Ginseng
18 benefits mapped to clinical evidence across supplements.
Dose per serving from products
906 products in our catalogue print how much Ginseng a serving holds.
Most common: 50 mg to 100 mg, 24% of 906 products.
| Dose per serving | Products |
|---|---|
| 2.5 mg or less | 23 |
| 2.5 mg to 5 mg | 50 |
| 5 mg to 10 mg | 18 |
| 10 mg to 25 mg | 167 |
| 25 mg to 50 mg | 210 |
| 50 mg to 100 mg | 216 |
| 100 mg to 250 mg | 112 |
| 250 mg to 500 mg | 47 |
| 500 mg to 1 g | 36 |
| over 1 g | 27 |
Dose per serving from research
77 study groups in 44 studies say how much Ginseng participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 g to 5 g, 38% of 77 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mg or less | 4 |
| 100 mg to 250 mg | 10 |
| 250 mg to 500 mg | 12 |
| 500 mg to 1 g | 10 |
| 1 g to 2.5 g | 10 |
| 2.5 g to 5 g | 29 |
| over 5 g | 2 |
Benefit Evidence
Inflammation/symptoms recovery
Blood loss −3.4pp
Function/quality-of-life recovery
Immune boost: IgA, T-cells
+35% NK/Phagocytosis
Inflammation down, immunity up
Fatigue ↓, cognition ↑
Exercise capacity ↑, fatigue ↓
Biomarkers improved, fatigue ↓
Cognition/memory +2 points
Fatigue/oxidative stress less
Respiratory/cardiac events down
Digestive recovery +flatus
Less symptoms, gas
Bowel motility +1 day
Inflammation/symptoms recovery
Blood loss −3.4pp
Function/quality-of-life recovery
Immune boost: IgA, T-cells
+35% NK/Phagocytosis
Inflammation down, immunity up
Fatigue ↓, cognition ↑
Exercise capacity ↑, fatigue ↓
Biomarkers improved, fatigue ↓
Cognition/memory +2 points
Fatigue/oxidative stress less
Respiratory/cardiac events down
Research sources
Illness recovery (44)
- Effect of two administration routes of Shenmai Injection () on pulmonary gas exchange function after tourniquet-induced ischemia-reperfusion
PubMed ID: 27299461
IV Shenmai protected lungs and lowered inflammatory markers after ischemia‑reperfusion—supportive of organ recovery mitigation.
- The effects of the herbal medicine Daikenchuto (TJ-100) after esophageal cancer resection, open-label, randomized controlled trial
PubMed ID: 29892933
TJ‑100 (contains ginseng) significantly reduced postoperative weight loss and tended to lessen inflammation after esophagectomy—strong recovery signal (multi‑herb).
- Effect of herbal medicine daikenchuto on oral and enteral caloric intake after liver transplantation: A multicenter, randomized controlled trial
PubMed ID: 29747091
Daikenchuto accelerated postoperative oral intake and improved portal flow after liver transplant—benefit for postoperative recovery (contains ginseng).
- The utility of traditional Chinese medicine (Shenmai) in the cardiac rehabilitation after coronary artery bypass grafting: A single-center randomized clinical trial
PubMed ID: 31779994
Shenmai added to cardiac rehab increased early discharge 6MWD—improves early functional recovery (multi‑ingredient product).
- Effects of Daikenchuto on postoperative gastrointestinal motility in colorectal carcinoma patients with abdominal pain and distension: a prospective, randomized trial
PubMed ID: 32588153
Perioperative Daikenchuto reduced postoperative bowel symptoms (supports post‑surgical recovery of bowel function).
- Korean red ginseng for cancer-related fatigue in colorectal cancer patients with chemotherapy: A randomised phase III trial
PubMed ID: 32172198
KRG reduced chemotherapy‑related fatigue and improved QoL domains—facilitates recovery/functional status during treatment.
- Prophylactic efficacy of ninjin'yoeito for oxaliplatin-induced cumulative peripheral neuropathy in patients with colorectal cancer receiving postoperative adjuvant chemotherapy: a randomized, open-label, phase 2 trial (HOPE-2)
PubMed ID: 32232692
Ninjin'yoeito (contains ginseng) markedly reduced oxaliplatin cumulative neuropathy and preserved chemo dosing (helps recovery/continuation of therapy).
- Efficacy of the Panax Notoginseng Ejiao Suppository in the Treatment of Patients with Ulcerative Proctitis and Its Effect on Inflammatory Response and Immune Function
PubMed ID: 36188425
Panax notoginseng–Ejiao suppository lowered inflammation and reduced recurrence in ulcerative proctitis (improves symptom recovery and relapse prevention).
- Protective effects of Panax ginseng against doxorubicin-induced cardiac toxicity in patients with non-metastatic breast cancer: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 35975564
Adjunctive Panax ginseng reduced anthracycline cardiotoxicity and preserved LVEF during chemo (supports recovery and organ protection during therapy).
- Efficacy and Safety of Panax notoginseng Saponins in the Treatment of Adults With Ischemic Stroke in China: A Randomized Clinical Trial
PubMed ID: 37338907
Large double‑blind RCT: Panax notoginseng saponins increased proportion functionally independent after ischemic stroke (strong recovery/outcome benefit).
- Effects of Panax Ginseng on Health-Related Quality of Life in Patients with Non-Metastatic Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Ginseng for HRQOL in Breast Cancer
PubMed ID: 37218691
Panax ginseng prevented declines in physical well‑being during chemotherapy, indicating support for recovery/function in treatment period.
- Ginseng Berry Concentrate Alleviates Fatigue in Humans: A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial
PubMed ID: 41022533
Antifatigue effects and lower lactic acid suggest support for recovery from exertional or chronic fatigue states.
- Evaluation of TU-100 (Daikenchuto), a Traditional Japanese Kampo Medicine, as an Adjunct to Enhanced Recovery After Surgery, for Acceleration of Gastrointestinal Recovery After Bowel Resection: Results of a Proof-of-Concept, Phase 2, Randomized, Double-Blinded, Placebo-Controlled Trial
PubMed ID: 41114550
TU-100 (contains ginseng) shortened hospital stay and modestly accelerated GI recovery after bowel resection (large trial; primary endpoint not met).
- Safety and efficacy of Ninjin'yoeito along with iron supplementation therapy for preoperative anemia, fatigue, and anxiety in patients with gynecological disease: an open-label, single-center, randomized phase-II trial
PubMed ID: 35701778
Ninjin'yoeito plus iron improved preoperative anemia correction and reduced fatigue/anxiety—supports perioperative recovery and readiness.
- A new way: alleviating postembolization syndrome following transcatheter arterial chemoembolization
PubMed ID: 19216654
Ginsenosides + dexamethasone reduced post‑embolization symptoms and improved liver enzymes after TACE — supports symptomatic recovery.
- [Effect of rhubarb as the main composition of sequential treatment in patients with acute paraquat poisoning: a prospective clinical research]
PubMed ID: 25891453
Sequential Western+TCM regimen including ginseng hastened toxin elimination and shortened hospital stay in paraquat poisoning (multi‑herbal protocol) — recovery benefit though attribution to ginseng is weak.
- Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial
PubMed ID: 28753932
Red ginseng improved HRQL and reduced genotoxicity in chemo patients during recovery from chemotherapy‑related damage.
- Improvement of hematoma absorption and neurological function in patients with acute intracerebral hemorrhage treated with Xueshuantong
PubMed ID: 23062408
Xueshuantong (Panax notoginseng components) accelerated hematoma absorption and improved neurologic scores after ICH — clear recovery‑related benefit.
- [Effect of cellular immune supportive treatment on immunity of esophageal carcinoma patients after modern two-field lymph node dissection]
PubMed ID: 17626759
Perioperative Shenqi injection (contains ginseng) improved early postoperative cellular immunity markers, supportive of surgical recovery.
- [Effects of Hengyan medicinal recipe on the regulation of immunity in patients with severe sepsis: a prospective clinical trial]
PubMed ID: 21315002
Severe sepsis patients given multi‑herb including red ginseng showed lower IL‑6/TNF and higher CD4+ counts at day 7—supports acute recovery of immune function.
- Effects of Astragalus membranaceus and Panax notoginseng Saponins Extract on the Pharmacokinetics of Whey Protein Absorption, Intestinal Permeability, and Muscle Function: A Pilot Study
PubMed ID: 41683325
Panax+Astragalus saponin extract increased BCAA absorption, modestly increased muscle mass and grip strength over 4 weeks—supports nutritional recovery and muscle rebuilding.
- The beneficial effects of Kampo medicine Dai-ken-chu-to after hepatic resection: a prospective randomized control study
PubMed ID: 23435143
Dai‑kenchu‑to shortened time to gastrointestinal recovery (flatus/bowel movements) after liver surgery—clinical recovery metric (multi‑ingredient product).
- [The effect of salvia miltiorrhiza and shengmai on inflammatory mediator and renal function of post-operative patients with obstructive jaundice]
PubMed ID: 12528557
Shengmai‑containing therapy lowered inflammatory mediators and improved renal markers after surgery (supports recovery; multi‑herb).
