Vitamin D

PubMed ID: 25929192

Randomized trial in postmenopausal osteoporosis: alendronate + cholecalciferol increased lumbar spine and hip BMD more than calcitriol—clear bone benefit with vitamin D supplementation in combination therapy.

PubMed ID: 20709302

Observational study in female runners: higher dietary vitamin D (with milk) associated with greater bone gains and fewer stress fractures.

PubMed ID: 20646099

Intermittent high‑dose cholecalciferol corrected deficiency and normalized PTH better than low dose — supports bone health via improved vitamin D status.

PubMed ID: 20148911

Two years of calcium supplements lowered PTH and modestly improved lumbar and hip BMD; vitamin D status influenced some responses.

PubMed ID: 20861405

Daily 250–500 IU in infants raised 25(OH)D substantially by 6 weeks — biochemical support for early bone development.

PubMed ID: 20823895

Monthly/bimonthly vitamin D in adolescents raised 25(OH)D and lowered PTH safely — supports bone health in growing individuals.

PubMed ID: 20193095

Large RCT in vitamin D‑deficient young women: vitamin D + calcium raised 25(OH)D, lowered PTH and increased femoral bone measures.

PubMed ID: 21153900

30‑month fortified‑dairy (calcium + vitamin D) maintained 25(OH)D, lowered bone resorption marker and improved total body BMD in postmenopausal women.

PubMed ID: 20544178

Randomized trial in peripubertal girls showed significant increases in trabecular/cortical bone density and strength with calcium + vitamin D.

PubMed ID: 20298784

Eldecalcitol (vitamin D analog) produced clear dose‑dependent suppression of bone resorption markers — strong evidence for bone effects from active vitamin D analogs.

PubMed ID: 20204604

Population RCT of vitamin D (800 IU) + calcium showed small but significant preservation/increase in total body BMD, stronger in compliant users.

PubMed ID: 20200964

Large trial of vitamin D (800 IU) + calcium showed modest, non‑significant reductions in fractures — suggests some bone benefit but limited/statistically weak.

PubMed ID: 18847321

Controlled trial (~800 IU/day) prevented winter 25(OH)D decline, suppressed PTH rise and stabilized bone turnover in healthy men — supports bone health.

PubMed ID: 19565176

Population screening increased vitamin D use and was associated with a substantial reduction in fractures, though multifactorial.

PubMed ID: 20086314

800 IU/day increased 25(OH)D and lowered PTH in elderly—biomarker improvements supportive of bone health.

PubMed ID: 19647104

RCTS in adolescents showed VDR genotype modifies skeletal response to vitamin D supplementation—direct evidence on bone outcomes.

PubMed ID: 19297462

Provides dose estimates to maintain 25(OH)D thresholds that underpin bone health in older adults.

PubMed ID: 19262561

Adding active vitamin D to calcium+vitamin D produced significantly greater lumbar spine BMD gains in elderly women.

PubMed ID: 19117833

High‑dose bimonthly vitamin D effectively raised 25(OH)D in children — a necessary step to support bone health.

PubMed ID: 19244376

Daily 5000 IU via bread produced a very large rise in 25(OH)D, reduced PTH and increased BMD z‑scores in nursing‑home residents—direct, strong bone benefit.

PubMed ID: 19185400

Vitamin D3 plus calcium in elderly CKD women increased 25(OH)D and reduced iPTH across eGFR strata—meaningful for bone health.

PubMed ID: 18996761

Randomized trial after gastric bypass: weekly 50,000 IU corrected deficiency and attenuated hip BMD loss — direct bone benefit from vitamin D.

PubMed ID: 18296324

Two-year randomized school-based supplementation (calcium ± vitamin D) increased size-corrected total-body and leg BMD in 10-year-old girls.

PubMed ID: 18433305

Very large RCT: daily calcium + 800 IU vitamin D reduced stress-fracture incidence in female navy recruits — strong, clinically relevant bone benefit.

PubMed ID: 19035501

Pediatric RCT in juvenile arthritis: calcium + vitamin D associated with small but significant increases in total body BMD and PTH reduction (vitamin D present in regimen).

PubMed ID: 17493196

Alendronate plus active vitamin D (calcitriol) yielded substantially greater spine BMD gains and marked PTH suppression—strong evidence for active vitamin D improving bone outcomes when used with bisphosphonate.

PubMed ID: 17216477

Combination of alendronate with an active vitamin D analogue produced substantially larger BMD gains than alendronate+plain vitamin D or analog alone—supports role of active vitamin D in bone response.

PubMed ID: 17874029

Nursing-home dosing trial: oral vitamin D regimens raised serum 25(OH)D and lowered PTH—key intermediates for bone health.

PubMed ID: 17823446

Dietary intervention with vitamin D–fortified dairy produced greater BMD gains at pelvis/spine/total body than controls—supports bone benefit in a dietary program.

PubMed ID: 17616788

Post-fracture RCT: Ca+D (high dose) increased lumbar spine BMD and lowered bone turnover over 12 months (clinically meaningful change; combined therapy).

PubMed ID: 17243866

Older-women trial of D+Ca+vitamin K produced a modest, site-specific increase in wrist bone mineral content and expected 25(OH)D/PTH changes.

PubMed ID: 18089701

Randomized trial: calcium with vitamin D preserved hip BMD and reduced bone turnover over 5 years in older women—strong direct skeletal evidence.

PubMed ID: 16753014

Dose‑response vitamin D3 supplementation in adolescent girls increased site-specific bone mineral content and serum 25‑OH D—direct bone benefit.

PubMed ID: 16231362

Calcium plus vitamin D improved tibial bone measures in anorexia nervosa over 3 months compared with control—direct but short‑term and combined therapy.

PubMed ID: 16391587

High-dose vitamin D2 rapidly raised 25OHD and lowered PTH and a bone marker in postmenopausal women — supports bone health via biochemical repletion.

PubMed ID: 16431255

Paricalcitol (vitamin D analogue) markedly lowered PTH in CKD with good biochemical control — relevant to preserving bone in secondary hyperparathyroidism.

PubMed ID: 17019520

Calcitriol (active vitamin D) combined with alendronate improved lumbar spine BMD and reduced resorption markers — strong direct bone benefit.

PubMed ID: 16508700

Vitamin D (800 IU) + calcium reduced falls and improved balance in institutionalized older women — likely contributes to fracture prevention and bone health.

PubMed ID: 16725396

Two-year Ca+D3 fortified milk (800 IU/day vitamin D3) preserved femoral cortical vBMD and geometry in older men >62, showing structural bone benefits.

PubMed ID: 16782422

Children with galactosemia receiving Ca + vitamin K1 + vitamin D3 had improved lumbar spine BMC; bone mass improved though multiple nutrients were given.

PubMed ID: 16481635

Large RCT in postmenopausal women: Ca (1000 mg) + vitamin D (400 IU) produced a small but significant hip BMD increase (+1.06%), direct evidence for bone benefit.

PubMed ID: 15840055

Alfacalcidol prevented post-transplant bone loss and lowered iPTH vs control — direct bone benefit from an active vitamin D compound.

PubMed ID: 16283320

Alfacalcidol produced significantly greater lumbar spine BMD increases than standard vitamin D+calcium — direct evidence for vitamin D analog benefit on bone density.

PubMed ID: 16321186

Alfacalcidol (vitamin D analog) plus calcium prevented glucocorticoid-induced bone loss — direct clinically relevant bone-protective effect.

PubMed ID: 16189633

Direct randomized comparison of calcitriol vs vitamin D analog (OCT) in dialysis patients demonstrated suppression of PTH and reduced bone turnover — strong, direct relevance to bone health.

PubMed ID: 15972580

Active vitamin D analog (ED‑71) randomized trial produced clear, dose‑related lumbar and hip BMD increases (direct vitamin D sterol effect).

PubMed ID: 16278262

Year‑long vitamin D replacement in schoolgirls improved site‑specific BMD/BMC and lean mass, especially premenarcheally.

PubMed ID: 15883444

Large randomized school trial showed Ca+D milk improved cortical bone geometry and lowered PTH/turnover markers in girls.

PubMed ID: 16007329

Sunlight exposure markedly increased 25‑OH D, improved BMD and substantially reduced fractures in elderly women with AD.

PubMed ID: 15807187

Alfacalcidol (active vitamin D) in hemodialysis patients significantly suppressed PTH and bone turnover markers — relevant to bone/mineral management.

PubMed ID: 16382319

Randomized pediatric trial: calcium + vitamin D prophylaxis significantly reduced steroid‑associated bone loss.

PubMed ID: 16491287

RCT in older men: D3 (800 IU/d in fortified milk) raised 25(OH)D, lowered PTH and reduced bone loss at key sites.

PubMed ID: 15668602

Vitamin D‑fortified milk increased serum 25OHD and reduced bone resorption markers in postmenopausal women.

PubMed ID: 15704046

Calcium plus vitamin D in Crohn's patients improved BMD over 24 months (vitamin D part of the regimen).

PubMed ID: 14712427

Alfacalcidol prevented early steroid‑induced lumbar spine bone loss in patients starting prednisolone.

PubMed ID: 15031343

Alfacalcidol (active vitamin D) produced marked spine/femoral BMD increases and large PTH suppression in CRF patients.

PubMed ID: 15587751

Calcitriol increased BMD and reduced bone turnover markers in postmenopausal osteoporosis.

PubMed ID: 15112179

Doxercalciferol (active analog) strongly lowered PTH and bone turnover markers in CKD—relevant to bone health.

PubMed ID: 15265162

Alfacalcidol in children/adolescents post-kidney transplant greatly improved spine BMD vs control.

PubMed ID: 15663548

Oxacalcitriol produced strong dose-dependent PTH suppression in dialysis patients — supports bone-related endocrine effects.

PubMed ID: 14695863

Elderly hip-fracture RCT: vitamin D (oral or injected) with calcium raised 25(OH)D, suppressed PTH, modestly increased BMD and reduced falls.

PubMed ID: 14717945

Intermittent calcitriol after kidney transplant prevented proximal femur bone loss and lowered PTH rapidly.

PubMed ID: 15221494

Alfacalcidol plus calcium lowered PTH and increased lumbar BMD in elderly osteoporotic women (randomized data).

PubMed ID: 15295946

Calcium plus vitamin D associated with very small increases in mandibular bone mass over years (postmenopausal women).

PubMed ID: 15502727

Calcitriol+calcium after transplant attenuated bone loss and produced BMD gains at hip and wrist vs placebo.

PubMed ID: 14973216

Calcitriol limited bone loss after heart transplant vs untreated patients, though inferior to alendronate and with hypercalciuria risk.

PubMed ID: 15230999

Vitamin D–fortified milk in preteen girls gave larger bone mineral accretion and BMD gains in a large RCT.

PubMed ID: 15187195

Calcitriol and analogue had similar effects on PTH, calcium and bone markers in dialysis patients — direct active vitamin D bone outcomes.

PubMed ID: 15386160

Vitamin D3 (800 IU) + calcium increased BMD at the fracture site by week 6 vs placebo — direct evidence of local bone benefit.

PubMed ID: 15501704

Large randomized trial showing daily calcium + vitamin D prevented small annual bone loss in peri/postmenopausal women.

PubMed ID: 15231008

Winter vitamin D3 + calcium prevented normal seasonal bone turnover rise and bone loss in healthy adults — randomized evidence of bone preservation.

PubMed ID: 13680141

Alfacalcidol modestly increased spine BMD in men over 3 years (direct active vitamin D effect on bone).

PubMed ID: 14513268

Randomized trial: alfacalcidol (active vitamin D analogue) produced greater BMD gains and large fracture reductions vs vitamin D3 in glucocorticoid‑induced osteoporosis.

PubMed ID: 14569109

Alfacalcidol + calcium prevented early bone loss and lowered PTH after renal transplant — clear, direct bone benefit from an active vitamin D compound.

PubMed ID: 12929879

Vitamin D + calcium was necessary to heal rickets/osteomalacia in adolescents—clear, direct bone benefit.

PubMed ID: 25694350

Dose‑response trial showed dose‑dependent rises in 25(OH)D and corresponding decreases in PTH — supports mineral/bone physiology.

PubMed ID: 17656221

Observational data in men on ADT showed calcium/vitamin D use associated with higher BMD Z‑scores—supports bone benefit in a high‑risk group (associational).

PubMed ID: 18544622

Direct vitamin D3 supplementation in elderly hip‑fracture patients reliably increased serum 25(OH)D across dosing regimens—mechanistic support for bone health.

PubMed ID: 23809140

Prospective study in ART-treated HIV patients showed vitamin D insufficiency and concurrent lumbar spine BMD loss over 21 months (observational link of low vitamin D status to bone loss).

PubMed ID: 25480348

Alfacalcidol (D-hormone analog) added to strontium ranelate significantly improved lumbar spine BMD and reduced bone resorption—strong clinical bone benefit from active vitamin D therapy.

PubMed ID: 29151102

In postmenopausal women, raising vitamin D (on calcium background) was associated with lower PTH and reduced bone‑turnover markers — strong human bone‑health signal.

PubMed ID: 24139824

Fortified juice in children increased 25(OH)D significantly—adequate vitamin D in childhood supports bone mineralization and strength.

PubMed ID: 26481332

Oily fish / fish‑oil supplementation in deficient schoolchildren raised 25OHD and affected PTH/ALP—supports skeletal vitamin D effects in growing children.

PubMed ID: 29500675

Post-gastric‑bypass investigational multivitamin raised vitamin D and lowered PTH—biochemical pattern consistent with improved calcium balance and bone health.

PubMed ID: 38051700

Large preconception/pregnancy supplementation trial (10 µg/day vitamin D included) markedly reduced maternal deficiency—important for fetal skeletal development and maternal bone health.

PubMed ID: 38411017

Preconception/pregnancy supplementation raised milk 25(OH)D by ~20%—improves infant vitamin D exposure with implications for bone mineralization.

PubMed ID: 12791627

Fortified beverages (1000 IU/day) markedly raised serum 25(OH)D and lowered PTH—directly relevant to bone health.

PubMed ID: 24267005

Large school‑based RCT in children: supplement increased 25(OH)D most and bone biomarkers were similar for supplement and fortified milk—supports bone effects.

PubMed ID: 15658548

Multinutrient supplement (including vitamin D 200 IU) modestly increased spine and hip BMD vs observation or calcium alone.

PubMed ID: 31338563

13‑week RCT in older adults: vitamin D‑containing supplement raised 25(OH)D, lowered PTH and produced small but significant increases in total‑body BMD.

PubMed ID: 2387950

Daily vitD+calcium raised circulating 25(OH)D in elderly women—supportive for bone health though calcium confounds attribution.

PubMed ID: 2221645

Calcitriol (active vitD) RCT in osteoporotic postmenopausal women increased spine BMD and total body calcium over 2 years.

PubMed ID: 2325572

Low‑dose calcitriol preserved spinal height in postmenopausal osteoporosis versus calcium; clinically relevant bone outcome with active vitamin D.

PubMed ID: 1883119

Randomized trial: modest daily vitamin D (~500 IU) reduced late‑winter bone loss and produced a small net spine BMD gain over 1 year.

PubMed ID: 1823383

Calcitriol raised serum and urinary calcium and lowered PTH as expected—physiologic changes relevant to bone health.

PubMed ID: 1729617

Large randomized trial: oral calcitriol dramatically reduced new vertebral and some peripheral fractures versus calcium—strong direct bone benefit.

PubMed ID: 7684512

Calcitriol (with/without calcitonin) significantly prevented lumbar spine bone loss versus calcium alone—robust bone benefit.

PubMed ID: 8461542

Randomized trial: calcitriol + calcium largely prevented lumbar spine bone loss over 12 months in steroid users—strong direct bone‑protective evidence.

PubMed ID: 8131343

(duplicate entry already high-scored for BMC prevention; included once with strong support).

PubMed ID: 7974045

800 IU/day in very‑low‑birth‑weight infants associated with low overt rickets rates—prevention of bone disease in neonates.

PubMed ID: 8172088

Single 100,000 IU increased 25(OH)D by ~60% and modestly lowered PTH—biochemical changes linked to bone health.

PubMed ID: 8074071

High intermittent doses markedly raised 25(OH)D (and in high doses caused hypercalcemia) —strong pharmacologic effect on vitamin D status relevant to bone.

PubMed ID: 8003844

Both groups (with vitamin D) increased lumbar spine BMD over 2 years—vitamin D was background but bone endpoints improved.

PubMed ID: 8049820

In steroid‑treated asthmatics, regimen including vitamin D increased lumbar spine BMD and prevented new vertebral fractures over 6 months.

PubMed ID: 8062152

Double‑blind RCT: 1α‑OH‑vitamin D increased spine BMD and substantially reduced vertebral fractures—direct strong evidence.

PubMed ID: 17974384

Adding 24,25(OH)2D3 produced favorable biochemical changes including PTH and vitamin D metabolites in dialysis patients—supports bone metabolism.

PubMed ID: 7606425

In vitamin D–deficient institutionalized elderly, vitamin D3 with calcium substantially raised 25-OH-D and halved elevated PTH—biochemical bone benefits.

PubMed ID: 7699532

In pubertal girls, increased dairy (including vitamin D) produced markedly larger gains in spine and total body bone mineral; effect is multi-nutrient but bone-relevant.

PubMed ID: 8808216

Low-dose calcitriol prevented rise in PTH in moderate renal failure without changing serum calcium—beneficial for bone metabolism.

PubMed ID: 7714065

Large RCT: daily 400 IU vitamin D3 raised 25-OH-D, lowered PTH slightly and produced a small but significant femoral neck BMD increase over 2 years.

PubMed ID: 7677827

Alfacalcidol (active vitamin D) in renal failure produced marked histological resolution of renal bone disease vs placebo—strong bone evidence.

PubMed ID: 7733040

Duplicate entry (higher dose vitamin D reduced femoral neck loss)—key randomized bone result.

PubMed ID: 7781871

Combination of ipriflavone + 1alpha vitamin D largely prevented vertebral bone loss versus single agents or control.

PubMed ID: 8967706

Randomized double‑blind: Ca + D3 prevented steroid‑associated spine and trochanter bone loss in RA patients.

PubMed ID: 8906139

Preterm infants receiving higher‑vitamin‑D fortifier had improved calcium and alkaline phosphatase — supports bone mineral status.

PubMed ID: 9026268

2‑year RCT of 1α‑OH vitamin D3 increased lumbar spine BMD and was associated with fewer fractures vs placebo.

PubMed ID: 8633378

Alphacalcidol after heart transplant reduced early bone loss and osteoporotic complications vs comparator.

PubMed ID: 9278463

Large RCT: Ca + 700 IU D3 modestly increased/preserved BMD and reduced nonvertebral fractures in older adults.

PubMed ID: 9258754

Vitamin D 400 IU/day increased femoral neck BMD significantly in elderly women with certain VDR genotypes.

PubMed ID: 9099188

1α‑hydroxyvitamin D plus calcium in stroke patients preserved/increased BMD and prevented hip fractures (clear clinical bone benefit).

PubMed ID: 9388377

Alfacalcidol increased lumbar spine and distal radius BMD and reduced vertebral fractures in elderly osteoporotic patients.

PubMed ID: 9797910

Repeated entry (same strong evidence as above).

PubMed ID: 9568825

Intermittent 1α-hydroxyvitamin D2 markedly suppressed PTH in dialysis patients—direct effect on parathyroid-mediated bone turnover.

PubMed ID: 9737353

Calcitriol increased bone-formation markers and lowered PTH in healthy men—direct biochemical evidence supporting bone effects.

PubMed ID: 9504953

Fortified milk doubled low 25OHD in elderly over one year—relevant to correcting deficiency that affects bone.

PubMed ID: 9697664

IV paricalcitol in dialysis caused large, clinically meaningful iPTH and alkaline phosphatase reductions—strong support for vitamin D analogue effects on bone turnover.

PubMed ID: 9797906

Well-powered dose–response study quantifying how oral D3 raises 25(OH)D—foundational evidence linking supplementation dose to a bone-relevant biomarker.

PubMed ID: 9734615

Intraperitoneal calcitriol produced very large PTH suppression vs oral in children on dialysis—strong bone-relevant biochemical effect.

PubMed ID: 9405729

Vitamin D3 pills raised 25OHD in controlled trial—supports capacity of supplementation to affect bone-relevant metabolite.

PubMed ID: 9771208

Randomized trial: adding calcitriol to etidronate produced clear additional spine and hip BMD gains—strong direct evidence for active vitamin D improving BMD.

PubMed ID: 10367032

Alfacalcidol prevented corticosteroid‑induced lumbar spine bone loss vs placebo (significant BMD preservation).

PubMed ID: 9951784

Calcitriol + calcium added to bisphosphonate therapy prevented forearm bone loss and blunted PTH rise (clear appendicular bone benefit).

PubMed ID: 10599715

Infant vitamin D supplementation associated with higher hip and wrist BMD years later — strong observational/controlled evidence for durable bone benefit.

PubMed ID: 11180916

Randomized trial: vitamin D3 (and D3+K2) increased lumbar spine BMD vs calcium — direct, high-quality evidence for bone benefit.

PubMed ID: 10966893

Stopping calcium + vitamin D led to loss of prior BMD gains over 2 years in older adults — supports role of supplementation in maintaining bone.

PubMed ID: 11193249

Calcitriol produced modest (~2%) spine BMD gains over 12 months — modest direct bone benefit.

PubMed ID: 10769437

Alfacalcidol prevented steroid-related bone loss and improved formation markers over 3 years — direct protective bone effect.

PubMed ID: 10929446

Alfacalcidol + calcium increased spine BMD over 3 years vs plain vitamin D + calcium — active analog showed superior bone effects.

PubMed ID: 10977001

Calcitriol after heart/lung transplant reduced proximal femur bone loss — trial-level evidence of bone protection (with hypercalciuria risk).

PubMed ID: 10620210

IV calcitriol strongly suppressed bone turnover markers in dialysis patients (clinically meaningful).

PubMed ID: 10914864

Calcitriol produced a small spine BMD increase in steroid-treated premenopausal women (modest effect).

PubMed ID: 11045316

Intraperitoneal calcitriol was more effective than oral pulse for PTH suppression and osteodystrophy resolution.

PubMed ID: 11146310

Dividing weekly calcitriol dose produced greater PTH suppression—supports bone-protective mechanism.

PubMed ID: 11697808

Alendronate + calcitriol increased BMD post-kidney transplant; calcitriol contributed to bone improvements.

PubMed ID: 11531934

Alfacalcidol (vitamin D analog) + HRT produced a substantial, significant spine BMD increase over 2 years.

PubMed ID: 11502787

Calcitriol alone produced a modest spine BMD gain and added modestly to hormone therapy; direct evidence of bone effect (though modest).

PubMed ID: 11277275

Calcitriol given after heart/lung transplant partially reduced early bone loss versus no treatment (short-term protection).

PubMed ID: 11991447

Large RCT: Ca+vitamin D prevented hip bone loss (femoral neck BMD change difference ≈2.65%/yr) and normalized PTH in elderly women.

PubMed ID: 12027147

In vitamin D–deficient postmenopausal women, adding vitamin D to calcium lowered PTH and raised 25(OH)D — favorable bone‑related biochemical changes.

PubMed ID: 11966500

Calcium + vitamin D increased lumbar spine BMD in IBD patients; vitamin D was part of the effective regimen though not isolated.

PubMed ID: 12414850

Calcitriol (active D) and estrogen increased BMD; study directly shows vitamin D (active form) contributes to bone density gains.

PubMed ID: 11889427

Randomized double‑blind calcitriol vs placebo after heart transplant produced large, significant increases in lumbar spine BMD and reduced resorption markers.

PubMed ID: 12039990

Active vitamin D + calcium after kidney transplant significantly reduced early spine and femur bone loss.

PubMed ID: 12521277

Randomized trial in infants with rickets showed vitamin D (±calcium) corrected biochemical rickets and radiographic healing — direct bone benefit.

PubMed ID: 11961400

Dose‑response IV calcitriol in dialysis clearly suppressed PTH (bone turnover driver) — supports bone health.

PubMed ID: 12184546

Active vitamin D started after gastrectomy improved calcium/PTH and bone markers consistent with bone-protection.

PubMed ID: 14506952

Randomized trial: adding calcitriol to HRT yielded additional, site-specific BMD gains—direct active vitamin D bone benefit.

PubMed ID: 15040824

Large program of daily calcium + 400 IU vitamin D reduced osteoporotic fractures (~16%) in older community residents.

PubMed ID: 14657693

Calcitriol increased spine and hip BMD in renal transplant patients (direct active vitamin D effect).

PubMed ID: 14602746

In elderly women with low vitamin D, calcium + vitamin D raised BMD, normalized 25‑OHD and decreased bone resorption markers.

PubMed ID: 12913194

Third listing for the sunlight study (key strong bone evidence).

PubMed ID: 20299186

Exercise plus milk containing vitamin D produced larger femoral-neck BMD increases in boys with intellectual disability — vitamin D part of fortified milk.

PubMed ID: 20370938

Long (30-month) fortified-dairy intervention delivering ~22.5 μg/d vitamin D + calcium produced significant BMD gains in postmenopausal women.

PubMed ID: 21147706

High‑dose intermittent vitamin D raised 25(OH)D and improved bone measures in girls ≤2 years post-menarche (subgroup benefit).

PubMed ID: 20662329

Preschoolers given cereal with calcium and vitamin D3 had ~5% spine BMD increase vs control over nine months (direct skeletal benefit).

PubMed ID: 20964867

Ibandronate + alfacalcidol preserved cortical bone and increased spine BMD in glucocorticoid-treated SLE patients; vitamin D analogue was part of therapy.

PubMed ID: 20593151

Infant bolus dosing reliably normalized vitamin D status, which is strongly linked to rickets prevention and early-life bone health.

PubMed ID: 21029610

Alfacalcidol included in combination osteoporosis regimens that improved lumbar spine and femur BMD over 48 weeks.

PubMed ID: 20308769

Schoolgirls receiving monthly/two-monthly 60,000 IU D3 had substantive increases in 25(OH)D; improving status in growing girls supports bone accrual.

PubMed ID: 20427425

High‑dose IM vitamin D in severely deficient adolescents normalized labs and produced radiographic bone healing and symptom improvement.

PubMed ID: 21245882

Randomized feeding trial in underprivileged toddlers: monthly 30,000 IU vitamin D + calcium produced substantially greater whole‑body BMC accrual.

PubMed ID: 21253392

Crohn’s patients receiving calcium + cholecalciferol showed increased lumbar spine BMD over long-term follow-up.

PubMed ID: 21672334

Combination alendronate + alfacalcidol improved BMD vs alfacalcidol alone (vitamin D analog present in all groups); supports bone outcomes in regimens including vitamin D.

PubMed ID: 21253715

Large RCT showed calcium + 400 IU vitamin D produced small but significant preservation of hip BMD and local hip geometry benefits.

PubMed ID: 21725510

Both arms given colecalciferol + calcium showed significant increases in lumbar spine T-score over years (bone benefit as part of baseline therapy).

PubMed ID: 21555774

Baseline vitamin D deficiency associated with poorer periodontal outcomes and lower BMD responses in context of oral surgery — strong association with bone/periodontal repair.

PubMed ID: 22130786

Alfacalcidol added to raloxifene blunted PTH rise and produced substantially greater lumbar spine BMD gains over 2 years — strong bone outcome.

PubMed ID: 21364273

Alfacalcidol (active vitamin D) added to alendronate produced significant additional increases in lumbar spine BMD and tibial bone strength vs alendronate alone.

PubMed ID: 21784190

Active vitamin D analog RCT significantly reduced vertebral fractures and increased BMD — strong direct bone-strength evidence.

PubMed ID: 23208074

WHI Ca+D trial showed suggestive long-term hip-fracture reduction in non-users — moderate population-level bone benefit signal.

PubMed ID: 23064476

Alendronate + calcitriol prevented AI-induced lumbar bone loss over 24 weeks — calcitriol (active D) contributed to bone preservation (combined therapy).

PubMed ID: 23104564

Rickets trial: combined vitamin D + calcium produced markedly better radiological healing — strong bone outcome in children.

PubMed ID: 22644348

Fortified milk RCT raised 25(OH)D, lowered PTH and reduced bone turnover markers in postmenopausal women — supports bone health.

PubMed ID: 22431675

Dose–response RCT in postmenopausal women showing reliable repletion and PTH change—supports bone health recommendations.

PubMed ID: 22357739

Postmenopausal fortified cheese reduced TRAP5b and raised IGF‑I over 6 weeks—favorable bone turnover marker changes.

PubMed ID: 22551881

Large RCT in elderly women: 800 IU D3 + calcium raised 25(OH)D and slowed distal radius BMD loss—strong clinical bone outcome.

PubMed ID: 22933541

Infant RCT: dose‑dependent increases in 25(OH)D and trends to larger tibial bone size—direct skeletal benefit in infants.

PubMed ID: 22503722

School‑based calcium program that included vitamin D improved bone mass accrual in girls (vitamin D was part of the regimen; likely supportive).

PubMed ID: 23653431

Vitamin D‑ and calcium‑fortified yogurt in very old women substantially raised 25(OH)D, lowered PTH and bone resorption (TRAP5b)—strong physiological evidence for bone benefit.

PubMed ID: 24429202

Calcifediol plus calcium increased spine bone density in some young cystic fibrosis patients—direct vitamin D metabolite effect on bone.

PubMed ID: 23364004

Randomized trial in vitamin D‑insufficient postmenopausal women showed vitamin D supplementation increased true fractional calcium absorption—mechanistic basis for stronger bones.

PubMed ID: 23719547

Prenatal calcium plus low‑dose vitamin D in adolescents increased maternal lumbar spine bone mass postpartum—direct maternal bone benefit.

PubMed ID: 23199009

Calcitriol plus cholecalciferol lowered bone turnover markers (P1NP, CTx) indicating a shift toward bone formation in HIV‑infected men.

PubMed ID: 24335055

Dose‑ranging RCT showed higher vitamin D doses linearly increased intestinal calcium absorption—mechanism directly supportive of bone health.

PubMed ID: 23183751

One‑year vitamin D supplementation in older adults raised 25(OH)D and reduced PTH and multiple bone turnover markers—strong bone‑relevant biochemical evidence.

PubMed ID: 23591713

Randomized study in vitamin D‑deficient obese adults: large 25(OH)D rises, reduced PTH and a small but significant forearm BMD increase.

PubMed ID: 23902955

Higher vitamin D intake in preterm infant formula raised 25(OH)D and increased bone mineral accrual by 6 months corrected age.

PubMed ID: 23652464

Multifactorial program halved hip fracture incidence and increased vitamin D/calcium use—vitamin D likely contributed to bone protection.

PubMed ID: 23378417

Biweekly cholecalciferol in haemodialysis raised 25(OH)D and significantly reduced PTH, a bone‑protective effect in CKD context.

PubMed ID: 23595003

Different dosing regimens changed serum 25‑OH‑D and hypercalciuria risk—relevant to achieving bone‑protective status and safety.

PubMed ID: 23460234

Vitamin D–fortified milk raised 25(OH)D and reduced deficiency in children—supports bone health via status correction.

PubMed ID: 23564348

Single IM 600,000 IU produced sustained sufficiency at 6 months—supports ability to restore status for bone health.

PubMed ID: 23585346

RCT: 1000 IU/day D3 prevented hip bone loss vs lower doses/placebo—strong bone benefit.

PubMed ID: 23810841

Adolescent RCT: vitamin D supplementation improved aBMD and hip structural geometry in girls.

PubMed ID: 24748637

Rickets trial: adding vitamin D to calcium hastened radiographic/biochemical healing and increased 25(OH)D.

PubMed ID: 24423366

Pre-op treatment in primary hyperparathyroidism raised 25OHD, lowered PTH and increased lumbar spine BMD.

PubMed ID: 24414607

Pediatric RCT: vitamin D+calcium prevented steroid-induced lumbar spine BMC loss with large clinically important effect.

PubMed ID: 25118085

Calcium+vitamin D during basic military training prevented PTH rise and improved tibial vBMD/cortical measures.

PubMed ID: 24401754

High‑dose vitamin D regimens produced biochemical and radiographic healing of nutritional rickets in children — strong direct bone benefit.

PubMed ID: 24488080

Two‑year Ca+D changed bone biomarkers (lower PTH/osteocalcin, sclerostin increase in men) consistent with reduced bone turnover and bone preservation.

PubMed ID: 24426779

Alfacalcidol (active vitamin D analog) increased lumbar spine and trochanter BMD and lowered bone turnover over 12 months.

PubMed ID: 23799356

Large randomized trial showed Ca+D enhanced hip‑fracture protection with hormone therapy — substantial population bone benefit when combined.

PubMed ID: 25524023

Alendronate + cholecalciferol increased BMD and reduced turnover versus cholecalciferol alone in normocalcemic primary HPT — vitamin D part of effective regimen.

