Fiber
13 benefits mapped to clinical evidence across supplements.
Dose per serving from products
39 products in our catalogue print how much Fiber a serving holds.
Most common: 1 g to 2.5 g and 5 g to 10 g, 23% of 39 products each.
| Dose per serving | Products |
|---|---|
| 100 mg or less | 2 |
| 100 mg to 250 mg | 4 |
| 250 mg to 500 mg | 0 |
| 500 mg to 1 g | 6 |
| 1 g to 2.5 g | 9 |
| 2.5 g to 5 g | 4 |
| 5 g to 10 g | 9 |
| 10 g to 25 g | 2 |
| 25 g to 50 g | 1 |
| over 50 g | 2 |
Dose per serving from research
681 study groups in 406 studies say how much Fiber participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 10 g to 25 g, 38% of 681 study groups.
| Daily dose | Study groups |
|---|---|
| 1 g or less | 9 |
| 1 g to 2.5 g | 45 |
| 2.5 g to 5 g | 85 |
| 5 g to 10 g | 134 |
| 10 g to 25 g | 259 |
| 25 g to 50 g | 113 |
| 50 g to 100 g | 30 |
| over 100 g | 6 |
Commonly used together
93 of 656 study groups took Fiber with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Beta-Glucans | 14 |
| Inulin | 11 |
| Probiotics | 10 |
| Calcium | 8 |
| Phytosterols | 6 |
| Whey Protein | 4 |
| protein | 4 |
| Anthocyanins | 3 |
Benefit Evidence
Research sources
Wellbeing (310)
- Effect of Gum Arabic (Acacia Senegal) supplementation on visceral adiposity index (VAI) and blood pressure in patients with type 2 diabetes mellitus as indicators of cardiovascular disease (CVD): a randomized and placebo-controlled clinical trial
PubMed ID: 29558953
Multiple cardiometabolic improvements (HDL up, BP down, reduced visceral adiposity) with gum arabic support longer‑term health.
- A dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnormalities by modifying faecal microbiota in people with type 2 diabetes
PubMed ID: 30266575
Sustained improvements in HbA1c, LDL and CRP from a high‑fiber/polyphenol diet suggest long‑term cardiometabolic benefits.
- A new dietary strategy for long-term treatment of the metabolic syndrome is compared with the American Heart Association (AHA) guidelines: the MEtabolic Syndrome REduction in NAvarra (RESMENA) project
PubMed ID: 23968597
Dietary pattern with higher fiber led to modest anthropometric and metabolic gains that support long‑term health.
- Gut Permeability Might be Improved by Dietary Fiber in Individuals with Nonalcoholic Fatty Liver Disease (NAFLD) Undergoing Weight Reduction
PubMed ID: 30453660
Improvements in gut permeability and liver health from increased fiber intake imply better long‑term digestive/metabolic outcomes.
- Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
PubMed ID: 35300378
Konjac produced durable improvements in weight, glycemia, lipids and microbiota over 5 weeks—strong contributor to long‑term wellness if maintained.
- Diet and sex hormone-binding globulin
PubMed ID: 10634401
Large study linking higher fiber intake with higher SHBG—suggests long-term metabolic implications.
- Intake of vegetables rich in carotenoids and risk of coronary heart disease in men: The Physicians' Health Study
PubMed ID: 11171873
Large prospective study: higher vegetable intake associated with ~23% lower CHD risk over 12 years (observational, consistent with long-term wellness benefits).
- Is intake of breakfast cereals related to total and cause-specific mortality in men?
PubMed ID: 12600848
Large cohort: higher whole-grain (fiber-rich) breakfast intake associated with ~17% lower total mortality and ~20% lower CVD mortality—strong observational support for long-term benefit.
- Associations between dietary patterns and arterial stiffness, carotid artery intima-media thickness and atherosclerosis
PubMed ID: 20431391
Cohort data linking low‑fiber patterns to increased arterial stiffness suggests long‑term vascular risk associated with low fiber intake.
- Effects of a healthy Nordic diet on cardiovascular risk factors in hypercholesterolaemic subjects: a randomized controlled trial (NORDIET)
PubMed ID: 20964740
Randomized trial of a diet high in plant/fiber foods improved multiple cardiometabolic risk factors (LDL, insulin, BP), supporting long‑term health benefits (multi‑component intervention).
- The influence of a physician and patient intervention program on dietary intake
PubMed ID: 23999279
Large randomized interventions improved diet quality and increased fiber intake with modest cardiometabolic gains—relevant to long-term wellness.
- Dietary total and insoluble fiber intakes are inversely associated with prostate cancer risk
PubMed ID: 24553693
Prospective cohort showed higher total/insoluble/legume fibre associated with substantially lower prostate cancer risk (observational but long‑term wellness relevant).
- Brown and golden flaxseed reduce intestinal permeability and endotoxemia, and improve the lipid profile in perimenopausal overweight women
PubMed ID: 35311432
Flaxseed improved gut barrier and LDL in overweight women — changes that could translate into longer‑term health benefits.
- Metabolomics-Based Biomarker for Dietary Fat and Associations with Chronic Disease Risk in Postmenopausal Women
PubMed ID: 37245660
Prospective data indicating that fiber attenuates diet–disease associations (CHD, diabetes) supports a role for fiber in long-term disease risk reduction.
- Association of dietary fibre with type 2 diabetes risk is modified by transcription factor 7 like 2 genotype in men with impaired fasting glucose: The T2D-GENE study
PubMed ID: 40961511
Large study showing much lower incidence of type 2 diabetes with higher fiber intake provides strong evidence that dietary fiber supports long-term metabolic health and disease prevention.
- Effect of type of fiber, site of fermentation, and method of analysis on digestibility of soluble and insoluble fiber in rabbits
PubMed ID: 26115273
Sustained changes in where fiber is digested and mucin production could have long-term implications for gut health and systemic wellbeing (mechanistic evidence).
- The Impact of Glucomannan, Inulin, and Psyllium Supplementation (Soloways(TM)) on Weight Loss in Adults with FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 38398881
Sustained weight, fat-mass and appetite improvements over 6 months with combined fibers support long-term wellness objectives.
- Potent antihypertensive action of dietary flaxseed in hypertensive patients
PubMed ID: 24126178
Milled flaxseed produced substantial long-term BP reductions in PAD patients — meaningful long-term cardiovascular wellness support.
- Diabetes Therapeutics of Prebiotic Soluble Dietary Fibre and Antioxidant Anthocyanin Supplement in Patients with Type 2 Diabetes: Randomised Placebo-Controlled Clinical Trial
PubMed ID: 40218856
Inulin + rice bran (fiber) + anthocyanins produced durable improvements in glycemia and LDL over 60 days in T2DM—translatable to long‑term risk reduction potential.
- Hypocholesterolaemic effects of lupin protein and pea protein/fibre combinations in moderately hypercholesterolaemic individuals
PubMed ID: 22032303
Large trial showing soluble fiber as part of bars reduced cholesterol—implications for long‑term cardiovascular risk reduction.
- Effect of arabinogalactan on the gut microbiome: A randomized, double-blind, placebo-controlled, crossover trial in healthy adults
PubMed ID: 34004416
Sustained microbiome modulation with arabinogalactan supports longer‑term gut health, which contributes to overall wellness.
- Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial
PubMed ID: 15383514
Long (2‑year) Mediterranean‑style dietary intervention with higher fiber improved inflammation, endothelial function and insulin sensitivity—supports long‑term health though fiber not isolated.
- Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity
PubMed ID: 39033197
Sustained microbiota improvements from six months of inulin could plausibly support long‑term wellness, though clinical long‑term outcomes were not reported.
- Changes in Quantity and Sources of Dietary Fiber from Adopting Healthy Low-Fat vs. Healthy Low-Carb Weight Loss Diets: Secondary Analysis of DIETFITS Weight Loss Diet Study
PubMed ID: 34684626
12‑month trial documented differing fiber intakes/sources across diets—relevance for sustained dietary patterns that support long‑term health.
- The effects of concentrated barley beta-glucan on blood lipids in a population of hypercholesterolaemic men and women
PubMed ID: 17445284
Robust LDL-C reductions from β-glucan support long-term cardiovascular risk reduction potential.
- Combining functional features of whole-grain barley and legumes for dietary reduction of cardiometabolic risk: a randomised cross-over intervention in mature women
PubMed ID: 24063257
Barley+legume diet lowered LDL and estimated Framingham risk, indicating broader long-term wellness implications.
- Effects of high β-glucan barley on visceral fat obesity in Japanese individuals: A randomized, double-blind study
PubMed ID: 28870472
Longer replacement of staple with high β‑glucan barley reduced visceral fat/body weight—supports longer‑term metabolic health.
- Alterations in gut microbiota composition and metabolic parameters after dietary intervention with barley beta glucans in patients with high risk for metabolic syndrome development
PubMed ID: 30396006
Metabolic and microbiota shifts over 4 weeks suggest potential contributions to long‑term wellness.
- Barley-Based Cereals Enhance Metabolic Health and Satiety in Overweight Korean Adults: A Randomized Trial
PubMed ID: 40944189
6‑week trial showed sustained improvements in body composition and insulin resistance—indicative of longer‑term wellness benefits if maintained.
- Anti-Inflammatory Diet Prevents Subclinical Colonic Inflammation and Alters Metabolomic Profile of Ulcerative Colitis Patients in Clinical Remission
PubMed ID: 36014800
Reduced colonic inflammation with higher fiber intake suggests benefits for long‑term gut health in susceptible patients.
- Nutritional and health benefits of a partial substitution of red and processed meat with non-soy legumes: a 6-week randomized controlled trial in healthy working-age men
PubMed ID: 40828321
Legume substitution increased fiber and improved LDL/total cholesterol, implying longer‑term cardiovascular risk benefits.
- Intake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study
PubMed ID: 8941095
Large prospective cohort showing higher fiber linked to lower coronary death — supports long‑term health benefits.
- Telephone counseling intervention increases intakes of micronutrient- and phytochemical-rich vegetables, fruit and fiber in breast cancer survivors
PubMed ID: 14747688
Sustained increases in fiber and produce intake in survivors with biomarker improvements — strong support for long‑term wellness via diet change.
- Effects of a low-fat vegan diet and a Step II diet on macro- and micronutrient intakes in overweight postmenopausal women
PubMed ID: 15325679
Randomized dietary shift to higher fiber in overweight postmenopausal women supports longer‑term wellness outcomes (indirect).
- Changes in nutrient intake and dietary quality among participants with type 2 diabetes following a low-fat vegan diet or a conventional diabetes diet for 22 weeks
PubMed ID: 18926128
In T2D patients, low‑fat vegan diet raised fiber and improved overall diet quality — relevant to long‑term disease management/wellness.
- Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds
PubMed ID: 25326876
Portfolio diet (including viscous fiber) significantly lowered LDL‑C—supports long‑term cardiometabolic wellness.
- Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial
PubMed ID: 17386092
Combined lipid lowering and fermentability suggest both immediate and mechanistic long‑term health benefits.
- Simultaneous intake of beta-glucan and plant stanol esters affects lipid metabolism in slightly hypercholesterolemic subjects
PubMed ID: 17311944
Mechanistic cholesterol lowering data (reduced absorption, ↑bile acid synthesis) supports durable wellness effects when consumed regularly.
- Physicochemical properties of oat β-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial
PubMed ID: 20660224
Large trial showing modest sustained LDL reductions with appropriate β‑glucan supports long‑term cardiometabolic wellness.
- Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians
PubMed ID: 22118569
Pooled evidence of modest LDL lowering across populations supports population‑level long‑term wellness benefit.
- Metabolite Biomarkers Linking a High-Fiber Rye Intervention with Cardiometabolic Risk Factors: The RyeWeight Study
PubMed ID: 40838659
Large trial: high‑fiber rye linked to favorable weight/fat loss and lower CRP, consistent with long‑term wellness benefits.
- Preventive effects of diets supplemented with sweetie fruits in hypercholesterolemic patients suffering from coronary artery disease
PubMed ID: 15193907
Short‑term lipid improvements in post‑CABG patients suggest potential contribution to long‑term heart health (limited duration trial).
- The formation of short-chain fatty acids is positively associated with the blood lipid-lowering effect of lupin kernel fiber in moderately hypercholesterolemic adults
PubMed ID: 24572041
Cholesterol reductions and increased SCFA with lupin fiber imply cardiovascular and colonic benefits relevant to long-term wellness.
- Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals
PubMed ID: 23977723
Four-week butyrylated resistant starch produced pronounced shifts in butyrate and microbiota that could support longer-term gut health if sustained.
- Effects of supplementation with nondigestible carbohydrates on fecal calprotectin and on epigenetic regulation of SFRP1 expression in the large-bowel mucosa of healthy individuals
PubMed ID: 28077379
Resistant starch/polydextrose induced large decreases in colonic SFRP1 expression (molecular marker) indicating potential long‑term mucosal effects.
- Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake
PubMed ID: 32075887
Mediterranean dietary shift (more fibre) improved cholesterol and induced beneficial microbiome/metabolome changes—supports long-term health.
- A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial
PubMed ID: 33388204
Plant-forward diet reduced zonulin and improved microbiota; changes are supportive of long-term intestinal and cardiometabolic wellness.
- Effects of high-fiber diets enriched with carbohydrate, protein, or unsaturated fat on circulating short chain fatty acids: results from the OmniHeart randomized trial
PubMed ID: 31927581
Sustained high-fiber diets produced systemic SCFA changes linked to improved metabolic markers relevant to long-term health.
- Short-chain fatty acids are key mediators of the favorable effects of the Mediterranean diet on intestinal barrier integrity: data from the randomized controlled LIBRE trial
PubMed ID: 36055959
RCT showed SCFA increases and improved barrier markers over 3 months—mechanisms supporting long-term wellness.
- The prebiotic effects of soluble dietary fiber mixture on renal anemia and the gut microbiota in end-stage renal disease patients on maintenance hemodialysis: a prospective, randomized, placebo-controlled study
PubMed ID: 36517799
Soluble-fiber supplementation produced systemic butyrate increases and hematologic improvements suggesting durable health benefits.
- A microbiome-targeting fibre-enriched nutritional formula is well tolerated and improves quality of life and haemoglobin A1c in type 2 diabetes: A double-blind, randomized, placebo-controlled trial
PubMed ID: 36594522
Durable HbA1c reductions and microbiome shifts in T2D support long‑term metabolic wellness.
- Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity
PubMed ID: 40669445
Chicory root increased butyrate activity and improved insulin sensitivity and triglycerides—supports longer‑term metabolic health.
- The anti-inflammatory effects of three different dietary supplement interventions
PubMed ID: 41094562
Synbiotic reduced multiple inflammatory proteins and increased butyrate—broad anti‑inflammatory and wellness implications.
- Supplementation with short-chain fatty acids and a prebiotic improves clinical outcome in Parkinson's disease: a randomized double-blind prospective study
PubMed ID: 41350593
Six‑month SCFA/prebiotic supplementation produced clinically meaningful improvements in Parkinson’s patients—evidence of longer‑term impact of microbiome/SCFA targeting.
- [Influence of physical therapy on intestinal microbiota, blood pressure control and systemic inflammation level: a randomized controlled study of 84 patients with arterial hypertension]
PubMed ID: 40421856
Fiber‑enriched diet produced multimodal improvements (SCFAs, endotoxin, BP, arterial stiffness) over 12 months—supports long‑term wellness.
- An Indian experiment with nutritional modulation in acute myocardial infarction
PubMed ID: 1550016
Post‑MI diet that increased soluble fibre was associated with improved lipids and weight—outcomes relevant to long‑term cardiovascular wellness.
- Reduced serum cholesterol with dietary change using fat-modified and oat bran supplemented diets
PubMed ID: 2154513
Oat bran lowered total cholesterol meaningfully; lipid improvements support long‑term cardiovascular wellness.
- Colorectal adenomas and diet: a case-control study of subjects participating in the Nottingham faecal occult blood screening programme
PubMed ID: 8381298
Observational association of high cereal fiber with much lower colorectal adenoma prevalence — supportive of long‑term digestive health benefits.
- Randomized, double-blinded, placebo-controlled study of effect of wheat bran fiber and calcium on fecal bile acids in patients with resected adenomatous colon polyps
PubMed ID: 8537982
Sustained reduction in fecal bile acids with wheat bran over 9 months — plausible mechanism for long‑term colon health.
- Nutrient intake and blood pressure in the Dietary Intervention Study in Children
PubMed ID: 9095079
Higher fiber associated with lower blood pressure in children — supports long‑term cardiometabolic benefits.
- Non-digestible oligosaccharides and calcium absorption in girls with adequate calcium intakes
PubMed ID: 12088517
Prebiotic (inulin+oligofructose) increased calcium absorption in girls—plausibly supports bone health and long‑term wellness via fermentation-mediated effects.
- The PREMIER intervention helps participants follow the Dietary Approaches to Stop Hypertension dietary pattern and the current Dietary Reference Intakes recommendations
PubMed ID: 17761231
DASH‑style interventions improved diet quality and nutrient intakes (including fiber), supporting long‑term cardiometabolic wellness.
- Longitudinal effect of 20-year infancy-onset dietary intervention on food consumption and nutrient intake: the randomized controlled STRIP study
PubMed ID: 30397257
Two-decade dietary counseling starting in infancy produced sustained small increases in fiber and healthier diets, supporting long-term wellness.
- Randomized Controlled Trial of Storytelling vs Didactic Education Effects on Dietary Colorectal Cancer Risk Behaviors among Latinxs
PubMed ID: 34421047
Education intervention yielded modest fiber increases over 12 weeks, supporting scalable public-health improvements to long-term diet and wellness.
- Nutritional quality of calorie restricted diets in the CALERIE™ 1 trial
PubMed ID: 35643360
Calorie-restriction trial produced durable improvements in fiber intake and diet quality consistent with long-term wellness benefits.
- Beneficial Effects of a Freeze-Dried Kale Bar on Type 2 Diabetes Patients: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
PubMed ID: 39519473
Kale bars improved glycemic control and modest weight loss over 12 weeks in T2D, indicating potential long‑term metabolic wellness benefits from fiber‑rich whole foods.
- Anti-Inflammatory Diet and Probiotic Supplementation as Strategies to Modulate Immune Dysregulation in Autism Spectrum Disorder
PubMed ID: 40871692
Anti-inflammatory and fiber-rich dietary intervention produced immunomodulatory changes in children with ASD; may support broader long-term health via lowered inflammation (small study).
- Co-administration of viscous fiber, Salba-chia and ginseng on glycemic management in type 2 diabetes: a double-blind randomized controlled trial
PubMed ID: 33486572
Modest HbA1c reduction over 24 weeks in T2D from a viscous-fiber-containing intervention suggests reduced long-term metabolic risk.
- Effect of chicory inulin-type fructan-containing snack bars on the human gut microbiota in low dietary fiber consumers in a randomized crossover trial
PubMed ID: 32320024
Durable bifidogenic microbiome changes with inulin-type fructans support a microbiome-mediated contribution to long-term wellness.
- Single-blind, placebo controlled randomised clinical study of chitosan for body weight reduction
PubMed ID: 26747458
Sustained 90-day weight, body-fat and visceral-fat reductions with chitosan indicate potential long-term wellness benefits if maintained.
- The diet and moderate exercise trial (DAMET): results after 24 weeks
PubMed ID: 1290315
Dietary pattern with increased fruits/vegetables (higher fiber) improved cardiometabolic risk factors—supports long‑term wellness though exercise confounds results.
- Plasma F(2)-isoprostanes Are Positively Associated with Glycemic Load, but Inversely Associated with Dietary Polyunsaturated Fatty Acids and Insoluble Fiber in Postmenopausal Women
PubMed ID: 28747487
Large observational study: higher insoluble fiber associated with lower oxidative stress—consistent with benefits for long‑term health.
- Improvements in Glycemic, Micronutrient, and Mineral Indices in Arab Adults with Pre-Diabetes Post-Lifestyle Modification Program
PubMed ID: 31731609
Six‑month lifestyle program raising fiber intake improved glycemic markers in prediabetes, supporting reduced long-term disease risk (combined intervention).
- Quality of Life: Psychological Symptoms-Effects of a 2-Month Healthy Diet and Nutraceutical Intervention; A Randomized, Open-Label Intervention Trial (RISTOMED)
PubMed ID: 32197408
Multimodal healthy-diet intervention including higher fiber reduced depressive symptoms and some inflammation markers—consistent with long-term wellness benefits (confounded intervention).
- Effects of a high-fiber, low-fat diet intervention on serum concentrations of reproductive steroid hormones in women with a history of breast cancer
PubMed ID: 15197199
Large dietary intervention that increased fiber intake produced a meaningful reduction in bioavailable estradiol (a long-term health biomarker in breast cancer survivors).
- Assessment of DNA damage and its modulation by dietary and genetic factors in smokers using the Comet assay: a biomarker model
PubMed ID: 16076733
Prebiotic (fiber) interventions reduced genotoxic markers in faecal water, an effect consistent with long-term protective potential.
- Diet Quality and Protein-Bound Uraemic Toxins: Investigation of Novel Risk Factors and the Role of Microbiome in Chronic Kidney Disease
PubMed ID: 34776340
Higher fiber intake in CKD associated with lower uraemic toxins and favorable microbiome correlations.
- Improved Plasma Lipids, Anti-Inflammatory Activity, and Microbiome Shifts in Overweight Participants: Two Clinical Studies on Oral Supplementation with Algal Sulfated Polysaccharide
PubMed ID: 36005503
Anti-inflammatory effects and microbiome changes in overweight adults may support long-term health.
- New approaches in the nutritional treatment of advanced chronic kidney disease
PubMed ID: 36402686
Dietary intervention increasing vegetables/fiber slowed kidney function decline without causing hyperkalemia.
- Fiber-multivitamin combination therapy: a beneficial influence on low-density lipoprotein and homocysteine
PubMed ID: 12200762
Soluble-fiber intervention reduced LDL/ApoB which supports long-term cardiometabolic wellness.
- Association of dietary patterns derived by reduced-rank regression with colorectal cancer risk and mortality
PubMed ID: 39607503
Prospective cohort showed a borderline association of a high-fiber dietary pattern with lower colorectal/colon cancer risk—relevant to long-term health.
- Association between whole-grain consumption, tryptophan metabolism and psychological distress: a secondary analysis of a randomised controlled trial
PubMed ID: 38826077
Whole‑grain (fiber‑rich) intake linked to higher IPA (a potentially beneficial microbial metabolite) in a weight‑management trial — supports long‑term health pathways.
- The effect of foods containing refined Konjac meal on human lipid metabolism
PubMed ID: 2158794
Konjac's large lipid improvements in hyperlipidemic elderly suggest long-term cardiometabolic benefits if sustained.
- Dietary strategies for risk-factor modification to prevent cardiovascular diseases
PubMed ID: 1666320
One‑year heart‑healthy dietary intervention including more fiber reduced risk factors and cardiovascular events — supports long‑term health (multifactorial).
- Influence of two guar preparations on glycosylated hemoglobin, total cholesterol and triglycerides in patients with diabetes mellitus
PubMed ID: 1335441
Guar fibre improved glycemic control and cholesterol in diabetics, outcomes relevant to long‑term health.
- Wheat-bran and oat-bran supplements' effects on blood lipids and lipoproteins
PubMed ID: 1315121
Oat bran reduced total and LDL cholesterol in controlled feeding study—supports long‑term cardiometabolic wellness.
- A dietary fibre supplement in the treatment of mild hypertension. A randomized, double-blind, placebo-controlled trial
PubMed ID: 1313484
Fibre supplement reduced BP, insulin and weight—factors that support long‑term wellness.
- Dietary modulators of lipid metabolism in the Indian diet-heart study (I.D.H.S.)
PubMed ID: 1316885
Short-term randomized dietary change including increased fiber lowered atherogenic lipids — supports longer-term cardiovascular risk reduction.
- Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of one year follow up
PubMed ID: 1586782
Post-MI diet including soluble fiber produced fewer cardiac events and lower mortality at one year — strong long-term wellness signal (multifactorial).
- Dietary fiber and coronary heart disease in middle-aged hypercholesterolemic men
PubMed ID: 8398218
Prospective data linking higher fiber intake with modestly lower CHD risk supports long-term wellness benefits.
- Effective control of hypercholesterolemia in children with dietary interventions based in pediatric practice
PubMed ID: 8483855
Pediatric nutrition programs that increased fiber also lowered cholesterol—practical long-term prevention evidence.
- Effects of diet and lifestyle changes on atherosclerotic risk factors after 24 weeks on the Indian Diet Heart Study
PubMed ID: 8498367
Large lifestyle intervention including soluble fiber produced lipid improvements over 24 weeks—supports longer-term cardiometabolic wellness (multifactorial).
- Diet, lipids and cardiovascular disease in women
PubMed ID: 8409106
AHA/high-fiber dietary patterns produced consistent LDL/total cholesterol reductions across trials—supports long-term cardiovascular wellness.
- Psyllium reduces blood lipids in men and women with hyperlipidemia
PubMed ID: 8160720
Psyllium's LDL/total cholesterol reductions support long-term cardiovascular health when used consistently.
- The cholesterol-lowering effect of a breakfast cereal containing psyllium fibre
PubMed ID: 7830631
Daily psyllium cereal produced modest LDL/total cholesterol declines — contributes to long-term risk lowering.
- Long-term treatment of hypercholesterolemia with dietary fiber
PubMed ID: 7985708
Sustained modest reductions in total and LDL cholesterol over ~1 year with mixed fiber intake — relevant to long-term cardiovascular risk reduction.
- Long-term comparison of three dietary prescriptions in the treatment of NIDDM
PubMed ID: 8112194
Long (18-month) diet study including high-fibre options produced sustained improvements in glycemic control and LDL—relevant to long-term wellness.
- Wheat fibre, lactulose and rectal mucosal proliferation in individuals with a family history of colorectal cancer
PubMed ID: 7827943
Wheat fiber reduced rectal mucosal proliferation (~29% reduction), a biomarker linked to colorectal cancer risk — supports long‑term colorectal health.
- Soluble fiber enhances the hypocholesterolemic effect of the step I diet in childhood
PubMed ID: 8586774
Psyllium lowered total and LDL cholesterol in children — direct evidence that fiber can support long-term cardiovascular wellness.
- [Evaluation of the action of glucomannan on metabolic parameters and on the sensation of satiation in overweight and obese patients]
PubMed ID: 7796558
Glucomannan improved weight and glycaemic/cholesterol outcomes when added to diet—supportive of long-term health goals.
- Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men
PubMed ID: 7872224
Konjac’s robust lipid improvements (total/LDL/TG) are consistent with longer-term cardiometabolic wellness benefits.
- von Willebrand factor, a possible indicator of endothelial cell damage, decreases during long-term compliance with a lipid-lowering diet
PubMed ID: 7782727
Three‑year dietary intervention including higher fiber reduced lipids and vWF—consistent with potential long‑term health benefits though fiber was one of multiple changes.
- Effect of psyllium in hypercholesterolemia at two monounsaturated fatty acid intakes
PubMed ID: 9129487
Psyllium's LDL reductions are relevant to long-term cardiovascular wellness.
- Effects of lowering fat and increasing dietary fiber on fasting and postprandial plasma lipids in hypercholesterolemic subjects consuming a mixed Mediterranean-Western diet
PubMed ID: 9394698
Sustained reductions in total and LDL cholesterol with higher dietary fiber support long‑term cardiovascular risk reduction, a component of long‑term wellness.
- Mediterranean dietary pattern in a randomized trial: prolonged survival and possible reduced cancer rate
PubMed ID: 9625397
Large trial: Mediterranean‑style (higher fiber) diet associated with substantially fewer deaths and cancers over 4 years—strong evidence for long‑term benefit of a fiber‑rich diet, though multi‑component.
- Cookies enriched with psyllium or oat bran lower plasma LDL cholesterol in normal and hypercholesterolemic men from Northern Mexico
PubMed ID: 9853540
Large LDL reductions from psyllium/oat bran indicate cardiovascular risk reduction potential — supports long‑term health.
- Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia
PubMed ID: 10500014
Psyllium's improvements in lipids and postprandial glucose suggest benefits relevant to long-term cardiometabolic health.
- Cholesterol lowering with high-viscosity hydroxypropylmethylcellulose
PubMed ID: 10569330
Sustained LDL reductions with HPMC indicate a plausible contribution to long-term cardiovascular risk reduction.
- Dietary fiber and plant foods in relation to colorectal cancer mortality: the Seven Countries Study
PubMed ID: 10188715
Large cohort: an increase of ~10 g/day fiber associated with substantially lower 25‑year colorectal cancer mortality—strong observational evidence linking higher fiber intake to long-term health outcomes.
- Long-term blood cholesterol-lowering effects of a dietary fiber supplement
PubMed ID: 10429748
Randomized multi-fiber supplement produced sustained LDL reductions over 15–51 weeks—meaningful long-term risk-factor improvements supportive of long-term wellness.
- Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance
PubMed ID: 10447232
Intensive lifestyle program with high‑fiber diet produced sustained 1‑yr weight loss and improved fibrinolysis—supports long‑term wellness.
- The Finnish Diabetes Prevention Study
PubMed ID: 10889804
Longer‑term lifestyle program (high fiber + exercise) reduced weight and improved glucose and CVD risk markers, supporting long‑term wellness.
- High-molecular-weight hydroxypropylmethylcellulose taken with or between meals is hypocholesterolemic in adult men
PubMed ID: 10867040
Short‑term LDL/total cholesterol reductions with viscous fiber support cardiovascular risk reduction that contributes to long‑term wellness.
- Long-term effect of fibre supplement and reduced energy intake on body weight and blood lipids in overweight subjects
PubMed ID: 11294130
Fibre supplement trial over 24 weeks showed sustainable supplement use producing extra weight loss — relevant to long-term wellness strategies when combined with caloric control.
- Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
PubMed ID: 11333990
Lifestyle program including increased fiber halved diabetes incidence over 4 years — strong evidence for long-term wellness benefits of multicomponent lifestyle change (fiber one contributor).
- Implementation of a 4-y, high-fiber, high-fruit-and-vegetable, low-fat dietary intervention: results of dietary changes in the Polyp Prevention Trial
PubMed ID: 11522565
Large 4-year trial achieved sustained dietary change (higher fibre) with biomarker improvements and modest weight effects — strong population-level support for long-term wellness via dietary fiber.
- A computerized social cognitive intervention for nutrition behavior: direct and mediated effects on fat, fiber, fruits, and vegetables, self-efficacy, and outcome expectations among food shoppers
PubMed ID: 11394559
Behavioral supermarket program increased fiber intake — supports sustained dietary changes beneficial for long-term wellness.
- Sex and hormonal status influence plasma lipid responses to psyllium
PubMed ID: 11566640
Psyllium's modest lipid improvements contribute to long-term cardiovascular risk reduction potential.
- Self-regulation training enhances dietary self-efficacy and dietary fiber consumption
PubMed ID: 11573751
Goal-setting interventions produced large increases in fiber consumption (behavioral support for long-term wellness).
- Dietary patterns and nutrient intakes of 7-year-old children taking part in an atherosclerosis prevention project in Finland
PubMed ID: 11985408
Long-term dietary counseling increased fibre-rich food intake from infancy, associated with healthier nutrient intakes and lower cholesterol—supports population-level long-term wellness.
- Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control?
PubMed ID: 11978259
Whole-grain oat cereal reduced cholesterol and glucose and lowered medication needs—strong evidence that oat fibre supports cardiometabolic aspects of long-term wellness.
- [Influence of probiotics and fibre on the incidence of bacterial infections following major abdominal surgery - results of a prospective trial]
PubMed ID: 12436353
Enteral nutrition with fibre plus probiotics greatly reduced postoperative infections and antibiotic use—clinical evidence that fibre-including regimens can improve important health outcomes in hospitalized patients.
- The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity
PubMed ID: 14633807
Large RCT lifestyle program with increased fiber produced sustained weight loss and cardiometabolic improvements—strong relevance to long-term wellness.
- Effects of dietary intervention on IGF-I and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial
PubMed ID: 12947426
Medium-term dietary intervention increased fiber and improved multiple metabolic/hormonal markers—relevant to wellness.
- Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial
PubMed ID: 12684358
Two-year lifestyle program (incl. more fiber) reduced inflammation and improved health markers relevant to long-term wellness.
- Prevention of diabetes mellitus in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study: results from a randomized clinical trial
PubMed ID: 12819313
Intensive lifestyle program including increased fiber reduced progression to diabetes over ~3 years — long‑term disease risk reduction (multifactorial).
- Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme
PubMed ID: 12737857
Large PLCO analysis: higher dietary fiber (especially cereal/fruit fiber) associated with substantially lower distal colorectal adenoma risk.
- Short-term effects of an intensive lifestyle modification program on lipid peroxidation and antioxidant systems in patients with coronary artery disease
PubMed ID: 14724371
An intensive lifestyle program that included a high-fiber diet improved antioxidant markers in coronary artery disease patients, consistent with contributions of fiber-containing diets to long-term health (multi-component intervention).
- Effect of soluble fiber intake in lipid and glucose levels in healthy subjects: a randomized clinical trial
PubMed ID: 15163472
Soluble fiber lowered LDL and fasting glucose (risk-factor improvements supportive of long-term health).
- Supplementation of wheat fibre can improve risk profile in patients with dysmetabolic cardiovascular syndrome
PubMed ID: 15187818
Wheat fiber improved multiple cardiometabolic risk markers while consumed, suggesting support for long-term risk reduction if maintained.
- Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial
PubMed ID: 14744846
High-fibre ad libitum diet produced sustained body-fat and weight improvements during the trial—implications for long-term wellness.
- Dietary fiber intake and risk factors for cardiovascular disease in French adults
PubMed ID: 16332650
Epidemiologic associations link higher fiber intake with lower cardiometabolic risk markers, supporting a role in long-term health (observational).
- Effects of agar (kanten) diet on obese patients with impaired glucose tolerance and type 2 diabetes
PubMed ID: 15642074
Agar reduced weight/BMI and lowered total cholesterol modestly in at-risk patients, supporting longer-term cardiometabolic wellness potential.
- Experiences with three different fiber supplements in weight reduction
PubMed ID: 15614200
Viscous-fiber supplements aided weight loss (a long-term wellness factor) in short-term trials; long-term effects not established here.
- Effect of combining psyllium fiber with simvastatin in lowering cholesterol
PubMed ID: 15911730
Psyllium added to statin produced additional lipid lowering, relevant to long-term cardiovascular health.
- Lupin kernel fibre-enriched foods beneficially modify serum lipids in men
PubMed ID: 15508014
Sustained LDL reductions from lupin fibre support long-term cardiovascular risk reduction potential.
- Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial
PubMed ID: 16585662
Lifestyle interventions including high-fiber DASH diets led to sustained healthier diets and modest reductions in hypertension risk.
- High-fibre, low-fat diet predicts long-term weight loss and decreased type 2 diabetes risk: the Finnish Diabetes Prevention Study
PubMed ID: 16541277
Lower-fat, higher-fiber diets predicted better long-term weight loss and reduced diabetes risk in people with impaired glucose tolerance.
- Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study
PubMed ID: 17098085
Large diabetes prevention trial showed increased fiber (within lifestyle program) was associated with ~36–43% relative reduction in incident diabetes over follow-up.
- Low-fat dietary pattern and weight change over 7 years: the Women's Health Initiative Dietary Modification Trial
PubMed ID: 16391215
Large long-term dietary trial with higher fiber intake showed small sustained weight benefits, implying modest long-term health support.
- A combination therapy including psyllium and plant sterols lowers LDL cholesterol by modifying lipoprotein metabolism in hypercholesterolemic individuals
PubMed ID: 16988115
LDL reductions with psyllium-containing product support long-term cardiovascular risk reduction, though sterol confounder exists.
- Health Hunters--an intervention to prevent overweight and obesity in young high-risk women
PubMed ID: 16276359
One-year prevention program linked higher fiber density with better weight/waist outcomes, an indicator of long-term health benefit (associative).
- Effectiveness of a lifestyle intervention on metabolic syndrome. A randomized controlled trial
PubMed ID: 17922167
Lifestyle change emphasizing higher fiber led to large 1-year reductions in metabolic syndrome and incident diabetes.
- Telephone counseling helps maintain long-term adherence to a high-vegetable dietary pattern
PubMed ID: 17885013
Large randomized behavioral intervention achieved sustained increases in fiber intake and biomarkers over 4 years—strong evidence for long-term adoption and wellness benefits.
- Effect of a high-fiber diet vs a fiber-supplemented diet on C-reactive protein level
PubMed ID: 17353499
High-fiber diet reduced CRP, an inflammatory marker linked to long-term health outcomes.
- Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study
PubMed ID: 17761020
Microbiota improvements from whole-grain fiber can contribute to long-term health via gut-mediated mechanisms.
- The benefits of early intervention in obese diabetic patients with FBCx: a new dietary fibre
PubMed ID: 17013969
FBCx produced weight maintenance and favorable metabolic changes (adiponectin, lipids in subgroup), consistent with long‑term wellness support.
- Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients
PubMed ID: 17308252
Reduced infections and improved gut integrity in critically ill patients imply important long‑term health-related benefits from synbiotic fibers in that clinical context.
- Randomised study to compare the efficacy and safety of isapgol plus atorvastatin versus atorvastatin alone in subjects with hypercholesterolaemia
PubMed ID: 17824470
Additional LDL‑C lowering with psyllium plus statin indicates contribution to long‑term cardiovascular risk reduction.
- Comparison of a dietary portfolio diet of cholesterol-lowering foods and a statin on LDL particle size phenotype in hypercholesterolaemic participants
PubMed ID: 17663803
The cholesterol‑lowering diet portfolio that included soluble fiber produced clinically meaningful LDL reductions—relevant to long‑term cardiovascular wellness (multi-component intervention).
- Comparison of early enteral nutrition in severe acute pancreatitis with prebiotic fiber supplementation versus standard enteral solution: a prospective randomized double-blind study
PubMed ID: 17569144
Prebiotic fiber produced clinically meaningful short-term recovery benefits in severe pancreatitis; these improvements could contribute to better long-term outcomes, though long-term data are absent.
- Telephone counseling for physical activity and diet in primary care patients
PubMed ID: 19062240
Sustained increases in fiber/produce intake via telephone counseling could contribute to long‑term wellness through dietary change.
- Dietary pattern influences breast cancer prognosis in women without hot flashes: the women's healthy eating and living trial
PubMed ID: 19075284
Large randomized dietary trial that raised fiber intake as part of a low‑fat, high‑fruit/veg program was associated with fewer breast‑cancer events in a subgroup—meaningful long‑term clinical signal (multifactorial intervention).
- The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome
PubMed ID: 18175740
Whole‑grain intake reduced abdominal fat and systemic inflammation (CRP) during weight loss — outcomes that support long‑term metabolic and cardiovascular wellness.
- A low-fat vegan diet elicits greater macronutrient changes, but is comparable in adherence and acceptability, compared with a more conventional diabetes diet among individuals with type 2 diabetes
PubMed ID: 19167953
High‑fiber vegan diet produced clinically meaningful long‑term metabolic improvements (weight, HbA1c) relevant to wellness.
- Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk
PubMed ID: 19289389
Higher fiber intake linked to sustained improvements in weight, BP, glucose and cholesterol in a large intervention—broad wellness benefits.
- The effect of strict adherence to a high-fiber, high-fruit and -vegetable, and low-fat eating pattern on adenoma recurrence
PubMed ID: 19643809
Long‑term high‑fiber, fruit/veg, low‑fat dietary adherence associated with substantially lower adenoma recurrence over 4 years.
- Prevention of type 2 diabetes in adults with impaired glucose tolerance: the European Diabetes Prevention RCT in Newcastle upon Tyne, UK
PubMed ID: 19758428
Lifestyle program increasing fiber contributed to reduced progression to diabetes in impaired glucose tolerance participants (multi‑factorial).
- Sleep duration, lifestyle intervention, and incidence of type 2 diabetes in impaired glucose tolerance: The Finnish Diabetes Prevention Study
PubMed ID: 19651919
Multi‑component lifestyle including increased fiber reduced inflammation and modified diabetes risk—supports long‑term health.
- A randomized lifestyle intervention with 5-year follow-up in subjects with impaired glucose tolerance: pronounced short-term impact but long-term adherence problems
PubMed ID: 19181821
A residential lifestyle program that increased fiber intake achieved pronounced short-term metabolic improvements and some lasting behavior change for wellness.
- Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study
PubMed ID: 19130041
Increased natural fiber intake (part of lifestyle changes) independently predicted reductions in CRP/IL-6, supporting long-term cardiometabolic wellness.
- Dietary change and reduced breast cancer events among women without hot flashes after treatment of early-stage breast cancer: subgroup analysis of the Women's Healthy Eating and Living Study
PubMed ID: 19339393
A diet higher in vegetables/fruit/fiber and lower in fat was associated with fewer subsequent breast cancer events in some subgroups — suggests long‑term benefits of fiber‑rich diets in certain populations.
- Adopting a plant-based diet minimally increased food costs in WHEL Study
PubMed ID: 19296743
Large randomized dietary intervention achieved sustained increases in fiber and plant-food intake—substantial support for long-term wellness via diet.
- NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
PubMed ID: 21164548
NUTRIOSE RCT improved glycemic control, lipids and body composition — supportive of long-term wellness if sustained.
- Dietary fiber does not displace energy but is associated with decreased serum cholesterol concentrations in healthy children
PubMed ID: 20071642
Longitudinal cohort from infancy to age 9: higher dietary fiber associated with lower cholesterol and no growth impairment — good evidence for long-term wellness support in children.
- Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods
PubMed ID: 20102847
Cholesterol and waist improvements from oat β‑glucan during weight loss suggest benefits relevant to long‑term health.
- Insoluble carob fiber rich in polyphenols lowers total and LDL cholesterol in hypercholesterolemic sujects
PubMed ID: 20094802
Rapid, large LDL/total cholesterol reductions from carob fiber imply potential long‑term CV risk reduction though trial was short (supportive but short‑term evidence).
- Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial
PubMed ID: 20413122
Psyllium improved several cardiometabolic markers (lipids, insulin, BP) that contribute to long-term health.
- A pilot comprehensive lifestyle intervention program (CLIP)--comparison with qualitative lifestyle advice and simvastatin on cardiovascular risk factors in overweight hypercholesterolaemic individuals
PubMed ID: 20110160
Structured lifestyle/functional-foods program (including fiber) improved short-term weight and LDL—supports long-term risk-factor management if sustained.
- Effects of lifestyle modification on oxidized LDL, reactive oxygen species production and endothelial cell viability in patients with coronary artery disease
PubMed ID: 20416290
High-fiber-containing lifestyle intervention improved oxidative stress and endothelial markers in CAD patients—consistent with long-term risk reduction (multicomponent).
- Linking long-term dietary patterns with gut microbial enterotypes
PubMed ID: 21885731
Long‑term high‑fiber dietary patterns strongly associated with favorable microbiome enterotypes—implications for chronic health.
- Comparison of high protein and high fiber weight-loss diets in women with risk factors for the metabolic syndrome: a randomized trial
PubMed ID: 21524314
Sustained high‑fiber wholefood diet improved metabolic markers and produced weight/fat loss—supports long‑term health.
- Randomized controlled trial to improve adiposity, inflammation, and insulin resistance in obese African-American and Latino youth
PubMed ID: 21293446
16‑week program increasing fiber/reducing sugar improved insulin sensitivity and hepatic fat—meaningful long‑term wellness implications.
- A diet, physical activity, and stress reduction intervention in men with rising prostate-specific antigen after treatment for prostate cancer
PubMed ID: 22018935
Lifestyle program increased fiber and other healthy behaviors with exploratory links to favorable biomarker trends—indirect evidence for long-term wellness support.
- Improving the diet of employees at blue-collar worksites: results from the 'Food at Work' intervention study
PubMed ID: 21208479
Worksite intervention produced measurable, sustained increases in fiber and fruit intake—behavioral changes that support long-term wellness.
- Effects of dietary counselling on food habits and dietary intake of Finnish pregnant women at increased risk for gestational diabetes - a secondary analysis of a cluster-randomized controlled trial
PubMed ID: 22735030
Dietary counselling led to modest but sustained healthier food choices and a small fiber increase, aligning with long‑term wellness goals.
- Randomized controlled trial of oatmeal consumption versus noodle consumption on blood lipids of urban Chinese adults with hypercholesterolemia
PubMed ID: 22866937
Oatmeal intervention improved lipid profile and waist circumference—cardiometabolic changes supportive of long‑term health.
- Effect of legumes as part of a low glycemic index diet on glycemic control and cardiovascular risk factors in type 2 diabetes mellitus: a randomized controlled trial
PubMed ID: 23089999
Legume‑based, higher‑fiber dietary change improved glycemic control and CHD risk markers—relevant to long‑term wellness.
- Effect of a mixture of inulin and fructo-oligosaccharide on Lactobacillus and Bifidobacterium intestinal microbiota of patients receiving radiotherapy: a randomised, double-blind, placebo-controlled trial
PubMed ID: 23588438
Prebiotic accelerated microbiota recovery after radiotherapy—supportive of recovery and long‑term gut health.
- Dietary associations with prediabetic states--the DR's EXTRA Study (ISRCTN45977199)
PubMed ID: 22415336
Observational evidence linking higher dietary/cereal fiber to lower odds of impaired glucose tolerance — supports long-term metabolic health.
- Persimmon fruit tannin-rich fiber reduces cholesterol levels in humans
PubMed ID: 23171573
Sustained reductions in LDL/total cholesterol with persimmon fiber suggest potential long‑term cardiovascular benefit.
- Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial
PubMed ID: 22848584
Psyllium lowered LDL and improved fat distribution in adolescents, indicating beneficial risk‑factor modification for long‑term health.
- Ribosomal therapy in patients with pharyngolaryngeal reflux
PubMed ID: 22497598
Sustained adoption of a plant‑based higher‑fiber diet in men correlated with slower PSA doubling time, suggesting broader long‑term benefits (small cohort).
- Improvement effect of resistant maltodextrin in humans with metabolic syndrome by continuous administration
PubMed ID: 23419401
Twelve‑week metabolic improvements (visceral fat, glucose, TG) with resistant maltodextrin suggest contributions to longer‑term cardiometabolic health if sustained.
- Intakes of dietary fiber, vegetables, and fruits and incidence of cardiovascular disease in Japanese patients with type 2 diabetes
PubMed ID: 24170762
Higher dietary fiber linked with substantially lower stroke risk in people with T2D — strong long-term health implication.
- Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial
PubMed ID: 24332524
Prebiotic fiber improved glycemia and reduced inflammation/endotoxin — benefits that support long-term health in T2D.
- Dietary outcomes in a Spanish-language randomized controlled diabetes prevention trial with pregnant Latinas
PubMed ID: 23763411
Behavioral intervention increased fiber intake in pregnant Latinas — supports sustained dietary change for long-term health.
- Fruit intake and incident diabetic retinopathy with type 2 diabetes
PubMed ID: 23348071
Observational cohort: higher fruit (and correlated fiber) intake associated with lower risk of incident diabetic retinopathy over 8 years—supports long‑term benefits of fiber‑rich diets.
- A natural fiber complex reduces body weight in the overweight and obese: a double-blind, randomized, placebo-controlled study
PubMed ID: 23505169
RCT showing clinically meaningful weight and waist reductions with a fiber complex—long‑term weight control supports overall wellness.
- Infancy-onset dietary counseling of low-saturated-fat diet improves insulin sensitivity in healthy adolescents 15-20 years of age: the Special Turku Coronary Risk Factor Intervention Project (STRIP) study
PubMed ID: 23801725
Long childhood dietary counseling with higher fiber correlated with modest persistent improvements in insulin sensitivity into adolescence — supports long-term wellness potential.
- Lifestyle intervention reduces body weight and improves cardiometabolic risk factors in worksites
PubMed ID: 23426035
Large workplace program including high-fiber diet produced durable weight and cardiometabolic improvements consistent with long-term health benefits (multi-component).
- Improvement of fasting plasma glucose level after ingesting moderate amount of dietary fiber in Japanese men with mild hyperglycemia and visceral fat obesity
PubMed ID: 23725526
Sustained (12-week) modest improvements in fasting glucose and weight/BMI imply potential long-term health benefits from regular fiber supplementation.
- Changes in visceral adiposity and serum cholesterol with a novel viscous polysaccharide in Japanese adults with abdominal obesity
PubMed ID: 23512917
PGX reduced LDL cholesterol and abdominal adiposity—markers linked to long‑term cardiometabolic health.
- Lowering dietary glycaemic index through nutrition education among Malaysian women with a history of gestational diabetes mellitus
PubMed ID: 24800381
Education‑driven modest increases in fiber intake could contribute to long‑term wellness if sustained.
- Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
PubMed ID: 25500202
Sustained 24‑week prevention of weight gain and reduced visceral/liver fat supports longer‑term metabolic health.
- Fiber intake and plasminogen activator inhibitor-1 in type 2 diabetes: Look AHEAD (Action for Health in Diabetes) trial findings at baseline and year 1
PubMed ID: 25131348
Habitual higher fiber intake associated with lower PAI-1 (cardio-metabolic marker) in a large cohort—supports long-term risk reduction (associative).
- Regular breakfast consumption and type 2 diabetes risk markers in 9- to 10-year-old children in the child heart and health study in England (CHASE): a cross-sectional analysis
PubMed ID: 25181492
High-fiber breakfast consumption linked to lower insulin resistance in children—implications for long-term metabolic health.
- Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber
PubMed ID: 25646321
Whole-grain wheat increased beneficial biomarkers and reduced TNF-α (inflammation reduction relates to long-term health benefits).
- Intensive low-glycaemic-load dietary intervention for the management of glycaemia and serum lipids among women with gestational diabetes: a randomized control trial
PubMed ID: 25222105
Sustained improvements in glycemia and some lipids on a higher‑fiber, low‑GL diet in gestational diabetes support long‑term metabolic wellness.
- Resistant starch type 4-enriched diet lowered blood cholesterols and improved body composition in a double blind controlled cross-over intervention
PubMed ID: 24478107
RS4 replacement produced durable metabolic improvements (cholesterol, body composition) over 26 weeks — supports long‑term wellness.
- Whole-grain intake in middle school students achieves dietary guidelines for Americans and MyPlate recommendations when provided as commercially available foods: a randomized trial
PubMed ID: 24948336
Successfully increasing whole‑grain (fiber) intake among adolescents establishes a foundation for long‑term wellness.
- Lifestyle intervention and cardiovascular disease risk reduction in low-income Hispanic immigrant women participating in the Illinois WISEWOMAN program
PubMed ID: 24469546
Sustained increase in fiber intake from a lifestyle program accompanied by a small long-term BMI drop—relevant to long-term wellness.
- Dietary outcomes of a community based intervention for mothers of young children: a randomised controlled trial
PubMed ID: 25245213
A behavioral home program increased fiber-related behaviors and fruit/veg intake over 6 months—supports sustained healthy habits.
- Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity
PubMed ID: 24997634
Dietary intervention improving lipids and glucose in children suggests longer-term cardiometabolic wellness benefits from higher fiber intake.
- Long-term changes in dietary and food intake behaviour in the Diabetes Prevention Program Outcomes Study
PubMed ID: 24824893
DPP/DPPOS lifestyle arm sustained higher fiber intake and better nutrient profiles for years—supports long‑term wellness as part of lifestyle change.
- Evidence supporting a promotora-delivered entertainment education intervention for improving mothers' dietary intake: the Entre Familia: Reflejos de Salud Study
PubMed ID: 25375276
Large behavioral RCT increased vegetable and fiber‑related behaviors — supports long‑term dietary changes linked to wellness.
- Influence of dietary fat and carbohydrates proportions on plasma lipids, glucose control and low-grade inflammation in patients with type 2 diabetes-The TOSCA.IT Study
PubMed ID: 26303195
Higher fiber intake in people with T2D associated with better lipids, lower HbA1c and lower CRP—evidence consistent with long‑term health benefits.
- A multifunctional diet improves cardiometabolic-related biomarkers independently of weight changes: an 8-week randomized controlled intervention in healthy overweight and obese subjects
PubMed ID: 26370118
Large LDL/total cholesterol reductions from a diet including viscous fibers suggest long‑term cardiometabolic wellness benefits (multiple components involved).
- Dietary protein-fiber ratio associates with circulating levels of indoxyl sulfate and p-cresyl sulfate in chronic kidney disease patients
PubMed ID: 26026209
Higher dietary fiber associated with lower gut‑derived uremic toxins in CKD patients, implying population‑level long‑term health relevance.
- Single-component versus multicomponent dietary goals for the metabolic syndrome: a randomized trial
PubMed ID: 25686165
Year‑long fiber goal trial produced modest weight/metabolic improvements, supporting long‑term wellness potential of increased fiber intake.
- Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial
PubMed ID: 26529006
Infant formula with fructans improved gut microbiota and lipid markers—effects relevant to longer‑term health trajectories.
- Weight Maintenance with Litramine (IQP-G-002AS): A 24-Week Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 26435849
Sustained weight/fat benefits and increased satiety over 24 weeks suggest longer-term wellness support when used as part of lifestyle.
- Processes of behavior change and weight loss in a theory-based weight loss intervention program: a test of the process model for lifestyle behavior change
PubMed ID: 25592314
Behavioral program produced sustained fiber intake increases and short‑term weight loss—supports longer‑term healthy habits and wellness.
- Reduction in food away from home is associated with improved child relative weight and body composition outcomes and this relation is mediated by changes in diet quality
PubMed ID: 25963602
Behavioral increase in fiber intake among families accompanied improvements in BMI/body fat in children—supports long‑term health trajectories.
- Mediators and Moderators of the Effectiveness of a Community Health Worker Intervention That Improved Dietary Outcomes in Pregnant Latino Women
PubMed ID: 25636316
CHW intervention produced sustained increases in fiber and reductions in added sugar/fat in pregnant women—supports healthier long‑term patterns.
- Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial
PubMed ID: 27810310
Combination prebiotic+probiotic produced modest body fat and waist reductions and lower energy intake—markers relevant to long‑term health.
- Short- and Long-Term Effects of Wholegrain Oat Intake on Weight Management and Glucolipid Metabolism in Overweight Type-2 Diabetics: A Randomized Control Trial
PubMed ID: 27618090
Sustained improvements in postprandial glucose and HbA1c at 1 year with oats support longer‑term metabolic health.
- Effects of a home-based intervention on diet and physical activity behaviours for rural adults with or at risk of metabolic syndrome: a randomised controlled trial
PubMed ID: 26830197
Home‑based lifestyle program produced sustained increases in fiber and activity over 6 months—behavioral evidence for long‑term wellness support.
- Sex differences in food choices, adherence to dietary recommendations and plasma lipid profile in type 2 diabetes - The TOSCA.IT study
PubMed ID: 27212622
Large observational evidence linking higher fiber adherence to better lipid profiles in T2D—supports long‑term cardiometabolic wellness.
- Effects of a Group-Based Behavioral Intervention on Dietary Behaviors in Older Adults
PubMed ID: 27634838
Group behavioral nutrition program improved fiber‑related behaviors in older adults—supports sustained dietary changes beneficial for long‑term health.
- Effects of oat bran and nutrition counseling on the lipid and glucose profile and anthropometric parameters of hypercholesterolemia patients
PubMed ID: 27019267
Oat bran improved LDL and insulin resistance metrics over 90 days—changes that support long‑term cardiometabolic wellness when sustained.
- Intervention leads to improvements in the nutrient profile of snacks served in afterschool programs: a group randomized controlled trial
PubMed ID: 27528522
Large afterschool intervention reduced snack calories and increased fiber—population‑level dietary improvements that support long‑term wellness.
- Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study
PubMed ID: 28376899
Oat β‑glucan lowered LDL and total cholesterol — a long‑term cardiovascular risk modifier.
- A High-Carbohydrate, High-Fiber, Low-Fat Diet Results in Weight Loss among Adults at High Risk of Type 2 Diabetes
PubMed ID: 28954840
Large trial cohort found high‑fiber carbohydrate intake predicted sustained weight loss—important for long‑term health outcomes.
- Effects of supplementation with rice husk powder and rice bran on inflammatory factors in overweight and obese adults following an energy-restricted diet: a randomized controlled trial
PubMed ID: 29063186
Rice husk/bran lowered inflammatory markers in overweight/obese adults, which may reduce long‑term cardiometabolic risk.
- Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial
PubMed ID: 29162875
A fibre‑rich diet (with exercise) produced large reductions in liver fat and improved insulin sensitivity—benefits with long‑term health implications.
- Impact of a Plant-Based Diet and Support on Mitigating Type 2 Diabetes Mellitus in Latinos Living in Medically Underserved Areas
PubMed ID: 28503930
High‑fiber, low‑fat plant diet improved long‑term glycemic control in people with diabetes, supporting chronic disease risk reduction.
- Effects of a physical activity and nutrition program in retirement villages: a cluster randomised controlled trial
PubMed ID: 28697803
6-month lifestyle program in retirement villages produced sustained increases in fiber-related dietary behavior, supporting long-term wellness.
- Short-Term Supplementation of a Moderate Carbohydrate Diet with Psyllium Reduces Fasting Plasma Insulin and Tumor Necrosis Factor-α in Patients with Type 2 Diabetes Mellitus
PubMed ID: 28956658
Psyllium improved insulin and inflammatory markers in T2D, changes relevant to long-term metabolic wellness.
- Chain length-dependent effects of inulin-type fructan dietary fiber on human systemic immune responses against hepatitis-B
PubMed ID: 28586162
Inulin-type fiber modulation of immune responses suggests a pathway by which fiber can support long-term health.
- Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention
PubMed ID: 28883543
High‑fiber diet produced clinically meaningful fat and waist reductions in a subgroup — potential contribution to long‑term wellness.
- Improvement in cardiometabolic risk markers following a multifunctional diet is associated with gut microbial taxa in healthy overweight and obese subjects
PubMed ID: 29098426
Marked LDL and total cholesterol reductions with a high‑fiber diet support long‑term cardiovascular wellness.
- Dietary quality and carotid intima media thickness in type 1 and type 2 diabetes: Follow-up of a randomised controlled trial
PubMed ID: 29853429
Higher diet quality/fiber associated with modest carotid IMT regression over 2 years (CV surrogate)
- Dietary and Physical Activity Interventions for Colorectal Cancer Survivors: A Randomized Controlled Trial
PubMed ID: 29636539
Behavioral program produced sustained improvements in diet (less refined grain) over 24 months
- Effects of supplemented isoenergetic diets varying in cereal fiber and protein content on the bile acid metabolic signature and relation to insulin resistance
PubMed ID: 29549243
Cereal fiber improved insulin sensitivity (metabolic risk reduction relevant to long-term health)
- Obesity and mental health improvement following nutritional education focusing on gut microbiota composition in Japanese women: a randomised controlled trial
PubMed ID: 30523432
Education increasing fiber intake yielded weight, waist and mood improvements (holistic benefits)
- Weight loss and metabolic health effects from energy-restricted Mediterranean and Central-European diets in postmenopausal women: A randomized controlled trial
PubMed ID: 30042488
Higher fiber increase associated with greater visceral fat loss under energy restriction—relevant to long‑term cardiometabolic risk reduction.
- Impact of Diets Rich in Whole Grains and Fruits and Vegetables on Cardiovascular Risk Factors in Overweight and Obese Women: A Randomized Clinical Feeding Trial
PubMed ID: 29702040
Whole-grain–rich diet improved multiple cardiometabolic risk factors, consistent with long‑term health benefits.
- Latina mothers as agents of change in children's eating habits: findings from the randomized controlled trial Entre Familia: Reflejos de Salud
PubMed ID: 30285755
Behavioral intervention increased fiber-related parental practices and improved children's diets—supports sustained healthy habits across life.
- Could resistant starch supplementation improve inflammatory and oxidative stress biomarkers and uremic toxins levels in hemodialysis patients? A pilot randomized controlled trial
PubMed ID: 30468238
Resistant starch reduced inflammation and uremic toxin load in hemodialysis patients—potential long-term health implications.
- A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects
PubMed ID: 30541093
Whole‑grain wheat prevented adverse liver-fat accumulation and preserved gut microbiota diversity—favorable long-term metabolic signals.
- A Plant-Based High-Carbohydrate, Low-Fat Diet in Overweight Individuals in a 16-Week Randomized Clinical Trial: The Role of Carbohydrates
PubMed ID: 30223451
Sustained improvement in weight, visceral fat and insulin resistance from a high-fiber plant-based diet indicates benefits for long-term wellness.
- Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals
PubMed ID: 29795366
Cohort linking higher IPA (a gut-microbial metabolite linked to fiber) with lower inflammation and reduced incident T2D supports long-term wellness mechanisms.
- Success in Achieving the Targets of the 20-Year Infancy-Onset Dietary Intervention: Association With Insulin Sensitivity and Serum Lipids
PubMed ID: 30072407
Long-term dietary counseling to meet fiber/whole-grain targets in childhood produced lasting improvements in insulin sensitivity and lipids — supportive of long-term health.
- A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
PubMed ID: 30425247
Sustained microbiome alterations, reduced fermentation and small weight loss suggest potential contributions to long‑term wellness.
- Effect of an individualised high-protein, energy-restricted diet on anthropometric and cardio-metabolic parameters in overweight and obese Malaysian adults: a 6-month randomised controlled study
PubMed ID: 30761964
Sustained weight loss and metabolic improvements on a higher‑fibre diet support long‑term health outcomes.
- Development and Efficacy of an Electronic, Culturally Adapted Lifestyle Counseling Tool for Improving Diabetes-Related Dietary Knowledge: Randomized Controlled Trial Among Ethnic Minority Adults With Type 2 Diabetes Mellitus
PubMed ID: 31621640
Sustained dietary counseling increased fiber and improved glycemic control in T2DM over 12 months—relevant to long‑term outcomes.
- Effects of dietary whole grain, fruit, and vegetables on weight and inflammatory biomarkers in overweight and obese women
PubMed ID: 31399910
High‑fiber whole‑food diets reduced inflammatory biomarkers in a randomized feeding trial—implicates long‑term health benefit.
- Pretreatment Prevotella-to-Bacteroides ratio and markers of glucose metabolism as prognostic markers for dietary weight loss maintenance
PubMed ID: 31285554
Strong RCT evidence that higher habitual fiber interacts with microbiome and metabolic health to reduce long‑term weight regain—relevant to sustained wellness.
- Weight loss at your fingertips: personalized nutrition with fasting glucose and insulin using a novel statistical approach
PubMed ID: 30967642
Dietary pattern high in fiber/whole grains (NND) produced greater weight loss in some people — implication for long-term health benefits.
- Pretreatment Fasting Glucose and Insulin as Determinants of Weight Loss on Diets Varying in Macronutrients and Dietary Fibers-The POUNDS LOST Study
PubMed ID: 30861997
Higher fiber intake during weight-loss interventions was associated with better long-term weight outcomes—implicates fiber in sustained health benefit and wellness.
- Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults: A Randomized Clinical Trial
PubMed ID: 33252690
Sustained metabolic improvements and weight loss on a high-fiber vegan diet indicate long-term wellness potential if maintained.
- Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort
PubMed ID: 32369545
Large prospective cohort: higher fiber intakes associated with lower risks of T2D, CVD, colorectal cancer and mortality—strong evidence for long-term wellness support.
- Visceral Fat-Reducing Effect and Safety of Continuous Consumption of Beverage Containing Resistant Maltodextrin: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial
PubMed ID: 33132344
Resistant maltodextrin reduced visceral fat in an RCT—modest evidence that a fiber supplement can contribute to long-term cardiometabolic risk reduction.
- Lifestyle intervention for Latina cancer survivors and caregivers: the Nuestra Salud randomized pilot trial
PubMed ID: 33170481
Phone‑based lifestyle coaching raised fiber intake and reduced symptom burden in a pilot randomized program—supportive of longer‑term wellness.
- Carbohydrate quality changes and concurrent changes in cardiovascular risk factors: a longitudinal analysis in the PREDIMED-Plus randomized trial
PubMed ID: 31868210
Large trial linking improved carbohydrate quality (including higher fiber) to sustained cardiometabolic improvements over 12 months.
- A Remote Nutritional Intervention to Change the Dietary Habits of Patients Undergoing Ablation of Atrial Fibrillation: Randomized Controlled Trial
PubMed ID: 33284131
Remote Mediterranean program increased fiber intake long‑term in a large RCT population—behavioral and dietary sustainability evidence.
- Impact of the Dietary Approaches to Stop Hypertension (DASH) diet on glycaemic control and consumption of processed and ultraprocessed foods in pregnant women with pre-gestational diabetes mellitus: a randomised clinical trial
PubMed ID: 33256869
Adapted DASH diet (higher in fiber) improved diabetes glycaemic control and reduced ultraprocessed food intake, supporting long‑term health outcomes.
- Effects of Health Risk Assessment and Counselling on Fruit and Vegetable Intake in Older People: A Pragmatic Randomised Controlled Trial
PubMed ID: 32510111
Geriatric counseling produced clinically meaningful, sustained increases in fruit/vegetable (fiber) intake—supports long‑term health behaviors.
- Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial
PubMed ID: 32521538
SCFA delivery produced durable physiological effects on stress response (HPA axis), suggesting a pathway by which fiber fermentation can support long‑term wellness.
- Human clinical trial to assess the effect of consumption of multigrain Indian bread on glycemic regulation in type 2 diabetic participants
PubMed ID: 33006193
Multigrain substitution improved glycemic control and LDL in T2DM, changes relevant to long-term cardiometabolic risk reduction.
- Promotion of optimized food-based recommendations to improve dietary practices and nutrient intakes among Minangkabau women of reproductive age with dyslipidemia
PubMed ID: 32674241
Community food-recommendation intervention increased fiber intake and healthier fats in dyslipidemic women—population-level support for long-term wellness.
- Replacing Animal-Based Proteins with Plant-Based Proteins Changes the Composition of a Whole Nordic Diet-A Randomised Clinical Trial in Healthy Finnish Adults
PubMed ID: 32231103
Dietary changes that increased fiber and lowered LDL/total cholesterol support long‑term cardiovascular risk reduction and wellness.
- Dietary Fibres and the Management of Obesity and Metabolic Syndrome: The RESOLVE Study
PubMed ID: 32977595
Sustained increases in fiber during a structured weight‑loss program were linked to durable improvements in body composition and metabolic markers, supporting long‑term wellness.
- Attainment of Targets of the 20-Year Infancy-Onset Dietary Intervention and Blood Pressure Across Childhood and Young Adulthood: The Special Turku Coronary Risk Factor Intervention Project (STRIP)
PubMed ID: 32921196
Longitudinal trial found diets meeting whole‑grain/produce targets (higher fiber) were associated with slightly lower blood pressure into young adulthood — population‑level wellness benefit.
- Dietary Blueberry and Soluble Fiber Supplementation Reduces Risk of Gestational Diabetes in Women with Obesity in a Randomized Controlled Trial
PubMed ID: 33693835
Soluble fiber + blueberries reduced gestational weight gain and inflammation, suggesting longer‑term maternal health benefits.
- A hypocaloric diet rich in high fiber rye foods causes greater reduction in body weight and body fat than a diet rich in refined wheat: A parallel randomized controlled trial in adults with overweight and obesity (the RyeWeight study)
PubMed ID: 34620312
High‑fiber rye in calorie restriction increased weight/fat loss and lowered CRP over 12 weeks — changes that contribute to long‑term health.
- Daily apple consumption reduces plasma and peripheral blood mononuclear cell-secreted inflammatory biomarkers in adults with overweight and obesity: a 6-week randomized, controlled, parallel-arm trial
PubMed ID: 33964852
Daily apples reduced systemic inflammation biomarkers over 6 weeks — anti‑inflammatory effects support long‑term health.
- Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial
PubMed ID: 33861390
Psyllium lowered sdLDL and IL‑6 in adolescents — markers relevant to long‑term cardiometabolic health.
- Factors associated with successful dietary changes in an energy-reduced Mediterranean diet intervention: a longitudinal analysis in the PREDIMED-Plus trial
PubMed ID: 34846603
Baseline fiber intake predicted sustained adherence to an improved diet over 6–12 months — behaviorally relevant to long‑term health.
- Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention-Association with Metabolic Profile from Childhood to Adulthood
PubMed ID: 33562015
Longitudinal observation showing that meeting dietary targets including higher fiber across childhood/adolescence associated with better lipid and metabolic profiles — supports long-term health.
- Usefulness of MCP-1 Chemokine in the Monitoring of Patients with Coronary Artery Disease Subjected to Intensive Dietary Intervention: A Pilot Study
PubMed ID: 34578925
DASH dietary intervention with higher plant-derived fiber decreased MCP-1 (inflammation) and correlated with fiber intake — relevant for long-term cardiometabolic wellness.
- Flaxseed Mucilage (IQP-LU-104) Reduces Body Weight in Overweight and Moderately Obese Individuals in a 12-week, Three-Arm, Double-Blind, Randomized, and Placebo-Controlled Clinical Study
PubMed ID: 35130547
Flaxseed mucilage RCT showing sustained weight/fat loss over 12 weeks supports longer‑term wellness if effects persist with use.
- Effect of a Nutritional Support System to Increase Survival and Reduce Mortality in Patients with COVID-19 in Stage III and Comorbidities: A Blinded Randomized Controlled Clinical Trial
PubMed ID: 35162195
Inpatient inulin+probiotic support produced markedly better clinical outcomes (survival/ventilation) — indicates potential for meaningful wellness impacts in acute illness.
- Diverging metabolic effects of 2 energy-restricted diets differing in nutrient quality: a 12-week randomized controlled trial in subjects with abdominal obesity
PubMed ID: 35102369
Higher‑quality (higher‑fiber) diet during energy restriction led to greater weight loss and better cardiometabolic changes — supports longer‑term wellness strategies.
- Changes in Food and Nutrient Intake and Diet Quality on a Low-Fat Vegan Diet Are Associated with Changes in Body Weight, Body Composition, and Insulin Sensitivity in Overweight Adults: A Randomized Clinical Trial
PubMed ID: 35452873
Sustained plant‑food (fiber) increases in a RCT were tied to weight and metabolic improvements relevant to long‑term health.
- Effects of Dietary Supplementation with Carrot-Derived Rhamnogalacturonan-I (cRG-I) on Accelerated Protective Immune Responses and Quality of Life in Healthy Volunteers Challenged with Rhinovirus in a Randomized Trial
PubMed ID: 36296939
Low‑dose carrot RG‑I fiber accelerated antiviral immune responses and reduced cold duration—suggests systemic long‑term wellness support potential.
- Does a Plant-Based Diet Stand Out for Its Favorable Composition for Heart Health? Dietary Intake Data from a Randomized Controlled Trial
PubMed ID: 36364858
Short RCT with PBD increased fiber and improved cardiometabolic risk factors—relevant to long‑term wellness.
- Longitudinal association of dietary carbohydrate quality with visceral fat deposition and other adiposity indicators
PubMed ID: 36084360
Large cohort linking better carbohydrate quality (fiber) to lower visceral/total fat implies long‑term metabolic/health benefits.
- Increasing the diversity of dietary fibers in a daily-consumed bread modifies gut microbiota and metabolic profile in subjects at cardiometabolic risk
PubMed ID: 35311446
Sustained multi‑fiber intake improved LDL and insulin sensitivity and beneficially altered gut microbes—changes that support long‑term cardiometabolic wellness.
- Effectiveness of a 6-Month Nutrition Intervention in People Living with HIV and Prediabetes Progressing through Stages of Change towards Positive Health Behavior
PubMed ID: 36429394
Behavioral counseling that increases fiber intake supports sustained dietary change and thus long‑term wellness (indirect intervention evidence).
- Facilitating a high-quality dietary pattern induces shared microbial responses linking diet quality, blood pressure, and microbial sterol metabolism in caregiver-child dyads
PubMed ID: 36457073
High‑fiber dietary provision improved diet quality and produced microbiome/metabolite shifts linked to BP—favourable for long‑term health.
- Impact of high prebiotic and probiotic dietary education in the SARS-CoV-2 era: improved cardio-metabolic profile in schizophrenia spectrum disorders
PubMed ID: 36510155
Sustained 6‑month dietary program improved weight/waist and metabolic syndrome components—supports longer‑term wellness if maintained.
- Oats Lower Age-Related Systemic Chronic Inflammation (iAge) in Adults at Risk for Cardiovascular Disease
PubMed ID: 36364734
β‑glucan lowering LDL and inflammaging score suggests plausible long‑term cardiometabolic wellness benefits.
- Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial
PubMed ID: 36599304
Dietary tailoring including higher fiber improved insulin sensitivity, lipids and inflammation in a large trial—relevant to long‑term chronic‑disease risk reduction.
- Effects of Synbiotic Supplementation on Metabolic Syndrome Traits and Gut Microbial Profile among Overweight and Obese Hong Kong Chinese Individuals: A Randomized Trial
PubMed ID: 37836532
Overweight/obese adults on a fiber‑rich diet achieved substantial weight loss and improved glycemia and microbiota—beneficial for long‑term health.
