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Ginseng

18 benefits mapped to clinical evidence across supplements.

Dose per serving from products

906 products in our catalogue print how much Ginseng a serving holds.

Most common: 50 mg to 100 mg, 24% of 906 products.

Dose per servingProducts
2.5 mg or less
23
2.5 mg to 5 mg
50
5 mg to 10 mg
18
10 mg to 25 mg
167
25 mg to 50 mg
210
50 mg to 100 mg
216
100 mg to 250 mg
112
250 mg to 500 mg
47
500 mg to 1 g
36
over 1 g
27

Dose per serving from research

77 study groups in 44 studies say how much Ginseng participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 g to 5 g, 38% of 77 study groups.

Daily doseStudy groups
100 mg or less
4
100 mg to 250 mg
10
250 mg to 500 mg
12
500 mg to 1 g
10
1 g to 2.5 g
10
2.5 g to 5 g
29
over 5 g
2

See every study group

Benefit Evidence

Inflammation/symptoms recovery

Blood loss −3.4pp

Function/quality-of-life recovery

7,650 people

Platelets/vasoconstriction ↓

BP/stiffness ↓

Circulation/function ↑

8,819 people

Immune boost: IgA, T-cells

+35% NK/Phagocytosis

Inflammation down, immunity up

3,114 people

Fatigue ↓, cognition ↑

Exercise capacity ↑, fatigue ↓

Biomarkers improved, fatigue ↓

2,949 people

Attention/memory +1.25d

Fatigue/stress ↓

Global cognition +2pt

1,640 people

Cognition/memory +2 points

Fatigue/oxidative stress less

Respiratory/cardiac events down

2,593 people

Erectile function +7

Desire/satisfaction +6

Sperm motility +13%

1,533 people

Symptom/infection reduction

Breathing/gas exchange improvement

1,437 people

Digestive recovery +flatus

Less symptoms, gas

Bowel motility +1 day

1,303 people
Antioxidant
Moderate

Oxidative stress ↓

+SOD / +TAS

Fatigue ↓ 7

1,081 people

Attention/fatigue +1.25

Memory/working memory +7.5%

1,054 people
Blood sugar
Moderate

PPG ↓ 18-39%

Insulin sens ↑; HbA1c ↓

FBG/2h glucose ↓

835 people
Endurance
Moderate

Endurance: ↑20%

Exercise tolerance: +30%

3,625 people
Mood balance
Moderate

Mood/stress ↓, +4.3

Fatigue/anxiety ↓, +2.2 g/dL

475 people

Stress/anxiety ↓ PSS, VAS-A

Cortisol↓ HRV↑, anxiety↓

311 people

Improved sleep; +73% hot flushes

Sleep improved; MN 5.7→1.4

80 people

Wrinkle reduction; collagen↑

Eye wrinkles, roughness↓

82 people

BMI −0.61

PBG/IR/CRP down

31 people

Research sources

Illness recovery (44)
  1. Effect of two administration routes of Shenmai Injection () on pulmonary gas exchange function after tourniquet-induced ischemia-reperfusion

    PubMed ID: 27299461

    IV Shenmai protected lungs and lowered inflammatory markers after ischemia‑reperfusion—supportive of organ recovery mitigation.

  2. The effects of the herbal medicine Daikenchuto (TJ-100) after esophageal cancer resection, open-label, randomized controlled trial

    PubMed ID: 29892933

    TJ‑100 (contains ginseng) significantly reduced postoperative weight loss and tended to lessen inflammation after esophagectomy—strong recovery signal (multi‑herb).

  3. Effect of herbal medicine daikenchuto on oral and enteral caloric intake after liver transplantation: A multicenter, randomized controlled trial

    PubMed ID: 29747091

    Daikenchuto accelerated postoperative oral intake and improved portal flow after liver transplant—benefit for postoperative recovery (contains ginseng).

  4. The utility of traditional Chinese medicine (Shenmai) in the cardiac rehabilitation after coronary artery bypass grafting: A single-center randomized clinical trial

    PubMed ID: 31779994

    Shenmai added to cardiac rehab increased early discharge 6MWD—improves early functional recovery (multi‑ingredient product).

  5. Effects of Daikenchuto on postoperative gastrointestinal motility in colorectal carcinoma patients with abdominal pain and distension: a prospective, randomized trial

    PubMed ID: 32588153

    Perioperative Daikenchuto reduced postoperative bowel symptoms (supports post‑surgical recovery of bowel function).

  6. Korean red ginseng for cancer-related fatigue in colorectal cancer patients with chemotherapy: A randomised phase III trial

    PubMed ID: 32172198

    KRG reduced chemotherapy‑related fatigue and improved QoL domains—facilitates recovery/functional status during treatment.

  7. Prophylactic efficacy of ninjin'yoeito for oxaliplatin-induced cumulative peripheral neuropathy in patients with colorectal cancer receiving postoperative adjuvant chemotherapy: a randomized, open-label, phase 2 trial (HOPE-2)

    PubMed ID: 32232692

    Ninjin'yoeito (contains ginseng) markedly reduced oxaliplatin cumulative neuropathy and preserved chemo dosing (helps recovery/continuation of therapy).

  8. Efficacy of the Panax Notoginseng Ejiao Suppository in the Treatment of Patients with Ulcerative Proctitis and Its Effect on Inflammatory Response and Immune Function

    PubMed ID: 36188425

    Panax notoginseng–Ejiao suppository lowered inflammation and reduced recurrence in ulcerative proctitis (improves symptom recovery and relapse prevention).

  9. Protective effects of Panax ginseng against doxorubicin-induced cardiac toxicity in patients with non-metastatic breast cancer: A randomized, double-blind, placebo-controlled clinical trial

    PubMed ID: 35975564

    Adjunctive Panax ginseng reduced anthracycline cardiotoxicity and preserved LVEF during chemo (supports recovery and organ protection during therapy).

  10. Efficacy and Safety of Panax notoginseng Saponins in the Treatment of Adults With Ischemic Stroke in China: A Randomized Clinical Trial

    PubMed ID: 37338907

    Large double‑blind RCT: Panax notoginseng saponins increased proportion functionally independent after ischemic stroke (strong recovery/outcome benefit).

  11. Effects of Panax Ginseng on Health-Related Quality of Life in Patients with Non-Metastatic Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Ginseng for HRQOL in Breast Cancer

    PubMed ID: 37218691

    Panax ginseng prevented declines in physical well‑being during chemotherapy, indicating support for recovery/function in treatment period.

  12. Ginseng Berry Concentrate Alleviates Fatigue in Humans: A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial

    PubMed ID: 41022533

    Antifatigue effects and lower lactic acid suggest support for recovery from exertional or chronic fatigue states.

  13. Evaluation of TU-100 (Daikenchuto), a Traditional Japanese Kampo Medicine, as an Adjunct to Enhanced Recovery After Surgery, for Acceleration of Gastrointestinal Recovery After Bowel Resection: Results of a Proof-of-Concept, Phase 2, Randomized, Double-Blinded, Placebo-Controlled Trial

    PubMed ID: 41114550

    TU-100 (contains ginseng) shortened hospital stay and modestly accelerated GI recovery after bowel resection (large trial; primary endpoint not met).

  14. Safety and efficacy of Ninjin'yoeito along with iron supplementation therapy for preoperative anemia, fatigue, and anxiety in patients with gynecological disease: an open-label, single-center, randomized phase-II trial

    PubMed ID: 35701778

    Ninjin'yoeito plus iron improved preoperative anemia correction and reduced fatigue/anxiety—supports perioperative recovery and readiness.

  15. A new way: alleviating postembolization syndrome following transcatheter arterial chemoembolization

    PubMed ID: 19216654

    Ginsenosides + dexamethasone reduced post‑embolization symptoms and improved liver enzymes after TACE — supports symptomatic recovery.

  16. [Effect of rhubarb as the main composition of sequential treatment in patients with acute paraquat poisoning: a prospective clinical research]

    PubMed ID: 25891453

    Sequential Western+TCM regimen including ginseng hastened toxin elimination and shortened hospital stay in paraquat poisoning (multi‑herbal protocol) — recovery benefit though attribution to ginseng is weak.

  17. Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial

    PubMed ID: 28753932

    Red ginseng improved HRQL and reduced genotoxicity in chemo patients during recovery from chemotherapy‑related damage.

  18. Improvement of hematoma absorption and neurological function in patients with acute intracerebral hemorrhage treated with Xueshuantong

    PubMed ID: 23062408

    Xueshuantong (Panax notoginseng components) accelerated hematoma absorption and improved neurologic scores after ICH — clear recovery‑related benefit.

  19. [Effect of cellular immune supportive treatment on immunity of esophageal carcinoma patients after modern two-field lymph node dissection]

    PubMed ID: 17626759

    Perioperative Shenqi injection (contains ginseng) improved early postoperative cellular immunity markers, supportive of surgical recovery.

  20. [Effects of Hengyan medicinal recipe on the regulation of immunity in patients with severe sepsis: a prospective clinical trial]

    PubMed ID: 21315002

    Severe sepsis patients given multi‑herb including red ginseng showed lower IL‑6/TNF and higher CD4+ counts at day 7—supports acute recovery of immune function.

  21. Effects of Astragalus membranaceus and Panax notoginseng Saponins Extract on the Pharmacokinetics of Whey Protein Absorption, Intestinal Permeability, and Muscle Function: A Pilot Study

    PubMed ID: 41683325

    Panax+Astragalus saponin extract increased BCAA absorption, modestly increased muscle mass and grip strength over 4 weeks—supports nutritional recovery and muscle rebuilding.

