Ashwagandha
18 benefits mapped to clinical evidence across supplements.
Dose per serving from products
1,468 products in our catalogue print how much Ashwagandha a serving holds.
Most common: 100 mg to 250 mg, 26% of 1,468 products.
| Dose per serving | Products |
|---|---|
| 25 mg or less | 73 |
| 25 mg to 50 mg | 149 |
| 50 mg to 100 mg | 372 |
| 100 mg to 250 mg | 383 |
| 250 mg to 500 mg | 312 |
| 500 mg to 1 g | 96 |
| 1 g to 2.5 g | 60 |
| over 2.5 g | 23 |
Dose per serving from research
42 study groups in 36 studies say how much Ashwagandha participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mg to 1 g, 48% of 42 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mg to 250 mg | 9 |
| 250 mg to 500 mg | 11 |
| 500 mg to 1 g | 20 |
| over 1 g | 2 |
Benefit Evidence
Research sources
Wellbeing (14)
- Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial
PubMed ID: 27055824
Stressed adults reported reductions in perceived stress, cravings and cortisol with modest weight/BMI benefits, improving QoL.
- Adjunctive Use of a Standardized Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 29995356
Adjunctive trial reported improved perceived stress and clinically meaningful reductions in negative/total symptoms, reflecting enhanced well‑being.
- A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults
PubMed ID: 32540634
Large sleep RCT showed major improvements in restorative sleep and subjective sleep quality, which commonly enhances overall well‑being.
- Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study
PubMed ID: 34553463
Perimenopausal RCT produced marked symptom and QoL improvements alongside hormone changes.
- The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial
PubMed ID: 35984870
Qualitative RCT participants reported improved perceived well‑being, sleep and clearer thinking.
- Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial
PubMed ID: 37740662
Reduced fatigue, improved HRV and increased free testosterone (men) contribute to overall well‑being.
- A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study
PubMed ID: 37832082
Large PSS decrease, cortisol reduction and serotonin increase in randomized trial — clear improvement in well‑being markers.
- A Standardized Withania somnifera (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 37878284
90‑day RCT improved depression/anxiety scores and increased serotonin — strong well‑being signal.
- Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
PubMed ID: 38732539
Dose‑response improvements in stress, cortisol and inflammatory markers support broad well‑being benefits.
- Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood
PubMed ID: 38931168
Objective cognitive and mood improvements support better day‑to‑day well‑being.
- Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study
PubMed ID: 39498904
Cognitive, mood and fatigue improvements across validated scales support enhanced well‑being.
- Effects of Root Extract of Ashwagandha (Withania somnifera) on Perception of Recovery and Muscle Strength in Female Athletes
PubMed ID: 39954269
Athlete trial showed better recovery, sleep and subjective readiness, contributing to well‑being.
- Efficacy and safety of Ashwagandha (Withania somnifera) root extract on stress and weight management in adults: a prospective, randomized, double-blind, placebo-controlled study
PubMed ID: 41635453
24‑week RCT showed improvements in BMI, stress and cortisol — meaningful effects on health/well‑being.
- A New Ashwagandha Formulation (Zenroot™) Alleviates Stress and Anxiety Symptoms While Improving Mood and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Clinical Study
PubMed ID: 40875185
Zenroot™ 12‑week RCT improved stress, sleep and HRV — multimodal well‑being benefits.
Stress & Anxiety (12)
- Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial
PubMed ID: 27055824
8‑week RCT in stressed adults showed significant reductions in perceived stress and serum cortisol versus placebo.
- Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
PubMed ID: 38732539
Large dose‑response RCT showed dose‑dependent reductions in PSS, cortisol/ACTH and salivary α‑amylase.
- A Standardized Withania somnifera (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 37878284
90‑day RCT produced significant decreases in Hamilton Anxiety scores vs placebo.
- A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study
PubMed ID: 37832082
60‑day RCT produced large PSS reduction and decreased morning cortisol (biomarker‑confirmed effect).
- Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial
PubMed ID: 37740662
PSS decreased markedly from baseline but not significantly more than placebo due to strong placebo response.
- Assessment of the Efficacy of Withania somnifera Root Extract in Patients with Generalized Anxiety Disorder: A Randomized Double-blind Placebo- Controlled Trial
PubMed ID: 32282308
Randomized double‑blind adjunctive trial in GAD showed marked HAM‑A reductions with ashwagandha adjunct vs placebo.
- Adjunctive Use of a Standardized Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 29995356
Adjunctive trial reported improved perceived stress (PSS) with ashwagandha versus placebo.