- The role of dietary fiber on preventing gestational diabetes mellitus in an at-risk group of high triglyceride-glucose index women: a randomized controlled trial
PubMed ID: 37737931
Large RCT in pregnancy showing marked reduction in GDM and preterm birth with daily fiber powder—strong long‑term health implications.
- Effect of nutritional promotion intervention on dietary adherence among type II diabetes patients in North Shoa Zone Amhara Region: quasi-experimental study
PubMed ID: 37254151
Six‑month diet promotion in T2D increased consumption of recommended (including high‑fiber) foods and improved FBS—supports chronic disease risk reduction.
- A Proof-of-Concept Pilot Test of a Behavioral Intervention to Improve Adherence to Dietary Recommendations for Cancer Prevention
PubMed ID: 37950612
mHealth dietary program produced sustained dietary improvements including fiber, which supports long‑term wellness when maintained.
- Low-protein diet supplemented with inulin lowers protein-bound toxin levels in patients with stage 3b-5 chronic kidney disease: a randomized controlled study
PubMed ID: 37409723
Inulin reduced protein‑bound uremic toxins and inflammation in CKD—changes that can support long‑term health outcomes.
- The ALINFA Intervention Improves Diet Quality and Nutritional Status in Children 6 to 12 Years Old
PubMed ID: 37242258
ALINFA child nutrition program increased fiber and improved anthropometrics/metabolic marker (leptin), supporting long‑term health trajectories.
- Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota
PubMed ID: 38409604
Resistant starch produced weight/fat loss, improved insulin sensitivity and reduced inflammation—benefits likely to support long‑term health.
- Effects of a diverse prebiotic fibre blend on inflammation, the gut microbiota and affective symptoms in metabolic syndrome: a pilot open-label randomised controlled trial
PubMed ID: 39411833
Prebiotic fibre lowered systemic inflammation and blood pressure—changes that support long‑term health risk reduction.
- Long-term clinical efficacy of dietary fiber supplementation in middle-aged and elderly prediabetic patients
PubMed ID: 39406174
Six‑month mixed fiber supplementation lowered glycemia and reduced diabetes incidence at 12 months, indicating long‑term health benefits.
- Effects of dietary fiber on maternal health in pregnant women with metabolic syndrome risk: a randomized controlled trial
PubMed ID: 38809131
Pregnancy trial: higher fiber and soluble fiber supplementation were associated with lower GDM risk and better metabolic/trust outcomes, implying long‑term benefit potential.
- Effects of a diverse prebiotic fibre supplement on HbA1c, insulin sensitivity and inflammatory biomarkers in pre-diabetes: a pilot placebo-controlled randomised clinical trial
PubMed ID: 38654680
Prebiotic fiber improved insulin sensitivity and reduced CRP in pre‑diabetes — changes relevant to long‑term cardiometabolic health.
- Impact of diet intervention on visceral adipose tissue and hepatic fat in patients with obesity or type 2 diabetes: a randomized trial
PubMed ID: 39271914
High‑fiber staple as part of a diet reduced visceral and hepatic fat and body weight — outcomes meaningful for long‑term metabolic health.
- Effects of the dyadic FirstStep2Health intervention on parents' behaviour and anthropometric outcomes: a secondary analysis of a cluster randomised trial
PubMed ID: 39638602
Behavioral intervention that raised parental fiber intake was linked to better body composition and lower BP—supports long‑term health.
- Adherence to a culturally adapted soul food vegan diet among African American adults increases diet quality compared to an omnivorous diet in the NEW Soul Study
PubMed ID: 38981142
Culturally tailored vegan diet increased fiber intake and improved overall diet quality at 12 months—strong sign for long‑term wellness.
- Improving adolescents' dietary behavior through teacher-delivered cancer prevention education: a school-based cluster randomized intervention trial in urban Rajasthan
PubMed ID: 38413917
Large school cluster RCT produced durable increases in fruit/veg intake (fiber) and reductions in unhealthy food intake—behavioral change at population level supports long‑term wellness.
- A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial
PubMed ID: 39843443
Legume‑rich (high‑fibre) feeding improved HbA1c, LDL and body composition—markers tied to long‑term cardiometabolic wellness.
- Gut microbiome predicts personalized responses to dietary fiber in prediabetes: a randomized, open-label trial
PubMed ID: 41390484
Large randomized trial in prediabetes showed fiber supplementation produced sustained glycemic benefits in identifiable subgroups—relevant to long‑term disease risk.
- Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study
PubMed ID: 40057729
Sustained high‑fiber, improved‑fat diet yielded LDL and weight improvements that support long‑term health.
- Impact of a high dietary fiber cereal meal intervention on the progression of liver fibrosis in T2DM with MASLD
PubMed ID: 40958906
12‑week high‑fiber cereal improved glycemia and liver fibrosis markers in T2DM/MASLD, outcomes relevant to long‑term wellness.
- Dietary Fiber Intake and Prostate Cancer Outcomes and All-Cause Mortality: Findings From a Secondary Analysis of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Study
PubMed ID: 40684909
Large prospective cohort analysis linked higher dietary fiber (total and soluble) to lower all‑cause mortality—strong evidence for long‑term health benefit.
- Effects of defatted rice bran-fortified bread on gut microbiome, cardiovascular risk, gut discomfort, wellbeing and gut physiology in healthy adults with low dietary fibre intake
PubMed ID: 40127766
Major increase in dietary fiber from rice‑bran‑fortified bread improved HDL and cholesterol ratio—cardiometabolic benefit relevant to long‑term wellness.
- Supplementing the standard diet with brown rice bran powder might effectively improve the metabolic syndrome characteristics and antioxidant status: an open label randomized controlled trial
PubMed ID: 39775811
Brown rice bran improved metabolic syndrome parameters (weight, LDL, glucose) that relate to long‑term health.
- NUTRIOSE® soluble fibre supplementation as an effective dietary strategy to improve glycaemic response
PubMed ID: 40167751
NUTRIOSE improved glycaemic control and body composition measures—beneficial for long‑term metabolic health.
- Fibre-Enriched High-Carbohydrate (FEHC) Diet Modulates Inflammation Without Affecting Bone Health in Older Women With Obesity: A Randomised Clinical Trial
PubMed ID: 41026958
Longer dietary intervention with higher fiber reduced systemic inflammatory markers in older women with obesity — relevant to long‑term health.
- Development and empirical evaluation of a dietary intervention programme for individuals with prediabetes based on the health action process approach: A randomised controlled trial
PubMed ID: 41421300
Prediabetes program increased fibre intake and improved BMI and glucose—supports long‑term cardiometabolic wellness.
Heart health (285)
- Co-administration of a konjac-based fibre blend and American ginseng (Panax quinquefolius L.) on glycaemic control and serum lipids in type 2 diabetes: a randomized controlled, cross-over clinical trial
PubMed ID: 28687934
Konjac blend reduced LDL and non‑HDL cholesterol in type 2 diabetes patients.
- Effect on Insulin, Glucose and Lipids in Overweight/Obese Australian Adults of 12 Months Consumption of Two Different Fibre Supplements in a Randomised Trial
PubMed ID: 28146065
PGX and psyllium produced significant short‑term reductions in total and LDL cholesterol in overweight/obese adults.
- The Effect of a Diet Moderately High in Protein and Fiber on Insulin Sensitivity Measured Using the Dynamic Insulin Sensitivity and Secretion Test (DISST)
PubMed ID: 29186908
Higher-protein, higher-fiber diet improved body composition and serum lipids modestly, which can support heart health.
- Improvement in cardiometabolic risk markers following a multifunctional diet is associated with gut microbial taxa in healthy overweight and obese subjects
PubMed ID: 29098426
8‑week high‑fiber multifunctional diet produced large LDL and total cholesterol reductions (LDL −34%).
- Dietary quality and carotid intima media thickness in type 1 and type 2 diabetes: Follow-up of a randomised controlled trial
PubMed ID: 29853429
Observational link between higher fiber intake and reduced carotid intima–media thickness
- A randomized controlled-feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indexes
PubMed ID: 30101333
Higher-quality (fiber-rich) DGA diet produced meaningful systolic BP reduction in controlled feeding
- Impact of Diets Rich in Whole Grains and Fruits and Vegetables on Cardiovascular Risk Factors in Overweight and Obese Women: A Randomized Clinical Feeding Trial
PubMed ID: 29702040
Whole-grain–rich diet produced superior improvements in lipids (TG, HDL) and BP—direct cardiometabolic benefit.
- A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects
PubMed ID: 30541093
Whole‑grain wheat prevented liver-fat increase and preserved microbiota—metabolic effects relevant to cardiovascular risk.
- A Plant-Based High-Carbohydrate, Low-Fat Diet in Overweight Individuals in a 16-Week Randomized Clinical Trial: The Role of Carbohydrates
PubMed ID: 30223451
Plant-based, high-fiber diet reduced weight, visceral fat and HOMA-IR, all favorable for cardiovascular risk though direct lipid/BP changes not primary endpoints.
- [Comparison of a commercially available, formula-based nutritional therapy enriched with oats fiber with a non-formula isocaloric therapy to treat non-alcoholic fatty liver disease (NAFLD) - a randomized, controlled intervention trial]
PubMed ID: 30304749
Oat-fiber–enriched formula reduced liver fat and produced significant systolic/diastolic blood pressure reductions vs isocaloric control — direct cardiovascular risk benefit.
- Success in Achieving the Targets of the 20-Year Infancy-Onset Dietary Intervention: Association With Insulin Sensitivity and Serum Lipids
PubMed ID: 30072407
Longitudinal counseling to meet whole-grain/fruit/veg/fiber targets improved insulin sensitivity and blood lipids in children — supports long-term heart health.
- Ameliorating Effects of Four-Week Fiber-Multivitamin Combination Treatment on Low-Density Lipoprotein Cholesterol, Total Cholesterol, and Apolipoprotein B Profiles in Hypercholesterolemic Participants
PubMed ID: 30380357
A fiber‑plus‑multivitamin product lowered LDL and ApoB (cardiovascular risk markers); multi‑ingredient design limits attribution to fiber alone.
- Effect of an individualised high-protein, energy-restricted diet on anthropometric and cardio-metabolic parameters in overweight and obese Malaysian adults: a 6-month randomised controlled study
PubMed ID: 30761964
Personalized high‑protein, higher‑fibre diet improved weight, insulin and inflammation—factors relevant to heart health risk reduction.
- No Effect of Glucomannan on Body Weight Reduction in Children and Adolescents with Overweight and Obesity: A Randomized Controlled Trial
PubMed ID: 31036412
Glucomannan lowered total and LDL cholesterol in children in an RCT (lipid benefit observed).
- Effects of dietary whole grain, fruit, and vegetables on weight and inflammatory biomarkers in overweight and obese women
PubMed ID: 31399910
High‑fiber (whole-grain/F&V) diets lowered inflammatory markers (CRP, TNF‑α, IL‑6), supportive of cardiovascular health.
- Snack selection influences glucose metabolism, antioxidant capacity and cholesterol in healthy overweight adults: A randomized parallel arm trial
PubMed ID: 30952505
Dried plum snack lowered LDL-C and improved postprandial insulin in an RCT—direct heart‑health signals.
- Effect of High Fiber Cereal Intake on Satiety and Gastrointestinal Symptoms during Ramadan
PubMed ID: 31027300
High‑fiber cereal during Ramadan attenuated rises in total and LDL cholesterol over 20 days (RCT).
- The effect of inulin and resistant maltodextrin on weight loss during energy restriction: a randomised, placebo-controlled, double-blinded intervention
PubMed ID: 31605197
Inulin + resistant maltodextrin supplementation produced modest but significant reductions in systolic and diastolic blood pressure—direct cardiovascular benefit.
- Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort
PubMed ID: 32369545
Large prospective cohort: higher total/soluble fiber associated with lower CVD incidence and mortality (strong observational evidence).
- A Whole-Diet Approach Affects Not Only Fasting but Also Postprandial Cardiometabolic Risk Markers in Overweight and Obese Adults: A Randomized Controlled Trial
PubMed ID: 33096554
Whole-diet higher in fruit/veg/whole grains/fiber lowered LDL, postprandial TAG/apoB48 and ambulatory systolic BP (cardiometabolic benefit including fiber).
- Two apples a day lower serum cholesterol and improve cardiometabolic biomarkers in mildly hypercholesterolemic adults: a randomized, controlled, crossover trial
PubMed ID: 31840162
Whole‑apple intervention (fiber + polyphenols) lowered total and LDL cholesterol and improved microvascular endothelial function.
- Effects of High-Fiber Biscuits on Lipid and Anthropometric Profile of Patients with Type 2 Diabetes
PubMed ID: 33612630
High-fibre biscuit trial in T2D produced meaningful reductions in total and LDL cholesterol (supports heart health).
- Defatted flaxseed flour improves weight loss and lipid profile in overweight and obese adults: a randomized controlled trial
PubMed ID: 32966475
Flaxseed (fiber‑rich) biscuits reduced triglycerides and inflammation during 60 days—favorable for cardiometabolic risk.
- Carbohydrate quality changes and concurrent changes in cardiovascular risk factors: a longitudinal analysis in the PREDIMED-Plus randomized trial
PubMed ID: 31868210
Large lifestyle trial: better carbohydrate quality (including higher fiber) linked to improvements in lipids and BP—cardiometabolic benefit.
- Impact of the Dietary Approaches to Stop Hypertension (DASH) diet on glycaemic control and consumption of processed and ultraprocessed foods in pregnant women with pre-gestational diabetes mellitus: a randomised clinical trial
PubMed ID: 33256869
Adapted DASH (higher‑fiber) diet improved glycaemic control and reduced ultraprocessed food intake, supportive of cardiovascular health (diet-level evidence).
- Human clinical trial to assess the effect of consumption of multigrain Indian bread on glycemic regulation in type 2 diabetic participants
PubMed ID: 33006193
Replacing bread with multigrain millet (higher-fiber) lowered fasting insulin, HbA1c and LDL in T2DM patients—direct cardiometabolic benefit (LDL reduction relevant to heart health).
- Replacing Animal-Based Proteins with Plant-Based Proteins Changes the Composition of a Whole Nordic Diet-A Randomised Clinical Trial in Healthy Finnish Adults
PubMed ID: 32231103
Replacing animal with plant protein increased fiber intake and produced significant decreases in total and LDL cholesterol — direct cardiovascular risk benefit.
- Effect of a functional fibre supplement on glycemic control when added to a year-long medically supervised weight management program in adults with type 2 diabetes
PubMed ID: 32642971
PGX viscous fiber reduced LDL at intermediate timepoints in a large trial (direct lipid benefit).
- A hypocaloric diet rich in high fiber rye foods causes greater reduction in body weight and body fat than a diet rich in refined wheat: A parallel randomized controlled trial in adults with overweight and obesity (the RyeWeight study)
PubMed ID: 34620312
High‑fiber rye in a hypocaloric program gave greater weight/fat loss and reduced CRP (inflammation), both favorable for heart health.
- The effect of dietary fiber (oat bran) supplement on blood pressure in patients with essential hypertension: A randomized controlled trial
PubMed ID: 34090773
Oat‑bran fiber RCT (~8.9 g/day) produced significant reductions in office and ambulatory blood pressure, a direct cardiovascular benefit.
- Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial
PubMed ID: 33861390
Psyllium (10 g/day) in obese adolescents reduced small dense LDL and IL‑6 → direct cardiovascular risk marker improvement.
- Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention-Association with Metabolic Profile from Childhood to Adulthood
PubMed ID: 33562015
Meeting dietary goals including higher fiber in children/adolescents associated with lower LDL-related lipids and healthier fatty-acid patterns — supports cardiovascular risk reduction.
- Usefulness of MCP-1 Chemokine in the Monitoring of Patients with Coronary Artery Disease Subjected to Intensive Dietary Intervention: A Pilot Study
PubMed ID: 34578925
DASH intervention (increased plant-derived fiber) significantly lowered MCP-1 (inflammatory chemokine) and changes correlated with fiber intake — relevant to CVD risk reduction.
- Consuming a Protein and Fiber-Based Supplement Preload Promotes Weight Loss and Alters Metabolic Markers in Overweight Adults in a 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 35212740
HPF supplement improved total cholesterol, LDL and ox‑LDL vs control in RCT (fiber part of intervention).
- Diverging metabolic effects of 2 energy-restricted diets differing in nutrient quality: a 12-week randomized controlled trial in subjects with abdominal obesity
PubMed ID: 35102369
Higher‑quality (higher‑fiber) energy‑restricted diet produced superior lipid improvements vs low‑quality diet.
- Does a Plant-Based Diet Stand Out for Its Favorable Composition for Heart Health? Dietary Intake Data from a Randomized Controlled Trial
PubMed ID: 36364858
Whole‑food PBD increased fiber and produced modest cardiometabolic improvements.
- Effect of Dietary Fiber (Oat Bran) Supplement in Heart Rate Lowering in Patients with Hypertension: A Randomized DASH-Diet-Controlled Clinical Trial
PubMed ID: 35956324
Oat‑bran (extra fiber) for 3 months reduced 24h and daytime heart rates in hypertensive patients (clinically meaningful).
- Increasing the diversity of dietary fibers in a daily-consumed bread modifies gut microbiota and metabolic profile in subjects at cardiometabolic risk
PubMed ID: 35311446
Multi‑fiber bread produced clinically meaningful LDL and total cholesterol reductions—direct heart‑health biomarker improvement.
- Facilitating a high-quality dietary pattern induces shared microbial responses linking diet quality, blood pressure, and microbial sterol metabolism in caregiver-child dyads
PubMed ID: 36457073
High‑fiber dietary intervention improved diet quality and was associated with changes linked to lower blood pressure.
- Oats Lower Age-Related Systemic Chronic Inflammation (iAge) in Adults at Risk for Cardiovascular Disease
PubMed ID: 36364734
Oat β‑glucan (3 g/day) reduced an inflammaging score and decreased LDL in a high‑risk subgroup—cardio‑relevant.
- Tapioca Resistant Maltodextrin as a Carbohydrate Source of Oral Nutrition Supplement (ONS) on Metabolic Indicators: A Clinical Trial
PubMed ID: 35267892
Resistant maltodextrin lowered postprandial insulin acutely and produced modest LDL reductions over 12 weeks—beneficial for heart health.
- Dietary Supplementation with Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), Reduces Visceral Fat and Hyperlipidemia in Inhabitants of a Rural Community in Mexico
PubMed ID: 36004709
Pleurotus (fiber‑rich mushroom) supplementation improved lipids in women in a small community trial.
- Effects of an Eating Pattern Including Colorful Fruits and Vegetables on Management of Gestational Diabetes: A Randomized Controlled Trial
PubMed ID: 37630814
Dietary intervention emphasizing berries/greens (fiber‑rich) raised HDL and improved glucose/inflammatory markers in gestational diabetes.
- Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial
PubMed ID: 36599304
Large RCT tailoring diets (higher fiber component) improved insulin sensitivity, triglycerides and inflammation—key heart‑health markers.
- Effect of daily ingestion of Bifidobacterium and dietary fiber on vascular endothelial function: a randomized, double-blind, placebo-controlled, parallel-group comparison study
PubMed ID: 37849220
Inulin + Bifidobacterium improved endothelial function (FMD) in healthy adults—direct cardiovascular benefit linked to a fiber (inulin) intervention.
- Consumption of Tree Nuts as Snacks Reduces Metabolic Syndrome Risk in Young Adults: A Randomized Trial
PubMed ID: 38140310
Tree‑nut replacement (multi‑nutrient, including fiber) improved cardiometabolic risk markers (MetS score, waist) though not fiber‑isolated.
- Effects of a diverse prebiotic fibre blend on inflammation, the gut microbiota and affective symptoms in metabolic syndrome: a pilot open-label randomised controlled trial
PubMed ID: 39411833
12‑week randomized trial of prebiotic fibre lowered systolic blood pressure and hs‑CRP in metabolic‑syndrome patients—relevant to cardiovascular risk.
- Long-term clinical efficacy of dietary fiber supplementation in middle-aged and elderly prediabetic patients
PubMed ID: 39406174
6‑month mixed fiber supplement improved metabolic markers (TG/HDL) and reduced diabetes incidence, which supports heart‑health risk reduction.
- Effects of dietary fiber on maternal health in pregnant women with metabolic syndrome risk: a randomized controlled trial
PubMed ID: 38809131
Pregnancy trial: higher dietary/soluble fiber associated with smaller triglyceride rises and cardiometabolic benefits.
- A Comparison of Dry Bean and Pea Consumption on Serum Cholesterol: A Randomized Controlled Trial in Adults with Mild Hypercholesterolemia
PubMed ID: 39357673
6‑week bean (high‑fiber pulse) RCT lowered LDL/non‑HDL/total cholesterol, supporting cardiovascular benefit.
- Type 3 resistant starch from Canna edulis reduce lipid levels in patients with mild hyperlipidemia through altering gut microbiome: A double- blind randomized controlled trial
PubMed ID: 38825157
12‑week RCT: resistant starch (20 g/day) reduced total cholesterol, LDL and non‑HDL in mild hyperlipidemia — direct lipid benefit relevant to heart health.
- Fasting and postprandial plasma metabolite responses to a 12-wk dietary intervention in tissue-specific insulin resistance: a secondary analysis of the PERSonalized glucose Optimization through Nutritional intervention (PERSON) randomized trial
PubMed ID: 38851634
12‑week randomized diet: low‑fat, high‑protein, high‑fiber diet reduced fasting and postprandial VLDL‑TAG measures vs high‑MUFA diet — favorable lipid effects linked to cardiovascular risk.
- Impact of diet intervention on visceral adipose tissue and hepatic fat in patients with obesity or type 2 diabetes: a randomized trial
PubMed ID: 39271914
High‑fiber staple substitution in a 12‑week diet reduced visceral and hepatic fat and body weight — improved cardiometabolic risk profile though study was multi‑component.
- Twelve Weeks of Daily Lentil Consumption Improves Fasting Cholesterol and Postprandial Glucose and Inflammatory Responses-A Randomized Clinical Trial
PubMed ID: 38337705
Daily lentil meals for 12 weeks lowered fasting total and LDL cholesterol and postprandial glucose/inflammation — supports cardiovascular risk reduction.
- A four-week dietary intervention with mycoprotein-containing food products reduces serum cholesterol concentrations in community-dwelling, overweight adults: A randomised controlled trial
PubMed ID: 38306892
Four weeks of mycoprotein substitution modestly lowered total cholesterol in overweight hypercholesterolemic adults.
- Evaluating the Effects of Corn Flour Product Consumption on Cardiometabolic Outcomes and the Gut Microbiota in Adults with Elevated Cholesterol: A Randomized Crossover
PubMed ID: 38880174
Adding corn bran to refined corn flour produced a modest LDL reduction in adults with elevated LDL.
- Similar changes in diet quality indices, but not nutrients, among African American participants randomized to follow one of the three dietary patterns of the US Dietary Guidelines: A secondary analysis
PubMed ID: 39366028
Randomized diet trial where vegetarian arm raised fiber intake and small BP reductions were linked to plant‑based diet scores—supports cardiovascular risk factor improvement attributable in part to higher fiber intake.
- A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial
PubMed ID: 39843443
Legume‑rich (high‑fiber) diet produced clinically meaningful LDL and total cholesterol reductions.
- Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study
PubMed ID: 40057729
High‑fiber, improved‑fat diet (MoKaRi) produced substantial LDL reductions, a major heart‑health benefit.
- Does the provision of free medically tailored groceries high in fibre or healthy fats impact sodium and potassium intakes? Secondary data analysis of a randomised controlled trial with extended follow-up
PubMed ID: 41351703
Randomized provision of high‑fiber groceries to post‑cardiac patients reduced sodium and raised potassium during the intervention—directly relevant to cardiac risk.
- Effects of defatted rice bran-fortified bread on gut microbiome, cardiovascular risk, gut discomfort, wellbeing and gut physiology in healthy adults with low dietary fibre intake
PubMed ID: 40127766
Defatted rice‑bran‑fortified bread doubled fiber intake and increased HDL / improved TC:HDL ratio.
- Supplementing the standard diet with brown rice bran powder might effectively improve the metabolic syndrome characteristics and antioxidant status: an open label randomized controlled trial
PubMed ID: 39775811
Brown rice bran RCT reduced LDL cholesterol and improved metabolic markers in metabolic syndrome patients.
- Fibre-Enriched High-Carbohydrate (FEHC) Diet Modulates Inflammation Without Affecting Bone Health in Older Women With Obesity: A Randomised Clinical Trial
PubMed ID: 41026958
High‑fiber, high‑carb diet in older women with obesity reduced systemic inflammatory markers (IL‑6, IL‑8, TNFα) relevant to heart risk.
- Comparison of Low-Gluten Diets Rich in Oats or Rice-A 6-Week Randomized Clinical Trial With Metabolically Challenged Volunteers
PubMed ID: 40331457
Oat‑rich diet produced significant LDL and total cholesterol reductions—direct cardiovascular risk benefit.
- Development and empirical evaluation of a dietary intervention programme for individuals with prediabetes based on the health action process approach: A randomised controlled trial
PubMed ID: 41421300
Prediabetes program raising fibre‑rich foods improved BMI and glucose, indirectly supporting heart health.
- Agrarian diet improves metabolic health in HIV-positive men with Prevotella-rich microbiomes: results from a randomized trial
PubMed ID: 41294355
Short agrarian (high‑fibre) diet lowered LDL‑C (especially in certain microbiome backgrounds) and reduced some inflammatory markers.
- An oat-containing hypocaloric diet reduces systolic blood pressure and improves lipid profile beyond effects of weight loss in men and women
PubMed ID: 11340101
Oat-containing diet (soluble fibre source) produced significant reductions in systolic BP and total/LDL cholesterol, directly supporting cardiovascular benefit.
- Long-term effects of water-soluble dietary fiber in the management of hypercholesterolemia in healthy men and women
PubMed ID: 9024732
6‑month RCT: sustained modest reductions in total/LDL cholesterol with 15 g/day viscous soluble fiber.
- Effect of Gum Arabic (Acacia Senegal) supplementation on visceral adiposity index (VAI) and blood pressure in patients with type 2 diabetes mellitus as indicators of cardiovascular disease (CVD): a randomized and placebo-controlled clinical trial
PubMed ID: 29558953
Gum arabic in T2D raised HDL, lowered SBP and reduced visceral adiposity indexes—multiple cardiometabolic improvements supporting heart health.
- A dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnormalities by modifying faecal microbiota in people with type 2 diabetes
PubMed ID: 30266575
High‑fiber, polyphenol diet significantly lowered LDL and CRP—supports cardiovascular risk reduction though intervention combined.
- Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
PubMed ID: 35300378
Konjac reduced triglycerides/HbA1c and improved metabolic profile, supporting cardiometabolic health.
- Can guava fruit intake decrease blood pressure and blood lipids?
PubMed ID: 8383769
Guava intervention markedly raised soluble fiber and produced clinically meaningful BP reductions (~7–8 mmHg) and modest lipid improvements — strong direct cardiovascular benefit from increased soluble fiber.
- Influence of lifestyle modification on atherosclerotic progression determined by ultrasonographic change in the common carotid intima-media thickness
PubMed ID: 9094885
Observational: higher insoluble fiber intake inversely associated with carotid IMT progression (direct CV marker).
- Dietary protein and soluble fiber reduce ambulatory blood pressure in treated hypertensives
PubMed ID: 11641293
Randomized trial: 12 g/day soluble fiber (psyllium) lowered 24-h systolic BP ~6 mmHg in treated hypertensives—direct cardiovascular risk benefit.
- Intake of vegetables rich in carotenoids and risk of coronary heart disease in men: The Physicians' Health Study
PubMed ID: 11171873
Large prospective cohort: higher vegetable (fiber-containing) intake associated with ~23% lower CHD risk (observational, not fiber-specific).
- Is intake of breakfast cereals related to total and cause-specific mortality in men?
PubMed ID: 12600848
Large cohort: whole-grain cereal intake (fiber-rich) linked with ~15–20% lower total and CVD mortality (strong observational support for heart-health benefit).
- Associations between dietary patterns and arterial stiffness, carotid artery intima-media thickness and atherosclerosis
PubMed ID: 20431391
Prospective cohort associated low-fiber dietary patterns with modestly greater arterial stiffness years later (observational evidence linking fiber-poor diets to vascular risk).
- Effects of a healthy Nordic diet on cardiovascular risk factors in hypercholesterolaemic subjects: a randomized controlled trial (NORDIET)
PubMed ID: 20964740
A Nordic diet rich in plant foods/fiber produced clinically meaningful reductions in LDL cholesterol and systolic BP in a randomized trial.
- Low dose chromium-polynicotinate or policosanol is effective in hypercholesterolemic children only in combination with glucomannan
PubMed ID: 23453352
Glucomannan (fiber) combined with chromium reduced total and LDL cholesterol ≈15% in hypercholesterolemic children—relevant to heart risk factors.
- Brown and golden flaxseed reduce intestinal permeability and endotoxemia, and improve the lipid profile in perimenopausal overweight women
PubMed ID: 35311432
Flaxseed lowered LDL in a randomized trial, supporting a heart‑health benefit from a fiber-rich seed intervention.
- Metabolomics-Based Biomarker for Dietary Fat and Associations with Chronic Disease Risk in Postmenopausal Women
PubMed ID: 37245660
Large prospective analysis showed that associations between fat intake and CHD were markedly attenuated when accounting for dietary fiber, implying fiber is important for CHD risk modification.
- Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial
PubMed ID: 18460483
Ground flaxseed modestly lowered LDL and Lp(a) and improved insulin resistance—cardio-metabolic benefits.
- Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patients
PubMed ID: 22470031
Inulin/FOS/ALA-enriched cookies improved total/LDL cholesterol and CRP in obese men over 1 month.
- Potent antihypertensive action of dietary flaxseed in hypertensive patients
PubMed ID: 24126178
Large RCT: milled flaxseed produced clinically meaningful blood pressure reductions in PAD patients — strong CVD-relevant benefit.
- Walnuts and Vegetable Oils Containing Oleic Acid Differentially Affect the Gut Microbiota and Associations with Cardiovascular Risk Factors: Follow-up of a Randomized, Controlled, Feeding Trial in Adults at Risk for Cardiovascular Disease
PubMed ID: 31848609
Walnut diet changed gut microbiota with correlations to improved blood pressure and lipids — shows diet-fiber components can affect CVD markers.
- Diabetes Therapeutics of Prebiotic Soluble Dietary Fibre and Antioxidant Anthocyanin Supplement in Patients with Type 2 Diabetes: Randomised Placebo-Controlled Clinical Trial
PubMed ID: 40218856
60‑day supplement with inulin/rice bran (fiber) + anthocyanins lowered LDL‑C (~13%) in T2DM (randomized DBPC).
- Hypocholesterolaemic effects of lupin protein and pea protein/fibre combinations in moderately hypercholesterolaemic individuals
PubMed ID: 22032303
Large randomized trial: bars with plant protein + soluble fiber (oat or pectin) modestly but significantly lowered total cholesterol.
- Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial
PubMed ID: 15383514
Mediterranean‑style diet (higher fiber among other changes) produced clinically meaningful improvements in inflammation, endothelial function and insulin sensitivity—supports cardiovascular health though fiber not isolated.
- Avocado Fruit on Postprandial Markers of Cardio-Metabolic Risk: A Randomized Controlled Dose Response Trial in Overweight and Obese Men and Women
PubMed ID: 30213052
Replacing carbohydrates with avocado lowered postprandial glucose/insulin and improved endothelial function (FMD); avocado includes fiber plus MUFA.
- Alternative Foods in Cardio-Healthy Dietary Models That Improve Postprandial Lipemia and Insulinemia in Obese People
PubMed ID: 34209561
A fiber‑rich dietary pattern (fruit/avocado/whole grains) reduced postprandial TG/VLDL and improved insulin resistance—cardiometabolic support.
- Effects of Increasing Total Fruit Intake With Avocado and Mango on Endothelial Function and Cardiometabolic Risk Factors in Adults With Prediabetes
PubMed ID: 41698896
Adding avocado+mango improved FMD in people with prediabetes—vascular benefit plausibly supported by increased fiber and fruit.
- Cholesterol-lowering effect of barley bran flour and oil
PubMed ID: 8270757
Barley bran on a cholesterol‑lowering diet reduced total and LDL cholesterol in hypercholesterolemic subjects.
- The effects of concentrated barley beta-glucan on blood lipids in a population of hypercholesterolaemic men and women
PubMed ID: 17445284
Placebo-controlled RCT: concentrated barley β-glucan produced clinically meaningful LDL-C and total cholesterol reductions.
- Combining functional features of whole-grain barley and legumes for dietary reduction of cardiometabolic risk: a randomised cross-over intervention in mature women
PubMed ID: 24063257
Barley + legume diet reduced total and LDL cholesterol and apoB and lowered estimated Framingham risk in overweight women.
- High-Molecular-Weight β-Glucan Decreases Serum Cholesterol Differentially Based on the CYP7A1 rs3808607 Polymorphism in Mildly Hypercholesterolemic Adults
PubMed ID: 26936139
3 g/day high‑MW barley β‑glucan produced a small but significant total‑cholesterol reduction in mildly hypercholesterolemic adults.
- Barley β-glucan reduces blood cholesterol levels via interrupting bile acid metabolism
PubMed ID: 29115200
HMW β‑glucan lowered total cholesterol and increased bile acid synthesis—a plausible heart‑health mechanism.
- Barley β-glucan increases fecal bile acid excretion and short chain fatty acid levels in mildly hypercholesterolemic individuals
PubMed ID: 29872803
HMW β‑glucan increased fecal bile acid loss and colonic fermentation—mechanistic support for cholesterol lowering.
- Alterations in gut microbiota composition and metabolic parameters after dietary intervention with barley beta glucans in patients with high risk for metabolic syndrome development
PubMed ID: 30396006
4‑week barley β‑glucan bread modestly lowered plasma cholesterol and changed fecal SCFA—supports cardiovascular risk reduction.
- Nutritional and health benefits of a partial substitution of red and processed meat with non-soy legumes: a 6-week randomized controlled trial in healthy working-age men
PubMed ID: 40828321
Replacing red/processed meat with legumes increased fiber and reduced LDL/total cholesterol in a randomized trial.
- Effect of antioxidant-rich foods on plasma ascorbic acid, cardiac enzyme, and lipid peroxide levels in patients hospitalized with acute myocardial infarction
PubMed ID: 7797808
Antioxidant‑rich higher‑fiber diet in MI patients reduced oxidative markers and limited enzyme rise (multi‑component diet trial).
- Intake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study
PubMed ID: 8941095
Large prospective cohort found higher total dietary fiber associated with substantially lower coronary death — strong observational support.
- Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial
PubMed ID: 11829698
Mediterranean‑type, fiber‑rich diet lowered LDL and fasting insulin in hypercholesterolemic men (randomized dietary trial).
- Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds
PubMed ID: 25326876
Portfolio diet including viscous fiber lowered LDL ≈13% in RCT—clear heart benefit.
- The hypocholesterolemic effects of beta-glucan in oatmeal and oat bran. A dose-controlled study
PubMed ID: 2005733
Oat β‑glucan produced dose‑dependent LDL reductions (up to ~16%), strong CVD risk implication.
- Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial
PubMed ID: 11976156
FDA‑serving soluble fibers reduced cholesterol and estimated 10‑yr CVD risk in crossover trial.
- Cholesterol-lowering benefits of oat-containing cereal in Hispanic americans
PubMed ID: 15942550
Daily oat cereal with 3 g β‑glucan modestly lowered total and LDL cholesterol.
- Effect of an oat bran-rich supplement on the metabolic profile of overweight premenopausal women
PubMed ID: 15942159
Oat‑bran muffins raised HDL and improved total/HDL ratio in overweight women.
- Beta-glucan incorporated into a fruit drink effectively lowers serum LDL-cholesterol concentrations
PubMed ID: 16522906
5 g β‑glucan fruit drink lowered LDL/total cholesterol and altered absorption markers.
- Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure
PubMed ID: 17151592
β‑glucan foods improved post‑meal insulin and reduced BP in an obese subgroup—cardio benefit signal.
- Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial
PubMed ID: 17386092
Concentrated oat beta‑glucan lowered LDL and total cholesterol in 6 weeks—direct heart‑health relevant outcome.
- Simultaneous intake of beta-glucan and plant stanol esters affects lipid metabolism in slightly hypercholesterolemic subjects
PubMed ID: 17311944
Also provides mechanistic bile‑acid data (reduced absorption/increased synthesis) relevant to lipid lowering.