  22. The beneficial effects of Kampo medicine Dai-ken-chu-to after hepatic resection: a prospective randomized control study

    PubMed ID: 23435143

    Dai‑kenchu‑to shortened time to gastrointestinal recovery (flatus/bowel movements) after liver surgery—clinical recovery metric (multi‑ingredient product).

  23. [The effect of salvia miltiorrhiza and shengmai on inflammatory mediator and renal function of post-operative patients with obstructive jaundice]

    PubMed ID: 12528557

    Shengmai‑containing therapy lowered inflammatory mediators and improved renal markers after surgery (supports recovery; multi‑herb).

  24. [Effect of combined therapy of shenmai and compound danshen injection on myocardial reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction]

    PubMed ID: 15250199

    Shenmai + danshen reduced inflammatory markers and improved early cardiac function after AMI (supports peri‑procedural recovery).

  25. [Protective effects of ginsenoside on myocardiac ischemic and reperfusion injuries]

    PubMed ID: 7842343

    Ginsenosides used during cardioplegia improved postoperative cardiac function/ultrastructure (supports recovery).

  26. [Effects of Shenmai injection on immune function in stomach cancer patients after chemotherapy]

    PubMed ID: 8580688

    Shenmai injection (contains ginseng) aided immune recovery after chemotherapy in stomach cancer patients.

  27. [Study on effect of shenmai injection in protecting myocardium against ischemia-reperfusion injury in thrombolytic therapy with urokinase for acute myocardial infarction patients evaluated by 99mTc-MIBI myocardial imaging]

    PubMed ID: 12577392

    Adjunctive Shengmai therapy after thrombolysis reduced ischemic area and improved EF — supports myocardial recovery (multi‑herb intervention).

  28. Ginseng improves pulmonary functions and exercise capacity in patients with COPD

    PubMed ID: 12814035

    Improved pulmonary function and exercise capacity in COPD implies enhanced recovery/functional status over 3 months.

  29. [Effect of shenmai injection on diaphragmatic fatigue in children with respiratory failure]

    PubMed ID: 12585186

    Rapid clinical improvement and diaphragmatic fatigue resolution in pediatric respiratory failure with Shengmai injection — strong recovery signal in acute care context.

  30. [Clinical observation on effect of xuesaitong injection as auxiliary treatment of severe craniocerebral injury]

    PubMed ID: 15074087

    Panax notoginseng injection added to usual care improved intracranial pressure, GCS and 3‑month outcomes after severe head injury—direct recovery benefits.

  31. [Clinical observation on shenmai injection in preventing and treating adverse reaction of chemotherapy on advanced non-small cell lung cancer]

    PubMed ID: 16841676

    Shenmai improved QoL, maintained weight and reduced chemo adverse reactions in lung cancer patients—supports recovery/tolerance of therapy.

  32. [Effects of shenmai injection on the clinical efficacy of noninvasive ventilation in patients with severe respiratory failure caused by chronic obstructive pulmonary disease]

    PubMed ID: 16983914

    Shenmai shortened ventilation and hospital stay and improved gas exchange in severe COPD—clinical recovery endpoints improved.

  33. [Effect of Shenfu injection in postoperative recovery after abdominal surgery]

    PubMed ID: 17455472

    Faster return of flatus and improved oxidative/immune markers indicate enhanced postoperative recovery with Shenfu (multi‑component).

  34. [Effect of Panax notoginseng saponins on serum neuronal specific enolase and rehabilitation in patients with cerebral hemorrhage]

    PubMed ID: 17343007

    Panax notoginseng saponins lowered NSE and improved NIHSS/Barthel Index after cerebral hemorrhage, indicating neurologic recovery benefit.

  35. Effect of Shengmai Injection on cardiac function and inflammatory reaction in patients with acute coronary syndrome

    PubMed ID: 18679601

    Shengmai improved cardiac function and lowered inflammation in ACS patients, supporting recovery/functional improvement.

  36. [Effect of yiqi wenyang huoxue recipe on bone marrow stem cells' mobilization and its influence on heart function in patients with myocardial infarction]

    PubMed ID: 19317161

    Multi‑herb treatment including ginseng improved infarct size and LVEF after MI and mobilized progenitor cells—strong recovery signal (multi‑component).

  37. Effects of combined Chinese drugs and chemotherapy in treating advanced non-small cell lung cancer

    PubMed ID: 20082245

    Chinese drug package (includes ginseng) added to chemo increased tumor response and median survival, supporting oncologic recovery/benefit (multi‑component).

  38. [Efficacy of Shenyi Capsule combined with gemcitabine plus cisplatin in treatment of advanced esophageal cancer: a randomized controlled trial]

    PubMed ID: 19912736

    Shenyi capsule plus chemotherapy lowered VEGF, reduced chemo side effects and increased 1‑year survival—supports treatment recovery/reduction in toxicity.

  39. Radix/rhizoma notoginseng extract (sanchitongtshu) for ischemic stroke: a randomized controlled study

    PubMed ID: 21094030

    Panax notoginseng extract added to low‑dose aspirin improved neurological deficit scores and activities of daily living after ischemic stroke (RCT, combination therapy).

  40. The effects of the Kampo medicine (Japanese herbal medicine) "Daikenchuto" on the surgical inflammatory response following laparoscopic colorectal resection

    PubMed ID: 22202972

    Daikenchuto reduced postoperative inflammation and accelerated bowel recovery after laparoscopic colorectal surgery (multi‑herb product including ginseng).

  41. Daikenchuto stimulates colonic motility after laparoscopic-assisted colectomy

    PubMed ID: 24895799

    Daikenchuto (contains ginseng) shortened time to first flatus/bowel movement after colectomy, suggesting faster GI recovery (multi‑herb).

  42. [Effects of acupuncture and "Tongxinluo" capsule on plasma lysophosphatidic acid level in patients with acute cerebral infarction]

    PubMed ID: 25632575

    Acute stroke patients improved more when treated with regimens including Panax notoginseng saponins—supports enhanced recovery in multimodal therapy.

  43. Ginsenoside Rd Is Efficacious Against Acute Ischemic Stroke by Suppressing Microglial Proteasome-Mediated Inflammation

    PubMed ID: 26081140

    Pooled trials: ginsenoside Rd improved disability and neurologic outcomes after acute ischemic stroke—strong recovery support.

  44. Adjuvant effects of fermented red ginseng extract on advanced non-small cell lung cancer patients treated with chemotherapy

    PubMed ID: 26142337

    Fermented red ginseng improved fatigue and reduced chemo toxicities—adjunctive recovery support during chemotherapy.

Blood circulation (41)
  1. Xinyue Capsule in patients with stable coronary artery disease after percutaneous coronary intervention: a multicenter, randomized, placebo-controlled trial

    PubMed ID: 32446979

    Large multicenter RCT: Panax quinquefolius saponins (Xinyue) reduced major cardiac events after PCI (strong cardiovascular/circulatory benefit).

  2. [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]

    PubMed ID: 15143716

    Panax notoginseng saponins (PNS) reduced platelet activation/aggregation and altered vasoactive markers vs aspirin in hyperviscosity patients — direct circulation support evidence.

  3. Improvement of hematoma absorption and neurological function in patients with acute intracerebral hemorrhage treated with Xueshuantong

    PubMed ID: 23062408

    Xueshuantong (contains Panax notoginseng) accelerated hematoma absorption and reduced inflammatory markers after intracerebral hemorrhage — supports vascular/haemostatic effects.

  4. Combination of Panax notoginseng saponins and aspirin potentiates platelet inhibition with alleviated gastric injury via modulating arachidonic acid metabolism

    PubMed ID: 33370633

    PNS added to aspirin increased platelet inhibition and reduced TXB2/COX‑1 oxylipids while improving gastric symptoms — clinically relevant circulatory modulation.

  5. [Effects of Astragalus and saponins of Panax notoginseng on MMP-9 in patients with type 2 diabetic macroangiopathy]

    PubMed ID: 15706857

    Panax notoginseng saponins in diabetic macroangiopathy reduced MMP‑9 (vascular remodeling marker) and improved lipid profile—direct vascular benefit.

  6. Effects of huoxin formula on the arterial functions of patients with coronary heart disease

    PubMed ID: 31199705

    Huoxin multi‑herb adjunct including Panax notoginseng improved IMT progression, decreased CAVI/ABI and lowered inflammatory mediators in CHD patients (clinical arterial function improvements).

  7. Effect of American ginseng (Panax quinquefolius L.) on arterial stiffness in subjects with type-2 diabetes and concomitant hypertension

    PubMed ID: 23973636

    12‑week RCT: 3 g/day American ginseng in people with T2D and hypertension reduced radial augmentation index (−5.3%) and systolic BP (−11.7%) vs placebo—strong clinical vascular effects.

  8. [Clinical study on effect of Shenmai Injection in treating congestive heart failure]

    PubMed ID: 14666758

    Shenmai injection (contains ginseng) improved hemodynamics and heart function in CHF patients (human clinical hemodynamic data).

  9. [Effect of combined therapy of shenmai and compound danshen injection on myocardial reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction]

    PubMed ID: 15250199

    Shenmai plus danshen improved early LV function (Tei index) and reduced oxidative/inflammatory markers after AMI.

  10. The efficacy of Chinese herbal medicines on acute coronary syndrome with renal insufficiency after percutaneous coronary intervention

    PubMed ID: 31689480

    Adjunct Chinese herbal regimen including American ginseng extract reduced cardiac events after PCI—clinical cardiovascular outcome signal (multi‑herb).