- [Effect of combined therapy of shenmai and compound danshen injection on myocardial reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction]
PubMed ID: 15250199
Shenmai + danshen reduced inflammatory markers and improved early cardiac function after AMI (supports peri‑procedural recovery).
- [Protective effects of ginsenoside on myocardiac ischemic and reperfusion injuries]
PubMed ID: 7842343
Ginsenosides used during cardioplegia improved postoperative cardiac function/ultrastructure (supports recovery).
- [Effects of Shenmai injection on immune function in stomach cancer patients after chemotherapy]
PubMed ID: 8580688
Shenmai injection (contains ginseng) aided immune recovery after chemotherapy in stomach cancer patients.
- [Study on effect of shenmai injection in protecting myocardium against ischemia-reperfusion injury in thrombolytic therapy with urokinase for acute myocardial infarction patients evaluated by 99mTc-MIBI myocardial imaging]
PubMed ID: 12577392
Adjunctive Shengmai therapy after thrombolysis reduced ischemic area and improved EF — supports myocardial recovery (multi‑herb intervention).
- Ginseng improves pulmonary functions and exercise capacity in patients with COPD
PubMed ID: 12814035
Improved pulmonary function and exercise capacity in COPD implies enhanced recovery/functional status over 3 months.
- [Effect of shenmai injection on diaphragmatic fatigue in children with respiratory failure]
PubMed ID: 12585186
Rapid clinical improvement and diaphragmatic fatigue resolution in pediatric respiratory failure with Shengmai injection — strong recovery signal in acute care context.
- [Clinical observation on effect of xuesaitong injection as auxiliary treatment of severe craniocerebral injury]
PubMed ID: 15074087
Panax notoginseng injection added to usual care improved intracranial pressure, GCS and 3‑month outcomes after severe head injury—direct recovery benefits.
- [Clinical observation on shenmai injection in preventing and treating adverse reaction of chemotherapy on advanced non-small cell lung cancer]
PubMed ID: 16841676
Shenmai improved QoL, maintained weight and reduced chemo adverse reactions in lung cancer patients—supports recovery/tolerance of therapy.
- [Effects of shenmai injection on the clinical efficacy of noninvasive ventilation in patients with severe respiratory failure caused by chronic obstructive pulmonary disease]
PubMed ID: 16983914
Shenmai shortened ventilation and hospital stay and improved gas exchange in severe COPD—clinical recovery endpoints improved.
- [Effect of Shenfu injection in postoperative recovery after abdominal surgery]
PubMed ID: 17455472
Faster return of flatus and improved oxidative/immune markers indicate enhanced postoperative recovery with Shenfu (multi‑component).
- [Effect of Panax notoginseng saponins on serum neuronal specific enolase and rehabilitation in patients with cerebral hemorrhage]
PubMed ID: 17343007
Panax notoginseng saponins lowered NSE and improved NIHSS/Barthel Index after cerebral hemorrhage, indicating neurologic recovery benefit.
- Effect of Shengmai Injection on cardiac function and inflammatory reaction in patients with acute coronary syndrome
PubMed ID: 18679601
Shengmai improved cardiac function and lowered inflammation in ACS patients, supporting recovery/functional improvement.
- [Effect of yiqi wenyang huoxue recipe on bone marrow stem cells' mobilization and its influence on heart function in patients with myocardial infarction]
PubMed ID: 19317161
Multi‑herb treatment including ginseng improved infarct size and LVEF after MI and mobilized progenitor cells—strong recovery signal (multi‑component).
- Effects of combined Chinese drugs and chemotherapy in treating advanced non-small cell lung cancer
PubMed ID: 20082245
Chinese drug package (includes ginseng) added to chemo increased tumor response and median survival, supporting oncologic recovery/benefit (multi‑component).
- [Efficacy of Shenyi Capsule combined with gemcitabine plus cisplatin in treatment of advanced esophageal cancer: a randomized controlled trial]
PubMed ID: 19912736
Shenyi capsule plus chemotherapy lowered VEGF, reduced chemo side effects and increased 1‑year survival—supports treatment recovery/reduction in toxicity.
- Radix/rhizoma notoginseng extract (sanchitongtshu) for ischemic stroke: a randomized controlled study
PubMed ID: 21094030
Panax notoginseng extract added to low‑dose aspirin improved neurological deficit scores and activities of daily living after ischemic stroke (RCT, combination therapy).
- The effects of the Kampo medicine (Japanese herbal medicine) "Daikenchuto" on the surgical inflammatory response following laparoscopic colorectal resection
PubMed ID: 22202972
Daikenchuto reduced postoperative inflammation and accelerated bowel recovery after laparoscopic colorectal surgery (multi‑herb product including ginseng).
- Daikenchuto stimulates colonic motility after laparoscopic-assisted colectomy
PubMed ID: 24895799
Daikenchuto (contains ginseng) shortened time to first flatus/bowel movement after colectomy, suggesting faster GI recovery (multi‑herb).
- [Effects of acupuncture and "Tongxinluo" capsule on plasma lysophosphatidic acid level in patients with acute cerebral infarction]
PubMed ID: 25632575
Acute stroke patients improved more when treated with regimens including Panax notoginseng saponins—supports enhanced recovery in multimodal therapy.
- Ginsenoside Rd Is Efficacious Against Acute Ischemic Stroke by Suppressing Microglial Proteasome-Mediated Inflammation
PubMed ID: 26081140
Pooled trials: ginsenoside Rd improved disability and neurologic outcomes after acute ischemic stroke—strong recovery support.
- Adjuvant effects of fermented red ginseng extract on advanced non-small cell lung cancer patients treated with chemotherapy
PubMed ID: 26142337
Fermented red ginseng improved fatigue and reduced chemo toxicities—adjunctive recovery support during chemotherapy.
Blood circulation (41)
- Xinyue Capsule in patients with stable coronary artery disease after percutaneous coronary intervention: a multicenter, randomized, placebo-controlled trial
PubMed ID: 32446979
Large multicenter RCT: Panax quinquefolius saponins (Xinyue) reduced major cardiac events after PCI (strong cardiovascular/circulatory benefit).
- [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]
PubMed ID: 15143716
Panax notoginseng saponins (PNS) reduced platelet activation/aggregation and altered vasoactive markers vs aspirin in hyperviscosity patients — direct circulation support evidence.
- Improvement of hematoma absorption and neurological function in patients with acute intracerebral hemorrhage treated with Xueshuantong
PubMed ID: 23062408
Xueshuantong (contains Panax notoginseng) accelerated hematoma absorption and reduced inflammatory markers after intracerebral hemorrhage — supports vascular/haemostatic effects.
- Combination of Panax notoginseng saponins and aspirin potentiates platelet inhibition with alleviated gastric injury via modulating arachidonic acid metabolism
PubMed ID: 33370633
PNS added to aspirin increased platelet inhibition and reduced TXB2/COX‑1 oxylipids while improving gastric symptoms — clinically relevant circulatory modulation.
- [Effects of Astragalus and saponins of Panax notoginseng on MMP-9 in patients with type 2 diabetic macroangiopathy]
PubMed ID: 15706857
Panax notoginseng saponins in diabetic macroangiopathy reduced MMP‑9 (vascular remodeling marker) and improved lipid profile—direct vascular benefit.
- Effects of huoxin formula on the arterial functions of patients with coronary heart disease
PubMed ID: 31199705
Huoxin multi‑herb adjunct including Panax notoginseng improved IMT progression, decreased CAVI/ABI and lowered inflammatory mediators in CHD patients (clinical arterial function improvements).
- Effect of American ginseng (Panax quinquefolius L.) on arterial stiffness in subjects with type-2 diabetes and concomitant hypertension
PubMed ID: 23973636
12‑week RCT: 3 g/day American ginseng in people with T2D and hypertension reduced radial augmentation index (−5.3%) and systolic BP (−11.7%) vs placebo—strong clinical vascular effects.
- [Clinical study on effect of Shenmai Injection in treating congestive heart failure]
PubMed ID: 14666758
Shenmai injection (contains ginseng) improved hemodynamics and heart function in CHF patients (human clinical hemodynamic data).
- [Effect of combined therapy of shenmai and compound danshen injection on myocardial reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction]
PubMed ID: 15250199
Shenmai plus danshen improved early LV function (Tei index) and reduced oxidative/inflammatory markers after AMI.
- The efficacy of Chinese herbal medicines on acute coronary syndrome with renal insufficiency after percutaneous coronary intervention
PubMed ID: 31689480
Adjunct Chinese herbal regimen including American ginseng extract reduced cardiac events after PCI—clinical cardiovascular outcome signal (multi‑herb).
- Antiedema effects of Siberian ginseng in humans and its molecular mechanism of lymphatic vascular function in vitro
PubMed ID: 27333960
Siberian ginseng acutely reduced lower‑limb edema via lymphatic endothelial activation (direct circulation/lymphatic effect).