- The consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes
PubMed ID: 19230737
3 g/day beta‑glucan in T2D lowered LDL substantially (15.8%) and improved insulin resistance—cardio/metabolic benefits.
- Physicochemical properties of oat β-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial
PubMed ID: 20660224
Large RCT: 3 g/day high‑MW β‑glucan produced modest but significant LDL reductions (~4–6%), directly supporting heart health.
- Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians
PubMed ID: 22118569
Large dataset across ethnicities showing modest LDL reductions (4–10%) with bioactive oat β‑glucan when viscosity is adequate.
- The effects of beta-glucan rich oat bread on serum nitric oxide and vascular endothelial function in patients with hypercholesterolemia
PubMed ID: 25025057
Replacing wheat with oat‑bran bread increased serum NO and brachial artery diameters—acute vascular support though FMD unchanged.
- A randomized Placebo-Controlled Clinical Trial to Evaluate the Medium-Term Effects of Oat Fibers on Human Health: The Beta-Glucan Effects on Lipid Profile, Glycemia and inTestinal Health (BELT) Study
PubMed ID: 32138344
Daily 3 g oat β‑glucan produced substantial LDL and total‑cholesterol lowering over 8 weeks.
- Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial
PubMed ID: 34375514
Shiitake bars lowered triglycerides (~10%), a cardiometabolic benefit (β‑glucan containing food).
- Metabolite Biomarkers Linking a High-Fiber Rye Intervention with Cardiometabolic Risk Factors: The RyeWeight Study
PubMed ID: 40838659
High‑fiber rye produced greater weight/fat loss and lower CRP versus refined wheat, supporting cardiovascular risk reduction.
- A diet high in fatty fish, bilberries and wholegrain products improves markers of endothelial function and inflammation in individuals with impaired glucose metabolism in a randomised controlled trial: the Sysdimet study
PubMed ID: 21870174
Diet including wholegrain products (source of fiber) reduced some endothelial/inflammatory markers in people with impaired glucose metabolism—moderate cardiometabolic relevance.
- Beneficial changes in total cholesterol, LDL-C, biomarkers of intestinal inflammation, and vitamin E status in adults with metabolic syndrome consuming almonds as snack foods: a randomized controlled clinical trial
PubMed ID: 40409246
Almond snack trial (fiber‑containing food) lowered total and LDL cholesterol in metabolic‑syndrome participants.
- Preventive effects of diets supplemented with sweetie fruits in hypercholesterolemic patients suffering from coronary artery disease
PubMed ID: 15193907
Adding sweetie fruits (fiber-containing) lowered TC, LDL and TG in post-CABG hypercholesterolaemic patients.
- The formation of short-chain fatty acids is positively associated with the blood lipid-lowering effect of lupin kernel fiber in moderately hypercholesterolemic adults
PubMed ID: 24572041
Lupin kernel fiber lowered total and LDL cholesterol in hypercholesterolaemic adults (randomized crossover).
- Effects of whole-grain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome
PubMed ID: 26706023
Whole‑grain cereal raised propionate and was associated with lower postprandial insulin—favorable cardiometabolic signal.
- Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake
PubMed ID: 32075887
Mediterranean pattern with more fiber lowered total/LDL cholesterol and shifted microbiome toward fibre-degraders—direct heart‑health benefit.
- A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial
PubMed ID: 33388204
Plant-forward diet lowered zonulin and diastolic BP while increasing fibre-fermenters—supports cardiovascular/vascular health mechanisms.
- Short-chain fatty acids are key mediators of the favorable effects of the Mediterranean diet on intestinal barrier integrity: data from the randomized controlled LIBRE trial
PubMed ID: 36055959
Mediterranean diet increased SCFAs and improved gut barrier markers—plausible systemic benefit for heart health.
- Increases in Circulating and Fecal Butyrate are Associated With Reduced Blood Pressure and Hypertension: Results From the SPIRIT Trial
PubMed ID: 35730613
Longitudinal increases in butyrate were associated with modest reductions in systolic and diastolic BP—cardiovascular risk benefit linked to fibre-related metabolites.
- Effects of Wholegrain Compared to Refined Grain Intake on Cardiometabolic Risk Markers, Gut Microbiota, and Gastrointestinal Symptoms in Children: A Randomized Crossover Trial
PubMed ID: 37898434
Replacing refined grain with wholegrain oats/rye lowered LDL and triglycerides in children (direct lipid benefit).
- Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity
PubMed ID: 40669445
Chicory root raised butyrate and reduced triglycerides and improved insulin sensitivity—favourable cardiometabolic effects.
- [Influence of physical therapy on intestinal microbiota, blood pressure control and systemic inflammation level: a randomized controlled study of 84 patients with arterial hypertension]
PubMed ID: 40421856
Fiber‑enriched diet arms increased fecal SCFAs, lowered endotoxin/inflammation and improved BP/arterial stiffness in hypertensive patients (cardiovascular risk improvements).
- An Indian experiment with nutritional modulation in acute myocardial infarction
PubMed ID: 1550016
Post‑MI dietary intervention that increased soluble fiber (among other changes) produced substantial improvements in lipids and weight.
- Reduced serum cholesterol with dietary change using fat-modified and oat bran supplemented diets
PubMed ID: 2154513
Oat‑bran (soluble fiber) intervention produced clinically meaningful reductions in total cholesterol (~10–17%), supporting cardiovascular benefit.
- [The use of highly purified glucomannan-based fibers in childhood obesity]
PubMed ID: 1324483
Glucomannan study in obese children reported reductions in triglycerides and cholesterol (nonrandomized), suggesting cardiometabolic support.
- Nutrient intake and blood pressure in the Dietary Intervention Study in Children
PubMed ID: 9095079
Observational cohort in children showed higher fiber intake associated with modestly lower systolic/diastolic blood pressure — relevant to heart health.
- The PREMIER intervention helps participants follow the Dietary Approaches to Stop Hypertension dietary pattern and the current Dietary Reference Intakes recommendations
PubMed ID: 17761231
DASH‑style lifestyle intervention (promoting fiber‑rich foods) produced meaningful diet quality changes linked to cardiovascular risk reduction.
- Characteristics of the diet patterns tested in the optimal macronutrient intake trial to prevent heart disease (OmniHeart): options for a heart-healthy diet
PubMed ID: 18237574
DASH‑like controlled feeding lowered blood pressure and LDL; fiber was held constant but diet patterns that emphasize fiber are cardioprotective.
- DASH lowers blood pressure in obese hypertensives beyond potassium, magnesium and fibre
PubMed ID: 19626043
Fruits/vegetables DASH lowered BP and improved vascular function; fiber was a component though not sole driver.
- A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins, and plasma total homocysteine in hypercholesterolemic subjects
PubMed ID: 12081819
Large RCT: soy protein product that included cotyledon fiber reduced LDL cholesterol and homocysteine in hypercholesterolemic adults—cardiovascular risk markers improved.
- Chia seed (Salvia hispanica L.) supplementation to the diet of adults with type 2 diabetes improved systolic blood pressure: A randomized controlled trial
PubMed ID: 33530854
Chia (40 g/day) reduced systolic blood pressure in adults with T2DM — direct BP benefit relevant to heart health.
- The diet and moderate exercise trial (DAMET): results after 24 weeks
PubMed ID: 1290315
Large RCT with a fruit/veg (fiber‑rich) diet + exercise lowered total and LDL cholesterol (cardio benefit, but confounded by exercise).
- Plasma F(2)-isoprostanes Are Positively Associated with Glycemic Load, but Inversely Associated with Dietary Polyunsaturated Fatty Acids and Insoluble Fiber in Postmenopausal Women
PubMed ID: 28747487
Cross-sectional: higher insoluble fiber associated with lower oxidative‑stress marker, a cardiovascular risk correlate (observational evidence).
- Metabolomic profiling of a cholesterol lowering plant-based diet from two randomized controlled feeding trials
PubMed ID: 40263496
Portfolio (plant-based, viscous-fiber–containing) diet RCT produced metabolomic changes consistent with cardioprotective effects; effect attributable to whole diet including viscous fiber.
- Effects of isomaltodextrin in postprandial lipid kinetics: Rat study and human randomized crossover study
PubMed ID: 29715296
Isomaltodextrin reduced postprandial TG Cmax in a higher‑risk human subgroup — relevant to cardiometabolic risk.
- Improved Plasma Lipids, Anti-Inflammatory Activity, and Microbiome Shifts in Overweight Participants: Two Clinical Studies on Oral Supplementation with Algal Sulfated Polysaccharide
PubMed ID: 36005503
SXRG84 reduced inflammation and non-HDL cholesterol in overweight subgroups, relevant to cardiovascular risk.
- Fiber-multivitamin combination therapy: a beneficial influence on low-density lipoprotein and homocysteine
PubMed ID: 12200762
Soluble-fiber + B-vitamin combination produced clinically meaningful LDL and ApoB reductions—direct heart-health–relevant lipid benefit.
- Is dietary fiber beneficial in chronic ischemic heart disease?
PubMed ID: 11198784
Fenugreek/guar/wheat fiber supplement modestly lowered LDL and increased Apo A‑1 in ischemic heart disease patients → moderate support.
- Synergistic effects of psyllium in the dietary treatment of hypercholesterolemia
PubMed ID: 2218650
Psyllium (~20 g/day) added to diet produced further clinically meaningful LDL/total cholesterol reductions.
- Cholesterol-lowering effects of soluble-fiber cereals as part of a prudent diet for patients with mild to moderate hypercholesterolemia
PubMed ID: 2173390
Psyllium‑enriched cereal modestly lowered total and LDL cholesterol in hypercholesterolaemic men (randomized trial).
- The effect of foods containing refined Konjac meal on human lipid metabolism
PubMed ID: 2158794
Konjac (glucomannan) foods lowered triglycerides and total cholesterol markedly in hyperlipidemic elderly—strong lipid benefit relevant to cardiovascular risk.
- Randomized, controlled, crossover trial of oat bran in hypercholesterolemic subjects
PubMed ID: 1660530
Randomized crossover in hypercholesterolemic subjects: oat bran lowered total and LDL cholesterol vs wheat/diet alone—supports heart health.
- Dietary strategies for risk-factor modification to prevent cardiovascular diseases
PubMed ID: 1666320
Heart‑healthy dietary intervention including more fiber reduced risk factors and cardiovascular events (multifactorial effect; fiber is one component).
- Do beans and oat bran add to the effectiveness of a low-fat diet?
PubMed ID: 1327742
Oat bran/beans improved HDL and LDL/HDL ratio though total/LDL not significantly lower—mixed but supportive for heart health.
- Influence of two guar preparations on glycosylated hemoglobin, total cholesterol and triglycerides in patients with diabetes mellitus
PubMed ID: 1335441
Guar fibre preparations in diabetics significantly reduced HbA1 and total cholesterol over 12 weeks.
- Wheat-bran and oat-bran supplements' effects on blood lipids and lipoproteins
PubMed ID: 1315121
Controlled diet study: oat bran produced significant reductions in total and LDL cholesterol vs wheat bran.
- Lathosterol and other noncholesterol sterols during treatment of hypercholesterolemia with lovastatin alone and with cholestyramine or guar gum
PubMed ID: 1319735
Adding guar gum to lovastatin produced greater cholesterol lowering than lovastatin alone (adjunct benefit).
- Cholesterol-lowering effects of psyllium-enriched cereal as an adjunct to a prudent diet in the treatment of mild to moderate hypercholesterolemia
PubMed ID: 1319110
Psyllium‑enriched cereal lowered total and LDL cholesterol versus wheat bran in hypercholesterolemic subjects.
- Dietary modulators of lipid metabolism in the Indian diet-heart study (I.D.H.S.)
PubMed ID: 1316885
Randomized diet trial with increased dietary fiber (and fatty-acid profile changes) significantly reduced total and LDL cholesterol and triglycerides.
- Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of one year follow up
PubMed ID: 1586782
Post-MI cardioprotective diet including soluble fiber produced greater lipid lowering, marked weight loss and far fewer cardiac events — strong clinical benefit though multifactorial.
- Effects on serum lipids of adding fruits and vegetables to prudent diet in the Indian Experiment of Infarct Survival (IEIS)
PubMed ID: 1511475
Addition of fruits/vegetables (rich in soluble fiber) after MI lowered cholesterol and triglycerides (dietary package effect).
- Effect of oatbran on mild hyperlipidaemia
PubMed ID: 1331724
60 g/day oatbran lowered LDL and LDL/HDL ratio in hyperlipidaemic subjects (randomized crossover).
- Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol
PubMed ID: 8389421
Very high soluble‑fiber diets modestly lowered total and LDL cholesterol and greatly increased bile‑acid loss—mechanism for heart benefit.
- Dietary fiber and coronary heart disease in middle-aged hypercholesterolemic men
PubMed ID: 8398218
Large prospective study found modest inverse association between dietary fiber and CHD risk—supports population-level heart benefit.
- Effects of diet and lifestyle changes on atherosclerotic risk factors after 24 weeks on the Indian Diet Heart Study
PubMed ID: 8498367
Large lifestyle program including more soluble fiber produced ~13–17% reductions in total and LDL cholesterol (multifactorial intervention, fiber likely contributory).
- Diet, lipids and cardiovascular disease in women
PubMed ID: 8409106
AHA/high-fiber diets across trials produced consistent 8–18% reductions in total/LDL cholesterol (dietary pattern evidence implicates fiber as an active component).
- Psyllium reduces blood lipids in men and women with hyperlipidemia
PubMed ID: 8160720
Psyllium (~6.7 g/day) produced modest but significant reductions in total and LDL cholesterol in hypercholesterolaemic subjects.
- The cholesterol-lowering effect of a breakfast cereal containing psyllium fibre
PubMed ID: 7830631
Daily psyllium breakfast cereal produced small but consistent reductions in total and LDL cholesterol in men with mild hypercholesterolaemia.
- Long-term treatment of hypercholesterolemia with dietary fiber
PubMed ID: 7985708
About 20 g/day mixed fibres over ~9–12 months produced modest sustained reductions in total and LDL cholesterol.
- Long-term comparison of three dietary prescriptions in the treatment of NIDDM
PubMed ID: 8112194
Long (18-month) diet trial including high-fibre option showed sustained reductions in LDL cholesterol, a cardiovascular risk factor.
- Lipid profiles after the daily consumption of an oat-based cereal: a controlled crossover trial
PubMed ID: 8279405
Oat‑based (soluble) fiber cereal produced small but significant reductions in total and LDL cholesterol in a crossover trial (moderate effect size).
- Soluble fiber enhances the hypocholesterolemic effect of the step I diet in childhood
PubMed ID: 8586774
Psyllium reduced total and LDL cholesterol in children — direct evidence supporting heart-health aspects of soluble fiber.
- [Evaluation of the action of glucomannan on metabolic parameters and on the sensation of satiation in overweight and obese patients]
PubMed ID: 7796558
Glucomannan added to a low-calorie diet produced better weight, blood‑glucose and cholesterol outcomes than diet alone.
- Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men
PubMed ID: 7872224
Konjac (glucomannan) lowered total cholesterol (−10%) and LDL (−7.2%) in a randomized crossover trial—clear cardiometabolic benefit.
- von Willebrand factor, a possible indicator of endothelial cell damage, decreases during long-term compliance with a lipid-lowering diet
PubMed ID: 7782727
3‑year lipid‑lowering dietary intervention that included increased fiber intake reduced total and LDL cholesterol and vWF—supports heart health though multiple diet changes were involved.
- Effect of psyllium in hypercholesterolemia at two monounsaturated fatty acid intakes
PubMed ID: 9129487
Psyllium produced consistent and clinically meaningful LDL and total-cholesterol reductions — strong heart-health evidence.
- Effects of lowering fat and increasing dietary fiber on fasting and postprandial plasma lipids in hypercholesterolemic subjects consuming a mixed Mediterranean-Western diet
PubMed ID: 9394698
Adding substantial dietary fiber to a low‑fat diet produced clinically meaningful reductions in total and LDL cholesterol—strong evidence for heart health support.
- Long-term effect of soluble-fiber foods on postprandial fat metabolism in dyslipidemic subjects with apo E3 and apo E4 genotypes
PubMed ID: 9280177
Soluble-fiber foods lowered fasting total cholesterol and increased bile-acid output—direct cardiometabolic benefit.
- Intestinal fatty acid-binding protein variation associated with variation in the response of plasma lipoproteins to dietary fibre
PubMed ID: 9373766
Genotype-stratified crossover study: soluble-fiber diet produced larger decreases in total/LDL cholesterol in certain carriers—supports heart-related benefit.
- Lipid- and glucose-lowering efficacy of Plantago Psyllium in type II diabetes
PubMed ID: 9747644
Psyllium (5 g TID) in T2D lowered fasting glucose and improved lipid profile (LDL, TG, HDL) in an RCT—supports cardiovascular risk improvement.
- Full-fat rice bran and oat bran similarly reduce hypercholesterolemia in humans
PubMed ID: 9566995
Oat bran and full‑fat rice bran lowered serum cholesterol vs placebo in a randomized trial—dietary bran (fiber) effect on lipids.
- Ispaghula husk in the treatment of hypercholesterolaemia: a double-blind controlled study
PubMed ID: 10201553
Large RCT: ispaghula (psyllium) produced clinically meaningful LDL and total cholesterol reductions—direct heart‑health mechanism.
- Long-term effects of consuming foods containing psyllium seed husk on serum lipids in subjects with hypercholesterolemia
PubMed ID: 9497178
24-week psyllium RCT produced modest LDL lowering (≈5.3%) — supports cardiovascular risk reduction.
- The effect of a low-fat, high-carbohydrate diet on serum high density lipoprotein cholesterol and triglyceride
PubMed ID: 9805219
Dietary switch to low‑sat‑fat, high‑carbohydrate, fibre‑rich diet substantially lowered total and LDL cholesterol (~14% and ~18%) — supports heart health though multi‑component diet.
- Cookies enriched with psyllium or oat bran lower plasma LDL cholesterol in normal and hypercholesterolemic men from Northern Mexico
PubMed ID: 9853540
8-week feeding trial with psyllium/oat bran produced large LDL reductions (−22.6% and −26%) — strong evidence for heart‑health effects.
- Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia
PubMed ID: 10500014
Psyllium reduced total and LDL cholesterol in men with T2D; supports heart-health biomarkers.
- Cholesterol lowering with high-viscosity hydroxypropylmethylcellulose
PubMed ID: 10569330
Large RCT: HPMC (soluble fiber-like) dose-dependently lowered LDL/total cholesterol — clear heart-risk biomarker benefit.
- Long-term blood cholesterol-lowering effects of a dietary fiber supplement
PubMed ID: 10429748
Randomized placebo-controlled trial: mixed-fiber supplement (20 g/d) produced sustained LDL reductions over months—strong lipid-mediated heart-health support.
- Consumption of oat milk for 5 weeks lowers serum cholesterol and LDL cholesterol in free-living men with moderate hypercholesterolemia
PubMed ID: 10749030
Oat (beta‑glucan) milk reduced total and LDL cholesterol ~6%—direct evidence supporting heart health.
- A study to assess the effect of dietary supplementation with soluble fibre (Minolest) on lipid levels in normal subjects with hypercholesterolaemia
PubMed ID: 10497668
Soluble fiber (guar/psyllium product) modestly lowered total and LDL cholesterol in an RCT over 3 months.
- The Finnish Diabetes Prevention Study
PubMed ID: 10889804
Lifestyle program including increased fiber and exercise produced weight and cardiovascular risk marker improvements (multicomponent intervention).
- High-molecular-weight hydroxypropylmethylcellulose taken with or between meals is hypocholesterolemic in adult men
PubMed ID: 10867040
High‑molecular‑weight HPMC (viscous fiber) significantly lowered total and LDL cholesterol in a randomized trial — strong direct support for cardiovascular risk factor improvement.
- Rye bread decreases serum total and LDL cholesterol in men with moderately elevated serum cholesterol
PubMed ID: 10720164
Rye-bread (fiber-rich) intervention lowered total and LDL cholesterol in men, consistent with cardiovascular benefit.
- Sex and hormonal status influence plasma lipid responses to psyllium
PubMed ID: 11566640
Psyllium 15 g/day modestly lowered LDL (−7 to −9%) and altered lipoprotein-related activity (CETP).
- High-soluble-fiber foods in conjunction with a telephone-based, personalized behavior change support service result in favorable changes in lipids and lifestyles after 7 weeks
PubMed ID: 11985406
High‑soluble‑fiber foods plus coaching reduced total and LDL cholesterol and triglycerides, beneficial for heart health.
- High-fiber oat cereal compared with wheat cereal consumption favorably alters LDL-cholesterol subclass and particle numbers in middle-aged and older men
PubMed ID: 12145006
High‑fiber oat cereal (soluble fiber) improved LDL subfractions and LDL:HDL ratio, supporting heart health.
- Soy in hypercholesterolaemia: a double-blind, placebo-controlled trial
PubMed ID: 11965512
Soy supplement including soy fiber modestly lowered total and LDL cholesterol versus placebo.
- Dietary counselling for dyslipidemia in primary care: results of a randomized trial
PubMed ID: 12493139
Psyllium-containing cereal produced small but meaningful LDL and cholesterol-ratio improvements over 6 months.
- Dietary patterns and nutrient intakes of 7-year-old children taking part in an atherosclerosis prevention project in Finland
PubMed ID: 11985408
Long-term dietary counseling from infancy increased fibre intake and was associated with healthier nutrient patterns and lower cholesterol, supporting heart health.
- Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control?
PubMed ID: 11978259
Whole-grain oat cereal trial reduced total and LDL cholesterol and allowed BP med reduction — strong evidence for heart-health benefits of oat fibre.
- The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity
PubMed ID: 14633807
Intensive lifestyle including higher fiber produced better glucose and lipid measures—heart-health relevant though multi-factorial.
- Carob pulp preparation rich in insoluble fibre lowers total and LDL cholesterol in hypercholesterolemic patients
PubMed ID: 14569404
Randomized RCT: carob (insoluble) fiber produced a moderate, statistically significant LDL reduction (~10.5%), supporting heart-health effects.
- Short-term effects of an intensive lifestyle modification program on lipid peroxidation and antioxidant systems in patients with coronary artery disease
PubMed ID: 14724371
Intensive lifestyle program including a high-fiber diet increased antioxidant markers in coronary artery disease patients (supportive but multi-component intervention).
- Effect of soluble fiber intake in lipid and glucose levels in healthy subjects: a randomized clinical trial
PubMed ID: 15163472
Soluble fiber reduced LDL (~13%) and fasting glucose, supporting cardiovascular risk reduction.
- Supplementation of wheat fibre can improve risk profile in patients with dysmetabolic cardiovascular syndrome
PubMed ID: 15187818
Wheat fiber powder improved BP, glucose tolerance and lipids in metabolic-risk patients (direct cardiometabolic benefits).
- A double-blind placebo-controlled clinical trial compares the cholesterol-lowering effects of two different soy protein preparations in hypercholesterolemic subjects
PubMed ID: 15309422
Soy supplement with added soy fibre/phospholipids reduced total and LDL cholesterol more than soy protein alone—supports heart risk reduction.
- Direct comparison of dietary portfolio vs statin on C-reactive protein
PubMed ID: 15900306
Multi-component diet containing viscous fibers reduced CRP substantially (inflammation marker relevant to heart health), but effects not isolated to fiber.
- Dietary fiber intake and risk factors for cardiovascular disease in French adults
PubMed ID: 16332650
Large cross-sectional cohort: higher dietary fiber (especially cereal/insoluble) associated with lower BMI, BP, cholesterol and other CVD risk markers.
- Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants
PubMed ID: 15699225
Portfolio diet including viscous fiber produced large LDL reductions nearly comparable to a statin (multi-component trial).
- Psyllium decreased serum glucose and glycosylated hemoglobin significantly in diabetic outpatients
PubMed ID: 16154305
Psyllium husk improved HDL and reduced LDL/HDL ratio in T2D patients—beneficial lipid and cardiometabolic effects attributable to the fiber intervention.
- Effects of agar (kanten) diet on obese patients with impaired glucose tolerance and type 2 diabetes
PubMed ID: 15642074
Agar supplementation reduced total cholesterol modestly in obese/IGT or T2DM patients.
- Effect of combining psyllium fiber with simvastatin in lowering cholesterol
PubMed ID: 15911730
Psyllium (15 g/d) added to simvastatin gave modest additional LDL and apoB lowering (cardiovascular risk markers).
- Lupin kernel fibre-enriched foods beneficially modify serum lipids in men
PubMed ID: 15508014
Lupin kernel fibre (17–30 g/d) produced significant reductions in total and LDL cholesterol.
- Effect of dietary supplementation with glucomannan on plasma total cholesterol and low density lipoprotein cholesterol in hypercholesterolemic children
PubMed ID: 15955465
Glucomannan added to diet in hypercholesterolemic children produced substantial LDL/total cholesterol reductions, supporting heart-health effects.
- Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial
PubMed ID: 16585662
Lifestyle programs including DASH/high-fiber diets produced modest reductions in hypertension risk (multicomponent intervention).
- Dietary supplementation with chickpeas for at least 5 weeks results in small but significant reductions in serum total and low-density lipoprotein cholesterols in adult women and men
PubMed ID: 17191025
Chickpea (legume/fiber) feeding slightly but significantly lowered total and LDL cholesterol.
- Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study
PubMed ID: 17098085
Large lifestyle program that increased fiber intake produced substantial long-term reduction in diabetes risk and cardiometabolic benefits (multifactorial).
- A combination therapy including psyllium and plant sterols lowers LDL cholesterol by modifying lipoprotein metabolism in hypercholesterolemic individuals
PubMed ID: 16988115
Psyllium-containing cookies lowered LDL and total cholesterol, though sterol co-intervention confounds attribution.
- Effect of combining viscous fibre with lovastatin on serum lipids in normal human subjects
PubMed ID: 17935545
Psyllium (with lovastatin) produced substantial additional LDL/TC reductions; psyllium alone had modest lipid effects.
- Effectiveness of a lifestyle intervention on metabolic syndrome. A randomized controlled trial
PubMed ID: 17922167
Lifestyle program that increased fiber reduced metabolic syndrome, central obesity and triglycerides—cardio-metabolic benefits.
- Long-term effects of a plant-based dietary portfolio of cholesterol-lowering foods on blood pressure
PubMed ID: 17457340
Portfolio diet including viscous fiber lowered BP modestly and produced small weight loss in uncontrolled intervention.
- Hydroxypropylmethylcellulose significantly lowers blood cholesterol in mildly hypercholesterolemic human subjects
PubMed ID: 17882138
Randomized trials: viscous HPMC fiber produced clinically meaningful LDL and total cholesterol reductions.
- Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber on plasma low-density lipoprotein cholesterol and other clinical markers of cardiovascular risk
PubMed ID: 17161227
Konjac-mannan (soluble fiber) added to diet produced substantial LDL reductions in randomized trial.
- Effect of a high-fiber diet vs a fiber-supplemented diet on C-reactive protein level
PubMed ID: 17353499
Raising fiber (DASH or supplement) reduced CRP (inflammation marker) which is relevant to cardiovascular risk.
- Different effect of psyllium and guar dietary supplementation on blood pressure control in hypertensive overweight patients: a six-month, randomized clinical trial
PubMed ID: 17729055
Psyllium (3.5 g t.i.d.) lowered systolic/diastolic blood pressure and triglycerides in overweight hypertensive patients—direct cardiovascular risk factor benefits.
- Randomised study to compare the efficacy and safety of isapgol plus atorvastatin versus atorvastatin alone in subjects with hypercholesterolaemia
PubMed ID: 17824470
Ispaghula (psyllium) added to atorvastatin produced greater LDL‑C lowering vs statin alone—supports cardiovascular risk reduction.
- Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial
PubMed ID: 18031592
Soluble-fiber supplement significantly lowered LDL cholesterol in overweight/obese adults, a key heart‑health marker.
- Comparison of a dietary portfolio diet of cholesterol-lowering foods and a statin on LDL particle size phenotype in hypercholesterolaemic participants
PubMed ID: 17663803
A diet portfolio including soluble fiber produced substantial LDL reductions comparable to a statin, supporting cardiovascular benefit.
- Effects of grape antioxidant dietary fiber in cardiovascular disease risk factors
PubMed ID: 18485668
Grape-derived fiber+antioxidant supplement produced clinically meaningful LDL/total cholesterol and BP reductions, supporting heart health.
- Chickpeas may influence fatty acid and fiber intake in an ad libitum diet, leading to small improvements in serum lipid profile and glycemic control
PubMed ID: 18502235
Chickpea addition raised fiber intake and produced modest reductions in total and LDL cholesterol—direct heart‑health–relevant changes.
- Efficacy of lifestyle changes in modifying practical markers of wellness and aging
PubMed ID: 18383987
Multi‑component lifestyle including added fiber improved TC:HDL ratio and reduced weight—supports cardiovascular risk improvement (fiber not sole driver).
- Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women
PubMed ID: 18328014
Daily flaxseed (a fiber‑containing food) reduced total and LDL cholesterol by ~7% and ~10% in postmenopausal women — supports cardiovascular risk reduction.
- Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines
PubMed ID: 18416823
Raisin intake (fiber‑rich fruit) lowered LDL and some inflammation markers in adults — plausible heart‑health benefit from a fiber‑rich component of the diet.
- The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome
PubMed ID: 18175740
Whole‑grain replacement during calorie restriction reduced abdominal fat and CRP — improvements relevant to cardiovascular risk and metabolic health.
- Reduction in risk factors for type 2 diabetes mellitus in response to a low-sugar, high-fiber dietary intervention in overweight Latino adolescents
PubMed ID: 19349560
Increased fiber (and reduced sugar) lowered insulin response and visceral fat in teens — metabolically favorable for heart health.
- Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial
PubMed ID: 19196472
Viscous fiber (PGX) yielded modest reductions in total and LDL cholesterol in healthy volunteers.
- Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk
PubMed ID: 19289389
Higher dietary fiber intake in older adults associated with lower blood pressure and improved lipid/glycemic markers in a large intervention.
- Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study
PubMed ID: 19130041
Lifestyle increases in natural fiber intake were independently associated with reductions in CRP and trends in IL-6—lower inflammation can support heart health.
- Effects of lupin kernel flour-enriched bread on blood pressure: a controlled intervention study
PubMed ID: 19144734
Replacing bread with high-protein/high-fiber lupin bread lowered systolic blood pressure and pulse pressure in overweight/obese adults, supporting cardiovascular risk reduction.
- Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors: a 12-month randomized controlled weight loss trial
PubMed ID: 20938438
Lupin-enriched (high-protein/high-fiber) foods improved insulin measures and modestly lowered ambulatory BP — supports some heart-health effects.
- NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
PubMed ID: 21164548
NUTRIOSE RCT reduced insulin resistance and improved lipid profile (HDL up, LDL/total/TG down) — direct support for heart health.
- A high legume low glycemic index diet improves serum lipid profiles in men
PubMed ID: 20734238
Controlled legume-rich, high-fermentable-fibre diet reduced total cholesterol, LDL and triglycerides in men.
- Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods
PubMed ID: 20102847
Oat β‑glucan as part of diet during weight loss lowered LDL/total cholesterol and non‑HDL—supports heart health via lipid improvement.
- The relation of low glycaemic index fruit consumption to glycaemic control and risk factors for coronary heart disease in type 2 diabetes
PubMed ID: 20978741
Increased low‑GI fruit (higher fiber) associated with improved HDL and systolic BP in T2DM cohort—observational but relevant to CV risk.
- Insoluble carob fiber rich in polyphenols lowers total and LDL cholesterol in hypercholesterolemic sujects
PubMed ID: 20094802
Double‑blind RCT: carob fiber (insoluble, polyphenol‑rich) produced large reductions in total and LDL cholesterol—strong CV risk‑factor evidence.
- The beneficial effects of α-cyclodextrin on blood lipids and weight loss in healthy humans
PubMed ID: 21127475
α‑Cyclodextrin produced small but significant reductions in total and LDL cholesterol in overweight adults.
- Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial
PubMed ID: 20413122
Psyllium 14 g/d reduced LDL, triglycerides and systolic BP in hypercholesterolaemic adults—direct cardio benefit.
- A pilot comprehensive lifestyle intervention program (CLIP)--comparison with qualitative lifestyle advice and simvastatin on cardiovascular risk factors in overweight hypercholesterolaemic individuals
PubMed ID: 20110160
Structured lifestyle/functional-foods program (high-fiber among components) produced greater short-term LDL and waist improvements vs advice.
- [Randomized clinical trial with a inulin enriched cookie on risk cardiovascular factor in obese patients]
PubMed ID: 20204256
Inulin 3 g/day modestly lowered total and LDL cholesterol in obese subjects after 1 month.
- Effects of lifestyle modification on oxidized LDL, reactive oxygen species production and endothelial cell viability in patients with coronary artery disease
PubMed ID: 20416290
Lifestyle program including high-fiber diet improved lipids and oxidative markers in CAD patients (multicomponent intervention—fiber contribution plausible but not isolated).
- Comparison of high protein and high fiber weight-loss diets in women with risk factors for the metabolic syndrome: a randomized trial
PubMed ID: 21524314
High‑fiber wholegrain/legume diet improved metabolic markers compared with baseline—supports cardiovascular risk reduction.
- Randomized controlled trial to improve adiposity, inflammation, and insulin resistance in obese African-American and Latino youth
PubMed ID: 21293446
16‑week program raising fiber (and reducing sugar) improved insulin sensitivity and reduced hepatic fat/inflammatory markers—cardiometabolic benefits.
- Effect of a dietary portfolio of cholesterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia: a randomized controlled trial
PubMed ID: 21862744
6‑month RCT portfolio diet including viscous fibre produced substantial LDL reductions, supporting cardiovascular benefit (multi‑component diet).
- Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults
PubMed ID: 21414045
HVP soluble fiber reduced certain cholesterol measures in overweight women—direct cardiometabolic benefit.
- Eating buckwheat cookies is associated with the reduction in serum levels of myeloperoxidase and cholesterol: a double blind crossover study in day-care centre staffs
PubMed ID: 21931228
Buckwheat (fiber‑containing food) trial associated with lower total cholesterol; food‑based evidence, modest effect.
- Randomized controlled trial of oatmeal consumption versus noodle consumption on blood lipids of urban Chinese adults with hypercholesterolemia
PubMed ID: 22866937
Daily instant oatmeal (soluble fiber) lowered total and LDL cholesterol and reduced waist circumference—direct heart‑health benefit.
- Effect of legumes as part of a low glycemic index diet on glycemic control and cardiovascular risk factors in type 2 diabetes mellitus: a randomized controlled trial
PubMed ID: 23089999
Adding legumes (low‑GI, high‑fiber) improved HbA1c and reduced estimated CHD risk and systolic BP—clear cardiovascular benefit.
- Cocoa, hazelnuts, sterols and soluble fiber cream reduces lipids and inflammation biomarkers in hypertensive patients: a randomized controlled trial
PubMed ID: 22383996
Multi‑ingredient cocoa cream including soluble fiber lowered LDL and some inflammation markers, but effects are confounded by other ingredients.
- Chitin-glucan fiber effects on oxidized low-density lipoprotein: a randomized controlled trial
PubMed ID: 22948945
Randomized trial: chitin-glucan (4.5 g/d) significantly lowered oxidized LDL—a relevant cardiometabolic marker supporting heart health.
- Persimmon fruit tannin-rich fiber reduces cholesterol levels in humans
PubMed ID: 23171573
Persimmon‑derived tannin‑rich fiber lowered total and LDL cholesterol in adults with mild hypercholesterolemia.
- Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial
PubMed ID: 22848584
Psyllium (6 g/d) in adolescents lowered LDL and improved fat distribution, both relevant to cardiovascular risk.
- Improvement effect of resistant maltodextrin in humans with metabolic syndrome by continuous administration
PubMed ID: 23419401
Resistant maltodextrin (9 g/day) lowered triglycerides and visceral fat in metabolic‑syndrome patients—markers relevant to cardiometabolic risk.
- Intakes of dietary fiber, vegetables, and fruits and incidence of cardiovascular disease in Japanese patients with type 2 diabetes
PubMed ID: 24170762
Large prospective cohort: higher dietary fiber (esp. soluble) strongly associated with much lower stroke risk in T2D patients.
- Soy fiber improves weight loss and lipid profile in overweight and obese adults: a randomized controlled trial
PubMed ID: 23881774
Soy‑fiber biscuits lowered LDL cholesterol in overweight adults, supporting heart‑health benefit.
