Epigallocatechin Gallate
19 benefits mapped to clinical evidence across supplements.
Dose per serving from products
167 products in our catalogue print how much Epigallocatechin Gallate a serving holds.
Most common: 100 mg to 250 mg, 37% of 167 products.
| Dose per serving | Products |
|---|---|
| 10 mg or less | 7 |
| 10 mg to 25 mg | 18 |
| 25 mg to 50 mg | 26 |
| 50 mg to 100 mg | 34 |
| 100 mg to 250 mg | 61 |
| 250 mg to 500 mg | 19 |
| over 500 mg | 2 |
Dose per serving from research
89 study groups in 55 studies say how much Epigallocatechin Gallate participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg and 500 mg to 1 g, 36% of 89 study groups each.
| Daily dose | Study groups |
|---|---|
| 100 mg or less | 5 |
| 100 mg to 250 mg | 12 |
| 250 mg to 500 mg | 32 |
| 500 mg to 1 g | 32 |
| 1 g to 2.5 g | 8 |
Commonly used together
38 of 91 study groups took Epigallocatechin Gallate with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Green Tea Extract | 16 |
| Caffeine | 8 |
| Resveratrol | 7 |
Benefit Evidence
Lipids ↓; heart risk
BP/HRV improved; heart risk
Endothelial/oxidation improved
Inflammation/lesions ↓; −22% RID
Pigmentation/scar repair ↑
Redness/angiogenesis ↓; −14.6% HIF-1α
Lipids ↓; heart risk
BP/HRV improved; heart risk
Endothelial/oxidation improved
Inflammation/lesions ↓; −22% RID
Pigmentation/scar repair ↑
Redness/angiogenesis ↓; −14.6% HIF-1α
Research sources
Metabolism (11)
- The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats
PubMed ID: 32729662
Obese rat model showed improved serum glucose and lipids with EGCG — consistent metabolic benefit in animals.
- Effect of epigallocatechin gallate on the body composition and lipid profile of down syndrome individuals: Implications for clinical management
PubMed ID: 31229326
12-month trial in Down syndrome males showed reduced weight/body fat and correlated lipid improvements — metabolic relevance.
- Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women
PubMed ID: 28589947
EGCG+resveratrol changed gut microbiota and linked baseline composition to increased fat oxidation in men.
- Dietary epigallocatechin 3-gallate supplement improves maternal and neonatal treatment outcome of gestational diabetes mellitus: a double-blind randomised controlled trial
PubMed ID: 28266082
500 mg/day EGCG improved maternal glucose/insulin measures in gestational diabetes RCT — direct metabolic effect.
- Effect of gender on the metabolic impact of a commercially available thermogenic drink
PubMed ID: 20508469
Thermogenic multi‑ingredient (includes EGCG) produced gender‑differentiated increases in REE and lipolysis markers.
- Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects
PubMed ID: 23271695
Multi‑ingredient supplement containing EGCG improved insulin resistance and some metabolic markers (attribution uncertain).
- Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 26093535
12‑week high‑dose EGCG produced modest weight/waist reductions and favorable hormonal (ghrelin/adiponectin) changes.
- Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial
PubMed ID: 27194304
EGCG+resveratrol raised muscle mitochondrial oxidative capacity and shifted RQ toward more fat oxidation.
- Effects of Timing of Acute and Consecutive Catechin Ingestion on Postprandial Glucose Metabolism in Mice and Humans
PubMed ID: 32098219
Timing-dependent postprandial glucose/insulin effects in humans and animals indicate metabolic modulation by catechins.
- The therapeutic role and potential mechanism of EGCG in obesity-related precocious puberty as determined by integrated metabolomics and network pharmacology
PubMed ID: 37334310
Robust metabolomics changes in obese girls implicate lipid metabolism, insulin-resistance pathways and multiple metabolic targets after EGCG.
- Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity
PubMed ID: 39182247
EGCG+resveratrol preserved/increased whole-body and postprandial fat oxidation and raised muscle oxidative capacity—strong metabolic signal (though combined treatment).
