Pomegranate
16 benefits mapped to clinical evidence across supplements.
Dose per serving from products
556 products in our catalogue print how much Pomegranate a serving holds.
Most common: 500 mg to 1 g, 28% of 556 products.
| Dose per serving | Products |
|---|---|
| 10 mg or less | 21 |
| 10 mg to 25 mg | 66 |
| 25 mg to 50 mg | 77 |
| 50 mg to 100 mg | 91 |
| 100 mg to 250 mg | 79 |
| 250 mg to 500 mg | 58 |
| 500 mg to 1 g | 157 |
| over 1 g | 7 |
Dose per serving from research
44 study groups in 37 studies say how much Pomegranate participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mg to 1 g, 48% of 44 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mg or less | 2 |
| 100 mg to 250 mg | 4 |
| 250 mg to 500 mg | 10 |
| 500 mg to 1 g | 21 |
| 1 g to 2.5 g | 3 |
| 2.5 g to 5 g | 1 |
| 5 g to 10 g | 1 |
| over 10 g | 2 |
Benefit Evidence
Hydration/elasticity +brightness
Sunburn resistance +34.7
Lightening/smoothness +reduced pigmentation
Cortisol ↓; T4 no change
Menopause symptoms/QoL improved
PMS symptoms/social QoL improved
Hydration/elasticity +brightness
Sunburn resistance +34.7
Lightening/smoothness +reduced pigmentation
Cortisol ↓; T4 no change
Menopause symptoms/QoL improved
PMS symptoms/social QoL improved
Research sources
Heart health (23)
- Does Pomegranate intake attenuate cardiovascular risk factors in hemodialysis patients?
PubMed ID: 24593225
One-year trial in hemodialysis patients demonstrated clinically meaningful BP lowering and improved HDL/TG in those with baseline abnormalities.
- Effects of pomegranate juice supplementation on pulse wave velocity and blood pressure in healthy young and middle-aged men and women
PubMed ID: 22648092
Four-week pomegranate juice produced modest but significant reductions in systolic and diastolic blood pressure in healthy adults.
- One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: a randomized placebo-controlled trial
PubMed ID: 22609423
One-year hemodialysis trial showed slowed atherosclerotic progression and improved oxidative/inflammatory markers relevant to cardiovascular risk.
- Acute and long-term effects of grape and pomegranate juice consumption on vascular reactivity in paediatric metabolic syndrome
PubMed ID: 20170591
Improved flow-mediated dilation (endothelial function) in adolescents with metabolic syndrome after acute and 1-month pomegranate juice intake.
- Precision health targeting TMAO in postmenopausal women: polyphenol effects modulated by urolithin A and equol metabotypes in a randomised, placebo-controlled crossover trial
PubMed ID: 41642121
A polyphenol blend including pomegranate reduced urinary TMAO/DMA (atherogenesis-linked metabolites) in postmenopausal women (metabotype-dependent).
- Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55-70 Years: A Randomised Controlled Parallel Trial
PubMed ID: 40218993
Pomegranate extract lowered systolic blood pressure (~5 mmHg) in older adults, supporting cardiovascular benefit.
- Pomegranate (Punica granatum L.) peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trial
PubMed ID: 37605174
Pomegranate peel extract reduced LDL-C and improved liver stiffness/weight in NAFLD—beneficial cardiometabolic effects.
- Quantification of Local Vessel Wall and Plaque Volume Change for Assessment of Effects of Therapies on Carotid Atherosclerosis Based on 3-D Ultrasound Imaging
PubMed ID: 36566092
Voxel-level 3-D ultrasound showed significantly less carotid vessel-wall/plaque volume change with pomegranate therapy (anti-atherosclerotic imaging evidence).
- Three-dimensional ultrasound assessment of effects of therapies on carotid atherosclerosis using vessel wall thickness maps
PubMed ID: 34148714
3-D carotid thickness mapping detected significantly different (less) plaque/thickness change with pomegranate therapy.
- Effect of Pomegranate Peel Consumption on Liver Enzymes, Lipid Profile, Liver Steatosis, and Hs-CRP in Patients With Non-alcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
PubMed ID: 39608758
NAFLD RCT showed improved triglycerides and HDL, which are relevant to heart health.
- Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease
PubMed ID: 16169367
RCT in coronary disease showed reduced stress‑induced myocardial ischemia after pomegranate juice—direct cardiac benefit.
- The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications
PubMed ID: 19834314
Polyphenol supplement including pomegranate improved LDL/HDL and oxidative stress in T2D—cardiometabolic benefits.
- Effects of pomegranate peel extract and vitamin E on the inflammatory status and endothelial function in hemodialysis patients: a randomized controlled clinical trial
PubMed ID: 32839797
Lowered endothelial dysfunction markers (ICAM-1, VCAM-1) and reduced inflammatory biomarkers support vascular/heart health.
- Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial
PubMed ID: 20334708
Pomegranate seed oil for 4 weeks reduced triglycerides and improved lipid ratios in hyperlipidemic subjects.
- The effect of pomegranate extract on anthropometric indices, serum lipids, glycemic indicators, and blood pressure in patients with nonalcoholic fatty liver disease: A randomized double-blind clinical trial
PubMed ID: 34498307
In NAFLD patients, pomegranate extract lowered total cholesterol and triglycerides and raised HDL—favorable cardiovascular risk changes.
- The effect of concentrated pomegranate juice consumption on risk factors of cardiovascular diseases in women with polycystic ovary syndrome: A randomized controlled trial
PubMed ID: 32767710
Concentrated PJ in PCOS lowered BP and TG and raised HDL (favorable cardiometabolic profile, though LDL rose slightly).
- Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial
PubMed ID: 31646650
PJ during dialysis improved BP, TG/HDL and lowered oxidative/inflammatory markers (consistent cardiometabolic improvements in clinical population).
- Effects of pomegranate juice consumption on blood pressure and lipid profile in patients with type 2 diabetes: A single-blind randomized clinical trial
PubMed ID: 30661697
6‑week RCT in T2D produced clinically meaningful reductions in systolic and diastolic BP (blood‑pressure benefit supports cardiac risk reduction).
- Cardioprotective Effects of Pomegranate (Punica granatum) Juice in Patients with Ischemic Heart Disease
PubMed ID: 28913846
Inpatients with unstable angina/MI had reduced angina and lower troponin and oxidative stress over hospitalization (acute cardiac benefit alongside standard care).
- Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomized clinical trial
PubMed ID: 27879044
Dose‑response trial showed large, dose‑dependent LDL/total cholesterol and oxidized‑LDL reductions in a specific gut‑metabotype (strong cardiometabolic lipid effects).
- Effects of Pomegranate Juice on Cardiovascular Risk Factors in Patients with Metabolic Syndrome: a Double-Blinded, Randomized Crossover Controlled Trial
PubMed ID: 28303364
One‑week crossover in metabolic syndrome acutely lowered systolic/diastolic BP (short‑term hemodynamic benefit).
- Effects of pomegranate juice consumption on oxidative stress in patients with type 2 diabetes: a single-blind, randomized clinical trial
PubMed ID: 27633135
In T2D, PJ reduced oxidized LDL and increased total antioxidant capacity—changes relevant to atherosclerotic risk.
- Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: A randomized controlled clinical trial
PubMed ID: 26850805
30‑day RCT lowered LDL‑C in overweight/obese adults (direct favorable lipid change).
Antioxidant (18)
- Effects of Pomegranate Extract Supplementation on Cardiovascular Risk Factors and Physical Function in Hemodialysis Patients
PubMed ID: 25826143
Hemodialysis trial increased paraoxonase‑1 activity (+26.6%), an antioxidant enzyme linked to cardiovascular protection.
- Cardioprotective Effects of Pomegranate (Punica granatum) Juice in Patients with Ischemic Heart Disease
PubMed ID: 28913846
Hospitalized cardiac patients had lower malondialdehyde (oxidative stress marker) after daily PJ (acute antioxidant effect).
- Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial
PubMed ID: 31646650
PJ during dialysis increased total antioxidant capacity and decreased MDA (lipid peroxidation), indicating antioxidant activity in patients.
- A phase II randomized placebo-controlled trial of pomegranate fruit extract in men with localized prostate cancer undergoing active surveillance
PubMed ID: 33095939
1‑year PFE in prostate cancer AS reduced tumor tissue 8‑OHdG (oxidative DNA damage) and AR expression (target‑tissue antioxidant effect).
- Effects of pomegranate juice in circulating parameters, cytokines, and oxidative stress markers in endurance-based athletes: A randomized controlled trial
PubMed ID: 26778544
Twenty-one-day trial in endurance athletes blunted exercise-induced increases in oxidative stress markers (MDA, protein carbonyls).
- A double-blind, randomized, neoadjuvant study of the tissue effects of POMx pills in men with prostate cancer before radical prostatectomy
PubMed ID: 23985577
Pre-surgical POMx produced detectable prostate metabolites and trends toward reduced oxidative DNA damage in prostate tissue.
- One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: a randomized placebo-controlled trial
PubMed ID: 22609423
Year-long hemodialysis RCT showed sustained reductions in multiple oxidative-stress biomarkers.
- Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size
PubMed ID: 17966977
Ellagitannin-enriched extract reduced plasma lipid-peroxidation marker (TBARS) in overweight adults (pilot data).
- Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in Rheumatoid Arthritis patients
PubMed ID: 27577177
RA trial increased GPx and reduced inflammatory markers, supporting antioxidant and inflammation-related benefits.
- Three week dietary intervention using apricots, pomegranate juice or/and fermented sour sobya and impact on biomarkers of antioxidative activity, oxidative stress and erythrocytic glutathione transferase activity among adults
PubMed ID: 27175476
Three-week RCT showed large increases in plasma antioxidant capacity and marked reductions in urinary TBARS—strong direct antioxidant evidence.
- Effects of pomegranate peel extract and vitamin E on the inflammatory status and endothelial function in hemodialysis patients: a randomized controlled clinical trial
PubMed ID: 32839797
Pomegranate peel lowered systemic inflammatory and some oxidative markers in hemodialysis patients, consistent with antioxidant effects.
- A prospective, randomized, double-blind, placebo-controlled trial of polyphenols on the outcomes of inflammatory factors and oxidative stress in patients with type 2 diabetes mellitus
PubMed ID: 35229548
Pomegranate peel extract reduced TBARS and increased TAC in T2D—strong human antioxidant evidence.
- The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications
PubMed ID: 19834314
Polyphenol supplement including pomegranate reduced MDA and raised antioxidant capacity in T2D patients.
- A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial
PubMed ID: 37685975
Lowered methylglyoxal (carbonyl stress marker), consistent with reduced oxidative/carbonyl stress.
- The Effect of a Citrus and Pomegranate Complex on Physical Fitness and Mental Well-Being in Healthy Elderly: A Randomized Placebo-Controlled Trial
PubMed ID: 36156675
Citrus+pomegranate complex decreased MDA (oxidative stress marker) in older adults.
- Pomegranate extract mouth rinsing effects on saliva measures relevant to gingivitis risk
PubMed ID: 19170139
Pomegranate mouth rinse increased salivary antioxidant capacity—local antioxidant effect.
- Effectiveness of the pomegranate extract in improving hepatokines and serum biomarkers of non-alcoholic fatty liver disease: A randomized double blind clinical trial
PubMed ID: 36535123
NAFLD RCT showed a clear increase in total antioxidant capacity versus placebo.
- Effects of pomegranate juice consumption on oxidative stress in patients with type 2 diabetes: a single-blind, randomized clinical trial
PubMed ID: 27633135
6‑week RCT in T2D showed significant reductions in oxidized LDL and increases in total antioxidant capacity and paraoxonase activity (strong antioxidant biomarker evidence).
Inflammation (17)
- Effect of Pomegranate Peel Consumption on Liver Enzymes, Lipid Profile, Liver Steatosis, and Hs-CRP in Patients With Non-alcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
PubMed ID: 39608758
NAFLD RCT reported decreased hs‑CRP and improved metabolic/inflammatory markers with pomegranate peel capsules.
- A prospective, randomized, double-blind, placebo-controlled trial of polyphenols on the outcomes of inflammatory factors and oxidative stress in patients with type 2 diabetes mellitus
PubMed ID: 35229548
Pomegranate peel extract RCT in T2D showed significant reductions in IL‑6, TNF‑α and hs‑CRP—strong evidence for anti‑inflammatory effects.
- Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55-70 Years: A Randomised Controlled Parallel Trial
PubMed ID: 40218993
12-week pomegranate extract in older adults produced a large IL-6 reduction (robust anti-inflammatory signal).
- The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis
PubMed ID: 26804926
Knee OA trial showed decreased WOMAC scores and reduced MMP-13 alongside increased GPx, supporting an anti-inflammatory/chondroprotective role.
- Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in Rheumatoid Arthritis patients
PubMed ID: 27577177
RA RCT produced large reductions in DAS28 and ESR, demonstrating clear modulation of pathologic inflammation.
- One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: a randomized placebo-controlled trial
PubMed ID: 22609423
Long trial in hemodialysis patients reduced multiple inflammation biomarkers over one year.
- Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: A randomized controlled clinical trial
PubMed ID: 26850805
30‑day RCT decreased hs‑CRP in overweight/obese adults (systemic inflammatory marker decline).
- Effects of Pomegranate Juice on Cardiovascular Risk Factors in Patients with Metabolic Syndrome: a Double-Blinded, Randomized Crossover Controlled Trial
PubMed ID: 28303364
One‑week PJ lowered hs‑CRP in metabolic syndrome population (acute anti‑inflammatory signal).
- Pomegranate Juice Increases Sirtuin1 Protein in Peripheral Blood Mononuclear Cell from Patients with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trial
PubMed ID: 29957104
12‑week RCT reduced NF‑κB and increased SIRT1 in PBMCs and lowered sE‑selectin (clear anti‑inflammatory and endothelial inflammation effects).