- Vascular effects of combined enriched Korean Red ginseng (Panax Ginseng) and American ginseng (Panax Quinquefolius) administration in individuals with hypertension and type 2 diabetes: A randomized controlled trial
PubMed ID: 32147072
Enriched Korean Red + American ginseng produced a small but significant reduction in central systolic blood pressure in hypertensive/diabetic patients.
- [Clinical and experimental study of shenshao tongguan pian in treating angina pectoris of coronary heart disease]
PubMed ID: 2268917
Large RCT of a TCM containing ginseng reported marked improvements in angina symptoms and ECG (strong clinical circulation signal, multi‑ingredient product).
- [Protective effects of ginsenoside on myocardiac ischemic and reperfusion injuries]
PubMed ID: 7842343
Adding ginsenosides during cardioplegia associated with better postoperative cardiac function and myocardial ultrastructure.
- [Clinical study on xinkening in treating asymptomatic myocardial ischemia in coronary heart disease]
PubMed ID: 7950196
Small trial of a ginseng‑containing treatment reduced ECG markers and total time of asymptomatic myocardial ischemia.
- [Effects of red ginseng on the congestive heart failure and its mechanism]
PubMed ID: 7549378
Red ginseng improved hemodynamic and biochemical markers in severe heart failure (small RCT).
- [Comparative study on effect of Panax notoginseng and ticlid in treating early diabetic nephropathy]
PubMed ID: 11475719
Panax notoginseng altered thromboxane/PGF1α and reduced urinary albumin in diabetic kidney disease — favorable vascular/thrombotic effects.
- [Effect of Panax notoginseng saponins combined isovolumic haemodilution on the retinal microcirculation of patients with retinal vein occlusion]
PubMed ID: 12206008
Panax notoginseng plus haemodilution improved retinal circulation time and lesion recovery in retinal vein occlusion — microcirculatory benefit.
- [Study on effect of shenmai injection in protecting myocardium against ischemia-reperfusion injury in thrombolytic therapy with urokinase for acute myocardial infarction patients evaluated by 99mTc-MIBI myocardial imaging]
PubMed ID: 12577392
Shengmai (multi‑herb) adjunct to thrombolysis reduced ischemic myocardial area and increased EF — improved cardiac perfusion/function reported.
- [Effect of shengmai injection on hemodynamics in patients with dilated cardiomyopathy]
PubMed ID: 12584790
Shengmai injection added to care in DCM improved EF and stroke volume and lowered vascular resistance — positive hemodynamic effects (multi‑herb context).
- [Influence of large amount of shengmai injection on blood coagulation in patients with chronic heart failure]
PubMed ID: 12764910
Shengmai injection (contains ginseng) plus usual care reduced P‑selectin, vWF and D‑dimer in chronic heart failure—markers relevant to coagulation/vascular function.
- [Effect of Shenfu injection in postoperative recovery after abdominal surgery]
PubMed ID: 17455472
Shenfu injection lowered whole blood viscosity and related hemorheology measures postoperatively (multi‑component product).
- Effect of Shengmai Injection on cardiac function and inflammatory reaction in patients with acute coronary syndrome
PubMed ID: 18679601
Shengmai injection increased EF/CO/stroke volume and lowered hs‑CRP in acute coronary syndrome patients (multi‑herb adjunctive therapy).
- Effect of Shengmai injection on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus
PubMed ID: 19082800
Shengmai injection produced large improvements in NO/ET‑1/AngII and EF in CHD with diabetes (randomized, multi‑herb product).
- [Effect of yiqi wenyang huoxue recipe on bone marrow stem cells' mobilization and its influence on heart function in patients with myocardial infarction]
PubMed ID: 19317161
Multi‑herb formula (includes ginseng) increased peripheral CD34+ cells and improved LVEF and infarct size after MI.
- Supplementation of cheonggukjang and red ginseng cheonggukjang can improve plasma lipid profile and fasting blood glucose concentration in subjects with impaired fasting glucose
PubMed ID: 21128827
Red ginseng–enriched product lowered total and LDL cholesterol, supporting vascular/circulatory risk factor improvement.
- Red ginseng extract improves coronary flow reserve and increases absolute numbers of various circulating angiogenic cells in patients with first ST-segment elevation acute myocardial infarction
PubMed ID: 20641058
Randomized post‑MI trial showing increased coronary flow reserve and early mobilization of angiogenic cells with red ginseng—robust cardiovascular biologic effects.
- Study on improving blood flow with Korean red ginseng substances using digital infrared thermal imaging and Doppler sonography: randomized, double blind, placebo-controlled clinical trial with parallel design
PubMed ID: 23596810
Thermal imaging study showed improved peripheral thermal distribution (proxy for circulation) though Doppler unchanged.
- Efficacy and safety of Korean red ginseng for cold hypersensitivity in the hands and feet: a randomized, double-blind, placebo-controlled trial
PubMed ID: 25284751
8‑week RCT objectively increased hand/foot skin temperatures and improved rewarming and symptoms in cold hypersensitivity (vascular effect).
- Combination of autologous transplantation of G-CSF-mobilized peripheral blood mononuclear cells and Panax notoginseng saponins in the treatment of unreconstructable critical limb ischemia
PubMed ID: 24632316
Adding Panax notoginseng saponins to cell therapy significantly improved ABI, TcPO2 and walking distance in critical limb ischemia—strong vascular/flow signal.
- Clinical study of Butylphthalide combined with Xue Shuan Tong on serum inflammatory factors and prognosis effect of patients with cerebral infarction
PubMed ID: 26525022
Xue Shuan Tong reduced carotid intima‑media thickness and inflammatory markers—vascular structural improvements reported.
- Ginsenoside Rd Is Efficacious Against Acute Ischemic Stroke by Suppressing Microglial Proteasome-Mediated Inflammation
PubMed ID: 26081140
Pooled trials of ginsenoside Rd improved neurologic outcomes after ischemic stroke—supports cerebrovascular therapeutic effect.
- A randomized, double-blind, multicenter, placebo-controlled clinical study on the efficacy and safety of Shenmai injection in patients with chronic heart failure
PubMed ID: 27045864
Shenmai injection improved functional class and 6MWD in chronic heart failure patients—supportive of circulatory/functional benefit (short term).
- Blood pressure-lowering effect of Korean red ginseng associated with decreased circulating Lp-PLA2 activity and lysophosphatidylcholines and increased dihydrobiopterin level in prehypertensive subjects
PubMed ID: 26843120
Korean red ginseng lowered systolic and diastolic BP and favorably changed vascular/inflammatory metabolites in prehypertensive adults—robust BP/circulation evidence.
- [Effect of Shenmai Injection on Vascular Endothelial Dependence Diastolic Function in Coronary Heart Disease Patients]
PubMed ID: 30650479
Shenmai (contains ginseng) improved endothelial‑dependent vasodilation, increased NO, and lowered vasoconstrictor markers—strong circulation signal (multi‑component).
- Effects of Shenmai injection on the values of CO, SV, and EF in patients undergoing off-pump coronary artery bypass graft: A randomized, clinical trial
PubMed ID: 29517675
Shenmai infusion produced intraoperative increases in cardiac output, stroke volume and EF in CABG patients—hemodynamic/circulatory improvement.
- Effect of Korean Red Ginseng on Cholesterol Metabolites in Postmenopausal Women with Hypercholesterolemia: A Pilot Randomized Controlled Trial
PubMed ID: 33171597
KRG modestly lowered cholesterol metabolites and produced a small DBP decrease in postmenopausal women (favorable vascular risk marker changes).
- Protective effects of Panax ginseng against doxorubicin-induced cardiac toxicity in patients with non-metastatic breast cancer: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 35975564
Small RCT: Panax ginseng adjunct during anthracycline chemo preserved LVEF and reduced cardiotoxicity incidence (direct cardioprotective/circulatory support).
- The effect of Tianjiang Xueshuantong Wan pills on ischemia-reperfusion injury after thrombolysis in acute cerebral infarction
PubMed ID: 35246395
After thrombolysis, Panax‑containing therapy reduced reperfusion‑inflammation markers and improved neurologic deficits (supports vascular/reperfusion protection).
- Efficacy and Safety of Panax notoginseng Saponins in the Treatment of Adults With Ischemic Stroke in China: A Randomized Clinical Trial
PubMed ID: 37338907
Large trial: Panax notoginseng saponins increased functional independence after ischemic stroke—benefit in cerebrovascular recovery/circulation.
- Efficacy of Xueshuantong Injection in Reducing Residual Inflammatory Risk in Unstable Angina Patients: A Randomized Double-Blind Controlled Trial
PubMed ID: 41111082
Xueshuantong reduced CRP/IL-6 and other markers in unstable angina, suggesting cardiovascular/circulatory benefit.
Immune support (27)
- [Effect of cellular immune supportive treatment on immunity of esophageal carcinoma patients after modern two-field lymph node dissection]
PubMed ID: 17626759
Perioperative Shenqi injection (contains ginseng) improved early postoperative T‑cell subsets (CD3+CD4+, CD4+/CD8+).
- [Effects of Hengyan medicinal recipe on the regulation of immunity in patients with severe sepsis: a prospective clinical trial]
PubMed ID: 21315002
Multi‑herb recipe including red ginseng reduced IL‑6 and TNF‑α and increased CD4+ T cells in severe sepsis patients (clinical immune marker improvements).