Heart health (8)
- Epigallocatechin gallate enhances sympathetic heart rate variability and decreases blood pressure in obese subjects: a randomized control trial
PubMed ID: 39285220
Randomized trial in obese adults showed clinically meaningful reductions in systolic and diastolic BP with EGCG (150 mg BID).
- Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients
PubMed ID: 22581111
Three‑month RCT in obese patients showed improvements in TC/TG/LDL and HDL, favorable for heart health.
- Can EGCG reduce abdominal fat in obese subjects?
PubMed ID: 17906193
EGCG plus exercise lowered resting heart rate and improved glucose in some participants (cardiovascular-relevant effects).
- Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease
PubMed ID: 17536120
Single 300 mg EGCG acutely improved flow-mediated dilation in CAD patients (~21% relative improvement), a direct endothelial/heart-health marker.
- Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women
PubMed ID: 22246619
Randomized trial in postmenopausal women lowered LDL and TC over 2 months—supports cholesterol/heart risk modulation.
- Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial
PubMed ID: 27806972
Large RCT (12 months) found modest but significant reductions in total and LDL cholesterol—cardiovascular risk relevant.
- Epigallocatechin gallate enhances treatment efficacy of oral nifedipine against pregnancy-induced severe pre-eclampsia: A double-blind, randomized and placebo-controlled clinical study
PubMed ID: 28726273
In severe pre-eclampsia, EGCG added to nifedipine sped BP control and prolonged interval to hypertensive recurrence — direct cardiovascular benefit.
- Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial
PubMed ID: 34187117
T2DM RCT showed reductions in MAP/DBP and improved lipids — favorable cardiac risk factor changes.
Inflammation (11)
- Assessing the analgesic efficacy of oral epigallocatechin-3-gallate on epidural catheter analgesia in patients after surgical stabilisation of multiple rib fractures: a prospective double-blind, placebo-controlled clinical trial
PubMed ID: 32749173
Post-op pain reduction and improved respiratory measures likely reflect reduced local/systemic inflammation.
- Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients
PubMed ID: 22581111
GTE lowered lipid and improved antioxidant status, consistent with reduced inflammatory milieu in obese participants.
- Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation
PubMed ID: 26521072
EGCG reduced oxidative burst/NOX activity in monocytes, a pathway tied to inflammatory processes.
- Effects of quercetin and EGCG on mitochondrial biogenesis and immunity
PubMed ID: 19516153
Trial in cyclists showed blunted exercise‑induced increases in CRP/IL‑6/IL‑10 with EGCG+quercetin (anti‑inflammatory signal).
- Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome
PubMed ID: 20605696
Green tea reduced serum amyloid A (an inflammatory/pro-atherogenic marker) in obese subjects (direct inflammatory biomarker reduction).
- 'Benifuuki' green tea containing o-methylated catechin reduces symptoms of Japanese cedar pollinosis: a randomized, double-blind, placebo-controlled trial
PubMed ID: 24561771
Benifuuki green tea reduced allergic rhinitis symptoms and suppressed eosinophil increases—anti‑inflammatory in allergy.
- The use of green tea polyphenols for treating residual albuminuria in diabetic nephropathy: A double-blind randomised clinical trial
PubMed ID: 27320846
Significant reductions in albuminuria accompanied by lower TNF‑α, indicating anti‑inflammatory effects in diabetic kidney disease.
- A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin
PubMed ID: 30822414
Topical EGCG reduced mast cells and angiogenic markers and lowered inflammatory signals in scar model.
- A prospective, three-arm, randomized trial of EGCG for preventing radiation-induced esophagitis in lung cancer patients receiving radiotherapy
PubMed ID: 30898322
EGCG reduced severity and symptoms of radiation-induced esophagitis, indicating anti-inflammatory mucosal protection.
- The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats
PubMed ID: 32729662
Animal study showed reductions in inflammatory cytokines (IL-6, TNF-α) with EGCG.