- An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study
PubMed ID: 31517876
240 mg/day RCT produced large anxiolytic effect (HAM‑A) and cortisol reduction in mildly stressed adults.
- Evaluation of the efficacy of Withania somnifera (Ashwagandha) root extract in patients with obsessive-compulsive disorder: A randomized double-blind placebo-controlled trial
PubMed ID: 27515872
Adjunctive OCD pilot showed substantial Y‑BOCS reduction versus placebo; OCD is anxiety‑spectrum, indicating anxiolytic potential.
- Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study
PubMed ID: 39498904
Cognitive and mood improvements on validated scales indicate reduced psychological distress.
- Efficacy and safety of Ashwagandha (Withania somnifera) root extract on stress and weight management in adults: a prospective, randomized, double-blind, placebo-controlled study
PubMed ID: 41635453
24‑week RCT showed meaningful PSS reductions and serum cortisol decreases vs placebo.
- A New Ashwagandha Formulation (Zenroot™) Alleviates Stress and Anxiety Symptoms While Improving Mood and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Clinical Study
PubMed ID: 40875185
12‑week RCT (Zenroot™) significantly reduced PSS and increased HRV vs placebo.
Energy & Fatigue (9)
- Ashwagandha Root Extract Stabilises Physiological Stress Responses in Male and Female Team Sports Athletes During Pre-Season Training
PubMed ID: 41599843
Pre‑season trial stabilised cortisol and improved perceived recovery in females (supports less fatigue).
- Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study
PubMed ID: 32818573
Ashwagandha improved sleep metrics (better sleep commonly reduces daytime fatigue); effect stronger in insomnia subgroup.
- A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults
PubMed ID: 32540634
Actigraphy‑verified improvements in sleep efficiency and total sleep time argue for clinically meaningful reductions in fatigue.
- The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial
PubMed ID: 35984870
Qualitative RCT participants reported more sustained energy during 30‑day trial.
- Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial
PubMed ID: 37740662
12‑week RCT showed significant reduction in fatigue (CFS) vs placebo.
- A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study
PubMed ID: 37832082
60‑day RCT showed lower perceived stress and cortisol which often correlate with reduced fatigue.
- Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood
PubMed ID: 38931168
Acute and 30‑day controlled study reported reduced tension/fatigue on POMS.
- Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study
PubMed ID: 39498904
8‑week RCT found reduced mental fatigue and improved energy/mood scores.
- Effects of Root Extract of Ashwagandha (Withania somnifera) on Perception of Recovery and Muscle Strength in Female Athletes
PubMed ID: 39954269
28‑day trial in athletes improved perceived recovery and sleep (less fatigue subjectively).
Mood balance (9)
- A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study
PubMed ID: 37832082
60‑day RCT lowered PSS, cortisol and increased urinary serotonin — mood‑relevant biomarkers and scores.
- A Standardized Withania somnifera (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 37878284
90‑day RCT produced clinically relevant reductions in depression and anxiety scores with increased serum serotonin.
- Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood
PubMed ID: 38931168
Acute and 30‑day study showed decreases in tension and fatigue on POMS.
- Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study
PubMed ID: 39498904
8‑week RCT improved POMS‑A and measures of mood and executive function.
- Efficacy and safety of Ashwagandha (Withania somnifera) root extract on stress and weight management in adults: a prospective, randomized, double-blind, placebo-controlled study
PubMed ID: 41635453
24‑week RCT substantially reduced perceived stress (PSS), contributing to improved overall mood/well‑being.
- Evaluation of the efficacy of Withania somnifera (Ashwagandha) root extract in patients with obsessive-compulsive disorder: A randomized double-blind placebo-controlled trial
PubMed ID: 27515872
Adjunctive W. somnifera produced substantial Y‑BOCS reductions (OCD) consistent with large symptomatic mood/affect benefit in small pilot.
- Adjunctive Use of a Standardized Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 29995356
Adjunct to antipsychotics reduced perceived stress and PANSS negative/total symptoms, indicating mood/affect improvements.
- An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study
PubMed ID: 31517876
Reduced HAM‑A and cortisol in mildly stressed adults; mood/anxiety effects evident in RCT.
- Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study
PubMed ID: 34553463
Perimenopausal trial reduced climacteric symptoms and improved QoL scores, reflecting mood/quality‑of‑life benefits.
Illness recovery (8)
- Comparative study of effect of Withania somnifera as an adjuvant to DOTS in patients of newly diagnosed sputum smear positive pulmonary tuberculosis
PubMed ID: 29933868
Adjunctive use in TB showed faster sputum conversion (clinical recovery marker) versus placebo.