PubMed ID: 24856872

Weekly 25,000 IU cholecalciferol in hemodialysis patients raised 25(OH)D and 1,25(OH)2D and improved calcium target attainment—supporting bone mineral maintenance.

PubMed ID: 25166750

Daily 3000 IU vitamin D3 substantially increased 25(OH)D and 1,25(OH)2D, biochemical changes consistent with bone-supporting effects.

PubMed ID: 25005834

2,000 IU/day in submariners produced the largest 25(OH)D rise and increased osteocalcin (bone formation marker) over 3 months.

PubMed ID: 24714660

In pregnancy, ≥2,000 IU/day was required to produce maternal/infant 25OHD sufficiency—a key determinant of fetal/neonatal bone development.

PubMed ID: 25363733

Both IV active VDR agonists lowered iPTH in dialysis patients, directly affecting mineral/bone metabolism.

PubMed ID: 24131674

Paricalcitol dosing in dialysis patients produced robust iPTH suppression while maintaining Ca/P, affecting bone turnover and strength.

PubMed ID: 23857798

Large cohort shows inverse relationship between 25OHD and PTH, underpinning vitamin D’s role in bone/mineral homeostasis.

PubMed ID: 25325204

RCT in preterm infants showed 200 IU/day vitamin D sufficient to prevent osteopenia, direct bone-protective evidence.

PubMed ID: 24322182

Adding 1000 IU D3 to osteoporosis therapy rapidly corrected insufficiency (biochemical correction relevant to bone outcomes).

PubMed ID: 25923487

Older women consuming vitamin D+calcium–fortified yogurt had increased 25(OH)D, decreased PTH and lower bone resorption markers.

PubMed ID: 26264387

Fortified milk raised 25(OH)D and reduced bone resorption markers (CTx‑1, PINP), supporting bone-preserving effects.

PubMed ID: 26075752

Randomized trial in ART‑naïve HIV patients: vitamin D3 (4000 IU) + calcium halved ART‑associated bone loss and attenuated bone turnover—strong direct bone benefit.

PubMed ID: 25626413

Daily milk powder with calcium + vitamin D reduced lumbar spine bone loss in postmenopausal women—direct BMD benefit (combined intervention).

PubMed ID: 26675772

Dietary vitamin D at EAR/RDA in children raised 25(OH)D and the proportion achieving ≥50 nmol/L (supports bone-health substrate in growth).

PubMed ID: 25592133

Active vitamin D analog (eldecalcitol) added to alendronate increased spine and hip BMD vs alendronate + plain vitamin D/calcium—supports vitamin D pathway benefit to bone.

PubMed ID: 26350034

Multi-component post-bariatric program including vitamin D attenuated bone turnover rises and slowed aBMD loss.

PubMed ID: 26465394

Cross-sectional study found 25OHD thresholds below which higher levels were associated with greater total-body BMD in adolescents.

PubMed ID: 26396095

Calcitriol (active vitamin D) prevented bone loss and increased lumbar spine BMD versus calcium alone in glucocorticoid-treated patients.

PubMed ID: 26024678

Pediatric burn follow-up: fractures occurred in placebo/D2 groups but none in D3 group, suggesting fracture risk reduction.

PubMed ID: 25656524

Single large 25‑OH vitamin D dose in dialysis patients raised 25(OH)D and transiently suppressed PTH—biologic effects important to bone/mineral homeostasis.

PubMed ID: 25899914

Individualized loading normalized 25(OH)D rapidly in nursing-home patients—raising vitamin D status supports bone health and fracture prevention strategies.

PubMed ID: 27325795

VLBW preterm infants: 1000 IU/day vs 400 IU raised 25(OH)D, Ca and lowered PTH/ALP with less hypomineralization — strong randomized bone outcome evidence.

PubMed ID: 27401037

CKD stage 3–5: ergocalciferol raised 25(OH)D more than calcitriol though ultimate bone‑mineral targets were similar — relevant to bone‑mineral status.

PubMed ID: 27542236

Randomized 12‑week trial: vitamin D–enriched salmon or tablets raised 25(OH)D and reduced bone resorption markers — direct bone benefit.

PubMed ID: 26782853

Elderly nursing‑home dosing produced dose‑dependent rises in total/free 25(OH)D with no safety issues — supports bone health in very old adults.

PubMed ID: 27880946

DP001 (vitamin D analog) in dialysis sharply lowered PTH — clinically relevant to bone/CKD‑mineral disease.

PubMed ID: 27986983

Large older‑adult dose trial produced dose‑dependent 25(OH)D increases and reduced PTH — supports bone health via improved status and PTH suppression.

PubMed ID: 27149055

Preterm infant RCT: 1,000 vs 400 IU/day drastically reduced vitamin D insufficiency at term — strong implication for neonatal bone health and mineralization.

PubMed ID: 26841085

Adolescent girls retained greater hip BMC one year after stopping supplementation — persistent bone mass benefit in females.

PubMed ID: 26864127

Small RCT showed D3 supplements raised total 25(OH)D more effectively than D2 from bread — relevant to choosing forms for bone health.

PubMed ID: 27676085

ER calcifediol normalized 25(OH)D in CKD and progressively lowered iPTH — supports bone‑mineral benefits in CKD.

PubMed ID: 26852398

In gastric‑bypass patients, a single high IM cholecalciferol dose produced sustained 25(OH)D increases — important for skeletal health when malabsorption present.

PubMed ID: 26196201

Weekly weight‑based high vitamin D3 in children with IBD safely and effectively raised 25(OH)D — relevant to pediatric bone health.

PubMed ID: 28975432

One-year randomized fortified-milk trial raised 25(OH)D, suppressed bone turnover markers and tended to preserve femoral neck BMD — direct bone benefit.

PubMed ID: 28148500

Large Ca+D RCT demonstrated substantial fracture risk reduction in the lowest genetic BMD‑risk quartile—strong bone outcome evidence.

PubMed ID: 29027817

Maternal high‑dose postpartum vitamin D raised infant 25(OH)D and eliminated biochemical rickets—clear bone health benefit for infants.

PubMed ID: 29273827

Active vitamin D analogues robustly increased fractional intestinal calcium absorption—mechanistic support for bone mineralization.

PubMed ID: 28921338

Five‑year D3 trial reduced femoral‑neck bone loss in men with prediabetes (site‑specific BMD benefit).

PubMed ID: 28647736

Large infant cohort showed safety of daily D3 at common doses and achieved typical 25(OH)D levels — supports safe bone-targeted supplementation in infants.

PubMed ID: 28832406

Well-powered RCT in ART patients: vitamin D+calcium markedly increased 25(OH)D, blunted PTH rise, and helped prevent ART-related BMD loss — strong bone outcome support.

PubMed ID: 27768857

Large RCT (2000 IU/day) substantially raised 25(OH)D and lowered PTH — biochemical effects consistent with bone health support.

PubMed ID: 29178404

Rickets (vitamin D deficiency) tied to poor outcomes; treated rickets associated with improved linear growth — direct pediatric bone disease relevance.

PubMed ID: 29247782

Daily 1000 IU with calcium in children raised 25(OH)D and achieved sufficiency in many — supports skeletal development/maintenance in children.

PubMed ID: 28332096

Paricalcitol (vitamin D receptor agonist) in pediatric CKD reduced iPTH—a mechanism-important effect for bone/mineral health in secondary hyperparathyroidism.

PubMed ID: 28429905

Maintenance dosing reliably raised 25(OH)D in postmenopausal women (biomarker important for bone health), supporting bone-related adequacy.

PubMed ID: 28466679

Randomized pediatric trial: 1000 IU/day vitamin D increased 25(OH)D and produced a modest but significant increase in bone mineral content vs 400 IU/day.

PubMed ID: 29676968

Large 2‑year randomized trial: vitamin D/calcium–fortified milk increased femoral neck BMD and raised 25(OH)D—strong direct bone-health evidence.

PubMed ID: 29970059

Native vitamin D added to alendronate improved 25(OH)D status and had acceptable calcium safety in osteoporotic women—supports bone therapy co‑management.

PubMed ID: 29040219

Postmenopausal women receiving calcium+vitamin D plus high‑impact exercise had significant femoral‑neck BMD improvements.

PubMed ID: 30075569

Combination therapy analyses show vitamin D given with antiresorptive therapy associated with spine BMD gains (but attribution to vitamin D alone limited).

PubMed ID: 30532527

Calcitriol lowered PTH and sclerostin (bone metabolism markers) and increased muscle strength in postmenopausal women—favors bone health.

PubMed ID: 29450585

1000 IU/day increased 25(OH)D and reduced bone turnover markers, consistent with bone‑protective effects.

PubMed ID: 29156056

High‑dose cholecalciferol in CKD raised 25(OH)D and 1,25(OH)2D and attenuated secondary hyperparathyroidism—beneficial for mineral/bone health in CKD.

PubMed ID: 29665087

RCT reanalysis: vitamin D increased spine and hip BMD in adults with baseline 25OHD ≤30 nmol/L — strong, subgroup‑specific bone benefit.

PubMed ID: 29851760

Winter supplementation raised 25(OH)D and produced a femoral‑neck BMC increase in dark‑skinned children (subgroup benefit).

PubMed ID: 30092157

In steroid‑treated children vitamin D prevented bone loss over 12 months — clear protective effect on bone.

PubMed ID: 30587642

Dose‑dependent increases in 25(OH)D and consistent changes in bone turnover markers in schoolgirls indicate meaningful bone effects.

PubMed ID: 30902791

Calcium+vitamin D in Marine recruits increased 25(OH)D, decreased bone turnover markers and produced modest improvements in bone strength indices (season-dependent).

PubMed ID: 31087185

Eldecalcitol (vitamin D analogue) produced statistically significant BMD increases in osteoporotic patients—direct bone-strength evidence.

PubMed ID: 30843501

Large pediatric RCT: daily 2000 IU effectively raised 25(OH)D and reduced secondary hyperparathyroidism—strong bone-health biomarker effects.

PubMed ID: 31136042

Large pediatric trial: both daily and single high-dose vitamin D restored sufficiency safely—restoring 25OHD is a necessary step for bone health in deficient children.

PubMed ID: 32588047

Fortified milk (including vitamin D) raised 25(OH)D and reduced bone turnover markers—direct evidence of favorable bone-related biochemical changes.

PubMed ID: 32495521

Study in very old with osteopenia showed improved BMD and fewer fragility fractures in the active treatment arm (active vitamin D present), supporting bone effects in this population.

PubMed ID: 32671481

Vitamin D+calcium raised 25(OH)D to sufficiency and denosumab produced BMD increases and fewer vertebral fractures across baseline statuses.

PubMed ID: 32722015

Fortified milk (vitamin D plus other bone nutrients) preserved/increased bone mass and improved bone turnover markers in menopausal women.

PubMed ID: 33040465

Randomized trial in youth on PrEP: vitamin D plus calcium produced greater lumbar spine BMD increase over 6 months.

PubMed ID: 32346686

Higher baseline vitamin D and supplementation meaningfully improved bone turnover marker responses and short‑term BMD gains with zoledronate in osteoporotic postmenopausal women.

PubMed ID: 34980546

Adding collagen peptides to calcium+vitamin D improved tibial trabecular vBMD and prevented spine BMD loss vs Ca+D alone—vitamin D part of effective regimen.

PubMed ID: 34125899

High‑dose vitamin D plus calcium increased spine BMD z‑score in adolescents with perinatally acquired HIV.

PubMed ID: 33427961

Dose‑dependent correction of deficiency in overweight/obese children—repletion supports skeletal health long term.

PubMed ID: 34861430

Calcium plus vitamin D prevented rises in bone resorption markers during intensive training—biochemical bone protection.

PubMed ID: 34747516

Kidney transplant RCT: 4000 IU cholecalciferol raised 25(OH)D, lowered PTH and prevented small spine BMD loss—direct skeletal benefit.

PubMed ID: 33280041

Dose‑dependent vitamin D increases in older adults correlated modestly with lower PTH and some site‑specific BMD changes—supports bone effects.

PubMed ID: 34470599

Infant RCT: 400 IU/day markedly increased infant 25(OH)D and prevented deficiency—important for infant bone development and prevention of rickets.

PubMed ID: 34302325

Fortified milk (low‑dose D2) raised 25OHD modestly and markedly reduced secondary hyperparathyroidism in children — bone‑related benefit although sufficiency not achieved.

PubMed ID: 33888407

Supervised sun exposure increased 25(OH)D in institutionalized elderly — clinically meaningful repletion relevant to bone health.

PubMed ID: 34371803

Randomized pharmacodynamic study in deficient adults showed clear endocrine/bone‑marker responses to cholecalciferol (↑1,25(OH)2D, ↓PTH) — strong mechanistic support for bone effects.

PubMed ID: 35763213

Daily 600 IU vitamin D prevented valproate-associated decline in vitamin D and adverse changes in calcium/bone markers in children, preserving bone‑relevant physiology.

PubMed ID: 34936992

Education increased vitamin D supplement use and was associated with higher hip/L1 BMD and fewer fragility fractures over five years.

PubMed ID: 35088103

In XLH children higher-dose calcitriol produced significantly greater rickets improvement and better bone-related biochemical markers over 24 months.

PubMed ID: 37111231

Daily fortified milk (calcium + vitamin D) for a year increased bone mineral accrual in preschool children (direct bone benefit with D as component).

PubMed ID: 36833994

Children with fractures: low 25OHD linked to higher fracture risk and supplementation improved vitamin D levels and callus formation.

PubMed ID: 38613445

Daily 2000 IU produced a small but measurable hip BMD gain over 3 years in older adults.

PubMed ID: 38325238

Type‑1 diabetes youth: vitamin D with milk/calcium improved BMC/BMD and cortical geometry over 1 year (robust bone benefit).

PubMed ID: 38520382

High‑dose weekly 50k IU in men on ADT markedly raised 25OHD and reduced total hip BMD loss over 24 weeks.

PubMed ID: 38584410

Maternal supplementation in 3rd trimester raised infant and cord 25(OH)D and prevented severe deficiency in breastfed infants—important for neonatal bone mineralization risk.

PubMed ID: 40259289

HIIT plus daily vitamin D produced significant increases in 25‑OH‑D, BMD, and favorable bone turnover marker changes in osteoporotic women.

PubMed ID: 20487100

Animal (broiler) study: higher dietary vitamin D3 improved growth and bone mineral content — supportive but species‑limited evidence.

PubMed ID: 40042722

Zoledronic acid added to calcium+calcitriol (active vitamin D) improved BMD and bone markers vs calcium+calcitriol alone—shows active vitamin D contributes in combined therapy.

PubMed ID: 40499784

Dose‑finding RCT in overweight/obese children: 4,000–6,000 IU/day safely and reliably restored 25(OH)D—supports repletion important for bone health in youth.

PubMed ID: 40963202

High single-dose vitamin D before ultramarathon produced rapid rises in 25(OH)D and favorable bone turnover shifts (↓CTX, ↑PINP).

PubMed ID: 40806109

Daily 4000 IU vitamin D + calcium in children with ALL raised 25(OH)D, lowered PTH and reduced a bone resorption marker (ICTP).

PubMed ID: 40507157

800 IU/day in preterm infants substantially increased 25(OH)D and markedly reduced vitamin D insufficiency prevalence vs 400 IU/day.

PubMed ID: 41387706

Toddler formula with added vitamin D increased 25(OH)D and produced modest improvements in bone quality (tibia SOS).

PubMed ID: 39812183

Eldecalcitol (active vitamin D analog) added to risedronate produced significant lumbar spine BMD increases over 24 months.

PubMed ID: 40466630

Extended-release calcifediol in dialysis patients greatly raised 25D/1,25D and stabilized iPTH—biomarkers linked to bone health.

PubMed ID: 11886767

Combination vitamin K2+vitamin D3 increased vertebral BMD vs K2 alone — direct evidence vitamin D3 contributed to BMD gain (combo trial).

PubMed ID: 12898306

Etidronate + alfacalcidol (vitamin D analog) produced greater lumbar spine BMD gain vs etidronate alone — strong direct support for active vitamin D effect on bone.

PubMed ID: 21776573

After hip replacement, alfacalcidol prevented lumbar spine bone loss though not periprosthetic loss — shows active vitamin D preserved spine BMD post‑op.

PubMed ID: 22126423

In children with CP/osteoporosis, vitamin D plus bisphosphonate improved BMD over ≥1 year vs vitamin D alone or stopping—direct skeletal benefit in combination therapy.

PubMed ID: 23043189

Adding vitamin D to alendronate raised 25(OH)D and produced a modest additional fall in bone resorption markers in vitamin D–deficient patients.

PubMed ID: 23771807

16‑week RCT of iron+vitamin D‑fortified milk increased 25OHD and reduced bone turnover markers—controlled evidence of vitamin D's skeletal biomarker effect.

PubMed ID: 23761968

Monthly 30,000 IU cholecalciferol normalized 25(OH)D and reduced PTH in osteoporotic patients—supports bone health via correcting deficiency.

PubMed ID: 29044707

High‑dose cholecalciferol in CKD raised 25(OH)D and lowered PTH and bone turnover markers—strong biochemical evidence for skeletal effect.

PubMed ID: 30007343

Diet + low‑dose vitamin D raised 25(OH)D and slowed hip bone loss in those with baseline osteoporosis—site‑specific skeletal benefit.

PubMed ID: 32131365

Maternal vitamin D supplementation produced a significantly greater offspring bone‑formation response after mechanical loading — strong RCT surrogate for bone strength development.

PubMed ID: 34297067

Well‑powered pregnancy RCT showed cholecalciferol attenuated pregnancy rise in bone‑resorption marker and link between resorption and lower postpartum BMD.

PubMed ID: 36216304

Calcitriol in T2DM with CKD reduced PTH and bone turnover markers over 48 weeks — meaningful biochemical bone remodeling effects.

PubMed ID: 8052367

In dialysis patients, calcitriol (active vitamin D) produced large and clinically meaningful PTH suppression, directly relevant to bone/mineral metabolism (strong evidence in CKD context).

PubMed ID: 22300739

Weekly high‑dose ergocalciferol raised 25(OH)D and 1,25(OH)2D and increased FGF23 and urinary phosphate excretion—clear effects on mineral homeostasis relevant to bone health.

PubMed ID: 18043700

Multivitamin including vitamin D significantly increased serum 25(OH)D and improved heel quantitative ultrasound, indicating better bone quality in aged‑care residents.

PubMed ID: 32844185

Maternal multiple‑micronutrient supplement (including vitamin D) increased cord 25(OH)D — plausible neonatal bone benefit via improved fetal vitamin D status.

PubMed ID: 16088114

Vitamin D (1,000 IU/day) in women after stroke cut falls ~59% and hip fractures were absent in treated vs placebo—strong clinical bone/fracture benefit signal.

PubMed ID: 21832027

Fortified milk RCT in toddlers markedly raised 25(OH)D and reduced deficiency—directly supports bone health in children via vitamin D repletion.

PubMed ID: 24317556

Fortified‑milk increased 25OHD in young women; raising 25OHD supports bone mineral metabolism although direct bone outcomes not measured.

PubMed ID: 25012612

Injected vitamin D corrected deficiency and lowered PTH (marker of calcium homeostasis) — strong biochemical support for bone health.

PubMed ID: 27418034

Vitamin‑D‑fortified cereal maintained 25(OH)D in adolescents and improved ferritin; maintenance of vitamin D status supports bone health.

PubMed ID: 30281106

Growing-up milk raised 25(OH)D substantially in toddlers and reduced deficiency prevalence—relevant to bone health in children.

PubMed ID: 32091548

Maternal high‑dose vitamin D in pregnancy increased offspring whole‑body BMC and BMD at ages 3–6 years—strong skeletal benefit.

PubMed ID: 36591342

Vitamin D increased 25(OH)D and modestly lowered PTH (especially with lower eGFR)—biochemical effects important for bone/mineral metabolism.

PubMed ID: 22024564

Daily milk product containing vitamin D raised serum 25‑OH‑D and improved bone turnover markers and estimated bone mass in postmenopausal women.

PubMed ID: 21528596

Calcichew D3 (calcium + vitamin D) plus acupoint therapy reduced pain and increased BMD vs calcium alone in postmenopausal osteoporosis, though multiple interventions were combined.

PubMed ID: 22190136

Formula containing vitamin D during weight-loss raised 25(OH)D, lowered PTH and produced small increases in BMD over 16 weeks.

PubMed ID: 2021135

Ergocalciferol markedly raised total 25‑OHD levels—supports improved vitamin D status that underpins bone health.

PubMed ID: 1578308

Randomized infant trial showed dose‑dependent increases in 25‑OHD and prevention of rickets—strong direct evidence for bone health in infants.

PubMed ID: 1427127

Fortified milk raised 25‑OH‑D substantially in elderly who are at risk of bone loss—supportive for bone health.

PubMed ID: 8590154

Daily 1000 IU prevented forearm bone loss in Crohn’s patients vs controls over one year — clinically meaningful preservation of BMD.

PubMed ID: 9771862

D3 raises 25(OH)D more effectively than D2 — better ability to achieve vitamin D levels that support bone health.

PubMed ID: 9886454

Active vitamin D (1α-OH D3) markedly slowed BMD loss and greatly reduced nonvertebral/hip fractures in elderly Parkinson's patients.

PubMed ID: 10443663

1,25(OH)2D3 partially attenuated leuprolide-induced spine BMD loss (modest protective effect).

PubMed ID: 10385063

Calcitriol reduced or prevented bone loss in patients with liver cirrhosis (randomized trial showing BMD benefit).

PubMed ID: 10213125

Calcitriol prevented annual spine bone loss in primary biliary cirrhosis (significant BMD preservation).

PubMed ID: 10769438

Alfacalcidol given 2 years reduced spinal bone loss in transplant recipients and RA patients versus controls.

PubMed ID: 11731184

Combination calcitonin + active vitamin D analogue increased lumbar spine BMD by >3% at 12 mo and >4% at 24 mo and reduced bone turnover markers.

PubMed ID: 12609940

Large randomized trial showed intermittent high-dose vitamin D3 reduced fractures (any and osteoporotic-site), directly supporting bone strength outcomes.

PubMed ID: 15575909

Alfacalcidol (active vitamin D) improved lumbar spine BMD z-scores and lowered PTH in young transplant recipients.

PubMed ID: 16586188

Vitamin D analog increased leg BMD and lowered bone resorption markers in spinal cord injury patients (RCT).

PubMed ID: 17159108

High-dose vitamin D improved BMD in anticonvulsant-treated adults (RCT), clear skeletal benefit.

PubMed ID: 17031013

Dose-dependent rises in serum 25-OHD and PTH trend to lowering support bone health via calcium/PTH axis.

PubMed ID: 16369892

Alfacalcidol added to HRT gave a substantial, significant lumbar spine BMD increase over 2 years.

PubMed ID: 17012108

Vitamin D3 added to K2 reduced some bone‑turnover markers — supports bone metabolism benefit in combination.

PubMed ID: 18058622

1,000 IU D3 five days/week increased 25(OH)D in disabled children without hypercalcemia—supports bone health via status correction.

PubMed ID: 17333451

Variation in PTH/PTHrP/1,25(OH)2D explained part of BMD response variability to PTH—links active vitamin D metabolism to bone outcome (indirect).

PubMed ID: 18326608

Single 100,000 IU cholecalciferol produced a large, sustained rise in 25(OH)D—pharmacologic correction that supports bone health over months.

PubMed ID: 18261575

Alfacalcidol (vitamin D analogue) plus alendronate produced clear spine/hip BMD increases in transplant recipients — strong bone density outcome though confounded by bisphosphonate.

PubMed ID: 19161542

Maternal and infant vitamin D supplementation improved infant 25(OH)D and breast‑milk antirachitic activity — important for infant bone/rachitic prevention.

PubMed ID: 19158226

Daily 20 µg vitamin D3 in young women raised 25(OH)D and achieved target levels — important precursor for bone health.

PubMed ID: 20683712

RCT in deficient immigrants: oral vitamin D reliably raised 25(OH)D and lowered PTH — biomarkers consistent with improved bone health potential.

PubMed ID: 21050796

Sunlight exposure raising vitamin D increased bone density and significantly reduced hip fractures in elderly Parkinson's patients over 2 years — strong bone-health evidence.

PubMed ID: 21479913

Alendronate tablets with high‑dose D3 corrected insufficiency and produced modestly larger BMD gains vs usual care in a randomized trial.

PubMed ID: 21706518

Pregnancy RCT: 4000 IU/day safely produced large increases in maternal and neonatal 25(OH)D that support bone health in mother/infant (surrogate outcome).

PubMed ID: 21996984

Monthly high-dose cholecalciferol in CKD raised 25(OH)D and lowered PTH—biochemical effects relevant to bone health.

PubMed ID: 21605716

Active vitamin D analog significantly improved hip vBMD, cortical thickness, and biomechanical indices over 144 weeks in osteoporotic patients—strong bone outcome evidence.

PubMed ID: 21971374

Low-dose vitamin D produced a modest femoral neck BMD improvement in chronic liver disease patients (randomized comparison).

PubMed ID: 21554143

Active vitamin D analogue added to alendronate reduced vertebral and weight-bearing fracture risk and low baseline 25(OH)D predicted fractures.

PubMed ID: 22097203

Calcichew D3 (calcium + vitamin D) as part of therapy improved some BMD measures vs calcium alone in postmenopausal osteoporosis context.

PubMed ID: 22998754

Overweight women RCT lowered PTH and raised 25(OH)D; while body-fat was primary, PTH decrease supports bone health.

PubMed ID: 22760564

Child supplementation increased growth (height) over 6 months—supports skeletal growth/health in children.

PubMed ID: 23123493

Large cross-sectional survey showing high rickets prevalence and deficiency — strong relevance to bone health and need for repletion.

PubMed ID: 23052606

Observational study: Parkinson's patients had lower 25(OH)D and more bone loss — association supports bone relevance.

PubMed ID: 22266572

RCT in children with CKD: ergocalciferol delayed secondary hyperparathyroidism and restored 25(OH)D—direct bone/metabolic protection.

PubMed ID: 23144810

Large cross‑sectional study showed widespread insufficiency and inverse correlations between 25(OH)D and PTH/bone‑turnover markers—strong bone health relevance.

PubMed ID: 22854402

High‑dose cholecalciferol in CKD raised 25(OH)D and produced an early PTH fall—biochemical bone‑health relevant effect.

PubMed ID: 22608570

In children with asthma, low vitamin D amplified oral‑steroid‑related deficits in bone mineral accretion—directly implicates vitamin D in bone accrual.

PubMed ID: 23129180

Eldecalcitol (active vitamin D analog) significantly reduced vertebral fractures vs alfacalcidol in large RCT.

PubMed ID: 23783292

Fortifying staple foods prevented winter deficiency and kept most participants above deficiency thresholds, directly relevant to bone health maintenance.

PubMed ID: 24368437

Dose–response trial quantified doses required to reach 25(OH)D thresholds often cited for bone health, directly informing skeletal dosing.

PubMed ID: 23912950

Analysis in women on alendronate showed higher achieved 25(OH)D modestly associated with greater spine and hip BMD gains.

PubMed ID: 23716156

RCT in pregnant women showing larger maternal doses were required to raise neonatal cord 25(OH)D above deficiency threshold—direct for neonatal bone-health related status.

PubMed ID: 23632722

Double-blind RCT in breastfed infants showed dose-dependent increases in plasma 25(OH)D and measured bone mineral content outcomes.

PubMed ID: 23335089

Vitamin D analogue produced marked PTH suppression (indicator of improved calcium/vitamin D action on bone metabolism).

PubMed ID: 23851699

Fortified milk prevented winter decline in preschoolers' 25(OH)D—supports maintenance of vitamin D status important for bone accrual.

PubMed ID: 23834479

IMPACT SHPT trial analysis: paricalcitol regimens achieved better iPTH control—relevant to bone health in dialysis patients.

PubMed ID: 23567070

Paricalcitol in kidney-transplant recipients lowered PTH and bone turnover markers and improved BMD—direct bone-strength evidence.

PubMed ID: 23559332

Infant RCT: 400 IU/day raised 25(OH)D more than 200 IU and prevented low vitamin D/rickets risk — direct strong evidence for bone health in infants.

PubMed ID: 23998516

Maternal third‑trimester vitamin D3 increased early infant linear growth and reduced stunting at 1 year — clinically meaningful bone/growth benefit.

PubMed ID: 23427068

Observational study: patients with new vertebral fractures had higher prevalence of vitamin D deficiency — supports association between low vitamin D and fracture risk.

PubMed ID: 24467642

ART trials: patients (especially on efavirenz) had vitamin D declines and larger BMD losses — links vitamin D status changes to bone outcomes.

PubMed ID: 24515510

Daily 800 IU vs 400 IU in preterm infants substantially reduced prevalence of vitamin D deficiency though bone mineral content/density were unchanged.

PubMed ID: 24189972

Prospective cohort: lower maternal vitamin D in pregnancy associated with lower offspring total bone mass at 20 years—strong human evidence for skeletal impact.

PubMed ID: 24825262

Pediatric rickets RCT: high single oral doses achieved 100% radiographic healing by 12 weeks—direct bone health benefit.

PubMed ID: 24719139

Alendronate + weekly vitamin D raised 25OHD and blunted PTH rise vs alendronate alone—relevant to bone health maintenance.

PubMed ID: 25572630

CKD RCT with modified‑release calcifediol: rapid dose‑dependent increases in 25OHD and clinically meaningful iPTH reductions—supports bone/mineral benefit.

PubMed ID: 25417309

Active vitamin D substantially improved interbody fusion rates and functional outcome in osteoporotic lumbar fusion patients — strong bone/healing evidence.

PubMed ID: 25799402

2‑yr RCT: vitamin D 800 IU maintained femoral neck BMD and tibial trabecular density — randomized support for bone maintenance.

PubMed ID: 26460504

Switching ARV regimen raised vitamin D modestly and produced consistent small BMD increases (~2–3%) with improved bone markers — direct bone benefit.

PubMed ID: 26707619

Adolescent RCT reliably corrected deficiency and achieved sufficiency in most — achieving sufficiency is important for bone accrual in youth.

PubMed ID: 25582182

Single 50,000 IU neonatal dose safely raised infant 25(OH)D and prevented deficiency—relevant to bone development.

PubMed ID: 25707402

Large prospective study: higher 25(OH)D strongly associated with higher hip BMD, slower loss and substantially lower hip fracture risk — strong bone support.

PubMed ID: 26030788

Premature infant RCT: 800 vs 400 IU/d produced larger rises in total and free 25(OH)D and free vitamin D at birth correlated with bone mineral content — direct neonatal bone relevance.

PubMed ID: 40551234

Higher postop 25‑OH D linked to better sternal bone healing grades after sternotomy.

PubMed ID: 41277643

Improved radiographic bone healing and bone quality measures in periapical lesions after vitamin D supplementation supports bone repair.

PubMed ID: 40556294

Vitamin D was part of a regimen post‑hip arthroplasty that improved bone‑markers and function (confounded).

PubMed ID: 41054075

Regimens including calcitriol produced larger BMD gains after kyphoplasty vs calcitriol alone (confounded by other drugs).

PubMed ID: 40660276

Oral nutritional supplement including vitamin D increased 25(OH)D, total body BMD and lean mass in undernourished preschool children — direct bone benefit.

PubMed ID: 40445221

Chinese women given 400–800 IU/day increased 25(OH)D and reduced PTH, reflecting improved vitamin D status relevant to bone health.

PubMed ID: 40005002

Calcifediol rapidly and reliably restored 25(OH)D and lowered PTH, supporting bone‑health physiology.

PubMed ID: 38726565

Large maternal dosing trial substantially reduced infant biochemical rickets — direct and large skeletal benefit for infants.

PubMed ID: 38999892

High maternal dose greatly raised neonatal 25(OH)D and markedly reduced neonatal deficiency — supports infant bone health.

PubMed ID: 39599585

Rapid, reliable correction of deficiency (25(OH)D) is a prerequisite for optimal calcium/bone metabolism.

PubMed ID: 39306330

Pregnancy RCT (1000 IU/d) produced higher offspring BMD/BMC at 6–7 years—strong evidence for bone benefit in offspring.

PubMed ID: 37119106

Observational study found low preop 25(OH)D an independent risk factor for treated vertebra recompression—supports bone health link.

PubMed ID: 37390941

High bolus vitamin D in CF reduced bone resorption (CTX‑1) and formation (P1NP) markers—direct bone metabolism effect.

PubMed ID: 37544395

Higher 25(OH)D modestly associated with better spine trabecular bone score in older women.

PubMed ID: 37871795

Maternal vitamin D dosing strongly reduced rickets incidence in offspring—direct bone health benefit.

PubMed ID: 37409797

Metabolite analyses linked higher downstream catabolites to bone loss, highlighting vitamin D metabolic effects on bone.

