubMed ID: 17679046
Resistanceâtraining trial showed greater leanâmass gains with colostrum (esp. with creatine) â relevant to muscle adaptation/recovery.
- Bovine colostrum supplementation during endurance running training improves recovery, but not performance
PubMed ID: 12188088
Improved secondâbout running performance indicates better recovery capacity
- The effect of bovine colostrum supplementation in older adults during resistance training
PubMed ID: 24281841
Older adults doing resistance training achieved greater leg-press strength gains with bovine colostrum vs wheyâconsistent with enhanced adaptation/recovery.
- Therapeutic Effects of Bovine Colostrum on Bone Healing, Rehabilitation, and Postoperative Complications: A Prospective, Randomized, Double-Blinded Comparative Trial
PubMed ID: 40249794
Improved short-term functional recovery after hip fracture suggests benefits to musculoskeletal recovery.
Workout performance (5)
- The effect of bovine colostrum supplementation in older adults during resistance training
PubMed ID: 24281841
Resistance-trained older adults had larger leg-press strength improvements with bovine colostrum â relevant to performance in strength tasks.
- Impact of differing protein sources and a creatine containing nutritional formula after 12 weeks of resistance training
PubMed ID: 17679046
Leanâmass increases occurred with colostrum in resistanceâtraining context; strength gains were not different but body composition changed.
- The effect of bovine colostrum supplementation on exercise performance in elite field hockey players
PubMed ID: 12500989
Eightâweek colostrum improved 5Ă10 m sprint times in elite athletes (clear performance gain)
- Dose effects of oral bovine colostrum on physical work capacity in cyclists
PubMed ID: 12131260
Timeâtrial improvements after prolonged cycling indicate endurance performance benefit
- Effect of bovine colostrum on anaerobic exercise performance and plasma insulin-like growth factor I
PubMed ID: 12848392
Slight increase in peak anaerobic power with colostrum vs whey (anaerobic performance)
Oral health (4)
- Oral hygiene grade and quality of life in children with chemotherapy-related oral mucositis: a randomized study on the impact of a fluoride toothpaste with salivary enzymes, essential oils, proteins and colostrum extract versus a fluoride toothpaste without menthol
PubMed ID: 27160933
Randomized human study: toothpaste containing colostrum extract improved oral hygiene index in chemo patients.
- The Effect of Oral Colostrum Application on the Condition of the Mouth and Incidence of Late-Onset Sepsis Among Premature Infants: A Randomized Controlled Trial
PubMed ID: 39141690
Topical/oral maternal colostrum improved mouth condition and reduced required oral care in preterm infants.
- Long Duration of Oral Care Using Mother's Own Milk Influences Oral Microbiota and Clinical Outcomes in Very-low-birthweight Infants: Randomized Controlled Trial
PubMed ID: 37343216
Prolonged oropharyngeal motherâs milk preserved healthy oral bacteria and reduced clinical sepsis in VLBW infantsâstrong oral microbiota/clinical benefit.
- Bovine Colostrum Against Chemotherapy-Induced Gastrointestinal Toxicity in Children With Acute Lymphoblastic Leukemia: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 30861163
RCT in children with ALL: bovine colostrum substantially reduced peak severity of oral mucositis (clear oralâhealth benefit).
Energy & Fatigue (2)
- Effect of bovine colostrum-based food supplement in the treatment of HIV-associated diarrhea in Northern Uganda: a randomized controlled trial
PubMed ID: 22161540
Significant reductions in fatigue and weight gain in HIV patients indicate improved energy/functional status.
- Improved physical disability and nutritional status by bovine colostrum supplementation in adults with traumatic peri-trochanteric femoral fracture: A randomized, controlled, clinical trial
PubMed ID: 38042695
Improved appetite, weight gain and functional disability suggest increased energy/functional capacity postâsurgery.
Bone health (2)
- The effect of bovine colostrum supplementation in older adults during resistance training
PubMed ID: 24281841
Human RCT in older adults: bovine colostrum led to larger leg-press strength gains and reduced urinary Nâtelopeptides (bone resorption marker) versus whey.
- Therapeutic Effects of Bovine Colostrum on Bone Healing, Rehabilitation, and Postoperative Complications: A Prospective, Randomized, Double-Blinded Comparative Trial
PubMed ID: 40249794
Randomized trial after hip fracture showed accelerated radiographic healing (RUSH) and better functional scores with bovine colostrum vs whey.
Mental clarity (2)
- Colostrinin: a proline-rich polypeptide (PRP) complex isolated from ovine colostrum for treatment of Alzheimer's disease. A double-blind, placebo-controlled study
PubMed ID: 10608295
Ovine colostrumâderived Colostrinin improved or stabilized cognition in a yearâlong pilot Alzheimer trial.
- Colostrinin (a naturally occurring, proline-rich, polypeptide mixture) in the treatment of Alzheimer's disease
PubMed ID: 15004324
Randomized trial in mildâmoderate Alzheimer's: Colostrinin produced modest early cognitive and functional improvements/stabilization.
Healthy aging (2)
- Colostrinin: a proline-rich polypeptide (PRP) complex isolated from ovine colostrum for treatment of Alzheimer's disease. A double-blind, placebo-controlled study
PubMed ID: 10608295
Colostrinin improved or stabilized cognition in some mildâtoâmoderate Alzheimer patients (pilot evidence for ageârelated cognitive support).
- The effect of bovine colostrum supplementation in older adults during resistance training
PubMed ID: 24281841
Human randomized double-blind study in older adults: bovine colostrum produced greater strength gains and reduced bone-resorption marker versus wheyâdirect relevance to functional aging support.
Skin health (1)
- Effect of bovine colostrum supplementation on the composition of resistance trained and untrained limbs in healthy young men
PubMed ID: 14504943
Human RCT found localized increases in limb CSA driven by skin/subcutaneous tissue rather than muscle after colostrum during training.
Similar by evidence
Supplements the same benefits carry qualifying findings for â a fact about the evidence graph, not a recommendation to swap.
Products with Colostrum
Search all228 products whose verified label declares Colostrum â not every bottle that mentions it in a title.