  11. Antiedema effects of Siberian ginseng in humans and its molecular mechanism of lymphatic vascular function in vitro

    PubMed ID: 27333960

    Siberian ginseng acutely reduced lower‑limb edema via lymphatic endothelial activation (direct circulation/lymphatic effect).

  12. Vascular effects of combined enriched Korean Red ginseng (Panax Ginseng) and American ginseng (Panax Quinquefolius) administration in individuals with hypertension and type 2 diabetes: A randomized controlled trial

    PubMed ID: 32147072

    Enriched Korean Red + American ginseng produced a small but significant reduction in central systolic blood pressure in hypertensive/diabetic patients.

  13. [Clinical and experimental study of shenshao tongguan pian in treating angina pectoris of coronary heart disease]

    PubMed ID: 2268917

    Large RCT of a TCM containing ginseng reported marked improvements in angina symptoms and ECG (strong clinical circulation signal, multi‑ingredient product).

  14. [Protective effects of ginsenoside on myocardiac ischemic and reperfusion injuries]

    PubMed ID: 7842343

    Adding ginsenosides during cardioplegia associated with better postoperative cardiac function and myocardial ultrastructure.

  15. [Clinical study on xinkening in treating asymptomatic myocardial ischemia in coronary heart disease]

    PubMed ID: 7950196

    Small trial of a ginseng‑containing treatment reduced ECG markers and total time of asymptomatic myocardial ischemia.

  16. [Effects of red ginseng on the congestive heart failure and its mechanism]

    PubMed ID: 7549378

    Red ginseng improved hemodynamic and biochemical markers in severe heart failure (small RCT).

  17. [Comparative study on effect of Panax notoginseng and ticlid in treating early diabetic nephropathy]

    PubMed ID: 11475719

    Panax notoginseng altered thromboxane/PGF1α and reduced urinary albumin in diabetic kidney disease — favorable vascular/thrombotic effects.

  18. [Effect of Panax notoginseng saponins combined isovolumic haemodilution on the retinal microcirculation of patients with retinal vein occlusion]

    PubMed ID: 12206008

    Panax notoginseng plus haemodilution improved retinal circulation time and lesion recovery in retinal vein occlusion — microcirculatory benefit.

  19. [Study on effect of shenmai injection in protecting myocardium against ischemia-reperfusion injury in thrombolytic therapy with urokinase for acute myocardial infarction patients evaluated by 99mTc-MIBI myocardial imaging]

    PubMed ID: 12577392

    Shengmai (multi‑herb) adjunct to thrombolysis reduced ischemic myocardial area and increased EF — improved cardiac perfusion/function reported.

  20. [Effect of shengmai injection on hemodynamics in patients with dilated cardiomyopathy]

    PubMed ID: 12584790

    Shengmai injection added to care in DCM improved EF and stroke volume and lowered vascular resistance — positive hemodynamic effects (multi‑herb context).

  21. [Influence of large amount of shengmai injection on blood coagulation in patients with chronic heart failure]

    PubMed ID: 12764910

    Shengmai injection (contains ginseng) plus usual care reduced P‑selectin, vWF and D‑dimer in chronic heart failure—markers relevant to coagulation/vascular function.

  22. [Effect of Shenfu injection in postoperative recovery after abdominal surgery]

    PubMed ID: 17455472

    Shenfu injection lowered whole blood viscosity and related hemorheology measures postoperatively (multi‑component product).

  23. Effect of Shengmai Injection on cardiac function and inflammatory reaction in patients with acute coronary syndrome

    PubMed ID: 18679601

    Shengmai injection increased EF/CO/stroke volume and lowered hs‑CRP in acute coronary syndrome patients (multi‑herb adjunctive therapy).

  24. Effect of Shengmai injection on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus

    PubMed ID: 19082800

    Shengmai injection produced large improvements in NO/ET‑1/AngII and EF in CHD with diabetes (randomized, multi‑herb product).

  25. [Effect of yiqi wenyang huoxue recipe on bone marrow stem cells' mobilization and its influence on heart function in patients with myocardial infarction]

    PubMed ID: 19317161

    Multi‑herb formula (includes ginseng) increased peripheral CD34+ cells and improved LVEF and infarct size after MI.

  26. Supplementation of cheonggukjang and red ginseng cheonggukjang can improve plasma lipid profile and fasting blood glucose concentration in subjects with impaired fasting glucose

    PubMed ID: 21128827

    Red ginseng–enriched product lowered total and LDL cholesterol, supporting vascular/circulatory risk factor improvement.

  27. Red ginseng extract improves coronary flow reserve and increases absolute numbers of various circulating angiogenic cells in patients with first ST-segment elevation acute myocardial infarction

    PubMed ID: 20641058

    Randomized post‑MI trial showing increased coronary flow reserve and early mobilization of angiogenic cells with red ginseng—robust cardiovascular biologic effects.

  28. Study on improving blood flow with Korean red ginseng substances using digital infrared thermal imaging and Doppler sonography: randomized, double blind, placebo-controlled clinical trial with parallel design

    PubMed ID: 23596810

    Thermal imaging study showed improved peripheral thermal distribution (proxy for circulation) though Doppler unchanged.

  29. Efficacy and safety of Korean red ginseng for cold hypersensitivity in the hands and feet: a randomized, double-blind, placebo-controlled trial

    PubMed ID: 25284751

    8‑week RCT objectively increased hand/foot skin temperatures and improved rewarming and symptoms in cold hypersensitivity (vascular effect).

  30. Combination of autologous transplantation of G-CSF-mobilized peripheral blood mononuclear cells and Panax notoginseng saponins in the treatment of unreconstructable critical limb ischemia

    PubMed ID: 24632316

    Adding Panax notoginseng saponins to cell therapy significantly improved ABI, TcPO2 and walking distance in critical limb ischemia—strong vascular/flow signal.

  31. Clinical study of Butylphthalide combined with Xue Shuan Tong on serum inflammatory factors and prognosis effect of patients with cerebral infarction

    PubMed ID: 26525022

    Xue Shuan Tong reduced carotid intima‑media thickness and inflammatory markers—vascular structural improvements reported.

  32. Ginsenoside Rd Is Efficacious Against Acute Ischemic Stroke by Suppressing Microglial Proteasome-Mediated Inflammation

    PubMed ID: 26081140

    Pooled trials of ginsenoside Rd improved neurologic outcomes after ischemic stroke—supports cerebrovascular therapeutic effect.

  33. A randomized, double-blind, multicenter, placebo-controlled clinical study on the efficacy and safety of Shenmai injection in patients with chronic heart failure

    PubMed ID: 27045864

    Shenmai injection improved functional class and 6MWD in chronic heart failure patients—supportive of circulatory/functional benefit (short term).

  34. Blood pressure-lowering effect of Korean red ginseng associated with decreased circulating Lp-PLA2 activity and lysophosphatidylcholines and increased dihydrobiopterin level in prehypertensive subjects

    PubMed ID: 26843120

    Korean red ginseng lowered systolic and diastolic BP and favorably changed vascular/inflammatory metabolites in prehypertensive adults—robust BP/circulation evidence.

  35. [Effect of Shenmai Injection on Vascular Endothelial Dependence Diastolic Function in Coronary Heart Disease Patients]

    PubMed ID: 30650479

    Shenmai (contains ginseng) improved endothelial‑dependent vasodilation, increased NO, and lowered vasoconstrictor markers—strong circulation signal (multi‑component).

  36. Effects of Shenmai injection on the values of CO, SV, and EF in patients undergoing off-pump coronary artery bypass graft: A randomized, clinical trial

    PubMed ID: 29517675

    Shenmai infusion produced intraoperative increases in cardiac output, stroke volume and EF in CABG patients—hemodynamic/circulatory improvement.

  37. Effect of Korean Red Ginseng on Cholesterol Metabolites in Postmenopausal Women with Hypercholesterolemia: A Pilot Randomized Controlled Trial

    PubMed ID: 33171597

    KRG modestly lowered cholesterol metabolites and produced a small DBP decrease in postmenopausal women (favorable vascular risk marker changes).

  38. Protective effects of Panax ginseng against doxorubicin-induced cardiac toxicity in patients with non-metastatic breast cancer: A randomized, double-blind, placebo-controlled clinical trial

    PubMed ID: 35975564

    Small RCT: Panax ginseng adjunct during anthracycline chemo preserved LVEF and reduced cardiotoxicity incidence (direct cardioprotective/circulatory support).

  39. The effect of Tianjiang Xueshuantong Wan pills on ischemia-reperfusion injury after thrombolysis in acute cerebral infarction

    PubMed ID: 35246395

    After thrombolysis, Panax‑containing therapy reduced reperfusion‑inflammation markers and improved neurologic deficits (supports vascular/reperfusion protection).

  40. Efficacy and Safety of Panax notoginseng Saponins in the Treatment of Adults With Ischemic Stroke in China: A Randomized Clinical Trial

    PubMed ID: 37338907

    Large trial: Panax notoginseng saponins increased functional independence after ischemic stroke—benefit in cerebrovascular recovery/circulation.

  41. Efficacy of Xueshuantong Injection in Reducing Residual Inflammatory Risk in Unstable Angina Patients: A Randomized Double-Blind Controlled Trial

    PubMed ID: 41111082

    Xueshuantong reduced CRP/IL-6 and other markers in unstable angina, suggesting cardiovascular/circulatory benefit.