- A high-fibre bean-rich diet versus a low-carbohydrate diet for obesity
PubMed ID: 23627924
Bean‑rich high‑fiber diet reduced LDL and total cholesterol vs low‑carb, supporting heart‑health effects of fiber.
- Regular consumption of a cocoa product improves the cardiometabolic profile in healthy and moderately hypercholesterolaemic adults
PubMed ID: 23823716
Fibre-rich cocoa product increased HDL and lowered glucose/inflammatory markers in humans — moderate direct cardiovascular support (but confounded by other components).
- A CHO/fibre diet reduces and a MUFA diet increases postprandial lipaemia in type 2 diabetes: no supplementary effects of low-volume physical training
PubMed ID: 24132660
Isoenergetic diet higher in carbohydrate + fiber lowered postprandial triglyceride-rich lipoproteins in T2D — direct cardiometabolic benefit relevant to heart health.
- Lifestyle intervention reduces body weight and improves cardiometabolic risk factors in worksites
PubMed ID: 23426035
Multicomponent program including high-fiber diet produced substantial weight loss and improved cardiometabolic markers (cholesterol/glucose) though effects are multi-factorial.
- Changes in visceral adiposity and serum cholesterol with a novel viscous polysaccharide in Japanese adults with abdominal obesity
PubMed ID: 23512917
PGX (viscous fiber) reduced total/LDL cholesterol and abdominal fat, both relevant to cardiovascular risk.
- Fiber intake and plasminogen activator inhibitor-1 in type 2 diabetes: Look AHEAD (Action for Health in Diabetes) trial findings at baseline and year 1
PubMed ID: 25131348
Higher habitual fiber intake associated with lower PAI-1 (cardiovascular risk marker) in a large lifestyle trial cohort (association).
- Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber
PubMed ID: 25646321
Whole-grain wheat (fiber-containing matrix) increased polyphenol metabolites and reduced TNF-α (anti-inflammatory, cardio-relevant).
- Intensive low-glycaemic-load dietary intervention for the management of glycaemia and serum lipids among women with gestational diabetes: a randomized control trial
PubMed ID: 25222105
Low‑glycaemic‑load (higher‑fiber) diet improved glucose and some lipid measures in gestational diabetes — supportive for cardiometabolic risk.
- Resistant starch type 4-enriched diet lowered blood cholesterols and improved body composition in a double blind controlled cross-over intervention
PubMed ID: 24478107
RS4-enriched flour substitution significantly lowered total and non‑HDL cholesterol in metabolic‑syndrome subgroup — strong heart‑health signal.
- Whole-grain intake favorably affects markers of systemic inflammation in obese children: a randomized controlled crossover clinical trial
PubMed ID: 24478050
Whole-grain (fiber-rich) intake lowered inflammatory markers in overweight girls—plausibly cardioprotective.
- Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity
PubMed ID: 24997634
Mediterranean-style diet (higher fiber) improved lipids and glucose in obese children (large, clinically relevant changes).
- A whole-grain cereal-based diet lowers postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome
PubMed ID: 24598599
Whole‑grain cereal diet lowered postprandial insulin and triglycerides in metabolic‑syndrome patients, supporting cardiometabolic benefits.
- Wine grape pomace flour improves blood pressure, fasting glucose and protein damage in humans: a randomized controlled trial
PubMed ID: 26337448
Grape pomace fiber (20 g/d) modestly lowered systolic BP — supports cardiovascular benefit signal.
- Influence of dietary fat and carbohydrates proportions on plasma lipids, glucose control and low-grade inflammation in patients with type 2 diabetes-The TOSCA.IT Study
PubMed ID: 26303195
Large observational study in T2D linked higher relative fiber intake to better lipids and lower inflammation—supports cardiovascular risk reduction.
- A multifunctional diet improves cardiometabolic-related biomarkers independently of weight changes: an 8-week randomized controlled intervention in healthy overweight and obese subjects
PubMed ID: 26370118
Multifunctional diet including viscous fibers produced large, weight‑independent improvements in total and LDL cholesterol (cardiometabolic benefit).
- Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial
PubMed ID: 26529006
Infant formula with fructans ± probiotic lowered triglycerides/LDL and raised HDL in that trial—lipid changes relate to heart health.
- Effects of total fibre or resistant starch-rich diets within lifestyle intervention in obese prediabetic adults
PubMed ID: 25588971
12‑month intervention: general high‑fiber diet improved 2‑h glycaemia and RS‑focused group showed lipid improvements—supports cardiovascular risk reduction.
- Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial
PubMed ID: 27919453
Tartary buckwheat (fiber‑rich whole food) modestly lowered insulin and total/LDL cholesterol in T2D over 4 weeks—direct cardiometabolic improvements (food has multiple bioactives).
- Sex differences in food choices, adherence to dietary recommendations and plasma lipid profile in type 2 diabetes - The TOSCA.IT study
PubMed ID: 27212622
Large observational study: adherence to dietary recommendations including higher fiber associated with lower LDL—supports heart‑health associations.
- Effects of oat bran and nutrition counseling on the lipid and glucose profile and anthropometric parameters of hypercholesterolemia patients
PubMed ID: 27019267
Oat bran 40 g/day in hypercholesterolemic adults lowered LDL and improved insulin‑resistance indices beyond counseling—relevant to heart health support.
- Cerebrovascular and cognitive benefits of high-oleic peanut consumption in healthy overweight middle-aged adults
PubMed ID: 27386745
High-oleic peanut intake (contains fiber among other components) improved small-artery elasticity and cerebrovascular responsiveness—cardiovascular benefit likely multifactorial.
- [Effect of simvastatin plus inulin in comparison with simvastatin plus ezetimibe on the treatment of mixed dyslipidemia]
PubMed ID: 27792720
Inulin (a fermentable fibre) added to simvastatin produced clinically meaningful lipid improvements, supporting cardiovascular risk reduction adjunctively.
- Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study
PubMed ID: 28376899
Oat soluble fiber (β‑glucan 3 g/day) significantly lowered total cholesterol and LDL — established heart‑health mechanism.
Digestive support (293)
- Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids: randomized controlled trial
PubMed ID: 10813126
Ispaghula husk as part of anorectal/hemorrhoid care improved bleeding cessation times and bowel outcomes — supports overall digestive health.
- A randomized, prospective, comparison study of a mixture of acacia fiber, psyllium fiber, and fructose vs polyethylene glycol 3350 with electrolytes for the treatment of chronic functional constipation in childhood
PubMed ID: 22677568
Pediatric fiber mix improved constipation symptoms, implying easier digestion/defecation in children with functional constipation.
- Effect of composite yogurt enriched with acacia fiber and Bifidobacterium lactis
PubMed ID: 22969230
Yogurt with acacia fiber + B. lactis improved IBS symptoms and bowel‑habit satisfaction vs control (combined product).
- Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial
PubMed ID: 38653808
RCT evidence that acacia fiber increases stool frequency and improves IBS‑related symptoms supports general digestive wellbeing.
- A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial
PubMed ID: 28870194
Dried yeast fermentate trial reported reduced bloating/fullness and symptom score improvements (prebiotic‑like benefit).
- Resistant Maltodextrin Consumption in a Double-Blind, Randomized, Crossover Clinical Trial Induces Specific Changes in Potentially Beneficial Gut Bacteria
PubMed ID: 35683992
Resistant maltodextrin produced specific increases in beneficial bacteria linked to digestive health.
- Gut Permeability Might be Improved by Dietary Fiber in Individuals with Nonalcoholic Fatty Liver Disease (NAFLD) Undergoing Weight Reduction
PubMed ID: 30453660
Large improvements in zonulin and liver/steatosis markers with increased fiber indicate improved overall digestive health and barrier function.
- Minor Changes in the Composition and Function of the Gut Microbiota During a 12-Week Whole Grain Wheat or Refined Wheat Intervention Correlate with Liver Fat in Overweight and Obese Adults
PubMed ID: 33188417
Whole‑grain wheat prevented liver fat increase and shifted microbiota toward more fermentative capacity—support for digestive wellbeing.
- Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
PubMed ID: 35300378
Konjac improved microbiota diversity, metabolic markers and likely GI symptoms — strong evidence for overall digestive wellbeing.
- Small volume isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in treatment of chronic nonorganic constipation
PubMed ID: 8769292
Marked improvements in bowel frequency, straining and transit point to better overall digestive wellbeing (strong GI evidence, though from PEG).
- Low-attenuation oral GI contrast agents in abdominal-pelvic computed tomography
PubMed ID: 16252139
Fiber-containing oral contrast altered colonic transit and luminal distention — direct evidence that fibre affects digestive transit characteristics.
- Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome
PubMed ID: 19909743
High‑quality imaging evidence that bran alters small‑bowel water and transit and documents differences in IBS patients — substantial physiological support for digestive benefits.
- Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs
PubMed ID: 28740352
Low‑FODMAP program led to substantial IBS symptom improvement and allowed supervised fiber reintroduction without symptom return — supports balanced digestion strategies.
- Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial
PubMed ID: 35971232
Prune juice RCT produced clear improvements in stool consistency and constipation symptoms — directly easing digestion.
- Use of Insoluble Dietary Fiber and Probiotics for Bowel Preparation Before Colonoscopy: A Prospective Study
PubMed ID: 35202009
Wheat‑bran + probiotic preload improved bowel clearance with less laxative — consistent with supporting a balanced preparatory digestive routine.
- Brown and golden flaxseed reduce intestinal permeability and endotoxemia, and improve the lipid profile in perimenopausal overweight women
PubMed ID: 35311432
Flaxseed improved gut permeability and endotoxemia, physiologic improvements that support overall digestive health.
- Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention
PubMed ID: 39864520
Inulin induced substantial, reproducible changes in gut microbiota and metabolome consistent with improved digestive ecosystem health and function.
- Effect of type of fiber, site of fermentation, and method of analysis on digestibility of soluble and insoluble fiber in rabbits
PubMed ID: 26115273
Well-quantified effects: higher soluble-fiber diets increased ileal TDF digestibility and changed where fiber is digested — strong mechanistic evidence for altered digestion.
- An Assessment of the Glyconutrient Ambrotose™ on Immunity, Gut Health, and Safety in Men and Women: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial
PubMed ID: 32545396
Ambrotose altered gut permeability and immune markers — evidence of improved gut balance in humans.
- The Impact of Glucomannan, Inulin, and Psyllium Supplementation (Soloways(TM)) on Weight Loss in Adults with FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 38398881
Comprehensive RCT of mixed soluble fibers produced clinically meaningful benefits in appetite, weight, and likely gut function — strong support for digestive wellbeing.
- Effect of arabinogalactan on the gut microbiome: A randomized, double-blind, placebo-controlled, crossover trial in healthy adults
PubMed ID: 34004416
Arabinogalactan produced robust microbiome and fecal metabolite changes in a randomized crossover — strong evidence for improving digestive ecology.
- A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke (Cynara scolymus) in healthy human subjects
PubMed ID: 20591206
Clear bifidogenic effect from inulin in healthy adults—microbial benefits that underpin overall digestive wellbeing.
- Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity
PubMed ID: 39033197
Large RCT in children showed increased beneficial taxa and diversity following inulin, consistent with improved digestive wellbeing.
- Avocado Consumption Alters Gastrointestinal Bacteria Abundance and Microbial Metabolite Concentrations among Adults with Overweight or Obesity: A Randomized Controlled Trial
PubMed ID: 32805028
Avocado intervention shifted gut microbiota and increased acetate in overweight/obese adults—favorable digestive milieu changes.
- Barley β-glucan increases fecal bile acid excretion and short chain fatty acid levels in mildly hypercholesterolemic individuals
PubMed ID: 29872803
Higher SCFA production and bile acid excretion indicate altered colonic fermentation and digestive balance.
- Alterations in gut microbiota composition and metabolic parameters after dietary intervention with barley beta glucans in patients with high risk for metabolic syndrome development
PubMed ID: 30396006
4‑week β‑glucan bread produced favorable SCFA and microbiota changes plus modest cholesterol lowering—broad digestive benefits.
- The effects of waxy barley on defecation, sleep, mental health, and quality of life: a randomized double-blind parallel-group comparison study
PubMed ID: 40336123
Consistent RCT evidence of improved stool frequency/amount and secondary sleep/mood benefits—strong overall digestive benefit in young women.
- Anti-Inflammatory Diet Prevents Subclinical Colonic Inflammation and Alters Metabolomic Profile of Ulcerative Colitis Patients in Clinical Remission
PubMed ID: 36014800
Anti‑inflammatory diet that increased fiber produced a substantially higher rate of subclinical colonic improvement (lower fecal calprotectin) in UC patients.
- Telephone counseling intervention increases intakes of micronutrient- and phytochemical-rich vegetables, fruit and fiber in breast cancer survivors
PubMed ID: 14747688
Large counseling trial increased fiber and produce intake; improved dietary patterns commonly linked to better gut comfort (indirect).
- Gastrointestinal tolerance and plasma status of carotenoids, EPA and DHA with a fiber-enriched tube feed in hospitalized patients initiated on tube nutrition: Randomized controlled trial
PubMed ID: 27126710
Marked reduction in diarrhea with fiber‑enriched tube feed—direct improvement in gut comfort.
- [Combination of early nasojejunal feeding with modern synbiotic therapy in the treatment of severe acute pancreatitis (prospective, randomized, double-blind study)]
PubMed ID: 16167471
Synbiotic reduced serious complications in pancreatitis and supports gut health (multi‑component data).
- Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial
PubMed ID: 17386092
Fermentability to SCFAs plus lipid benefits suggests multi‑modal contributions to digestive and metabolic wellbeing.
- Effects of legume kernel fibres and citrus fibre on putative risk factors for colorectal cancer: a randomised, double-blind, crossover human intervention trial
PubMed ID: 24060277
Blue lupin and citrus fibers increased fecal bulk, SCFA and improved transit — direct digestion benefits.
- The formation of short-chain fatty acids is positively associated with the blood lipid-lowering effect of lupin kernel fiber in moderately hypercholesterolemic adults
PubMed ID: 24572041
Lupin fiber improved SCFA and lipid markers; supports broader digestive and metabolic health.
- Pilot study of the feasibility and effectiveness of a natural laxative mixture
PubMed ID: 17430744
Laxative mixture normalized stool consistency and increased bowel movements, contributing to balanced digestion in elderly.
- Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project
PubMed ID: 39710576
Multifunctional cereal mix reduced intestinal inflammation (fecal calprotectin) and modified microbiota—likely improves gut comfort (fiber part of mix).
- Apparent fiber digestibility and fecal short-chain fatty acid concentrations with ingestion of two types of dietary fiber
PubMed ID: 8164297
Different fibers raised colonic SCFAs markedly, reflecting improved colonic fermentation and environment.
- Randomized clinical trial of Plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis. Spanish Group for the Study of Crohn's Disease and Ulcerative Colitis (GETECCU)
PubMed ID: 10022641
Psyllium increased fecal butyrate and had few GI adverse events in UC patients—suggests tolerated improvement in gut milieu.
- The effect of wheat bran particle size on laxation and colonic fermentation
PubMed ID: 12038477
Finely ground wheat bran increased fecal bulk and fermentation markers—promotes easier defecation.
- Lupin kernel fibre foods improve bowel function and beneficially modify some putative faecal risk factors for colon cancer in men
PubMed ID: 16469156
Lupin kernel fibre increased stool frequency/weight and sped gut transit in healthy men.
- Fecal butyrate levels vary widely among individuals but are usually increased by a diet high in resistant starch
PubMed ID: 21430242
Resistant starch generally increased fecal butyrate and total SCFA—beneficial fermentation products linked to colonic health.
- Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals
PubMed ID: 23977723
Butyrylated starch strongly increased fecal butyrate and beneficial bacteria in healthy adults—supports colonic wellbeing.
- Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults
PubMed ID: 28179226
Whole‑grain substitution produced modest but beneficial SCFA and microbiota changes relevant to digestive health.
- A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial
PubMed ID: 33388204
Plant-forward diet increased butyrate-producers and lowered zonulin—improved gut integrity and microbiota.
- Short-chain fatty acids are key mediators of the favorable effects of the Mediterranean diet on intestinal barrier integrity: data from the randomized controlled LIBRE trial
PubMed ID: 36055959
Mediterranean RCT increased SCFAs and improved barrier markers—high-quality evidence for digestive wellbeing.
- The impact of almonds and almond processing on gastrointestinal physiology, luminal microbiology, and gastrointestinal symptoms: a randomized controlled trial and mastication study
PubMed ID: 36130222
Modest increases in fecal butyrate and stool frequency suggest general digestive benefit for some individuals.
- Substitution of Refined Conventional Wheat Flour with Wheat High in Resistant Starch Modulates the Intestinal Microbiota and Fecal Metabolites in Healthy Adults: A Randomized, Controlled Trial
PubMed ID: 35102419
High-amylose wheat increased fecal butyrate and reduced proteolytic toxins—meaningful digestive benefit.
- The prebiotic effects of soluble dietary fiber mixture on renal anemia and the gut microbiota in end-stage renal disease patients on maintenance hemodialysis: a prospective, randomized, placebo-controlled study
PubMed ID: 36517799
Soluble-fiber mix produced increases in serum butyrate and beneficial taxa with clinical hematologic improvements—supports digestive and systemic wellbeing.
- Continuous partially hydrolyzed guar gum intake reduces cold-like symptoms: a randomized, placebo-controlled, double-blinded trial in healthy adults
PubMed ID: 35916813
PHGG increased fecal SCFAs and improved symptom-days—positive for digestive wellbeing.
- The Effects of High Fiber Rye, Compared to Refined Wheat, on Gut Microbiota Composition, Plasma Short Chain Fatty Acids, and Implications for Weight Loss and Metabolic Risk Factors (the RyeWeight Study)
PubMed ID: 35458231
High-fiber rye in weight-loss context gave modest plasma butyrate increases and reduced CRP—beneficial for gut/systemic health.
- A microbiome-targeting fibre-enriched nutritional formula is well tolerated and improves quality of life and haemoglobin A1c in type 2 diabetes: A double-blind, randomized, placebo-controlled trial
PubMed ID: 36594522
Microbiome‑targeting fiber improved butyrate‑producers and clinical measures in T2D—supports gut and systemic wellbeing.
- Impact of Combined Prebiotic Galacto-Oligosaccharides and Bifidobacterium breve-Derived Postbiotic on Gut Microbiota and HbA1c in Prediabetic Adults: A Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 39064648
Soluble‑fiber/prebiotic supplement improved glycaemia and reduced LBP (indicator of gut barrier integrity)—supportive of digestive wellbeing.
- A Symbiotic Meal Containing Extruded Sorghum and Probiotic (Bifidobacterium longum) Ameliorated Intestinal Health Markers in Individuals with Chronic Kidney Disease: A Secondary Analysis of a Subsample from a Previous Randomized and Controlled Clinical Trial
PubMed ID: 38931207
Symbiotic meal raised SCFAs and improved stool frequency and GI symptoms in dialysis patients (direct improvement in digestion/evacuation).
- Quality and quantity of carbohydrates, faecal short-chain fatty acids and gastrointestinal symptoms - results from a randomised, controlled trial (CARBFUNC)
PubMed ID: 39631208
Different fibre patterns substantially altered fecal SCFAs (functionally important), though symptoms were minimally changed.
- The anti-inflammatory effects of three different dietary supplement interventions
PubMed ID: 41094562
Synbiotic reduced systemic inflammatory proteins and increased serum butyrate—supports gut‑host health and digestive wellbeing.
- Short-chain fatty acid kinetics and concentrations are higher after inulin supplementation in young and older adults: a randomized trial
PubMed ID: 40274191
Inulin significantly increased SCFA production and fecal SCFAs in young and older adults—broadly beneficial for digestive health.
- [Influence of physical therapy on intestinal microbiota, blood pressure control and systemic inflammation level: a randomized controlled study of 84 patients with arterial hypertension]
PubMed ID: 40421856
Fiber‑enriched diets raised fecal SCFAs, reduced endotoxin and improved vascular/inflammatory markers in hypertensive patients (digestive and systemic benefit).
- The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
PubMed ID: 40947861
Butyrylated starch markedly increased fecal butyrate and lowered pH, altering colonic environment favorably despite no polyp count change.
- Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial
PubMed ID: 26255043
Dietary interventions (low‑FODMAP/traditional) both reduced IBS symptoms including measures of gut comfort; indirect relevance to fiber/fermentable carbs.
- Colorectal adenomas and diet: a case-control study of subjects participating in the Nottingham faecal occult blood screening programme
PubMed ID: 8381298
Large case‑control associating higher cereal fiber with substantially lower colorectal adenoma odds — supports long‑term digestive health relevance.
- Randomized, double-blinded, placebo-controlled study of effect of wheat bran fiber and calcium on fecal bile acids in patients with resected adenomatous colon polyps
PubMed ID: 8537982
9‑month high‑dose wheat bran markedly lowered fecal bile acids — a strong mechanistic effect implying improved colonic milieu and potential long‑term digestive benefit.
- The effect of daily fortified yogurt consumption on weight loss in adults with metabolic syndrome: A 10-week randomized controlled trial
PubMed ID: 29724529
Fortified yogurt containing prebiotic fiber (plus other ingredients) provided modest benefits for body composition and insulin resistance; some digestive/nutritional benefit context-specific.
- Longitudinal effect of 20-year infancy-onset dietary intervention on food consumption and nutrient intake: the randomized controlled STRIP study
PubMed ID: 30397257
Long-term dietary counseling starting in infancy produced sustained small increases in fiber intake, supporting long-term dietary/health benefits.
- Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis
PubMed ID: 29777234
Demonstrates meaningful interaction between microbiome and fiber-rich diets for weight/fat loss — strong evidence that fiber intake can affect host physiology via the gut.
- Nutritional quality of calorie restricted diets in the CALERIE™ 1 trial
PubMed ID: 35643360
Calorie-restriction counseling generated a marked increase in fiber intake and improved diet quality — robust evidence that increasing fiber supports broad digestive and nutritional wellbeing.
- [Effect of ear mushroom (Auricularia) on functional constipation]
PubMed ID: 15266131
Direct human RCT: high-fiber ear-mushroom improved multiple stool-related symptoms and bowel frequency in chronic constipation—broad digestive wellbeing benefit.
- Safety of a thickened extensive casein hydrolysate formula
PubMed ID: 26704966
Thickened eCHF improved stool consistency in infants with cow's milk allergy, reflecting improved gut comfort in that population.
- Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial
PubMed ID: 27492975
Direct randomized evidence that chicory inulin improved stool frequency and consistency in constipated adults — strong support for digestive wellbeing.
- Effect of chicory inulin-type fructan-containing snack bars on the human gut microbiota in low dietary fiber consumers in a randomized crossover trial
PubMed ID: 32320024
Clear bifidogenic effect of inulin-type fructans in low-fiber adults without GI symptom worsening — supports microbiome-related digestive health.
- [Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study]
PubMed ID: 29378102
Strong clinical improvements in stool frequency, form, abdominal symptoms and quality-of-life in IBS-C with an inulin-containing product (direct digestive wellbeing signal).
- Effects of Resistant Glucan Mixture on Bowel Movement in Female Volunteers
PubMed ID: 27117853
Clinical RCT in constipated women showing resistant glucan improves stool frequency/volume — strong evidence for improved digestive wellbeing.
- Supplementation of Caricol®-Gastro reduces chronic gastritis disease associated pain
PubMed ID: 29604620
Caricol®-Gastro reduced gastritis pain vs placebo — indicates improved upper‑GI wellbeing in a clinical population (product included fiber).
- Assessment of DNA damage and its modulation by dietary and genetic factors in smokers using the Comet assay: a biomarker model
PubMed ID: 16076733
Prebiotic bread decreased faecal-water genotoxicity and lowered lymphocyte DNA damage in smokers—evidence of improved gut environment and digestive health markers.
- Combinations of laxatives and green banana biomass on the treatment of functional constipation in children and adolescents: a randomized study
PubMed ID: 29309737
RCT in constipated children showed meaningful symptom and stool-form improvement.
- Effectiveness of Partially Hydrolyzed Guar Gum in Reducing Constipation in Long Term Care Facility Residents: A Randomized Single-Blinded Placebo-Controlled Trial
PubMed ID: 35297467
PHGG reduced laxative needs in chronic constipation, improving practical wellbeing.
- The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiber
PubMed ID: 20191257
Strong RCT evidence that added oat-bran fiber improved bowel function and reduced laxatives—clear positive effect on digestive wellbeing.
- Two apples a day modulate human:microbiome co-metabolic processing of polyphenols, tyrosine and tryptophan
PubMed ID: 32103319
Two apples/day altered many microbial metabolites, indicating improved gut microbial activity related to digestive wellbeing.
- A comparison of mebeverine with high-fibre dietary advice and mebeverine plus ispaghula in the treatment of irritable bowel syndrome: an open, prospectively randomised, parallel group study
PubMed ID: 2177997
High‑fibre advice and ispaghula improved IBS symptoms, including pain and bowel measures, in a large randomized trial.
- Lactulose in the treatment of symptomatic diverticular disease: a comparative study with high-fibre diet
PubMed ID: 2169839
High‑fibre diet improved abdominal pain and bowel symptoms in diverticular disease (randomized comparison).
- The value of prescribed 'high-fibre' diets for the treatment of the irritable bowel syndrome
PubMed ID: 1667298
Higher fiber intake (>30 g/d) in IBS cohort associated with better stool consistency and reduced constipation/urgency—practical evidence of easier bowel function/digestion.
- Effects of cereal and vegetable fiber feeding on potential risk factors for colon cancer
PubMed ID: 1339081
Well-controlled feeding study showed fibre type/dose increased stool weight, sped transit and lowered fecal pH and bile acids—clear digestive effects.
- A dietary fibre supplement in the treatment of mild hypertension. A randomized, double-blind, placebo-controlled trial
PubMed ID: 1313484
Fibre supplement RCT lowered BP, fasting insulin and weight—general health improvements that support digestive wellbeing.
- Efficacy of rifaximin on symptoms of uncomplicated diverticular disease of the colon. A pilot multicentre open trial. Diverticular Disease Study Group
PubMed ID: 1330083
Glucomannan produced substantial symptom improvement in diverticular disease—direct clinical evidence of improved gut comfort.
- Sex differences in colonic function: a randomised trial
PubMed ID: 8387940
Direct measures showed faster colonic transit and increased stool weight with fiber intake — objective improvement in digestion/colonic function.
- Chronic constipation in long stay elderly patients: a comparison of lactulose and a senna-fibre combination
PubMed ID: 8219947
Clear clinical improvements in stool frequency, consistency and ease of evacuation—strong benefit for digestive wellbeing.
- A comparison of Agiolax and lactulose in elderly patients with chronic constipation
PubMed ID: 8234437
Agiolax (fiber + senna) increased bowel frequency and eased evacuation vs lactulose in elderly constipated patients—clear digestive improvement.
- Encopresis: a study of treatment alternatives and historical and behavioral characteristics
PubMed ID: 8233146
High-fiber diet was central to encopresis treatment that produced long-term improvements in bowel behavior (programmatic evidence).
- Effect of dietary fiber (soy polysaccharide) on the severity, duration, and nutritional outcome of acute, watery diarrhea in children
PubMed ID: 8393174
In infants with watery diarrhoea, added soy fiber shortened duration of liquid stools from 163 to 43 h (~74% shorter) — strong direct digestive benefit.
- Reduction in diarrhea incidence by soluble fiber in patients receiving total or supplemental enteral nutrition
PubMed ID: 7602722
Clinical trial evidence that soluble fiber reduced diarrhea incidence in enterally‑fed patients — meaningful overall digestive benefit in that setting.
- Wheat fibre, lactulose and rectal mucosal proliferation in individuals with a family history of colorectal cancer
PubMed ID: 7827943
Twelve weeks of wheat fiber lowered rectal mucosal proliferation in high‑risk individuals — a favorable biomarker for long‑term digestive health.
- [Use of glucomannan dietary fiber in changes in intestinal habit]
PubMed ID: 8566676
Glucomannan RCT produced dose‑dependent increases in bowel movements without increasing diarrhea/flatulence—clear evidence of improved bowel function (easier digestion/evacuation).
- Diarrhea associated with nasogastric feedings
PubMed ID: 8628712
Enteral fiber reduced diarrhea incidence in men and affected GI discomfort patterns—direct evidence for improved gut comfort in some patients.
- Effect of fiber supplements on internal bleeding hemorrhoids
PubMed ID: 8975955
Psyllium supplementation reduced congested hemorrhoidal cushions and bleeding — clear symptomatic gut/anal comfort benefit.
- Lower serum oestrogen concentrations associated with faster intestinal transit
PubMed ID: 9252210
Wheat bran increased defecations and tended to speed transit and lowered oestrone sulphate — meaningful digestive effects.
- The effect of dietary fiber on bowel function following radical hysterectomy: a randomized trial
PubMed ID: 9299255
Clear improvements across multiple bowel outcomes after high‑fiber advice indicate a meaningful net gain in digestive wellbeing postoperatively.
- Use of soy fiber in acute diarrhea in infants and toddlers
PubMed ID: 9078414
Randomized trial in infants showed a large, clinically meaningful shortening of diarrhea duration with added soy fiber — strong evidence of improved gut comfort.
- Water supplementation enhances the effect of high-fiber diet on stool frequency and laxative consumption in adult patients with functional constipation
PubMed ID: 9684123
High‑fiber (25 g/day) improved constipation symptoms, increased stool frequency and reduced laxative use — likely improves gut comfort.
- Dietary fiber and plant foods in relation to colorectal cancer mortality: the Seven Countries Study
PubMed ID: 10188715
Large cohort: higher dietary fiber (~+10 g/day) associated with substantially lower long-term colorectal cancer mortality—strong observational support for long-term digestive health/wellbeing.
- Effects of pectin on diarrhea in critically ill tube-fed patients receiving antibiotics
PubMed ID: 11072556
Pectin added to tube feeds was associated with fewer diarrhea cases in antibiotic‑treated critically ill patients — improved gut comfort/tolerance.
- Treatment of recurrent abdominal pain: components analysis of four treatment protocols
PubMed ID: 10896070
Large symptom reductions in children with recurrent abdominal pain after fiber interventions indicate important overall digestive benefits.
- Effects of wheat bran and Olestra on objective measures of stool and subjective reports of GI symptoms
PubMed ID: 10811335
Wheat bran increased stool weight and water and slightly increased bowel movements, consistent with easier passage of stool.
- Long-term effect of fibre supplement and reduced energy intake on body weight and blood lipids in overweight subjects
PubMed ID: 11294130
Direct randomized fibre supplement trial showing clinically meaningful benefit (weight) and likely digestive improvements when used with dietary restriction; strong direct support among available trials.
- Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
PubMed ID: 11333990
Large lifestyle intervention (incl. more fibre) halved diabetes incidence and improved weight — strong evidence for overall digestive/metabolic wellbeing as part of multi-factor program.
- Randomized clinical trial of soy formula with and without added fiber in antibiotic-induced diarrhea
PubMed ID: 11598607
Soy-fibre–fortified formula halved antibiotic-associated diarrhea duration in children — very strong, direct evidence for improved gut comfort.
- Implementation of a 4-y, high-fiber, high-fruit-and-vegetable, low-fat dietary intervention: results of dietary changes in the Polyp Prevention Trial
PubMed ID: 11522565
Sustained increased fibre intake over 4 years with biomarker changes and modest weight effects — strong population-level support for improved digestive wellbeing.
- Supplementation with dietary fiber improves fecal incontinence
PubMed ID: 11480529
Psyllium/gum arabic improved stool form and reduced incontinence — clear improvement in digestive wellbeing.
- Gastrointestinal side effects of orlistat may be prevented by concomitant prescription of natural fibers (psyllium mucilloid)
PubMed ID: 11443512
Psyllium reduced orlistat-associated GI adverse events, reflecting improved GI comfort.
- Clinical studies in persistent diarrhea: dietary management with green banana or pectin in Bangladeshi children
PubMed ID: 11522739
Clear clinical improvement in infants with persistent diarrhoea after green banana or pectin (reduced stool output, faster recovery) — strong gut-comfort signal in this population.
- Early enteral supply of fiber and Lactobacilli versus conventional nutrition: a controlled trial in patients with major abdominal surgery
PubMed ID: 12093440
Enteral feeding with fibre + Lactobacillus reduced postoperative infections and improved clinical outcomes—indicates improved digestive/clinical wellbeing but effect is not fibre-only.
- Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients
PubMed ID: 12134110
Early enteral feeding including fibre + live Lactobacillus substantially reduced bacterial infections post-transplant—strong clinical digestive-wellbeing signal but confounded by probiotic use.
- High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial comparison between wheat bran diet and partially hydrolyzed guar gum (PHGG)
PubMed ID: 12184518
Direct RCT showing PHGG (soluble fiber) produced higher overall success and tolerability than bran for IBS—strong evidence for improved gut comfort.
- Rifaximin improves symptoms of acquired uncomplicated diverticular disease of the colon
PubMed ID: 12458383
Glucomannan produced symptomatic improvement in diverticular disease (higher asymptomatic rates with added rifaximin), indicating better gut comfort.
- [Influence of probiotics and fibre on the incidence of bacterial infections following major abdominal surgery - results of a prospective trial]
PubMed ID: 12436353
Enteral nutrition containing fibre and live Lactobacillus markedly lowered postoperative infections and improved tolerance—strong combined-evidence for improved clinical digestive outcomes in surgical patients.
- No harm from five year ingestion of oats in coeliac disease
PubMed ID: 11839710
Five-year oats intake produced no harm to gut mucosa or inflammation in coeliac adults—supports digestive wellbeing and tolerability.
- Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme
PubMed ID: 12737857
Observational finding that higher fiber intake associated with lower distal colorectal adenoma risk supports long‑term digestive health.
- Effects of fructo-oligosaccharide-supplemented infant cereal: a double-blind, randomized trial
PubMed ID: 13129464
FOS produced more frequent, softer stools without diarrhea in infants — evidence of balanced stooling.
- Fecal bile acid concentrations in a subpopulation of the wheat bran fiber colon polyp trial
PubMed ID: 12646507
Wheat‑bran produced long‑term fecal biochemical changes that may underlie improved digestive health.
- [Early jejunal nutrition with combined pre- and probiotics in acute pancreatitis--prospective, randomized, double-blind investigations]
PubMed ID: 12764986
Clinical benefit (reduced infected necrosis) when oat-fiber substrate used with probiotics in severe pancreatitis suggests important effects on digestive outcomes, though combined therapy limits attribution to fiber alone.
- The efficacy of cisapride vs. placebo and diet in patients with chronic constipation
PubMed ID: 12974147
Clinical data show substantial symptomatic improvement in constipation after a fiber-rich diet phase — strong support for overall digestive wellbeing.
- Probiotics, soluble fiber, and L-Glutamine (GLN) reduce nelfinavir (NFV)- or lopinavir/ritonavir (LPV/r)-related diarrhea
PubMed ID: 15768732
Soluble fiber + probiotics reduced stool frequency and watery stools in HIV-related diarrhea (improved comfort; multi-component).
- Effects of a high-fiber diet on symptoms of irritable bowel syndrome: a randomized clinical trial
PubMed ID: 15325678
IBS trial found symptom improvements with fiber (overall digestive symptom benefit from modest fiber).
- Paroxetine to treat irritable bowel syndrome not responding to high-fiber diet: a double-blind, placebo-controlled trial
PubMed ID: 15128360
High-fiber diet improved well-being and abdominal symptoms for a subset of IBS patients.
- Fiber (glucomannan) is beneficial in the treatment of childhood constipation
PubMed ID: 14993586
Glucomannan produced large, clinically meaningful improvements in constipation and GI symptoms in children (strong digestive-wellbeing evidence).
- The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans: a double-blind, randomized, placebo-controlled, parallel-group, dose-response relation study
PubMed ID: 15585783
Prebiotic fibers increased beneficial microbes and SCFA production—mechanistically supports balanced digestion.
- Fibre-supplemented tube feeding in the hospitalised elderly
PubMed ID: 15569656
Adding fibre to tube feeds reduced stool frequency and produced more formed stools—clear, clinically meaningful improvement in bowel function.
- Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis
PubMed ID: 15122774
Fermentable fiber in synbiotic altered microbiota and improved clinical measures in cirrhosis — indicates more balanced gut ecology/function (confounded).
- Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A multicenter randomized open trial
PubMed ID: 15986863
PHGG produced significant symptomatic and QoL improvements in IBS patients during treatment — strong evidence for digestive wellbeing while taken.
- Effects of flax fiber on laxation and glycemic response in healthy volunteers
PubMed ID: 16379563
Flax fiber increased fecal bulk (improves mechanical aspects of digestion/rectal transit).