- A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults
PubMed ID: 33600918
Athletic trial documented improved Total Quality Recovery (TQR) and recovery questionnaire scores versus placebo.
- Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers
PubMed ID: 36419388
Polyherbal COVID trial (includes Withania) reported shorter illness duration and milder symptoms vs placebo (faster recovery signal).
- Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial
PubMed ID: 37740662
12‑week trial reduced fatigue and improved HRV, which can reflect improved recovery capacity.
- Effects of Ashwagandha ( Withania somnifera) standardized root extract on physical endurance and VO (2max) in healthy adults performing resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study
PubMed ID: 38988644
8‑week resistance‑training RCT enhanced strength, VO2max and muscle size — supports faster training adaptations/recovery.
- Ashwagandha (Withania somnifera) and Shunthi (Zingiber officinale) in mild and moderate COVID-19: An open-label randomized controlled exploratory trial
PubMed ID: 37482107
Open‑label Ayurvedic regimen shortened clinical recovery time in COVID (multi‑herb; exploratory).
- Effects of Root Extract of Ashwagandha (Withania somnifera) on Perception of Recovery and Muscle Strength in Female Athletes
PubMed ID: 39954269
28‑day RCT in female footballers improved perceived recovery and sleep (direct recovery outcome).
- Ashwagandha Root Extract Stabilises Physiological Stress Responses in Male and Female Team Sports Athletes During Pre-Season Training
PubMed ID: 41599843
42‑day trial in athletes stabilised cortisol/cortisone and improved female perceived recovery and male CMJ performance.
Hormone balance (8)
- Ashwagandha Root Extract Stabilises Physiological Stress Responses in Male and Female Team Sports Athletes During Pre-Season Training
PubMed ID: 41599843
Pre‑season trial stabilised evening salivary cortisol/cortisone during training (preventing rises seen in placebo).
- Efficacy and safety of Ashwagandha (Withania somnifera) root extract on stress and weight management in adults: a prospective, randomized, double-blind, placebo-controlled study
PubMed ID: 41635453
24‑week trial lowered serum cortisol along with BMI and PSS, supporting improved HPA‑axis hormonal balance.
- A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males
PubMed ID: 30854916
Crossover study raised DHEA‑S and testosterone in overweight men, indicating endocrine modulation.
- Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study
PubMed ID: 34553463
Perimenopausal RCT produced favorable increases in estradiol and decreases in FSH/LH with symptom improvement.
- Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial
PubMed ID: 37740662
Raised free testosterone in men indicates a hormone‑modulatory effect.
- A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study
PubMed ID: 37832082
60‑day RCT produced significant morning cortisol reductions and increased serotonin.
- Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
PubMed ID: 38732539
Dose‑response RCT lowered cortisol and ACTH along with stress improvements.
- Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial
PubMed ID: 28829155
8‑week RCT in subclinical hypothyroidism showed significant normalization of TSH, T3 and T4 versus placebo.
Sleep quality (7)
- Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study
PubMed ID: 32818573
8‑week RCT demonstrated significant improvements in sleep onset latency, sleep efficiency and total sleep time, especially in insomnia patients.
- The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial
PubMed ID: 35984870
Qualitative analysis of RCT participants reported improved sleep quality subjectively.
- The Impact of Ashwagandha on Stress, Sleep Quality, and Food Cravings in College Students: Quantitative Analysis of a Double-Blind Randomized Control Trial
PubMed ID: 35984871
30‑day double‑blind RCT showed significant improvement in restorative sleep scores vs placebo.
- A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study
PubMed ID: 37832082
60‑day RCT demonstrated improved perceived stress and lowered morning cortisol and increased serotonin — effects aligned with better sleep.
- Effects of Root Extract of Ashwagandha (Withania somnifera) on Perception of Recovery and Muscle Strength in Female Athletes
PubMed ID: 39954269
28‑day athlete trial showed improved sleep quality scores vs placebo.
- A New Ashwagandha Formulation (Zenroot™) Alleviates Stress and Anxiety Symptoms While Improving Mood and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Clinical Study
PubMed ID: 40875185
12‑week RCT of Zenroot™ (ashwagandha formulation) produced clinically meaningful PSQI improvements vs placebo.
- A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults
PubMed ID: 32540634
Large RCT (actigraphy) showed marked improvements in restorative sleep, sleep efficiency and total sleep time in non‑restorative sleepers.