Immune support (27)
  1. [Effect of cellular immune supportive treatment on immunity of esophageal carcinoma patients after modern two-field lymph node dissection]

    PubMed ID: 17626759

    Perioperative Shenqi injection (contains ginseng) improved early postoperative T‑cell subsets (CD3+CD4+, CD4+/CD8+).

  2. [Effects of Hengyan medicinal recipe on the regulation of immunity in patients with severe sepsis: a prospective clinical trial]

    PubMed ID: 21315002

    Multi‑herb recipe including red ginseng reduced IL‑6 and TNF‑α and increased CD4+ T cells in severe sepsis patients (clinical immune marker improvements).

  3. Effects of a new nutraceutical ingredient on allergen-induced sulphidoleukotrienes production and CD63 expression in allergic subjects

    PubMed ID: 18817894

    Mixed‑plant nutraceutical containing Panax reduced leukotriene production (−43%) and basophil activation (CD63 −64.8%) in allergic subjects (large biomarker changes).

  4. [Effect of Tangyikang in improving the function of pancreatic islet beta cells in patients with latent autoimmune diabetes mellitus in adults]

    PubMed ID: 19123322

    Herbal decoction including red ginseng altered cytokines (↑IL‑4, ↓IFN‑γ) and improved beta‑cell autoimmunity markers in LADA patients.

  5. Treatment of 37 patients with refractory idiopathic thrombocytopenic purpura by shengxueling

    PubMed ID: 17578315

    Ginseng‑saponin preparation increased clinical response in refractory ITP (immune/hematologic effect).

  6. Immunomodulatory effects of two extracts of Panax ginseng C.A. Meyer

    PubMed ID: 2100737

    8‑week RCT showing increases in PMN chemotaxis, phagocytosis and intracellular killing with ginseng extract.

  7. [Effects of Shenmai injection on immune function in stomach cancer patients after chemotherapy]

    PubMed ID: 8580688

    Shenmai (contains ginseng) improved T cell counts and NK/LAK activity after chemotherapy.

  8. Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold [corrected]

    PubMed ID: 8879982

    Large RCT: G115 increased vaccine antibody titres, NK activity and markedly reduced respiratory infections — strong immune support.

  9. [Clinical observation on nasopharyngeal carcinoma treated with combined therapy of radiotherapy and ginseng polysaccharide injection]

    PubMed ID: 12577414

    Ginseng polysaccharide injection raised NK/LAK activity and modestly improved remission in NPC — supports immune stimulation (in combined therapy setting).

  10. A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults

    PubMed ID: 14687309

    CVT-E002 (North American ginseng extract) substantially reduced laboratory‑confirmed influenza/RSV and symptom burden in institutionalized elderly.

  11. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial

    PubMed ID: 16247099

    North American ginseng extract reduced number, severity and duration of common colds in adults over a 4‑month season.

  12. [Influence of Shenmai injection on blood serum tumor necrosis factor and bone marrow CD34+ cell's apoptosis of chronic aplastic anemia patient]

    PubMed ID: 16245914

    Shenmai (ginseng-containing) plus standard therapy lowered TNF‑α and improved clinical response in aplastic anemia—immunomodulatory marker changes.

  13. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial

    PubMed ID: 16566675

    COLD-fX (North American ginseng extract) reduced incidence and duration of acute respiratory illnesses in seniors—clinical immune benefit.

  14. [Effect of Shenfu injection in postoperative recovery after abdominal surgery]

    PubMed ID: 17455472

    Shenfu increased IgG/IgA postoperatively, suggesting some immune modulation (multi-component).

  15. [Clinical study on effect of total panax notoginseng saponins on immune related inner environment imbalance in rheumatoid arthritis patients]

    PubMed ID: 17717913

    Panax notoginseng saponins reduced CRP and other inflammatory indices in RA, indicating anti‑inflammatory/immune effects.

  16. [Impact of shengmal injection on changes of immunological function in patients after cardiopulmonary bypass]

    PubMed ID: 19526756

    Shengmai altered perioperative WBC, neutrophils and cytokines consistent with immune modulation (multi‑component product).

  17. Preventive effect of Korean red ginseng for acute respiratory illness: a randomized and double-blind clinical trial

    PubMed ID: 23255845

    Large RCT showed a significant reduction in acute respiratory illness incidence with KRG.

  18. A randomized, controlled trial of Panax quinquefolius extract (CVT-E002) to reduce respiratory infection in patients with chronic lymphocytic leukemia

    PubMed ID: 22266154

    In CLL patients, American ginseng increased antibody seroconversion to respiratory viruses despite no clinical ARI reduction.

  19. A 14-week randomized, placebo-controlled, double-blind clinical trial to evaluate the efficacy and safety of ginseng polysaccharide (Y-75)

    PubMed ID: 25297058

    14‑week RCT in older adults showed large increases in NK activity, phagocytosis and TNF‑α with a ginseng polysaccharide.

  20. Effect of ginseng polysaccharides and dendritic cells on the balance of Th1/Th2 T helper cells in patients with non-small cell lung cancer

    PubMed ID: 25618966

    Adding ginseng polysaccharides to dendritic‑cell therapy shifted cytokines toward Th1 (immune biomarker effects; combined therapy).

  21. Impact of extended ginsenoside Rb1 on early chronic kidney disease: a randomized, placebo-controlled study

    PubMed ID: 27853891

    Ginsenoside Rb1 reduced inflammation and oxidative stress in early CKD patients—clinically relevant immune/inflammatory benefit.

  22. The Effect of Korean Red Ginseng on Symptoms and Inflammation in Patients With Allergic Rhinitis

    PubMed ID: 32070136

    KRG lowered Th2 biomarkers (IL‑4, nasal eosinophils, IgE) and improved allergic symptoms—direct immunomodulatory effects in allergy.

  23. Efficacy of the Panax Notoginseng Ejiao Suppository in the Treatment of Patients with Ulcerative Proctitis and Its Effect on Inflammatory Response and Immune Function

    PubMed ID: 36188425

    Ulcerative proctitis trial showed improved Th17/Treg balance and reduced inflammatory cytokines with Panax notoginseng formulation (immune modulation).

  24. The effect of Tianjiang Xueshuantong Wan pills on ischemia-reperfusion injury after thrombolysis in acute cerebral infarction

    PubMed ID: 35246395

    Post‑thrombolysis formula reduced IL‑6 and TNF and other reperfusion/inflammatory markers (immuno‑inflammatory benefit with Panax-containing product).

  25. Effect of Baihe Gujin decoction combined with Shengmai powder on the expression of IL-1β and IL-1Ra in peripheral blood CD14+ monocytes from patients with pulmonary tuberculosis

    PubMed ID: 35869725

    Herbal adjunct lowered IL‑1β/IL‑1Ra gene expression in monocytes in TB patients (reduced proinflammatory gene expression; contains Shengmai/Shengmai-related herbs including Panax).

  26. Korean Red Ginseng Potentially Improves Maintaining Antibodies after COVID-19 Vaccination: A 24-Week Longitudinal Study

    PubMed ID: 37049424

    Korean red ginseng users had a sustained vaccine antibody response over 24 weeks (large cohort; nonrandomized).

  27. Efficacy of Xueshuantong Injection in Reducing Residual Inflammatory Risk in Unstable Angina Patients: A Randomized Double-Blind Controlled Trial

    PubMed ID: 41111082

    Xueshuantong injection reduced inflammatory markers (CRP, IL‑6) in unstable angina, consistent with immune/inflammatory modulation.

Energy & Fatigue (17)
  1. Ginseng Berry Concentrate Alleviates Fatigue in Humans: A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial

    PubMed ID: 41022533

    Ginseng berry concentrate reduced subjective fatigue scores and resting lactic acid versus placebo in fatigued adults.

  2. Safety and efficacy of Ninjin'yoeito along with iron supplementation therapy for preoperative anemia, fatigue, and anxiety in patients with gynecological disease: an open-label, single-center, randomized phase-II trial

    PubMed ID: 35701778

    Ninjin'yoeito (contains ginseng) plus iron produced greater fatigue reductions than iron alone in preoperative anemia patients (direct clinical fatigue improvement).

  3. The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study

    PubMed ID: 34578969

    8‑week RCT in postmenopausal women: KRG reduced fatigue severity (FSS) and increased mitochondrial DNA (plausible mechanism), direct evidence of fatigue reduction.

  4. Korean red ginseng for cancer-related fatigue in colorectal cancer patients with chemotherapy: A randomised phase III trial

    PubMed ID: 32172198

    Large phase III RCT: KRG taken during chemotherapy reduced cancer‑related fatigue and improved fatigue-related QoL measures (direct clinical fatigue benefit).

  5. Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA

    PubMed ID: 19415341

    Large randomized dose‑finding trial showed dose‑dependent trends (especially high doses) toward reduced cancer‑related fatigue and improved patient‑reported benefit.

  6. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity

    PubMed ID: 15982990

    Acute Panax ginseng reduced subjective mental fatigue during sustained mental effort.

  7. Ginseng improves pulmonary functions and exercise capacity in patients with COPD

    PubMed ID: 12814035

    COPD patients had increased VO2max and exercise capacity after 3 months of G115 — consistent with increased functional energy.

  8. Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial

    PubMed ID: 23613825

    RDB trial in idiopathic chronic fatigue: Panax ginseng reduced mental fatigue scores and lowered oxidative‑stress markers — strong direct evidence.

  9. Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial

    PubMed ID: 28753932

    Red ginseng improved fatigue subscale of HRQL in chemotherapy survivors vs placebo — supports reduced fatigue in a clinical population.

  10. A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action

    PubMed ID: 34396468

    American ginseng produced acute and short‑term reductions in mental fatigue and improved self‑assurance in healthy adults.