- Partially hydrolysed guar gum supplemented comminuted chicken diet in persistent diarrhoea: a randomised controlled trial
PubMed ID: 15665181
Partially hydrolysed guar gum sped recovery and reduced stool output in children with persistent diarrhoea (clear digestive benefit).
- A controlled, randomized, double-blind trial to evaluate the effect of a supplement of cocoa husk that is rich in dietary fiber on colonic transit in constipated pediatric patients
PubMed ID: 16950955
Cocoa-husk fiber produced clinically meaningful improvements in transit and stool form in constipated children — strong support for digestive wellbeing in that population.
- A combination of fibre-rich rye bread and yoghurt containing Lactobacillus GG improves bowel function in women with self-reported constipation
PubMed ID: 16251881
Strong direct trial evidence that a fibre-rich rye diet improved transit, stool softness, frequency and eased defecation difficulty (overall digestive benefit).
- Decreased regurgitation with a soy formula containing added soy fiber
PubMed ID: 16429213
Adding soy fiber to infant formula meaningfully reduced regurgitation (improved GI comfort in infants).
- Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study
PubMed ID: 17761020
Whole-grain intake promoted beneficial microbiota changes, a key contributor to overall digestive wellbeing.
- Yoghurt containing galacto-oligosaccharides, prunes and linseed reduces the severity of mild constipation in elderly subjects
PubMed ID: 17299467
Yogurt with fibre-containing ingredients increased bowel movements and made defecation subjectively easier in elderly with mild constipation.
- Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients
PubMed ID: 17308252
Strong randomized trial evidence that synbiotic nutrition including fermentable fibers reduced intestinal permeability and dramatically lowered infections in trauma patients—major digestive wellbeing benefit in that population.
- Efficacy of long term cyclic administration of the poorly absorbed antibiotic Rifaximin in symptomatic, uncomplicated colonic diverticular disease
PubMed ID: 17226906
Dietary fiber alone improved symptoms of diverticular disease long-term, giving the strongest direct evidence among trials here for overall digestive wellbeing.
- Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective, randomized, double blind study
PubMed ID: 17523328
Synbiotic feeding reduced organ dysfunction/complications in severe pancreatitis, reflecting improved gut clinical outcomes (prebiotic fibers were part of the intervention).
- Comparison of early enteral nutrition in severe acute pancreatitis with prebiotic fiber supplementation versus standard enteral solution: a prospective randomized double-blind study
PubMed ID: 17569144
Randomized human trial with prebiotic fiber showed faster clinical recovery and reduced inflammatory markers in severe acute pancreatitis—strong evidence for improved digestive wellbeing in that context.
- A dietary fiber mixture versus lactulose in the treatment of childhood constipation: a double-blind randomized controlled trial
PubMed ID: 18979582
Fiber mixture performed comparably to lactulose for pediatric constipation—evidence for easing digestion in constipated children.
- Intervention with dietary fiber to treat constipation and reduce laxative use in residents of nursing homes
PubMed ID: 18382081
Practical clinical benefit (laxative cessation, maintained weight) indicates improved digestive wellbeing in elderly residents.
- [Effect of partially hidrolized guar-gum in the treatment of functional constipation among hospitalized patients]
PubMed ID: 18425236
High‑fiber hospital diet markedly reduced constipation and improved defecation frequency/consistency — strong evidence for improved digestive wellbeing in that setting.
- Phylotypes related to Ruminococcus bromii are abundant in the large bowel of humans and increase in response to a diet high in resistant starch
PubMed ID: 18616586
Resistant-starch-driven microbiota changes are mechanistically linked to a healthier colonic environment and wellbeing.
- [The effect of a fibre enriched dietary milk product in chronic primary idiopatic constipation]
PubMed ID: 18372941
Direct randomized evidence that soluble fiber substantially improved constipation symptoms and bowel function — strong support for digestive wellbeing.
- The effect of strict adherence to a high-fiber, high-fruit and -vegetable, and low-fat eating pattern on adenoma recurrence
PubMed ID: 19643809
Long‑term adherence to a high‑fiber, plant‑rich diet associated with reduced adenoma recurrence—supports digestive health over time.
- Fecal incontinence in obese women with urinary incontinence: prevalence and role of dietary fiber intake
PubMed ID: 19136088
Population data linking low fiber to fecal incontinence suggests fibre contributes to overall digestive health.
- A simple dietary message to improve dietary quality: Results from a pilot investigation
PubMed ID: 19359142
Pilot RCT: increasing fiber intake via a simple message improved diet quality and modestly reduced weight, consistent with broader digestive and health benefits.
- Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial
PubMed ID: 19713235
Psyllium produced clinically important symptom relief in IBS patients, improving gut comfort (pain/bloating/overall symptoms).
- Chickpea supplementation in an Australian diet affects food choice, satiety and bowel health
PubMed ID: 19945492
Chickpea supplementation improved perceived bowel function and satiety, indicating improved digestive wellbeing in free‑living adults.
- [Effectiveness of nutritional support for the liver-cell deficiency in the liver cirrhosis]
PubMed ID: 19552020
Nutritional supplement including specified fiber improved clinical signs and biochemical markers in cirrhosis—clinical digestive wellbeing improvements.
- Adopting a plant-based diet minimally increased food costs in WHEL Study
PubMed ID: 19296743
Large trial increased fiber intake substantially (+8.1 g/day) and broader dietary improvements—strongest population-level support for digestive wellbeing.
- [Efficacy of using inulin fortified fermented milk products in patients with functional constipation]
PubMed ID: 19663305
Inulin-fortified fermented milk improved constipation symptoms and patient-reported GI comfort—direct evidence of easer digestion in constipated patients.
- NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
PubMed ID: 21164548
NUTRIOSE RCT improved metabolic markers and body composition; resistant dextrin use often benefits bowel function and digestive wellbeing.
- Can partially hydrolyzed guar gum be an alternative to lactulose in treatment of childhood constipation?
PubMed ID: 21331988
PHGG in constipated children increased bowel movements and improved stool consistency — strong evidence for easier digestion/defecation.
- Mixed fibers diet in surgical ICU septic patients
PubMed ID: 21147705
Mixed‑fiber enteral diet reduced diarrhea score and improved global diarrhea measures—evidence of more balanced digestive function in ICU patients.
- Clinical trial: the combination of rifaximin with partially hydrolysed guar gum is more effective than rifaximin alone in eradicating small intestinal bacterial overgrowth
PubMed ID: 20937045
Soluble fiber markedly increased SIBO eradication rates when added to rifaximin — strong clinical signal for improved digestive health in that condition.
- [Effect of an original enteral feeding protocol on clinical outcome indicators in patients with acute cerebral damage of vascular and traumatic genesis]
PubMed ID: 20919542
Fiber‑containing enteral formula in ICU improved energy/nitrogen balance and reduced inflammatory/MOF signs—clinical digestive/physiologic benefit in patients.
- Linking long-term dietary patterns with gut microbial enterotypes
PubMed ID: 21885731
Strong human evidence linking long‑term high‑fiber diets to favorable microbiome enterotypes, transit, and SCFA—broad digestive benefits.
- Comparison of high protein and high fiber weight-loss diets in women with risk factors for the metabolic syndrome: a randomized trial
PubMed ID: 21524314
Human RCT increasing wholefood fiber produced metabolic improvements and increased fiber intake—supports overall digestive and metabolic wellbeing.
- Randomized controlled trial to improve adiposity, inflammation, and insulin resistance in obese African-American and Latino youth
PubMed ID: 21293446
16‑week nutrition program (reduce sugar/increase fiber) improved insulin sensitivity and hepatic fat—benefits relevant to digestive/metabolic wellbeing.
- Coarse, but not finely ground, dietary fibre increases intestinal Firmicutes:Bacteroidetes ratio and reduces diarrhoea induced by experimental infection in piglets
PubMed ID: 22018207
Wheat bran reduced diarrhoea in piglets and increased SCFA, supporting improved gut comfort in an animal model.
- Symptoms associated with dietary fiber supplementation over time in individuals with fecal incontinence
PubMed ID: 21543963
Large RCT measured GI symptoms with fibre supplements; shows measurable, symptom‑specific effects (some adverse such as fullness), so directly relevant to gut comfort.
- Perceptions of flatulence from bean consumption among adults in 3 feeding studies
PubMed ID: 22104320
Bean trials show initial gas increase then symptom decline for most people — indicates improved comfort with adaptation to fiber-rich legumes.
- Usefulness of psyllium in rehabilitation of obstructed defecation
PubMed ID: 21779973
Psyllium improved stool form and rectal sensitivity in ODS patients—likely improving gut comfort.
- Does a self-management program change dietary intake in adults with irritable bowel syndrome?
PubMed ID: 21455043
IBS self-management led to sustained increases in fiber and symptom management, consistent with better gut comfort.
- Weight loss improves fecal incontinence severity in overweight and obese women with urinary incontinence
PubMed ID: 21567259
Increased fiber intake associated with improved liquid fecal leakage—modest improvement to gut comfort.
- Randomised clinical trial: dried plums (prunes) vs. psyllium for constipation
PubMed ID: 21323688
Dried plums produced greater increases in bowel movements and improved stool consistency vs psyllium—clinically meaningful improvements in comfort for constipated patients.
- Efficacy of Lactobacillus paracasei sub. paracasei F19 on abdominal symptoms in patients with symptomatic uncomplicated diverticular disease: a pilot study
PubMed ID: 21372765
Clinically meaningful reductions in bloating and fewer long‑lasting pain episodes reported in patients on high‑fiber diet plus probiotic.
- [Influence of fiberform on defecation condition after surgery for benign anorectal lesion]
PubMed ID: 22205452
Fiber supplement (Fiberform) after anorectal surgery significantly eased defecation, reduced pain and improved stool consistency—directly eases digestion/evacuation.
- Effect of a mixture of inulin and fructo-oligosaccharide on Lactobacillus and Bifidobacterium intestinal microbiota of patients receiving radiotherapy: a randomised, double-blind, placebo-controlled trial
PubMed ID: 23588438
Prebiotic fiber accelerated return of beneficial gut bacteria after radiotherapy, supporting recovery of digestive wellbeing.
- Bowel function after minimally invasive urogynecologic surgery: a prospective randomized controlled trial
PubMed ID: 22453316
Postoperative bowel regimen including fiber wafers significantly shortened time to first bowel movement (direct evidence for facilitated bowel function).
- High-fibre diet and Lactobacillus paracasei B21060 in symptomatic uncomplicated diverticular disease
PubMed ID: 23139608
High‑fibre diet reduced abdominal pain and bloating in patients with uncomplicated diverticular disease, improving gut comfort.
- Digestive and physiologic effects of a wheat bran extract, arabino-xylan-oligosaccharide, in breakfast cereal
PubMed ID: 22771050
AXOS increased bifidobacteria and postprandial ferulic acid, indicating microbiota and antioxidant benefits for gut health.
- Randomised, double-blind and placebo-controlled study of the effect of a synbiotic dairy product on orocecal transit time in healthy adult women
PubMed ID: 23165580
Synbiotic product including fiber produced clinically meaningful reductions in orocecal transit time, especially in slow‑transit/constipated women.
- Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers: a double-blind, randomised, placebo-controlled, cross-over trial
PubMed ID: 22370444
Human RCT showed increased bifidobacteria, SCFA and reduced p‑cresol with wheat‑bran extract—strong evidence for digestive benefit.
- The effect of a sweet potato, footbath, and acupressure intervention in preventing constipation in hospitalized patients with acute coronary syndromes
PubMed ID: 22847287
Hospitalized cardiac patients receiving sweet potato as part of a multimodal program had less constipation and higher bowel satisfaction; digestion benefit likely but confounded.
- Impact of a resistant dextrin on intestinal ecology: how altering the digestive ecosystem with NUTRIOSE®, a soluble fibre with prebiotic properties, may be beneficial for health
PubMed ID: 22429361
Randomized controlled evidence that resistant dextrin favorably shifts gut microbiota and is well tolerated—strong support for digestive wellbeing.
- Intakes of dietary fiber, vegetables, and fruits and incidence of cardiovascular disease in Japanese patients with type 2 diabetes
PubMed ID: 24170762
Large cohort linking higher fiber intake with lower stroke risk in T2D supports long-term health tied to digestive patterns and diet quality.
- Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial
PubMed ID: 24332524
Prebiotic inulin improved glycemia, lowered LPS and inflammatory markers—broad benefits relevant to digestive wellbeing.
- In vitro degradation and fermentation of three dietary fiber sources by human colonic bacteria
PubMed ID: 23556460
Mechanistic in vitro fermentation data show how different fibers affect SCFA/gas production—important for digestive wellbeing depending on fiber chosen.
- Satiety and energy intake after single and repeated exposure to gel-forming dietary fiber: post-ingestive effects
PubMed ID: 24030518
Gelled pectin produced short‑term satiety and fermentation markers—supports some aspects of digestive wellbeing via fermentation.
- Polydextrose and soluble corn fiber increase five-day fecal wet weight in healthy men and women
PubMed ID: 23427334
Clear clinical evidence that soluble fibers (polydextrose, soluble corn fiber) increase fecal bulk, stool frequency and soften stool—strong impact on digestive wellbeing.
- Effect of microbiological and immunological enteral nutrition on intestinal function and immune status in the patients with long-term use of antibiotics
PubMed ID: 24089227
Combined enteral formula including fiber reduced abdominal pain/distension in patients on long‑term antibiotics—improved gut comfort reported.
- Daily consumption of a synbiotic yogurt decreases energy intake but does not improve gastrointestinal transit time: a double-blind, randomized, crossover study in healthy adults
PubMed ID: 23787118
Synbiotic with inulin improved energy intake and maintained higher fiber intake, supporting digestive health.
- Partially hydrolyzed guar gum in pediatric functional abdominal pain
PubMed ID: 23345946
PHGG significantly reduced IBS symptom severity and abdominal pain, directly improving gut comfort.
- Dietary fiber supplementation for fecal incontinence: a randomized clinical trial
PubMed ID: 25155992
Psyllium (≈15 g/day) halved fecal incontinence episodes and severity and altered stool gelling—strong, clinically meaningful GI comfort improvement.
- The effects of functional fiber on postprandial glycemia, energy intake, satiety, palatability and gastrointestinal wellbeing: a randomized crossover trial
PubMed ID: 25066659
Functional fibers reduced postprandial glycemia and subsequent intake—beneficial for GI/metabolic interplay contributing to wellbeing.
- Dietary fiber mixture in pediatric patients with controlled chronic constipation
PubMed ID: 24157445
Fiber mixture improved stool frequency and consistency in children — broad digestive wellbeing effects.
- Effects of dietary fiber with Bacillus coagulans lilac-01 on bowel movement and fecal properties of healthy volunteers with a tendency for constipation
PubMed ID: 25338680
Clear improvements in bowel function (frequency, form, incomplete evacuation) indicate benefits for overall digestive wellbeing in constipated subgroup.
- A multi-centre, randomised trial to assess whether increased dietary fibre intake (using a fibre supplement or high-fibre foods) produces healthy bowel performance and reduces laxative requirement in free living patients on peritoneal dialysis
PubMed ID: 24650128
Adding fiber (supplement/high‑fiber foods) in peritoneal dialysis patients improved bowel function and reduced laxative use in some.
- [Clinical benefits after soluble dietary fiber supplementation: a randomized clinical trial in adults with slow-transit constipation]
PubMed ID: 25623312
Pectin RCT improved transit, symptoms, and beneficial microbiota in constipated patients—strong evidence for digestive wellbeing.
- Effects of enteral nutritional support on malnourished patients with inflammatory bowel disease by subjective global assessment
PubMed ID: 25417609
Enteral/oral nutrition that increased fiber in IBD inpatients coincided with symptom improvements.
- Effect of increasing dietary fiber on plasma levels of colon-derived solutes in hemodialysis patients
PubMed ID: 25147155
Resistant starch reduced uremic toxins from gut microbes in dialysis patients, indicating improved gut‑derived metabolic burden.
- Effect of inulin and fructo-oligosaccharide on the prevention of acute radiation enteritis in patients with gynecological cancer and impact on quality-of-life: a randomized, double-blind, placebo-controlled trial
PubMed ID: 26603881
Prebiotic (inulin+FOS) RCT showed beneficial changes in stool consistency and trends toward QoL benefits—strongest direct digestive wellbeing evidence in the list.
- Loperamide Versus Psyllium Fiber for Treatment of Fecal Incontinence: The Fecal Incontinence Prescription (Rx) Management (FIRM) Randomized Clinical Trial
PubMed ID: 26347971
Psyllium reduced fecal incontinence and caused less constipation than loperamide, improving symptom burden and wellbeing.
- Digestion-resistant maltodextrin effects on colonic transit time and stool weight: a randomized controlled clinical study
PubMed ID: 26437831
Resistant maltodextrin produced clear improvements in transit, stool volume and consistency—strong overall digestive benefit.
- Psyllium fiber vs. placebo in early treatment after STARR for obstructed defecation: a randomized double-blind clinical trial
PubMed ID: 26325116
Psyllium post‑STARR reduced constipation and urgency up to 6 months, directly improving patient gut comfort.
- Effect of Polydextrose Intake on Constipation in Japanese Dialysis Patients: A Triple-Blind, Randomized, Controlled Trial
PubMed ID: 26440643
Polydextrose produced large improvements in stool frequency and bowel symptoms in constipated patients—strong digestive wellbeing evidence.
- Efficacy of partially hydrolyzed guar gum (PHGG) supplemented modified oral rehydration solution in the treatment of severely malnourished children with watery diarrhoea: a randomised double-blind controlled trial
PubMed ID: 26825757
PHGG added to ORS shortened diarrhoea duration and sped weight recovery in malnourished children—direct digestive benefit.
- Safety, growth, and support to healthy gut microbiota by an infant formula enriched with functional compounds
PubMed ID: 26718667
GOS increased beneficial bifidobacteria in infants—strong direct signal for improved digestive ecosystem and wellbeing.
- [Efficacy of pectin in the treatment of diarrhea predominant irritable bowel syndrome]
PubMed ID: 25809332
Pectin RCT in IBS‑D produced significant symptomatic improvements and better stool consistency—direct gut comfort benefit.
- [DIETARY SUPPLEMENT REKECEN IMPROVES SAFETY AND EFFICACY OF CHRONIC PROSTATITIS ANTIBACTERIAL THERAPY]
PubMed ID: 26094394
Fermented fiber+SCFA given with antibiotics markedly reduced antibiotic‑related GI adverse effects.
- Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial
PubMed ID: 26811130
Pea fiber improved glucose AUC and reduced energy intake/body fat; metabolic/stool effects suggest improved digestive balance.
- Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial)
PubMed ID: 27733151
Psyllium's clinical effects on glycaemia and expected stool effects indicate improved digestive balance.
- Randomized, double-blind, placebo-controlled trial of Ficus carica paste for the management of functional constipation
PubMed ID: 27440682
Fig paste RCT shortened colon transit time and improved stool consistency and abdominal symptoms in constipation.
- Psyllium Fiber Reduces Abdominal Pain in Children With Irritable Bowel Syndrome in a Randomized, Double-Blind Trial
PubMed ID: 27080737
Psyllium reduced abdominal pain frequency and constipated stools in children with IBS—clear benefit to overall digestive wellbeing in that population.
- Probiotics and prebiotic fiber for constipation associated with Parkinson disease: An RCT
PubMed ID: 27543643
Probiotic + prebiotic fiber significantly increased complete bowel movements and responder rates in constipated Parkinson's patients—meaningful improvement in digestive wellbeing (though multi‑component intervention).
- Randomised clinical trial: mixed soluble/insoluble fibre vs. psyllium for chronic constipation
PubMed ID: 27125883
Plum fiber and psyllium improved bowel movement frequency, stool consistency and straining in chronic constipation—strong, direct evidence for improved overall digestive wellbeing.
- A randomised, double-blind, placebo-controlled clinical study: the effects of a synbiotic, Lepicol, in adults with chronic, functional constipation
PubMed ID: 27776217
Synbiotic product improved bowel frequency, constipation QoL, and decreased laxative use — broad improvement in digestive wellbeing.
- Randomised clinical trial: low-FODMAP rye bread vs. regular rye bread to relieve the symptoms of irritable bowel syndrome
PubMed ID: 27417338
Low‑FODMAP rye reduced bloating and cramps in IBS despite similar fiber — direct symptomatic gut comfort benefit.
- Randomized controlled trial of dietary fiber for the prevention of radiation-induced gastrointestinal toxicity during pelvic radiotherapy
PubMed ID: 28679552
High‑fibre dietary advice during pelvic RT reduced bowel symptom worsening acutely and at 1 year — strong clinical signal for improved gut comfort.
- Effects of fiber and probiotics on diarrhea associated with enteral nutrition in gastric cancer patients: A prospective randomized and controlled trial
PubMed ID: 29069041
Fiber supplementation in enteral feeds greatly reduced diarrhea and shortened LOS—clear improvement in gut comfort/recovery.
- Oligofructose Provides Laxation for Irregularity Associated with Low Fiber Intake
PubMed ID: 29258261
Oligofructose increased stool frequency without worsening GI symptoms—beneficial for general digestive health.
- Substituting whole grains for refined grains in a 6-wk randomized trial favorably affects energy-balance metrics in healthy men and postmenopausal women
PubMed ID: 28179223
Whole‑grain replacement enhanced stool output and net energy loss, reflecting meaningful digestive system effects.
- Starch-entrapped microsphere fibers improve bowel habit but do not exhibit prebiotic capacity in those with unsatisfactory bowel habits: a phase I, randomized, double-blind, controlled human trial
PubMed ID: 28821315
Test fiber and psyllium improved bowel habit metrics, supporting balanced digestion.
- [The efficacy and safety of testa triticum tricum purif in treatment of functional constipation in the late middle-aged and elderly patients: a multicenter randomized controlled clinical trial]
PubMed ID: 28789490
Wheat fiber improved stool frequency and normalized form, supporting a more balanced digestive pattern in constipated older adults.
- Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals
PubMed ID: 28396144
GOS produced large increases in bifidobacteria (strong prebiotic effect) consistent with improved digestive ecosystem health.
- Effect of Fibre Supplementation on Body Weight and Composition, Frequency of Eating and Dietary Choice in Overweight Individuals
PubMed ID: 28212353
PGX was well tolerated in compliant users and reduced eating frequency and waist, suggesting improved GI tolerance/comfort in practice.
- Chain length-dependent effects of inulin-type fructan dietary fiber on human systemic immune responses against hepatitis-B
PubMed ID: 28586162
Long-chain inulin-type fiber enhanced vaccine responses and immune markers, reflecting systemic benefits linked to gut-driven immunity.
- Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study
PubMed ID: 28705786
Synbiotic produced broad improvements in constipation symptoms, stool frequency, and pain—reflects overall GI benefit (prebiotic fiber included).
- Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics
PubMed ID: 29954454
Prebiotic/probiotic interventions increased bifidobacteria and improved colonic permeability — aligns with improved digestive wellbeing.
- In healthy adults, resistant maltodextrin produces a greater change in fecal bifidobacteria counts and increases stool wet weight: a double-blind, randomized, controlled crossover study
PubMed ID: 30527258
Resistant maltodextrin raised bifidobacteria and stool weight—broad digestive benefits
- Impact of dietary fiber supplementation on modulating microbiota-host-metabolic axes in obesity
PubMed ID: 30572270
Pea fiber changed fecal SCFAs and microbiota tied to gut health
- Could resistant starch supplementation improve inflammatory and oxidative stress biomarkers and uremic toxins levels in hemodialysis patients? A pilot randomized controlled trial
PubMed ID: 30468238
Resistant starch reduced systemic inflammation and a gut‑microbial toxin in hemodialysis patients—supports improved gut‑derived wellbeing.
- The effect of prunes on stool output, gut transit time and gastrointestinal microbiota: A randomised controlled trial
PubMed ID: 29398337
Prune intake (high-fiber) increased stool weight and stool frequency in low-fiber adults—direct evidence of easier digestion/bowel activity.
- A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects
PubMed ID: 30541093
Whole‑grain preserved microbiota diversity and metabolic health vs refined wheat—broad digestive/microbial wellbeing benefit.
- Greater improvements in diet quality among overweight participants following a group-based commercial weight loss programme than those receiving support to lose weight in primary care
PubMed ID: 29973211
Increased fiber density in a behavioural programme correlated with better weight and likely improved digestive outcomes as part of overall wellbeing.
- Mediation Analysis as a Means of Identifying Dietary Components That Differentially Affect the Fecal Microbiota of Infants Weaned by Modified Baby-Led and Traditional Approaches
PubMed ID: 30006390
Infant complementary feeding study showed fiber intake explained a substantial portion of microbiota diversity differences — relevant to overall digestive health.
- Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study
PubMed ID: 29307330
Inulin prebiotic RCT showed beneficial microbiota changes (Bifidobacterium, Faecalibacterium) that underpin digestive wellbeing.
- A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
PubMed ID: 30425247
Reduced breath hydrogen and microbiome changes suggest improved colonic fermentation and gut comfort.
- Impact of Agaricus bisporus Mushroom Consumption on Gut Health Markers in Healthy Adults
PubMed ID: 30279332
Mushroom intervention increased stool weight and shifted microbiota—evidence of improved digestive function.
- Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial
PubMed ID: 31509971
PHGG showed multiple improvements (stool form normalization, increased Bifidobacterium, altered bile‑acid conversion) consistent with enhanced digestive wellbeing.
- Efficacy and safety of Gelidium elegans intake on bowel symptoms in obese adults: A 12-week randomized double-blind placebo-controlled trial
PubMed ID: 31027051
Gelidium elegans reduced constipation-related symptoms and abdominal discomfort in an RCT—strong evidence for improved comfort.
- Effect of High Fiber Cereal Intake on Satiety and Gastrointestinal Symptoms during Ramadan
PubMed ID: 31027300
High-fiber breakfast increased bowel-movement frequency and improved bowel habits over 20 days.
- Efficacy of Polydextrose Supplementation on Colonic Transit Time, Bowel Movements, and Gastrointestinal Symptoms in Adults: A Double-Blind, Randomized, Placebo-Controlled Trial
PubMed ID: 30791557
Polydextrose (8–12 g/day) increased bowel-movement frequency and improved constipation symptom scores in a randomized trial.
- Pretreatment Prevotella-to-Bacteroides ratio and markers of glucose metabolism as prognostic markers for dietary weight loss maintenance
PubMed ID: 31285554
Evidence linking habitual fiber, microbiome composition and weight‑regain/metabolic status supports role of fiber in maintaining digestive homeostasis.
- The effect of 'Zesy002' kiwifruit (Actinidia chinensis var. chinensis) on gut health function: a randomised cross-over clinical trial
PubMed ID: 31080591
Strong clinical improvements in stool frequency and consistency in mildly constipated adults indicate meaningful digestive wellbeing benefits.
- Daily intake of wheat germ-enriched bread may promote a healthy gut bacterial microbiota: a randomised controlled trial
PubMed ID: 31325040
Wheat germ increased beneficial gut bacteria and improved GI-related quality-of-life measures — clear wellbeing signal.
- The effect of inulin and resistant maltodextrin on weight loss during energy restriction: a randomised, placebo-controlled, double-blinded intervention
PubMed ID: 31605197
Prebiotic fibre supplementation altered gut microbiota and produced small physiological benefits (BP), supporting overall digestive-microbiome wellbeing.
- Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort
PubMed ID: 32369545
Large observational data support population-level digestive and metabolic benefits of higher fiber intake consistent with long-term digestive wellbeing.
- Nopal fiber (Opuntia ficus-indica) improves symptoms in irritable bowel syndrome in the short term: a randomized controlled trial
PubMed ID: 32935904
IBS RCT with nopal fiber produced high rates of adequate relief and symptom score improvements—strong evidence for improved gut comfort.
- Effect of wheat bran derived prebiotic supplementation on gastrointestinal transit, gut microbiota, and metabolic health: a randomized controlled trial in healthy adults with a slow gut transit
PubMed ID: 31983281
Prebiotic wheat‑bran oligosaccharide clearly altered microbiota and softened stools—broad digestive benefit signal.
- Effects of whole-grain wheat, rye, and lignan supplementation on cardiometabolic risk factors in men with metabolic syndrome: a randomized crossover trial
PubMed ID: 32097450
Whole‑grain rye affected microbiota and produced a small LDL reduction—supports gut and metabolic wellbeing.
- Diet-Associated Inflammation Modulates Inflammation and WNT Signaling in the Rectal Mucosa, and the Response to Supplementation with Dietary Fiber
PubMed ID: 33115783
RS/polydextrose supplementation altered mucosal gene expression and inflammatory markers — supports overall gut health mechanisms.
- The Effect of Soluble Fiber Dextrin on Subjective and Physiological Markers of Appetite: A Randomized Trial
PubMed ID: 33143121
Resistant dextrin increased fermentation (prebiotic activity) though clinical appetite effects were absent; fermentation supports digestive ecosystem health.
- Anti-Heartburn Effects of Sugar Cane Flour: A Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 32570710
Sugar-cane whole-plant fiber reduced GERD symptom scores (heartburn/regurgitation), reflecting symptomatic GI benefit.
- Effects of rice-based and wheat-based diets on bowel movements in young Korean women with functional constipation
PubMed ID: 32322048
Whole-grain diets improved transit time and stool frequency in constipated women, indicating broad digestive benefit.
- Soluble Dietary Fiber Reduces Feeding Intolerance in Severe Acute Pancreatitis: A Randomized Study
PubMed ID: 32141126
Soluble fiber substantially reduced abdominal distension, diarrhea, constipation and feeding intolerance in severe-AP patients—very strong improvement in gut comfort.
- Intake of okara soup for 2 weeks for breakfast improved defecation habits in young Japanese women with self-reported constipation: A randomized, double-blind, placebo-controlled, intervention study
PubMed ID: 32885419
Okara breakfast reduced constipation scores and reported bloating in women with self-reported constipation.
- Dietary Fibres and the Management of Obesity and Metabolic Syndrome: The RESOLVE Study
PubMed ID: 32977595
Fiber increases in the RESOLVE program associated with improved body composition and metabolic markers, supporting a component of overall digestive/metabolic wellbeing.
- Resistant starch supplementation increases crypt cell proliferative state in the rectal mucosa of older healthy participants
PubMed ID: 32279690
Resistant starch produced SCFA increases and mucosal proliferation changes — mechanistic evidence of improved colonic health, a component of digestive wellbeing.
- Gut-microbiota-targeted diets modulate human immune status
PubMed ID: 34256014
High‑fiber diet produced functional microbiome and fecal metabolite changes consistent with more balanced carbohydrate digestion by gut microbes.
- Effects of ID-HWS1000 on the Perception of Bowel Activity and Microbiome in Subjects with Functional Constipation: A Randomized, Double-Blind Placebo-Controlled Study
PubMed ID: 34406877
Synbiotic with fibre improved multiple patient‑reported bowel comfort items vs placebo.
- Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults
PubMed ID: 33865841
Higher vs lower fibre produced small but significant changes in small‑intestinal and colonic permeability → affects digestive balance.
- Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial
PubMed ID: 33561964
Rice bran altered microbiota increasing beneficial genera, which supports digestive health and resilience.
- The effects of abdominal "I LOV U" massage along with lifestyle training on constipation and distension in the elderly with stroke
PubMed ID: 33465382
Abdominal massage reduced belly distension and constipation scores in elderly stroke patients — an intervention that improved subjective gut comfort.
- Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial
PubMed ID: 34226572
Rhamnan sulphate produced clear improvements in bowel frequency, stool output and tolerance in constipated-prone humans — strong evidence for improved digestive wellbeing.
- Effect of a Nutritional Support System to Increase Survival and Reduce Mortality in Patients with COVID-19 in Stage III and Comorbidities: A Blinded Randomized Controlled Clinical Trial
PubMed ID: 35162195
Inpatient trial using 20 g inulin + probiotics produced markedly better survival and less progression — substantial real‑world gut/support outcomes (multi‑nutrient).
- Kitchen Diet vs. Industrial Diets-Impact on Intestinal Barrier Parameters among Stroke Patients
PubMed ID: 35627704
Reduced zonulin and SCFA shifts with blenderized feeding suggest improved gut barrier and more balanced digestion in tube‑fed patients.
- Increasing the diversity of dietary fibers in a daily-consumed bread modifies gut microbiota and metabolic profile in subjects at cardiometabolic risk
PubMed ID: 35311446
Multi‑fiber product changed microbiome composition and improved metabolic markers—contributes to digestive and cardiometabolic wellbeing.
- [Efficacy of newly developed kombucha-based specialized food product for treatment of constipation-predominant irritable bowel syndrome]
PubMed ID: 36394933
Inulin‑enriched kombucha normalized stool form and frequency in IBS‑C—evidence for restoration of balanced bowel function.
- Two Gold Kiwifruit Daily for Effective Treatment of Constipation in Adults-A Randomized Clinical Trial
PubMed ID: 36235798
Kiwifruit increased complete bowel movements, softened stool, and reduced straining—clear benefit for digestion.
- Use of Faecal Transplantation with a Novel Diet for Mild to Moderate Active Ulcerative Colitis: The CRAFT UC Randomised Controlled Trial
PubMed ID: 34514495
Dietary exclusion resulting in remission in UC implies major improvements in digestive wellbeing for affected patients.
- Short-Term Effect of Additional Daily Dietary Fibre Intake on Appetite, Satiety, Gastrointestinal Comfort, Acceptability, and Feasibility
PubMed ID: 36235865
Barley fiber changed stool consistency and produced early GI symptoms, indicating an effect on digestive balance during adaptation.
- Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial
PubMed ID: 37078654
Largest and most direct trial: fiber formulas improved bowel movement frequency, stool form and increased beneficial bacteria—comprehensive digestive benefit.
- Laser acupuncture improving functional chronic constipation in children: a randomized controlled trial
PubMed ID: 36790507
Clinical pediatric constipation management including fiber produced improved stool outcomes, supporting balanced digestion.
- The Effects of Agave Fructans in a Functional Food Consumed by Patients with Irritable Bowel Syndrome with Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 37630717
Agave fructans improved stool frequency, consistency and IBS‑C QOL—clear evidence of easier bowel function.
- Effect of Continuous Ingestion of Bifidobacteria and Dietary Fiber on Improvement in Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 37836458
Inulin + B. animalis increased bifidobacteria and improved cognition; microbiota change supports digestive wellbeing.
- Agave tequilana Fructans Versus Psyllium plantago for Functional Constipation : Randomized Double-blind Clinical Trial
PubMed ID: 37389917
Agave fructans improved bowel movements, stool consistency and symptom‑related QoL in functional constipation—strong overall digestive benefit.
- Low-protein diet supplemented with inulin lowers protein-bound toxin levels in patients with stage 3b-5 chronic kidney disease: a randomized controlled study
PubMed ID: 37409723
Inulin lowered uremic toxins and inflammation in CKD—improves gut metabolic health and wellbeing.
- Blueberries Improve Abdominal Symptoms, Well-Being and Functioning in Patients with Functional Gastrointestinal Disorders
PubMed ID: 37242279
Blueberry RCT increased proportion reporting abdominal symptom relief and better well‑being vs placebo in FGID.
- Amelioration of intestinal barrier function and reduction of blood lead level in adult women with recurrent spontaneous abortion by a novel product of dietary fiber mixture, Holofood
PubMed ID: 37420277
Randomized trial of a dietary‑fiber blend (Holofood) lowered blood lead and improved gut barrier biomarkers—supports improved intestinal comfort/health.
- A low FODMAP diet plus traditional dietary advice versus a low-carbohydrate diet versus pharmacological treatment in irritable bowel syndrome (CARIBS): a single-centre, single-blind, randomised controlled trial
PubMed ID: 38643782
Dietary manipulation of fermentable carbohydrates improved IBS symptoms, implying easier digestion for many patients.
- Impact of resistant starch type 3 on fecal microbiota and stool frequency in Thai adults with chronic constipation randomized clinical trial
PubMed ID: 39543201
12‑week resistant starch (9 g/day) RCT improved stool consistency and frequency, indicating easier digestion/defecation.
- Effects of dietary fiber on maternal health in pregnant women with metabolic syndrome risk: a randomized controlled trial
PubMed ID: 38809131
Higher dietary/soluble fiber during pregnancy linked to fewer constipation medication needs and better metabolic adaptations, favoring digestive wellbeing.
- Beneficial Effects of Synbiotics on the Gut Microbiome in Individuals with Low Fiber Intake: Secondary Analysis of a Double-Blind, Randomized Controlled Trial
PubMed ID: 38999830
Synbiotic (inulin + probiotics) increased SCFA‑producing taxa in low‑fiber participants — general microbiome benefit for digestive wellbeing.