- Effects of a new nutraceutical ingredient on allergen-induced sulphidoleukotrienes production and CD63 expression in allergic subjects
PubMed ID: 18817894
Mixed‑plant nutraceutical containing Panax reduced leukotriene production (−43%) and basophil activation (CD63 −64.8%) in allergic subjects (large biomarker changes).
- [Effect of Tangyikang in improving the function of pancreatic islet beta cells in patients with latent autoimmune diabetes mellitus in adults]
PubMed ID: 19123322
Herbal decoction including red ginseng altered cytokines (↑IL‑4, ↓IFN‑γ) and improved beta‑cell autoimmunity markers in LADA patients.
- Treatment of 37 patients with refractory idiopathic thrombocytopenic purpura by shengxueling
PubMed ID: 17578315
Ginseng‑saponin preparation increased clinical response in refractory ITP (immune/hematologic effect).
- Immunomodulatory effects of two extracts of Panax ginseng C.A. Meyer
PubMed ID: 2100737
8‑week RCT showing increases in PMN chemotaxis, phagocytosis and intracellular killing with ginseng extract.
- [Effects of Shenmai injection on immune function in stomach cancer patients after chemotherapy]
PubMed ID: 8580688
Shenmai (contains ginseng) improved T cell counts and NK/LAK activity after chemotherapy.
- Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold [corrected]
PubMed ID: 8879982
Large RCT: G115 increased vaccine antibody titres, NK activity and markedly reduced respiratory infections — strong immune support.
- [Clinical observation on nasopharyngeal carcinoma treated with combined therapy of radiotherapy and ginseng polysaccharide injection]
PubMed ID: 12577414
Ginseng polysaccharide injection raised NK/LAK activity and modestly improved remission in NPC — supports immune stimulation (in combined therapy setting).
- A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults
PubMed ID: 14687309
CVT-E002 (North American ginseng extract) substantially reduced laboratory‑confirmed influenza/RSV and symptom burden in institutionalized elderly.
- Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial
PubMed ID: 16247099
North American ginseng extract reduced number, severity and duration of common colds in adults over a 4‑month season.
- [Influence of Shenmai injection on blood serum tumor necrosis factor and bone marrow CD34+ cell's apoptosis of chronic aplastic anemia patient]
PubMed ID: 16245914
Shenmai (ginseng-containing) plus standard therapy lowered TNF‑α and improved clinical response in aplastic anemia—immunomodulatory marker changes.
- Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial
PubMed ID: 16566675
COLD-fX (North American ginseng extract) reduced incidence and duration of acute respiratory illnesses in seniors—clinical immune benefit.
- [Effect of Shenfu injection in postoperative recovery after abdominal surgery]
PubMed ID: 17455472
Shenfu increased IgG/IgA postoperatively, suggesting some immune modulation (multi-component).
- [Clinical study on effect of total panax notoginseng saponins on immune related inner environment imbalance in rheumatoid arthritis patients]
PubMed ID: 17717913
Panax notoginseng saponins reduced CRP and other inflammatory indices in RA, indicating anti‑inflammatory/immune effects.
- [Impact of shengmal injection on changes of immunological function in patients after cardiopulmonary bypass]
PubMed ID: 19526756
Shengmai altered perioperative WBC, neutrophils and cytokines consistent with immune modulation (multi‑component product).
- Preventive effect of Korean red ginseng for acute respiratory illness: a randomized and double-blind clinical trial
PubMed ID: 23255845
Large RCT showed a significant reduction in acute respiratory illness incidence with KRG.
- A randomized, controlled trial of Panax quinquefolius extract (CVT-E002) to reduce respiratory infection in patients with chronic lymphocytic leukemia
PubMed ID: 22266154
In CLL patients, American ginseng increased antibody seroconversion to respiratory viruses despite no clinical ARI reduction.
- A 14-week randomized, placebo-controlled, double-blind clinical trial to evaluate the efficacy and safety of ginseng polysaccharide (Y-75)
PubMed ID: 25297058
14‑week RCT in older adults showed large increases in NK activity, phagocytosis and TNF‑α with a ginseng polysaccharide.
- Effect of ginseng polysaccharides and dendritic cells on the balance of Th1/Th2 T helper cells in patients with non-small cell lung cancer
PubMed ID: 25618966
Adding ginseng polysaccharides to dendritic‑cell therapy shifted cytokines toward Th1 (immune biomarker effects; combined therapy).
- Impact of extended ginsenoside Rb1 on early chronic kidney disease: a randomized, placebo-controlled study
PubMed ID: 27853891
Ginsenoside Rb1 reduced inflammation and oxidative stress in early CKD patients—clinically relevant immune/inflammatory benefit.
- The Effect of Korean Red Ginseng on Symptoms and Inflammation in Patients With Allergic Rhinitis
PubMed ID: 32070136
KRG lowered Th2 biomarkers (IL‑4, nasal eosinophils, IgE) and improved allergic symptoms—direct immunomodulatory effects in allergy.
- Efficacy of the Panax Notoginseng Ejiao Suppository in the Treatment of Patients with Ulcerative Proctitis and Its Effect on Inflammatory Response and Immune Function
PubMed ID: 36188425
Ulcerative proctitis trial showed improved Th17/Treg balance and reduced inflammatory cytokines with Panax notoginseng formulation (immune modulation).
- The effect of Tianjiang Xueshuantong Wan pills on ischemia-reperfusion injury after thrombolysis in acute cerebral infarction
PubMed ID: 35246395
Post‑thrombolysis formula reduced IL‑6 and TNF and other reperfusion/inflammatory markers (immuno‑inflammatory benefit with Panax-containing product).
- Effect of Baihe Gujin decoction combined with Shengmai powder on the expression of IL-1β and IL-1Ra in peripheral blood CD14+ monocytes from patients with pulmonary tuberculosis
PubMed ID: 35869725
Herbal adjunct lowered IL‑1β/IL‑1Ra gene expression in monocytes in TB patients (reduced proinflammatory gene expression; contains Shengmai/Shengmai-related herbs including Panax).
- Korean Red Ginseng Potentially Improves Maintaining Antibodies after COVID-19 Vaccination: A 24-Week Longitudinal Study
PubMed ID: 37049424
Korean red ginseng users had a sustained vaccine antibody response over 24 weeks (large cohort; nonrandomized).
- Efficacy of Xueshuantong Injection in Reducing Residual Inflammatory Risk in Unstable Angina Patients: A Randomized Double-Blind Controlled Trial
PubMed ID: 41111082
Xueshuantong injection reduced inflammatory markers (CRP, IL‑6) in unstable angina, consistent with immune/inflammatory modulation.
Energy & Fatigue (17)
- Ginseng Berry Concentrate Alleviates Fatigue in Humans: A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial
PubMed ID: 41022533
Ginseng berry concentrate reduced subjective fatigue scores and resting lactic acid versus placebo in fatigued adults.
- Safety and efficacy of Ninjin'yoeito along with iron supplementation therapy for preoperative anemia, fatigue, and anxiety in patients with gynecological disease: an open-label, single-center, randomized phase-II trial
PubMed ID: 35701778
Ninjin'yoeito (contains ginseng) plus iron produced greater fatigue reductions than iron alone in preoperative anemia patients (direct clinical fatigue improvement).
- The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study
PubMed ID: 34578969
8‑week RCT in postmenopausal women: KRG reduced fatigue severity (FSS) and increased mitochondrial DNA (plausible mechanism), direct evidence of fatigue reduction.
- Korean red ginseng for cancer-related fatigue in colorectal cancer patients with chemotherapy: A randomised phase III trial
PubMed ID: 32172198
Large phase III RCT: KRG taken during chemotherapy reduced cancer‑related fatigue and improved fatigue-related QoL measures (direct clinical fatigue benefit).
- Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA
PubMed ID: 19415341
Large randomized dose‑finding trial showed dose‑dependent trends (especially high doses) toward reduced cancer‑related fatigue and improved patient‑reported benefit.
- Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity
PubMed ID: 15982990
Acute Panax ginseng reduced subjective mental fatigue during sustained mental effort.
- Ginseng improves pulmonary functions and exercise capacity in patients with COPD
PubMed ID: 12814035
COPD patients had increased VO2max and exercise capacity after 3 months of G115 — consistent with increased functional energy.
- Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial
PubMed ID: 23613825
RDB trial in idiopathic chronic fatigue: Panax ginseng reduced mental fatigue scores and lowered oxidative‑stress markers — strong direct evidence.
- Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial
PubMed ID: 28753932
Red ginseng improved fatigue subscale of HRQL in chemotherapy survivors vs placebo — supports reduced fatigue in a clinical population.
- A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action
PubMed ID: 34396468
American ginseng produced acute and short‑term reductions in mental fatigue and improved self‑assurance in healthy adults.
- Xinyue Capsule in patients with stable coronary artery disease after percutaneous coronary intervention: a multicenter, randomized, placebo-controlled trial
PubMed ID: 32446979
Xinyue (Panax quinquefolius saponins) after PCI improved SF‑36 vitality scores at 12 months (patient‑reported energy/vitality improvement).