Healthy aging (5)
- Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
PubMed ID: 38732539
Dose‑response reductions in stress hormones and inflammatory cytokines — mechanistically relevant to aging.
- Effect of ashwagandha (Withania somnifera) extract with Sominone (Somin-On™) to improve memory in adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study
PubMed ID: 40099725
Pilot RCT in mild cognitive impairment showed consistent improvements in memory and global cognition (aging‑relevant outcomes).
- Efficacy and safety of Ashwagandha (Withania somnifera) root extract on stress and weight management in adults: a prospective, randomized, double-blind, placebo-controlled study
PubMed ID: 41635453
24‑week RCT reduced BMI, perceived stress and serum cortisol — metabolic/stress improvements supportive of healthy aging.
- Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study
PubMed ID: 39498904
8‑week RCT improved episodic/working memory, attention and reduced mental fatigue—cognitive domains relevant to healthy aging.
- Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood
PubMed ID: 38931168
Acute and 30‑day cognitive improvements and reduced fatigue could support functional aging.
Focus & concentration (5)
- Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder
PubMed ID: 24330893
Adjunctive ashwagandha improved working memory and reaction‑time measures in bipolar patients.
- Effect of ashwagandha (Withania somnifera) extract with Sominone (Somin-On™) to improve memory in adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study
PubMed ID: 40099725
MCI pilot RCT improved multiple cognitive domains including memory/visuospatial processing (supporting focus).
- Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study
PubMed ID: 39498904
8‑week RCT showed improved attention accuracy and working memory on validated tests.
- Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood
PubMed ID: 38931168
Acute and 30‑day controlled study improved reaction time and attention measures objectively.
- Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions
PubMed ID: 28471731
Mild cognitive impairment RCT showed improvements in attention/processing speed and executive function.
Memory (5)
- Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder
PubMed ID: 24330893
Adjunctive ashwagandha in euthymic bipolar patients improved digit‑span backward (working memory) and some cognitive tasks.
- Effect of ashwagandha (Withania somnifera) extract with Sominone (Somin-On™) to improve memory in adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study
PubMed ID: 40099725
250 mg/day pilot RCT in MCI produced consistent improvements in multiple memory and cognitive measures.
- Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study
PubMed ID: 39498904
8‑week RCT showed significant improvements in episodic and working memory on validated tests.
- Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood
PubMed ID: 38931168
Acute and 30‑day study improved picture‑recognition reaction time and some memory measures.
- Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions
PubMed ID: 28471731
MCI RCT demonstrated significant improvements in immediate/delayed memory and multiple memory subtests versus placebo.
Immune support (4)
- Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
PubMed ID: 38732539
Dose‑response RCT reduced pro‑inflammatory cytokines (IL‑1β, IL‑6, TNF‑α) relevant to immune modulation.
- Comparative study of effect of Withania somnifera as an adjuvant to DOTS in patients of newly diagnosed sputum smear positive pulmonary tuberculosis
PubMed ID: 29933868
Adjunct to TB therapy increased CD4/CD8 counts and improved sputum conversion and HRQL, supporting immune benefit as adjunctive therapy.
- Withania somnifera as a safer option to hydroxychloroquine in the chemoprophylaxis of COVID-19: Results of interim analysis
PubMed ID: 34418550
Interim RCT in healthcare workers showed lower symptomatic COVID‑19 incidence vs HCQ (small/interim data).
- Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers
PubMed ID: 36419388
Phase III multi‑herb trial (includes ashwagandha) shortened COVID‑19 illness and lowered IL‑6 in subgroup (confounded formula).
Endurance (5)
- Effects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR Trial
PubMed ID: 30463324
Sensoril® RCT during resistance training improved upper/lower body strength and time‑trial performance, indicating improved stamina/endurance.
- Ashwagandha Root Extract Stabilises Physiological Stress Responses in Male and Female Team Sports Athletes During Pre-Season Training
PubMed ID: 41599843
Pre‑season trial improved male CMJ and stabilised stress biomarkers, indirectly supporting stamina/endurance.
- Effects of Ashwagandha ( Withania somnifera) standardized root extract on physical endurance and VO (2max) in healthy adults performing resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study
PubMed ID: 38988644
8‑week RCT reported improved VO2max and aerobic capacity in active adults (direct stamina measure).
- A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults
PubMed ID: 33600918
Athletic RCT reported significant VO2max gains and endurance‑related improvements versus placebo.
- Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial
PubMed ID: 26609282
Resistance‑training study showed greater strength and muscle size gains that can contribute to improved stamina.