PubMed ID: 37375660

In toddlers daily vitamin D (1000 IU D3) reliably raised serum 25(OH)D and reduced deficiency — clear support for bone health in growing children.

PubMed ID: 35988059

Bioequivalence of eldecalcitol formulations (an active vitamin D analogue used for osteoporosis) directly relates to therapeutic bone effects.

PubMed ID: 35034345

Demonstrates effective systemic 25(OH)D exposure from an orodispersible formulation, supporting ability to influence bone biology.

PubMed ID: 35533340

Active vitamin D was part of standard therapy in XLH comparator arm; trial addresses phosphate/bone markers and shows role of vitamin D in conventional care.

PubMed ID: 35692883

Calcitriol + zoledronic acid trial showed superior BMD gains, bone-turnover reductions and fewer refractures vs calcitriol alone.

PubMed ID: 35015806

In children, supplementation prevented winter decline in 25(OH)D (important for bone health) and was part of a trial measuring body composition outcomes.

PubMed ID: 34849546

2000 IU/day reduced PTH overall and substantially in those with baseline 25(OH)D <20 ng/mL—strong trial support for improved bone‑mineral regulatory physiology.

PubMed ID: 35122668

Exclusive‑breastfed infant trial: 400 IU/day raised 25(OH)D, lowered iPTH and supported growth indices — strong for bone health.

PubMed ID: 36148748

Infant RCT: daily 400 IU prevented rickets and achieved sufficiency — direct, strong bone health evidence.

PubMed ID: 36190481

High‑dose ergocalciferol more effectively normalized 25(OH)D in epileptic youth (AEDs increase bone risk) — relevant to bone protection.

PubMed ID: 36286834

Selective VDRA more often normalized PTH and increased protective Klotho in CKD—meaningful effects on mineral metabolism and bone health.

PubMed ID: 34393156

Eldecalcitol (active vitamin D analog) plus zoledronic acid suppressed bone turnover markers and is directly relevant to bone strength/therapy in osteoporosis patients.

PubMed ID: 34581765

Supplementation in 6–8‑year‑olds increased some lumbar spine BMD and TBLH BMC measures vs placebo (direct bone mass benefit).

PubMed ID: 34101900

Calcifediol produced faster and larger increases in total and free 25(OH)D in postmenopausal women — relevant to correcting deficiency for bone outcomes.

PubMed ID: 34578863

Vitamin D‑fortified cheese in vitamin D‑insufficient early postmenopausal women raised 25(OH)D and reduced bone resorption markers — clear bone benefit.

PubMed ID: 34392411

Children with CKD: 4000 IU/day far more effective at achieving vitamin D sufficiency without toxicity — supports bone health maintenance.

PubMed ID: 33478397

In hip fracture patients higher weekly ergocalciferol restored vitamin D sufficiency in far more patients — directly relevant to bone recovery/supplementation.

PubMed ID: 34845313

In pediatric hemodialysis, vitamin K2 + native vitamin D produced greater reductions in calcification‑related biomarkers (dp‑uc‑MGP, uc‑OC) — relevant to bone/vascular calcification, though effect was in combination therapy.

PubMed ID: 32415923

Calcitriol + sevelamer improved iPTH and mineral markers in CKD (vitamin D agent effect on bone/mineral metabolism).

PubMed ID: 31518424

25‑OH‑D3 is ~3× more potent at raising serum 25(OH)D, supporting repletion relevant to bone health.

PubMed ID: 32181677

Maternal supplementation during lactation markedly raised infant 25(OH)D and reduced deficiency—important for infant bone/teeth development.

PubMed ID: 32052217

Dose‑response study showed vitamin D dose‑dependent 25(OH)D increases and lowering of PTH—central to bone/mineral metabolism.

PubMed ID: 30798000

Pregnant women given 1000 IU/day had increased fetal femur/humerus lengths and bone diameters on ultrasound—robust bone-development signal.

PubMed ID: 31731651

Calcifediol raised 25(OH)D faster and lowered PTH more than cholecalciferol in very old adults, improving bone‑relevant biochemistry.

PubMed ID: 30898175

Micellised vitamin D produced larger 25(OH)D increases and lowered PTH more than standard capsules—supportive of bone/calcium homeostasis.

PubMed ID: 30624670

Monthly dosing increased 25(OH)D and lowered PTH dose-dependently—mechanistically relevant to bone health despite no BMD change at 1 year.

PubMed ID: 30852657

Food fortification substantially raised vitamin D status and eliminated severe deficiency—a preventive bone-health benefit.

PubMed ID: 31104833

Burosumab trial used active vitamin D as conventional therapy; shows importance of vitamin D physiology in rickets/bone outcomes.

PubMed ID: 29439405

Cholecalciferol in dialysis raised 25(OH)D, lowered PTH and improved femoral neck BMD—direct bone benefit.

PubMed ID: 29968187

Patients with 25(OH)D >50 nmol/L lost significantly less hip bone after gastric bypass—strong clinical bone-protection signal.

PubMed ID: 29481636

In children with CKD, vitamin D normalized Klotho and sclerostin in milder CKD, indicating beneficial bone/mineral effects (but raised FGF23 in advanced CKD).

PubMed ID: 30293198

RCT in postmenopausal women showed improvements in bone microstructure and estimated failure load/stiffness after supplementation.

PubMed ID: 28318867

Alfacalcidol modestly slowed bone loss after hip replacement (vitamin D analogue effect), though alendronate was superior.

PubMed ID: 29016653

In very preterm infants, 800 IU/day raised 25(OH)D faster and markedly reduced the proportion with low bone mineral content at term (randomized NICU trial).

PubMed ID: 28346568

Post–hip-fracture calcifediol alongside exercise raised 25(OH)D and was associated with better survival and presumed bone-supportive care (confounded).

PubMed ID: 28397581

Active vitamin D analog plus denosumab improved femoral neck BMD vs denosumab + native vitamin D (site-specific BMD gain).

PubMed ID: 28902705

In HIV-infected youth higher vitamin D lowered bone turnover markers and raised 25(OH)D; BMD benefit not definitive but bone biomarker improvement clear.

PubMed ID: 27837387

Loading doses after bariatric surgery more effectively restored 25(OH)D and suppressed PTH (relevant to bone health and calcium economy).

PubMed ID: 28692172

Large BMD substudy showed ~2% BMD gains in markedly deficient older adults—suggesting bone benefit when deficient.

PubMed ID: 29152675

In juvenile‑onset SLE, weekly cholecalciferol improved trabecular microarchitecture measured by HR‑pQCT—a robust structural bone effect.

PubMed ID: 28679555

Large RCT showed vitamin D3 raised wintertime 25(OH)D much more than D2—improving the key surrogate (25OHD) for bone health.

PubMed ID: 27449925

Food‑based RCT (fortified Gouda) prevented winter decline in 25(OH)D in postmenopausal women—useful for bone health maintenance.

PubMed ID: 27189286

Descriptive repletion data in postmenopausal women showed ~2000 IU/day repleted most within ~1 month—practical evidence for bone‑relevant repletion.

PubMed ID: 27184759

Maternal/infant supplementation prevented low infant 25(OH)D and lowered elevated alkaline phosphatase (marker of rickets/bone turnover) — strong pediatric bone evidence.

PubMed ID: 27631092

Cross‑sectional analysis showed associations between 25(OH)D below ~29–33 nmol/L and lower BMD—supports role of vitamin D in bone health at low levels.

PubMed ID: 27079965

In extremely preterm infants higher intake normalized 25(OH)D and eliminated biochemical deficiency—important for neonatal bone mineralization even though clinical endpoints unchanged.

PubMed ID: 28065190

In CKD patients cholecalciferol raised 25(OH)D more and lowered PTH more than ergocalciferol—favors bone/mineral effects.

PubMed ID: 27535752

Dose-dependent vitamin D prevented cortical tibial thinning over 1 year in older women—direct bone geometry benefit.

PubMed ID: 26308708

Alfacalcidol (vitamin D analogue) plus alendronate prevented glucocorticoid‑induced bone loss and reduced fractures over 1 year.

PubMed ID: 26209166

Active vitamin D analog (eldecalcitol) improved muscle strength and balance in osteoporotic women, outcomes relevant to fracture prevention and bone health context.

PubMed ID: 17277040

In older adults with impaired fasting glucose, Ca+D slowed glycemic deterioration over 3 years—metabolic benefit relevant to healthy aging.

PubMed ID: 38447788

One-year vitamin D repletion in adults with deficiency improved thigh (quadriceps) strength, relevant to age-related functional preservation (moderate direct evidence).

PubMed ID: 21807930

Post-hoc analysis showed muscle-strength gains from a supplement occurred only in participants with 25(OH)D ≥30 ng/mL, indicating vitamin D sufficiency modifies age-related strength responses.

PubMed ID: 25480348

Adding a D-hormone analog (alfacalcidol) to strontium ranelate improved BMD and functional tests in postmenopausal osteoporosis—clinically relevant for older adults.

PubMed ID: 31296588

12‑month 800 IU/day RCT in older adults with Alzheimer’s reported modest cognitive improvements and favorable amyloid‑biomarker changes.

PubMed ID: 29151102

Postmenopausal study: vitamin D increases associated with expected reductions in PTH and bone‑turnover markers relevant to aging bone health.

PubMed ID: 31197107

Institutionalized elderly given a protein‑vitamin drink (including vitamin D) showed modest 25(OH)D increases and functional improvements—relevant to healthy aging.

PubMed ID: 25646324

Preserved appendicular muscle mass in older obese adults during diet + resistance training with protein/leucine/vitamin D—supports sarcopenia prevention.

PubMed ID: 26170041

Sarcopenic older adults gained muscle mass and improved function on vitamin D + leucine‑enriched protein.

PubMed ID: 31049877

Attenuation of IL‑6 rise in older adults suggests reduced inflammaging with vitamin D‑containing supplement.

PubMed ID: 31278117

Improved mobility and muscle mass during rehab in Parkinson’s patients with a vitamin D‑containing supplement—functional aging benefit.

PubMed ID: 31338563

Large trial in older sarcopenic adults: supplement with vitamin D raised 25(OH)D, lowered PTH and produced small BMD gains—relevant to healthy aging.

PubMed ID: 34838980

Supplement containing vitD plus resistance exercise increased mid‑thigh muscle CSA in adults ≥50—helps preserve muscle with age.

PubMed ID: 33067129

Fortified HMB + vitD/C yogurt improved strength and gait speed in sarcopenic older adults (multi‑ingredient but relevant to aging).

PubMed ID: 2387950

Daily vitD+calcium corrected 25(OH)D in elderly women with no safety issues—relevant to older adult nutrition/health maintenance.

PubMed ID: 7684512

Calcitriol mitigated lumbar spine bone loss in steroid-treated patients, a clinically meaningful bone‑protective effect relevant to aging.

PubMed ID: 8461542

Calcitriol with calcium substantially prevented lumbar spine bone loss in patients starting long-term steroids—relevant to preserving bone with aging.

PubMed ID: 8131343

3‑year prevention of radial bone loss in postmenopausal women supports healthy aging/fragility prevention.

PubMed ID: 8172088

Single high dose raised 25(OH)D and lowered PTH in older adults—supports age-related bone health maintenance.

PubMed ID: 8062152

RCT showed fewer vertebral fractures and preserved spine BMD in older osteoporotic women—direct aging-relevant benefit.

PubMed ID: 7714065

Large RCT in older women showed improved 25-OH-D, lower PTH and small femoral neck BMD gain—relevant to healthier bone aging and frailty prevention.

PubMed ID: 7677827

Active vitamin D analogue prevented renal bone disease progression and improved histology—supports healthier aging in renal patients.

PubMed ID: 7733040

Higher daily vitamin D (700 IU) modestly reduced femoral neck bone loss in older/calcium-supplemented women—supports aspects of healthy aging.

PubMed ID: 7781871

Combination including 1alpha-vitamin D largely prevented vertebral bone loss in postmenopausal women—relevant to aging-related bone preservation.

PubMed ID: 9026268

1α‑OH vitamin D3 increased spine BMD and fewer fractures over 2 years — supports bone health in aging.

PubMed ID: 8633378

Alphacalcidol reduced early post‑transplant bone loss — relevant to maintaining bone health with age/medical stress.

PubMed ID: 9278463

Daily Ca + 700 IU D3 modestly preserved BMD and reduced nonvertebral fractures in older adults — direct healthy aging relevance.

PubMed ID: 9099188

Active vitamin D + calcium preserved BMD and reduced hip fractures in hemiplegic stroke patients—clinically relevant for older adults.

PubMed ID: 9388377

Alfacalcidol increased spine/radius BMD and reduced vertebral fractures in elderly osteoporosis patients.

PubMed ID: 9797910

Calcium + vitamin D increased spine BMD in early postmenopausal women — relevant to age‑related bone loss prevention.

PubMed ID: 9718191

Oral vitamin D3 and UV-B corrected deficiency and lowered PTH in very elderly nursing-home women—relevant to healthier aging via bone/metabolic benefits.

PubMed ID: 9504953

Vitamin D–fortified milk doubled low 25OHD in elderly over one year, supporting correction of deficiency in older adults.

PubMed ID: 9797906

Dose–response study establishes predictable increases in circulating 25(OH)D with oral D3—useful for aging-related supplementation strategies.

PubMed ID: 11297596

Vitamin D3 + calcium in older women increased 25OHD, lowered PTH and reduced systolic blood pressure, relevant to age-related cardiovascular risk.

PubMed ID: 11991447

Large RCT in institutionalized elderly showed Ca+vitamin D restored 25OHD, normalized PTH and prevented hip bone loss—relevant to healthy aging.

PubMed ID: 14652238

Higher 25-OHD plus calcium linked to lower colorectal adenoma recurrence—relevant to long-term healthy aging/cancer prevention.

PubMed ID: 15040824

Large pragmatic program with calcium + 400 IU vitamin D reduced osteoporotic fractures in older community residents.

PubMed ID: 14602746

Calcium + vitamin D in elderly low‑D women improved 25‑OHD, decreased PTH and bone turnover, and raised BMD—benefits relevant to aging bone health.

PubMed ID: 12913194

Sunlight (raising vitamin D) in vitamin‑D deficient stroke patients increased BMD and reduced hip fractures—relevant to healthy aging and fracture prevention.

PubMed ID: 14513268

Alfacalcidol vs vitamin D3 improved long-term BMD and markedly reduced fractures in glucocorticoid‑treated patients — relevant to preservation of bone health with aging.

PubMed ID: 15231008

Winter vitamin D3 + calcium prevented seasonal bone loss in healthy adults, supporting maintenance of bone health over time.

PubMed ID: 15501704

Daily calcium + vitamin D prevented annual bone loss in peri/postmenopausal women — contributes to healthy aging of the skeleton.

PubMed ID: 14695863

In elderly hip-fracture patients vitamin D improved vitamin D status, BMD modestly and reduced falls — relevant to healthy aging.

PubMed ID: 14728632

Alfacalcidol reduced number of fallers in elderly subgroup with adequate calcium—relevant to aging outcomes.

PubMed ID: 16491287

Vitamin D3‑fortified milk in older men increased 25(OH)D, lowered PTH and slowed bone loss — supports age‑related bone preservation.

PubMed ID: 16007329

Sunlight exposure in elderly with Alzheimer raised 25‑OH D, improved BMD and reduced nonvertebral fractures — relevant to aging outcomes.

PubMed ID: 16274368

Daily vitamin D (with calcium) reduced falls in older residential‑care residents, a key healthy‑aging outcome.

PubMed ID: 16505262

Large RCT: daily vitamin D (700 IU) + calcium reduced falls in older women, a clinically meaningful healthy-aging outcome.

PubMed ID: 17236758

Calcitriol reduced falls in older women (especially with low renal function) — clinically meaningful outcome linked to healthier aging.

PubMed ID: 17556697

Calcium plus moderate-dose vitamin D3 was associated with substantially lower overall cancer incidence (secondary outcome), relevant to healthier aging.

PubMed ID: 17874029

Nursing-home RCT: daily/interval vitamin D substantially raised 25(OH)D and lowered PTH—relevant to bone health and aging-related deficiency.

PubMed ID: 18629569

RCT (Ca + 800 IU D) in older adults reduced first falls and improved leg strength/mobility — clinically relevant to healthy aging.

PubMed ID: 19729890

Monthly high‑dose vitamin D raised 25(OH)D and improved leg strength in older residents — relevant to healthy aging and independence.

PubMed ID: 19258546

Vitamin D increased pro‑apoptotic marker (Bax) in colon mucosa — biological effect relevant to long‑term tissue health/aging.

PubMed ID: 20516268

800 IU/day reliably raised 25(OH)D in older adults and helped many reach sufficiency—useful for age‑related deficiency prevention.

PubMed ID: 19185400

Large RCT in elderly women with CKD: vitamin D3 increased 25(OH)D and lowered iPTH—clinically relevant effects for aging bone/metabolic health.

PubMed ID: 19244376

High‑dose (5000 IU) daily fortification in nursing‑home residents produced large biochemical and BMD improvements relevant to healthy aging.

PubMed ID: 19262561

Active vitamin D + Ca improved spine BMD in elderly women compared with Ca+vitD alone, relevant to healthy skeletal aging.

PubMed ID: 19297462

Dose‑response RCT in older adults defining intakes needed to maintain target 25(OH)D—directly applicable to aging populations.

PubMed ID: 20056649

Vitamin D (±calcium) reduced colorectal oxidative DNA damage marker, especially in VDR-high subgroup — plausible mechanism for healthier aging/cancer prevention.

PubMed ID: 20370938

30-month fortified-dairy (vitamin D + calcium) produced meaningful BMD gains in postmenopausal women — relevant to healthy skeletal aging.

PubMed ID: 21880848

Reanalysis of a large RCT (Ca+D) showed lower total and breast cancer incidence in women not previously supplementing — relevant to aging/cancer risk.

PubMed ID: 21784190

Active vitamin D analog (eldecalcitol) RCT reduced vertebral fractures and increased BMD — strong outcome relevant to aging and fracture prevention.

PubMed ID: 23208074

WHI Ca+D trial: overall small effects but subgroup showed fewer hip fractures after long-term use in non‑users — moderate evidence for aging-related fracture prevention.

PubMed ID: 22431675

Dose–response in postmenopausal women showing reliable repletion and PTH effects—important for aging bone health.

PubMed ID: 22551881

Large RCT in elderly women: 800 IU+D raised 25(OH)D and slowed wrist BMD loss—directly relevant to healthy aging.

PubMed ID: 23591713

High‑dose cholecalciferol in deficient obese adults lowered PTH and gave a small but significant forearm BMD increase—relevant to bone health with aging.

PubMed ID: 23579066

Multifactorial falls program including calcium/vit D reduced falls/injuries—supports aging resilience (vitamin D contribution uncertain).

PubMed ID: 23585346

Well-powered RCT: 1000 IU/day attenuated hip bone loss in postmenopausal women—relevant to healthy aging.

PubMed ID: 23799356

Large RCT showed Ca+D augmented hip‑fracture protection with hormone therapy — clinically relevant for aging fracture risk.

PubMed ID: 25962885

Long-term care knowledge-translation intervention substantially increased appropriate ≥800 IU vitamin D prescribing in older residents—directly relevant to healthy aging implementation.

PubMed ID: 25656524

Large single 25‑OH vitamin D dose in dialysis patients raised vitamin D metabolites and transiently lowered PTH—metabolic effects important for aging bone/mineral health.

PubMed ID: 25899914

Calculated loading regimen rapidly normalized 25(OH)D in frail nursing-home residents—correction of deficiency relevant to healthy aging outcomes (falls, bone health).

PubMed ID: 26782853

Dose–response vitamin D3 in very elderly produced reliable 25(OH)D increases and PTH safety data — directly relevant to older adults.

PubMed ID: 27986983

Yearlong randomized dosing in older adults normalized 25(OH)D and lowered PTH — supports vitamin D for aging populations.

PubMed ID: 27058906

In chronic heart‑failure patients, high‑dose D3 improved cardiac remodeling over 12 months — clinically meaningful in an older/chronically ill group.

PubMed ID: 28350929

Large RCT in older women raised 25(OH)D and showed a non-significant trend to lower all-cancer incidence — relevant to healthy aging outcomes.

PubMed ID: 28148500

Long Ca+D RCT showed fracture risk reduction in a genetic low‑risk subgroup—relevant to bone health in ageing.

PubMed ID: 29676968

Two-year randomized trial of daily vitamin D/calcium–enriched milk increased femoral neck BMD and improved metabolic markers in postmenopausal women—supports healthy aging (bone and metabolic domains).

PubMed ID: 30557404

Vitamin D (±calcium) shifted colorectal mucosal markers toward less proliferation/more apoptosis—plausible anti‑neoplastic/healthy‑aging effect.

PubMed ID: 29665087

Reanalysis: vitamin D increased BMD in postmenopausal women who were deficient (benefit for bone health with aging, subgroup‑specific).

PubMed ID: 32857128

HMB+vitamin D3 improved muscle function and strength in older adults—supports aspects of healthy aging though multi-ingredient intervention.

PubMed ID: 32090730

Large elderly repletion trial providing strong evidence that vitamin D status can be corrected in older adults, relevant to aging-related health maintenance.

PubMed ID: 33280041

Dose‑dependent increases in total/free 25(OH)D in older adults with modest correlations to PTH and site‑specific BMD—supports aging bone health.

PubMed ID: 33951328

Elderly osteoporotic patients receiving active vitamin D, calcium and exercise had improved strength/function and lumbar BMD—relevant to healthy aging.

PubMed ID: 33888407

Brief supervised sun exposure in nursing‑home residents produced clinically meaningful rises in 25(OH)D in elderly — relevant to healthy aging.

PubMed ID: 33954783

Higher daily D3 reliably achieved sufficiency in overweight/obese elderly — supports maintenance of vitamin D status in aging populations.

PubMed ID: 34936992

Five-year education increased vitamin D supplement use and was associated with higher BMD and fewer fractures in elderly women, relevant to healthy aging.

PubMed ID: 40259289

HIIT plus daily vitamin D in osteoporosis patients increased 25‑OH‑D and improved BMD and bone markers—meaningful for musculoskeletal aging.

PubMed ID: 37949432

Multidomain intervention raising serum vitamin D was associated with improved intrinsic capacity in older multimorbid adults (clinically relevant ageing outcome).

PubMed ID: 21986389

VITAL is a large RCT designed to test long‑term vitamin D for cancer/CVD prevention — relevant to healthy aging.

PubMed ID: 25864623

VITAL trial update/ongoing trial testing 2000 IU/day in older adults for primary prevention.

PubMed ID: 26767629

Baseline/description paper for the large VITAL cohort (supports applicability to aging populations).

PubMed ID: 18043700

In aged‑care residents a multivitamin (including vitamin D) increased 25(OH)D and improved heel QUS (bone quality) and trended to fewer falls — supports healthy aging outcomes.

PubMed ID: 16088114

Randomized vitamin D (1,000 IU) after stroke markedly reduced falls and hip fractures and improved type II muscle fiber size—clinically relevant to aging outcomes.

PubMed ID: 40409468

Large RCT substudy: 2000 IU/day slowed leukocyte telomere shortening over 4 years (direct biomarker relevant to cellular aging).

PubMed ID: 31464392

Institutionalized older adults: vitamin D (in micronutrient pack) markedly raised 25(OH)D and improved antioxidant markers relevant to healthy aging.

PubMed ID: 28539168

Post‑hip‑fracture supplementation (HMB + vitamin D) helped preserve muscle mass in older patients—relevant to sarcopenia prevention.

PubMed ID: 33268143

Large RCT in older, malnourished adults: ONS with vitamin D improved weight, function and vitamin D sufficiency—supports aging outcomes.

PubMed ID: 40158795

Active vitamin D (eldecalcitol) RCT increased muscle mass/strength and altered anabolic signalling in older adults—relevant to sarcopenia and healthy aging.

PubMed ID: 40421021

RCT showed vitamin D reduced cellular markers of immunosenescence, supporting biological healthy‑aging effects.

PubMed ID: 36591342

Large trial: vitamin D raised 25(OH)D and modestly lowered PTH (biochemical changes relevant to aging/bone metabolism) though no CV/cancer benefit.

PubMed ID: 1427127

Vitamin D‑fortified milk substantially increased 25‑OH‑D in institutionalized elderly, supporting improved vitamin D status in an aging population.

PubMed ID: 7594162

In frail, vitamin D‑deficient elders, modest increases in 25(OH)D were associated with better functional status — relevant to healthy aging.

PubMed ID: 8590154

Daily 1000 IU largely prevented forearm bone loss in Crohn’s patients — preserves skeletal health with aging implications.

PubMed ID: 9886454

Active vitamin D in elderly Parkinson patients greatly reduced bone loss and nonvertebral/hip fractures (clinically important for aging).

PubMed ID: 10385063

Calcitriol prevented or reduced bone loss in patients with liver cirrhosis (supports preservation of bone with aging-related relevance).

PubMed ID: 10213125

Calcitriol prevented annual bone loss in primary biliary cirrhosis (helps maintain skeletal health in chronic disease/aging).

PubMed ID: 10769438

Alfacalcidol slowed spinal bone loss over 2 years in transplant and RA patients, relevant to skeletal aging.

PubMed ID: 11731184

Combination calcitonin + active vitamin D analogue increased spine BMD and reduced bone turnover in early postmenopausal women (age-related bone benefit).

PubMed ID: 12609940

Large long-term trial of intermittent high-dose vitamin D3 reduced fractures, an outcome relevant to healthy aging.

PubMed ID: 15501836

Vitamin D improved muscle and balance tests in older fallers, reducing frailty-related risk.

PubMed ID: 14961167

Vitamin D + K supplementation preserved carotid elastic properties over 3 years, a marker of vascular aging.

PubMed ID: 17159108

High-dose vit D improved BMD in adults on anticonvulsants—relevant to skeletal health in aging.

PubMed ID: 17031013

Dose-dependent increases in 25-OHD in elderly women and PTH lowering in responders—supports aging-related bone/endo health.

PubMed ID: 16369892

Alfacalcidol added to HRT produced larger lumbar BMD gains in older women.

PubMed ID: 17032712

Calcitriol significantly reduced falls in elderly women — clinically relevant to functional aging.

PubMed ID: 17388667

Observational: low vitamin D metabolites associated with higher risk of aggressive prostate cancer (aging‑related cancer outcome).

PubMed ID: 18279409

Single large D2 dose improved endothelial function and lowered systolic BP in vitamin D‑insufficient T2D—cardiovascular healthy‑aging relevance.

PubMed ID: 20625021

Large prospective cohort: low baseline 25(OH)D associated with faster cognitive decline over ~6 years (supports brain/aging link).

PubMed ID: 21050796

Regular sunlight (raising vitamin D) increased BMD and reduced hip fractures in elderly Parkinson's patients — clinically relevant to healthy aging.

PubMed ID: 21986705

Increase in PBMC telomerase activity (cellular aging biomarker) after supplementation suggests a potential healthy-aging signal.

PubMed ID: 21605716

Active vitamin D analog (eldecalcitol) improved hip bone density/geometry and biomechanical indices in osteoporosis—relevant to healthy aging and fracture prevention.

PubMed ID: 21554143

Active vitamin D analogue added to alendronate reduced fracture risk in older patients—relevant to healthy aging outcomes.

PubMed ID: 23066119

Pilot in older adults showed dose‑dependent increases in 25(OH)D and feasibility for prevention trials targeting older populations.

PubMed ID: 22613271

Megadose in elderly improved muscle strength and SPPB scores—functional benefits important for healthy aging.

PubMed ID: 23009149

Exercise+nutrition program raised vitamin D modestly and improved frailty and short‑term bone measures in older adults.

PubMed ID: 23129180

Active vitamin D analog reduced vertebral fractures and improved QOL in older patients—relevant to healthy aging.

PubMed ID: 22705148

Observationally higher baseline 25‑OH vitamin D associated with lower 1‑year mortality after hip fracture in older adults.

PubMed ID: 24135218

Low 25(OH)D associated with ~2.9-fold higher risk of adverse renal outcomes/death in diabetic nephropathy cohort.

PubMed ID: 23602862

Large observational cohort showed lower 25(OH)D associated with higher prevalence and size of AAAs—relevance to vascular aging.

PubMed ID: 24467642

Pooled ART trials: older patients had larger vitamin D declines and greater BMD loss — links vitamin D dynamics to age‑related bone loss.

PubMed ID: 25006678

Ergocalciferol improved microvascular endothelial function and reduced tissue oxidative-stress marker in CKD—mechanisms relevant to vascular aging.

PubMed ID: 25799402

2‑yr RCT in older women: vitamin D maintained some bone measures though did not reduce falls — moderate support for bone-related healthy aging.

PubMed ID: 25707402

Large prospective study in older men: higher 25(OH)D linked to higher hip BMD, slower bone loss and substantially lower hip fracture risk — relevant to healthy aging.

PubMed ID: 26209166

Eldecalcitol (active vitamin D analog) improved muscle strength and dynamic balance in older postmenopausal women with osteoporosis—falls/frailty relevant.

PubMed ID: 26277680

High-dose monthly vitamin D in homebound older adults greatly raised 25(OH)D and was associated with ~50% fewer falls—relevant to aging/frailty prevention.

PubMed ID: 26554884

In postmenopausal women with prior falls, daily vitamin D improved balance and reduced falls—important for aging.

PubMed ID: 27535752

Higher daily vitamin D prevented cortical bone thinning during weight loss in older women—supports skeletal aging.

PubMed ID: 27631092

Cross‑sectional data show bone density and balance associations below vitamin D thresholds—relevant to aging‑related fracture risk.

PubMed ID: 27049526

Pooled/observational evidence linking sustained higher 25(OH)D (≥40 ng/mL) with substantially lower non‑skin cancer incidence—relevant to long‑term aging outcomes.

PubMed ID: 27049643

Dose‑response RCT showed vitamin D increased global DNA methylation, a biomarker relevant to aging biology.

PubMed ID: 28323044

Dose-ranging RCT in older women showed medium daily doses reduced falls (important for healthy aging), with U‑shaped risk at high doses.

PubMed ID: 28692172

BMD substudy showed bone density benefit in markedly deficient older adults—a finding relevant to healthy aging/fracture risk.

PubMed ID: 28549923

Maintaining vitamin D sufficiency associated with less knee cartilage loss, less synovitis and better function over 2 years (joint aging outcomes).

PubMed ID: 28274889

Monthly vitamin D modestly slowed MRI‑measured joint effusion‑synovitis progression—supports preservation of joint health with aging.

PubMed ID: 28346568

Marked survival benefit after hip fracture with calcifediol plus exercise suggests potential healthy-aging impact (confounded).

PubMed ID: 30255229

Older women with higher 25(OH)D had ~40% fewer falls, an outcome relevant to healthy aging and independence.

PubMed ID: 30333271

Immunoregulatory benefits documented in frail older adults could support healthier aging immune profiles.

PubMed ID: 30852657

Fortification prevented winter deficiency in women—relevant to healthy aging by preventing deficiency-related risks.

PubMed ID: 30256915

16‑week trial showed modest reductions (~1.8–1.9 years) in epigenetic age measures with higher vitamin D doses.

PubMed ID: 31200560

In metabolic patients, vitamin D reduced oxidative DNA damage and improved insulin resistance and HDL—mechanisms linked to healthier aging.

PubMed ID: 33164936

In MCI patients 12 months of 800 IU/day improved global cognitive scores, reduced oxidative stress and lengthened telomeres—biomarkers and function relevant to healthy aging.

PubMed ID: 33478397

After hip fracture, higher weekly ergocalciferol corrected deficiency in more patients — relevant to bone health in older adults.

PubMed ID: 34894861

In care‑home older adults, combined whey+vitamin D+resistance training increased lean mass over 24 weeks — supports aspects of healthy aging.

PubMed ID: 34393156

Eldecalcitol (active vitamin D analog) with zoledronic acid suppressed bone turnover (bone health relevant for healthy aging), though short‑term BMD gain not greater.

PubMed ID: 36272926

Frail elderly showed modest muscle strength gains with protein+vitamin D—relevant to maintaining function with age.

PubMed ID: 37289007

Higher baseline 25(OH)D associated with improved DFS and OS in stage III colon cancer patients (better long‑term outcomes).

PubMed ID: 38437855

Active vitamin D analog (eldecalcitol) halved incident sarcopenia over 3 years—directly relevant to healthy aging.

PubMed ID: 40735907

Exercise plus vitamin D in postmenopausal women improved gait speed/strength — relevant to healthy aging and function.

PubMed ID: 41485966

Nutritional rehab including vitamin D improved muscle strength, cognition and QoL in elderly with sarcopenia/cognitive impairment.

PubMed ID: 34459959

Daily 2000 IU improved histologic and metabolic liver outcomes in children with NAFLD — meaningful wellness improvement.