- A Phase II Randomized Controlled Trial of Renshen Yangrong Tang Herbal Extract Granules for Fatigue Reduction in Cancer Survivors
PubMed ID: 31668965
Multi‑herb formula that included ginseng produced clinically meaningful reductions in cancer‑related fatigue (ginseng may contribute but product not ginseng‑only).
- Anti-Fatigue Effects of Enzyme-Modified Ginseng Extract: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 27754709
Enzyme‑modified ginseng significantly reduced visual-analogue fatigue scores after 4 weeks in healthy adults.
- Adjuvant effects of fermented red ginseng extract on advanced non-small cell lung cancer patients treated with chemotherapy
PubMed ID: 26142337
Fermented red ginseng improved fatigue scores in lung cancer patients receiving chemotherapy—clinical fatigue benefit as adjunctive therapy.
- Effects of ginseng on peripheral blood mitochondrial DNA copy number and hormones in men with metabolic syndrome: A randomized clinical and pilot study
PubMed ID: 26860800
Red ginseng increased leukocyte mtDNA copy number and anabolic hormones—biomarkers consistent with increased cellular energy.
- Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2
PubMed ID: 23853057
Large phase III RCT showed statistically and clinically significant reduction in cancer‑related fatigue by 8 weeks.
- Ginseng in the treatment of fatigue in multiple sclerosis: a randomized, placebo-controlled, double-blind pilot study
PubMed ID: 23301896
3‑month RCT in MS showed significant reductions in fatigue (MFIS) and improved QoL.
Mental clarity (21)
- Effect of Hydroponically Grown Red Panax Ginseng on Perceived Stress Level, Emotional Processing, and Cognitive Functions in Moderately Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 40289951
Hydroponic red ginseng reduced stress and produced modest improvements on cognitive task measures in stressed adults.
- A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action
PubMed ID: 34396468
RDB trial of American ginseng showed robust improvements in attention accuracy, reaction time and reduced mental fatigue — strong direct evidence.
- Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial
PubMed ID: 23613825
In chronic fatigue, ginseng reduced mental fatigue and oxidative stress — may enhance mental clarity via reduced cognitive fatigue.
- [Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment]
PubMed ID: 17993008
Traditional herbal capsule including ginseng improved memory scores in MCI patients vs baseline — supports cognitive benefit (multi‑component).
- A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans
PubMed ID: 32731478
Multi‑ingredient beverage including ginseng acutely increased frontal O2 and improved some mood/fatigue measures — supports acute cognitive clarity.
- Effects of Korean red ginseng extract on behavior in children with symptoms of inattention and hyperactivity/impulsivity: a double-blind randomized placebo-controlled trial
PubMed ID: 25369174
Korean red ginseng modestly improved attention/hyperactivity scores and QEEG in children with ADHD symptoms.
- The cognitive, subjective, and physical effects of a ginkgo biloba/panax ginseng combination in healthy volunteers with neurasthenic complaints
PubMed ID: 9493479
90‑day Ginkgo/ ginseng combo produced dose‑related memory improvements in middle‑aged adults.
- The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers
PubMed ID: 11140327
Large RCT of Ginkgo/ginseng combo improved composite memory quality by ~7.5%.
- Effect of Memo®, a natural formula combination, on Mini-Mental State Examination scores in patients with mild cognitive impairment
PubMed ID: 23950642
4‑week triple‑natural formula (includes ginseng) increased MMSE by ~2 points in MCI.
- [A follow-up study on a randomized, single-blind control of King's Brain pills in treatment of memory disorder in elderly people with MCI in a Beijing community]
PubMed ID: 15620194
Compound ginseng product improved multiple memory test scores in elderly with mild cognitive impairment (but was multi‑herbal and single‑blind).
- Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity
PubMed ID: 15982990
Single doses of Panax ginseng improved sustained-attention task performance (Serial Sevens) and reduced mental fatigue acutely.
- Panax ginseng enhances cognitive performance in Alzheimer disease
PubMed ID: 18580589
Panax ginseng associated with short‑term cognitive improvements in Alzheimer's patients (open‑label adjunctive study).
- An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer's disease
PubMed ID: 18684311
High‑dose Korean red ginseng plus dementia meds improved ADAS and CDR scores over 12 weeks (open‑label adjunct).
- Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study
PubMed ID: 20676609
Standardized American ginseng produced acute, dose‑dependent improvements in memory and working memory in healthy adults.
- Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults
PubMed ID: 20737519
Acute single and 7‑day dosing produced modest improvements in calmness and some working‑memory/mental arithmetic in healthy young adults.
- HT1001, a proprietary North American ginseng extract, improves working memory in schizophrenia: a double-blind, placebo-controlled study
PubMed ID: 22213250
Standardized North American ginseng (HT1001) improved visual working memory in people with schizophrenia (4‑week RCT).
- Heat-processed ginseng enhances the cognitive function in patients with moderately severe Alzheimer's disease
PubMed ID: 22780999
Small RCT reported cognitive improvements (MMSE/ADAS) with heat‑processed ginseng in Alzheimer's patients.
- Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle-age adults
PubMed ID: 25778987
Single 200 mg American ginseng acutely improved working memory in middle-aged adults—direct human evidence for mental clarity.
- Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial
PubMed ID: 30309327
Shenmai injection (contains ginseng) was associated with better short‑term postoperative cognitive scores and lower neuronal injury biomarkers after cardiac surgery.
- Effects of Korean red ginseng on human gray matter volume and cognitive function: A voxel-based morphometry study
PubMed ID: 33217050
Eight‑week RCT showed increased parahippocampal GMV and modest cognitive score improvement with KRG in healthy adults (direct brain/memory structural & functional change).
- Efficacy and Safety of Panax ginseng Sprout Extract in Subjective Memory Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 38931306
Panax ginseng sprout extract improved verbal/visual memory and MoCA scores versus placebo in adults with memory complaints.
Healthy aging (17)
- A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults
PubMed ID: 14687309
CVT-E002 reduced influenza/RSV in institutionalized elderly—supports health protection in aging populations.
- The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study
PubMed ID: 34578969
Increases in mtDNA and antioxidant status with reduced fatigue in postmenopausal women support cellular healthy‑aging mechanisms.
- Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 34684351
12‑week ginseng extract increased bone‑formation markers in postmenopausal women with osteopenia (supports musculoskeletal healthy aging).
- Effect of Shengmai injection on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus
PubMed ID: 19082800
Shengmai injection markedly improved endothelial markers and EF in CHD with diabetes; endothelial health links to healthy aging (multi‑herb).
- Effects of ginseng on peripheral blood mitochondrial DNA copy number and hormones in men with metabolic syndrome: A randomized clinical and pilot study
PubMed ID: 26860800
Improvements in mitochondrial proxy, testosterone and IGF‑1 in metabolic‑syndrome men are biomarkers relevant to healthy aging.
- Impact of extended ginsenoside Rb1 on early chronic kidney disease: a randomized, placebo-controlled study
PubMed ID: 27853891
Rb1 improved renal function and reduced oxidative stress/inflammation in early CKD—organ-level benefit relevant to aging.
- Xinyue Capsule in patients with stable coronary artery disease after percutaneous coronary intervention: a multicenter, randomized, placebo-controlled trial
PubMed ID: 32446979
Large CV outcomes trial (reduced cardiac events) with Panax quinquefolius saponins supports long‑term cardiovascular health, a component of healthy aging.
- [A follow-up study on a randomized, single-blind control of King's Brain pills in treatment of memory disorder in elderly people with MCI in a Beijing community]
PubMed ID: 15620194
Memory improvements in elderly with MCI indicate potential healthy aging cognitive support, though study was multi‑herbal.
- Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial
PubMed ID: 28753932
Red ginseng lowered genotoxicity marker (micronucleus yield) and improved multiple HRQL domains — suggests cellular‑protective/aging relevance.
- Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial
PubMed ID: 23613825
Antioxidant marker improvements in chronic fatigue patients could support long‑term cellular health.
- Improvement of symptoms of aging in males by a preparation LEOPIN ROYAL containing aged garlic extract and other five of natural medicines - comparison with traditional herbal medicines (Kampo)
PubMed ID: 24844765
Multi‑ingredient product including ginseng improved Aging Males' Symptoms and erectile scores over 6 months (clinical aging‑related endpoints).
- The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers
PubMed ID: 11140327
Ginkgo/ginseng combo produced sustained composite memory improvement in middle‑aged adults—relevant to cognitive aging.
- The effect of Korean Red Ginseng on sarcopenia biomarkers in type 2 diabetes patients
PubMed ID: 32470863
24‑week KRG trial improved sarcopenia‑related biomarkers (follistatin, SHBG), relevant to age‑related muscle decline and healthy aging.
- Effect of Memo®, a natural formula combination, on Mini-Mental State Examination scores in patients with mild cognitive impairment
PubMed ID: 23950642
Memo (includes ginseng) increased MMSE in MCI patients over 4 weeks, suggesting short‑term cognitive benefit in aging.