- Possible Role of Butyrylcholinesterase in Fat Loss and Decreases in Inflammatory Levels in Patients with Multiple Sclerosis after Treatment with Epigallocatechin Gallate and Coconut Oil: A Pilot Study
PubMed ID: 34579104
Combined intervention including EGCG decreased IL-6 in MS patients, indicating an anti-inflammatory signal though causality to EGCG is uncertain.
Cell health (9)
- Green tea extracts for the prevention of metachronous colorectal polyps among patients who underwent endoscopic removal of colorectal adenomas: A randomized clinical trial
PubMed ID: 28209333
RCT showed significant reduction in recurrent colorectal adenomas — strong cellular/anticarcinogenic protection signal.
- Metabolomics strategy comprehensively unveils the effect of catechins intervention on the biomarkers of exposure to acrylamide and biomarkers of cardiometabolic risk
PubMed ID: 36191485
Catechin supplementation promoted excretion of acrylamide metabolites and favorable metabolomic shifts consistent with reduced cellular toxic burden.
- Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients
PubMed ID: 22581111
Improved antioxidant status in humans supports cellular protection from oxidative damage.
- Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation
PubMed ID: 26521072
Strong biomarker evidence: marked reduction of NOX activation in monocytes indicates cellular oxidative‑stress protection.
- Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions
PubMed ID: 14512803
Clinical regression of HPV-related cervical lesions suggests cellular/proliferative protective effects.
- A Phase II Randomized, Double-blind, Presurgical Trial of Polyphenon E in Bladder Cancer Patients to Evaluate Pharmacodynamics and Bladder Tissue Biomarkers
PubMed ID: 28325826
Dose-dependent EGCG tissue accumulation with decreased proliferation (PCNA) and clusterin in bladder tissue.
- A prospective, three-arm, randomized trial of EGCG for preventing radiation-induced esophagitis in lung cancer patients receiving radiotherapy
PubMed ID: 30898322
Reduced radiation esophagitis and tissue injury in cancer patients indicates mucosal cellular protection.
- Phenolic acid concentrations in plasma and urine from men consuming green or black tea and potential chemopreventive properties for colon cancer
PubMed ID: 23319439
Human green‑tea intake increased colonic phenolic metabolites that enhanced antiproliferative effects in colon cells in vitro.
- The use of green tea polyphenols for treating residual albuminuria in diabetic nephropathy: A double-blind randomised clinical trial
PubMed ID: 27320846
Marked reduction in albuminuria plus lowered DKK‑1 and TNF‑α suggests biologic protection of renal tissue in diabetes.
Blood sugar (7)
- Dietary epigallocatechin 3-gallate supplement improves maternal and neonatal treatment outcome of gestational diabetes mellitus: a double-blind randomised controlled trial
PubMed ID: 28266082
Gestational diabetes RCT showed improved maternal glucose and insulin measures with daily EGCG.
- Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial
PubMed ID: 34187117
T2DM trial also reported lipid and BP improvements and overall improved antioxidant capacity; glycemic effects secondary but plausible.
- Effects of Timing of Acute and Consecutive Catechin Ingestion on Postprandial Glucose Metabolism in Mice and Humans
PubMed ID: 32098219
Human and animal data showed greater glucose-lowering (and insulin changes) when catechins taken in the evening.
- The therapeutic role and potential mechanism of EGCG in obesity-related precocious puberty as determined by integrated metabolomics and network pharmacology
PubMed ID: 37334310
Pathway enrichment included insulin-resistance pathways; metabolomic shifts suggest potential glycemic/insulin modulation.
- Green Tea Extract and Catechol-O-Methyltransferase Genotype Modify Fasting Serum Insulin and Plasma Adiponectin Concentrations in a Randomized Controlled Trial of Overweight and Obese Postmenopausal Women
PubMed ID: 26581683
12‑month decaffeinated GTE lowered fasting insulin modestly in participants with baseline hyperinsulinemia (subgroup effect).
- Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients
PubMed ID: 22581111
GTE reduced fasting glucose slightly in an obese cohort after 3 months.
- Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects
PubMed ID: 23271695
Multi‑ingredient product containing EGCG reduced HOMA (improved insulin resistance) in overweight adults (attribution uncertain).