PubMed ID: 18544622

Shows reliable restoration of 25(OH)D across dosing regimens in elderly patients—supports achieving an overall replete status linked to multiple health domains.

PubMed ID: 32360596

Large randomized trial showing robust rises in 25(OH)D with supplementation and identification of response modifiers—supports overall status improvement.

PubMed ID: 24139824

Well-conducted RCT in children showing vitamin D fortification reliably raised 25(OH)D—improves nutritional status and overall wellness.

PubMed ID: 26481332

School-based fish/fish‑oil feeding in deficient children produced meaningful 25OHD increases—population nutritional benefit.

PubMed ID: 33339438

Maternal multinutrient supplement increased maternal vitamin D and breast milk DHA—supports maternal/infant nutritional status and wellness.

PubMed ID: 38051700

Large randomized preconception→pregnancy supplement (incl. 10 µg vitamin D/day) substantially raised maternal 25(OH)D and cut deficiency prevalence—clear population-level wellness effect.

PubMed ID: 22170363

Visceral fat loss with Ca+D fortified OJ indicates metabolic/wellness benefit.

PubMed ID: 31049877

Attenuation of IL‑6 and improved nutritional markers with a vitamin D‑containing supplement suggest multi‑domain wellness gains.

PubMed ID: 31278117

Functional and muscle mass improvements during rehab imply broad wellness benefits from multi‑nutrient supplement including vitamin D.

PubMed ID: 31338563

Improved vitamin D status, suppressed PTH and small BMD/muscle‑related benefits in older adults—broad wellness implications.

PubMed ID: 33067129

Fortified yogurt (HMB+vitD/C) improved strength, gait and prevented CRP rise—multi‑ingredient but suggests improved overall function/wellness in elders.

PubMed ID: 1729617

Large fracture‑prevention trial with calcitriol indicates substantial clinical benefit to affected patients, contributing to overall wellness.

PubMed ID: 8172088

Large single dose substantially raised 25(OH)D and modestly reduced PTH in older adults—supports overall nutritional status.

PubMed ID: 8074071

Intermittent high doses produced large 25(OH)D increases (with safety concerns at highest dose)—potent influence on vitamin D status.

PubMed ID: 8593549

Vitamin D‑fortified milk halved winter 25(OH)D decline in adults—meaningful maintenance of vitamin D status relevant to general wellness.

PubMed ID: 9026268

1α‑OH D3 improved BMD and reduced fractures — contributes to overall health.

PubMed ID: 9278463

Supplementation reduced fractures and preserved BMD in older adults — likely contributes to overall wellness.

PubMed ID: 9797910

Ca + vitamin D improved spine BMD and calcium handling in early postmenopausal women — supports broad health.

PubMed ID: 9718191

Short-course oral D3 or UV-B corrected severe deficiency and lowered PTH in very elderly—useful for overall health restoration in deficient individuals.

PubMed ID: 9504953

Fortified milk trial in elderly shows safe and effective correction of deficiency over 1 year, supporting an overall wellness benefit in deficient populations.

PubMed ID: 9797906

Dose–response evidence that oral vitamin D reliably raises 25(OH)D—fundamental for broad wellness claims tied to correcting deficiency.

PubMed ID: 11157326

Dose-dependent restoration of 25(OH)D with no hypercalcemia supports safe correction of deficiency, a general wellness benefit.

PubMed ID: 11991447

Ca+vitamin D improved vitamin D status, normalized PTH and prevented hip bone loss in elderly institutionalized women—broad wellness impact.

PubMed ID: 12568412

800 IU vitamin D + calcium in elderly care residents improved muscle function and halved falls — meaningful functional/wellness benefits.

PubMed ID: 12913194

Sunlight intervention raised vitamin D, improved BMD and reduced hip fractures in institutionalized stroke patients—broad clinical benefit.

PubMed ID: 15260882

Dose comparison (4000 vs 600 IU) showed greater improvements in self‑reported wellbeing with the higher dose.

PubMed ID: 19861511

Vitamin D (800 IU) produced biologic changes in colon mucosa (p21) indicating systemic beneficial cellular effects consistent with overall wellness.

PubMed ID: 20516268

800 IU/day reliably increased 25(OH)D and helped many reach sufficiency—meaningful general health benefit for older adults.

PubMed ID: 19185400

Vitamin D3 improved vitamin D status and lowered iPTH in elderly women with CKD—clinically relevant improvements supporting general health.

PubMed ID: 19244376

Very large biochemical correction of deficiency with resulting PTH reduction and BMD gains in nursing‑home residents—broadly supports overall health in this frail group.

PubMed ID: 19297462

Trial provides clear, actionable intake levels to maintain serum 25(OH)D for most older adults—broadly applicable to overall health.

PubMed ID: 20799973

Community program doubled appropriate vitamin D uptake — evidence for population‑level wellness promotion via increased supplement use (process outcome).

PubMed ID: 20565345

Both high‑dose short-course and low‑dose regimens safely normalized 25(OH)D — meaningful for overall vitamin D repletion and general wellness.

PubMed ID: 20593151

Infant bolus dosing achieved adequate vitamin D status safely — relevant to infant wellness and prevention of deficiency disorders.

PubMed ID: 20308769

Schoolgirl supplementation substantially raised 25(OH)D in a deficient population — broad nutritional/health relevance.

PubMed ID: 20427425

High‑dose IM vitamin D corrected deficiency and produced sustained clinical and radiographic improvement — clear individual wellness benefit.

PubMed ID: 21880848

Large RCT reanalysis found reduced total and breast cancer in non‑supplement users taking Ca+D — meaningful population‑level wellness implication.

PubMed ID: 21556746

Single megadose corrected deficiency, lowered PTH and produced rapid improvements in mobility, pain and quality of life.

PubMed ID: 21288233

Direct randomized supplementation corrected deficiency in elderly safely — general wellness implication.

PubMed ID: 22174164

Quarterly high-dose D3 raised serum 25(OH)D dose‑dependently in adolescent girls with no safety signal—improves vitamin D status relevant to general wellness.

PubMed ID: 22237061

Very‑high‑dose weekly D3 rapidly normalized deficiency in dialysis patients safely—strong evidence for repletion improving vitamin D status and wellness surrogates.

PubMed ID: 23556437

Daily 400 IU D2 or D3 changed vitamin D metabolites with D3 producing larger 25(OH)D increases—biochemical wellness signal.

PubMed ID: 23595003

Dosing schedules clearly raised serum 25‑OH‑D and showed safety limits—demonstrates ability to boost vitamin D status.

PubMed ID: 23460234

Fortified milk trial safely improved 25(OH)D in children—population‑level wellness benefit.

PubMed ID: 23988791

Tailored cholecalciferol restored levels in HD patients—biochemical correction even without immune changes.

PubMed ID: 23564348

Single large IM dose produced sustained sufficiency—strong status improvement, general wellness implication.

PubMed ID: 24344104

Pregnancy dosing increased maternal/infant 25(OH)D and infant sufficiency—broad wellness implication for mother/infant.

PubMed ID: 23585346

1000 IU/day increased 25(OH)D and attenuated hip bone loss—clinically meaningful status and skeletal wellness benefit.

PubMed ID: 24695896

Winter RCT in older adults increased 25(OH)D and changed vitamin D catabolism markers — supports systemic correction of insufficiency.

PubMed ID: 23761326

Large dose‑response trial demonstrated reliable, dose‑dependent increases in serum 25(OH)D across races—broad physiological relevance to wellness.

PubMed ID: 24714660

In pregnancy, 2,000 IU/day reliably achieved maternal and infant sufficiency, a broad contributor to neonatal and maternal wellness.

PubMed ID: 26037521

Daily 20 μg D3 in winter nearly doubled 25(OH)D and normalized levels in most participants—broad biochemical benefit.

PubMed ID: 26100413

Monthly vitamin D dosing improved adherence and was easier for patients—practical benefit for overall supplement effectiveness.

PubMed ID: 26280790

Dose-dependent absorption from fortified food, large 25(OH)D increases at high dose and PTH lowering—demonstrates effective repletion strategy and safety.

PubMed ID: 26416936

High maternal dosing safely raised maternal and infant 25(OH)D, offering a practical route to ensure infant vitamin D status (overall wellness of mother/infant).

PubMed ID: 26160254

12-month high-dose D3 safely and effectively raised 25(OH)D in HIV-infected youth with no safety signals—practical wellness effect.

PubMed ID: 25899914

Rapidly and safely normalized 25(OH)D in frail nursing‑home residents—broad relevance to overall wellness in deficient older adults.

PubMed ID: 26186566

Single IM dose rapidly corrected deficiency in critically ill patients with favorable biomarker changes (PTH, cathelicidin, reduced inflammatory markers)—supports general physiologic benefits.

PubMed ID: 26704923

High-dose vitamin D after sleeve gastrectomy reliably corrected deficiency — restoring sufficiency is a general wellness benefit.

PubMed ID: 27927221

Children/adolescents regimen producing sustained sufficiency over 12 months — strong practical evidence for maintaining vitamin D status (overall wellness).

PubMed ID: 27655438

Adolescent dose-response RCT quantified intakes to maintain cutoffs over winter — practical guidance for maintaining sufficiency.

PubMed ID: 27194308

Dose-dependent increases in total and free 25(OH)D in adults with diabetes demonstrate reproducible repletion strategies (wellness effect).

PubMed ID: 27670154

Neonatal bolus produced rapid, safe repletion vs daily 400 IU — useful repletion strategy for infant wellness.

PubMed ID: 26782853

Elderly dose–response study shows reliable normalization of 25(OH)D in very old adults — improves key wellness biomarkers.

PubMed ID: 27029707

Tailored high‑dose plan restored normal vitamin D in early breast cancer patients safely — relevant to general wellness in that group.

PubMed ID: 27986983

Large randomized dose trial normalized 25(OH)D for most participants and lowered PTH — broad biomarker improvement consistent with overall wellness.

PubMed ID: 27149055

In preterm infants, higher daily vitamin D greatly reduced insufficiency at term — strong overall health/wellness implication in neonates.

PubMed ID: 27676085

ER calcifediol reliably normalized 25(OH)D and lowered iPTH in CKD; meaningful clinical biomarker improvements for patient wellness.

PubMed ID: 26852398

High‑dose IM cholecalciferol and UVB raised and sustained 25(OH)D over winter in gastric bypass patients — improved vitamin D status supports general wellness.

PubMed ID: 28350929

Large RCT raising 25(OH)D with a trend toward lower cancer incidence and improved vitamin D status — broad wellness implication.

PubMed ID: 29084522

High-dose vitamin D improved cardiac biomarkers and QOL in heart-failure patients — notable overall wellness signal.

PubMed ID: 27768857

Large RCT showing substantial repletion and PTH lowering — biochemical restoration likely contributes to overall health/wellness.

PubMed ID: 28346569

Safe, rapid correction of deficiency in frail older adults provides a practical route to improve vitamin D-related health parameters.

PubMed ID: 29676968

Two‑year fortified-milk RCT improved vitamin D status, bone density, and metabolic markers—broad benefits relevant to overall wellness.

PubMed ID: 30843501

Large RCT in deficient children: robust 25(OH)D repletion and reduced secondary hyperparathyroidism—broad wellness implications.

PubMed ID: 32915638

Postpartum 6,400 IU/day safely achieved maternal vitamin D sufficiency across feeding types—meaningful overall health benefit via restoring status.

PubMed ID: 34470599

Infant RCT preventing deficiency likely supports overall infant health and development—strong public health implication.

PubMed ID: 34511168

Alfacalcidol improved immune markers and reduced recurrence/complications in HSP—translates into overall clinical benefit.

PubMed ID: 36029489

Vitamin D3 produced favorable anti-inflammatory and antioxidant changes in ESRD patients, improving physiologic markers linked to health.

PubMed ID: 36364809

Personalized loading + maintenance corrected deficiency quickly and safely—directly improves vitamin D status, a contributor to general wellness.

PubMed ID: 35728797

800 IU/day in extremely preterm infants rapidly corrected deficiency—improving a key micronutrient status tied to general infant health.

PubMed ID: 36141627

Nutritionally complete supplement increased weight and vitamin D/calcium intake in at-risk adults—broad nutritional/wellness benefit.

PubMed ID: 35538377

Dosing regimen study identified practical ways to maintain 25(OH)D with D2 weekly dosing—supports sustained vitamin D status and wellness.

PubMed ID: 36356037

Dose-dependent increases in 25(OH)D in reproductive-age women (esp. 4,000 IU) demonstrate predictable supplementation effects on vitamin D status.

PubMed ID: 36336861

Single high oral dose rapidly increased multiple vitamin D metabolites in elderly without hypercalcemia, demonstrating robust biochemical repletion.

PubMed ID: 36014837

Monthly high‑dose repletion produced marked 25(OH)D increases and favorable biomarker changes—supports clinically meaningful status improvement.

PubMed ID: 37192500

In infants both daily and monthly dosing normalized 25(OH)D; daily dosing produced higher levels—clear evidence that supplementation raises status.

PubMed ID: 36648947

Large randomized VITAL biomarker analysis: vitamin D3 2,000 IU/d reliably raised total, free and bioavailable 25(OH)D, a fundamental 'wellness' biomarker effect.

PubMed ID: 37182754

Higher-intensity loading regimen produced faster, larger increases in 25(OH)D safely—practical evidence for effective repletion.

PubMed ID: 37735799

One month of 1,000 IU/d in winter corrected deficiency and lowered PTH—biochemical improvement relevant to overall wellness, though short-term and no fitness gains.

PubMed ID: 38589121

Clinical improvements in TB patients (weight, oxygenation, inflammatory markers) support an overall health benefit.

PubMed ID: 37811573

Large RCT showing consistent correction of vitamin D deficiency across BMI strata—clear overall status improvement.

PubMed ID: 39138889

Two practical pediatric repletion regimens safely and effectively corrected deficiency—direct wellness application.

PubMed ID: 39125374

ONS containing vitamin D increased serum 25(OH)D and improved nutritional biomarkers in older adults—multi‑domain wellness gains (combined product).

PubMed ID: 40154078

Fortified nutritional supplement increased calorie/protein intake and serum vitamin D, with downstream weight/muscle improvements—broad wellness effect.

PubMed ID: 40203301

mHealth coaching greatly increased vitamin D supplement use in pregnant women (behavioral wellness improvement), though blood levels did not improve in subset.

PubMed ID: 16968578

Adding cholecalciferol reliably raised 25OHD and prevented very low levels — supports a general wellness role by correcting deficiency.

PubMed ID: 19390750

Dose-dependent increases in 25(OH)D and modest PTH reductions in frail elderly — meaningful status improvements relevant to general health.

PubMed ID: 21521310

Cholecalciferol + risedronate substantially raised 25(OH)D and mitigated PTH rise — improved vitamin D status likely benefits overall physiology.

PubMed ID: 35063214

1000 IU/day reliably raised serum 25(OH)D whether tablet or fortified oil — supports routine supplementation for status improvement.

PubMed ID: 37949432

Multidomain trial raising vitamin D linked to improved intrinsic capacity (locomotion and cognition), representing an overall functional wellness improvement.

PubMed ID: 25431880

Salmon intake improved HRV, lowered heart rate and reduced state‑anxiety — multi‑nutrient wellness signal including vitamin D.

PubMed ID: 35527651

Primary‑care children using a multicomponent supplement (includes vitamin D3) had fewer/shorter infections and reduced caregiver‑reported severity—practical wellness benefit though not vitamin D‑specific.

PubMed ID: 18043700

Multivitamin including vitamin D raised 25(OH)D and improved bone‑quality measures in elderly residents — broad wellness benefit in that population.

PubMed ID: 20412605

MM in pregnancy improved maternal nutrient markers including 25(OH)D and reduced SGA in compliant group — general wellness signal.

PubMed ID: 31006806

Antenatal MM modestly raised maternal 25(OH)D in a large trial — supports improved maternal nutritional status (overall wellness).

PubMed ID: 32844185

Antenatal MM increased cord 25(OH)D and other micronutrients — measurable wellness/nutritional improvement for neonates attributable in part to vitamin D.

PubMed ID: 35082139

Large RCT showing decreased incident autoimmune disease suggests a meaningful overall health benefit.

PubMed ID: 35899748

VITAL autoimmune result supports an overall wellness improvement via reduced autoimmune disease incidence.

PubMed ID: 31464392

Micronutrient pack with vitamin D increased 25(OH)D and improved multiple antioxidant biomarkers in older adults—broad wellness indicators.

PubMed ID: 32519507

Hemodialysis RCT showed improved antioxidant enzyme activity and reduced MDA—general health biomarkers improved with vitamin D.

PubMed ID: 35403296

T2DM RCT produced sizeable improvements in glutathione and lowered inflammatory markers—supports overall biological wellness.

PubMed ID: 33268143

ONS trial improved survival/weight/function composite and vitamin D status—meaningful overall wellness outcomes in frail older adults.

PubMed ID: 24317556

Fortified milk modestly improved 25OHD and blood pressure—measurable health improvements from vitamin D fortification.

PubMed ID: 27418034

Fortified cereal maintained vitamin D status in adolescents—nutritional maintenance supporting general wellness.

PubMed ID: 28052885

Fortified formula produced clinically meaningful increases in 25(OH)D and reduced deficiency in young children (general wellness marker).

PubMed ID: 30281106

Growing-up milk significantly raised 25(OH)D and reduced iron deficiency prevalence — broad wellness impact in toddlers.

PubMed ID: 34473420

Duplicate noted above: strong combined‑supplement wellness outcomes (mood, sleep) in deficient prediabetic women.

PubMed ID: 36591342

Large trial demonstrates reliable biochemical increases in 25(OH)D and modest PTH lowering—consistent improvement in vitamin D status that underpins wellness.

PubMed ID: 40195344

Fortified probiotic yogurt significantly increased 25(OH)D and antioxidant capacity in pregnant women—meaningful overall-health effects in this population.

PubMed ID: 1578308

Infant vitamin D dosing prevented rickets and raised 25‑OHD—contributes to overall infant health/wellness.

PubMed ID: 1427127

Improved vitamin D status in institutionalized elderly (supports multiple wellness domains) though no broad clinical endpoints measured.

PubMed ID: 7594162

Improved functional status in vitamin D‑deficient frail elders suggests a broader wellness benefit from correcting deficiency.

PubMed ID: 9771862

D3 is more effective than D2 at raising 25(OH)D — improving vitamin D status can contribute to general wellness.

PubMed ID: 15377355

Improved QoL reported with topical calcipotriol+steroid suggests an overall wellness benefit for psoriasis patients.

PubMed ID: 17031013

Dose-dependent serum 25-OHD increases in elderly women support general physiological benefit potential.

PubMed ID: 18231120

Providing free 400 IU/day to infants markedly improved infant and cord 25(OH)D—population‑health/wellness benefit in immigrant infants.

PubMed ID: 18326598

Cross‑sectional study documenting common insufficiency and demographic risk factors—useful for public‑health wellness planning.

PubMed ID: 18513233

Suberythemal UVB exposures raised 25(OH)D within days—demonstrates rapid status correction though with skin adverse events.

PubMed ID: 18567762

Fortified foods and supplements raised serum 25(OH)D and lowered PTH — clear systemic biochemical benefit.

PubMed ID: 19064513

Well‑powered winter dosing RCT provides quantitative intake recommendations to maintain 25(OH)D thresholds — strong public‑health evidence for status maintenance (overall wellness).

PubMed ID: 18653426

Pharmacist education increased intake and sufficiency and lowered PTH — practical intervention improving status and related health markers.

PubMed ID: 18326608

Single 100,000 IU cholecalciferol safely and substantially raised 25(OH)D for months (status correction supports general wellness).

PubMed ID: 19225122

Daily supplementation (1000–2000 IU) produced substantial, dose‑dependent increases in serum 25(OH)D in isolated Antarctic participants — clear repletion effect.

PubMed ID: 19336509

Weekly D3 markedly corrected deficiency in CF patients (100% reached >30 ng/mL), improving a core biomarker of wellness.

PubMed ID: 19158226

Daily 20 µg D3 in winter produced clear, clinically meaningful increases in 25(OH)D and achieved target levels in most participants.

PubMed ID: 21177785

D3 raised and maintained serum and tissue 25(OH)D much more than D2 — practical relevance for effective supplementation and general wellness.

PubMed ID: 20683712

Oral supplementation corrected deficiency and lowered PTH reliably vs sun advice — supports general health via correcting deficiency.

PubMed ID: 20458090

Higher-dose vitamin D after hip fracture significantly reduced hospital readmissions over 12 months — meaningful overall health benefit in elderly patients.

PubMed ID: 21224868

Long-term fortified dairy supplementation maintained 25(OH)D and greatly reduced prevalence of winter insufficiency—broad wellness relevance.

PubMed ID: 21574782

Improved adherence to infant vitamin D supplementation via filmstrip supports better real-world effectiveness and overall wellness.

PubMed ID: 22908115

Significant reduction in ARIs in children and clear repletion supports general wellness improvements.

PubMed ID: 23066119

Pilot in older adults produced clear dose‑response increases in 25(OH)D—improved biochemical status that underpins broad wellness claims.

PubMed ID: 22613271

Single megadose rapidly corrected deficiency and improved physical performance—broad functional wellness effects.

PubMed ID: 22933542

Monthly 50,000 IU safely corrected deficiency in most HIV-infected youth—clear status/overall benefit.

PubMed ID: 23783292

Fortification trial prevented winter declines and deficiency, a clear population‑level wellness benefit by maintaining adequate 25(OH)D.

PubMed ID: 23632722

Clear RCT dose-response raising infant 25(OH)D and improving status—broad wellness relevance for infants.

PubMed ID: 24290111

Maternal dosing reliably raised breast-milk vitamin D and converted infants to sufficient status—practical wellness benefit.

PubMed ID: 23851699

Fortified milk preventing winter decline in children supports sustained vitamin D status and population wellness.

PubMed ID: 23506383

Screening study showed high prevalence of undiagnosed glucose dysregulation and ~31% had vitamin D deficiency — highlights public health relevance of vitamin D status.

PubMed ID: 26151178

Randomized dose-response study showed graded, safe increases in 25(OH)D — providing a practical basis for achieving replete status associated with multiple health outcomes.

PubMed ID: 25971439

Observational hemodialysis data: higher vitamin D strongly associated with fewer infections, cardiac events and markedly lower mortality—suggests broad wellness benefit in that population.

PubMed ID: 25988278

Lower disease activity and fatigue in juvenile SLE indicates meaningful overall health improvement.

PubMed ID: 27189286

Demonstrates effective, rapid repletion in postmenopausal women (biochemical correction linked to broad wellness implications).

PubMed ID: 27733403

Dose‑response trial in children showed clear, predictable increases in 25(OH)D—useful population‑level evidence for maintaining overall vitamin D sufficiency.

PubMed ID: 27460266

2200 IU/day reliably corrected deficiency in athletes, producing biochemical sufficiency that supports general wellness.

PubMed ID: 28679555

Well‑powered RCT showing D3 more effective than D2 at raising 25(OH)D—supports effective repletion for general health.

PubMed ID: 28231782

Large RCT comparing dosing schedules/forms showed D3 regimens produced higher sustained 25(OH)D—practical guidance for wellness repletion.

PubMed ID: 28976265

Fortified foods produced predictable increases in 25OHD in menopausal women—supports population‑level vitamin D status improvement.

PubMed ID: 28054964

800 IU/day produced far greater attainment of sufficiency versus 200 IU/day—reliable status improvement underpinning general wellness.

PubMed ID: 29029097

Large schoolchildren RCT showed 2000 IU/day reliably raised 25(OH)D and reduced deficiency — broad public-health wellness relevance.

PubMed ID: 29903095

Adolescents receiving 800 IU/day significantly increased 25(OH)D and reduced deficiency prevalence—biomarker change supportive of general wellness.

PubMed ID: 29788364

Large prenatal screening program produced big increases in maternal 25(OH)D and large reductions in preeclampsia and gestational diabetes — substantial wellness impact in pregnancy.

PubMed ID: 30583032

Pre‑diabetes RCT showed improved insulin resistance and dramatic reduction in diabetes progression — major wellness/clinical benefit.

PubMed ID: 29550150

Higher‑dose vitamin D in pregnancy raised 25(OH)D and reduced pre‑eclampsia and SGA, supporting maternal/offspring wellness.

PubMed ID: 29722846

In malnourished children vitamin D improved growth z‑scores and decreased developmental delays — broad wellness benefits.

PubMed ID: 29661746

Monthly dosing improved multiple markers (PTH, CRP, kidney markers) vs intermittent dosing — broad biochemical benefits.

PubMed ID: 30021811

Cord‑blood 25(OH)D associations with reduced infant wheeze and immune signatures imply important early‑life wellness effects.

PubMed ID: 30852657

Population-level fortification produced large, clinically meaningful increases in 25(OH)D and reduced deficiency.

PubMed ID: 30395842

IM dosing improved mood/sexual function and 25(OH)D quickly in deficient women—clinically meaningful wellness effects.

PubMed ID: 31344685

Significant improvements in insulin sensitivity and β-cell function with 5000 IU/day in at-risk adults suggest meaningful metabolic/wellness benefits.

PubMed ID: 31624297

Improved antioxidant capacity and symptom scores (PMS) alongside corrected deficiency indicate broader wellness benefits for symptomatic deficient individuals.

PubMed ID: 31548595

Capsule and sublingual formulations raised 25(OH)D similarly and reliably—demonstrates consistent biochemical repletion that can support general wellness.

PubMed ID: 30898175

Micellised formulation produced larger 25(OH)D increases and PTH decline without toxicity—robust improvement in vitamin D status relevant to overall health.

PubMed ID: 31652554

Post‑hoc subgroup showed marked survival improvements in poorly differentiated digestive adenocarcinoma (exploratory, large effect in subgroup).

PubMed ID: 30773722

Reduced fungal infections and shorter PICU stays in children imply substantial clinical overall benefit.

PubMed ID: 31486158

In ventilated trauma patients vitamin D repletion improved inflammatory markers and clinically meaningful outcomes (ventilator/ICU days).

PubMed ID: 30964527

High‑dose vitamin D3 increased 25(OH)D and produced a suggestive (though not definitive) progression‑free survival benefit in CRC patients.

PubMed ID: 33396551

Breast cancer survivors in a lifestyle program including vitamin D reported improved QoL and fewer symptoms; vitamin D correlated with symptom improvements.

PubMed ID: 32653031

RCT showed monthly solid dosing improved adherence and raised 25(OH)D in most participants—practical benefit for achieving wellness levels.

PubMed ID: 32103645

Oral vitamin D produced greater short‑term increases in 25(OH)D than sunlight exposure—improves biochemical status.

PubMed ID: 33154023

Asthma trial showed improved disease control and quality of life with vitamin D supplementation.

PubMed ID: 32507538

High‑dose vitamin D improved pain, fatigue, physical performance and PROMIS QoL measures in children (multidomain wellbeing gains).

PubMed ID: 33087250

Metabolomic and outcome correlations in critically ill patients whose 25(OH)D rose suggest broad systemic benefit.

PubMed ID: 31897949

Reduced migraine days and attack duration with vitamin D is a clinically meaningful improvement in patient well-being.

PubMed ID: 33787584

Pneumonia trial produced major clinical improvements and restored 25(OH)D — strong single‑condition wellness benefit.

PubMed ID: 34392411

4000 IU/day in CKD children achieved sufficiency in most participants without toxicity — robust biochemical wellness signal.

PubMed ID: 34689128

Large improvements in VO2max and strength after 60 days suggest meaningful functional wellness gains.

PubMed ID: 33481482

Reduced URTI burden and achieved sufficiency in recruits — meaningful clinical wellness benefit.

PubMed ID: 34128826

Dose‑dependent increases in total and free 25OHD in children support improved overall vitamin D status (repeated entry for emphasis on repletion).

PubMed ID: 34548526

Individualized loading safe and more effective than monthly dosing — enhances ability to achieve sufficiency (repeated supportive entry).

PubMed ID: 33875811

Stoss dosing achieved rapid repletion and higher adequacy rates—restoring sufficiency is a broad wellness benefit in deficient patients.

PubMed ID: 34017029

High‑dose vitamin D produced large biochemical and anti‑inflammatory changes in COVID patients—supports a general wellness/biologic benefit signal.

PubMed ID: 34550329

Dose‑dependent increases in 25(OH)D in children with some small lipid improvements—general wellness biomarker improvement.

PubMed ID: 36333692

Substantial symptomatic and QoL improvements in SUI point to meaningful overall wellness benefit for affected women.

PubMed ID: 36527143

100k IU bolus + weekly 10k IU rapidly and safely raised 25(OH)D and made most participants sufficient—meaningful overall nutritional/health improvement.

PubMed ID: 35276963

4000 IU/day produced large increases in 25‑OHD in advanced cancer patients—restoring vitamin D status is broadly supportive of wellness.

PubMed ID: 37380191

Large trial showing modest reductions in MI and major CV events suggests a population‑level wellness benefit.

PubMed ID: 37375660

Reliable repletion in toddlers reduces deficiency prevalence, supporting general health and wellness.

PubMed ID: 37926939

Dose‑finding study achieved serum targets safely in a high‑risk pediatric group, enabling potential wellness benefits via repletion.

PubMed ID: 37892510

Daily 5000 IU in hospital staff associated with fewer hospitalizations/ICU/ER visits, implying broad health benefit.

PubMed ID: 39557774

Significant, clinically meaningful improvements in QoL in colorectal cancer patients receiving vitamin D.

PubMed ID: 38729818

Lower 30‑day mortality among those reaching adequate 25(OH)D suggests broad outcome benefit.

PubMed ID: 38310218

Large pregnancy trial showed multiple clinical benefits (preeclampsia, preterm, low birthweight).

PubMed ID: 39861434

Long‑COVID symptom reduction and biomarker improvements indicate a meaningful overall wellness gain (VD3+K2).

PubMed ID: 40310565

Fewer respiratory infection and fever days imply tangible wellness benefits in children.

PubMed ID: 40005002

Reliable restoration of 25(OH)D in deficient people supports general physiological restoration.

PubMed ID: 40229998

Strong association with higher pathologic complete response during neoadjuvant chemo—clinically meaningful outcome that can translate to overall patient benefit.

PubMed ID: 40750396

Safe and clinically meaningful increase in serum 25(OH)D via UVB suggests an overall improvement in vitamin D status.

PubMed ID: 41485966

Comprehensive nutritional rehab including vitamin D improved multiple domains (muscle, cognition, QoL) — overall wellness benefit.

PubMed ID: 40114038

Shows that genetic differences markedly alter 25‑OH D response to supplementation—important for achieving wellness targets through vitamin D.

PubMed ID: 41683343

Intervention including vitamin D produced substantial symptom improvement in post‑COVID ME/CFS, suggesting broader wellness gains.

PubMed ID: 33382385

Allergic rhinitis RCT showed reduced IL‑4 and eosinophils with vitamin D adjunct—supports immune modulation.

PubMed ID: 33154023

RCT in vitamin D‑deficient asthmatics showed improved control/QOL, consistent with immune-mediated airway benefits.

PubMed ID: 32830462

High-dose vitamin D altered T-cell N-glycan branching in MS patients, a direct immune-modulatory effect.

PubMed ID: 32867053

Winter vitamin D supplementation restored airway surface liquid antimicrobial activity (improved innate airway defense).

PubMed ID: 32871238

Calcifediol treatment in COVID-19 associated with markedly fewer ICU admissions, consistent with immune/host-response benefit.

PubMed ID: 32043288

Vitamin D3 + DPP‑4 inhibitor preserved C‑peptide in LADA, suggesting immune/autoimmunity modulation.

PubMed ID: 33302570

RCT: oral 25‑OH‑D3 reduced URTI events and symptom severity, consistent with immune benefit.

PubMed ID: 33266022

High‑dose vitamin D lowered mucosal proinflammatory cytokines in Crohn's tissue (immune modulation).

PubMed ID: 33339609

Alfacalcidol periop reduced postoperative infections, implying immune/host‑defense effect of active vitamin D.

PubMed ID: 32122449

Lower 25‑OH‑D associated with higher IgE and worse asthma severity (immune‑related correlation).

PubMed ID: 33787584

High‑dose D3 in children with pneumonia reduced mortality and improved oxygenation — strong immune/clinical effect.

PubMed ID: 33481482

RCT in military recruits: restoring vitamin D sufficiency reduced URTI incidence/severity — direct immune benefit.

PubMed ID: 33060436

Children with IBD: vitamin D improved disease activity and decreased multiple inflammatory/immune cytokines.

PubMed ID: 34653608

Calcifediol raised 25(OH)D rapidly and improved NLR/lymphocyte% in hospitalized COVID patients — direct immune marker improvement.

PubMed ID: 34165010

Very low admission 25(OH)D in ARDS associated with worse ventilator duration and higher mortality — observational link to immune/critical‑illness outcomes.