- Influence of a double blind pharmacological trial on two domains of well-being in subjects with age associated memory impairment
PubMed ID: 15374200
9‑month ginseng‑containing vitamin complex improved memory index and life satisfaction in older adults.
- Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial
PubMed ID: 16566675
COLD-fX reduced incidence and duration of ARI in community-dwelling seniors—clinical protective effect for older adults.
- Panax ginseng enhances cognitive performance in Alzheimer disease
PubMed ID: 18580589
Cognitive improvements in Alzheimer's patients suggest potential support for age‑related cognitive decline (adjunctive open‑label evidence).
Sexual wellness (17)
- The enhancement of female sexual function with ArginMax, a nutritional supplement, among women differing in menopausal status
PubMed ID: 16959660
Larger randomized trial of ArginMax (contains ginseng) showed significant improvements in sexual desire and overall satisfaction in women — strong clinical support for sexual function (multi‑ingredient).
- Improvement of symptoms of aging in males by a preparation LEOPIN ROYAL containing aged garlic extract and other five of natural medicines - comparison with traditional herbal medicines (Kampo)
PubMed ID: 24844765
LER multi‑ingredient product (includes ginseng) improved Aging Males' Symptoms and IIEF‑5 erectile scores versus Kampo control (clinical improvement; multi‑herb).
- Clinical efficacy of Korean red ginseng for erectile dysfunction
PubMed ID: 8750052
Korean red ginseng produced greater partial improvements in erectile function, rigidity, girth and libido versus placebo (RCT).
- A double-blind crossover study evaluating the efficacy of korean red ginseng in patients with erectile dysfunction: a preliminary report
PubMed ID: 12394711
Korean red ginseng significantly improved IIEF scores and penile rigidity vs placebo in men with ED — good clinical evidence for sexual vitality.
- Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction
PubMed ID: 16855773
Korean red ginseng produced clinically meaningful increases in IIEF‑5 and a majority reported improved erections in men with mild‑moderate ED.
- Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction
PubMed ID: 19234482
Tissue‑cultured mountain ginseng extract improved IIEF erectile function and satisfaction vs placebo in an 8‑week RCT.
- Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study
PubMed ID: 20141583
Korean red ginseng modestly improved sexual arousal scores in menopausal women in a small placebo‑controlled crossover trial.
- Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study
PubMed ID: 23254461
Multicenter RCT of ginseng berry extract showed modest but statistically significant improvements in erectile and sexual function scores.
- Effects of ginseng on peripheral blood mitochondrial DNA copy number and hormones in men with metabolic syndrome: A randomized clinical and pilot study
PubMed ID: 26860800
Red ginseng increased total testosterone and IGF‑1 in men with metabolic syndrome—hormonal improvements relevant to sexual vitality.
- Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study
PubMed ID: 25967606
Korean red ginseng improved sperm concentration, motility and morphology in infertile men in a randomized, double‑blind trial—strong sexual‑health signal.
- The effect of ginseng on sexual dysfunction in menopausal women: A double-blind, randomized, controlled trial
PubMed ID: 31331583
Double‑blind RCT: Panax ginseng significantly improved female sexual function (FSFI) and menopause‑related QoL in postmenopausal women—strong direct evidence.
- The Effect of Panax ginseng on Genitourinary Syndrome in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 33730722
Four‑week Panax ginseng RCT improved women's self‑reported vaginal atrophy symptoms (subjective sexual/mucosal vitality improvement).
- Ginseng treatment improves the sexual side effects of methadone maintenance treatment
PubMed ID: 31082749
Ginseng extract improved self‑reported sexual function in methadone‑maintained patients in an RCT—positive short‑term evidence.
- A new original nutraceutical formulation ameliorates the effect of Tadalafil on clinical score and cGMP accumulation
PubMed ID: 34286560
Panax ginseng‑containing supplement added to tadalafil produced greater erectile function improvement and increased platelet cGMP (direct sexual function benefit).
- [Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia]
PubMed ID: 20940690
Multi‑ingredient supplement containing ginseng improved sperm motility and sexual satisfaction vs untreated controls — supports male sexual/reproductive outcomes (combination product).
- Semen quality in patients with Chlamydia trachomatis genital infection treated concurrently with prulifloxacin and a phytotherapeutic agent
PubMed ID: 21979301
Multi‑herbal adjunct (including ginseng) given to men with chronic prostatitis improved sperm concentration and motility — clinically meaningful reproductive improvements.
- A double-blind placebo-controlled study of ArginMax, a nutritional supplement for enhancement of female sexual function
PubMed ID: 11554217
ArginMax (includes ginseng) improved multiple measures of female sexual function vs placebo in an RCT — supports sexual vitality (attributable to combination product).
Respiratory comfort (16)
- [Effects of sheng mai injection on thoracoabdominal motion]
PubMed ID: 8334346
Sheng Mai injection (contains ginseng) rapidly normalized thoracoabdominal motion in COPD patients (high responder rate).
- Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold [corrected]
PubMed ID: 8879982
G115 markedly reduced winter respiratory infections and symptoms vs placebo — clinically meaningful respiratory protection.
- [Effect of shenmai injection on diaphragmatic fatigue in children with respiratory failure]
PubMed ID: 12585186
Shengmai injection produced rapid clinical improvement, diaphragmatic fatigue relief and better gas exchange in children with respiratory failure — strong effect in acute setting.
- [Effects of Yiqi Huoxue Jiedu formula on the gut microbiota in elderly patients with pulmonary-derived sepsis based on 16S rDNA sequencing: a multicenter prospective randomized double-blind controlled trial]
PubMed ID: 40819941
YHJF (includes Panax ginseng) improved clinical indices in pulmonary-derived sepsis and altered gut–lung associated microbiota (multi‑herb trial).
- Correction of hypoxic effects on target organs in pneumonia with phytotherapy
PubMed ID: 39681530
Ginseng-containing phytopreparation improved some hypoxia-related respiratory parameters and oxygen saturation in pneumonia patients.
- Effects of Shengmai Yin on pulmonary and cardiac function in coronavirus disease 2019 convalescent patients with cardiopulmonary symptoms: a randomized, double blind, multicenter control trial
PubMed ID: 36640005
Shengmai Yin modestly improved chest‑distress in COVID‑19 convalescent patients (direct respiratory symptom relief).
- The Effect of Korean Red Ginseng on Symptoms and Inflammation in Patients With Allergic Rhinitis
PubMed ID: 32070136
KRG improved allergic rhinorrhea, nasal/eye itching and reduced nasal eosinophils/IL‑4 in allergic rhinitis—direct symptomatic respiratory benefit in upper airway allergy.
- Effect of two administration routes of Shenmai Injection () on pulmonary gas exchange function after tourniquet-induced ischemia-reperfusion
PubMed ID: 27299461
IV Shenmai preserved pulmonary gas exchange and lowered inflammatory markers after limb ischemia‑reperfusion—clinical respiratory-protective signal.
- Preventive effect of Korean red ginseng for acute respiratory illness: a randomized and double-blind clinical trial
PubMed ID: 23255845
KRG reduced incidence of acute respiratory illness (clinical respiratory benefit).
- [Effect and significance of Shenmai injection on value of vascular endothelial active factors of heart valve replacement patients]
PubMed ID: 19685757
Shenmai injection attenuated post‑CPB rises in ET‑1 and improved P(A‑a)DO2/RI, indicating respiratory benefit (multi‑component).
- [Protective effect of Shenmai injection on lung injury induced by cardiac pulmonary bypass]
PubMed ID: 19673331
Perioperative Shenmai infusion (contains ginseng) reduced lung injury markers and improved oxygenation after CPB (small RCT, multi‑component).
- Ginseng improves pulmonary functions and exercise capacity in patients with COPD
PubMed ID: 12814035
Randomized trial in moderate–severe COPD showed large, consistent improvements in FEV1, VO2max and exercise capacity — strong respiratory benefit.
- Effects of a new nutraceutical ingredient on allergen-induced sulphidoleukotrienes production and CD63 expression in allergic subjects
PubMed ID: 18817894
Mixed‑plant product containing Panax reduced leukotriene production and basophil activation (CD63) in allergic subjects—biomarkers relevant to respiratory allergy/inflammation.
- [Effects of shenmai injection on the clinical efficacy of noninvasive ventilation in patients with severe respiratory failure caused by chronic obstructive pulmonary disease]
PubMed ID: 16983914
Shenmai injection added to NPPV in severe COPD shortened ventilation and hospitalization times and improved arterial blood gases and dyspnea scores.
- Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial
PubMed ID: 16566675
COLD-fX reduced ARI incidence and shortened symptom duration in seniors—clinical respiratory benefit.
- Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial
PubMed ID: 16247099
North American ginseng extract reduced common cold incidence/severity/duration—supports respiratory symptom reduction.
Digestive support (13)
- Effect of Daikenchuto, a Traditional Japanese Herbal Medicine, after Total Gastrectomy for Gastric Cancer: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase II Trial
PubMed ID: 26141466
Large RCT: DKT modestly sped bowel recovery after gastrectomy, especially in adherent patients—clinical digestive support.