Immune support (7)
- A randomized clinical study of tea catechin inhalation effects on methicillin-resistant Staphylococcus aureus in disabled elderly patients
PubMed ID: 16461248
Inhaled catechin solution reduced MRSA sputum counts vs saline in elderly patients (direct antimicrobial/clinical effect).
- 'Benifuuki' green tea containing o-methylated catechin reduces symptoms of Japanese cedar pollinosis: a randomized, double-blind, placebo-controlled trial
PubMed ID: 24561771
Benifuuki green tea reduced seasonal allergic rhinitis symptoms and suppressed eosinophil increases—immune/allergic modulation.
- Prevention of Acute Upper Respiratory Infections by Consumption of Catechins in Healthcare Workers: A Randomized, Placebo-Controlled Trial
PubMed ID: 31861349
Large RCT showing ~50% reduction in upper respiratory infections with catechin-containing beverage.
- The use of green tea polyphenols for treating residual albuminuria in diabetic nephropathy: A double-blind randomised clinical trial
PubMed ID: 27320846
In diabetic kidney disease GTP reduced albuminuria and TNF‑α, indicating anti‑inflammatory/immunomodulatory effects.
- Effects of quercetin and EGCG on mitochondrial biogenesis and immunity
PubMed ID: 19516153
Human study showed increased granulocyte oxidative burst activity and blunted exercise‑induced inflammatory markers with EGCG+quercetin.
- Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation
PubMed ID: 26521072
EGCG adjunct in MS lowered NOX activation in monocytes, indicating immunomodulation of peripheral immune cells.
- Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions
PubMed ID: 14512803
Green tea extracts (including EGCG) produced substantially higher clinical responses in HPV-related cervical lesions vs no treatment.
Weight management (7)
- Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 26093535
12‑week high‑dose EGCG produced small but significant reductions in weight and waist circumference.
- Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome
PubMed ID: 20595643
Eight weeks of green tea (beverage/extract) yielded ~2 kg weight loss in obese subjects (clinically meaningful short-term effect).
- Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation
PubMed ID: 16076989
Green tea+caffeine aided weight/fat maintenance after weight loss in habitual low‑caffeine users (effect modified by caffeine habit).
- The combined effect of green tea and α-glucosyl hesperidin in preventing obesity: a randomized placebo-controlled clinical trial
PubMed ID: 34561541
Repeated entry (same study) — strong evidence for preventing weight/BMI increases; included here to emphasize direct weight‑management trial evidence.
- The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats
PubMed ID: 32729662
Obese rats showed metabolic improvements and lifespan gain with EGCG and reduced adiposity-related markers.
- Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity
PubMed ID: 39182247
Preserved/increased fat oxidation and improved muscle oxidative capacity in overweight adults (EGCG+resveratrol) supports potential weight-management mechanisms.
- Effect of epigallocatechin gallate on the body composition and lipid profile of down syndrome individuals: Implications for clinical management
PubMed ID: 31229326
12-month RCT in Down syndrome males produced modest but significant reductions in weight and body fat with EGCG.
Antioxidant (7)
- N-Oleoyl-Phosphatidyl-Ethanolamine and Epigallo Catechin-3-Gallate Mitigate Oxidative Stress in Overweight and Class I Obese People on a Low-Calorie Diet
PubMed ID: 31928490
NOPE‑EGCG improved oxidative stress markers (↓Ox‑LDL, ↑antioxidant lag time) over 2 months.
- Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial
PubMed ID: 34187117
RCT in T2DM showed increased total antioxidant capacity after 2 months of EGCG.
- The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats
PubMed ID: 32729662
Animal study reported reduced oxidative stress markers with EGCG.
- Effects of quercetin and EGCG on mitochondrial biogenesis and immunity
PubMed ID: 19516153
Multi‑ingredient supplement containing EGCG reduced exercise‑related inflammatory/oxidative responses.
- Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation
PubMed ID: 26521072
EGCG adjunct markedly reduced NOX activation in monocytes (reduced oxidative stress biomarkers).
- Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients
PubMed ID: 22581111
RCT showed increased total antioxidant status and improved oxidative markers in obese patients.
- Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement
PubMed ID: 15585768
GTE supplement produced higher plasma catechins and a modest increase in plasma antioxidant activity vs brewed tea.
Cholesterol (4)
- Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial
PubMed ID: 27806972
Large RCT with 12‑month follow‑up showed significant modest reductions in total and LDL cholesterol.
- Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women
PubMed ID: 22246619
Randomized trial reported −7.9% and −6.6% LDL reductions with PPE doses—direct cholesterol benefit.
- Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients
PubMed ID: 22581111
RCT found significant decreases in total cholesterol and triglycerides and LDL improvements with GTE in obese patients.
- Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial
PubMed ID: 34187117
T2DM RCT found decreases in triglycerides/total cholesterol and improved atherogenic index after EGCG.
Skin health (5)
- Efficacy of Epigallocatechin-3-Gallate in Preventing Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy: A Double-Blind, Placebo-Controlled, Phase 2 Randomized Clinical Trial
PubMed ID: 35648426
Large RCT showed topical EGCG spray substantially reduced incidence and severity of radiation dermatitis vs placebo.
- Does supplementation with green tea extract improve acne in post-adolescent women? A randomized, double-blind, and placebo-controlled clinical trial
PubMed ID: 27062963
Oral decaffeinated GTE reduced inflammatory acne lesions in adult women in a randomized trial.
- Topical lipophilic epigallocatechin-3-gallate on herpes labialis: a phase II clinical trial of AverTeaX formula
PubMed ID: 26548726
Topical EGCG formulation substantially shortened cold‑sore symptoms—relevant to skin/mucosal healing.
- Randomized, controlled, double-blind clinical study evaluating the safety and efficacy of MD2011001 cream in mild-to-moderate atopic dermatitis of the face and neck in children, adolescents and adults
PubMed ID: 26652026
Topical cream containing EGCG accelerated improvement in atopic dermatitis vs placebo (multi‑ingredient product).
- A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin
PubMed ID: 30822414
Topical EGCG reduced inflammation/angiogenesis and improved scar thickness, hydration, and elasticity in volunteers.
Oral health (5)
- Efficacy of green tea and its extract, epigallocatechin-3-gallate, in the reduction of cariogenic microbiota in children: a randomized clinical trial
PubMed ID: 32361019
One-minute EGCG mouthwash produced ~80% reduction in mutans streptococci and strong lactobacilli reductions — high-quality oral antimicrobial evidence.
- Evaluation of bioflavonoids on the immediate and delayed microtensile bond strength of self-etch and total-etch adhesive systems to sound dentin
PubMed ID: 29652002
Ex vivo dentin study showed improved immediate adhesive bond strength with EGCG—relevant but non‑clinical.
- Topical lipophilic epigallocatechin-3-gallate on herpes labialis: a phase II clinical trial of AverTeaX formula
PubMed ID: 26548726
Randomized trial halved cold‑sore episode length and markedly reduced blistering/itching times—strong oral/mucosal benefit.
- A randomized clinical study of tea catechin inhalation effects on methicillin-resistant Staphylococcus aureus in disabled elderly patients
PubMed ID: 16461248
Inhaled tea catechin solution significantly reduced MRSA sputum counts, indicating antimicrobial effects in the respiratory/oral-related tract.
- [Pilot study of the effect of green tea extractive epigallocatechin-3-gallate on degradation of collagen in dental erosion]
PubMed ID: 23173326
Topical EGCG reduced dentine collagen breakdown marker (ICTP) in people with dental erosion (clinical pilot).
Blood circulation (4)
- Epigallocatechin gallate enhances treatment efficacy of oral nifedipine against pregnancy-induced severe pre-eclampsia: A double-blind, randomized and placebo-controlled clinical study
PubMed ID: 28726273
Faster BP control and longer interval to hypertensive crisis indicate improved short-term circulatory outcomes in pre-eclampsia.
- Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease
PubMed ID: 17536120
Acute improvement in brachial artery flow-mediated dilation in CAD patients demonstrates strong short-term circulatory benefit.
- Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment
PubMed ID: 29050464
Ex vivo human blood showed EGCG reduced ADP-/collagen‑induced platelet aggregation and shear adhesion, supporting circulation/antithrombotic effects.
- Epigallocatechin gallate enhances sympathetic heart rate variability and decreases blood pressure in obese subjects: a randomized control trial
PubMed ID: 39285220
EGCG lowered blood pressure and altered HRV toward sympathetic dominance, indicating circulatory/autonomic effects.
Focus & concentration (4)
- Stress-Reducing Function of Matcha Green Tea in Animal Experiments and Clinical Trials
PubMed ID: 30308973
Matcha (contains EGCG plus theanine/Arg) reduced state anxiety and salivary α‑amylase in students, supporting mood/stress reduction.
- Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial
PubMed ID: 27302362
EGCG plus cognitive training improved inhibitory control and functional academics, which can support focus/mood‑related function.
- The Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patients
PubMed ID: 31979305
MS trial reported reduced state anxiety and improved function in intervention group receiving EGCG + coconut oil.
- A Randomized, Double-Blind, Placebo-Controlled Trial of a Polyphenol Botanical Blend on Sleep and Daytime Functioning
PubMed ID: 33809544
Polyphenol blend containing EGCG produced modest improvements in subjective sleep quality and sustained attention measures—supports mood/attention benefits (blend context).
Exercise recovery (3)
- Effects of quercetin and EGCG on mitochondrial biogenesis and immunity
PubMed ID: 19516153
Supplement with EGCG+quercetin blunted exercise‑induced inflammatory markers and altered granulocyte responses in cyclists.
- Assessing the analgesic efficacy of oral epigallocatechin-3-gallate on epidural catheter analgesia in patients after surgical stabilisation of multiple rib fractures: a prospective double-blind, placebo-controlled clinical trial
PubMed ID: 32749173
Adjunct EGCG improved pain and lung function after thoracic surgery, consistent with enhanced recovery/rehabilitation.
- Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial
PubMed ID: 27194304
Increased muscle oxidative capacity and greater fat oxidation indicate better exercise fuel handling and recovery potential.
Healthy aging (2)
- Effect of matcha green tea on cognitive functions and sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
PubMed ID: 39213264
Year‑long matcha trial in older adults improved social‑cognitive (emotion recognition) function and tended to improve sleep, suggesting domain‑specific aging benefits.
- The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats
PubMed ID: 32729662
Obese rat study reported ~13% increased median lifespan with EGCG and reduced age-related metabolic/inflammatory markers.
Brain health (2)
- Effect of matcha green tea on cognitive functions and sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
PubMed ID: 39213264
Longer trial in older adults with mild cognitive decline produced domain‑specific cognitive improvement (emotion recognition).
- Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial
PubMed ID: 27302362
Phase 2 RCT demonstrated cognitive and adaptive function improvements with EGCG plus cognitive training.
Mental clarity (2)
- Effect of matcha green tea on cognitive functions and sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
PubMed ID: 39213264
12‑month matcha in older adults with mild cognitive decline improved facial‑emotion recognition (domain‑specific cognitive gain).
- Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial
PubMed ID: 27302362
Phase 2 RCT: EGCG plus cognitive training significantly improved memory, inhibitory control and adaptive daily skills.
Liver support (2)
- Novel combined single dose anti-hepatitis C therapy: a pilot study
PubMed ID: 33633233
EGCG-containing single-tablet produced comparable antiviral SVR12 in genotype-4 HCV and attenuated ribavirin-associated hemoglobin decline—relevant to hepatic antiviral therapy context.
- Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
PubMed ID: 36678191
Short-term high-EGCG dosing in reproductive-aged women showed no clinically significant liver enzyme abnormalities, supporting hepatic tolerability.
Energy & Fatigue (1)
- Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial
PubMed ID: 27194304
Shift toward greater fat oxidation and increased mitochondrial capacity could favor energy balance over time.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Epigallocatechin Gallate
Search all224 products whose verified label declares Epigallocatechin Gallate — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.