- The Endotoxemia Marker Lipopolysaccharide-Binding Protein is Reduced in Overweight-Obese Subjects Consuming Pomegranate Extract by Modulating the Gut Microbiota: A Randomized Clinical Trial
PubMed ID: 29665619
High‑dose PE reduced LBP and trended to lower hs‑CRP while shifting microbiota toward anti‑inflammatory taxa (gut‑mediated inflammation reduction).
- Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial
PubMed ID: 31646650
PJ during dialysis decreased IL‑6 and MDA and increased TAC—robust anti‑inflammatory/oxidative change in clinical setting.
- Clinical Efficacy of Subgingivally Delivered Punica Granatum Chip and Gel in Management of Chronic Periodontitis Patients
PubMed ID: 34158437
Local periodontal delivery of pomegranate reduced gingival inflammation and pocket depth versus scaling alone (local anti-inflammatory effect).
- Pharmacological Therapy Determines the Gut Microbiota Modulation by a Pomegranate Extract Nutraceutical in Metabolic Syndrome: A Randomized Clinical Trial
PubMed ID: 33458928
Modulation of gut microbiota with decreases in LBP and sICAM-1 in subgroups suggests anti-inflammatory effects.
- Adjuvant pomegranate juice intake improves the inflammatory status of hospitalized COVID-19 patients: A randomized and placebo-controlled trial
PubMed ID: 37271189
Hospitalized COVID-19 RCT showed significant reductions in IL-6 and CRP with pomegranate juice (strong anti-inflammatory evidence).
- Pomegranate (Punica granatum L.) peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trial
PubMed ID: 37605174
Pomegranate peel extract decreased liver stiffness and inflammatory/fibrotic markers in NAFLD—consistent with inflammation reduction.
- Effectiveness of the pomegranate extract in improving hepatokines and serum biomarkers of non-alcoholic fatty liver disease: A randomized double blind clinical trial
PubMed ID: 36535123
NAFLD RCT showed lowered liver enzymes and increased antioxidant capacity, suggesting reduced inflammatory/oxidative stress.
- Effects of pomegranate peel extract and vitamin E on the inflammatory status and endothelial function in hemodialysis patients: a randomized controlled clinical trial
PubMed ID: 32839797
Pomegranate peel extract (±vitamin E) substantially reduced CRP, IL-6 and TNF-α in hemodialysis patients—strong anti-inflammatory evidence.
Metabolism (13)
- The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications
PubMed ID: 19834314
Polyphenol supplement including pomegranate improved LDL/HDL and oxidative stress markers in T2D—strong metabolic improvement (multi‑ingredient).
- Effect of Pomegranate Peel Consumption on Liver Enzymes, Lipid Profile, Liver Steatosis, and Hs-CRP in Patients With Non-alcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
PubMed ID: 39608758
Improved triglycerides, HDL and liver enzymes in NAFLD indicates metabolic benefits.
- A prospective, randomized, double-blind, placebo-controlled trial of polyphenols on the outcomes of inflammatory factors and oxidative stress in patients with type 2 diabetes mellitus
PubMed ID: 35229548
Pomegranate peel improved lipid profile and oxidative stress in T2D—supports metabolic health.
- The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat
PubMed ID: 19840063
Xanthigen product (contains pomegranate seed oil) promoted weight loss and increased REE; multi-ingredient product limits attribution but metabolic outcomes were robust.
- Effect of synbiotic pomegranate juice on glycemic, sex hormone profile and anthropometric indices in PCOS: A randomized, triple blind, controlled trial
PubMed ID: 30538082
12-week synbiotic pomegranate juice in PCOS improved insulin resistance, lowered insulin/testosterone and reduced BMI/waist, directly supporting metabolic benefits.
- Fresh pomegranate juice ameliorates insulin resistance, enhances β-cell function, and decreases fasting serum glucose in type 2 diabetic patients
PubMed ID: 25223711
Single fresh pomegranate juice dose acutely lowered glucose and improved insulin resistance and β-cell function at 3 hours in people with type 2 diabetes.
- Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: A randomized controlled clinical trial
PubMed ID: 26850805
30‑day RCT reduced fasting glucose in overweight/obese adults (improved glycemic marker).
- Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomized clinical trial
PubMed ID: 27879044
UM‑B subgroup had large lipid improvements (cholesterol/LDL) after PE—metabolic phenotype‑dependent lipid benefits.
- Effect of pomegranate seed oil supplementation on the GLUT-4 gene expression and glycemic control in obese people with type 2 diabetes: A randomized controlled clinical trial
PubMed ID: 30945297
Pomegranate seed oil increased muscle GLUT‑4 expression and modestly lowered fasting glucose in obese T2D patients (mechanistic glycemic benefit).