- Daikenchuto stimulates colonic motility after laparoscopic-assisted colectomy
PubMed ID: 24895799
Daikenchuto (includes ginseng) shortened time to flatus/bowel movement after colectomy (clinically meaningful but multi‑herb).
- The effects of the Kampo medicine (Japanese herbal medicine) "Daikenchuto" on the surgical inflammatory response following laparoscopic colorectal resection
PubMed ID: 22202972
Daikenchuto (multi‑herb including ginseng) shortened time to first flatus and lowered postoperative CRP after colorectal surgery.
- [Effect of Shenfu injection in postoperative recovery after abdominal surgery]
PubMed ID: 17455472
Shenfu injection shortened time to first flatus after abdominal surgery, a direct digestive/recovery benefit.
- Effect of daikenchuto (TU-100) on gastrointestinal and colonic transit in humans
PubMed ID: 20378829
TU‑100 (contains ginseng) accelerated ascending colon emptying in healthy humans at higher dose.
- The beneficial effects of Kampo medicine Dai-ken-chu-to after hepatic resection: a prospective randomized control study
PubMed ID: 23435143
Dai‑kenchu‑to (Kampo mix that can include ginseng) shortened time to first flatus/bowel movement and reduced postoperative inflammation after liver resection.
- Combination of Panax notoginseng saponins and aspirin potentiates platelet inhibition with alleviated gastric injury via modulating arachidonic acid metabolism
PubMed ID: 33370633
PNS + aspirin reduced aspirin‑related gastric symptoms (improved SODA dyspepsia scores) — direct improvement in digestive comfort.
- Evaluation of TU-100 (Daikenchuto), a Traditional Japanese Kampo Medicine, as an Adjunct to Enhanced Recovery After Surgery, for Acceleration of Gastrointestinal Recovery After Bowel Resection: Results of a Proof-of-Concept, Phase 2, Randomized, Double-Blinded, Placebo-Controlled Trial
PubMed ID: 41114550
TU-100 (contains ginseng) modestly accelerated GI recovery, reduced LOS and nausea in post‑resection patients.
- Effect of herbal medicine daikenchuto on oral and enteral caloric intake after liver transplantation: A multicenter, randomized controlled trial
PubMed ID: 29747091
Daikenchuto after liver transplant accelerated oral/enteral intake and increased portal flow (secondary digestive/recovery signals).
- Effects of daikenchuto, a Japanese herb, on intestinal motility after total gastrectomy: a prospective randomized trial
PubMed ID: 25564322
Daikenchuto (contains ginseng) after gastrectomy increased stool frequency/form and reduced abdominal gas—clear digestive benefit (multi-herb product).
- Efficacy of the Panax Notoginseng Ejiao Suppository in the Treatment of Patients with Ulcerative Proctitis and Its Effect on Inflammatory Response and Immune Function
PubMed ID: 36188425
Panax notoginseng–Ejiao suppository improved symptoms and reduced recurrence in ulcerative proctitis (direct GI symptom/inflammation improvement).
- Effects of Daikenchuto on postoperative gastrointestinal motility in colorectal carcinoma patients with abdominal pain and distension: a prospective, randomized trial
PubMed ID: 32588153
Perioperative Daikenchuto (multi‑herb including ginseng) reduced bowel movements and incomplete evacuation after colorectal surgery (direct digestive symptom benefit).
- Responder Analysis of Daikenchuto Treatment for Constipation in Poststroke Patients: A Subanalysis of a Randomized Control Trial
PubMed ID: 31823650
Daikenchuto (contains ginseng) produced large, significant improvements in constipation scores and reduced intestinal gas after stroke.
Antioxidant (13)
- Effects of shenmai injection on blood SOD activity and MDA level in senile patients with coronary heart disease
PubMed ID: 15889524
Shenmai (contains ginseng) increased SOD activity and decreased MDA in elderly coronary heart disease patients—direct antioxidant marker changes.
- [Effect of combined therapy of shenmai and compound danshen injection on myocardial reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction]
PubMed ID: 15250199
Shenmai (contains ginseng) preserved SOD and lowered MDA after PCI (human clinical data).
- Impact of extended ginsenoside Rb1 on early chronic kidney disease: a randomized, placebo-controlled study
PubMed ID: 27853891
Extended Rb1 treatment reduced oxidative stress markers in early CKD patients—clinical antioxidant signal.
- [Effect of Shenmai Injection on Vascular Endothelial Dependence Diastolic Function in Coronary Heart Disease Patients]
PubMed ID: 30650479
Shenmai (contains ginseng) increased SOD and improved NO/oxidative marker profile—supports antioxidant action (multi‑component product).
- Cardioprotection of Shenfu Injection against myocardial ischemia/reperfusion injury in open heart surgery
PubMed ID: 18568324
Shenfu regimen decreased MDA and increased SOD in small perioperative group (multi‑component injection).
- Antioxidant effects of Panax ginseng C.A. Meyer in healthy subjects: a randomized, placebo-controlled clinical trial
PubMed ID: 21699953
Placebo-controlled trial in healthy volunteers showing decreased ROS/MDA and increased glutathione and GSH‑Rd with 2 g/day Panax ginseng.
- Beneficial effects of Korean red ginseng on lymphocyte DNA damage, antioxidant enzyme activity, and LDL oxidation in healthy participants: a randomized, double-blind, placebo-controlled trial
PubMed ID: 22805313
Large RCT showed increased SOD/GPx/catalase and reduced oxidized LDL and DNA oxidative damage.
- Antioxidative effects of Korean red ginseng in postmenopausal women: a double-blind randomized controlled trial
PubMed ID: 24814037
12‑week RCT increased SOD activity in postmenopausal women (biomarker signal).
- The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study
PubMed ID: 34578969
Twelve-week RCT showed increased total antioxidant status (TAS) and mtDNA in KRG users (direct antioxidant biomarker change).
- The effect of Tianjiang Xueshuantong Wan pills on ischemia-reperfusion injury after thrombolysis in acute cerebral infarction
PubMed ID: 35246395
Post‑thrombolysis trial reported increased SOD and decreased MDA (antioxidant/reperfusion marker improvements) with a Panax-containing formula.
- [Effect of Shenfu injection in postoperative recovery after abdominal surgery]
PubMed ID: 17455472
Shenfu injection raised SOD and lowered MDA after surgery, indicating antioxidant effects (multi-component product).
- Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial
PubMed ID: 23613825
RDB trial showed decreased ROS and MDA and increased GSH activity with Panax ginseng — direct antioxidant biomarker improvements.
- Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial
PubMed ID: 28753932
Red ginseng reduced micronucleus yield (less genotoxicity) — consistent with antioxidant/protective effects.
Focus & concentration (13)
- Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity
PubMed ID: 15982990
Acute Panax ginseng improved a sustained-attention subtraction task and reduced mental fatigue.
- Efficacy of Omega-3 and Korean Red Ginseng in Children with Subthreshold ADHD: A Double-Blind, Randomized, Placebo-Controlled Trial
PubMed ID: 32847461
Omega‑3 plus Korean red ginseng improved ADHD symptom scores and attention measures in children (combination product).
- Effects of Korean red ginseng extract on behavior in children with symptoms of inattention and hyperactivity/impulsivity: a double-blind randomized placebo-controlled trial
PubMed ID: 25369174
Korean red ginseng produced statistically significant improvements in inattention and EEG TBR in children with ADHD symptoms.
- A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans
PubMed ID: 32731478
Beverage with ginseng increased frontal oxygenation and improved some alertness/mental fatigue measures — supports acute focus.
- [Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment]
PubMed ID: 17993008
Herbal capsule including ginseng improved memory and related cognitive measures in older adults — relevant to attentional performance.
- A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action
PubMed ID: 34396468
American ginseng improved sustained and executive attention outcomes in an RCT — clear support for improved focus.
- Heat-processed ginseng enhances the cognitive function in patients with moderately severe Alzheimer's disease
PubMed ID: 22780999
Cognitive test improvements in Alzheimer's suggest benefits for attention/focus in that population.
- Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle-age adults
PubMed ID: 25778987
Working-memory improvements in a crossover study imply improved short-term focus after American ginseng.
- Effects of Korean red ginseng on human gray matter volume and cognitive function: A voxel-based morphometry study
PubMed ID: 33217050
KRG produced modest composite cognitive improvements (attention/executive domains included), supporting focus benefits.
- Efficacy and Safety of Panax ginseng Sprout Extract in Subjective Memory Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 38931306
Cognitive trial showed memory and global cognition gains which support improved attentional function.
- HT1001, a proprietary North American ginseng extract, improves working memory in schizophrenia: a double-blind, placebo-controlled study
PubMed ID: 22213250
HT1001 improved visual working memory in schizophrenia, indicating meaningful cognitive/attention benefit in that population.
- Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study
PubMed ID: 20676609
Acute standardized American ginseng reliably improved working memory speed and attention measures in healthy adults.
- The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers
PubMed ID: 11140327
Ginkgo/ginseng combo improved working memory and contributed to composite memory gains (attention component).