PubMed ID: 34262557

Low‑dose daily vitamin D attenuated seasonal T‑cell IFN‑γ rises (modulation of cellular immune response).

PubMed ID: 34280356

Weekly high‑dose vitamin D normalized 25OHD and produced a modest CD4+ T‑cell increase in people with HIV (direct immune marker change).

PubMed ID: 34166843

Prenatal vitamin D sufficiency associated with reduced allergic rhinitis with aeroallergen sensitization in offspring—immune/allergic outcome.

PubMed ID: 34017029

High‑dose daily vitamin D in COVID-19 produced large reductions in inflammatory markers (CRP, IL‑6) implying immunomodulation.

PubMed ID: 34521593

Adjunct vitamin D3 increased H. pylori eradication, suggesting enhanced host antimicrobial response.

PubMed ID: 34893133

Calcitriol added to sirolimus improved ITP response and raised active vitamin D—direct immune‑modulating effect.

PubMed ID: 34280843

Vitamin D supplementation entered multivariate models linked to MRI activity in MS (immune‑mediated disease) in observational data.

PubMed ID: 35198149

Adjunct vitamin D in pediatric TB shortened symptoms and improved nutrition—supports infection recovery/host defense.

PubMed ID: 35639792

High loading dose raised 25(OH)D rapidly and was associated with lower 14‑day COVID‑19 mortality after adjustment.

PubMed ID: 35720377

Repletion in T2D reduced platelet activation and multiple proinflammatory/immune mediators—immune modulation.

PubMed ID: 35780325

Large RCT found modest reductions in antibiotic prescriptions, implying fewer infections in those with low baseline vitamin D.

PubMed ID: 35513795

Calcitriol in TB raised CD4 counts and sped microbiologic clearance — direct immune enhancement.

PubMed ID: 35283046

Trend to fewer influenza cases in preschoolers suggests possible infection prevention.

PubMed ID: 35487792

RCT showed marked reduction in SARS‑CoV‑2 infections with 4000 IU/day — strong immune/prophylactic signal.

PubMed ID: 36235575

Dose-dependent rises in 25(OH)D were associated with significant increases in CD3+/CD4+ T‑cell percentages, indicating immunomodulatory effects.

PubMed ID: 36295519

High IM dose in hospitalized COVID patients improved inflammatory markers and clinical improvement, consistent with immune-related benefits in acute illness.

PubMed ID: 36066168

Antenatal vitamin D produced dose-dependent reductions in amniotic NF-κB, an immune/inflammatory marker.

PubMed ID: 36156472

RCT in SLE showed reduced disease activity and corrected deficiency, indicating immune-modulating benefit.

PubMed ID: 35276863

Higher vitamin D dosing raised 25(OH)D and associated with fewer symptomatic SARS‑CoV‑2 infections in healthcare workers.

PubMed ID: 35334923

Maternal vitamin D sufficiency altered infant cytokine responses (lower resting TNF, stronger stimulated TNF/IFNγ) indicating immune modulation.

PubMed ID: 36615837

Daily 5000 IU reduced influenza‑like illnesses in a large randomized pragmatic trial, supporting immune/anti‑infective benefit.

PubMed ID: 35129441

Supplementation in Crohn’s reduced pro‑inflammatory cytokines, indicating immune modulation.

PubMed ID: 35241369

Vitamin D given during anthracycline chemo lowered IL‑6, reflecting immunomodulatory/anti‑inflammatory action.

PubMed ID: 36329227

High‑dose vitamin D in critically ill COVID patients increased NK/NKT counts and reduced CRP by day 7.

PubMed ID: 35468580

High‑dose (10,000 IU/day) increased IFNγ and NK cytotoxicity vs lower dose, showing antiviral/immune activation.

PubMed ID: 38129893

Dose‑dependent increases in TLR‑2/4 expression indicate a direct innate immune effect.

PubMed ID: 37926939

High‑dose regimen in children with asthma achieved anti‑inflammatory serum targets, implying immune modulation potential.

PubMed ID: 37871795

Maternal vitamin D trial linked higher maternal D to fewer offspring respiratory/diarrheal illnesses—supports immune effects in offspring.

PubMed ID: 38264896

RCT in TB patients showed increased MTB‑induced IFN‑γ in low‑D patients and clinical improvements, indicating immune modulation.

PubMed ID: 37198277

Repletion improved tonsil histology and lowered proinflammatory markers, showing direct immunomodulatory benefit.

PubMed ID: 37716008

Adjunctive vitamin D improved allergic rhinitis symptoms and immune markers versus steroid alone.

PubMed ID: 32828116

Higher-dose vitamin D improved chronic urticaria symptoms and raised 25(OH)D, consistent with immune-mediated skin benefit.

PubMed ID: 36606379

Intralesional vitamin D3 produced modest wart clearance, implying local immune activation.

PubMed ID: 37892436

Post‑hoc RCT subgroup showed improved relapse‑free survival in CRC with vitamin D in patients with high sCD40L, consistent with immune‑mediated effect.

PubMed ID: 36889512

Calcifediol around COVID vaccination increased SARS‑CoV‑2 T‑cell proliferation and anti‑inflammatory cytokines and reduced probable COVID cases—direct immune benefit.

PubMed ID: 38706151

Raised antimicrobial peptide (LL-37) and improved infection biomarkers/SOFA in septic patients → direct immune effect.

PubMed ID: 38291897

Very high single dose in severe COVID rapidly raised 25(OH)D and improved organ‑failure and mortality → strong immune/host‑defense implication.

PubMed ID: 39298119

Symptomatic improvement in allergic rhinitis with concomitant 25(OH)D rise suggests immunomodulatory benefit in atopic disease.

PubMed ID: 38479439

Dose‑dependent modulation of immune‑cell transcriptome with downregulated pro‑inflammatory pathways and upregulated antigen/antiviral genes.

PubMed ID: 39020381

RCT showed reduced IFN-γ and clinical symptom improvement in immune-mediated oral lichen planus.

PubMed ID: 38982373

EPTB trial: corrected deficiency with better weight, Hb and lowered CRP/ESR implying immune/nutritional benefit.

PubMed ID: 39543837

Increased regulatory T cells and higher pregnancy success indicate immune modulation.

PubMed ID: 38441899

New-onset T1D: ergocalciferol slowed β-cell decline, consistent with immunomodulatory effect.

PubMed ID: 38729818

ICU trial: higher achieved 25(OH)D linked to markedly lower 30-day mortality, suggesting immune/host-response benefit.

PubMed ID: 39861434

VD3+K2 lowered long‑COVID symptom burden and inflammatory markers, implying immune modulation.

PubMed ID: 40924491

Active vitamin D altered monocyte immune gene expression in critically ill patients.

PubMed ID: 40310565

Daily vitamin D reduced ARTI and fever days in children, supporting immune protection.

PubMed ID: 40742303

High‑dose D in new‑onset type 1 diabetes preserved β‑cell function (autoimmune disease), indicating immune modulation.

PubMed ID: 40646117

In Parkinson’s patients, vitamin D shifted T cell balance (↓Th17, ↑Treg), a direct immune effect.

PubMed ID: 40818016

Severe SLE trial showed larger rises in 25OHD and hints of serologic improvement (complement), suggesting immune impact.

PubMed ID: 40996174

Adjunct vitamin D in Kawasaki disease shortened fever and lowered inflammatory cytokines — direct immune‑modulating effect.

PubMed ID: 40139536

High‑dose vitamin D altered maternal IL‑1β (an immune cytokine) in pregnancy — selective immunomodulation.

PubMed ID: 41525115

High‑dose vitamin D in ventilated ICU patients improved clinical scores and survival, consistent with immune/host‑response benefits.

PubMed ID: 26205023

RCT: correcting deficiency markedly increased bacterial vaginosis cure rates (mucosal immune effect).

PubMed ID: 31486158

In vitamin D‑deficient ventilated trauma patients, repletion associated with lower inflammatory markers and shorter ICU stays (immune/inflammation effect).

PubMed ID: 31071734

Reduced anti‑Tg antibodies/TSH in Hashimoto’s indicates immunomodulatory effect on thyroid autoimmunity.

PubMed ID: 30696977

RCT in Hashimoto's showed immunologic shifts (reduced Th17/Tr1), consistent immune-modulating effect.

PubMed ID: 31713184

Calcitriol after transplant sped lymphocyte recovery and improved relapse-free survival—direct immune effect.

PubMed ID: 30895944

Topical vitamin D analogue increased tissue-resident memory T cells with reduced SCC incidence—local immune effect.

PubMed ID: 31570180

Supplementation altered IL-17A/IL-10 ratio in asthmatics, indicating immune modulation linked to lung function.

PubMed ID: 33145984

Vitamin D improved severe atopic dermatitis (EASI) and likely acted through immune pathways.

PubMed ID: 32659891

Lowered CRP and TNF‑α in T2DM patients—systemic immune/inflammatory marker improvements.

PubMed ID: 32783547

In RA patients vitamin D increased regulatory T cells and reduced disease activity, indicating adaptive immune modulation.

PubMed ID: 33184146

High‑dose cholecalciferol in deficient mild COVID‑19 increased viral clearance and lowered fibrinogen, indicating enhanced host antiviral/inflammatory responses.

PubMed ID: 32485124

Single high dose in septic children lowered IL‑6/TNF‑α and reduced shock incidence—supports immune/inflammatory modulation in acute infection.

PubMed ID: 23331510

Adjunctive vitamin D in TB improved MTB-specific IFN-γ responses and clinical recovery, indicating immune benefit.

PubMed ID: 24108783

Monthly high-dose vitamin D associated with fewer antibiotic prescriptions in older adults (subgroup), suggesting reduced infections.

PubMed ID: 24290111

Maternal supplementation raised breast-milk vitamin D and corrected infant deficiency, which can support infant immune function.

PubMed ID: 24716637

RCT: vitamin D added to PEG-IFN/RBV increased early viral (HCV) response—direct antiviral/immune effect signal.

PubMed ID: 23694840

RCT in otitis-prone children: 1000 IU/day reduced acute otitis media incidence—supports infection-related immune benefit.

PubMed ID: 24193954

Pediatric RCT: high‑dose monthly vitamin D reduced asthma exacerbations and steroid need—immune-mediated respiratory benefit.

PubMed ID: 24766747

Lower active vitamin D associated with greater pneumonia severity and longer stays (observational link to immune-related outcomes).

PubMed ID: 25029202

Calcitriol increased leukocyte immune mRNA (cathelicidin, IL-10) in sepsis—mechanistic immunomodulation though no clinical benefit.

PubMed ID: 25135997

Vitamin D deficiency associated with worse lymphoma outcomes and substitution improved rituximab-mediated cytotoxicity (immune mechanism).

PubMed ID: 24885201

RCT showed significantly fewer laboratory-confirmed viral URTIs and lower viral load, directly supporting immune protection.

PubMed ID: 25283480

Randomized trial: higher maternal/infant vitamin D reduced early-childhood ARI visits—direct clinical immune/anti-infective benefit.

PubMed ID: 25476069

RCT in COPD showed fewer exacerbations in vitamin D–deficient subgroup—supports immune/host-defense benefit when deficient.

PubMed ID: 24698320

Low 25(OH)D in children associated with more severe wheeze exacerbations — clinical link between vitamin D status and immune-related respiratory events.

PubMed ID: 25089537

Prenatal vitamin D produced a measurable immune change (LL-37 reduction) in neonatal cells — direct immunologic effect.

PubMed ID: 24572452

Alfacalcidol reduced IL‑6 in obese adults, indicating vitamin D analogue anti‑inflammatory/immune effects in humans.

PubMed ID: 26086941

ICU RCT: high single-dose cholecalciferol raised bioavailable 25(OH)D and antimicrobial peptide LL-37 and reduced proinflammatory cytokines — direct immune activity.

PubMed ID: 26319134

RCT in infection‑prone patients: daily 4000 IU vitamin D reduced number of respiratory infections and delayed first RTI — clinical immune benefit.

PubMed ID: 25946929

Severe COPD trial showed fewer exacerbations and improved lung function — suggests enhanced pulmonary immune/resilience.

PubMed ID: 24988118

RCT in HIV-infected youth: vitamin D raised 25(OH)D and produced modest but significant improvements in viral load and CD4% — direct immune benefit.

PubMed ID: 26371397

Observational HIV cohort: sufficient baseline vitamin D associated with greater CD4 recovery over 18 months (supportive but nonrandomized).

PubMed ID: 25971439

Hemodialysis cohort: higher 25(OH)D associated with substantially fewer infections and infection-related events (observational).

PubMed ID: 25666504

Weekly high-dose vitamin D in MS attenuated rises in EBV antibody titers—suggests an immune effect.

PubMed ID: 26545199

Active vitamin D increased nasal antimicrobial peptides (HNP1-3) and plasma LL‑37 correlated with 25(OH)D—mechanistic immune benefit.

PubMed ID: 25801892

Long-term monthly vitamin D in SLE produced increased regulatory T cells and Th2 shift—direct immunomodulatory evidence.

PubMed ID: 26718578

High-dose vitamin D in MS reduced pro-inflammatory IL-17+ CD4+ and other pathogenic T‑cell subsets—strong immune biomarker changes.

PubMed ID: 27764529

High‑dose cholecalciferol increased regulatory T cells (Tregs) in type 1 diabetes, a direct immune change.

PubMed ID: 27161894

Vitamin D repletion in dialysis patients altered monocyte vitamin D–related proteins and lowered inflammatory markers, implying immune effects.

PubMed ID: 27060679

Maternal+infant vitamin D reduced aeroallergen sensitization and fewer asthma-related visits—strong immunologic/clinical signal.

PubMed ID: 25988278

In juvenile SLE vitamin D repletion lowered disease activity—direct autoimmune/immune-modulating benefit.

PubMed ID: 27861708

RCT showed 40% relative reduction in acute respiratory infections with high‑dose monthly vitamin D—direct immune/anti‑infective benefit.

PubMed ID: 27827962

Cholecalciferol increased serum hCAP‑18 (cathelicidin), an antimicrobial peptide, supporting mechanistic immune enhancement.

PubMed ID: 27184759

Maternal/infant supplementation RCT reduced days with respiratory/diarrhoeal infections in infants—clear clinical immune benefit.

PubMed ID: 27806875

High‑dose vitamin D altered T‑cell cytokine shifts in RRMS, indicating immune‑modulating effects.

PubMed ID: 27655755

Higher pregnancy dose increased regulatory CD4+ T cells, a direct immunologic signal.

PubMed ID: 27711190

Maternal 25(OH)D correlated with large transcriptomic shifts including immune‑related modules.

PubMed ID: 26981576

Low pre‑ART vitamin D associated with higher IRIS risk and immune activation markers in HIV patients.

PubMed ID: 27975236

High‑dose vitamin D in Crohn's showed fewer relapses (per‑protocol) suggesting immunologic/anti‑inflammatory benefit.

PubMed ID: 27357103

5‑year RCT: weekly vitamin D reduced urinary tract infections — randomized clinical evidence of reduced infection risk.

PubMed ID: 27506771

High‑dose prenatal vitamin D altered neonatal cord‑blood cytokine responses — direct immunomodulatory effect.

PubMed ID: 26932169

SLIT+vitamin D improved nasal and asthma symptoms in children—direct immuno‑allergic clinical benefit.

PubMed ID: 28228421

Oral D3 repletion upregulated immune pathway gene expression vs UVB (mechanistic immune signal).

PubMed ID: 28099429

Observational neonatal HIE study found low 25(OH)D and correlations with anti‑inflammatory cytokines, suggesting immune links.

PubMed ID: 28665937

RCT in dialysis patients showed vitamin D modulated lymphocyte TLR/cytokine expression indicating immunomodulatory effects.

PubMed ID: 28376103

In chronic hepatitis C, correcting deficiency reduced IP‑10 and DPP‑IV, biomarkers of immune/inflammatory activation.

PubMed ID: 28552588

Randomized antenatal supplementation produced robust neonatal immune marker changes indicating immune modulation.

PubMed ID: 29248753

Small RCT in ventilator‑associated pneumonia lowered IL‑6 and reduced mortality, indicating immunomodulatory/clinical immune benefit.

PubMed ID: 28161530

Dose‑ranging RCT in HIV‑infected youth raised 25(OH)D and related metabolites—relevant to immune status in immunocompromised hosts.

PubMed ID: 28425575

Reduced hs-CRP and NLR in adolescents indicates anti-inflammatory/immune-modulating effect.

PubMed ID: 29153546

In MS patients vitamin D preserved CD25 measures versus decline in placebo, suggesting immune modulation.

PubMed ID: 28731372

High‑dose D3 reduced anti‑EBNA‑1 antibodies in RRMS, showing a measurable immunologic effect.

PubMed ID: 29861487

RCT in children showed increased lymphocyte % and reduced stimulated IL‑6, indicating immunomodulation.

PubMed ID: 29712666

RCT showed large reduction in respiratory illnesses in children with sickle cell disease, indicating immune/ infection protection.

PubMed ID: 28994661

High‑dose vitamin D lowered T‑cell activation/exhaustion and proinflammatory monocytes in HIV+ youth, a direct immune modulation signal.

PubMed ID: 30333271

Alfacalcidol RCT in frail elderly increased IL‑10 and improved T‑cell ratios, indicating clear immunoregulatory effects.

PubMed ID: 29402723

Calcitriol in asthma increased IL‑10/IFNγ and antimicrobial peptide (LL‑37) — direct immunologic improvements.

PubMed ID: 29303025

Maternal 25(OH)D lower than threshold associated with more infant respiratory/immune events (observational).

PubMed ID: 30021811

Higher cord blood 25(OH)D linked to immune‑gene expression patterns and lower infant wheeze risk (observational).

PubMed ID: 30797266

Adjunctive cholecalciferol reduced TB treatment failure and increased early response—supports immune-mediated anti-mycobacterial effect.

PubMed ID: 30361957

Cholecalciferol adjunct reduced recurrent UTIs—clinical immune/anti-infective signal (non-blinded trial).

PubMed ID: 31335838

Dose-dependent large increase in regulatory T cells in preterm infants, indicating immune modulation.

PubMed ID: 30328294

Large RCT showed ~24% reduction in non-influenza respiratory viral infections—strong immune benefit.

PubMed ID: 30800121

Supplementation lowered inflammatory cytokines (TNFα, IL‑6) in elderly—immune marker changes.

PubMed ID: 30601999

RCT in IBD patients demonstrated fewer clinic-diagnosed URIs, especially if baseline-deficient.

PubMed ID: 31594857

High-dose vitamin D added to interferon in RRMS reduced MRI lesion activity (immune-modulating effect) though clinical endpoints unchanged.

PubMed ID: 31624297

Supplementation reduced inflammatory cytokines (IL-12) and improved antioxidant capacity, indicating immune/inflammatory modulation.

PubMed ID: 31274211

Single high‑dose IM vitamin D in UC patients significantly lowered Th1 pro‑inflammatory cytokines (TNF‑α, IFN‑γ, IL‑12p70).

PubMed ID: 30773722

Randomized trial in critically ill children found oral vitamin D reduced Candida infections, consistent with enhanced host defense.

PubMed ID: 34459959

Histologic improvement included reduced lobular inflammation in children with NAFLD.

PubMed ID: 35067753

Fish oil + vitamin D lowered TNF‑α, indicating immune/inflammatory modulation.

PubMed ID: 37667938

High‑dose vitamin D reduced hs‑CRP and STAT‑3, consistent with immune/inflammatory effects.

PubMed ID: 22215943

Randomized add‑on vitamin D (2,000 IU/d) greatly increased HCV viral clearance—direct immune/antiviral effect.

PubMed ID: 22371640

Small RCT showed higher sustained virologic response with adjunctive vitamin D in HCV genotype 2–3—supports immune potentiation.

PubMed ID: 25778685

Randomized cholecalciferol raised 25(OH)D and improved early antiviral response in HCV (supports immune/antiviral effects).

PubMed ID: 25632203

In children with HCV, vitamin D added to therapy was linked to better early and sustained virologic responses (immune effect).

PubMed ID: 36079732

Multi-ingredient supplement including vitamin D reduced IL-6 and CRP in older hospitalized adults (supports immune/inflammatory modulation; attribution to vitamin D is indirect).

PubMed ID: 26653112

High‑dose vitamin D (4000 IU/day) RCT reduced an ex vivo marker of CD4+ T‑cell activation — strong human immunomodulatory evidence.

PubMed ID: 31049877

Vitamin D‑containing multi‑nutrient product attenuated IL‑6 rise (marker of low‑grade inflammation/immune activation) in older adults.

PubMed ID: 39307095

High‑dose D3 produced metabolomic immune-related changes and lower 180‑day mortality in a specific critically‑ill metabotype.

PubMed ID: 26394045

Adjunct daily vitD increased LL-37 and hastened sputum culture conversion in TB—direct antimicrobial/immune effects.

PubMed ID: 11576883

Paricalcitol (vitamin D analogue) showed a trend toward improved delayed-type hypersensitivity (anergy conversion) in dialysis patients.

PubMed ID: 14708413

IV calcitriol lowered inflammatory cytokines (TNF-α, IL-1, IL-6), implying immune-modulatory effects.

PubMed ID: 16479024

Adjunct high-dose vitamin D significantly improved sputum conversion and radiologic recovery in TB—supports immune-mediated antimicrobial host responses.

PubMed ID: 17578859

Observational MS study links lower vitamin D to higher disease activity (immune-mediated), supporting immune relevance.

PubMed ID: 20427749

High‑dose vitamin D in MS produced large 25(OH)D increases and immunologic changes with fewer relapses (small trial).

PubMed ID: 21724580

Rcts showed vitamin D reduced a composite inflammation score (immune‑related markers) in colorectal adenoma patients.

PubMed ID: 21697250

High-dose cholecalciferol markedly raised 25(OH)D and suppressed MS-associated T-cell responses (direct immunomodulatory effect).

PubMed ID: 22019331

Active vitamin D (calcitriol) reduced proteinuria in IgA nephropathy—consistent with immunomodulatory/anti-inflammatory effects.

PubMed ID: 22442277

RCT in T2D showed reduced inflammatory markers—supports immune/inflammatory modulation.

PubMed ID: 22344966

Vitamin D‑fortified drink RCT reduced multiple inflammation markers, implying immune modulation.

PubMed ID: 23395257

Active vitamin D analogue (alfacalcidol) preserved beta-cell function in new-onset type 1 diabetes, indicating immunomodulatory/autoimmune benefit.

PubMed ID: 23199009

HIV-infected men study showed correlations between calcitriol/cholecalciferol, PTH and T‑cell subsets suggesting immunomodulatory effects.

PubMed ID: 24273887

Calcitriol reduced acute cellular rejection and increased Tregs—direct immune-modulatory effect.

PubMed ID: 23884390

Pregnancy RCT showed reduced hs-CRP and improved antioxidant markers with vitamin D, indicating immune/anti-inflammatory effects.

PubMed ID: 25215557

Vitamin D (±calcium) significantly reduced IL-6 and TNF-α (key immune/inflammatory cytokines).

PubMed ID: 25461390

RCT showed short-term high-dose D increased IFN-γ and IL-10 in deficient subjects, indicating immune modulation.

PubMed ID: 26401986

High-dose D3 increased anti-inflammatory IL-10 in RRMS patients, indicating immunomodulation.

PubMed ID: 26277548

Randomized trial in new-onset T1D showed cholecalciferol markedly improved Treg suppressive capacity, a direct immune-modulating effect.

PubMed ID: 26186566

ICU RCT: single IM vitamin D normalized 25(OH)D and raised antimicrobial peptide (cathelicidin), indicating enhanced innate immune responses.

PubMed ID: 27488327

RCT in ulcerative colitis: single high-dose vitamin D increased antimicrobial peptide (LL-37) and reduced hs-CRP/ESR — direct immune-modulating evidence.

PubMed ID: 29315160

Large RCT in infants: higher vitamin D dose reduced influenza A incidence and viral load, directly supporting immune protection.

PubMed ID: 29621811

Single high‑dose IM vitamin D in urosepsis produced faster lab improvements and shorter stays, suggesting an immune/host‑response benefit.

PubMed ID: 31099085

RCT: vitamin D supplementation in Marines increased mucosal SIgA and cathelicidin, direct immune biomarker improvement.

PubMed ID: 31241441

Neonatal RCT: adjunct vitamin D lowered sepsis scores and hs-CRP, showing strong immune/anti-infective benefit.

PubMed ID: 34628889

Adjunct vitamin D3 in Graves disease improved autoantibodies and thyroid labs, suggesting immune‑modulating effects.

PubMed ID: 34511168

Active vitamin D (alfacalcidol) RCT in HSP showed higher T‑cell/NK markers and lower inflammatory cytokines and reduced clinical recurrence—direct immune benefit.

PubMed ID: 36029489

In ESRD patients, vitamin D3 reduced inflammatory markers and altered antioxidant signaling—indirectly supporting immune-related anti-inflammatory effects.

PubMed ID: 35281034

Human transcriptome study shows vitamin D (D2/D3) modulates immune and interferon-related pathways, supporting immunomodulatory effects.

PubMed ID: 38589121

Adjunct vitamin D in TB reduced inflammatory markers and improved lymphocyte counts, indicating immune modulation.

PubMed ID: 39560193

Pediatric asthma trial: vitamin D + steroid increased Ig levels and CD4+/CD8+ counts and altered cytokines.

PubMed ID: 31454777

High‑dose cholecalciferol in relapsing MS raised 25(OH)D and reduced MRI lesions/disability among completers, suggesting immune modulation.

PubMed ID: 40063041

High‑dose cholecalciferol RCT in early MS showed reduced MRI disease activity (immunomodulatory effect) indicating immune benefit.

PubMed ID: 38299416

Vitamin D+curcumin reduced SLE activity and cytokines, supporting immune-modulating effect (combination therapy).

PubMed ID: 23999998

Randomized high-dose D increased circulating regulatory T cells — direct immunomodulatory evidence.

PubMed ID: 35527651

Real‑world pediatric study with a multicomponent supplement including vitamin D showed fewer/shorter respiratory infections (immune outcome), though attribution to vitamin D alone is uncertain.

PubMed ID: 29288250

High‑dose vitamin D in ventilated adults reduced an oxidative‑stress marker linked to immune cell function, supporting immune modulation.

PubMed ID: 35733163

Vitamin D plus aerobic training downregulated pro‑inflammatory genes and boosted antioxidant defenses, implying improved immune/inflammatory profile.

PubMed ID: 12588386

Topical vitamin D analog (calcipotriol) improved psoriasis, an immune-mediated skin disease.

PubMed ID: 35082139

VITAL RCT: 2000 IU/day reduced incident autoimmune disease ≈22% — strong direct immune benefit.

PubMed ID: 35899748

Same large VITAL finding (confirmed autoimmune reduction) supporting immune protection.

PubMed ID: 22184801

Multi‑micronutrient including vitamin D reduced common cold symptom scores, especially in deficient subgroups (supports immune effect though combination therapy).

PubMed ID: 31464392

Micronutrient pack including vitamin D raised 25(OH)D and antioxidant enzymes—supports immune resilience via reduced oxidative stress.

PubMed ID: 32519507

Hemodialysis RCT: vitamin D increased antioxidant enzymes and lowered MDA, which may enhance immune function.

PubMed ID: 33508990

RCT in endometriosis: hs‑CRP decreased with vitamin D, indicating reduced inflammatory burden relevant to immunity.

PubMed ID: 35403296

RCT in T2DM showed reduced inflammatory chemokines (MCP‑1, IL‑8) after vitamin D—direct immune/inflammatory effect.

PubMed ID: 25861808

RCT in athletes: high-dose vitamin D raised 25(OH)D and antimicrobial peptides (cathelicidin, SIgA), consistent immune‑support mechanism.

PubMed ID: 40421021

RCT showed vitamin D (esp. high dose + NAC) reduced immune cell senescence markers—supports immune function.

PubMed ID: 26998820

Higher 25(OH)D associated with lower EBV antibody titers in MS, implying immune modulation.

PubMed ID: 27401319

Adjunct vitamin D with SLIT produced immunologic changes (Treg increases) and clinical allergy improvement.

PubMed ID: 33615992

Direct colon-targeted vitamin D changed gut taxa (e.g., B. longum) that influence immune function.

PubMed ID: 25703452

Observational data in ART-naïve HIV patients show common vitamin D deficiency co-occurring with other micronutrient deficits relevant to immune competence.

PubMed ID: 28169875

Strong observational link: low baseline vitamin D associated with much higher incident TB risk, implying immune relevance.

PubMed ID: 24461526

Community RCT of vitamin A+D increased tuberculin skin test responsiveness after BCG revaccination — evidence of enhanced vaccine-related cellular immunity (combination therapy).

PubMed ID: 24926949

Higher/seasonal vitamin D dosing in pediatric IBD linked to fewer elevated inflammatory markers, implying immune benefits.

PubMed ID: 9217273

High‑dose calcitriol raised total and CD8+ T cell counts modestly — direct immunologic effect in humans.

PubMed ID: 9248764

Calcitriol markedly increased pathogen-specific IgE/IgG and altered eosinophil markers — strong immune‑modulating clinical effect.

PubMed ID: 9536226

Topical vitamin D analogue caused significant IL-10 increase and IL-8 decrease, showing local immune modulation.

PubMed ID: 9602870

Combination topical vitamin D+steroid produced superior psoriasis control (immune-mediated benefit).

PubMed ID: 9738781

Adding weekday vitamin D analogue increased remission maintenance in psoriasis (immune-mediated disease).

PubMed ID: 10490297

Topical vitamin D analogue plus UVB accelerated psoriasis improvement (immune-mediated effect).

PubMed ID: 16600924

Vit D raised IL-10 and stabilized TNF-α in HF patients, showing immune-modulatory effects.

PubMed ID: 17463418

Randomized trial: single large vitamin D dose improved blood antimycobacterial activity (BCG‑lux assay).

PubMed ID: 18231120

Infant vitamin D drops raised infant and cord 25(OH)D—plausible support for infant immune development.

PubMed ID: 19817753

Small RCT: vitamin D3 prevented steroid-associated blunting of allergen immunotherapy and preserved Treg induction (immune modulation).

PubMed ID: 19488999

Active vitamin D analogue preserved beta‑cell function in autoimmune diabetes — immunomodulatory benefit in autoimmunity.

PubMed ID: 20219962

Large RCT in children showed vitamin D reduced lab-confirmed influenza A and asthma attacks, direct evidence of immune protection.

PubMed ID: 20491740

Vitamin D supplementation in Crohn's raised 25(OH)D and showed a substantial (borderline-significant) reduction in relapse risk, suggesting immune/inflammatory benefit.

PubMed ID: 20723187

Single high-dose vitamin D at pneumonia treatment reduced repeat pneumonia episodes (implies immune/host defense benefit) though did not speed initial recovery.

PubMed ID: 20438786

Preoperative calcitriol markedly increased intratumoral CD4+/CD8+ infiltration and prolonged time to recurrence — strong immune-modulating signal.

PubMed ID: 21224870

2000 IU/day RCT raised 25(OH)D and produced a marginal increase in tetanus antibody boost—direct evidence of enhanced adaptive immune response.

PubMed ID: 22069289

High-dose monthly D3 increased peripheral regulatory T cells (immunomodulatory effect) in healthy adults.

PubMed ID: 21542721

High-dose D3 produced measurable immunologic changes (↑TGF-β, IL-10, ↓cell proliferation) in MS patients despite no clinical effect.

PubMed ID: 22051697

Gene–vitamin D interaction influenced asthma exacerbations, indicating immunomodulatory relevance of vitamin D status.

PubMed ID: 23204220

RCT in SLE showed improved immunologic markers and trend to lower disease activity—direct immune modulation evidence.

PubMed ID: 22908115

Large RCT in deficient children halved winter ARI rates — clear immune/anti-infective benefit.

PubMed ID: 22362918

Vitamin D added to interferon reduced MRI enhancing lesions in MS, indicating immune modulation in an autoimmune disease.

PubMed ID: 23250818

High‑dose D3 in optic neuritis reduced conversion to MS and new MRI lesions—implies immune effects.

PubMed ID: 22949664

Adjunctive vitamin D in TB reduced proinflammatory responses and sped microbiologic clearance—direct immunomodulatory benefit.

PubMed ID: 22751874

Adjunctive vitamin D increased regulatory T cells and slowed C-peptide loss in new-onset T1DM (immune-preserving effect).

PubMed ID: 22925537

High‑dose vitamin D lowered IL‑6 (an immune/inflammatory cytokine) after 1 year.

PubMed ID: 23611825

Quarterly cholecalciferol altered T-cell phenotype (Th17:Treg) in HIV youth, suggesting immunomodulatory effects.

PubMed ID: 38726565

Maternal supplementation that lowered infant rickets implies improved maternal→fetal calcium/vitamin D transfer and infant mineral metabolism.

PubMed ID: 18259100

IV active vitamin D markedly lowered iPTH and modestly raised serum calcium in dialysis patients — clear calcium‑homeostasis effect.