  11. Xinyue Capsule in patients with stable coronary artery disease after percutaneous coronary intervention: a multicenter, randomized, placebo-controlled trial

    PubMed ID: 32446979

    Xinyue (Panax quinquefolius saponins) after PCI improved SF‑36 vitality scores at 12 months (patient‑reported energy/vitality improvement).

  12. A Phase II Randomized Controlled Trial of Renshen Yangrong Tang Herbal Extract Granules for Fatigue Reduction in Cancer Survivors

    PubMed ID: 31668965

    Multi‑herb formula that included ginseng produced clinically meaningful reductions in cancer‑related fatigue (ginseng may contribute but product not ginseng‑only).

  13. Anti-Fatigue Effects of Enzyme-Modified Ginseng Extract: A Randomized, Double-Blind, Placebo-Controlled Trial

    PubMed ID: 27754709

    Enzyme‑modified ginseng significantly reduced visual-analogue fatigue scores after 4 weeks in healthy adults.

  14. Adjuvant effects of fermented red ginseng extract on advanced non-small cell lung cancer patients treated with chemotherapy

    PubMed ID: 26142337

    Fermented red ginseng improved fatigue scores in lung cancer patients receiving chemotherapy—clinical fatigue benefit as adjunctive therapy.

  15. Effects of ginseng on peripheral blood mitochondrial DNA copy number and hormones in men with metabolic syndrome: A randomized clinical and pilot study

    PubMed ID: 26860800

    Red ginseng increased leukocyte mtDNA copy number and anabolic hormones—biomarkers consistent with increased cellular energy.

  16. Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2

    PubMed ID: 23853057

    Large phase III RCT showed statistically and clinically significant reduction in cancer‑related fatigue by 8 weeks.

  17. Ginseng in the treatment of fatigue in multiple sclerosis: a randomized, placebo-controlled, double-blind pilot study

    PubMed ID: 23301896

    3‑month RCT in MS showed significant reductions in fatigue (MFIS) and improved QoL.

Mental clarity (21)
  1. Effect of Hydroponically Grown Red Panax Ginseng on Perceived Stress Level, Emotional Processing, and Cognitive Functions in Moderately Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study

    PubMed ID: 40289951

    Hydroponic red ginseng reduced stress and produced modest improvements on cognitive task measures in stressed adults.

  2. A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action

    PubMed ID: 34396468

    RDB trial of American ginseng showed robust improvements in attention accuracy, reaction time and reduced mental fatigue — strong direct evidence.

  3. Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial

    PubMed ID: 23613825

    In chronic fatigue, ginseng reduced mental fatigue and oxidative stress — may enhance mental clarity via reduced cognitive fatigue.

  4. [Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment]

    PubMed ID: 17993008

    Traditional herbal capsule including ginseng improved memory scores in MCI patients vs baseline — supports cognitive benefit (multi‑component).

  5. A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans

    PubMed ID: 32731478

    Multi‑ingredient beverage including ginseng acutely increased frontal O2 and improved some mood/fatigue measures — supports acute cognitive clarity.

  6. Effects of Korean red ginseng extract on behavior in children with symptoms of inattention and hyperactivity/impulsivity: a double-blind randomized placebo-controlled trial

    PubMed ID: 25369174

    Korean red ginseng modestly improved attention/hyperactivity scores and QEEG in children with ADHD symptoms.

  7. The cognitive, subjective, and physical effects of a ginkgo biloba/panax ginseng combination in healthy volunteers with neurasthenic complaints

    PubMed ID: 9493479

    90‑day Ginkgo/ ginseng combo produced dose‑related memory improvements in middle‑aged adults.

  8. The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers

    PubMed ID: 11140327

    Large RCT of Ginkgo/ginseng combo improved composite memory quality by ~7.5%.

  9. Effect of Memo®, a natural formula combination, on Mini-Mental State Examination scores in patients with mild cognitive impairment

    PubMed ID: 23950642

    4‑week triple‑natural formula (includes ginseng) increased MMSE by ~2 points in MCI.

  10. [A follow-up study on a randomized, single-blind control of King's Brain pills in treatment of memory disorder in elderly people with MCI in a Beijing community]

    PubMed ID: 15620194

    Compound ginseng product improved multiple memory test scores in elderly with mild cognitive impairment (but was multi‑herbal and single‑blind).

  11. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity

    PubMed ID: 15982990

    Single doses of Panax ginseng improved sustained-attention task performance (Serial Sevens) and reduced mental fatigue acutely.

  12. Panax ginseng enhances cognitive performance in Alzheimer disease

    PubMed ID: 18580589

    Panax ginseng associated with short‑term cognitive improvements in Alzheimer's patients (open‑label adjunctive study).

  13. An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer's disease

    PubMed ID: 18684311

    High‑dose Korean red ginseng plus dementia meds improved ADAS and CDR scores over 12 weeks (open‑label adjunct).

  14. Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study

    PubMed ID: 20676609

    Standardized American ginseng produced acute, dose‑dependent improvements in memory and working memory in healthy adults.

  15. Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults

    PubMed ID: 20737519

    Acute single and 7‑day dosing produced modest improvements in calmness and some working‑memory/mental arithmetic in healthy young adults.

  16. HT1001, a proprietary North American ginseng extract, improves working memory in schizophrenia: a double-blind, placebo-controlled study

    PubMed ID: 22213250

    Standardized North American ginseng (HT1001) improved visual working memory in people with schizophrenia (4‑week RCT).

  17. Heat-processed ginseng enhances the cognitive function in patients with moderately severe Alzheimer's disease

    PubMed ID: 22780999

    Small RCT reported cognitive improvements (MMSE/ADAS) with heat‑processed ginseng in Alzheimer's patients.

  18. Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle-age adults

    PubMed ID: 25778987

    Single 200 mg American ginseng acutely improved working memory in middle-aged adults—direct human evidence for mental clarity.

  19. Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial

    PubMed ID: 30309327

    Shenmai injection (contains ginseng) was associated with better short‑term postoperative cognitive scores and lower neuronal injury biomarkers after cardiac surgery.

  20. Effects of Korean red ginseng on human gray matter volume and cognitive function: A voxel-based morphometry study

    PubMed ID: 33217050

    Eight‑week RCT showed increased parahippocampal GMV and modest cognitive score improvement with KRG in healthy adults (direct brain/memory structural & functional change).

  21. Efficacy and Safety of Panax ginseng Sprout Extract in Subjective Memory Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

    PubMed ID: 38931306

    Panax ginseng sprout extract improved verbal/visual memory and MoCA scores versus placebo in adults with memory complaints.

Healthy aging (17)
  1. A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults

    PubMed ID: 14687309

    CVT-E002 reduced influenza/RSV in institutionalized elderly—supports health protection in aging populations.

  2. The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study

    PubMed ID: 34578969

    Increases in mtDNA and antioxidant status with reduced fatigue in postmenopausal women support cellular healthy‑aging mechanisms.

  3. Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

    PubMed ID: 34684351

    12‑week ginseng extract increased bone‑formation markers in postmenopausal women with osteopenia (supports musculoskeletal healthy aging).

  4. Effect of Shengmai injection on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus

    PubMed ID: 19082800

    Shengmai injection markedly improved endothelial markers and EF in CHD with diabetes; endothelial health links to healthy aging (multi‑herb).

  5. Effects of ginseng on peripheral blood mitochondrial DNA copy number and hormones in men with metabolic syndrome: A randomized clinical and pilot study

    PubMed ID: 26860800

    Improvements in mitochondrial proxy, testosterone and IGF‑1 in metabolic‑syndrome men are biomarkers relevant to healthy aging.

  6. Impact of extended ginsenoside Rb1 on early chronic kidney disease: a randomized, placebo-controlled study

    PubMed ID: 27853891

    Rb1 improved renal function and reduced oxidative stress/inflammation in early CKD—organ-level benefit relevant to aging.

  7. Xinyue Capsule in patients with stable coronary artery disease after percutaneous coronary intervention: a multicenter, randomized, placebo-controlled trial

    PubMed ID: 32446979

    Large CV outcomes trial (reduced cardiac events) with Panax quinquefolius saponins supports long‑term cardiovascular health, a component of healthy aging.

  8. [A follow-up study on a randomized, single-blind control of King's Brain pills in treatment of memory disorder in elderly people with MCI in a Beijing community]

    PubMed ID: 15620194

    Memory improvements in elderly with MCI indicate potential healthy aging cognitive support, though study was multi‑herbal.

  9. Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial

    PubMed ID: 28753932

    Red ginseng lowered genotoxicity marker (micronucleus yield) and improved multiple HRQL domains — suggests cellular‑protective/aging relevance.

  10. Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial

    PubMed ID: 23613825

    Antioxidant marker improvements in chronic fatigue patients could support long‑term cellular health.

  11. Improvement of symptoms of aging in males by a preparation LEOPIN ROYAL containing aged garlic extract and other five of natural medicines - comparison with traditional herbal medicines (Kampo)

    PubMed ID: 24844765

    Multi‑ingredient product including ginseng improved Aging Males' Symptoms and erectile scores over 6 months (clinical aging‑related endpoints).

  12. The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers

    PubMed ID: 11140327

    Ginkgo/ginseng combo produced sustained composite memory improvement in middle‑aged adults—relevant to cognitive aging.

  13. The effect of Korean Red Ginseng on sarcopenia biomarkers in type 2 diabetes patients

    PubMed ID: 32470863

    24‑week KRG trial improved sarcopenia‑related biomarkers (follistatin, SHBG), relevant to age‑related muscle decline and healthy aging.