Blood sugar (11)
- Supplementation of cheonggukjang and red ginseng cheonggukjang can improve plasma lipid profile and fasting blood glucose concentration in subjects with impaired fasting glucose
PubMed ID: 21128827
Red ginseng–enriched product lowered fasting blood glucose in subjects with impaired fasting glucose over 8 weeks (small RCT).
- [Effect of Tangyikang in improving the function of pancreatic islet beta cells in patients with latent autoimmune diabetes mellitus in adults]
PubMed ID: 19123322
In LADA patients a multi‑herb decoction including red ginseng improved beta‑cell function and reduced insulin dose requirements (human clinical signal).
- Diabetes-ameliorating effects of fermented red ginseng and causal effects on hormonal interactions: testing the hypothesis by multiple group path analysis
PubMed ID: 23675990
Two‑week fermented red ginseng in postmenopausal women modestly reduced HbA1c, insulin and HOMA‑IR (statistically significant but small effects).
- [Effect of panax quinquefolius saponin on insulin sensitivity in patients of coronary heart disease with blood glucose abnormality]
PubMed ID: 18198636
Panax quinquefolius saponin improved HOMA‑beta (beta‑cell function) and was associated with glucose changes in CHD patients with abnormal glucose (adjunct therapy).
- [Effect of renshen jianxin capsule for alleviating insulin resistance in patients with coronary heart disease and glucose tolerance impairment]
PubMed ID: 19960983
Renshen Jianxin Capsule (ginseng‑based) improved insulin sensitivity measures over 20 weeks, comparable to metformin in CHD patients with IGT.
- Effects of Panax notoginseng (Chinese ginseng) and acute exercise on postprandial glycemia in non-diabetic adults
PubMed ID: 22499718
Short‑term PNG lowered early postprandial glucose and 0–90 min AUC in healthy men (acute glycemic effect).
- Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 25015735
4‑week RCT in impaired glucose regulation showed significant 2‑h postprandial glucose and AUC reductions and increased insulin.
- Korean red ginseng improves glucose control in subjects with impaired fasting glucose, impaired glucose tolerance, or newly diagnosed type 2 diabetes mellitus
PubMed ID: 24456363
12‑week RCT in IFG/IGT/new T2DM lowered early post‑load glucose (30 min) with trends for AUC reduction.
- Effects of Shenlian formula on microbiota and inflammatory cytokines in adults with type 2 diabetes: a double-blind randomized clinical trial
PubMed ID: 37454261
Shenlian formula (Huanglian + Renshen) produced significant reductions in postprandial glucose, HOMA‑IR and CRP over 12 weeks (direct glycemic/improvement evidence).
- Effects of ginseng berry saponins from panax ginseng on glucose metabolism of patients with prediabetes: A randomized, double-blinded, placebo-controlled, crossover trial
PubMed ID: 39004031
Ginseng-berry saponins reduced 2‑h postprandial glucose and improved HOMA-IR in prediabetes (well-powered RCT crossover).
- Efficacy and safety of red ginseng extract powder (KGC05pg) in achieving glycemic control in prediabetic Korean adults: A 12-week, single-center, randomized, double-blind, parallel-group, placebo-controlled study
PubMed ID: 39969290
Korean red ginseng extract modestly improved fasting/postprandial glucose and insulin-resistance markers in prediabetic adults.
Endurance (5)
- The utility of traditional Chinese medicine (Shenmai) in the cardiac rehabilitation after coronary artery bypass grafting: A single-center randomized clinical trial
PubMed ID: 31779994
Shenmai (includes ginseng) led to a clinically meaningful ~43 m greater 6‑minute walk distance at discharge—strong signal for short‑term stamina.
- A randomized, double-blind, multicenter, placebo-controlled clinical study on the efficacy and safety of Shenmai injection in patients with chronic heart failure
PubMed ID: 27045864
Shenmai injection improved 6MWD and NYHA class in heart‑failure patients over one week—improved short‑term stamina/function as adjunct.
- Ginseng improves pulmonary functions and exercise capacity in patients with COPD
PubMed ID: 12814035
G115 produced large VO2max and exercise capacity gains in COPD patients — strong endurance benefit in disease population.
- [Clinical study in treating qi-deficiency and blood-stasis syndrome of angina pectoris with qi xue granule]
PubMed ID: 1301847
Ginseng‑containing formula increased exercise time and workload (~30% increases) in angina patients.
- Efficacy and Safety of Panax notoginseng Saponins in the Treatment of Adults With Ischemic Stroke in China: A Randomized Clinical Trial
PubMed ID: 37338907
Large ischemic stroke trial with Panax notoginseng saponins improved functional independence at 3 months, plausibly reflecting increased activity/endurance capacity.
Mood balance (8)
- Neurocognitive effects a combined polyphenolic-rich herbal extract in healthy middle-aged adults - a randomised, double-blind, placebo-controlled study
PubMed ID: 38512715
Multi‑ingredient supplement including Panax improved positive affect and delayed recall vs placebo after 28 days (clinical mood outcome).
- Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial
PubMed ID: 28753932
Red ginseng improved emotional function and anxiety subscales of HRQL in chemo patients — supports mood enhancement in a clinical context.
- Influence of a double blind pharmacological trial on two domains of well-being in subjects with age associated memory impairment
PubMed ID: 15374200
9‑month ginseng‑containing vitamin complex improved self‑reported life satisfaction (mood/quality‑of‑life) in older adults.
- A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action
PubMed ID: 34396468
American ginseng improved subjective self‑assurance and reduced mental fatigue in RCT — indicates modest mood/affect benefit.
- Effects of sun ginseng on subjective quality of life in cancer patients: a double-blind, placebo-controlled pilot trial
PubMed ID: 16882101
Sun ginseng improved psychological QoL and GHQ‑12 scores in cancer patients indicating better mental health/mood.
- Safety and efficacy of Ninjin'yoeito along with iron supplementation therapy for preoperative anemia, fatigue, and anxiety in patients with gynecological disease: an open-label, single-center, randomized phase-II trial
PubMed ID: 35701778
Ninjin'yoeito + iron reduced anxiety VAS more than iron alone (direct mood/anxiety improvement).
- Effects of Panax Ginseng on Health-Related Quality of Life in Patients with Non-Metastatic Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Ginseng for HRQOL in Breast Cancer
PubMed ID: 37218691
Prevention of decline in emotional well‑being during chemotherapy supports mood benefit (small RCT).
- Effect of Hydroponically Grown Red Panax Ginseng on Perceived Stress Level, Emotional Processing, and Cognitive Functions in Moderately Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 40289951
Hydroponic red ginseng reduced negative affect (PANAS‑N) and perceived stress in a randomized trial.
Stress & Anxiety (5)
- Effects of ginseng on peripheral blood mitochondrial DNA copy number and hormones in men with metabolic syndrome: A randomized clinical and pilot study
PubMed ID: 26860800
Red ginseng lowered serum cortisol in metabolic‑syndrome men—objective marker of reduced physiological stress.
- Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial
PubMed ID: 28753932
Red ginseng improved emotional function and anxiety subscales of HRQL in chemo patients — supports stress/anxiety symptom relief.
- Effect of Hydroponically Grown Red Panax Ginseng on Perceived Stress Level, Emotional Processing, and Cognitive Functions in Moderately Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 40289951
Hydroponic red ginseng significantly reduced perceived stress (PSS) and negative affect versus placebo in moderately stressed adults.
- Effects of Panax Ginseng on Health-Related Quality of Life in Patients with Non-Metastatic Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Ginseng for HRQOL in Breast Cancer
PubMed ID: 37218691
Improvement/preservation of emotional well‑being during chemotherapy indicates stress-related QoL benefit (small RCT).
- Safety and efficacy of Ninjin'yoeito along with iron supplementation therapy for preoperative anemia, fatigue, and anxiety in patients with gynecological disease: an open-label, single-center, randomized phase-II trial
PubMed ID: 35701778
NYT (contains ginseng) plus iron reduced anxiety (VAS‑A) more than iron alone in preop patients (direct stress/anxiety relief).
Sleep quality (2)
- Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial
PubMed ID: 28753932
Red ginseng improved the sleep subscale of HRQL in chemotherapy survivors vs placebo — evidence for improved sleep quality in this population.
- Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study
PubMed ID: 17454163
3‑month multi‑herb formula including American ginseng markedly reduced hot flushes/night sweats and improved sleep quality in menopausal women (randomized double‑blind).
Skin health (1)
- Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin: a randomized, double-blind, placebo-controlled study
PubMed ID: 20041778
24‑week RCT of a red ginseng‑containing herbal mixture reduced facial wrinkles and increased type I procollagen expression vs placebo (objective skin outcomes; multi‑herb).
Weight management (1)
- Effects of Shenlian formula on microbiota and inflammatory cytokines in adults with type 2 diabetes: a double-blind randomized clinical trial
PubMed ID: 37454261
Shenlian formula decreased BMI over 12 weeks in T2DM patients (direct modest weight/BMI effect).
Similar by evidence
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Products with Ginseng
Search all2156 products whose verified label declares Ginseng — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.