- Efficacy of Pomegranate Seed Powder on Glucose and Lipid Metabolism in Patients with Type 2 Diabetes: A Prospective Randomized Double-Blind Placebo-Controlled Clinical Trial
PubMed ID: 33302270
8‑week RCT with pomegranate seed powder lowered fasting glucose and HbA1c in T2D patients (improvement in glycemic control over 8 weeks).
- The effect of pomegranate extract on anthropometric indices, serum lipids, glycemic indicators, and blood pressure in patients with nonalcoholic fatty liver disease: A randomized double-blind clinical trial
PubMed ID: 34498307
In NAFLD patients, pomegranate extract significantly lowered total cholesterol, triglycerides and fasting blood sugar and reduced weight/BMI over 12 weeks.
- Pomegranate (Punica granatum L.) peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trial
PubMed ID: 37605174
Pomegranate peel extract for 8 weeks in NAFLD reduced liver stiffness, weight (−5.1 kg) and LDL-C (clinically meaningful metabolic improvements).
- Effectiveness of the pomegranate extract in improving hepatokines and serum biomarkers of non-alcoholic fatty liver disease: A randomized double blind clinical trial
PubMed ID: 36535123
NAFLD trial with improved liver enzymes and antioxidant capacity supports metabolic/liver function.
Blood circulation (10)
- Three-dimensional ultrasound assessment of effects of therapies on carotid atherosclerosis using vessel wall thickness maps
PubMed ID: 34148714
Carotid plaque/thickness mapping found less progression with pomegranate therapy (vascular structural benefit).
- Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease
PubMed ID: 16169367
Reduced stress‑induced ischemia implies improved myocardial perfusion/ischemia burden.
- Effects of pomegranate peel extract and vitamin E on the inflammatory status and endothelial function in hemodialysis patients: a randomized controlled clinical trial
PubMed ID: 32839797
Improved endothelial markers (ICAM/VCAM) in HD patients imply better vascular function.
- Acute and long-term effects of grape and pomegranate juice consumption on vascular reactivity in paediatric metabolic syndrome
PubMed ID: 20170591
Improved flow-mediated dilation (endothelial-dependent function) rapidly and after 1 month in adolescents with metabolic syndrome.
- Does Pomegranate intake attenuate cardiovascular risk factors in hemodialysis patients?
PubMed ID: 24593225
Year-long hemodialysis study reported BP and pulse-pressure reductions, implying improved vascular status in that population.
- Quantification of Local Vessel Wall and Plaque Volume Change for Assessment of Effects of Therapies on Carotid Atherosclerosis Based on 3-D Ultrasound Imaging
PubMed ID: 36566092
Reduced carotid vessel-wall/plaque volume change by sensitive 3-D ultrasound suggests improved vascular health/flow-related measures.
- Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial
PubMed ID: 31646650
PJ in dialysis improved BP and endothelial/oxidative markers—consistent with improved vascular health.
- Effects of pomegranate juice consumption on blood pressure and lipid profile in patients with type 2 diabetes: A single-blind randomized clinical trial
PubMed ID: 30661697
6‑week PJ lowered systolic/diastolic BP in T2D (improved hemodynamics supporting circulation).
- Cardioprotective Effects of Pomegranate (Punica granatum) Juice in Patients with Ischemic Heart Disease
PubMed ID: 28913846
Reduced angina occurrence/duration and troponin during hospitalization suggests improved myocardial perfusion or reduced ischemic burden (short term).
- Effects of Pomegranate Juice on Cardiovascular Risk Factors in Patients with Metabolic Syndrome: a Double-Blinded, Randomized Crossover Controlled Trial
PubMed ID: 28303364
One‑week PJ reduced systolic/diastolic BP in metabolic syndrome (acute circulation benefit).
Immune support (9)
- Effects of pomegranate peel extract and vitamin E on the inflammatory status and endothelial function in hemodialysis patients: a randomized controlled clinical trial
PubMed ID: 32839797
Reduced CRP/IL-6/TNF-α in hemodialysis patients indicates anti-inflammatory effects that can support immune-related inflammation control.
- One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: a randomized placebo-controlled trial
PubMed ID: 22609423
One-year trial in hemodialysis patients showed fewer infection-related hospitalizations and lowered inflammatory/oxidative biomarkers.
- Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: A randomized controlled clinical trial
PubMed ID: 26850805
30‑day RCT reduced hs‑CRP in overweight/obese adults (systemic inflammatory marker relevant to immune activation).
- Effects of Pomegranate Juice on Cardiovascular Risk Factors in Patients with Metabolic Syndrome: a Double-Blinded, Randomized Crossover Controlled Trial
PubMed ID: 28303364
One‑week crossover in metabolic syndrome lowered hs‑CRP (acute anti‑inflammatory signal).