  14. Effect of Memo®, a natural formula combination, on Mini-Mental State Examination scores in patients with mild cognitive impairment

    PubMed ID: 23950642

    Memo (includes ginseng) increased MMSE in MCI patients over 4 weeks, suggesting short‑term cognitive benefit in aging.

  15. Influence of a double blind pharmacological trial on two domains of well-being in subjects with age associated memory impairment

    PubMed ID: 15374200

    9‑month ginseng‑containing vitamin complex improved memory index and life satisfaction in older adults.

  16. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial

    PubMed ID: 16566675

    COLD-fX reduced incidence and duration of ARI in community-dwelling seniors—clinical protective effect for older adults.

  17. Panax ginseng enhances cognitive performance in Alzheimer disease

    PubMed ID: 18580589

    Cognitive improvements in Alzheimer's patients suggest potential support for age‑related cognitive decline (adjunctive open‑label evidence).

Sexual wellness (17)
  1. The enhancement of female sexual function with ArginMax, a nutritional supplement, among women differing in menopausal status

    PubMed ID: 16959660

    Larger randomized trial of ArginMax (contains ginseng) showed significant improvements in sexual desire and overall satisfaction in women — strong clinical support for sexual function (multi‑ingredient).

  2. Improvement of symptoms of aging in males by a preparation LEOPIN ROYAL containing aged garlic extract and other five of natural medicines - comparison with traditional herbal medicines (Kampo)

    PubMed ID: 24844765

    LER multi‑ingredient product (includes ginseng) improved Aging Males' Symptoms and IIEF‑5 erectile scores versus Kampo control (clinical improvement; multi‑herb).

  3. Clinical efficacy of Korean red ginseng for erectile dysfunction

    PubMed ID: 8750052

    Korean red ginseng produced greater partial improvements in erectile function, rigidity, girth and libido versus placebo (RCT).

  4. A double-blind crossover study evaluating the efficacy of korean red ginseng in patients with erectile dysfunction: a preliminary report

    PubMed ID: 12394711

    Korean red ginseng significantly improved IIEF scores and penile rigidity vs placebo in men with ED — good clinical evidence for sexual vitality.

  5. Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction

    PubMed ID: 16855773

    Korean red ginseng produced clinically meaningful increases in IIEF‑5 and a majority reported improved erections in men with mild‑moderate ED.

  6. Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction

    PubMed ID: 19234482

    Tissue‑cultured mountain ginseng extract improved IIEF erectile function and satisfaction vs placebo in an 8‑week RCT.

  7. Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study

    PubMed ID: 20141583

    Korean red ginseng modestly improved sexual arousal scores in menopausal women in a small placebo‑controlled crossover trial.

  8. Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study

    PubMed ID: 23254461

    Multicenter RCT of ginseng berry extract showed modest but statistically significant improvements in erectile and sexual function scores.

  9. Effects of ginseng on peripheral blood mitochondrial DNA copy number and hormones in men with metabolic syndrome: A randomized clinical and pilot study

    PubMed ID: 26860800

    Red ginseng increased total testosterone and IGF‑1 in men with metabolic syndrome—hormonal improvements relevant to sexual vitality.

  10. Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study

    PubMed ID: 25967606

    Korean red ginseng improved sperm concentration, motility and morphology in infertile men in a randomized, double‑blind trial—strong sexual‑health signal.

  11. The effect of ginseng on sexual dysfunction in menopausal women: A double-blind, randomized, controlled trial

    PubMed ID: 31331583

    Double‑blind RCT: Panax ginseng significantly improved female sexual function (FSFI) and menopause‑related QoL in postmenopausal women—strong direct evidence.

  12. The Effect of Panax ginseng on Genitourinary Syndrome in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

    PubMed ID: 33730722

    Four‑week Panax ginseng RCT improved women's self‑reported vaginal atrophy symptoms (subjective sexual/mucosal vitality improvement).

  13. Ginseng treatment improves the sexual side effects of methadone maintenance treatment

    PubMed ID: 31082749

    Ginseng extract improved self‑reported sexual function in methadone‑maintained patients in an RCT—positive short‑term evidence.

  14. A new original nutraceutical formulation ameliorates the effect of Tadalafil on clinical score and cGMP accumulation

    PubMed ID: 34286560

    Panax ginseng‑containing supplement added to tadalafil produced greater erectile function improvement and increased platelet cGMP (direct sexual function benefit).

  15. [Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia]

    PubMed ID: 20940690

    Multi‑ingredient supplement containing ginseng improved sperm motility and sexual satisfaction vs untreated controls — supports male sexual/reproductive outcomes (combination product).

  16. Semen quality in patients with Chlamydia trachomatis genital infection treated concurrently with prulifloxacin and a phytotherapeutic agent

    PubMed ID: 21979301

    Multi‑herbal adjunct (including ginseng) given to men with chronic prostatitis improved sperm concentration and motility — clinically meaningful reproductive improvements.

  17. A double-blind placebo-controlled study of ArginMax, a nutritional supplement for enhancement of female sexual function

    PubMed ID: 11554217

    ArginMax (includes ginseng) improved multiple measures of female sexual function vs placebo in an RCT — supports sexual vitality (attributable to combination product).

Respiratory comfort (16)
  1. [Effects of sheng mai injection on thoracoabdominal motion]

    PubMed ID: 8334346

    Sheng Mai injection (contains ginseng) rapidly normalized thoracoabdominal motion in COPD patients (high responder rate).

  2. Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold [corrected]

    PubMed ID: 8879982

    G115 markedly reduced winter respiratory infections and symptoms vs placebo — clinically meaningful respiratory protection.

  3. [Effect of shenmai injection on diaphragmatic fatigue in children with respiratory failure]

    PubMed ID: 12585186

    Shengmai injection produced rapid clinical improvement, diaphragmatic fatigue relief and better gas exchange in children with respiratory failure — strong effect in acute setting.

  4. [Effects of Yiqi Huoxue Jiedu formula on the gut microbiota in elderly patients with pulmonary-derived sepsis based on 16S rDNA sequencing: a multicenter prospective randomized double-blind controlled trial]

    PubMed ID: 40819941

    YHJF (includes Panax ginseng) improved clinical indices in pulmonary-derived sepsis and altered gut–lung associated microbiota (multi‑herb trial).

  5. Correction of hypoxic effects on target organs in pneumonia with phytotherapy

    PubMed ID: 39681530

    Ginseng-containing phytopreparation improved some hypoxia-related respiratory parameters and oxygen saturation in pneumonia patients.

  6. Effects of Shengmai Yin on pulmonary and cardiac function in coronavirus disease 2019 convalescent patients with cardiopulmonary symptoms: a randomized, double blind, multicenter control trial

    PubMed ID: 36640005

    Shengmai Yin modestly improved chest‑distress in COVID‑19 convalescent patients (direct respiratory symptom relief).

  7. The Effect of Korean Red Ginseng on Symptoms and Inflammation in Patients With Allergic Rhinitis

    PubMed ID: 32070136

    KRG improved allergic rhinorrhea, nasal/eye itching and reduced nasal eosinophils/IL‑4 in allergic rhinitis—direct symptomatic respiratory benefit in upper airway allergy.

  8. Effect of two administration routes of Shenmai Injection () on pulmonary gas exchange function after tourniquet-induced ischemia-reperfusion

    PubMed ID: 27299461

    IV Shenmai preserved pulmonary gas exchange and lowered inflammatory markers after limb ischemia‑reperfusion—clinical respiratory-protective signal.

  9. Preventive effect of Korean red ginseng for acute respiratory illness: a randomized and double-blind clinical trial

    PubMed ID: 23255845

    KRG reduced incidence of acute respiratory illness (clinical respiratory benefit).

  10. [Effect and significance of Shenmai injection on value of vascular endothelial active factors of heart valve replacement patients]

    PubMed ID: 19685757

    Shenmai injection attenuated post‑CPB rises in ET‑1 and improved P(A‑a)DO2/RI, indicating respiratory benefit (multi‑component).

  11. [Protective effect of Shenmai injection on lung injury induced by cardiac pulmonary bypass]

    PubMed ID: 19673331

    Perioperative Shenmai infusion (contains ginseng) reduced lung injury markers and improved oxygenation after CPB (small RCT, multi‑component).

  12. Ginseng improves pulmonary functions and exercise capacity in patients with COPD

    PubMed ID: 12814035

    Randomized trial in moderate–severe COPD showed large, consistent improvements in FEV1, VO2max and exercise capacity — strong respiratory benefit.

  13. Effects of a new nutraceutical ingredient on allergen-induced sulphidoleukotrienes production and CD63 expression in allergic subjects

    PubMed ID: 18817894

    Mixed‑plant product containing Panax reduced leukotriene production and basophil activation (CD63) in allergic subjects—biomarkers relevant to respiratory allergy/inflammation.

  14. [Effects of shenmai injection on the clinical efficacy of noninvasive ventilation in patients with severe respiratory failure caused by chronic obstructive pulmonary disease]

    PubMed ID: 16983914

    Shenmai injection added to NPPV in severe COPD shortened ventilation and hospitalization times and improved arterial blood gases and dyspnea scores.

  15. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial

    PubMed ID: 16566675

    COLD-fX reduced ARI incidence and shortened symptom duration in seniors—clinical respiratory benefit.

  16. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial

    PubMed ID: 16247099

    North American ginseng extract reduced common cold incidence/severity/duration—supports respiratory symptom reduction.