PubMed ID: 18569914

Monthly high‑dose cholecalciferol raised 25(OH)D and reduced iPTH in CKD predialysis patients — relevant to calcium/PTH control.

PubMed ID: 18445674

Long‑term weekly vitamin D3 dosing safely raised 25(OH)D in children without hypercalcemia — supports improving vitamin D status for calcium physiology.

PubMed ID: 18541590

Dose–response data enable achieving target 25(OH)D levels that support normal calcium absorption and PTH suppression.

PubMed ID: 20516268

800 IU/day raised 25(OH)D substantially for many participants—raises potential for improved calcium handling even though calcium absorption was not directly measured.

PubMed ID: 19185400

Vitamin D3 increased 25(OH)D and lowered iPTH across CKD strata—favorable effects on mineral metabolism relevant to calcium absorption/utilization.

PubMed ID: 19244376

Large increase in 25(OH)D with decreased PTH and improved BMD indicates improved calcium homeostasis/metabolism after high‑dose supplementation.

PubMed ID: 19117033

Oral calcium plus vitamin D after thyroidectomy markedly reduced symptomatic and laboratory hypocalcemia and accelerated calcium recovery.

PubMed ID: 18847321

~800 IU/day prevented winter PTH elevation and stabilized bone turnover in healthy men, consistent with maintaining calcium metabolism.

PubMed ID: 20193095

Vitamin D + calcium raised 25(OH)D, lowered PTH and increased femoral bone measures — indicates improved calcium handling/homeostasis.

PubMed ID: 20646099

High intermittent dosing corrected deficiency and normalized PTH better than low daily dosing — supports effective calcium/vit D physiology.

PubMed ID: 20056003

Very high weekly vitamin D3 markedly raised 25(OH)D and lowered PTH — clear physiological effect closely linked to calcium homeostasis.

PubMed ID: 20308769

Periodic high-dose D3 in deficient schoolgirls increased 25(OH)D and produced small calcium/PTH changes — supports improved calcium economy.

PubMed ID: 21837695

Perioperative Ca+D reduced hypocalcemia incidence and showed calcitriol acts faster in symptomatic correction — direct calcium homeostasis relevance.

PubMed ID: 36591342

Clear biochemical response: vitamin D increased 25(OH)D and modestly decreased PTH, consistent with improved calcium homeostasis.

PubMed ID: 2021135

Ergocalciferol greatly increased 25‑OHD concentrations—supports vitamin D status required for effective calcium absorption.

PubMed ID: 1578308

Dose‑dependent increases in 25‑OHD in infants (prevents rickets), consistent with improved vitamin D availability for calcium metabolism.

PubMed ID: 7498100

Single large dose increased 25(OH)D and lowered PTH in elderly — consistent with improved calcium homeostasis and absorption.

PubMed ID: 9771862

D3 increases 25(OH)D more than D2 — greater substrate for active vitamin D supports calcium handling.

PubMed ID: 9886454

Active vitamin D increased 1,25(OH)2D and improved BMD and fracture outcomes, implying improved calcium handling/absorption.

PubMed ID: 10769438

Alfacalcidol reduced spinal bone loss over 2 years, consistent with improved calcium handling in treated patients.

PubMed ID: 11731184

Active vitamin D analogue decreased PTH and bone turnover and increased spine BMD—evidence of improved calcium economy.

PubMed ID: 15575909

Alfacalcidol lowered PTH and improved spine BMD in transplant recipients, consistent with enhanced calcium handling.

PubMed ID: 17031013

Clear dose-dependent rises in 25-OHD and tendency to lower PTH in responders — supports improved calcium homeostasis.

PubMed ID: 19018785

Supplementation (D2/D3) in extremely obese patients raised 25OHD and cholecalciferol produced stronger PTH suppression—improved calcium regulation.

PubMed ID: 19013526

25OHD dosing in absorptive hypercalciuria increased 1,25(OH)2D more than controls, indicating enhanced substrate→active conversion relevant to calcium handling.

PubMed ID: 19064513

Dose‑response winter trial supplies intake estimates to achieve target 25(OH)D concentrations important for calcium homeostasis.

PubMed ID: 19321573

Supplementation raised 25(OH)D and lowered PTH substantially in deficient overweight adults — consistent with improved calcium homeostasis.

PubMed ID: 21177785

D3 outperformed D2 in raising serum and tissue vitamin D (higher steady-state increments) — pharmacokinetic support for better long-term calcium-related effects with D3.

PubMed ID: 20683712

Oral vitamin D reliably increased 25(OH)D and decreased PTH vs sunlight advice — strong biomarker evidence for improved calcium metabolism.

PubMed ID: 20155247

Increase in 25(OH)D associated with modest PTH reduction — consistent with improved calcium-regulating physiology.

PubMed ID: 21479913

High‑dose D with alendronate corrected deficiency and led to greater bone marker reductions and BMD gains—consistent with improved calcium handling.

PubMed ID: 21706518

Dose‑dependent increases in maternal/neonatal 25(OH)D and increases in 1,25(OH)2D at higher doses indicate stronger substrate for calcium metabolism during pregnancy.

PubMed ID: 21270380

Provides intake estimates to maintain 25(OH)D thresholds important for calcium homeostasis and bone health in adolescents.

PubMed ID: 22266572

Ergocalciferol in CKD children delayed hyperparathyroidism and normalized 25(OH)D — direct effect on calcium/PTH axis.

PubMed ID: 23144810

Inverse association between 25(OH)D and PTH/bone turnover in a large population—supports role in calcium/PTH regulation.

PubMed ID: 22854402

High‑dose cholecalciferol in CKD raised 25(OH)D and produced an early PTH fall—biochemical evidence of improved calciotropic control.

PubMed ID: 23129180

Eldecalcitol (active vitamin D) reduces vertebral fractures — mechanistically tied to calcium/homeostasis and absorption.

PubMed ID: 24001747

D3 raised 25(OH)D substantially more than D2—important for achieving levels that support calcium absorption and mineral homeostasis.

PubMed ID: 23335089

Vitamin D analogue produced marked PTH suppression, consistent with increased effective calcium/vitamin D activity.

PubMed ID: 22882353

RCT: high‑dose oral cholecalciferol raised 25(OH)D faster than IM injection—evidence on effective routes/absorption kinetics.

PubMed ID: 20427425

High‑dose vitamin D normalized 25OHD and PTH in severely deficient adolescents — improved calcium metabolism and bone healing.

PubMed ID: 23427007

Randomized PK study: meal fat content affected 12‑hr plasma cholecalciferol exposure—relevant to optimizing oral absorption.

PubMed ID: 23559332

Infant RCT: 400 IU/day prevented low 25(OH)D and rickets risk — supports adequate calcium/vitamin D status for mineral absorption in infants.

PubMed ID: 23482056

Antenatal weekly high‑dose vitamin D raised maternal and cord 25(OH)D, caused small within-range increases in serum calcium and suppressed PTH — direct evidence of calcium homeostasis effects.

PubMed ID: 25406966

High‑dose vitamin D3 in obese T2D substantially increased 25(OH)D and lowered PTH — biochemical evidence of improved calcium handling.

PubMed ID: 25441954

Single-dose study showed ~32% greater vitamin D3 absorption when taken with a fatty meal—important mechanistic support for improving vitamin D bioavailability and calcium handling.

PubMed ID: 24825262

Rickets trial: substantial biochemical effects (25OHD rise, PTH/ALP fall) accompanying radiologic healing—consistent with improved calcium/phosphate metabolism.

PubMed ID: 25572630

CKD RCT: modified‑release calcifediol rapidly raised 25OHD and produced dose‑dependent reductions in iPTH—strong evidence of improved mineral homeostasis/calcium handling.

PubMed ID: 24535626

Short‑term high‑dose vitamin D3 increased total/free 1,25(OH)2D — the active hormone that promotes intestinal calcium absorption (direct biochemical evidence).

PubMed ID: 25417309

Use of active 1,25(OH)2D3 in fusion patients improved bone healing rates, consistent with enhanced mineral metabolism/calcium handling.

PubMed ID: 25248651

Calcidiol restored 25(OH)D and decreased PTH in hypogonadal men—direct evidence of improved calcium homeostasis.

PubMed ID: 26030788

Premature infant RCT: higher vitamin D dose increased free 25(OH)D and free vitamin D at birth correlated with bone mineral content — supports improved bioavailable vitamin D relevant to calcium handling.

PubMed ID: 25801893

Higher-dose regimen achieved much higher rates of 25(OH)D sufficiency in SLE patients—evidence of effective vitamin D repletion (enabling calcium metabolism).

PubMed ID: 25929192

Cholecalciferol combined with alendronate increased 25(OH)D and BMD—consistent with improved calcium availability for bone.

PubMed ID: 26514332

Buccal spray markedly increased serum 25(OH)D versus soft-gel, especially in malabsorption patients—evidence about improved vitamin D absorption/bioavailability.

PubMed ID: 26151421

High single intramuscular/oral doses rapidly corrected deficiency and maintained higher 25(OH)D for months—strong evidence vitamin D repletion for calcium metabolism.

PubMed ID: 26308708

Use of a vitamin D analogue (alfacalcidol) with antiresorptive therapy prevented bone loss—consistent with enhanced calcium‑handling physiology.

PubMed ID: 28065190

Cholecalciferol raised total 25(OH)D and reduced PTH more than ergocalciferol in CKD patients—indicative of better mineral metabolism/calcium handling.

PubMed ID: 26965764

Long‑term supplementation in deficient adults raised 25(OH)D and lowered PTH demonstrating improved calcium homeostasis/indirect absorption effect.

PubMed ID: 27184759

Maternal/infant supplementation increased infant 25(OH)D and reduced high alkaline phosphatase consistent with improved mineral metabolism/calcium handling.

PubMed ID: 27189286

Repletion in postmenopausal women (≈2000 IU/day) achieved ≥50 nmol/L quickly, supporting restoration of calcium‑related physiology.

PubMed ID: 26959482

Child supplementation increased 25(OH)D and modeling suggested higher intakes are needed to maintain sufficiency (implicates calcium/vitamin D homeostasis).

PubMed ID: 27683282

Single large oral doses corrected deficiency in young children and showed lab evidence of calcium changes—supports effects on calcium handling.

PubMed ID: 27837387

Loading regimen effectively restored 25(OH)D and suppressed PTH after bariatric surgery—strong evidence of improved calcium/PTH physiology.

PubMed ID: 31104833

Switch from conventional therapy (including active vitamin D) to burosumab altered phosphate/bone outcomes—illustrates role of active vitamin D in mineral handling.

PubMed ID: 30624670

Monthly dosing raised 25(OH)D and lowered PTH dose-dependently—mechanistically linked to calcium homeostasis.

PubMed ID: 30898175

Micellised vitamin D led to larger 25(OH)D increases and a significant PTH decline, indicating improved calcium homeostasis/absorption.

PubMed ID: 31731651

Calcifediol produced faster 25(OH)D increases and more PTH suppression than cholecalciferol—direct improvement in calcium homeostasis.

PubMed ID: 31820121

Adding cholecalciferol to risedronate raised 25(OH)D and lowered PTH, supporting calcium handling though BMD unchanged.

PubMed ID: 32052217

Dose‑response increases in 25(OH)D and reductions in PTH indicate improved calcium handling/absorption.

PubMed ID: 32968158

Cholecalciferol in hemodialysis patients raised 25(OH)D and 1,25(OH)2D (active form), indicating enhanced potential for calcium metabolism.

PubMed ID: 31518424

25‑OH‑D3 rapidly raises serum 25(OH)D (more potent repletion), supporting calcium metabolism and absorption indirectly.

PubMed ID: 32415923

Calcitriol (active vitamin D) combined with sevelamer improved PTH and mineral markers in CKD (direct mineral metabolism effect).

PubMed ID: 36286834

Selective VDRA normalized PTH and increased Klotho in CKD patients—clear effects on mineral metabolism relevant to calcium handling/absorption homeostasis.

PubMed ID: 33565715

Daily 4000 IU cholecalciferol corrected deficiency in kidney transplant patients, which would be expected to improve calcium metabolism though direct calcium absorption measures not reported.

PubMed ID: 35014613

Higher maternal dosing substantially raised maternal and infant 25(OH)D, the key hormone for calcium absorption (biochemical support).

PubMed ID: 34849546

Supplementation reduced PTH substantially in deficient individuals, reflecting improved vitamin D–mediated calcium handling and absorption effects on mineral metabolism.

PubMed ID: 35692883

Calcitriol (active vitamin D) increases calcium handling; trial showed improved bone outcomes when combined with bisphosphonate.

PubMed ID: 35034345

PK evidence of robust systemic 25(OH)D exposure suggests effective substrate for calcium absorption and bone mineral homeostasis.

PubMed ID: 35988059

Eldecalcitol is an active vitamin D analogue used to affect calcium/bone metabolism; formulation bioequivalence supports expected calcium‑related effects.

PubMed ID: 37375660

Daily vitamin D in toddlers reliably raised serum 25(OH)D, supporting the vitamin D–calcium axis essential for absorption and mineralization.

PubMed ID: 36913250

High‑dose repletion in deficient obese youths normalized 25(OH)D, a prerequisite for optimal calcium absorption even though short‑term metabolic change was absent.

PubMed ID: 39599585

Calcifediol rapidly and dose‑dependently restored 25(OH)D to target levels — directly facilitating calcium metabolism/absorption.

PubMed ID: 39264438

Vitamin D raised 25(OH)D and blunted the expected PTH rise in thyrotoxic patients — indicating improved calcium homeostasis.

PubMed ID: 18492750

Cholecalciferol raised 25(OH)D more than ergocalciferol and lowered PTH — demonstrates stronger effect on vitamin D status and downstream calcium regulation.

PubMed ID: 39174041

IM 300,000 IU achieved 100% sufficiency at 12 weeks — effective repletion that supports calcium handling.

PubMed ID: 38542750

Supplementation lowered PTH and changed vitamin D metabolites—supports calcium homeostasis.

PubMed ID: 40005002

Calcifediol quickly raised 25(OH)D and lowered PTH, consistent with improved calcium homeostasis.

PubMed ID: 40205202

Calcifediol produced higher achieved 25(OH)D than cholecalciferol, supporting stronger biological availability for calcium handling.

PubMed ID: 39815761

Pharmacogenomic RCT showed genetic loci modulate changes in 1,25(OH)2D3 and PTH after supplementation — mechanistic evidence for variable calcium/vitamin D biology.

PubMed ID: 39929761

Infant study defined 25‑OH‑D threshold where PTH begins to rise — direct physiologic link between vitamin D and calcium/PTH homeostasis.

PubMed ID: 36334119

Adding a probiotic to calcitriol + calcium raised vitamin D3 and lowered PTH in postmenopausal women—favorable shifts in calcium-regulating hormones.

PubMed ID: 36799782

Perioperative calcium + vitamin D (started before surgery) reduced early postoperative hypocalcemia and increased early postop calcium—practical calcium homeostasis benefit.

PubMed ID: 37111231

Fortified milk with calcium + vitamin D raised 25(OH)D and IGF‑1 while lowering PTH and increased bone mineral accrual—consistent with improved calcium handling for bone formation.

PubMed ID: 37909613

In hypoparathyroid patients on active vitamin D, dietary calcium advice corrected hypocalcemia in most patients—demonstrates interaction between vitamin D therapy and calcium homeostasis.

PubMed ID: 37814913

Paricalcitol (vitamin D analog) + cinacalcet improved phosphorus/calcium control in dialysis patients—mineral metabolism impact.

PubMed ID: 38325238

Supplementation with vitamin D + milk/calcium improved bone accrual—implies better calcium utilization/absorption.

PubMed ID: 39266931

Education intervention improved serum calcium regulation and stabilized PTH in dialysis patients (calcium homeostasis outcome).

PubMed ID: 38477739

Weekly 10,000 IU greatly raised 25(OH)D and lowered PTH in children, consistent with improved calcium metabolism.

PubMed ID: 23761968

Monthly cholecalciferol normalized 25(OH)D and reduced PTH in osteoporotic patients, indicating improved calcium homeostasis.

PubMed ID: 29044707

High‑dose cholecalciferol lowered PTH and bone turnover in CKD patients—consistent with improved calcium handling.

PubMed ID: 32131365

Maternal vitamin D increased offspring bone formation response to loading — consistent with improved maternal/fetal mineral economy and calcium utilization.

PubMed ID: 36216304

Calcitriol reduced PTH and bone turnover markers in CKD patients — direct evidence of manipulating active vitamin D pathway and mineral metabolism.

PubMed ID: 8052367

Calcitriol (active vitamin D) caused large suppression of PTH and expected alterations in calcium/phosphate, directly showing improved calcium‑regulating effects in CKD/dialysis patients.

PubMed ID: 22300739

Ergocalciferol raised 25(OH)D and 1,25(OH)2D and increased urinary phosphate excretion and FGF23, demonstrating strong effects on mineral metabolism and calcium/phosphate handling.

PubMed ID: 21832027

Fortified milk raised 25(OH)D and reduced deficiency in toddlers; PTH unchanged but raising 25(OH)D supports calcium metabolism overall.

PubMed ID: 25012612

Injected vitamin D corrected deficiency and lowered PTH—strong biochemical evidence of improved calcium homeostasis/absorption.

PubMed ID: 22086300

1600 IU/day raised 25(OH)D substantially (biomarker required for calcium absorption), though bone markers unchanged.

PubMed ID: 25694350

Dose‑dependent rise in 25(OH)D with inverse PTH changes supports improved calcium homeostasis/absorption.

PubMed ID: 24397515

Animal study with active 1,25(OH)2D3 improved calcium retention and tibia mineralization — mechanistic support for calcium metabolism (animal model).

PubMed ID: 29151102

Postmenopausal study: vitamin D increases associated with lower PTH and bone‑turnover markers consistent with improved calcium handling/homeostasis.

PubMed ID: 26481332

Fish/fish‑oil supplementation raised 25OHD and affected parathyroid hormone/ALP in deficient children—supports improved calcium/vitamin D physiology.

PubMed ID: 29500675

Multivitamin after gastric bypass increased vitamin D and lowered PTH—biochemical pattern consistent with improved calcium homeostasis/absorption.

PubMed ID: 12791627

Fortification with vitamin D (1000 IU/day) substantially raised 25(OH)D and lowered PTH—indicates improved calcium homeostasis/absorption.

PubMed ID: 24267005

Supplementation in children produced a dose‑response increase in 25(OH)D and affected bone biomarkers (iPTH/osteocalcin), relevant to calcium handling.

PubMed ID: 29733445

Vitamin D3 modestly lowered PTH in postmenopausal women with insufficiency, consistent with improved calcium regulation.

PubMed ID: 31338563

Supplement raised 25(OH)D and suppressed PTH in older adults—consistent with improved calcium metabolism.

PubMed ID: 1823383

Administration of calcitriol produced expected increases in serum and urinary calcium and lowered PTH—clear physiological evidence of enhanced calcium handling.

PubMed ID: 1729617

Calcitriol improved fracture outcomes and was associated with increases in calcium absorption in study context—strong relevance to calcium metabolism.

PubMed ID: 8172088

Single high oral dose increased 25(OH)D and modestly lowered PTH without raising calcium—favorable calcium‑regulation signal.

PubMed ID: 8074071

High intermittent doses produced large increases in 25(OH)D and transient hypercalcemia at highest dose—demonstrates potent calcium‑metabolism impact.

PubMed ID: 7606425

Vitamin D3 with calcium raised 25-OH-D and reduced PTH in deficient elderly—biochemical environment favoring improved calcium handling.

PubMed ID: 7852497

Short-term 25OHD pretreatment in winter directly increased intestinal calcium absorption—strong mechanistic evidence.

PubMed ID: 8599316

Lactation and especially after weaning associated with higher calcitriol and increased intestinal calcium absorption — strong physiologic evidence.

PubMed ID: 8805994

Dose‑response calcitriol study in healthy men produced large, dose‑dependent increases in urinary calcium and PTH suppression — direct evidence of potent vitamin D action on calcium handling.

PubMed ID: 8883116

Alfacalcidol (active analogue) increased fractional calcium absorption and lowered PTH; vitamin D2 increased 25(OH)D but did not increase absorption.

PubMed ID: 9797910

Ca + vitamin D increased spine BMD and raised urinary calcium consistent with increased intestinal calcium absorption in postmenopausal women.

PubMed ID: 9568825

Intermittent 1α‑hydroxyvitamin D2 strongly suppressed PTH in dialysis patients, consistent with improved calcium balance mediated by vitamin D analogues.

PubMed ID: 9737353

Calcitriol markedly increased renal calcium excretion and lowered PTH, demonstrating active vitamin D's strong effects on calcium handling.

PubMed ID: 9504953

Fortified milk raised 25OHD in elderly, which supports improved calcium regulation and absorption indirectly.

PubMed ID: 9797906

Dose–response quantification of how oral D3 raises 25(OH)D (and 1,25 in some dosing) underpins vitamin D's role in intestinal calcium absorption.

PubMed ID: 9808143

Short IV paricalcitol lowered PTH in dialysis patients with calcium remaining in normal range—supports vitamin D analogue effects on calcium homeostasis.

PubMed ID: 9734615

Intraperitoneal calcitriol produced large PTH suppression and raised serum calcium—direct evidence that active vitamin D alters calcium homeostasis.

PubMed ID: 10982163

Calcitriol + calcium increased urinary calcium markedly — indicates increased intestinal absorption/renal calcium load with active vitamin D.

PubMed ID: 10663358

Calcitriol added to HRT improved/prevented declines in fractional calcium absorption, especially in malabsorbers.

PubMed ID: 10701059

High‑dose seasonal D3 prevented winter PTH rises, indicating preserved calcium homeostasis.

PubMed ID: 11549632

Calcitriol increased fractional calcium absorption by ~34% in men with osteoporosis.

PubMed ID: 11297596

Vitamin D3 + calcium raised 25OHD (+72%) and lowered PTH (−17%), reflecting improved calcium-regulatory status.

PubMed ID: 11576883

Paricalcitol raised serum calcium and lowered PTH in dialysis patients—demonstrates effect on calcium regulation.

PubMed ID: 11157326

Daily vitamin D3 (25 or 100 µg) raised 25(OH)D dose-dependently without hypercalcemia, supporting improved vitamin D status and calcium homeostasis.

PubMed ID: 11689388

Paricalcitol in dialysis lowered PTH faster without increasing calcium—relevant to calcium-phosphate-PTH control in CKD.

PubMed ID: 11277275

Calcitriol post-transplant partially reduced early bone loss, implying improved mineral homeostasis in a high-risk setting.

PubMed ID: 11689389

iPTH-guided paricalcitol dosing achieved faster PTH reductions without hypercalcemia—improves targeted calcium-PTH management.

PubMed ID: 11420782

800 IU/day increased 25-OHD by ~25.4 nmol/L and modestly lowered PTH in deficient subjects—improves calcium-regulatory markers.

PubMed ID: 11716192

Seasonal high-dose D3 maintained 25(OH)D and prevented winter PTH rise in adolescents—direct prevention of secondary hyperparathyroidism and preserved calcium balance.

PubMed ID: 11250664

Milk powder supplementation reliably increased dietary vitamin D and calcium intake in older nursing-home residents (improves substrate for calcium absorption).

PubMed ID: 11991447

Daily Ca+vitD normalized 25(OH)D and PTH in institutionalized elderly, preventing hip bone loss—clear effect on calcium homeostasis.

PubMed ID: 12490862

Perioperative oral calcium ± vitamin D reduced symptomatic hypocalcemia after thyroidectomy, showing effective calcium support.

PubMed ID: 12036821

Three-year supplementation arms sustained increased 25(OH)D across groups, affecting calcium-regulatory status though marker changes were transient.

PubMed ID: 12027147

In vitamin D–deficient postmenopausal women, adding vitamin D to calcium markedly raised serum 25(OH)D and lowered PTH — direct evidence of improved calcium handling.

PubMed ID: 11961400

Dose‑response IV calcitriol in dialysis clearly suppressed PTH and raised serum calcium in a dose‑dependent manner — direct effect on calcium metabolism.

PubMed ID: 12184546

Active vitamin D after gastrectomy changed serum calcium and PTH favorably, indicating improved calcium handling/absorption.

PubMed ID: 12671829

Intermittent calcitriol blurred PTH and mineral outcomes and raised serum calcium—demonstrates substantial calcium-regulatory effects.

PubMed ID: 12631365

Paricalcitol (vitamin D analog) produced rapid, consistent PTH suppression and better mineral control in dialysis—direct calcium/PTH effect.

PubMed ID: 14602746

Calcium + vitamin D normalized 25‑OHD and reduced PTH and bone resorption markers, consistent with improved calcium handling.

PubMed ID: 14569109

Alfacalcidol (active vitamin D) lowered PTH and prevented bone loss, reflecting improved calcium handling/metabolism after renal transplant.

PubMed ID: 12499343

Quantitative cholecalciferol dosing directly increased 25(OH)D — the substrate required to support active vitamin D synthesis and calcium absorption.

PubMed ID: 15231008

Winter vitamin D3 + calcium normalized calciotropic hormones and turnover markers, indicating improved calcium homeostasis.

PubMed ID: 15221494

Alfacalcidol lowered PTH and decreased bone resorption, consistent with improved calcium metabolism and absorption effects.

PubMed ID: 15663548

Oxacalcitriol produced dose-dependent PTH suppression and raised serum calcium/phosphate — demonstrates influence on calcium homeostasis.

PubMed ID: 15112179

Doxercalciferol substantially lowered PTH and bone turnover markers without hypercalcemia—indirect evidence of altered calcium metabolism.

PubMed ID: 15031343

Alfacalcidol markedly suppressed PTH and improved BMD in CKD, reflecting improved calcium handling/availability.

PubMed ID: 15260882

Higher vitamin D dose raised 25(OH)D and suppressed PTH, consistent with improved calcium homeostasis.

PubMed ID: 15668602

Vitamin D‑fortified milk increased serum 25OHD and reduced bone resorption markers, supporting calcium/bone metabolism.

PubMed ID: 16491287

Fortified milk raised 25(OH)D and lowered PTH in older men, consistent with improved calcium balance and reduced bone resorption.

PubMed ID: 16382319

Calcium + vitamin D reduced steroid‑associated bone loss in children — supports improved calcium economy under steroid stress.

PubMed ID: 15807187

Alfacalcidol (active vitamin D) substantially suppressed PTH and improved bone turnover markers in dialysis patients — indicates potent mineral‑metabolism effects.

PubMed ID: 16043680

Supplementation raised 25‑OHD substantially in African‑American women — improved vitamin D status that underpins calcium absorption, though bone outcomes were unchanged.

PubMed ID: 15883444

Fortified milk markedly lowered PTH and bone turnover in girls, consistent with improved calcium economy.

PubMed ID: 16105530

Calcitriol after thyroidectomy prevented severe hypocalcemia — strong evidence of improved calcium handling/homeostasis.

PubMed ID: 15883634

VDR Fok1 genotype associated with differences in calcium absorption and bone accrual — directly links vitamin D signaling to calcium uptake (genetic evidence).

PubMed ID: 16189633

Calcitriol and vitamin D analogs suppressed PTH and bone turnover in dialysis patients, altering mineral metabolism and calcium homeostasis directly.

PubMed ID: 16076940

Adolescent observational study showed 25-OHD inversely correlated with PTH and, in subjects with 25-OHD <25 ng/mL, 25-OHD related negatively to fractional calcium absorption — direct biochemical relevance to calcium absorption in deficient subgroup.

PubMed ID: 15899959

Supplemental cholecalciferol in a large cohort normalized vitamin D status in most women — improving vitamin D status is expected to enhance calcium handling even if absorption was not directly measured.

PubMed ID: 16371185

Oral vitamin D plus calcium after thyroidectomy raised early serum calcium and reduced hypocalcemia incidence — direct evidence of improved calcium handling clinically.

PubMed ID: 16283320

Alfacalcidol produced superior BMD gains compared with standard vitamin D+calcium; as an active analog, it's expected to improve calcium utilization and bone mineralization.

PubMed ID: 15840055

Alfacalcidol decreased iPTH and prevented bone loss post-transplant, indicating improved mineral (calcium) economy.

PubMed ID: 17163358

Calcitriol pre-treatment increased pre-op calcemia and reduced post-op hypocalcemia risk — active vitamin D improved calcium availability.

PubMed ID: 16391587

High-dose vitamin D2 rapidly raised 25OHD and reduced PTH and a bone marker — biochemical repletion consistent with improved calcium economy.

PubMed ID: 16960175

Defined a serum 25‑OH D threshold (~40–50 nmol/L) below which PTH rises—physiologic evidence linking vitamin D status to calcium/PTH homeostasis.

PubMed ID: 16792136

Alfacalcidol effectively lowered PTH in hemodialysis patients—direct evidence of vitamin D analog influence on calcium/PTH regulation.

PubMed ID: 17243866

D+Ca+vitamin K raised 25(OH)D and lowered PTH with modest bone benefit—supports improved calcium metabolism.

PubMed ID: 17874029

Dosing regimens in elderly markedly raised 25(OH)D and reduced PTH—expected to improve calcium handling and retention (strong surrogate evidence).

PubMed ID: 17493196

Alendronate + calcitriol produced large PTH suppression and greater spine BMD—active vitamin D clearly affected mineral metabolism consistent with improved calcium handling.

PubMed ID: 17556694

High-dose vitamin D2 regimens raised serum 25(OH)D significantly in deficient women—improving substrate for calcium absorption though many remained below sufficiency.

PubMed ID: 17269594

Maxacalcitol and calcitriol produced similar calcium, phosphate and PTH results in dialysis patients—relevant to vitamin D analog effects on mineral metabolism.

PubMed ID: 18065583

Dose‑dependent increases in serum 25(OH)D and marked PTH suppression are consistent with improved calcium economy; trial shows biochemical efficacy of supplementation.

PubMed ID: 17437343

Post‑thyroidectomy RCT showing that routine oral calcium + vitamin D markedly reduced symptomatic hypocalcemia and shortened hospital stay — direct evidence of improved calcium homeostasis in that setting.

PubMed ID: 18413426

Infant dosing regimens (D2 or D3, daily/weekly) tripled 25(OH)D and showed biochemical safety and PTH effects — relevant to calcium metabolism.

PubMed ID: 19101755

Loading and monthly regimens raised 25(OH)D and suppressed PTH in deficient subjects — supports improved calcium homeostasis.

PubMed ID: 18515308

Active vitamin D (calcitriol) administration route trial in dialysis patients showed prevention of parathyroid enlargement and changes in bone markers — direct active‑vitamin‑D effects on calcium/PTH dynamics.

PubMed ID: 18593741

High‑dose weekly vitamin D in dialysis restored 25(OH)D in many patients and safely maintained higher levels — improves substrate for calcium homeostasis.

PubMed ID: 18802363

Cholecalciferol corrected 25(OH)D deficiency and lowered PTH in CKD stages 2–4 without sustained hypercalciuria — supports improved calcium regulation.

PubMed ID: 18996761

High‑dose vitamin D corrected deficiency after gastric bypass and attenuated cortical bone loss — implies restoration of vitamin D–dependent calcium handling.

PubMed ID: 21448918

Randomized trial showed alendronate + vitamin D significantly increased fractional calcium absorption and raised 25(OH)D within one month (direct mechanistic evidence).

PubMed ID: 21342321

Active vitamin D sterols (calcitriol/alfacalcidol) produced large PTH reductions in dialysis patients, reflecting strong effects on calcium/PTH homeostasis.

PubMed ID: 22130786

Alfacalcidol (active D) blunted secondary PTH rise and improved spine BMD when added to raloxifene — indicates improved calcium handling/metabolism.

PubMed ID: 22855333

Large trial: higher vitamin D doses produced large increases in serum 25OHD but only ~+6% absolute increase in fractional calcium absorption—direct measurement of calcium absorption.

PubMed ID: 23364004

Randomized controlled study with isotopic measurement showed vitamin D supplementation increased true fractional calcium absorption in vitamin D‑insufficient postmenopausal women.

PubMed ID: 24335055

Dose‑ranging RCT directly measured fractional calcium absorption and demonstrated a linear, dose‑dependent increase with higher vitamin D doses.

PubMed ID: 23595003

Dosing regimens increased serum 25‑OH‑D (and showed hypercalciuria at high dose)—directly impacts calcium homeostasis and absorption risk.

PubMed ID: 23585346

Dose‑dependent 25(OH)D increases and PTH reduction with 1000 IU/day imply improved calcium economy.

PubMed ID: 24712573

Vitamin D repletion produced expected PTH and calcium responses; DBP did not alter this functional calcium response.

PubMed ID: 24748637

Adding vitamin D to calcium in rickets increased 25(OH)D and hastened biochemical recovery consistent with improved calcium handling.

