PQQ
8 benefits mapped to clinical evidence across supplements.
Dose per serving from products
414 products in our catalogue print how much PQQ a serving holds.
Most common: 10 mg to 25 mg, 54% of 414 products.
| Dose per serving | Products |
|---|---|
| 2.5 mg or less | 9 |
| 2.5 mg to 5 mg | 18 |
| 5 mg to 10 mg | 86 |
| 10 mg to 25 mg | 224 |
| 25 mg to 50 mg | 58 |
| over 50 mg | 19 |
Dose per serving from research
6 study groups in 6 studies say how much PQQ participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 10 mg to 25 mg, 100% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 10 mg to 25 mg | 6 |
Benefit Evidence
Research sources
Antioxidant (3)
- Effects of dietary pyrroloquinoline quinone disodium on growth performance, carcass yield and antioxidant status of broiler chicks
PubMed ID: 25229409
Broiler chicks had decreased MDA (lipid peroxidation) when fed PQQ, supporting antioxidant effect in animals.
- Dietary supplementation of pyrroloquinoline quinone disodium protects against oxidative stress and liver damage in laying hens fed an oxidized sunflower oil-added diet
PubMed ID: 26837542
Clear animal evidence: PQQ normalized MDA and restored glutathione in oxidized‑oil challenged hens.
- Effects of dietary pyrroloquinoline quinone disodium on growth, carcass characteristics, redox status, and mitochondria metabolism in broilers
PubMed ID: 25609689
Improved total antioxidant capacity reported in broiler feeding trial, supporting antioxidant action.
Memory (3)
- Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study
PubMed ID: 34415830
Double‑blind RCT in middle‑aged/elderly showed consistent improvements in composite and verbal memory vs placebo.
- The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial
PubMed ID: 38908296
MCI trial (dihydrogen+PQQ) increased BDNF and NAA and improved orientation—biomarkers and cognition consistent with memory benefit (combination product caveat).
- Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions
PubMed ID: 26782228
Improved visuospatial memory in subgroup and attention improvements in elderly, supporting memory support.
Mental clarity (3)
- Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions
PubMed ID: 26782228
Elderly trial improved attention and increased prefrontal blood‑flow, supporting clearer cognition.
- Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study
PubMed ID: 34415830
Randomized human RCT showed broad cognitive improvements and subjective clarity after 12 weeks.
- The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial
PubMed ID: 38908296
Dihydrogen+PQQ trial improved orientation and brain metabolites (BDNF/NAA) supporting clearer cognitive processing (combination product limits attribution).
Cell health (2)
- Effects of dietary pyrroloquinoline quinone disodium on growth performance, carcass yield and antioxidant status of broiler chicks
PubMed ID: 25229409
Animal growth and reduced oxidative stress accompanied by mitochondrial‑relevant enzyme improvements, supporting mitochondrial support.
- Effects of dietary pyrroloquinoline quinone disodium on growth, carcass characteristics, redox status, and mitochondria metabolism in broilers
PubMed ID: 25609689
Broiler studies reported increased citrate synthase and mitochondrial enzyme activity, supporting direct mitochondrial effects in animals.
Focus & concentration (2)
- Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study
PubMed ID: 34415830
Broad cognitive domain improvements included reaction time and attention-related metrics consistent with better focus.
- Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions
PubMed ID: 26782228
Elderly RCT improved selective attention (Stroop) and increased prefrontal hemodynamics—strong support for focus enhancement.
Healthy aging (2)
- The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial
PubMed ID: 38908296
Biomarker (NAA) and BDNF increases in MCI group suggest neuroprotective/aging‑relevant effects (combination product caveat).
- Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study
PubMed ID: 34415830
Cognitive preservation in middle‑aged/elderly participants supports healthy brain aging.
Energy & Fatigue (1)
- Effects of dietary pyrroloquinoline quinone disodium on growth, carcass characteristics, redox status, and mitochondria metabolism in broilers
PubMed ID: 25609689
Broiler trial reported increased citrate synthase activity and antioxidant capacity—markers of enhanced cellular/mitochondrial function.
Nerve health (1)
- The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial
PubMed ID: 38908296
Increases in NAA (neuronal integrity marker) and BDNF in MCI trial support neuronal/nerve health (combination product limits attribution).
Forms of PQQ
The form a label may print instead of PQQ. Each is a different substance with its own identifier, and none of them has research of its own — the studies are the ones on this page.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with PQQ
Search all560 products whose verified label declares PQQ — not every bottle that mentions it in a title.