Digestive support (13)
  1. Effect of Daikenchuto, a Traditional Japanese Herbal Medicine, after Total Gastrectomy for Gastric Cancer: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase II Trial

    PubMed ID: 26141466

    Large RCT: DKT modestly sped bowel recovery after gastrectomy, especially in adherent patients—clinical digestive support.

  2. Daikenchuto stimulates colonic motility after laparoscopic-assisted colectomy

    PubMed ID: 24895799

    Daikenchuto (includes ginseng) shortened time to flatus/bowel movement after colectomy (clinically meaningful but multi‑herb).

  3. The effects of the Kampo medicine (Japanese herbal medicine) "Daikenchuto" on the surgical inflammatory response following laparoscopic colorectal resection

    PubMed ID: 22202972

    Daikenchuto (multi‑herb including ginseng) shortened time to first flatus and lowered postoperative CRP after colorectal surgery.

  4. [Effect of Shenfu injection in postoperative recovery after abdominal surgery]

    PubMed ID: 17455472

    Shenfu injection shortened time to first flatus after abdominal surgery, a direct digestive/recovery benefit.

  5. Effect of daikenchuto (TU-100) on gastrointestinal and colonic transit in humans

    PubMed ID: 20378829

    TU‑100 (contains ginseng) accelerated ascending colon emptying in healthy humans at higher dose.

  6. The beneficial effects of Kampo medicine Dai-ken-chu-to after hepatic resection: a prospective randomized control study

    PubMed ID: 23435143

    Dai‑kenchu‑to (Kampo mix that can include ginseng) shortened time to first flatus/bowel movement and reduced postoperative inflammation after liver resection.

  7. Combination of Panax notoginseng saponins and aspirin potentiates platelet inhibition with alleviated gastric injury via modulating arachidonic acid metabolism

    PubMed ID: 33370633

    PNS + aspirin reduced aspirin‑related gastric symptoms (improved SODA dyspepsia scores) — direct improvement in digestive comfort.

  8. Evaluation of TU-100 (Daikenchuto), a Traditional Japanese Kampo Medicine, as an Adjunct to Enhanced Recovery After Surgery, for Acceleration of Gastrointestinal Recovery After Bowel Resection: Results of a Proof-of-Concept, Phase 2, Randomized, Double-Blinded, Placebo-Controlled Trial

    PubMed ID: 41114550

    TU-100 (contains ginseng) modestly accelerated GI recovery, reduced LOS and nausea in post‑resection patients.

  9. Effect of herbal medicine daikenchuto on oral and enteral caloric intake after liver transplantation: A multicenter, randomized controlled trial

    PubMed ID: 29747091

    Daikenchuto after liver transplant accelerated oral/enteral intake and increased portal flow (secondary digestive/recovery signals).

  10. Effects of daikenchuto, a Japanese herb, on intestinal motility after total gastrectomy: a prospective randomized trial

    PubMed ID: 25564322

    Daikenchuto (contains ginseng) after gastrectomy increased stool frequency/form and reduced abdominal gas—clear digestive benefit (multi-herb product).

  11. Efficacy of the Panax Notoginseng Ejiao Suppository in the Treatment of Patients with Ulcerative Proctitis and Its Effect on Inflammatory Response and Immune Function

    PubMed ID: 36188425

    Panax notoginseng–Ejiao suppository improved symptoms and reduced recurrence in ulcerative proctitis (direct GI symptom/inflammation improvement).

  12. Effects of Daikenchuto on postoperative gastrointestinal motility in colorectal carcinoma patients with abdominal pain and distension: a prospective, randomized trial

    PubMed ID: 32588153

    Perioperative Daikenchuto (multi‑herb including ginseng) reduced bowel movements and incomplete evacuation after colorectal surgery (direct digestive symptom benefit).

  13. Responder Analysis of Daikenchuto Treatment for Constipation in Poststroke Patients: A Subanalysis of a Randomized Control Trial

    PubMed ID: 31823650

    Daikenchuto (contains ginseng) produced large, significant improvements in constipation scores and reduced intestinal gas after stroke.

Antioxidant (13)
  1. Effects of shenmai injection on blood SOD activity and MDA level in senile patients with coronary heart disease

    PubMed ID: 15889524

    Shenmai (contains ginseng) increased SOD activity and decreased MDA in elderly coronary heart disease patients—direct antioxidant marker changes.

  2. [Effect of combined therapy of shenmai and compound danshen injection on myocardial reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction]

    PubMed ID: 15250199

    Shenmai (contains ginseng) preserved SOD and lowered MDA after PCI (human clinical data).

  3. Impact of extended ginsenoside Rb1 on early chronic kidney disease: a randomized, placebo-controlled study

    PubMed ID: 27853891

    Extended Rb1 treatment reduced oxidative stress markers in early CKD patients—clinical antioxidant signal.

  4. [Effect of Shenmai Injection on Vascular Endothelial Dependence Diastolic Function in Coronary Heart Disease Patients]

    PubMed ID: 30650479

    Shenmai (contains ginseng) increased SOD and improved NO/oxidative marker profile—supports antioxidant action (multi‑component product).

  5. Cardioprotection of Shenfu Injection against myocardial ischemia/reperfusion injury in open heart surgery

    PubMed ID: 18568324

    Shenfu regimen decreased MDA and increased SOD in small perioperative group (multi‑component injection).

  6. Antioxidant effects of Panax ginseng C.A. Meyer in healthy subjects: a randomized, placebo-controlled clinical trial

    PubMed ID: 21699953

    Placebo-controlled trial in healthy volunteers showing decreased ROS/MDA and increased glutathione and GSH‑Rd with 2 g/day Panax ginseng.

  7. Beneficial effects of Korean red ginseng on lymphocyte DNA damage, antioxidant enzyme activity, and LDL oxidation in healthy participants: a randomized, double-blind, placebo-controlled trial

    PubMed ID: 22805313

    Large RCT showed increased SOD/GPx/catalase and reduced oxidized LDL and DNA oxidative damage.

  8. Antioxidative effects of Korean red ginseng in postmenopausal women: a double-blind randomized controlled trial

    PubMed ID: 24814037

    12‑week RCT increased SOD activity in postmenopausal women (biomarker signal).

  9. The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study

    PubMed ID: 34578969

    Twelve-week RCT showed increased total antioxidant status (TAS) and mtDNA in KRG users (direct antioxidant biomarker change).

  10. The effect of Tianjiang Xueshuantong Wan pills on ischemia-reperfusion injury after thrombolysis in acute cerebral infarction

    PubMed ID: 35246395

    Post‑thrombolysis trial reported increased SOD and decreased MDA (antioxidant/reperfusion marker improvements) with a Panax-containing formula.

  11. [Effect of Shenfu injection in postoperative recovery after abdominal surgery]

    PubMed ID: 17455472

    Shenfu injection raised SOD and lowered MDA after surgery, indicating antioxidant effects (multi-component product).

  12. Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial

    PubMed ID: 23613825

    RDB trial showed decreased ROS and MDA and increased GSH activity with Panax ginseng — direct antioxidant biomarker improvements.

  13. Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial

    PubMed ID: 28753932

    Red ginseng reduced micronucleus yield (less genotoxicity) — consistent with antioxidant/protective effects.

Focus & concentration (13)
  1. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity

    PubMed ID: 15982990

    Acute Panax ginseng improved a sustained-attention subtraction task and reduced mental fatigue.

  2. Efficacy of Omega-3 and Korean Red Ginseng in Children with Subthreshold ADHD: A Double-Blind, Randomized, Placebo-Controlled Trial

    PubMed ID: 32847461

    Omega‑3 plus Korean red ginseng improved ADHD symptom scores and attention measures in children (combination product).

  3. Effects of Korean red ginseng extract on behavior in children with symptoms of inattention and hyperactivity/impulsivity: a double-blind randomized placebo-controlled trial

    PubMed ID: 25369174

    Korean red ginseng produced statistically significant improvements in inattention and EEG TBR in children with ADHD symptoms.

  4. A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans

    PubMed ID: 32731478

    Beverage with ginseng increased frontal oxygenation and improved some alertness/mental fatigue measures — supports acute focus.

  5. [Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment]

    PubMed ID: 17993008

    Herbal capsule including ginseng improved memory and related cognitive measures in older adults — relevant to attentional performance.

  6. A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action

    PubMed ID: 34396468

    American ginseng improved sustained and executive attention outcomes in an RCT — clear support for improved focus.

  7. Heat-processed ginseng enhances the cognitive function in patients with moderately severe Alzheimer's disease

    PubMed ID: 22780999

    Cognitive test improvements in Alzheimer's suggest benefits for attention/focus in that population.

  8. Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle-age adults

    PubMed ID: 25778987

    Working-memory improvements in a crossover study imply improved short-term focus after American ginseng.

  9. Effects of Korean red ginseng on human gray matter volume and cognitive function: A voxel-based morphometry study

    PubMed ID: 33217050

    KRG produced modest composite cognitive improvements (attention/executive domains included), supporting focus benefits.

  10. Efficacy and Safety of Panax ginseng Sprout Extract in Subjective Memory Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

    PubMed ID: 38931306

    Cognitive trial showed memory and global cognition gains which support improved attentional function.

  11. HT1001, a proprietary North American ginseng extract, improves working memory in schizophrenia: a double-blind, placebo-controlled study

    PubMed ID: 22213250

    HT1001 improved visual working memory in schizophrenia, indicating meaningful cognitive/attention benefit in that population.

  12. Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study

    PubMed ID: 20676609

    Acute standardized American ginseng reliably improved working memory speed and attention measures in healthy adults.