PubMed ID: 24937546

High-dose antenatal vitamin D modestly increased cord calcium and attenuated neonatal calcium nadir—affecting neonatal calcium balance.

PubMed ID: 24423366

High-dose vitamin D in primary hyperparathyroidism lowered PTH and improved spine BMD, indicating improved calcium economy.

PubMed ID: 24401754

Treatment of nutritional rickets (high‑dose vitamin D) led to clinical and biochemical healing consistent with restored calcium homeostasis.

PubMed ID: 24856872

Weekly 25,000 IU cholecalciferol raised 25(OH)D and 1,25(OH)2D and increased the proportion of patients achieving target serum calcium in hemodialysis.

PubMed ID: 25166750

Daily 3000 IU raised circulating 25(OH)D and active 1,25(OH)2D, biochemical precursors that promote intestinal calcium absorption.

PubMed ID: 26312580

Randomized dose study showed free 25(OH)D tracked total 25(OH)D and that neither better-predicted calcium absorption or PTH—directly addresses calcium absorption measurement question.

PubMed ID: 26267985

High-dose ergocalciferol in CKD raised 25(OH)D and produced a modest PTH reduction—supports improved calcium‑regulatory status.

PubMed ID: 26280790

Fortified-food dosing produced large 25(OH)D increases and PTH lowering at high dose—evidence of improved calcium balance/absorption at high intake.

PubMed ID: 26237520

RCT raising 25(OH)D produced a small but statistically significant increase (~1% TFCA) in intestinal calcium absorption.

PubMed ID: 25656524

Single oral 25‑OH vitamin D raised 25(OH)D and transiently suppressed PTH in dialysis patients—demonstrates improved vitamin D status and effects on calcium/PTH axis.

PubMed ID: 25899914

Calculated loading regimen rapidly achieved target 25(OH)D concentrations in deficient elderly—directly improves substrate for intestinal calcium handling and bone mineralization.

PubMed ID: 27325795

VLBW infants given 1000 IU/day had higher serum calcium and lower PTH/ALP vs 400 IU — direct evidence of improved calcium homeostasis at higher vitamin D dosing.

PubMed ID: 27986983

Dose‑dependent increases in 25(OH)D and reductions in PTH are mechanistically linked to improved calcium handling.

PubMed ID: 27676085

ER calcifediol normalized 25(OH)D and reduced iPTH in CKD — supports improved calcium/PTH homeostasis.

PubMed ID: 29273827

Active vitamin D analogues (ELD, ALF) produced very large, direct increases in fractional intestinal calcium absorption vs plain D3.

PubMed ID: 28528472

Perioperative iPTH/24h Ca predictions help determine who needs Ca/vit D supplementation to prevent hypocalcemia — clinically relevant to calcium management.

PubMed ID: 28187226

Calcifediol raised total and free 25(OH)D faster and more than cholecalciferol with correlated PTH changes — strong physiological evidence for improved calcium-regulating effects.

PubMed ID: 28832406

Vitamin D + calcium blunted PTH rise and preserved BMD in ART patients — supports improved calcium economy and bone mineral support.

PubMed ID: 27768857

2000 IU/day RCT raised total and bioavailable 25(OH)D and lowered PTH substantially — consistent with improved calcium handling.

PubMed ID: 28795342

Weekly high-dose cholecalciferol increased active vitamin D and moderated PTH — consistent with effects on calcium/phosphate homeostasis.

PubMed ID: 28332096

Paricalcitol lowered iPTH in pediatric CKD—affects mineral metabolism including calcium regulation (vitamin D receptor agonist effect).

PubMed ID: 28429905

Maintenance vitamin D3 regimens raised 25(OH)D and monitored PTH/calcium safety, supporting improved calcium homeostasis/absorption.

PubMed ID: 29676968

Fortified milk with vitamin D raised 25(OH)D and femoral neck BMD, consistent with improved calcium handling and bone mineralization.

PubMed ID: 29970059

Adding native vitamin D to alendronate increased 25(OH)D and had favorable urinary calcium profile vs calcitriol—supports appropriate calcium handling.

PubMed ID: 29156056

High‑dose cholecalciferol in CKD raised 1,25(OH)2D and attenuated secondary hyperparathyroidism, indicating improved calcium/metabolic handling.

PubMed ID: 29931358

In deficient adults rising free 25(OH)D associated with increases in downstream metabolites and early PTH decline — supports improved vitamin D bioavailability and calcium regulation.

PubMed ID: 31669447

2000 IU/day significantly raised 25(OH)D and lowered iPTH without hypercalcemia — consistent with improved calcium metabolism.

PubMed ID: 31776371

Dose-dependent PTH declines at higher vitamin D doses indicate improved calcium homeostasis.

PubMed ID: 30843501

Dose-ranging RCT: higher vitamin D doses raised 25(OH)D and reduced secondary hyperparathyroidism—direct effect on calcium homeostasis.

PubMed ID: 32466854

Preoperative vitamin D markedly reduced early symptomatic hypocalcemia and IV calcium need after thyroidectomy—strong evidence of benefit for calcium homeostasis.

PubMed ID: 34748169

Routine calcium+vitamin D after total thyroidectomy reduced symptomatic hypocalcemia—evidence vitamin D aided acute calcium homeostasis.

PubMed ID: 34702443

Short calcitriol preop shortened duration of postoperative hypocalcemia—supports effect on calcium handling though not incidence.

PubMed ID: 34470599

Infant supplementation corrected deficiency and normalized iPTH—supports calcium homeostasis and absorption in infants.

PubMed ID: 34371803

Pharmacodynamic RCT showed ↑1,25(OH)2D and ↓PTH after cholecalciferol dosing — direct mechanistic evidence of improved calcium‑regulating physiology.

PubMed ID: 35059187

BMI‑based dosing maintained higher 25OHD and lowered PTH versus fixed dosing — supports improved/calibrated calcium homeostasis.

PubMed ID: 36459369

Preoperative calcitriol raised postoperative serum calcium and reduced symptomatic hypocalcemia—strong evidence of improved calcium handling.

PubMed ID: 35176038

In hemodialysis patients, concomitant IV vitamin D receptor activator improved corrected calcium target achievement—evidence of improved calcium control.

PubMed ID: 36364809

Weight‑based loading + maintenance rapidly and safely raised 25(OH)D in colorectal cancer patients, supporting calcium/vitamin D physiological balance.

PubMed ID: 39020381

Significant reductions in salivary and tissue IFN-γ with vitamin D adjunct.

PubMed ID: 32475360

High‑dose weekly vitamin D lowered CRP significantly (strong anti‑inflammatory signal).

PubMed ID: 34459959

Daily 2000 IU improved histologic hepatic steatosis and lobular inflammation in children with NAFLD.

PubMed ID: 35067753

Fish oil + vitamin D reduced TNF‑α and ALT, indicating reduced inflammation.

PubMed ID: 36279014

Metabolomics trial (fish oil ± vitamin D) found PC species correlated inversely with inflammatory cytokines; vitamin D part of intervention.

PubMed ID: 37667938

Randomized trial in NAFLD showed reductions in hs‑CRP, STAT‑3 and other inflammation/oxidative stress markers with vitamin D.

PubMed ID: 25091714

Vitamin D adjunct in asthma produced superior lung function at 24 weeks—likely reflecting reduced airway inflammation.

PubMed ID: 36079732

Multi-ingredient supplement that included vitamin D produced reductions in IL-6 and CRP in elderly inpatients (inflammation markers decreased; attribution indirect).

PubMed ID: 26653112

High‑dose vitamin D decreased a T‑cell activation marker, consistent with reduced adaptive immune activation/inflammatory signaling.

PubMed ID: 31049877

RCT showed attenuation of IL‑6 rise (clinically relevant inflammatory marker) with vitamin D‑containing supplement.

PubMed ID: 8949429

Topical vitamin D analogue (calcipotriol) reduced keratinocyte proliferation and inflammatory cell markers in psoriasis—direct anti‑inflammatory skin effects.

PubMed ID: 9892908

Large RCT: topical vitamin D analogue combined with corticosteroid reduced psoriasis severity and irritation vs vitD alone—anti‑inflammatory clinical benefit.

PubMed ID: 22515652

Topical vitamin D analogue improved scalp psoriasis when used with steroid for longer duration—clinical reduction in skin inflammation.

PubMed ID: 33067129

Fortified product (HMB+vitD/C) prevented hs‑CRP increase in sarcopenic elders—suggests systemic inflammation attenuation (multi‑ingredient).

PubMed ID: 1390171

Topical vitamin D analogue (calcipotriol) produced large clinical improvement in psoriasis, an inflammatory skin disease.

PubMed ID: 8252786

Occlusion increased topical calcipotriol efficacy for psoriasis without systemic calcium effects—implies stronger local anti‑inflammatory action.

PubMed ID: 7999599

Topical calcipotriol reduced psoriasis severity (an inflammatory skin disease)—supports anti-inflammatory skin effects.

PubMed ID: 11260005

Calcitriol + UVB reduced PASI and UVB exposure, showing reduced inflammatory activity in psoriasis.

PubMed ID: 12037450

Topical vitamin D analog (calcipotriol) reduced psoriasis severity (inflammatory skin disease) without systemic disturbance.

PubMed ID: 14521705

Topical vitamin D analog reduced psoriasis lesion severity (an inflammatory skin condition), reflecting local anti‑inflammatory action.

PubMed ID: 14708413

IV calcitriol significantly decreased iPTH and pro‑inflammatory cytokines (TNF‑α, IL‑1, IL‑6) in dialysis patients.

PubMed ID: 15587751

Calcitriol lowered serum IL‑1 and TNF‑α in postmenopausal women with osteoporosis.

PubMed ID: 17668541

Topical calcitriol (vitamin D3 analog) produced clinical improvement in psoriasis (an inflammatory skin disease), supporting anti-inflammatory effects locally.

PubMed ID: 17373972

Topical calcitriol was as effective as calcipotriol for plaque psoriasis with fewer local adverse events, consistent with reduced local inflammation.

PubMed ID: 21724580

Randomized trial showed a significant reduction in a combined inflammation z‑score after 6 months of 800 IU/day vitamin D.

PubMed ID: 22114787

Vitamin D–fortified yogurt raised 25(OH)D and improved endothelial inflammatory biomarkers (ET-1, E-selectin, MMP-9) in type 2 diabetes.

PubMed ID: 21691817

Reduction in aromatase inhibitor–related musculoskeletal pain suggests anti-inflammatory or analgesic benefit from high-dose vitamin D2.

PubMed ID: 21697250

High-dose cholecalciferol suppressed pathogenic PBMC responses to myelin antigens (an anti-inflammatory/immunomodulatory signal).

PubMed ID: 22019331

Calcitriol reduced proteinuria in IgA nephropathy, consistent with anti‑inflammatory/immunomodulatory renal effects.

PubMed ID: 22442277

Double‑blind RCT in T2D with consistent decreases in multiple inflammatory biomarkers following vitamin D‑fortified drink.

PubMed ID: 22344966

RCT in T2D showed significant reductions in hsCRP, IL‑6, TNF‑α and SAA after vitamin D fortification.

PubMed ID: 22350110

Single large oral D3 dose before zoledronate lowered inflammatory markers vs placebo (direct anti-inflammatory signal in this setting).

PubMed ID: 23829785

Vitamin D‑fortified dairy reduced oxidative stress markers and increased antioxidant enzymes in T2DM—strong biomarker evidence of reduced oxidative/inflammatory stress.

PubMed ID: 24273887

Calcitriol increased Tregs after transplant, suggesting anti‑inflammatory immunomodulation.

PubMed ID: 23884390

Pregnancy RCT reported lower hs-CRP and improved antioxidant measures after vitamin D supplementation.

PubMed ID: 25215557

RCT in vitamin D–insufficient T2D showed robust reductions in IL-6, TNF-α and leptin with vitamin D (±calcium).

PubMed ID: 25424601

Vitamin D–fortified doogh decreased MDA and increased antioxidant capacity in T2D patients.

PubMed ID: 26119844

RCT in PCOS showed calcium+vitamin D reduced hs-CRP and oxidative-stress markers vs controls.

PubMed ID: 26401986

High-dose D3 increased anti-inflammatory IL-10 in RRMS, indicating reduced inflammatory signaling.

PubMed ID: 26659941

Topical vitamin D analog plus steroid produced rapid clinical and symptomatic improvement in psoriasis, an inflammatory skin disease.

PubMed ID: 25985241

High-dose daily D in sickle cell disease lowered PTH and improved some inflammatory/hematologic markers.

PubMed ID: 25827670

Single 200,000 IU dose in elderly women lowered hs-CRP and raised antioxidant capacity at 4 weeks.

PubMed ID: 26277548

Improved regulatory T‑cell suppressive function in new-onset T1D indicates an anti‑inflammatory/immunoregulatory effect.

PubMed ID: 26186566

ICU trial reported declines in CRP and IL‑6 over time alongside 25(OH)D normalization—suggests reduced systemic inflammation.

PubMed ID: 27720403

Calcitriol (with calcium) in NAFLD during a hypoenergetic diet improved ALT and metabolic markers—consistent with reduced hepatic inflammation/metabolic inflammation.

PubMed ID: 27488327

UC RCT: high-dose vitamin D reduced hs-CRP and ESR over 90 days — direct anti-inflammatory signal.

PubMed ID: 26811103

In NAFLD patients women receiving high-dose vitamin D had reductions in hs-CRP and improved inflammatory marker profile — direct anti-inflammatory signal (sex-specific).

PubMed ID: 28509078

Randomized trial in metabolic syndrome reported significant reductions in pro‑atherogenic inflammatory markers (IL‑6, VCAM‑1).

PubMed ID: 31874050

Vitamin D plus diet produced greater MMP‑9 reductions vs diet alone, indicating an anti‑inflammatory effect.

PubMed ID: 32917645

Adjunct tissue‑biomarker RCT: vitamin D lowered COX‑2 and improved COX‑2/15‑HPGD ratio in colorectal mucosa — clear anti-inflammatory biomarker effect.

PubMed ID: 32147032

Intramuscular megadoses in vitamin D‑deficient T2DM patients lowered CRP significantly vs control.

PubMed ID: 32141817

Single vitamin D injection decreased CD40L inflammatory gene expression in ulcerative colitis.

PubMed ID: 33176796

Repletion lowered IL‑1β and attenuated some post‑exercise inflammatory responses after 3 months.

PubMed ID: 31241441

Neonatal sepsis RCT: vitamin D reduced hs‑CRP through the treatment period.

PubMed ID: 34628889

Adjuvant vitamin D3 in Graves disease reduced TRAb and improved thyroid labs—indicative of reduced autoimmune/inflammatory activity.

PubMed ID: 34511168

Active vitamin D lowered IL‑6, IL‑17, IL‑21 and TNF‑α in children with HSP—strong RCT evidence of anti‑inflammatory effect.

PubMed ID: 36029489

Randomized trial in ESRD patients showed significant decreases in NF-κB and increases in Nrf2/antioxidant enzymes after vitamin D3—strong anti-inflammatory signal.

PubMed ID: 35281034

Transcriptome data indicate vitamin D alters immune and inflammatory gene sets (tolerogenic shift), supporting reduced inflammatory activity.

PubMed ID: 38589121

Significant reductions in CRP, ESR and ADA in vitamin D–deficient TB patients—direct anti‑inflammatory signal.

PubMed ID: 39560193

In asthma trial IL‑6/TNF‑α decreased and IL‑10 increased with adjunctive vitamin D, indicating reduced inflammation.

PubMed ID: 41145267

Calcitriol produced significant IL-6 reductions vs placebo in early diabetic kidney disease — direct anti-inflammatory biomarker effect.

PubMed ID: 40063041

High‑dose vitamin D reduced MRI inflammatory lesions in early MS, indicating reduced CNS inflammation.

PubMed ID: 31593637

Trial in type 2 diabetes reported significant decreases in TNF‑α with vitamin D (± chromium), indicating anti‑inflammatory effects.

PubMed ID: 38413933

12‑week 4000 IU/day RCT in MASLD showed increased VDR and reductions in fibrosis‑linked markers — strong surrogate evidence for reduced fibrogenic inflammation.

PubMed ID: 28841229

Single bolus before PCI reduced hs‑CRP and some secondary markers (modest anti‑inflammatory effect).

PubMed ID: 40228253

Preprocedural calcitriol significantly lowered hs‑CRP at 24h, showing an acute anti‑inflammatory signal.

PubMed ID: 38299416

Vitamin D combined with curcumin produced larger reductions in disease‑activity and inflammatory cytokines in SLE than either alone.

PubMed ID: 24968737

In NAFLD adults vitamin D lowered oxidative stress marker MDA and trended toward lower hs‑CRP (anti‑inflammatory/antioxidant signal).

PubMed ID: 36209084

T2D trial with vitamin D (±exercise) downregulated inflammatory gene expression and improved inflammatory-related biomarkers (combined intervention).

PubMed ID: 39278411

Maternal vitamin D lowered markers of intestinal and systemic inflammation in pregnancy.

PubMed ID: 23999998

High‑dose D increased regulatory T cells which are anti‑inflammatory mediators.

PubMed ID: 40644954

Multinutrient+n‑3 PUFA trial in older adults produced a modest but statistically significant reduction in an aggregated INFLA score while increasing 25(OH)D.

PubMed ID: 29288250

High‑dose vitamin D in critically ill adults lowered oxidized glutathione (GSSG), indicating reduced oxidative stress/inflammatory milieu.

PubMed ID: 35733163

Strong RCT evidence: vitamin D + aerobic training downregulated IL‑1β, TNF‑α, NF‑κB1 and improved antioxidant markers vs controls.

PubMed ID: 32441198

Randomized trial in chemo patients: combined vitamin D + omega‑3 reduced TNF‑α and IL‑1β vs controls (direct inflammatory marker reductions).

PubMed ID: 31106659

8‑week randomized colorectal cancer study: vitamin D+omega‑3 lowered CRP and TNF‑α (clear biomarker improvements, co‑supplemented).

PubMed ID: 36558465

VITAL subcohort: vitamin D produced a meaningful 19% reduction in hs-CRP at 2 years — strong inflammation marker effect.

PubMed ID: 28122931

RCT in vitamin D‑deficient T2D patients showed hs‑CRP and other inflammatory markers decreased markedly with vitamin D treatment.

PubMed ID: 30665436

Vitamin D + probiotic RCT in PCOS reduced hs‑CRP and improved oxidative stress markers (supports anti‑inflammatory effect, but co‑supplemented).

PubMed ID: 31464392

Micronutrient pack increased antioxidant enzymes and lowered MDA—biomarker evidence of reduced oxidative/inflammatory stress.

PubMed ID: 32519507

Hemodialysis RCT: increases in antioxidant enzymes and decreased MDA indicate reduced oxidative inflammation.

PubMed ID: 33508990

Endometriosis RCT: significant reductions in hs‑CRP and inflammatory/lipid markers after vitamin D—strong anti‑inflammatory signal.

PubMed ID: 35403296

T2DM RCT: vitamin D raised GSH and substantially lowered MCP‑1 and IL‑8—clear anti‑inflammatory biomarker changes.

PubMed ID: 34210242

RCT in obese women: vitamin D±magnesium reduced inflammatory markers (TNF-α, IL-6) and raised BDNF though clinical depression scores were not superior to control.

PubMed ID: 39266591

Vitamin D increased anti‑inflammatory IL‑10/TNF‑α index in a breast cancer pilot—direct inflammatory marker change.

PubMed ID: 38805039

Parkinson’s trial of probiotics+vitamin D showed robust reductions in IL‑1β, IL‑6, IFN‑γ and improved antioxidant markers; inflammation reduction was clear (though combined intervention).

PubMed ID: 38598329

Schizophrenia trial with probiotic+vitamin D significantly lowered CRP versus placebo, indicating anti-inflammatory effects of the combination.

PubMed ID: 32567290

Randomized single‑blind trial after ischemic stroke found the vitamin A+D combination strongly decreased IL‑1β and was associated with better clinical recovery.

PubMed ID: 31250540

2000 IU/day in pregnancy lowered maternal TNF-α and cord IL-6, directly demonstrating anti-inflammatory effects.

PubMed ID: 24926949

Higher/seasonal dosing in pediatric IBD associated with fewer elevated CRP and IL-6 measurements.

PubMed ID: 1583173

Calcipotriol produced clinical improvements in psoriasis (an inflammatory skin disease), consistent with anti‑inflammatory action locally.

PubMed ID: 7929921

Topical vitamin D analogue improved plaque psoriasis signs vs steroid—supports local anti‑inflammatory effect.

PubMed ID: 8021375

Adding topical calcipotriol to cyclosporine greatly increased psoriasis clearing—indirect evidence of reduced skin inflammation with vitamin D analogue.

PubMed ID: 9536226

Strong cytokine changes (IL-10 up, IL-8 down) and rapid clinical improvement indicate potent anti-inflammatory action locally.

PubMed ID: 9602870

Combination topical vitamin D+steroid yielded superior psoriasis control, reflecting reduced cutaneous inflammation.

PubMed ID: 9738781

Weekday calcipotriene reduced relapse and increased remission maintenance (reduced inflammatory activity).

PubMed ID: 9990363

Calcipotriol gave better clinical clearance and QoL vs dithranol, consistent with anti-inflammatory benefit.

PubMed ID: 10468799

Topical maxacalcitol significantly improved plaque psoriasis (anti-inflammatory effect in skin).

PubMed ID: 11234559

Calcipotriol produced marked clinical improvement in psoriasis, a primarily inflammatory skin disease (implies reduced local inflammation).

PubMed ID: 10863225

Calcipotriene plus corticosteroid produced large PASI improvements versus steroid alone, consistent with reduced skin inflammation.

PubMed ID: 12444337

Large RCT of calcipotriol+betamethasone showed greater PASI reduction vs constituents, indicating superior anti-inflammatory effect.

PubMed ID: 12125943

Topical vitamin D analogue reduced psoriasis severity (an inflammatory skin disease) when used alone or with steroid.

PubMed ID: 16316359

Paricalcitol (vit D analog) significantly reduced proteinuria in CKD, consistent with anti-inflammatory/renoprotective effects.

PubMed ID: 16600924

Vitamin D supplementation increased anti-inflammatory IL-10 and prevented TNF-α rise vs placebo.

PubMed ID: 18279409

Improved endothelial function and BP after high‑dose vitamin D2 in diabetics suggests reduced vascular inflammation/stress.

PubMed ID: 19416259

Topical vitamin D analog + steroid gave large clinical improvement in psoriasis (inflammatory skin disease).

PubMed ID: 19488999

Active vitamin D analogue preserved beta‑cell function, likely via immunomodulation/reduced autoimmune inflammation.

PubMed ID: 20653487

RCT: oral vitamin D markedly reduced atopic dermatitis severity (SCORAD), a direct anti‑inflammatory clinical effect in skin.

PubMed ID: 21293107

Topical vitamin D analogue reduced psoriasis severity (an inflammatory skin disease) when combined with steroid.

PubMed ID: 22183134

Cross-sectional associations showed lower 25(OH)D correlated with higher hsCRP and worse inflammatory/metabolic markers in T2D.

PubMed ID: 21756153

Topical vitamin D analogue plus steroid markedly improved psoriasis (inflammatory improvement).

PubMed ID: 23204220

SLE RCT showed improvements in inflammatory biomarkers—direct anti-inflammatory evidence.

PubMed ID: 23160722

Fortified yogurt intervention produced genotype-dependent reductions in hsCRP and IL‑6.

PubMed ID: 22349668

Trial in infants with heart failure showed decreases in IL‑6/TNF‑α and increases in IL‑10 with vitamin D—clear anti‑inflammatory signal.

PubMed ID: 22949664

Adjunctive vitamin D normalized immune/inflammatory markers and suppressed antigen‑stimulated proinflammatory cytokines in TB.

PubMed ID: 22395583

Daily 1600 IU improved atopic dermatitis severity — an inflammatory skin disease.

PubMed ID: 22925537

High‑dose weekly vitamin D lowered IL‑6 (anti‑inflammatory signal) though hs‑CRP paradoxically rose.

PubMed ID: 24023320

RCT showed 2000 IU/day lowered breast tissue PGE2 and COX2 expression (pro-inflammatory mediators).

PubMed ID: 23361158

Double‑blind RCT: high‑dose cholecalciferol transiently lowered MCP‑1 in CKD—robust biomarker anti‑inflammatory signal.

PubMed ID: 23414298

Topical vitamin D analogue with UVB decreased inflammatory cytokines (e.g., IL‑17) alongside clinical improvement in psoriasis — direct anti‑inflammatory signal.

PubMed ID: 25307511

Paricalcitol (vitamin D analogue) reduced albuminuria in diabetic nephropathy — albuminuria reduction can reflect lowered renal inflammation/proteinuric activity.

PubMed ID: 24622804

Adherent subgroup that became vitamin D replete experienced larger CRP decreases during weight-loss program.

PubMed ID: 24456991

Open-label RCT in prediabetes reported reduced inflammatory markers (TNFα, IL-6) alongside lower progression to diabetes.

PubMed ID: 25305352

Human prostate tissue and in vitro data: 1,25(OH)2D reduced inflammatory gene expression (PTGS2/IL‑6/IL‑8) — strong mechanistic evidence.

PubMed ID: 24572452

Alfacalcidol significantly reduced IL‑6 in obese adults — strong human evidence of anti‑inflammatory effect.

PubMed ID: 26086941

Sepsis trial: higher vitamin D doses correlated with reductions in IL‑1β and IL‑6 — direct anti‑inflammatory signal.

PubMed ID: 25801891

Double-blind RCT: 4000 IU vitamin D reduced VAS pain and markedly lowered TNF-α and PGE2 relative to placebo — strong anti-inflammatory signal.

PubMed ID: 25908506

In overweight postmenopausal women, vitamin D augmented IL‑6 reduction in those who achieved ≥5–10% weight loss — context-specific anti-inflammatory effect.

PubMed ID: 26481198

Open-label supplement in vitamin D–deficient RA patients increased 25(OH)D and produced modest disease-activity improvement — suggests inflammation reduction.

PubMed ID: 26440923

In stable CAD patients, vitamin D supplementation lowered hs‑CRP and RAAS activity alongside angiographic improvement — supports anti-inflammatory effects.

PubMed ID: 25617224

Single high-dose vitamin D decreased sputum eosinophils in an eosinophilic asthma subgroup—direct reduction in airway inflammatory cells.

PubMed ID: 25801892

SLE patients receiving monthly vitamin D showed T-cell cytokine shifts (IFN-γ/IL-4) toward Th2 and increased Tregs—indicative of reduced pro-inflammatory profile.

PubMed ID: 27161894

Vitamin D repletion in dialysis patients produced significant reductions in IL‑6 and CRP.

PubMed ID: 27363929

Diabetic foot ulcer trial showed improvements in some inflammation markers alongside wound healing.

PubMed ID: 27560161

In vitamin D–deficient acne patients, vitamin D reduced inflammatory acne lesions substantially vs placebo.

PubMed ID: 25988278

In juvenile SLE vitamin D repletion was linked to lower disease activity (an inflammatory autoimmune condition).

PubMed ID: 27147120

Significant reduction in menstrual pain (often inflammatory) after vitamin D repletion suggests anti‑inflammatory effect in this condition.

PubMed ID: 27975236

High‑dose vitamin D in Crohn's had a per‑protocol signal for fewer relapses, implying reduced intestinal inflammation.

PubMed ID: 28511692

Paricalcitol (VDR activator) significantly lowered VEGF/PDGF/IP‑10 and downregulated inflammation‑linked miRNAs.

PubMed ID: 28283863

High‑dose vitamin D in women with endometrial hyperplasia reduced hs‑CRP and improved antioxidant capacity.

PubMed ID: 28665937

Cholecalciferol reduced pro‑inflammatory receptor/cytokine expression in lymphocytes from dialysis patients, consistent with anti‑inflammatory effects.

PubMed ID: 28376103

In chronic HCV, vitamin D correction significantly reduced IP‑10 and DPP‑IV, inflammation‑related biomarkers.

PubMed ID: 28664839

Paricalcitol (vitamin D agonist) RCT significantly lowered IL‑6 and TGF‑β in proteinuric kidney transplant patients.

PubMed ID: 28827788

In hepatitis C, supplementation produced biomarker changes consistent with reduced fibrogenesis/inflammation (TGF‑β1/TIMP down, MMPs up).

PubMed ID: 28582403

Single high dose in early RA improved patient global health (clinical), consistent with reduced inflammatory burden despite no T‑cell changes.

PubMed ID: 28549923

Sustained sufficiency linked to lower joint inflammation on MRI in knee osteoarthritis cohort.

PubMed ID: 29248753

Single high dose lowered IL‑6 significantly in ventilator‑associated pneumonia—clear anti‑inflammatory signal.

PubMed ID: 28274889

Large RCT showed vitamin D reduced progression of knee effusion‑synovitis (objective MRI inflammation outcome).

PubMed ID: 28425575

Large adolescent RCT showed statistically significant reductions in hs-CRP and NLR with high-dose weekly vitamin D.

PubMed ID: 28679140

In vitamin D–deficient PCOS women, vitamin D reduced hs-CRP and oxidative stress markers in a randomized trial.

PubMed ID: 28958110

Diabetic hemodialysis patients had reductions in hs-CRP and HOMA-IR with vitamin D vs placebo.

PubMed ID: 28236223

Calcipotriol/steroid foam produced larger/faster improvements in psoriatic inflammation and QoL than gel in phase III trial.

PubMed ID: 30641712

Small RCT in diabetic nephropathy showed reductions in IL‑6 and TNF‑α after weekly high‑dose vitamin D.

PubMed ID: 30856079

T2DM patients had increased anti‑inflammatory SFRP5 and decreased pro‑inflammatory Wnt5a after 8 weeks of D3.

PubMed ID: 29466786

Supplementation reduced CIN recurrence and improved inflammatory/metabolic markers—evidence of lowering inflammation.

PubMed ID: 29738417

Randomized trial showed reductions in proinflammatory cytokines after 9 months of 1000 IU/day.

PubMed ID: 29479872

RA patients reported less pain/fatigue after supplementation, consistent with reduced inflammatory activity (clinical signals).

PubMed ID: 28994661

High‑dose supplementation reduced immune activation/exhaustion and proinflammatory monocytes in HIV+ youth.

PubMed ID: 30333271

Alfacalcidol increased IL‑10 and reduced IL‑6/IL‑10 ratio — clear anti‑inflammatory signal.

PubMed ID: 30148432

High‑dose D in deficient RA patients lowered ESR and CRP (inflammation markers).

PubMed ID: 29481636

In children with CKD, vitamin D normalized some bone/mineral markers and had differential effects on FGF23 (stage‑dependent) with inflammatory implications.

PubMed ID: 29752008

High‑dose weekly D raised 25(OH)D and altered hs‑CRP in a genotype‑dependent manner (pharmacogenetic effect on inflammation).

PubMed ID: 29661746

Monthly moderate dosing in CKD reduced CRP and improved inflammatory/metabolic markers vs high intermittent dosing.

PubMed ID: 31425951

RCT in T2DM showed large reductions in YKL-40 and MCP-1—clear anti-inflammatory effect.

PubMed ID: 31405646

4000 IU/day reduced depressive symptoms and improved some metabolic markers, consistent with lowered inflammatory state.

PubMed ID: 30800121

Supplementation decreased TNFα and IL‑6 in elderly, indicating reduced systemic inflammation.

PubMed ID: 31370809

Active vitamin D analogue (paricalcitol) reduced ICAM‑1+ microparticles—marker of endothelial activation/inflammation.

PubMed ID: 29668990

VDR activation (paricalcitol) in CKD raised soluble thrombomodulin and improved flow-mediated dilation—evidence of vascular/anti-inflammatory effect (though not nutritional vitamin D).

PubMed ID: 31624297

High-dose fortnightly vitamin D in deficient students improved inflammatory markers (IL-12 down, TAC up) alongside symptom improvement.

PubMed ID: 30871542

In mild–moderate UC, 2000 IU/day produced clinically meaningful reductions in disease activity and improved quality of life vs 1000 IU/day.

PubMed ID: 31274211

Single IM dose in UC lowered key pro‑inflammatory cytokines (TNF‑α, IFN‑γ, IL‑12p70) at 3 months.

PubMed ID: 31486158

In ventilated trauma patients vitamin D repletion reduced IL‑6/CRP/ESR and SOFA score vs control.

PubMed ID: 30696977

Hashimoto's trial showed a favorable shift in inflammatory/regulatory T-cell ratio.

PubMed ID: 31550915

Faster IL-6 decline after high-dose vitamin D in COPD exacerbations—marker of reduced inflammation.

PubMed ID: 31570180

Supplementation lowered IL-17A and raised IL-10 in asthmatics—clear anti-inflammatory immunologic change linked to lung function.

PubMed ID: 32659891

Robust RCT in T2DM showing large decreases in CRP and TNF‑α after 6 months—strong anti‑inflammatory evidence.