Inflammation (4)
- A Novel Herbal Composition Alleviates Functional Constipation, Reduces Gastrointestinal Transit Time, and Improves Bowel Function in Adults: A Double-Blind, Randomized Clinical Study
PubMed ID: 38691810
60‑day RCT of two‑herb blend including ashwagandha decreased IL‑6 and other inflammatory markers (multi‑herb caveat).
- Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
PubMed ID: 38732539
Large dose‑response RCT showed significant reductions in IL‑1β, IL‑6 and TNF‑α versus placebo.
- A blend of Withania somnifera (L.) Dunal root and Abelmoschus esculentus (L.) Moench fruit extracts relieves constipation and improves bowel function: A proof-of-concept clinical investigation
PubMed ID: 37543151
Two‑herb formula produced decreases in IL‑6 and cortisol with increased IL‑10 (short trial, blended product).
- Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers
PubMed ID: 36419388
Polyherbal product including ashwagandha reduced IL‑6 in a COVID subgroup and shortened illness.
Strength (5)
- Effects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR Trial
PubMed ID: 30463324
Sensoril® 500 mg/day over 12 weeks produced large percent increases in back squat and bench press 1RM versus placebo.
- Ashwagandha Root Extract Stabilises Physiological Stress Responses in Male and Female Team Sports Athletes During Pre-Season Training
PubMed ID: 41599843
Male participants saw improved CMJ (explosive lower‑body power) after supplementation during training.
- Effects of Root Extract of Ashwagandha (Withania somnifera) on Perception of Recovery and Muscle Strength in Female Athletes
PubMed ID: 39954269
28‑day trial in female footballers produced greater grip‑strength gains than placebo.
- Effects of Ashwagandha ( Withania somnifera) standardized root extract on physical endurance and VO (2max) in healthy adults performing resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study
PubMed ID: 38988644
8‑week resistance‑training RCT showed substantial bench‑press 1RM and muscle girth gains vs placebo.
- Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial
PubMed ID: 26609282
Well‑controlled RCT in healthy men showed marked increases in 1RM strength (bench press, leg extension) with ashwagandha plus resistance training.
Sexual wellness (4)
- Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial
PubMed ID: 26609282
Resistance‑training trial reported increased testosterone in men, which is linked to libido.
- Comparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility: A triple-blind randomised clinical trial
PubMed ID: 29770466
Ashwagandha improved semen parameters (count, motility, morphology) which is consistent with effects on reproductive/sexual function.
- Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial
PubMed ID: 37740662
12‑week RCT raised free testosterone in men (+12.9% vs −1.7% placebo), a plausible mechanism for increased libido.
- Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study
PubMed ID: 26504795
8‑week RCT in women found improvements in FSFI domains and reduced sexual distress with ashwagandha plus counseling.
Fertility (3)
- Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study
PubMed ID: 34553463
Perimenopausal trial improved estradiol and gonadotropin profiles alongside symptom improvement, indicating reproductive hormone support.
- Comparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility: A triple-blind randomised clinical trial
PubMed ID: 29770466
90‑day RCT reported significant improvements in sperm count, progressive motility and morphology versus baseline.
- Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial
PubMed ID: 37740662
Significant increase in free testosterone in men suggests support for male reproductive health parameters.
Antioxidant (3)
- A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults
PubMed ID: 33600918
Athletic RCT reported significant increases in antioxidant markers versus placebo.
- A Novel Herbal Composition Alleviates Functional Constipation, Reduces Gastrointestinal Transit Time, and Improves Bowel Function in Adults: A Double-Blind, Randomized Clinical Study
PubMed ID: 38691810
Two‑herb product including ashwagandha decreased IL‑6 and cortisol and altered other biomarkers tied to oxidative stress.
- Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
PubMed ID: 38732539
Dose‑response RCT reduced inflammatory cytokines (IL‑1β, IL‑6, TNF‑α), consistent with lowered oxidative/inflammatory stress.
Weight management (3)
- Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study
PubMed ID: 24014929
Short schizophrenia pilot found reductions in fasting glucose and triglycerides after ashwagandha, which are relevant to metabolic/weight management.
- Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial
PubMed ID: 26609282
Resistance training trial showed greater reduction in body fat percentage with ashwagandha versus placebo.
- Efficacy and safety of Ashwagandha (Withania somnifera) root extract on stress and weight management in adults: a prospective, randomized, double-blind, placebo-controlled study
PubMed ID: 41635453
24‑week double‑blind RCT showed large, clinically significant BMI and weight reductions vs placebo.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Ashwagandha
Search all3061 products whose verified label declares Ashwagandha — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.