  13. The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers

    PubMed ID: 11140327

    Ginkgo/ginseng combo improved working memory and contributed to composite memory gains (attention component).

Blood sugar (11)
  1. Supplementation of cheonggukjang and red ginseng cheonggukjang can improve plasma lipid profile and fasting blood glucose concentration in subjects with impaired fasting glucose

    PubMed ID: 21128827

    Red ginseng–enriched product lowered fasting blood glucose in subjects with impaired fasting glucose over 8 weeks (small RCT).

  2. [Effect of Tangyikang in improving the function of pancreatic islet beta cells in patients with latent autoimmune diabetes mellitus in adults]

    PubMed ID: 19123322

    In LADA patients a multi‑herb decoction including red ginseng improved beta‑cell function and reduced insulin dose requirements (human clinical signal).

  3. Diabetes-ameliorating effects of fermented red ginseng and causal effects on hormonal interactions: testing the hypothesis by multiple group path analysis

    PubMed ID: 23675990

    Two‑week fermented red ginseng in postmenopausal women modestly reduced HbA1c, insulin and HOMA‑IR (statistically significant but small effects).

  4. [Effect of panax quinquefolius saponin on insulin sensitivity in patients of coronary heart disease with blood glucose abnormality]

    PubMed ID: 18198636

    Panax quinquefolius saponin improved HOMA‑beta (beta‑cell function) and was associated with glucose changes in CHD patients with abnormal glucose (adjunct therapy).

  5. [Effect of renshen jianxin capsule for alleviating insulin resistance in patients with coronary heart disease and glucose tolerance impairment]

    PubMed ID: 19960983

    Renshen Jianxin Capsule (ginseng‑based) improved insulin sensitivity measures over 20 weeks, comparable to metformin in CHD patients with IGT.

  6. Effects of Panax notoginseng (Chinese ginseng) and acute exercise on postprandial glycemia in non-diabetic adults

    PubMed ID: 22499718

    Short‑term PNG lowered early postprandial glucose and 0–90 min AUC in healthy men (acute glycemic effect).

  7. Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial

    PubMed ID: 25015735

    4‑week RCT in impaired glucose regulation showed significant 2‑h postprandial glucose and AUC reductions and increased insulin.

  8. Korean red ginseng improves glucose control in subjects with impaired fasting glucose, impaired glucose tolerance, or newly diagnosed type 2 diabetes mellitus

    PubMed ID: 24456363

    12‑week RCT in IFG/IGT/new T2DM lowered early post‑load glucose (30 min) with trends for AUC reduction.

  9. Effects of Shenlian formula on microbiota and inflammatory cytokines in adults with type 2 diabetes: a double-blind randomized clinical trial

    PubMed ID: 37454261

    Shenlian formula (Huanglian + Renshen) produced significant reductions in postprandial glucose, HOMA‑IR and CRP over 12 weeks (direct glycemic/improvement evidence).

  10. Effects of ginseng berry saponins from panax ginseng on glucose metabolism of patients with prediabetes: A randomized, double-blinded, placebo-controlled, crossover trial

    PubMed ID: 39004031

    Ginseng-berry saponins reduced 2‑h postprandial glucose and improved HOMA-IR in prediabetes (well-powered RCT crossover).

  11. Efficacy and safety of red ginseng extract powder (KGC05pg) in achieving glycemic control in prediabetic Korean adults: A 12-week, single-center, randomized, double-blind, parallel-group, placebo-controlled study

    PubMed ID: 39969290

    Korean red ginseng extract modestly improved fasting/postprandial glucose and insulin-resistance markers in prediabetic adults.

Endurance (5)
  1. The utility of traditional Chinese medicine (Shenmai) in the cardiac rehabilitation after coronary artery bypass grafting: A single-center randomized clinical trial

    PubMed ID: 31779994

    Shenmai (includes ginseng) led to a clinically meaningful ~43 m greater 6‑minute walk distance at discharge—strong signal for short‑term stamina.

  2. A randomized, double-blind, multicenter, placebo-controlled clinical study on the efficacy and safety of Shenmai injection in patients with chronic heart failure

    PubMed ID: 27045864

    Shenmai injection improved 6MWD and NYHA class in heart‑failure patients over one week—improved short‑term stamina/function as adjunct.

  3. Ginseng improves pulmonary functions and exercise capacity in patients with COPD

    PubMed ID: 12814035

    G115 produced large VO2max and exercise capacity gains in COPD patients — strong endurance benefit in disease population.

  4. [Clinical study in treating qi-deficiency and blood-stasis syndrome of angina pectoris with qi xue granule]

    PubMed ID: 1301847

    Ginseng‑containing formula increased exercise time and workload (~30% increases) in angina patients.

  5. Efficacy and Safety of Panax notoginseng Saponins in the Treatment of Adults With Ischemic Stroke in China: A Randomized Clinical Trial

    PubMed ID: 37338907

    Large ischemic stroke trial with Panax notoginseng saponins improved functional independence at 3 months, plausibly reflecting increased activity/endurance capacity.

Mood balance (8)
  1. Neurocognitive effects a combined polyphenolic-rich herbal extract in healthy middle-aged adults - a randomised, double-blind, placebo-controlled study

    PubMed ID: 38512715

    Multi‑ingredient supplement including Panax improved positive affect and delayed recall vs placebo after 28 days (clinical mood outcome).

  2. Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial

    PubMed ID: 28753932

    Red ginseng improved emotional function and anxiety subscales of HRQL in chemo patients — supports mood enhancement in a clinical context.

  3. Influence of a double blind pharmacological trial on two domains of well-being in subjects with age associated memory impairment

    PubMed ID: 15374200

    9‑month ginseng‑containing vitamin complex improved self‑reported life satisfaction (mood/quality‑of‑life) in older adults.

  4. A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action

    PubMed ID: 34396468

    American ginseng improved subjective self‑assurance and reduced mental fatigue in RCT — indicates modest mood/affect benefit.

  5. Effects of sun ginseng on subjective quality of life in cancer patients: a double-blind, placebo-controlled pilot trial

    PubMed ID: 16882101

    Sun ginseng improved psychological QoL and GHQ‑12 scores in cancer patients indicating better mental health/mood.

  6. Safety and efficacy of Ninjin'yoeito along with iron supplementation therapy for preoperative anemia, fatigue, and anxiety in patients with gynecological disease: an open-label, single-center, randomized phase-II trial

    PubMed ID: 35701778

    Ninjin'yoeito + iron reduced anxiety VAS more than iron alone (direct mood/anxiety improvement).

  7. Effects of Panax Ginseng on Health-Related Quality of Life in Patients with Non-Metastatic Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Ginseng for HRQOL in Breast Cancer

    PubMed ID: 37218691

    Prevention of decline in emotional well‑being during chemotherapy supports mood benefit (small RCT).

  8. Effect of Hydroponically Grown Red Panax Ginseng on Perceived Stress Level, Emotional Processing, and Cognitive Functions in Moderately Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study

    PubMed ID: 40289951

    Hydroponic red ginseng reduced negative affect (PANAS‑N) and perceived stress in a randomized trial.

Stress & Anxiety (5)
  1. Effects of ginseng on peripheral blood mitochondrial DNA copy number and hormones in men with metabolic syndrome: A randomized clinical and pilot study

    PubMed ID: 26860800

    Red ginseng lowered serum cortisol in metabolic‑syndrome men—objective marker of reduced physiological stress.

  2. Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial

    PubMed ID: 28753932

    Red ginseng improved emotional function and anxiety subscales of HRQL in chemo patients — supports stress/anxiety symptom relief.

  3. Effect of Hydroponically Grown Red Panax Ginseng on Perceived Stress Level, Emotional Processing, and Cognitive Functions in Moderately Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study

    PubMed ID: 40289951

    Hydroponic red ginseng significantly reduced perceived stress (PSS) and negative affect versus placebo in moderately stressed adults.

  4. Effects of Panax Ginseng on Health-Related Quality of Life in Patients with Non-Metastatic Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Ginseng for HRQOL in Breast Cancer

    PubMed ID: 37218691

    Improvement/preservation of emotional well‑being during chemotherapy indicates stress-related QoL benefit (small RCT).

  5. Safety and efficacy of Ninjin'yoeito along with iron supplementation therapy for preoperative anemia, fatigue, and anxiety in patients with gynecological disease: an open-label, single-center, randomized phase-II trial

    PubMed ID: 35701778

    NYT (contains ginseng) plus iron reduced anxiety (VAS‑A) more than iron alone in preop patients (direct stress/anxiety relief).

Sleep quality (2)
  1. Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial

    PubMed ID: 28753932

    Red ginseng improved the sleep subscale of HRQL in chemotherapy survivors vs placebo — evidence for improved sleep quality in this population.

  2. Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study

    PubMed ID: 17454163

    3‑month multi‑herb formula including American ginseng markedly reduced hot flushes/night sweats and improved sleep quality in menopausal women (randomized double‑blind).

Skin health (1)
  1. Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin: a randomized, double-blind, placebo-controlled study

    PubMed ID: 20041778

    24‑week RCT of a red ginseng‑containing herbal mixture reduced facial wrinkles and increased type I procollagen expression vs placebo (objective skin outcomes; multi‑herb).

Weight management (1)
  1. Effects of Shenlian formula on microbiota and inflammatory cytokines in adults with type 2 diabetes: a double-blind randomized clinical trial

    PubMed ID: 37454261

    Shenlian formula decreased BMI over 12 weeks in T2DM patients (direct modest weight/BMI effect).

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Being studied right now

Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.