- Pomegranate Juice Increases Sirtuin1 Protein in Peripheral Blood Mononuclear Cell from Patients with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trial
PubMed ID: 29957104
12‑week RCT in T2D showed decreased NF‑κB and increased SIRT1 in PBMCs and lowered endothelial inflammation marker (direct immune/inflammatory pathway modulation).
- The Endotoxemia Marker Lipopolysaccharide-Binding Protein is Reduced in Overweight-Obese Subjects Consuming Pomegranate Extract by Modulating the Gut Microbiota: A Randomized Clinical Trial
PubMed ID: 29665619
High‑dose PE reduced LBP (endotoxemia marker) and shifted gut microbiota toward anti‑inflammatory profile (gut‑immune axis impact).
- Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial
PubMed ID: 31646650
Hemodialysis crossover trial reduced IL‑6 and other inflammatory/oxidative markers during PJ intervention (immune/inflammation benefit in clinical population).
- Adjuvant pomegranate juice intake improves the inflammatory status of hospitalized COVID-19 patients: A randomized and placebo-controlled trial
PubMed ID: 37271189
Hospitalized COVID-19 patients had lower IL-6/CRP and improved oxygen after pomegranate juice, indicating immune/inflammatory modulation.
- Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55-70 Years: A Randomised Controlled Parallel Trial
PubMed ID: 40218993
12-week PE lowered IL-6 in older adults, consistent with anti-inflammatory/immune-modulating effects.
Digestive support (7)
- Effectiveness of the pomegranate extract in improving hepatokines and serum biomarkers of non-alcoholic fatty liver disease: A randomized double blind clinical trial
PubMed ID: 36535123
NAFLD RCT lowered liver enzymes and increased antioxidant capacity—benefit for liver/digestive health.
- A Randomized, Placebo-Controlled Trial Evaluating Multi-Species Synbiotic Supplementation for Bloating, Gas, and Abdominal Discomfort
PubMed ID: 41599868
Large RCT: a synbiotic containing pomegranate extract significantly improved GI QoL, bloating, gas and abdominal discomfort vs placebo.
- Pharmacological Therapy Determines the Gut Microbiota Modulation by a Pomegranate Extract Nutraceutical in Metabolic Syndrome: A Randomized Clinical Trial
PubMed ID: 33458928
Pomegranate extract altered gut microbiota composition (increased beneficial genera in subgroups) and reduced some inflammation/endotoxemia markers.
- The Endotoxemia Marker Lipopolysaccharide-Binding Protein is Reduced in Overweight-Obese Subjects Consuming Pomegranate Extract by Modulating the Gut Microbiota: A Randomized Clinical Trial
PubMed ID: 29665619
High‑dose PE reduced LBP (marker of endotoxemia) and produced beneficial gut‑microbiota shifts—direct gut/digestive effects.
- Pomegranate Juice Supplemented with Inulin Modulates Gut Microbiota and Promotes the Production of Microbiota-Associated Metabolites in Overweight/Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 38887904
PJ+inulin RCT produced significant shifts in gut microbiota and increased SCFAs and pomegranate metabolites, directly indicating digestive/microbiome effects.
- Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients
PubMed ID: 24532260
Pomegranate extract led to measurable urolithin and ellagic-acid metabolites in colon tissue, demonstrating colonic bioavailability relevant to digestive biology.
- Effect of Pomegranate Peel Consumption on Liver Enzymes, Lipid Profile, Liver Steatosis, and Hs-CRP in Patients With Non-alcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
PubMed ID: 39608758
Pomegranate peel improved liver tests and lipids in NAFLD—supports digestive/liver function.
Wellbeing (7)
- Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: A randomized controlled clinical trial
PubMed ID: 26850805
Short‑term metabolic and inflammatory marker improvements in overweight/obese adults may translate to modest general health benefits.
- Influence of a new botanical combination on quality of life in menopausal Spanish women: Results of a randomized, placebo-controlled pilot study
PubMed ID: 34288973
Pilot RCT of a multi-botanical including pomegranate peel improved overall QoL measures versus placebo.
- Pomegranate Juice Increases Sirtuin1 Protein in Peripheral Blood Mononuclear Cell from Patients with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trial
PubMed ID: 29957104
12‑week anti‑inflammatory and endothelial improvements in T2D likely support overall cardiovascular/metabolic well‑being.
- Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial
PubMed ID: 31646650
Multiple biomarker and BP improvements in hemodialysis patients indicate improved clinical status and wellbeing during treatment.
- Effects of pomegranate supplement on menopausal symptoms and quality of life in menopausal women: A double-blind randomized placebo-controlled trial
PubMed ID: 35134697
Pomegranate supplement reduced menopausal symptoms and improved MENQOL scores in a double-blind RCT (direct QoL improvement).