PubMed ID: 31926152

Vitamin D treatment in chronic urticaria lowered inflammatory cytokines and disease severity in RCT.

PubMed ID: 32345077

Active vitamin D (alfacalcidol) decreased IL‑6, hsCRP and TNF‑α and improved clinical urticaria outcomes.

PubMed ID: 32344842

Adolescent supplementation increased IL‑10 and decreased TNFR2, indicating anti‑inflammatory shifts.

PubMed ID: 32783547

In RA, vitamin D increased Tregs and reduced disease activity—consistent with reduced autoimmune inflammation.

PubMed ID: 33184146

COVID‑19 pilot lowered fibrinogen and related inflammatory signals after supplementation in deficient patients.

PubMed ID: 32485124

Single large dose in septic children produced marked reductions in IL‑6 and TNF‑α—clear anti‑inflammatory effect.

PubMed ID: 32323557

Pre‑op high‑dose vitamin D reduced myocardial apoptosis markers and raised anti‑inflammatory IL‑10—anti‑inflammatory biomarker change.

PubMed ID: 33382385

Allergic rhinitis RCT reduced IL‑4 and eosinophils and improved symptoms—direct anti‑inflammatory effects.

PubMed ID: 32203968

Weekly high‑dose vitamin D in IBS‑D reduced IL‑6 and improved symptoms (direct anti‑inflammatory signal).

PubMed ID: 32172522

Severe TBI patients treated with vitamin D showed significant TNF-α reductions and IL-6 trend downwards.

PubMed ID: 32825324

High-dose weekly vitamin D decreased IL-6 and increased IL-10 in diabetic neuropathy patients (clear anti-inflammatory signal).

PubMed ID: 31897949

2000 IU/day vitamin D3 for 12 weeks reduced migraine attacks and lowered iNOS, an inflammatory marker.

PubMed ID: 33266022

High‑dose vitamin D markedly reduced mucosal IL‑17A/IFNγ expression in Crohn's tissue (strong anti‑inflammatory signal).

PubMed ID: 32365242

Calcipotriol/betamethasone foam reduced epidermal thickness and improved clinical scores vs steroid—anti‑inflammatory effect.

PubMed ID: 32950546

Proactive use of vitamin D analogue/steroid foam reduced psoriasis relapses (chronic inflammation control).

PubMed ID: 32129954

Topical vitamin D analogue + steroid produced large rapid plaque improvement (inflammatory skin disease).

PubMed ID: 34378863

Higher‑dose ergocalciferol in dialysis patients reduced IL‑6 in those who were more deficient — targeted anti‑inflammatory effect.

PubMed ID: 34265491

Improved FMD and reductions in oxLDL and ICAM1 indicate reduced vascular inflammation in diabetic/hypertensive patients.

PubMed ID: 33060436

In paediatric IBD, vitamin D decreased ESR, CRP, fecal calprotectin and pro‑inflammatory cytokines — strong anti‑inflammatory signal.

PubMed ID: 33924645

Single pre‑race high dose reduced exercise‑induced IL‑6 and resistin increases — direct evidence of blunted inflammatory response.

PubMed ID: 34653608

Calcifediol lowered NLR and raised lymphocyte% in COVID patients — reduced systemic inflammatory marker signals.

PubMed ID: 34781136

Nano‑encapsulated vitamin D in fortified yogurt raised 25(OH)D and significantly reduced hs‑CRP and oxidative stress markers in metabolic syndrome.

PubMed ID: 33498049

Preoperative vitamin D increased anti‑inflammatory IL‑10 compared with control (biochemical anti‑inflammatory signal).

PubMed ID: 34017029

Randomized high‑dose vitamin D in COVID‑19 produced large, consistent reductions in CRP and IL‑6—strong direct anti‑inflammatory evidence in this cohort.

PubMed ID: 35720377

Repletion markedly lowered multiple proinflammatory cytokines and platelet‑immune activation markers in T2D.

PubMed ID: 35331230

Combined yoga + vitamin D increased IL‑10 and lowered IL‑6 and other inflammatory markers (small study, combined treatment).

PubMed ID: 36558461

Resistance‑training RCT showed a significant increase in IL‑10/TNF‑α ratio (improved anti‑inflammatory index) with high‑dose vitamin D.

PubMed ID: 36181990

30‑month RCT reduced hs‑CRP and uric acid along with insulin resistance — consistent anti‑inflammatory/metabolic effects.

PubMed ID: 36295519

High IM dose produced significant reductions in CRP, LDH, ferritin, D‑dimer and other inflammatory markers in hospitalized COVID patients.

PubMed ID: 35279628

In MS patients, vitamin D combined with aerobic exercise produced larger decreases in CRP, TNF‑α, IL‑6 and IL‑1β than either alone (small RCT with additive effects).

PubMed ID: 36066168

Dose-dependent reductions in amniotic NF-κB demonstrate strong anti-inflammatory effect in pregnancy.

PubMed ID: 35236423

Randomized fortification trial reported consistent, significant reductions in multiple inflammatory blood markers.

PubMed ID: 36156472

5000 IU/day in SLE reduced disease activity (inflammatory autoimmune disease) alongside rises in 25(OH)D.

PubMed ID: 35334923

Infants of vitamin‑D‑sufficient mothers had lower resting plasma TNF, indicating reduced basal inflammation.

PubMed ID: 35129441

In Crohn’s patients, supplementation reduced TNFα, IL‑17, IL‑23 and increased antioxidant enzymes—strong anti‑inflammatory signal.

PubMed ID: 34989171

Early vitamin D in preterm infants reduced CRP, IL‑6 and TNF‑α alongside lower BPD incidence.

PubMed ID: 35241369

Vitamin D during doxorubicin chemo significantly reduced IL‑6 and cardiac injury markers vs chemo alone.

PubMed ID: 36329227

High‑dose vitamin D in ICU COVID patients lowered CRP substantially by day 7.

PubMed ID: 35807783

Supplementation raised 25(OH)D and was associated with lower CRP on day 9 in hospitalized COVID‑19 patients.

PubMed ID: 36973702

Pain reduction in dysmenorrhea suggests an anti‑inflammatory mechanism in vitamin D‑deficient women.

PubMed ID: 37545122

Vitamin D in deficient schizophrenia patients lowered a kinase linked to inflammation and improved some biomarkers.

PubMed ID: 37686871

Parkinson's RCT showed decreased TNF‑α and shifts toward less neurotoxic kynurenine metabolites after 12 weeks of D3.

PubMed ID: 37198277

Vitamin D repletion lowered proinflammatory cytokines and macrophage infiltration in tonsils.

PubMed ID: 37432045

Topical vitamin D analogue (calcipotriol) markedly improved psoriasis severity, reflecting anti‑inflammatory cutaneous effects.

PubMed ID: 37716008

Adjunct vitamin D produced favorable changes in inflammatory markers in allergic rhinitis.

PubMed ID: 32828116

High‑dose vitamin D reduced urticaria severity and improved QoL, consistent with lowered skin inflammation.

PubMed ID: 36889512

Calcifediol increased IL‑10 and reduced IL‑6 in some analyses, indicating anti‑inflammatory effects.

PubMed ID: 38706151

Greater PCT decrease in high‑dose group in septic patients suggests reduced infection‑related inflammation.

PubMed ID: 38878202

Mid‑pregnancy vitamin D modestly lowered hs‑CRP (inflammation marker), especially in higher‑risk subgroups.

PubMed ID: 38479439

Downregulation of pro‑inflammatory TNF‑α/IL‑17 signaling pathways in peripheral immune cells after supplementation.

PubMed ID: 38982373

EPTB trial showed larger decreases in CRP and ESR with supplementation.

PubMed ID: 38383361

Alfacalcidol reduced pneumonia severity index particularly in high‑inflammation subgroup.

PubMed ID: 39449769

High‑dose IM vitamin D in TBI reduced IL-1β, NLR/PLR and improved outcomes.

PubMed ID: 39861434

VD3+K2 lowered multiple inflammatory biomarkers (oxLDL, sCD163, TNF‑RI) in long‑COVID.

PubMed ID: 40883693

Vitamin D reduced myofascial jaw pain (consistent with anti‑inflammatory/analgesic effects).

PubMed ID: 40310565

Fewer ARTI and fever days imply lower infectious/inflammatory burden in children.

PubMed ID: 40676542

In PBC, adjunctive vitamin D improved biochemical response and reduced liver stiffness, implying reduced hepatic inflammation/fibrosis.

PubMed ID: 39950814

Sinusitis/polyp study reported better symptom and endoscopic scores post‑operatively with vitamin D, consistent with anti‑inflammatory effect on mucosa.

PubMed ID: 40996174

Adjunctive vitamin D in Kawasaki disease produced large reductions in multiple inflammatory markers (IL‑1β, IL‑6, TNF‑α, CRP/ESR).

PubMed ID: 40139536

High‑dose vitamin D blunted obesity‑associated IL‑1β increase in pregnancy — selective anti‑inflammatory effect.

PubMed ID: 41139271

Vitamin D combined with exercise/heat reduced inflammatory markers (including myostatin) more than exercise alone in sarcopenia trial.

PubMed ID: 41525115

Clinical improvement in ventilated/septic patients after high‑dose vitamin D suggests reduced inflammatory/organ‑dysfunction burden.

PubMed ID: 40392350

Intralesional vitamin D3 (alone and with PRP) produced clear clinical, radiologic and histologic improvements in keloids — direct RCT evidence for skin benefit.

PubMed ID: 27161285

Topical Cichorium intybus (vitamin D‑like ingredient) improved TEWL and microrelief in middle‑aged women; relevant to skin barrier/appearance though not oral vitamin D.

PubMed ID: 40135774

Local vitamin D injections produced modest short‑term improvements in keloid/hypertrophic scar softness and redness.

PubMed ID: 26659941

Topical vitamin D analogue (calcipotriene) plus steroid produced rapid and large improvements in psoriasis lesions and itch.

PubMed ID: 17373972

Topical calcitriol was non-inferior to calcipotriol for psoriasis with fewer local side effects—robust evidence supporting topical vitamin D analog benefit for skin disease.

PubMed ID: 17668541

Large RCT showed topical calcitriol (vitamin D3 analog) was significantly more effective than vehicle for plaque psoriasis with good safety—direct, strong evidence for skin benefit.

PubMed ID: 16487090

Topical vitamin D analogue (tacalcitol) added to narrow‑band UVB improved repigmentation in vitiligo vs UVB alone—direct dermatologic benefit.

PubMed ID: 14968327

Topical tacalcitol (vitamin D analogue) produced large clinical improvement in scalp psoriasis without systemic calcium effects.

PubMed ID: 14521705

Topical calcipotriol (vitamin D analog) produced faster and greater improvement in plaque psoriasis versus coal tar.

PubMed ID: 12037450

High‑dose topical calcipotriol (vitamin D analog) substantially improved psoriasis severity with no systemic vitamin D disturbances — direct skin benefit.

PubMed ID: 11260005

Topical calcitriol combined with UVB improved PASI score and reduced UVB exposure versus vehicle, demonstrating strong skin benefit.

PubMed ID: 9039301

Topical calcipotriol performed similarly to steroid cream, reducing PASI and lesion thickness without systemic calcium effects.

PubMed ID: 8609254

Topical calcipotriene effective for psoriasis with no systemic calcium/bone issues — robust topical effect.

PubMed ID: 7822519

Topical calcipotriene produced large psoriasis improvements vs vehicle with minimal lab effects—strong dermatologic evidence.

PubMed ID: 7741542

Topical calcipotriol (vitamin D3 analogue) moderately improved several ichthyoses with little systemic calcium change—direct skin benefit.

PubMed ID: 7999599

Topical calcipotriol produced clear clinical improvement in psoriasis with minimal systemic calciotropic change—direct skin benefit.

PubMed ID: 8252786

Occlusion substantially increased topical calcipotriol efficacy for psoriasis without systemic calcium changes—clear topical skin benefit.

PubMed ID: 8504051

Topical calcitriol improved psoriasis plaques with meaningful clearance vs vehicle; some systemic hypercalcemia in a few patients indicates occasional absorption risk.

PubMed ID: 7904106

Short-term topical calcipotriol improved lesions but produced no systemic biochemical changes—supports topical skin efficacy.

PubMed ID: 1390171

Large randomized trial: topical calcipotriol cleared psoriasis better than comparator—strong direct evidence for skin benefit.

PubMed ID: 1670840

Topical vitamin D analogue (calcipotriol) was superior to steroid cream for psoriasis clearance in a large randomized trial.

PubMed ID: 22515652

Topical vitamin D analogue improved scalp psoriasis markedly, especially with longer combination steroid pre‑treatment.

PubMed ID: 9892908

Large multicenter RCT: combining topical vitamin D analogue with corticosteroid improved psoriasis severity and reduced irritation vs vitD alone.

PubMed ID: 8949429

Topical vitamin D analogue (calcipotriol) clearly reduced keratinocyte proliferation and inflammatory cells in psoriasis.

PubMed ID: 29399865

Randomized trial: 5000 IU/day cholecalciferol improved rhododendrol‑induced vitiligo vs control with correlated rises in 25(OH)D.

PubMed ID: 27995521

Topical vitamin D analogue (calcipotriol) plus steroid outperformed comparator in psoriasis (direct skin benefit).

PubMed ID: 9292072

Topical calcitriol/analogues caused dose‑dependent mild irritation and increased blood flow without disrupting barrier—direct cutaneous effects.

PubMed ID: 12588386

Topical vitamin D analog (calcipotriol) used with methotrexate reduced required MTX dose and prolonged relapse‑free interval in psoriasis.

PubMed ID: 9390335

Tacalcitol once‑daily reduced psoriasis symptoms comparably to calcipotriol; safe regarding serum calcium.

PubMed ID: 9039169

Calcipotriol ointment reduced redness and scaling in children with mild psoriasis and was systemically safe.

PubMed ID: 8977677

Tacalcitol ointment markedly improved psoriasis signs without systemic calcium/vitamin D changes — strong dermatologic effect.

PubMed ID: 35124915

Intralesional vitamin D3 was more effective than cryotherapy for clearing cutaneous warts in a randomized trial (direct dermatologic benefit).

PubMed ID: 34213957

High‑dose vitamin D increased healed diabetic foot ulcers and reduced ulcer area vs low‑dose — direct improvement in skin/wound healing.

PubMed ID: 32430142

Pooled analysis confirms sensitivity of scores to detect Cal/BD foam responses (supports skin benefit evidence base).

PubMed ID: 32129954

Calcipotriene/betamethasone foam produced large rapid improvements in plaque characteristics vs vehicle.

PubMed ID: 32950546

Proactive twice‑weekly use of Cal/BD foam prolonged remission and reduced relapses in psoriasis (topical vit D analogue).

PubMed ID: 32365242

Cal/BD foam (vit D analogue + steroid) cleared plaque psoriasis faster and more effectively vs clobetasol.

PubMed ID: 32162438

RCT: intralesional vitamin D3 produced ~63% complete clearance of plantar warts (better than placebo).

PubMed ID: 32681688

Intralesional vitamin D3 cleared multiple warts in children with high complete clearance rates.

PubMed ID: 32866634

Intralesional vitamin D3 achieved high complete clearance of recalcitrant palmoplantar warts (strong dermatologic effect).

PubMed ID: 32064596

Topical calcitriol added to rapamycin improved and prolonged clearance of facial angiofibromas (cutaneous lesion improvement).

PubMed ID: 33052103

Topical vitamin D analog (calcipotriol) combined with steroid showed superior efficacy/tolerability for scalp psoriasis (direct dermatologic benefit).

PubMed ID: 32892493

Intralesional vitamin D3 cleared plantar warts better than placebo/PPD with no recurrences (direct skin therapeutic effect).

PubMed ID: 31868550

Active vitamin D analog improved acne severity in a randomized study (direct dermatologic benefit).

PubMed ID: 32345077

Active vitamin D (alfacalcidol) improved chronic spontaneous urticaria and lowered IL‑6/hsCRP/TNFα.

PubMed ID: 31926152

Vitamin D treatment in chronic urticaria significantly reduced disease severity (UAS7) and inflammatory cytokines—direct skin‑disease benefit.

PubMed ID: 33010974

In PCOS overweight women, high‑dose vitamin D lowered hirsutism scores—improvement in hair/skin condition.

PubMed ID: 33145984

Oral vitamin D improved severe atopic dermatitis severity (EASI) in children—clear systemic skin benefit.

PubMed ID: 30895944

Topical vitamin D analog plus 5-FU markedly reduced SCC incidence and increased tissue-resident memory T cells—strong dermatologic benefit.

PubMed ID: 31236672

Topical vitamin D analog and UVB improved alopecia areata (hair/skin appendage) scores and raised serum vitamin D.

PubMed ID: 30204734

Correction of vitamin D deficiency before scar revision associated with decreased hypertrophic scarring and reduced scar width—direct skin healing benefit.

PubMed ID: 29419896

Calcipotriol+clobetasol ointment effective for palmoplantar psoriasis—topical vitamin D analog contributed to skin lesion improvement.

PubMed ID: 29952297

Large Phase III trial: calcipotriol-containing foam improved psoriasis symptoms and QoL—strong topical vitamin D analog skin benefit.

PubMed ID: 30238557

Raising 25(OH)D to ≥20 ng/mL alongside topical therapy associated with significantly lower atopic dermatitis (SCORAD) and remission in some patients.

PubMed ID: 28301043

Adherence/education program improved short‑term response to topical calcipotriol/betamethasone in psoriasis (topical vitamin D analogue).

PubMed ID: 28236223

Topical calcipotriol/steroid foam (vitamin D analogue) produced large, clinically meaningful reductions in psoriasis severity and BSA in a phase III trial.

PubMed ID: 27537999

Combination topical improved skin‑related quality of life substantially vs vehicle after 4 weeks.

PubMed ID: 27531752

Large trial: calcipotriol+betamethasone aerosol foam superior to gel for psoriasis clearance (combination product efficacy).

PubMed ID: 27537995

Calcipotriene (vitamin D analogue) + steroid aerosol foam produced faster and greater psoriasis clearance and itch relief.

PubMed ID: 27001565

Lower circulating vitamin D associated with worse melanoma‑specific survival (prospective) — observational link between vitamin D status and skin cancer outcomes.

PubMed ID: 27560161

Vitamin D reduced inflammatory acne lesion counts in deficient patients—direct dermatologic benefit.

PubMed ID: 27363929

Improved wound healing in diabetic foot ulcers indicates skin/tissue repair benefit.

PubMed ID: 27869649

Topical calcipotriol + 5‑FU dramatically cleared actinic keratoses and activated local immune responses—robust dermatologic result.

PubMed ID: 26731976

Spa balneotherapy + topical vitamin D3 analogue produced greater short‑term improvements in plaque psoriasis than topical alone.

PubMed ID: 26444907

Large RCT: calcipotriol (vitamin D analogue) + betamethasone aerosol foam produced superior psoriasis clearance—strong skin benefit (topical agent).

PubMed ID: 26358764

Topical vitamin D analogue + steroid improved vitiligo lesions (repigmentation) in a small trial.

PubMed ID: 26282062

Topical vitamin D analog (maxacalcitol) significantly improved palmoplantar pustulosis scores in a randomized trial—strong topical skin benefit.

PubMed ID: 25346093

Large trial: topical calcipotriol/betamethasone gel (vitamin D analogue) produced clear/almost‑clear skin in ~1/3 of psoriasis patients — strong topical evidence.

PubMed ID: 25377657

Randomized study: daily low‑dose UV (which raised vitamin D) improved psoriasis severity and QoL vs steroid alone—clinical skin benefit though UV confounds attribution to vitamin D alone.

PubMed ID: 25282565

Randomized double-blind trial: one month of daily vitamin D modestly but significantly improved winter-related eczema severity in deficient Mongolian children.

PubMed ID: 23414298

Topical vitamin D analogue plus NB‑UVB cleared psoriasis fastest and reduced inflammatory cytokines — skin disease and mechanism evidence.

PubMed ID: 23377334

Large RCT: calcipotriene (vitamin D analogue) + betamethasone more effective than components/vehicle for body psoriasis — strong topical vitamin D evidence.

PubMed ID: 24256460

Betamethasone dressing non‑inferior to calcipotriol–betamethasone ointment — calcipotriol contributes to topical psoriasis efficacy.

PubMed ID: 23621170

Calcipotriol/betamethasone gel improved scalp psoriasis and maintenance reduced relapse — supports sustained skin benefit.

PubMed ID: 23545912

Large RCT: calcipotriene foam significantly improved scalp psoriasis vs vehicle with benefits from week 2 — robust skin benefit.

PubMed ID: 23986159

Topical calcipotriol (vitamin D analogue) produced quicker and larger PASI improvements and fewer relapses vs coal tar — strong dermatologic evidence.

PubMed ID: 23441902

Randomized trial: topical calcipotriol (vit D analogue) + NB‑UVB significantly improved repigmentation in vitiligo—strong dermatologic benefit.

PubMed ID: 22515588

Calcipotriol added to targeted UVB produced greater psoriasis improvements versus UVB alone in a randomized trial.

PubMed ID: 23112909

Topical vitamin D3 improved clinical and patient-assessed skin dryness in vitamin D–insufficient subjects (split-leg RCT).

PubMed ID: 22587791

Topical vitamin D analog (calcipotriene) showed modest but significant benefit in plaque psoriasis trials.

PubMed ID: 22395583

1600 IU/day improved atopic dermatitis severity vs placebo in an RCT.

PubMed ID: 20456557

Topical calcipotriol+betamethasone combination cleared scalp psoriasis faster than components alone (large RCT).

PubMed ID: 21756153

Topical vitamin D analogue added to systemic therapy markedly improved psoriasis outcomes (PASI75 87% vs 37%).

PubMed ID: 21293107

Topical vitamin D analog (with steroid) produced clear clinical improvement in psoriasis (~40% clear/almost clear at 8 weeks).

PubMed ID: 20684147

Long‑term safety RCT showed topical calcipotriene/betamethasone ointment did not cause HPA‑axis suppression—relevant to dermatologic safety.

PubMed ID: 20964660

Topical calcipotriene (vit D analogue) + steroid scalp gel was highly effective for scalp psoriasis in a randomized trial.

PubMed ID: 20413372

Randomized double‑blind trial: topical calcipotriol (vitamin D analogue) + steroid gel significantly improved psoriasis vs components or vehicle.

PubMed ID: 20377585

Topical calcipotriol/betamethasone added to adalimumab sped early psoriasis improvement — topical vitamin D analogue contributed to faster skin response.

PubMed ID: 20653487

Oral vitamin D improved atopic dermatitis severity strongly in an RCT — direct benefit for inflammatory skin disease.

PubMed ID: 19453810

Combination topical improved QoL and skin disease measures for scalp psoriasis patients.

PubMed ID: 19416259

Topical vitamin D analog (with steroid) markedly improved scalp psoriasis outcomes vs calcipotriol alone — strong dermatologic evidence.

PubMed ID: 18463448

Phase II trial: calcipotriol+betamethasone improved scalp psoriasis more than steroid alone — clinically meaningful.

PubMed ID: 8746336

Topical calcitriol cleared or improved psoriasis in most patients with no systemic calcium effects — strong skin benefit.

PubMed ID: 18787325

One‑year study showed combination calcipotriol+betamethasone safer and better controlled psoriasis than calcipotriol alone (large sample, clear benefit).

PubMed ID: 19067709

Large RCT: calcipotriol (vitamin D analogue)+betamethasone cleared scalp psoriasis far better than calcipotriol alone — strong dermatologic benefit.

PubMed ID: 18694678

Topical calcipotriene+betamethasone provided superior scalp psoriasis clearance (large effect, RCT).

PubMed ID: 17596167

Topical becocalcidiol cleared or almost cleared psoriasis in ~26% of patients vs vehicle (RCT topical vitamin D analogue).

PubMed ID: 17934937

Calcipotriol plus steroid ointment worked faster and better for psoriasis than calcipotriol alone.

PubMed ID: 18067483

Topical calcipotriol improved dermatology‑specific QoL similarly to dithranol (patient‑friendly topical D‑analogue).

PubMed ID: 17935517

Topical calcitriol helped psoriasis modestly though with more local erythema vs tacrolimus.

PubMed ID: 16704648

One‑year safety data for calcipotriol/betamethasone showed acceptable safety profile for chronic topical use.

PubMed ID: 16734505

Large randomized trial: calcipotriene maintenance produced significant PASI improvement vs vehicle.

PubMed ID: 17100739

Tacalcitol enhanced excimer light efficacy for vitiligo — improved skin repigmentation and treatment efficiency.

PubMed ID: 16585986

Calcipotriol performed similarly to tacrolimus for plaque psoriasis with fewer burning reactions — clinically relevant.

PubMed ID: 17010744

Combination topical vitamin D analogue + clobetasol gave better short‑term plaque psoriasis outcomes and trends for maintenance.

PubMed ID: 16503885

Topical vitamin D analogue + steroid accelerated repigmentation in localized vitiligo — relevant to skin repair.

PubMed ID: 17135738

Large trial: continuous calcipotriol/betamethasone tended to give better long‑term psoriasis control than calcipotriol alone.

PubMed ID: 16684279

Biopsy data showed calcipotriol induced molecular changes consistent with therapeutic effects in psoriasis.

PubMed ID: 16965431

Topical calcipotriol substantially reduced psoriasis severity and caused fewer skin application problems than comparator.

PubMed ID: 16983001

Calcipotriol markedly reduced intertriginous psoriasis severity and itch (randomized, double-blind).

PubMed ID: 16425972

Combination of calcipotriol with UV phototherapy improved psoriasis more than ointment alone.

PubMed ID: 15701591

Topical calcipotriol/steroid largely improved psoriasis in older patients with few local side effects.

PubMed ID: 15897165

Calcipotriol effective but less so and less tolerated than steroid shampoo for scalp psoriasis.

PubMed ID: 15539894

Calcipotriol+betamethasone regimen yielded substantially greater PASI reductions than comparator.

PubMed ID: 15204160

Calcipotriol+PUVA produced major PASI improvement and UVA-sparing effects — strong topical vitamin D analogue benefit.

PubMed ID: 41265876

Topical vitamin D analogue cleared palmoplantar warts comparably to cryotherapy with far fewer adverse effects—direct skin benefit.

PubMed ID: 39878244

Topical calcipotriol added to steroid modestly improved scalp alopecia areata and reduced steroid atrophy — direct dermatologic benefit (analogue).

PubMed ID: 40457259

Adjunctive oral vitamin D plus steroids reduced pain and lesion severity in oral lichen planus, a mucocutaneous inflammatory condition.

PubMed ID: 40633744

High‑dose oral vitamin D before PDT significantly hastened clearance of thin skin cancers.

PubMed ID: 37925677

Topical vitamin D analogue reduced acne lesions vs placebo (split-face RCT).

PubMed ID: 38770629

Vernal keratoconjunctivitis improved after repletion; ocular surface/skin-adjacent benefit.

PubMed ID: 39020381

Oral lichen planus improvement (oral mucosal/skin domain) with reduced IFN-γ.

PubMed ID: 39262166

Intralesional vitamin D reduced keloid scar scores with fewer steroid‑type adverse effects (though less effective than triamcinolone).

PubMed ID: 38272820

Topical/oral vitamin D improved chloasma severity, wound healing and skin barrier metrics in a large cohort — clear dermatologic benefit.

PubMed ID: 36762396

Topical vitamin D3 added to microneedling improved hair regrowth in localized alopecia areata.

PubMed ID: 36606379

Intralesional vitamin D3 produced wart clearance in a substantial fraction of patients.

PubMed ID: 32828116

High‑dose vitamin D improved chronic urticaria symptoms and quality of life.

PubMed ID: 37432045

Phase 3 RCT of a topical vitamin D analogue showed large, clinically meaningful improvements in psoriasis severity and QoL.

PubMed ID: 35254765

Large pooled trial: calcipotriol (vitamin D analog) + steroid cream improved psoriasis outcomes and dermatology QOL.

PubMed ID: 35730342

Topical calcipotriol + urea improved nail psoriasis more than comparators with mild side effects.

PubMed ID: 36088627

Intralesional vitamin D3 cleared warts in ~54% of patients, a direct dermatologic benefit.

PubMed ID: 36054319

Topical calcipotriol (vitamin D analogue) + steroid produced the largest improvement in psoriasis lesions and reduced skin CD8+ T cells/neutrophils.

PubMed ID: 36575890

Topical vitamin D analogue plus steroid worked comparably to a superpotent steroid for localized alopecia areata (skin/hair outcome).

PubMed ID: 35870076

A personalized sun‑exposure app reduced erythema (sunburn) without lowering vitamin D—behavioral skin benefit demonstrated.

PubMed ID: 35314199

High-dose oral vitamin D pre-PDT significantly increased clearance of facial actinic keratoses (direct skin benefit).

PubMed ID: 35152536

Intralesional vitamin D3 RCT produced significant hair regrowth in alopecia areata — strong dermatologic benefit.

PubMed ID: 35763390

Maternal supplementation reduced infant eczema at 12 months—important pediatric skin outcome.

PubMed ID: 33852252

Large open‑label study: calcipotriene/betamethasone foam produced rapid, substantial clearing in psoriasis—topical vitamin D analog efficacy.

PubMed ID: 33852251

Large phase‑3 RCT: calcipotriene (vitamin D analog) + betamethasone cream produced superior psoriasis clearance—strong topical vitamin D analog evidence for skin benefit.

PubMed ID: 15129317

Topical vitamin D analog added to systemic cyclosporin improved nail psoriasis vs cyclosporin alone.

PubMed ID: 15214905

Large randomized trial showed topical calcipotriol+betamethasone gave faster/larger clearing and fewer local ADRs vs calcipotriol alone.

PubMed ID: 15377355

Topical calcipotriol combined with steroid improved QoL and psoriasis severity versus vehicle and often better than calcipotriol alone.

PubMed ID: 12948920

Premixed calcipotriol+clobetasol worked faster and caused fewer side effects than calcipotriol alone for scalp psoriasis.

PubMed ID: 12814339

Topical calcipotriol plus oral acitretin improved clearance rates relative to acitretin alone.

PubMed ID: 12522370

Calcipotriene plus betamethasone fixed combo produced the largest PASI reductions vs single agents, demonstrating strong topical benefit.

PubMed ID: 12804986

Calcitriol maintenance regimen was as effective and safe as calcipotriol-based regimen for plaque psoriasis.

PubMed ID: 12588387

Calcitriol was as effective as calcipotriol for plaque psoriasis but caused less local irritation.

PubMed ID: 12745849

Topical calcitriol produced similar clearance to steroid but longer remissions in many patients.

PubMed ID: 12920367

Topical vitamin D analogue combined with steroid was well tolerated and produced similar skin thinning as steroid alone (safety data).

PubMed ID: 12890208

Calcipotriol + TL01 UVB reduced UVB dose and accelerated PASI improvement.

PubMed ID: 12932242

Calcipotriol cleared psoriasis plaques comparably to coal tar with better tolerability.

PubMed ID: 12218286

Topical calcipotriol added to dithranol sped and improved psoriasis clearing.

PubMed ID: 12366423

Tacalcitol plus PUVA cleared psoriasis faster and reduced UVA exposure vs PUVA alone.

PubMed ID: 12125943

Large randomized trial: topical calcipotriol (vitamin D analogue) + steroid produced markedly greater and faster psoriasis improvement.

PubMed ID: 12444337

Large RCT: once-daily calcipotriol+betamethasone was more effective than either ingredient alone for psoriasis (substantial effect size reported).

PubMed ID: 11447774

Calcipotriol (occlusive and nonocclusive) both markedly improved palmoplantar psoriasis signs (~75% mean score reduction).

PubMed ID: 11531839

Topical calcipotriol with PUVA increased and accelerated repigmentation in vitiligo with lower UVA exposure.

PubMed ID: 11053917

Topical calcitriol treated plaque psoriasis as effectively as dithranol but with far less irritation and better acceptability.

PubMed ID: 11314240

Topical calcipotriol was similarly effective to betamethasone for scalp psoriasis over 6 weeks.

PubMed ID: 10863225

Randomized trial: calcipotriene plus steroid produced much greater clearance than steroid alone—strong skin benefit.

PubMed ID: 11234559

Topical calcipotriol markedly improved plaque psoriasis PASI (~67% reduction) and was well tolerated—strong direct skin benefit.

PubMed ID: 10468799

Topical maxacalcitol significantly improved plaque psoriasis vs placebo and compared well with calcipotriol.

PubMed ID: 10490297

Calcipotriol plus UVB produced faster psoriasis improvement than either alone.

PubMed ID: 9731961

Steroid induction followed by calcipotriol improved lesion scores more than calcipotriol alone.

PubMed ID: 9990363

Calcipotriol produced higher clearance rates and better QoL vs dithranol for psoriasis (skin health benefit).