- A proprietary blend of standardized Punica granatum fruit rind and Theobroma cocoa seed extracts mitigates aging males' symptoms: A randomized, double-blind, placebo-controlled study
PubMed ID: 35928723
Pomegranate+cocoa improved testosterone and AMS score (aging‑male symptoms) indicating better overall wellbeing (combo product).
- Polyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial
PubMed ID: 41305622
Polyphenol mixture including pomegranate produced statistically and clinically meaningful improvements in menopausal quality-of-life in some subgroups.
Oral health (8)
- Punica granatum (pomegranate) extract is active against dental plaque
PubMed ID: 17182487
Single 1-minute pomegranate mouthrinse produced ~84% immediate reduction in dental plaque bacteria comparable to chlorhexidine (acute antibacterial effect).
- The antiplaque efficacy of pomegranate mouthrinse
PubMed ID: 21206931
Twice-daily pomegranate mouthrinse reduced plaque accumulation over 4 days and inhibited key periodontal bacteria in vitro (randomized short-term trial).
- Clinical Efficacy of Subgingivally Delivered Punica Granatum Chip and Gel in Management of Chronic Periodontitis Patients
PubMed ID: 34158437
Pomegranate-derived chip placed subgingivally reduced plaque, gingival index and probing pocket depth more than scaling alone in an RCT (strong clinical oral benefit).
- Antibacterial Efficacy of Mouthwash Prepared from Pomegranate, Grape Seed and Guava Extracts against Oral Streptococci: An in Vivo Study
PubMed ID: 29087796
Children rinsing with pomegranate mouthwash twice daily had significantly lower salivary streptococci counts at 48 h and 7 days—direct antimicrobial oral benefit.
- Use of Punica granatum as an antifungal agent against candidosis associated with denture stomatitis
PubMed ID: 12801361
Pomegranate gel applied thrice daily for 15 days cleared or improved denture-related Candida infection in most patients, nearly matching miconazole.
- Pomegranate extract mouth rinsing effects on saliva measures relevant to gingivitis risk
PubMed ID: 19170139
Four‑week pomegranate mouth rinse improved saliva markers associated with lower gingivitis risk.
- Evaluation of the Effects of Punica granatum Flower Tablets on Pain and Healing of Minor Recurrent Aphthous Stomatitis: A Randomized Clinical Trial
PubMed ID: 39016077
Topical pomegranate flower tablets accelerated healing, reduced pain and ulcer size in minor mouth ulcers vs steroid paste (randomized crossover).
- Punica granatum peel extract as adjunct irrigation to nonsurgical treatment of chronic gingivitis
PubMed ID: 33862350
Adjunctive 5% pomegranate peel extract irrigation reduced gingival inflammation versus placebo in chronic gingivitis (RCT evidence).
Skin appearance (7)
- Effects of Pomegranate Extract on IGF-1 Levels and Telomere Length in Older Adults (55-70 Years): Findings from a Randomised Double-Blinded Controlled Trial
PubMed ID: 41010500
Modest IGF-1 increase after 12 weeks of pomegranate extract could signal anabolic/repair processes relevant to youthful physiology; no direct appearance measures.
- A phase II randomized placebo-controlled trial of pomegranate fruit extract in men with localized prostate cancer undergoing active surveillance
PubMed ID: 33095939
Reduction in tissue oxidative DNA damage in prostate tumor tissue indicates antioxidant/anti‑aging potential at a molecular level (limited clinical translation).
- Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial
PubMed ID: 31601842
12‑week RCT in healthy women increased minimal erythema dose (MED) to UVB (objective improvement in skin UV resistance) and altered skin microbiota modestly.
- Comparative effects of a fixed Polypodium leucotomos/Pomegranate combination versus Polypodium leucotomos alone on skin biophysical parameters
PubMed ID: 28456146
Oral Polypodium+pomegranate improved several skin measures (less redness, pigmentation, oiliness) vs Polypodium alone, consistent with skin appearance benefit.
- Phenolic-rich Pomegranate Peel Extract: In Vitro, Cellular, and In Vivo Activities for Skin Hyperpigmentation Treatment
PubMed ID: 32428937
Topical phenolic-rich pomegranate peel formulations improved facial skin lightening and reduced melanogenesis in a split-face trial.
- Effects of oral administration of ellagic acid-rich pomegranate extract on ultraviolet-induced pigmentation in the human skin
PubMed ID: 17190110
Oral ellagic-acid pomegranate extract modestly limited UV-induced skin darkening (preserved luminance) in a randomized trial.
- Fermented pomegranate extracts protect against oxidative stress and aging of skin
PubMed ID: 34416060
Double‑blind trial showed fermented pomegranate improved skin hydration, elasticity, brightness and collagen measures in healthy adults.
Mental clarity (5)
- Beneficial effects of a nano formulation of pomegranate seed oil, GranaGard, on the cognitive function of multiple sclerosis patients
PubMed ID: 34243101
Nano pomegranate seed oil improved verbal memory and overall cognitive z-score in MS patients in a small randomized pilot.
- Maternal pomegranate juice intake and brain structure and function in infants with intrauterine growth restriction: A randomized controlled pilot study
PubMed ID: 31433809
Maternal PJ in pregnancy associated with improved infant white‑matter microstructure and increased functional connectivity on MRI (neurodevelopmental surrogate markers).
- Randomized placebo-controlled study of the memory effects of pomegranate juice in middle-aged and older adults
PubMed ID: 31711104
12‑month RCT preserved visual learning (BVMT‑R) in middle‑aged/older adults vs placebo (cognitive benefit on visual memory).
- A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR
PubMed ID: 33574371
Maternal pomegranate juice in IUGR pregnancies was associated with reduced neonatal brain injury on MRI (neuroprotective signal relevant to brain health).
- The Effects of Pomegranate Seed Oil on Mild Cognitive Impairment
PubMed ID: 38306046
One-year RCT in MCI showed improved global cognition, memory (RAVLT), and processing speed with pomegranate seed oil—direct cognitive benefits.
Weight management (4)
- Effect of synbiotic pomegranate juice on glycemic, sex hormone profile and anthropometric indices in PCOS: A randomized, triple blind, controlled trial
PubMed ID: 30538082
Synbiotic pomegranate juice in PCOS reduced BMI/waist and improved insulin resistance in a randomized 12-week trial—direct support for weight-related metabolic improvement.
- The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat
PubMed ID: 19840063
Xanthigen (fucoxanthin + pomegranate seed oil) randomized trial produced meaningful weight and liver-fat reductions; pomegranate contribution plausible but not isolated.
- Pomegranate (Punica granatum L.) peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trial
PubMed ID: 37605174
Pomegranate peel extract reduced body weight by ~5.1 kg over 8 weeks in NAFLD patients (strong weight-related finding).
- The effect of pomegranate extract on anthropometric indices, serum lipids, glycemic indicators, and blood pressure in patients with nonalcoholic fatty liver disease: A randomized double-blind clinical trial
PubMed ID: 34498307
12-week pomegranate extract in NAFLD lowered weight, BMI and waist circumference along with metabolic improvements.
Mood balance (3)
- Short-term Effect of Fresh Pomegranate Juice on Serum Cortisol and Thyroxine in Patients with type 2 Diabetes
PubMed ID: 31782367
Single‑dose fresh PJ acutely lowered serum cortisol at 1 hour in T2D patients (reduced cortisol may relate to stress/mood regulation, though evidence is acute/single dose).
- Effects of pomegranate supplement on menopausal symptoms and quality of life in menopausal women: A double-blind randomized placebo-controlled trial
PubMed ID: 35134697
Pomegranate supplement reduced menopausal symptoms and improved menopause-specific QoL in RCT (affect and wellbeing improvements).
- The effect of pomegranate supplementation on symptom severity and quality of life in women with premenstrual syndrome: A randomised controlled trial
PubMed ID: 39284531
Pomegranate extract reduced PMS symptoms and improved social quality-of-life—direct mood/affect-related benefits.
Energy & Fatigue (2)
- The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat
PubMed ID: 19840063
Fucoxanthin+PSO product (contains pomegranate seed oil) increased resting energy expenditure in obese women, suggesting an energy/metabolism effect (multicomponent product).
- Combination of Chemically Characterized Pomegranate Extract and Hydrophilic Vitamins against Prolonged Fatigue: A Monocentric, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 37447210
Adults with prolonged fatigue reported significantly less fatigue after 2 months on a pomegranate-extract + B/C vitamin supplement (patient-reported energy).
Joint comfort (2)
- The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis
PubMed ID: 26804926
Knee osteoarthritis RCT showed significant WOMAC symptom improvements and reduced MMP-13, directly supporting joint comfort.
- Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in Rheumatoid Arthritis patients
PubMed ID: 27577177
RA RCT lowered DAS28 and ESR, indicating reduced joint inflammation and symptomatic benefit.
Bone health (1)
- Effects of pomegranate extract in supplementing gonadotropin-releasing hormone therapy on idiopathic central precocious puberty in Chinese girls: a randomized, placebo-controlled, double-blind clinical trial
PubMed ID: 28091641
In girls with central precocious puberty, adding pomegranate extract to GnRH therapy improved bone age/growth velocity and height SDS over 3 months (direct growth/bone development effect as adjunctive therapy).
Similar by evidence
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Products with Pomegranate
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Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.