- Comprehensive modulatory effects of whole grain consumption on immune-mediated inflammation in middle-aged and elderly community residents: A real-world randomized controlled trial
PubMed ID: 39260062
Whole‑grain substitution increased fecal butyrate and favorably modulated immune markers — supports general digestive health.
- Twelve Weeks of Daily Lentil Consumption Improves Fasting Cholesterol and Postprandial Glucose and Inflammatory Responses-A Randomized Clinical Trial
PubMed ID: 38337705
Daily lentils improved metabolic markers without increasing GI symptoms — pragmatic support for digestive wellbeing with a fiber‑rich food.
- Adaptation to tolerate high doses of arabinoxylan is associated with fecal levels of Bifidobacterium longum
PubMed ID: 38860973
Arabinoxylan showed symptom adaptation with correlation to microbiome markers; indicates improved tolerance/gut comfort over time.
- A Randomized, Double-Blind, Placebo-Controlled Trial: Efficacy of Opuntia ficus-indica Prebiotic Supplementation in Subjects with Gut Dysbiosis
PubMed ID: 38474715
Opuntia extract produced significant GI symptom improvements (GIQLI) vs placebo, indicating improved gut comfort.
- [Multi-strain probiotic combined with dietary fiber is an effective factor in the nutritional support of immunity in athletes]
PubMed ID: 38809796
Probiotic + corn‑bran produced immune/marker improvements consistent with better gut health; combined intervention limits attribution solely to fiber but overall digestive wellbeing likely improved.
- A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial
PubMed ID: 39843443
Legume (high‑fibre) diet improved microbiome and metabolic markers associated with improved digestive health.
- Gut microbiome predicts personalized responses to dietary fiber in prediabetes: a randomized, open-label trial
PubMed ID: 41390484
Large fiber supplement RCT showed clinically relevant metabolic and microbiome signals supporting digestive health for responders.
- Synbiotics protected radiation-induced tissue damage in rectal cancer patients: A controlled trial
PubMed ID: 40250086
Synbiotic reduced mucosal inflammation and fibrosis around radiotherapy, implying improved local gut comfort.
- Baseline intestinal microbiota composition influences response to a real-world dietary fiber intervention
PubMed ID: 41198696
Short‑term resistant starch/inulin improved bowel symptoms (GSRS/Bristol) in microbiome‑dependent responders.
- Fiber, lactose and fat-modified diet for the prevention of gastrointestinal chemo-radiotherapy-induced toxicity in patients with cervical cancer: Randomized clinical trial
PubMed ID: 39848009
A fiber‑adjusted diet during pelvic chemoradiotherapy reduced mild constipation and GI discomfort risk.
- Tolerability and efficacy of an enteral formula containing partially hydrolyzed guar gum in patients following gastrointestinal surgery: A prospective, multicenter, open-label, randomized controlled study
PubMed ID: 41483486
PHGG formula improved GI tolerability (less abdominal distension and better tolerance) vs fiber‑free formula in postoperative patients.
- Mitigating digestive complications and neutropenia in pediatric leukemia through a Persian medicine product of whole wheat-based dietary intervention: a randomized triple-blind placebo-controlled trial
PubMed ID: 39847133
Wheat‑bran product delivered consistent improvements across GI symptoms (pain, bloating, constipation) in a randomized trial.
- Tolerance of high fibre supplementation among participants in a randomised trial to reduce cancer risk among Alaska Native peoples: Alaska FIRST
PubMed ID: 40999949
High resistant‑starch supplement reduced reports of diarrhea and abdominal pain vs digestible starch (RCT), indicating easier digestion for some outcomes.
- Comparison of Low-Gluten Diets Rich in Oats or Rice-A 6-Week Randomized Clinical Trial With Metabolically Challenged Volunteers
PubMed ID: 40331457
Oat‑rich diet increased fibre intake and improved bowel habits and some GI symptom scores.
- Resistant starch improves Parkinson's disease symptoms through restructuring of the gut microbiome and modulating inflammation
PubMed ID: 41389850
Resistant starch improved microbiome composition, SCFAs and symptoms—strong evidence for improved overall digestive wellbeing.
- Effect of computer-based gaming on constipation management in children: A randomized controlled trial
PubMed ID: 41265369
Educational intervention increased fibre/fluid intake and improved stool patterns in children with constipation—clear evidence of easier digestion/evacuation.
- Pilot investigation of an oligosaccharide blend in adults with asthma - a double-blind, randomised, placebo-controlled, 4-arm crossover trial
PubMed ID: 41192744
Soluble oligosaccharide increased plasma SCFAs (a marker of fermentation) which can be linked to gut comfort, though asthma trial context limits directness.
- A randomised, placebo-controlled trial in healthy humans of modified cellulose or psyllium evaluating the role of gelation in altering colonic gas production during inulin co-administration
PubMed ID: 41636227
Direct randomized human trial showing psyllium alters fermentation and transit—strong mechanistic support for improved digestive comfort/overall gut function.
Weight management (242)
- Comparative effectiveness of plant-based diets for weight loss: a randomized controlled trial of five different diets
PubMed ID: 25592014
Vegan (higher‑fiber) diet led to greater weight loss at 6 months, which would help maintain waistline; effect is from whole‑diet change.
- Dietary Patterns During Weight Loss Maintenance vs. Weight Regain: A Secondary Analysis of the Look AHEAD Trial
PubMed ID: 41599940
Prospective observational data: those who maintained weight loss had higher fruit/vegetable (fiber‑rich) intake—supports a role for fiber‑rich diets in weight maintenance.
- Development and empirical evaluation of a dietary intervention programme for individuals with prediabetes based on the health action process approach: A randomised controlled trial
PubMed ID: 41421300
HAPA‑based program increased fibre‑rich intakes and produced BMI improvements in people with prediabetes—direct weight‑management evidence.
- Comparison of Low-Gluten Diets Rich in Oats or Rice-A 6-Week Randomized Clinical Trial With Metabolically Challenged Volunteers
PubMed ID: 40331457
Oat group had a small reduction in waist circumference alongside higher fibre intake.
- Effects of brown rice bran on appetite and depression in metabolic syndrome: a secondary analysis of an open-label randomised controlled trial
PubMed ID: 41190469
Increased fullness with brown rice bran may support reduced intake and weight management over time (short‑term RCT evidence).
- NUTRIOSE® soluble fibre supplementation as an effective dietary strategy to improve glycaemic response
PubMed ID: 40167751
NUTRIOSE decreased trunk % body fat and increased trunk FFM in female subgroup—relevant to waistline.
- Supplementing the standard diet with brown rice bran powder might effectively improve the metabolic syndrome characteristics and antioxidant status: an open label randomized controlled trial
PubMed ID: 39775811
Brown rice bran RCT showed weight reduction in metabolic syndrome participants over 8 weeks.
- Trajectories of adherence to an obesogenic dietary pattern and changes in diet quality, food intake, and adiposity during adolescence
PubMed ID: 40055723
Observational evidence links persistent low‑fiber, energy‑dense dietary patterns to greater central adiposity in adolescents.
- Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study
PubMed ID: 40057729
High‑fiber menu plan led to meaningful weight loss over 20 weeks (multi‑component intervention).
- Effects of combined prebiotic fiber supplementation and weight loss counseling in adults with metabolic dysfunction-associated steatotic liver disease: a randomized controlled trial
PubMed ID: 40172664
Greater trunk fat decrease with oligofructose‑inulin suggests benefit for waistline/central adiposity.
- A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial
PubMed ID: 39843443
Legume‑rich (high‑fibre) diet produced greater weight/fat loss and favorable metabolic changes vs control.
- Effects of the dyadic FirstStep2Health intervention on parents' behaviour and anthropometric outcomes: a secondary analysis of a cluster randomised trial
PubMed ID: 39638602
Family intervention that increased parental fiber intake was associated with lower % body fat—supports weight management role of fiber as part of behavior change.
- Impact of diet intervention on visceral adipose tissue and hepatic fat in patients with obesity or type 2 diabetes: a randomized trial
PubMed ID: 39271914
High‑fiber 3G rice within a 12‑week diet reduced visceral adipose tissue and body weight vs usual diet — supports waistline/abdominal fat reductions.
- A Randomized Trial of the Efficacy of Three Weight Loss Diet Interventions in Overweight/Obese with Polycystic Ovary Syndrome
PubMed ID: 38988067
High‑protein plus high‑dietary‑fiber diet produced the largest visceral fat area reduction among tested calorie‑restricted diets.
- Diet order significantly affects energy balance for diets varying in macronutrients but not ultraprocessing in crossover studies without a washout period
PubMed ID: 39163976
Inpatient diet studies showed that higher fiber/food mass was associated with substantially greater weight and fat loss.
- Long-term clinical efficacy of dietary fiber supplementation in middle-aged and elderly prediabetic patients
PubMed ID: 39406174
Mixed fiber supplementation reduced central obesity measures over 6 months, supporting waistline maintenance.
- Effect of prebiotic fiber on physical function and gut microbiota in adults, mostly women, with knee osteoarthritis and obesity: a randomized controlled trial
PubMed ID: 38713231
Inulin reduced trunk fat in obese adults, a direct waistline benefit.
- A whole food, plant-based randomized controlled trial in metastatic breast cancer: feasibility, nutrient, and patient-reported outcomes
PubMed ID: 38553649
Whole‑food plant‑based intervention markedly increased fiber intake and produced substantial weight loss in a randomized pilot.
- Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota
PubMed ID: 38409604
Resistant starch produced significant visceral and subcutaneous abdominal fat loss in an RCT—direct waistline benefit.
- [Effects of three medical nutrition therapies for weight loss on metabolic parameters and androgen level in overweight/obese patients with polycystic ovary syndrome]
PubMed ID: 37032153
High‑protein plus high‑fiber diet produced larger weight and BMI reductions in overweight/obese women with PCOS versus control diet.
- The ALINFA Intervention Improves Diet Quality and Nutritional Status in Children 6 to 12 Years Old
PubMed ID: 37242258
ALINFA child intervention increased fiber intake and was associated with within‑group decreases in BMI/BMI z‑score and leptin.
- HIGH-FIBER DIET PROMOTES METABOLIC, HORMONAL, AND SATIETY EFFECTS IN OBESE WOMEN ON A SHORT-TERM CALORIC RESTRICTION
PubMed ID: 37556741
Short‑term high‑fiber calorie‑restricted diet improved glycaemic markers and hunger hormone suppression—supports weight management in obesity.
- High-fiber diet and rope-skipping benefit cardiometabolic health and modulate gut microbiota in young adults: A randomized controlled trial
PubMed ID: 37803759
High‑fiber diet intervention in undergraduates reduced percent body fat and waist circumference vs baseline.
- Effects of Synbiotic Supplementation on Metabolic Syndrome Traits and Gut Microbial Profile among Overweight and Obese Hong Kong Chinese Individuals: A Randomized Trial
PubMed ID: 37836532
Diet + synbiotic arm (fiber‑rich) had the largest proportion of meaningful weight loss and improved body metrics.
- Dietary Supplementation with Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), Reduces Visceral Fat and Hyperlipidemia in Inhabitants of a Rural Community in Mexico
PubMed ID: 36004709
Pleurotus mushroom addition reduced visceral fat in women in a small community trial.
- Effect of sodium alginate supplementation on weight management and reproductive hormones in polycystic females
PubMed ID: 36047511
Sodium alginate showed improvements in weight‑related measures (likely includes waist/central adiposity).
- Nutritional Impact and Eating Pattern Changes in Schizophrenic Spectrum Disorders after Health Education Program on Symbiotic Dietary Modulation Offered by Specialised Psychiatric Nursing-Two-Arm Randomised Clinical Trial
PubMed ID: 36558548
Dietary counselling improved anthropometrics including waist measures in intervention group.
- Impact of high prebiotic and probiotic dietary education in the SARS-CoV-2 era: improved cardio-metabolic profile in schizophrenia spectrum disorders
PubMed ID: 36510155
Six‑month program produced a significant reduction in waist circumference (robust anthropometric finding).
- Increasing the diversity of dietary fibers in a daily-consumed bread modifies gut microbiota and metabolic profile in subjects at cardiometabolic risk
PubMed ID: 35311446
Multi‑fiber bread improved insulin sensitivity and lipids; these changes support weight management though weight itself was not the primary endpoint.
- Probiotics Plus Dietary Fiber Supplements Attenuate Olanzapine-Induced Weight Gain in Drug-Naïve First-Episode Schizophrenia Patients: Two Randomized Clinical Trials
PubMed ID: 35569003
Probiotics + dietary fiber substantially attenuated olanzapine‑induced weight gain (≈−3.45 kg difference over 12 wk)—clinically meaningful weight‑management effect in this context.
- Longitudinal association of dietary carbohydrate quality with visceral fat deposition and other adiposity indicators
PubMed ID: 36084360
Large study showed higher carb quality (fiber/wholegrain) linked to reductions in visceral and total fat—strong waistline signal.
- Does a Plant-Based Diet Stand Out for Its Favorable Composition for Heart Health? Dietary Intake Data from a Randomized Controlled Trial
PubMed ID: 36364858
Whole‑food PBD raised fiber and produced modest weight loss and waist improvements in RCT subgroup.
- Changes in Food and Nutrient Intake and Diet Quality on a Low-Fat Vegan Diet Are Associated with Changes in Body Weight, Body Composition, and Insulin Sensitivity in Overweight Adults: A Randomized Clinical Trial
PubMed ID: 35452873
Vegan diet with increased plant foods/fiber correlated with weight/fat loss and waist changes.
- Diverging metabolic effects of 2 energy-restricted diets differing in nutrient quality: a 12-week randomized controlled trial in subjects with abdominal obesity
PubMed ID: 35102369
High‑quality (higher‑fiber) energy‑restricted diet achieved significantly more weight loss vs low‑quality ER diet.
- The effects of probiotics plus dietary fiber on antipsychotic-induced weight gain: a randomized clinical trial
PubMed ID: 35508529
Probiotics + dietary fiber prevented antipsychotic‑associated weight gain compared with placebo (clinically meaningful result).
- Flaxseed Mucilage (IQP-LU-104) Reduces Body Weight in Overweight and Moderately Obese Individuals in a 12-week, Three-Arm, Double-Blind, Randomized, and Placebo-Controlled Clinical Study
PubMed ID: 35130547
High‑dose flaxseed mucilage RCT produced marked weight and fat‑mass reductions (strong, direct evidence).
- Consuming a Protein and Fiber-Based Supplement Preload Promotes Weight Loss and Alters Metabolic Markers in Overweight Adults in a 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 35212740
Twice‑daily HPF preload led to greater weight loss vs isocaloric control in a randomized, double‑blind trial.
- The effect of intermittent fasting diets on body weight and composition
PubMed ID: 36184206
Diet trial where fiber intake rose in arms that lost weight; fiber likely contributed though multiple dietary factors were involved.
- Dose-Dependent Associations of Dietary Glycemic Index, Glycemic Load, and Fiber With 3-Year Weight Loss Maintenance and Glycemic Status in a High-Risk Population: A Secondary Analysis of the Diabetes Prevention Study PREVIEW
PubMed ID: 34045241
Large longitudinal study showed fiber had inverse associations with waist circumference (modest protective effect).
- A hypocaloric diet rich in high fiber rye foods causes greater reduction in body weight and body fat than a diet rich in refined wheat: A parallel randomized controlled trial in adults with overweight and obesity (the RyeWeight study)
PubMed ID: 34620312
Randomized trial: replacing refined wheat with high‑fiber rye during calorie restriction produced ~1.08 kg greater weight loss and more body‑fat reduction — direct support.
- Dietary Blueberry and Soluble Fiber Supplementation Reduces Risk of Gestational Diabetes in Women with Obesity in a Randomized Controlled Trial
PubMed ID: 33693835
Soluble fiber + blueberries markedly reduced gestational weight gain in obese pregnant women (strong effect on waistline/weight gain).
- Policaptil Gel Retard Intake Reduces Postprandial Triglycerides, Ghrelin and Appetite in Obese Children: A Clinical Trial
PubMed ID: 31947628
Acute reductions in appetite and triglycerides in obese children after premeal fiber suggest support for weight management.
- Effect of a functional fibre supplement on glycemic control when added to a year-long medically supervised weight management program in adults with type 2 diabetes
PubMed ID: 32642971
PGX produced modest sustained weight loss at 52 weeks when used with a weight‑loss program (support for waistline maintenance).
- Dietary Fibres and the Management of Obesity and Metabolic Syndrome: The RESOLVE Study
PubMed ID: 32977595
RESOLVE program analysis showed that increases in fiber intake were the nutritional variable most consistently predicting reductions in central fat, fat mass and improved metabolic markers.
- Pretreatment Prevotella-to-Bacteroides ratio and salivary amylase gene copy number as prognostic markers for dietary weight loss
PubMed ID: 32034403
High‑fiber New Nordic Diet led to greater weight loss in participants with certain Prevotella/Bacteroides ratios (microbiome‑dependent effect).
- Cocoa and unripe banana flour beverages improve anthropometric and biochemical markers in overweight women: A randomised double-blind study
PubMed ID: 32019434
Cocoa + unripe-banana-fiber drink produced a modest but statistically significant reduction in waist circumference over 6 weeks.
- A Coaching Program to Improve Dietary Intake of Patients with CKD: ENTICE-CKD
PubMed ID: 32111701
Increased fiber intake in a telehealth program was associated with weight loss (exploratory), consistent with waistline maintenance benefits.
- Carbohydrate quality changes and concurrent changes in cardiovascular risk factors: a longitudinal analysis in the PREDIMED-Plus randomized trial
PubMed ID: 31868210
Large lifestyle trial: better carbohydrate quality (more fiber) correlated with modest but consistent weight improvements at 12 months.
- Effect of 12-Week Interventions Involving Nordic Walking Exercise and a Modified Diet on the Anthropometric Parameters and Blood Lipid Profiles in Overweight and Obese Ex-Coal Miners
PubMed ID: 32209798
Reduced‑calorie/high‑fiber diet arm lost more weight than other groups in a 12‑week program (multicomponent intervention).
- Defatted flaxseed flour improves weight loss and lipid profile in overweight and obese adults: a randomized controlled trial
PubMed ID: 32966475
Defatted flaxseed biscuits produced significant weight and BMI reductions in overweight/obese adults over 60 days.
- Visceral Fat-Reducing Effect and Safety of Continuous Consumption of Beverage Containing Resistant Maltodextrin: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial
PubMed ID: 33132344
Resistant maltodextrin RCT produced a small but significant reduction in visceral fat area (direct waistline-relevant outcome).
- Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort
PubMed ID: 32369545
Prospective data associate higher fiber intake with lower incidence of metabolic disease and mortality, consistent with long-term weight/health benefits.
- Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults: A Randomized Clinical Trial
PubMed ID: 33252690
RCT low‑fat vegan (higher‑fiber) diet led to ~6 kg weight loss over 16 weeks—strong evidence that higher-fiber diets can aid weight loss in this setting.
- Pretreatment Fasting Glucose and Insulin as Determinants of Weight Loss on Diets Varying in Macronutrients and Dietary Fibers-The POUNDS LOST Study
PubMed ID: 30861997
Large trial analysis showed higher dietary fiber intake during weight-loss interventions was associated with substantially greater long-term weight loss (strongest direct evidence here).
- Weight loss at your fingertips: personalized nutrition with fasting glucose and insulin using a novel statistical approach
PubMed ID: 30967642
High-fiber New Nordic Diet produced greater weight loss in certain biomarker-defined subgroups — supportive for waistline maintenance.
- Pretreatment Prevotella-to-Bacteroides ratio and markers of glucose metabolism as prognostic markers for dietary weight loss maintenance
PubMed ID: 31285554
Clear RCT evidence: high habitual fiber intake was associated with reduced weight regain depending on gut microbiome and metabolic status (strong relevance to weight maintenance).
- Prevotella Abundance Predicts Weight Loss Success in Healthy, Overweight Adults Consuming a Whole-Grain Diet Ad Libitum: A Post Hoc Analysis of a 6-Wk Randomized Controlled Trial
PubMed ID: 31504699
Post-hoc analysis: individuals with higher Prevotella lost more weight on a higher-fiber whole-grain diet vs refined—suggests fiber-responsive weight effects.
- Effect of an individualised high-protein, energy-restricted diet on anthropometric and cardio-metabolic parameters in overweight and obese Malaysian adults: a 6-month randomised controlled study
PubMed ID: 30761964
Personalized high‑protein, higher‑fibre diet achieved significant weight and fat loss over 6 months—strong, clinically relevant evidence.
- Effects of Whole Grain Wheat Bread on Visceral Fat Obesity in Japanese Subjects: A Randomized Double-Blind Study
PubMed ID: 29671172
Whole‑grain (higher fibre) substitution modestly reduced visceral fat area—evidence supporting waistline maintenance.
- A proof-of-concept study to evaluate the efficacy and safety of BTI320 on post-prandial hyperglycaemia in Chinese subjects with pre-diabetes
PubMed ID: 30170579
Galactomannan (chewable) reduced post‑meal glucose excursions and produced a statistically significant small weight reduction at low dose.
- Success in Achieving the Targets of the 20-Year Infancy-Onset Dietary Intervention: Association With Insulin Sensitivity and Serum Lipids
PubMed ID: 30072407
Long-term counseling to meet fiber/whole-grain targets in children linked to better insulin sensitivity and lipid profile and favorable body composition trajectories.
- [Comparison of a commercially available, formula-based nutritional therapy enriched with oats fiber with a non-formula isocaloric therapy to treat non-alcoholic fatty liver disease (NAFLD) - a randomized, controlled intervention trial]
PubMed ID: 30304749
Oat-fiber formula helped reduce liver fat and weight in obese patients with fatty liver compared with control.
- A Plant-Based High-Carbohydrate, Low-Fat Diet in Overweight Individuals in a 16-Week Randomized Clinical Trial: The Role of Carbohydrates
PubMed ID: 30223451
Randomized 16-week plant-based, high-fiber diet produced substantial reductions in BMI, fat mass and visceral fat; strong RCT evidence for weight management.
- Postprandial glucose-lowering effect of premeal consumption of protein-enriched, dietary fiber-fortified bar in individuals with type 2 diabetes mellitus or normal glucose tolerance
PubMed ID: 29502350
Acute increases in satiety and reductions in postprandial glucose/insulin from a fiber-rich premeal bar support mechanisms helpful for weight management.
- Greater improvements in diet quality among overweight participants following a group-based commercial weight loss programme than those receiving support to lose weight in primary care
PubMed ID: 29973211
Large randomized trial: increasing fibre density in a commercial weight-loss programme was associated with greater weight loss vs standard care.
- A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects
PubMed ID: 30541093
Whole‑grain wheat prevented an increase in liver fat that occurred with refined wheat—protective metabolic effect relevant to weight/fat distribution.
- Impact of Diets Rich in Whole Grains and Fruits and Vegetables on Cardiovascular Risk Factors in Overweight and Obese Women: A Randomized Clinical Feeding Trial
PubMed ID: 29702040
Whole-grain–rich weight-loss diet produced larger improvements in weight and waist vs comparison diets—strong support for fiber‑rich foods aiding weight management.
- Weight loss and metabolic health effects from energy-restricted Mediterranean and Central-European diets in postmenopausal women: A randomized controlled trial
PubMed ID: 30042488
Higher fiber intake in the Central‑European diet correlated with greater visceral fat loss among adherent postmenopausal women.
- Impact of dietary fiber supplementation on modulating microbiota-host-metabolic axes in obesity
PubMed ID: 30572270
Pea fiber trial linked microbiota changes (Lachnospira) to less weight gain
- Obesity and mental health improvement following nutritional education focusing on gut microbiota composition in Japanese women: a randomised controlled trial
PubMed ID: 30523432
Nutrition education increasing fiber intake was associated with weight loss and waist reduction
- Associations between fiber intake and Body Mass Index (BMI) among African-American women participating in a randomized weight loss and maintenance trial
PubMed ID: 29510372
Higher habitual fiber intake associated with lower BMI in longitudinal weight-loss program
- Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention
PubMed ID: 28883543
High‑fiber whole‑food diet caused significantly greater waist circumference reduction in participants with high Prevotella/Bacteroides ratio.
- [Effect of quinua (Chenopodium quinoa)consumption as a coadjuvant in nutritional intervention in prediabetic subjects]
PubMed ID: 29130716
Processed quinoa led to a short-term BMI reduction in prediabetic participants over 28 days.
- Effect of Fibre Supplementation on Body Weight and Composition, Frequency of Eating and Dietary Choice in Overweight Individuals
PubMed ID: 28212353
PGX produced a significant −2.5 cm waist circumference change (intention-to-treat), supporting waistline maintenance/reduction.
- The Effect of a Diet Moderately High in Protein and Fiber on Insulin Sensitivity Measured Using the Dynamic Insulin Sensitivity and Secretion Test (DISST)
PubMed ID: 29186908
Higher-protein/higher-fiber diet decreased total and truncal fat modestly, supportive of waistline benefits.
- Increased fibre and reduced trans fatty acid intake are primary predictors of metabolic improvement in overweight polycystic ovary syndrome-Substudy of randomized trial between diet, exercise and diet plus exercise for weight control
PubMed ID: 28727165
In PCOS women, increased dietary fiber intake was the strongest predictor of BMI reduction in a lifestyle trial substudy.
- Portion controlled ready-to-eat meal replacement is associated with short term weight loss: a randomised controlled trial
PubMed ID: 28917231
Two‑meal replacement cereal increased fiber intake and produced a small but significant short‑term waist circumference reduction.
- Impact of a Plant-Based Diet and Support on Mitigating Type 2 Diabetes Mellitus in Latinos Living in Medically Underserved Areas
PubMed ID: 28503930
Supported high‑fiber, low‑fat diet in people with diabetes likely aided waist/weight control alongside glycemic improvement.
- Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial
PubMed ID: 29162875
Fibre‑rich diet reduced liver fat substantially (often accompanies improvements in body composition), supporting weight management indirectly.
- Substituting whole grains for refined grains in a 6-wk randomized trial favorably affects energy-balance metrics in healthy men and postmenopausal women
PubMed ID: 28179223
Whole‑grain substitution increased net daily energy loss (~92 kcal/d), plausibly aiding weight control.
- A High-Carbohydrate, High-Fiber, Low-Fat Diet Results in Weight Loss among Adults at High Risk of Type 2 Diabetes
PubMed ID: 28954840
Large cohort analysis found higher high‑fiber carbohydrate intake predicted greater 1‑yr weight loss, independent of calorie change.
- Prebiotic supplementation improves appetite control in children with overweight and obesity: a randomized controlled trial
PubMed ID: 28228425
Oligofructose reduced intake and produced modest BMI z‑score reduction in children (per‑protocol).
- Acute effects of different dietary polysaccharides added in milk on food intake, postprandial appetite and glycemic responses in healthy young females
PubMed ID: 27352777
Acute reductions in subsequent meal intake with viscous fibers support potential for reduced energy intake and weight management over time (short‑term RCT evidence).
- Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial)
PubMed ID: 27733151
Psyllium supplementation led to ~2.9 kg weight loss over 8 weeks in people with T2D.
- Short- and Long-Term Effects of Wholegrain Oat Intake on Weight Management and Glucolipid Metabolism in Overweight Type-2 Diabetics: A Randomized Control Trial
PubMed ID: 27618090
Adding whole‑grain oats produced modest weight loss at 1 year in overweight T2D subjects.
- Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial
PubMed ID: 26811130
15 g/day pea fiber caused small but significant reductions in body weight and body fat over 12 weeks.
- Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial
PubMed ID: 27810310
Prebiotic+probiotic combination reduced waist circumference (per‑protocol analyses) in overweight adults.
- Effects of oatmeal and corn flakes cereal breakfasts on satiety, gastric emptying, glucose, and appetite-related hormones
PubMed ID: 25612907
Oatmeal reduced subsequent intake acutely, which may support weight control over time though no long‑term weight data here.
- Effects of total fibre or resistant starch-rich diets within lifestyle intervention in obese prediabetic adults
PubMed ID: 25588971
12‑month lifestyle intervention with high‑fiber advice improved 2‑h glycaemia and was part of weight‑oriented program; modest weight/ metabolic effects.
- Reduction in food away from home is associated with improved child relative weight and body composition outcomes and this relation is mediated by changes in diet quality
PubMed ID: 25963602
Large behavioral trial: reduced eating out increased fiber intake and statistically mediated improvements in zBMI and body fat in children.
- Processes of behavior change and weight loss in a theory-based weight loss intervention program: a test of the process model for lifestyle behavior change
PubMed ID: 25592314
Behavioral intervention led to sustained increased fiber intake and modest short‑term weight loss—supports role of fiber within lifestyle change.
- Weight Maintenance with Litramine (IQP-G-002AS): A 24-Week Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 26435849
Randomized double‑blind trial showed Litramine helped maintain weight and reduce fat mass vs placebo over 24 weeks (clinically meaningful).
- Single-component versus multicomponent dietary goals for the metabolic syndrome: a randomized trial
PubMed ID: 25686165
Large randomized trial: single‑goal (≥30 g/day) fiber intervention produced modest weight loss and metabolic improvements similar to AHA diet.
- α-Galacto-oligosaccharides Dose-Dependently Reduce Appetite and Decrease Inflammation in Overweight Adults
PubMed ID: 26180243
α‑GOS reduced short‑term energy intake and increased satiety, mechanistically supportive of weight management.
- A Randomized Controlled Trial Translating the Diabetes Prevention Program to a University Worksite, Ohio, 2012-2014
PubMed ID: 26605710
Worksite DPP produced clinically meaningful weight loss and increased fiber intake modestly; fiber plausibly contributed as part of the intervention.
- LA sprouts randomized controlled nutrition and gardening program reduces obesity and metabolic risk in Latino youth
PubMed ID: 25960146
Randomized gardening/nutrition RCT increased fiber intake and yielded modest but significant reductions in BMI z‑score and waist circumference in youth.
- Satiety effects of a whole-grain fibre composite ingredient: reduced food intake and appetite ratings
PubMed ID: 25138661
Acute lower energy intake at subsequent meals with a viscous whole‑grain fibre ingredient supports potential for weight‑management effects.
- Morning meal more efficient for fat loss in a 3-month lifestyle intervention
PubMed ID: 24809437
Mediterranean high‑fiber diet with timing produced significantly greater waist circumference reduction vs control—direct evidence for waistline benefit.
- Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity
PubMed ID: 24997634
Dietary intervention with higher fiber improved metabolic markers and reduced triglycerides, consistent with waistline benefits.
- Lifestyle intervention and cardiovascular disease risk reduction in low-income Hispanic immigrant women participating in the Illinois WISEWOMAN program
PubMed ID: 24469546
Lifestyle program produced a sustained fiber intake increase and a small BMI reduction at one year.
- Resistant starch type 4-enriched diet lowered blood cholesterols and improved body composition in a double blind controlled cross-over intervention
PubMed ID: 24478107
RS4 replacement modestly reduced waist circumference and percent body fat in some subgroups over 26 weeks.
- Effect of two dietary fibers on satiety and glycemic parameters: a randomized, double-blind, placebo-controlled, exploratory study
PubMed ID: 24886409
Oligofructose+pectin reduced energy intake trends and improved insulin sensitivity that may aid waistline maintenance.
- Effects of Gum Arabic ingestion on body mass index and body fat percentage in healthy adult females: two-arm randomized, placebo controlled, double-blind trial
PubMed ID: 23241359
30 g/day gum arabic reduced BMI and body‑fat % modestly over 6 weeks in healthy women.
- An enriched, cereal-based bread affects appetite ratings and glycemic, insulinemic, and gastrointestinal hormone responses in healthy adults in a randomized, controlled trial
PubMed ID: 25644342
Increased postprandial fullness and lower glycemic/insulin responses after fiber+protein bread could support reduced intake and weight control over time.
- Sustainable weight loss among overweight and obese lactating women is achieved with an energy-reduced diet in line with dietary recommendations: results from the LEVA randomized controlled trial
PubMed ID: 25088520
Energy-reduced diet that increased fiber produced sustained weight loss (fiber part of multi-component diet).
- Dietary determinants of hepatic steatosis and visceral adiposity in overweight and obese youth at risk of type 2 diabetes
PubMed ID: 24522441
Higher fiber intake associated with lower odds of visceral obesity in overweight adolescents (direct association to central adiposity).
- Regular breakfast consumption and type 2 diabetes risk markers in 9- to 10-year-old children in the child heart and health study in England (CHASE): a cross-sectional analysis
PubMed ID: 25181492
High-fiber breakfasts associated with lower insulin resistance in children (metabolic implication for waist/central fat maintenance).
- The effects of functional fiber on postprandial glycemia, energy intake, satiety, palatability and gastrointestinal wellbeing: a randomized crossover trial
PubMed ID: 25066659
Functional fibers lowered glycemic spikes and reduced subsequent energy intake — plausible support for weight management over time.
- Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
PubMed ID: 25500202
High‑quality outcomes: acute energy intake reduction and 24‑week prevention of weight gain and reduction in visceral/liver fat.
- Changes in visceral adiposity and serum cholesterol with a novel viscous polysaccharide in Japanese adults with abdominal obesity
PubMed ID: 23512917
PGX reduced waist circumference and visceral fat (especially in females), directly supporting waistline maintenance.
- Daily consumption of a synbiotic yogurt decreases energy intake but does not improve gastrointestinal transit time: a double-blind, randomized, crossover study in healthy adults
PubMed ID: 23787118
Synbiotic (inulin) group reduced energy intake acutely, which can support weight management over time.
- Improvement of fasting plasma glucose level after ingesting moderate amount of dietary fiber in Japanese men with mild hyperglycemia and visceral fat obesity
PubMed ID: 23725526
12-week RCT adding 7.5 g/day fiber produced modest, statistically significant reductions in body weight and BMI.
- Lifestyle intervention reduces body weight and improves cardiometabolic risk factors in worksites
PubMed ID: 23426035
Workplace program including high-fiber diet produced large weight loss across participants, consistent with a role for higher-fiber diets in weight management (multi-component).
- Infancy-onset dietary counseling of low-saturated-fat diet improves insulin sensitivity in healthy adolescents 15-20 years of age: the Special Turku Coronary Risk Factor Intervention Project (STRIP) study
PubMed ID: 23801725
Childhood counseling with higher-fiber intake produced modest persistent metabolic benefits and may support long-term weight control.
- Improvement of the metabolic syndrome profile by soluble fibre - guar gum - in patients with type 2 diabetes: a randomised clinical trial
PubMed ID: 23551992
Guar gum supplementation lowered waist circumference modestly over 4–6 weeks — direct RCT evidence supporting waistline benefit.
- A natural fiber complex reduces body weight in the overweight and obese: a double-blind, randomized, placebo-controlled study
PubMed ID: 23505169
Double‑blind RCT: standardized natural fiber complex produced significantly greater weight, fat mass and waist reductions vs placebo (strong RCT evidence).
- Satiety and energy intake after single and repeated exposure to gel-forming dietary fiber: post-ingestive effects
PubMed ID: 24030518
Acute reduction in intake after pectin suggests potential contribution to energy intake control and weight management.
- Soy fiber improves weight loss and lipid profile in overweight and obese adults: a randomized controlled trial
PubMed ID: 23881774
Soy‑fiber biscuits for 12 weeks led to more weight loss than controls (small RCT supportive).
- Low glycaemic index diets improve glucose tolerance and body weight in women with previous history of gestational diabetes: a six months randomized trial
PubMed ID: 23705645
Low‑GI advice (increasing fiber by ~4 g/day) produced modest weight loss over 6 months in women with prior gestational diabetes.
- Improvement effect of resistant maltodextrin in humans with metabolic syndrome by continuous administration
PubMed ID: 23419401
Resistant maltodextrin reduced visceral fat area over 12 weeks in metabolic‑syndrome subjects, supporting a role in body‑composition management.
- The effects of bulking, viscous and gel-forming dietary fibres on satiation
PubMed ID: 22850326
Acute reduction in energy intake (22%) with alginate-containing product indicates a plausible mechanism to aid weight control over time.
- Weight-loss diets modify glucose-dependent insulinotropic polypeptide receptor rs2287019 genotype effects on changes in body weight, fasting glucose, and insulin resistance: the Preventing Overweight Using Novel Dietary Strategies trial
PubMed ID: 22237064
In a large weight‑loss trial, a low‑fat/high‑fiber diet produced modest additional weight and metabolic benefits in genotype‑specific groups.
- Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial
PubMed ID: 22848584
Psyllium reduced android:gynoid fat ratio in adolescents, indicating a favorable effect on central adiposity (waistline proxy).
- Flaxseed dietary fiber supplements for suppression of appetite and food intake
PubMed ID: 22245724
Acute reduction in subsequent energy intake after soluble flax fiber supports short‑term appetite control relevant to weight management.
- Effect of alginate supplementation on weight loss in obese subjects completing a 12-wk energy-restricted diet: a randomized controlled trial
PubMed ID: 22648709
Alginate supplementation with calorie restriction produced greater weight and fat loss in completers (supports a role of fiber in weight management under some conditions).
- Randomized controlled trial of oatmeal consumption versus noodle consumption on blood lipids of urban Chinese adults with hypercholesterolemia
PubMed ID: 22866937
Oatmeal replacement lowered waist circumference over 6 weeks—direct evidence for waistline benefit.
- Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults
PubMed ID: 21414045
HVP fiber reduced hip circumference and produced modest weight loss—evidence supporting waistline/shape maintenance.
- Rye kernel breakfast increases satiety in the afternoon - an effect of food structure
PubMed ID: 21481225
Whole-grain rye produced greater satiety and may reduce intake across the day, a plausible contributor to weight management.
- Effects of NUTRIOSE® dietary fiber supplementation on body weight, body composition, energy intake, and hunger in overweight men
PubMed ID: 21591985
NUTRIOSE twice daily produced modest but statistically significant weight, BMI and body fat reductions over 12 weeks with lower energy intake—direct weight management evidence.
- The soluble fiber NUTRIOSE induces a dose-dependent beneficial impact on satiety over time in humans
PubMed ID: 22024490
Strong, dose-dependent satiety effects could support reduced intake/weight management over time (trial showed subjective effects; weight outcomes not primary).
- Randomized, controlled nutrition education trial promotes a Mediterranean diet and improves anthropometric, dietary, and metabolic parameters in adults
PubMed ID: 21736003
Mediterranean diet education increased fibre and produced significant weight loss and lower fasting insulin over 25 weeks—supports weight‑management role of fibre‑rich diets.
- Associations between snacking and weight loss and nutrient intake among postmenopausal overweight to obese women in a dietary weight-loss intervention
PubMed ID: 22117666
Snacking‑timing analysis within a weight‑loss program associated higher fibre intake with better weight loss outcomes (ancillary evidence).
- Dietary intakes associated with successful weight loss and maintenance during the Weight Loss Maintenance trial
PubMed ID: 22117658
Large weight‑loss program showed increases in fibre accompanied clinically meaningful weight loss and partial maintenance—strong pragmatic evidence.
- Dietary energy density and successful weight loss maintenance
PubMed ID: 21385641
Cross‑sectional data show long‑term weight‑loss maintainers report higher fibre intake—consistent association with weight control.
- Randomized controlled trial to improve adiposity, inflammation, and insulin resistance in obese African-American and Latino youth
PubMed ID: 21293446
Intervention reduced hepatic fat (with exercise) and improved insulin sensitivity—favors maintenance of healthy waistline.
- Comparison of high protein and high fiber weight-loss diets in women with risk factors for the metabolic syndrome: a randomized trial
PubMed ID: 21524314
Randomized trial showed high‑fiber diet increased fiber intake and contributed to weight/fat loss—direct human evidence supporting weight management.
- A pilot comprehensive lifestyle intervention program (CLIP)--comparison with qualitative lifestyle advice and simvastatin on cardiovascular risk factors in overweight hypercholesterolaemic individuals
PubMed ID: 20110160
Structured lifestyle/functional-foods program (including high-fiber foods) produced greater short-term weight and waist improvements vs advice (multicomponent but compatible with fiber benefit).
- Effect of weight loss intervention on the association between eating behaviour measured by TFEQ-18 and dietary intake in adults
PubMed ID: 20955744
Participants with higher fiber intake and cognitive restraint lost more weight over 18 months (associative evidence linking fiber intake to better weight outcomes).
- Short-term effects of a snack including dried prunes on energy intake and satiety in normal-weight individuals
PubMed ID: 20434071
Prune preload reduced subsequent caloric intake acutely — supports short‑term energy intake reduction that could aid weight management.
- The beneficial effects of α-cyclodextrin on blood lipids and weight loss in healthy humans
PubMed ID: 21127475
α‑Cyclodextrin produced a small but significant mean weight reduction (−0.4 kg) in a crossover trial — modest weight‑management signal.
- Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods
PubMed ID: 20102847
Oat cereal group lost significantly more waist circumference during a weight‑loss program vs control—direct evidence for waistline benefit.
- The effect of increasing consumption of pulses and wholegrains in obese people: a randomized controlled trial
PubMed ID: 21041811
Pulses/wholegrain intervention produced a slightly larger long-term waist reduction (−2.8 cm at 18 months) — direct evidence for waist maintenance.
- NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
PubMed ID: 21164548
NUTRIOSE RCT reduced body weight, fat and waist circumference versus placebo — direct support for waistline maintenance.
- Chickpea supplementation in an Australian diet affects food choice, satiety and bowel health
PubMed ID: 19945492
Chickpea supplementation raised fullness and lowered intake of some foods over 12 weeks — supportive real‑world evidence for weight management potential.
- A simple dietary message to improve dietary quality: Results from a pilot investigation
PubMed ID: 19359142
Pilot RCT: a simple high-fiber dietary message was associated with improved diet quality and modest weight loss—supports fiber's role in weight management.
- Viscosity of fiber preloads affects food intake in adolescents
PubMed ID: 19157816
Viscous fiber preload reduced subsequent intake (acute effect), which can support weight management if sustained.
- Sleep duration, lifestyle intervention, and incidence of type 2 diabetes in impaired glucose tolerance: The Finnish Diabetes Prevention Study
PubMed ID: 19651919
Lifestyle program including more fiber produced meaningful 1‑year weight loss in high‑risk individuals.
- Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk
PubMed ID: 19289389
Increased fiber intake in a large intervention associated with reductions in body weight and waist circumference.
- A low-fat vegan diet elicits greater macronutrient changes, but is comparable in adherence and acceptability, compared with a more conventional diabetes diet among individuals with type 2 diabetes
PubMed ID: 19167953
Randomized trial: low‑fat high‑fiber vegan diet produced substantial weight loss vs standard diabetes diet.
- Reduction in risk factors for type 2 diabetes mellitus in response to a low-sugar, high-fiber dietary intervention in overweight Latino adolescents
PubMed ID: 19349560
Adolescents increasing fiber lost visceral adipose tissue (~10%) and improved insulin response — supports waistline maintenance.
- A randomized behavioural trial targeting glycaemic index improves dietary, weight and metabolic outcomes in patients with type 2 diabetes
PubMed ID: 19161649
Program-increased fiber intake produced BMI reductions and improved glycaemia — supports role of fiber in weight control.
- High intake of fruits and vegetables predicts weight loss in Brazilian overweight adults
PubMed ID: 19083413
Behavioral intervention data showed increased fruit/vegetable (fiber-rich) intake was associated with modest but significant weight loss at 6 months.
- The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome
PubMed ID: 18175740
Whole‑grain consumption during calorie restriction produced greater reductions in abdominal percent body fat than refined grains — directly relevant to maintaining waistline.
- A low-energy-dense diet adding fruit reduces weight and energy intake in women
PubMed ID: 18439712
Replacing a snack with whole fruits led to reduced energy intake and modest weight loss vs oat cookie — supports use of fiber‑rich, low energy‑density foods for weight control.
- Use of cereal fiber to facilitate adherence to a human caloric restriction program
PubMed ID: 19179834
High‑fiber cereal users later showed better adherence to a 30% calorie restriction and greater satisfaction — plausible aid to weight management via adherence and satiety.
- Efficacy of lifestyle changes in modifying practical markers of wellness and aging
PubMed ID: 18383987
10‑week lifestyle program including added fiber resulted in a modest weight loss (−2.3 kg) though multiple components contributed.
- Beneficial effects of a diabetes specific formula on insulin sensitivity and free fatty acid in patients with type 2 diabetes mellitus
PubMed ID: 18701020
Improved insulin responses with the high‑fiber formula suggest a mechanism that could aid weight management; short duration limits direct weight evidence.
- Improvement of insulin resistance after diet with a whole-grain based dietary product: results of a randomized, controlled cross-over study in obese subjects with elevated fasting blood glucose
PubMed ID: 17562226
Whole‑grain (fiber‑rich) product produced modest weight improvements and metabolic benefits beyond weight loss.
- The benefits of early intervention in obese diabetic patients with FBCx: a new dietary fibre
PubMed ID: 17013969
The FBCx fiber product helped obese diabetic patients avoid weight gain vs placebo (randomized double‑blind trial).
- Effectiveness of a lifestyle intervention on metabolic syndrome. A randomized controlled trial
PubMed ID: 17922167
Lifestyle program that included increased fiber reduced obesity and incidence of diabetes at 1 year.
- Health Hunters--an intervention to prevent overweight and obesity in young high-risk women
PubMed ID: 16276359
Higher dietary fiber density was associated with protection for waist measures within a year-long prevention program (associative evidence).
- Long-term effects of popular dietary approaches on weight loss and features of insulin resistance
PubMed ID: 16158081
Diet trial data indicated the high-carbohydrate/high-fiber arm had modest benefits for some metabolic/waist measures vs other diets.
- Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study
PubMed ID: 17098085
Large lifestyle program increasing fiber was associated with substantial reduction in incident diabetes and sustained weight loss (multifactorial intervention).
- Lupin-enriched bread increases satiety and reduces energy intake acutely
PubMed ID: 17093146
Acute reductions in subsequent energy intake after lupin/bread tests support mechanisms that could aid weight control over time.
- High-fibre, low-fat diet predicts long-term weight loss and decreased type 2 diabetes risk: the Finnish Diabetes Prevention Study
PubMed ID: 16541277
High-fiber, low-fat diets predicted better long-term weight loss and waist circumference improvements in a diabetes prevention context.
- Comparison of 4 diets of varying glycemic load on weight loss and cardiovascular risk reduction in overweight and obese young adults: a randomized controlled trial
PubMed ID: 16864756
High‑fiber reduced‑fat diets produced the largest proportions of ≥5% weight loss in some diet arms, supporting a role for fiber-rich diets in weight management.
- The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon
PubMed ID: 15916709
Irvingia seed extract led to ~5% waist circumference reduction at 4 weeks, consistent with short-term waistline change.
- [Response to a weight control program based on approximating the diet to its theoretical ideal]
PubMed ID: 16335023
Randomized increase in breakfast cereals (higher fibre) produced modestly greater short-term weight loss.
- Beneficial effects of short-term nutritional counselling at the primary health-care level among Brazilian adults
PubMed ID: 16277797
Counselling that increased produce/fibre intake led to weight loss, though interventions were multifactorial.
- Experiences with three different fiber supplements in weight reduction
PubMed ID: 15614200
Multiple viscous fiber supplements added to a 1200 kcal diet produced clinically meaningful, consistent additional weight loss vs placebo.
- Effects of agar (kanten) diet on obese patients with impaired glucose tolerance and type 2 diabetes
PubMed ID: 15642074
Agar added to diet in obese/IGT or T2DM patients produced greater weight and BMI reductions vs conventional diet.
- Dietary fiber intake and risk factors for cardiovascular disease in French adults
PubMed ID: 16332650
Higher fiber intake associated with lower odds of overweight and lower waist-related measures in a large cross-sectional sample.
- Longitudinal changes in body weight and body composition among women previously treated for breast cancer consuming a high-vegetable, fruit and fiber, low-fat diet
PubMed ID: 15309460
Higher fruit/veg/fiber diet caused short-term weight and fat loss at 6 months (transient benefit).
- Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial
PubMed ID: 14744846
High-complex-carbohydrate/high-fibre ad libitum diet produced meaningful weight and fat loss in older adults (strong evidence).
- Supplementation of wheat fibre can improve risk profile in patients with dysmetabolic cardiovascular syndrome
PubMed ID: 15187818
Wheat fiber improved cardiometabolic markers and was associated with body composition improvements while on intervention (moderate support).
- Effects of a beverage containing an enzymatically induced-viscosity dietary fiber, with or without fructose, on the postprandial glycemic response to a high glycemic index food in humans
PubMed ID: 12947431
Guar gum improved postprandial glycemia and increases satiety—mechanistic links to supporting weight management (human trial; indirect weight endpoints).
- Dietary fibre intake and clinical indices in the French Supplementation en Vitamines et Minéraux AntioXydants (SU.VI.MAX) adult cohort
PubMed ID: 12740051
Higher habitual fiber associated with lower BMI in a large cohort — supportive observational evidence for waistline maintenance.
- Prevention of diabetes mellitus in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study: results from a randomized clinical trial
PubMed ID: 12819313
Intensive lifestyle counseling (including more fiber) produced meaningful weight loss, supporting waistline maintenance as part of the package.
- Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial
PubMed ID: 12684358
2-year lifestyle program (incl. more fiber) produced weight loss and lower inflammation.
- Effects of dietary intervention on IGF-I and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial
PubMed ID: 12947426
5-month dietary intervention with higher fiber associated with significant weight and waist reductions.
- The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity
PubMed ID: 14633807
Large intensive lifestyle program including increased fiber produced sustained weight loss over 3 years.
- Ready-to-eat cereal used as a meal replacement promotes weight loss in humans
PubMed ID: 12480804
Cereal meal-replacement substantially reduced caloric intake and produced short-term weight/fat loss — directly supportive of waistline maintenance when part of a controlled plan.
- Dietary counselling for dyslipidemia in primary care: results of a randomized trial
PubMed ID: 12493139
Psyllium-containing cereal or diet advice led to modest but meaningful weight loss (~1.9% over 6 months) versus control.
- Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
PubMed ID: 11333990
Multicomponent lifestyle program with increased fiber halved diabetes incidence and caused modest weight loss — strong overall weight-management evidence though fiber-specific contribution unclear.
- Long-term effect of fibre supplement and reduced energy intake on body weight and blood lipids in overweight subjects
PubMed ID: 11294130
Randomized double-blind fibre supplement plus low-calorie diet produced significantly greater weight loss than placebo — strong direct evidence for weight-management benefit when combined with calorie restriction.
- The Finnish Diabetes Prevention Study
PubMed ID: 10889804
Lifestyle program including increased fiber produced meaningful weight loss and cardiometabolic improvements that support maintaining waistline over time.
- Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme
PubMed ID: 10440120
Diet/exercise program including more fiber led to meaningful weight loss (~−4.7 kg), supporting weight management role.
- Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance
PubMed ID: 10447232
Intensive lifestyle program with a high‑fiber diet produced substantial weight loss (~−5.4 kg vs −0.5 kg); strong support though multi-component intervention.
- Intense nonpharmacological intervention in subjects with multiple cardiovascular risk factors: decreased fasting insulin levels but only a minor effect on plasma plasminogen activator inhibitor activity
PubMed ID: 9550533
Lifestyle program including high‑fibre diet lowered BMI — supports weight control though multifactorial.
- [Evaluation of the action of glucomannan on metabolic parameters and on the sensation of satiation in overweight and obese patients]
PubMed ID: 7796558
Adding glucomannan to a low-calorie diet produced better weight outcomes than diet alone (direct evidence for weight management).
- [Chronic use of glucomannan in the dietary treatment of severe obesity]
PubMed ID: 1313163
Adding glucomannan to a low-calorie diet enhanced fat loss and diet adherence in severely obese patients.
- Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of one year follow up
PubMed ID: 1586782
Post-MI cardioprotective diet including soluble fiber produced substantial weight loss (multifactorial but clinically important).
- Dietary modulators of lipid metabolism in the Indian diet-heart study (I.D.H.S.)
PubMed ID: 1316885
Dietary intervention including increased fiber was associated with favorable weight/lipid changes over 8 weeks.
- A dietary fibre supplement in the treatment of mild hypertension. A randomized, double-blind, placebo-controlled trial
PubMed ID: 1313484
Randomized double‑blind RCT of a fibre supplement reduced body weight in mildly hypertensive patients—direct evidence for weight management.
- Overweight treated with energy restriction and a dietary fibre supplement: a 6-month randomized, double-blind, placebo-controlled trial
PubMed ID: 2172178
Randomized DB trial: adding 7 g/day fibre to calorie‑restricted diet increased weight loss vs placebo (≈2.5 kg additional loss).
- The inclusion of a partial meal replacement with or without inulin to a calorie restricted diet contributes to reach recommended intakes of micronutrients and decrease plasma triglycerides: a randomized clinical trial in obese Mexican women
PubMed ID: 22703579
Inulin added to a low‑calorie diet aided triglyceride reduction and contributed to weight loss in obese women over 3 months → good support for weight management adjunct.
- Eating rate of commonly consumed foods promotes food and energy intake
PubMed ID: 21094194
Slower eating and lower intake with higher‑fibre foods provide indirect support for energy intake reduction relevant to weight control.
- Impact of some isoenergetic snacks on satiety and next meal intake in healthy adults
PubMed ID: 19743984
Acute trial showed fibre‑enriched product lowered next‑meal energy intake—supports short‑term mechanisms relevant to weight management.
- Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice
PubMed ID: 23207186
Short-term reduction in calorie intake (~80 kcal) with inulin suggests a plausible mechanism for supporting weight management over time.
- The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study
PubMed ID: 18377661
10‑week multi‑ingredient trial including Irvingia reported a 21% waist circumference reduction; fiber may have contributed but effect is not isolated to fiber.
- The effects of chitosan supplementation on anthropometric indicators of obesity, lipid and glycemic profiles, and appetite-regulated hormones in adolescents with overweight or obesity: a randomized, double-blind clinical trial
PubMed ID: 36064382
Chitosan produced a mean waist reduction of −5.00 ± 3.11 cm over 12 weeks in adolescents — direct waistline benefit.
- Single-blind, placebo controlled randomised clinical study of chitosan for body weight reduction
PubMed ID: 26747458
Randomized placebo-controlled oral chitosan produced ~3.1 kg weight loss over 90 days vs ~0.3 kg for placebo — robust effect within this dataset.
- Beneficial Effects of a Freeze-Dried Kale Bar on Type 2 Diabetes Patients: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
PubMed ID: 39519473
High‑fiber kale bars produced modest weight loss and reduced calorie intake in T2D patients — direct RCT evidence linking a fiber‑rich food to weight change.
- Comparing the Effects of Consuming Almonds or Biscuits on Body Weight in Habitual Snackers: A 1-Year Randomized Controlled Trial
PubMed ID: 37156442
One‑year almond snack substitution increased fiber/nutrients without weight gain — supports waistline maintenance with higher‑fiber snack choices.
- Nutritional quality of calorie restricted diets in the CALERIE™ 1 trial
PubMed ID: 35643360
Calorie-restriction intervention increased fiber intake and led to weight loss and improved diet quality—supportive of fiber's role within weight-management programs.
- Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis
PubMed ID: 29777234
Strong evidence that baseline microbiome (Prevotella-to-Bacteroides ratio) predicts substantially greater weight/fat loss on higher-fiber diets.
- The effect of daily fortified yogurt consumption on weight loss in adults with metabolic syndrome: A 10-week randomized controlled trial
PubMed ID: 29724529
Fortified yogurt group had greater waist circumference reduction versus plain yogurt, supporting a role for the product (which included prebiotic fiber) in waistline improvement.
- Improved nutrient intake in older obese adults undergoing a structured diet and exercise intentional weight loss program
PubMed ID: 20617289
Multi‑component weight‑loss program increased fiber intake and produced ~9% weight loss—fiber contributed within a complex program.
- Daily ingestion of alginate reduces energy intake in free-living subjects
PubMed ID: 18655817
Alginate preload reduced daily energy intake by ~135 kcal/day, a magnitude likely to support weight control if sustained.
- [The use of highly purified glucomannan-based fibers in childhood obesity]
PubMed ID: 1324483
Glucomannan added to diet in obese children associated with reductions in excess weight over ~4 months (nonrandomized evidence).
- Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity
PubMed ID: 40669445
Chicory root reduced triglycerides and altered adipocyte size distribution—metabolic changes that support waistline maintenance.
- The Effects of High Fiber Rye, Compared to Refined Wheat, on Gut Microbiota Composition, Plasma Short Chain Fatty Acids, and Implications for Weight Loss and Metabolic Risk Factors (the RyeWeight Study)
PubMed ID: 35458231
High-fiber rye was part of hypocaloric weight-loss intervention with supportive metabolic/SCFA changes linked to maintaining waistline improvements.
- Effects of high-fiber diets enriched with carbohydrate, protein, or unsaturated fat on circulating short chain fatty acids: results from the OmniHeart randomized trial
PubMed ID: 31927581
High-fiber diets produced SCFA changes associated with lower insulin/glucose—mechanisms relevant to weight control.
- Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake
PubMed ID: 32075887
Mediterranean pattern (higher fibre) improved metabolic markers and microbiome, supporting long-term body composition maintenance.
- Modulation of amino acid metabolic signatures by supplemented isoenergetic diets differing in protein and cereal fiber content
PubMed ID: 25157543
Cereal-fiber–induced metabolic improvements (IR) could support weight management mechanisms.
- Effect of Walnut Predinner Snack on Mealtime Hunger and Nutrient Intake Among University Students
PubMed ID: 34714144
Acute reduction (~9%) in meal calories after a walnut snack supports short-term energy intake control.
- Added soluble fiber enhances the satiating power of low-energy-density liquid yogurts
PubMed ID: 19857627
Reduced subsequent energy intake after inulin suggests potential for weight-management support.
- Role of a prudent breakfast in improving cardiometabolic risk factors in subjects with hypercholesterolemia: a randomized controlled trial
PubMed ID: 24814382
Three months of a fibre‑rich prudent breakfast reduced sagittal abdominal diameter (a visceral fat marker), supporting maintenance of waistline.
- Metabolite Biomarkers Linking a High-Fiber Rye Intervention with Cardiometabolic Risk Factors: The RyeWeight Study
PubMed ID: 40838659
High‑fiber rye intervention produced greater weight and fat‑mass loss versus refined wheat in a large RCT.
- Instant Oatmeal Increases Satiety and Reduces Energy Intake Compared to a Ready-to-Eat Oat-Based Breakfast Cereal: A Randomized Crossover Trial
PubMed ID: 26273900
Immediate ~85 kcal reduction at the next meal could accumulate to support weight control over time.
- Enrichment of biscuits and juice with oat β-glucan enhances postprandial satiety
PubMed ID: 24434584
Increased satiety with higher β‑glucan doses supports intake reduction potential relevant to weight management.
- Changes in nutrient intake and dietary quality among participants with type 2 diabetes following a low-fat vegan diet or a conventional diabetes diet for 22 weeks
PubMed ID: 18926128
Diabetic patients on low‑fat vegan diet ate more fiber and improved diet quality — relevant to weight management.
- Addition of Rye Bran and Pea Fiber to Pork Meatballs Enhances Subjective Satiety in Healthy Men, but Does Not Change Glycemic or Hormonal Responses: A Randomized Crossover Meal Test Study
PubMed ID: 28794212
Fiber increased satiety but did not lower immediate ad‑libitum intake in the trial—plausible modest contribution to weight control over time.
- Differential Effects of Red Meat/Refined Grain Diet and Dairy/Chicken/Nuts/Whole Grain Diet on Glucose, Insulin and Triglyceride in a Randomized Crossover Study
PubMed ID: 27809219
Dietary pattern differences that include higher‑quality fiber produced better postprandial metabolic responses linked to weight regulation (indirect evidence).
- Barley-Based Cereals Enhance Metabolic Health and Satiety in Overweight Korean Adults: A Randomized Trial
PubMed ID: 40944189
6‑week barley cereal reduced waist circumference significantly in overweight adults—direct evidence for waistline maintenance/reduction.
- Effects of high β-glucan barley on visceral fat obesity in Japanese individuals: A randomized, double-blind study
PubMed ID: 28870472
High β‑glucan barley substitution modestly reduced visceral fat and body weight (supports waist management over time).
- Avocado Consumption, Abdominal Adiposity, and Oral Glucose Tolerance Among Persons with Overweight and Obesity
PubMed ID: 34191028
Daily avocado meal modestly improved visceral:subcutaneous fat ratio in women over 12 weeks—relevant to waistline maintenance.
- Effect of flaxseed consumption on central obesity, serum lipids, and adiponectin level in overweight or obese women: A randomised controlled clinical trial
PubMed ID: 34227198
Milled flaxseed over 12 weeks reduced waist circumference and waist-to-hip ratio in overweight women.
- The Impact of Glucomannan, Inulin, and Psyllium Supplementation (Soloways(TM)) on Weight Loss in Adults with FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 38398881
Strong, well-powered 6‑month RCT: combined fibers produced clinically meaningful weight, BMI and fat‑mass loss vs placebo.
- Gene-diet interaction in response to defatted flaxseed flour supplementation on obesity-related traits in Chinese overweight and obese adults: A randomized controlled trial
PubMed ID: 36368262
Small RCT: flaxseed-flour biscuits led to genotype-dependent weight and BMI reductions in overweight/obese adults.
- Rapid benefits in older age from transition to whole food diet regardless of protein source or fat to carbohydrate ratio: Arandomised control trial
PubMed ID: 39011855
Switching to a provided whole-food diet that markedly increased fiber produced modest but significant weight loss in older adults, supporting fiber's role in weight management within a dietary pattern.
- Decreases in dietary glycemic index are related to weight loss among individuals following therapeutic diets for type 2 diabetes
PubMed ID: 21653575
Lower dietary GI (which can reflect increased fiber) was associated with modest additional weight loss in type 2 diabetes; effect mediated weight-related A1c benefit.
- Effects of a healthy Nordic diet on cardiovascular risk factors in hypercholesterolaemic subjects: a randomized controlled trial (NORDIET)
PubMed ID: 20964740
Nordic diet produced a modest ~4% body‑weight reduction in a randomized trial that included increased plant/fiber foods, supporting benefit for waistline maintenance (multi‑component).
- Metabolomic analysis of plasma metabolites that may mediate effects of rye bread on satiety and weight maintenance in postmenopausal women
PubMed ID: 21084654
Metabolic signals changed by high‑fiber rye bread are linked to satiety/weight maintenance in postmenopausal women.
- The effect of chitosan supplementation on liver function, hepatic steatosis predictors, and metabolic indicators in adults with non-alcoholic fatty liver disease: a randomized, double-blinded, placebo-controlled, clinical trial
PubMed ID: 40025618
Chitosan plus calorie reduction produced a modest but significant waist circumference reduction (−1.81 cm), directly supporting waistline maintenance/ reduction.
- Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
PubMed ID: 35300378
High‑quality randomized konjac trial produced large, significant reductions in BMI and fat mass—strong direct evidence that this fiber aids weight loss.
- Impact of a low-carbohydrate and high-fiber diet on nonalcoholic fatty liver disease
PubMed ID: 32990607
High‑fiber component of intervention in NAFLD improved visceral fat and waist measures over 2 months.
- A new dietary strategy for long-term treatment of the metabolic syndrome is compared with the American Heart Association (AHA) guidelines: the MEtabolic Syndrome REduction in NAvarra (RESMENA) project
PubMed ID: 23968597
RESMENA diet (higher fiber) significantly reduced waist circumference and android fat mass; fiber implicated as main contributor.
- Intake of brown rice lees reduces waist circumference and improves metabolic parameters in type 2 diabetes
PubMed ID: 21419317
Brown‑rice lees supplement reduced waist circumference in T2D patients—consistent with fiber/whole‑grain effects on central adiposity.
- Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial
PubMed ID: 30420171
Higher Akkermansia muciniphila associated with lower fat mass and correlated with fiber intake—associative support for waistline effects of fiber via microbiota.
- Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects
PubMed ID: 33672963
Satiety increases and trending lower intake with acacia gum suggest potential help in weight control.
- Effect of Gum Arabic (Acacia Senegal) supplementation on visceral adiposity index (VAI) and blood pressure in patients with type 2 diabetes mellitus as indicators of cardiovascular disease (CVD): a randomized and placebo-controlled clinical trial
PubMed ID: 29558953
Gum arabic reduced visceral adiposity indexes and modestly lowered weight/BMI in T2D, supporting waistline maintenance.
Blood sugar (203)
- Longitudinal associations of dietary fiber and its source with 48-week weight loss maintenance, cardiometabolic risk factors and glycemic status under metformin or acarbose treatment: a secondary analysis of the March randomized trial
PubMed ID: 39358341
Large analysis: higher total/whole‑grain/legume fiber associated with better postprandial glucose control and improved β‑cell function.
- Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial
PubMed ID: 15383514
Mediterranean‑style diet improved insulin sensitivity (reduced insulin resistance) over 2 years—dietary fiber increase likely contributed but effects are from a multi‑component dietary change.
- Avocado Fruit on Postprandial Markers of Cardio-Metabolic Risk: A Randomized Controlled Dose Response Trial in Overweight and Obese Men and Women
PubMed ID: 30213052
Replacing carbs with avocado lowered postprandial glucose/insulin—avocado contains fiber which likely contributed to steadier glycemia.
- Alternative Foods in Cardio-Healthy Dietary Models That Improve Postprandial Lipemia and Insulinemia in Obese People
PubMed ID: 34209561
Fiber‑rich FAWGT diet reduced acute and chronic postprandial insulin responses and improved HOMA‑IR.
- Barley cultivar, kernel composition, and processing affect the glycemic index
PubMed ID: 22833662
Demonstrated that barley cultivar/processing and higher total fiber correlate strongly with lower GI (r = -0.75).
- Efficacy of fibre additions to flatbread flour mixes for reducing post-meal glucose and insulin responses in healthy Indian subjects
PubMed ID: 28260548
Chickpea flour + guar gum flatbreads caused substantial acute reductions in postprandial glucose and insulin in 56 adults.
- Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics
PubMed ID: 30046942
Barley kernel bread improved postprandial glucose tolerance and lowered insulin AUC across subgroups—clinical human evidence.
- Effect of Barley on Postprandial Blood Glucose Response and Appetite in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39599684
Barley fiber drink markedly reduced postprandial glucose and insulin spikes in healthy adults (double‑blind crossover).
- Differential Effects of Red Meat/Refined Grain Diet and Dairy/Chicken/Nuts/Whole Grain Diet on Glucose, Insulin and Triglyceride in a Randomized Crossover Study
PubMed ID: 27809219
Wholegrain/nuts/dairy pattern (higher fiber quality) produced much lower postprandial insulin and glucose vs red‑meat/refined pattern.
- Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial
PubMed ID: 11829698
Mediterranean‑type, fiber‑rich diet lowered fasting insulin ~14% — supports improved glycemic control/steadier sugars.
- Changes in nutrient intake and dietary quality among participants with type 2 diabetes following a low-fat vegan diet or a conventional diabetes diet for 22 weeks
PubMed ID: 18926128
Low‑fat vegan diet in T2D patients increased fiber and improved diet quality — relevant to glycemic control.
- Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure
PubMed ID: 17151592
β‑glucan foods reduced peak and incremental insulin AUC—consistent with improved postprandial glycemic control.
- The consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes
PubMed ID: 19230737
3 g/day β‑glucan improved insulin resistance (HOMA‑IR) and lowered fasting lipids in T2D—metabolic glycaemic benefit.
- Effect of adding oat bran to instant oatmeal on glycaemic response in humans - a study to establish the minimum effective dose of oat β-glucan
PubMed ID: 29480316
Dose‑dependent oat β‑glucan reduced 2‑h glucose iAUC and peak rise; minimal effective gram quantified.
- Postprandial Glycemic and Insulinemic Response by a Brewer's Spent Grain Extract-Based Food Supplement in Subjects with Slightly Impaired Glucose Tolerance: A Monocentric, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 36235569
Brewer’s‑spent‑grain extract lowered late postprandial glucose and decreased insulin AUC (~20%).
- Diets rich in whole grains increase betainized compounds associated with glucose metabolism
PubMed ID: 30256894
Whole‑grain/bran biomarkers inversely correlated with postprandial glucose/insulin in humans.
- Addition of Orange Pomace to Orange Juice Attenuates the Increases in Peak Glucose and Insulin Concentrations after Sequential Meal Ingestion in Men with Elevated Cardiometabolic Risk
PubMed ID: 27170728
Orange pomace fiber significantly lowered and delayed postprandial glucose and insulin peaks in at‑risk men.
- Orange Pomace Improves Postprandial Glycemic Responses: An Acute, Randomized, Placebo-Controlled, Double-Blind, Crossover Trial in Overweight Men
PubMed ID: 28208806
High‑fiber orange pomace beverage reduced post-meal glucose values and insulin AUC in overweight men.
- Addition of Orange Pomace Attenuates the Acute Glycemic Response to Orange Juice in Healthy Adults
PubMed ID: 33704466
OPF blunted peak glucose similar to whole fruit across small trials (consistent peak reduction).
- Modulation of amino acid metabolic signatures by supplemented isoenergetic diets differing in protein and cereal fiber content
PubMed ID: 25157543
Cereal‑fiber alterations substantially explained changes in whole-body and hepatic insulin resistance over 18 weeks.
- Effects of whole-grain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome
PubMed ID: 26706023
Whole‑grain cereal increased fasting propionate and responders had lower postprandial insulin—supporting steadier glycemia.
- Impact of rye-based evening meals on cognitive functions, mood and cardiometabolic risk factors: a randomized controlled study in healthy middle-aged subjects
PubMed ID: 30400947
Rye evening meals improved next-morning insulin sensitivity (ISI_composite +11%) in middle-aged adults—evidence of improved glycemic handling.
- Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake
PubMed ID: 32075887
Mediterranean pattern (more fiber) produced favorable metabolic shifts; may contribute to steadier blood sugar.
- Effects of high-fiber diets enriched with carbohydrate, protein, or unsaturated fat on circulating short chain fatty acids: results from the OmniHeart randomized trial
PubMed ID: 31927581
High-fiber diets altered circulating SCFAs linked to lower insulin/glucose—supports steadier glycemia over days/weeks.
- A microbiome-targeting fibre-enriched nutritional formula is well tolerated and improves quality of life and haemoglobin A1c in type 2 diabetes: A double-blind, randomized, placebo-controlled trial
PubMed ID: 36594522
Microbiome‑targeting fiber formula produced a clinically meaningful HbA1c reduction (−0.64%) in type 2 diabetes (strong evidence for steadier glycaemia).
- Impact of Combined Prebiotic Galacto-Oligosaccharides and Bifidobacterium breve-Derived Postbiotic on Gut Microbiota and HbA1c in Prediabetic Adults: A Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 39064648
Soluble‑fiber/prebiotic supplement in prediabetes lowered HbA1c (−0.38pp) and fasting glucose (−0.55 mmol/L) (direct glycaemic improvements).
- Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity
PubMed ID: 40669445
Chicory root improved peripheral insulin sensitivity and increased butyrate—supports improved glycaemic control.
- Improvement of dietary quality with the aid of a low glycemic index diet in Asian patients with type 2 diabetes mellitus
PubMed ID: 20833988
Low‑GI counseling that raised fiber intake produced clinically meaningful HbA1c reductions in the lowest GI/GL quartile.
- Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis
PubMed ID: 29777234
Greater weight/fat loss on higher-fiber diets can translate into better glycemic control for responders, supported by microbiome interaction data.
- Beneficial Effects of a Freeze-Dried Kale Bar on Type 2 Diabetes Patients: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
PubMed ID: 39519473
Kale bars improved HbA1c and HOMA‑IR over 12 weeks in T2D — clinical evidence that a fiber‑rich whole food intervention improved glycemic control.
- [Glycemic and insulin indices of tube feeding formulas in healthy adults]
PubMed ID: 17914545
Acute study: enteral formulas containing fiber showed lower postprandial glycemic responses vs a standard meal in healthy adults.
- Co-administration of viscous fiber, Salba-chia and ginseng on glycemic management in type 2 diabetes: a double-blind randomized controlled trial
PubMed ID: 33486572
24-week RCT with viscous fiber plus chia/ginseng modestly but significantly reduced HbA1c in people with type 2 diabetes.
- Single-blind, placebo controlled randomised clinical study of chitosan for body weight reduction
PubMed ID: 26747458
Chitosan reduced HbA1c (~−0.51%) in a higher-baseline subgroup, indicating some glycemic benefit in that subgroup.
- Gastrointestinal Tolerability and Acute Glycemic Response of Oligosaccharides and Polysaccharides from Cellulose and Xylan in Healthy Adults: Two Double-Blinded, Randomized, Controlled, Cross-over Trials
PubMed ID: 38032277
Two randomized crossover trials showed the plant‑fiber extract produced much smaller postprandial glycemic and insulinemic responses vs controls.
- Improvements in Glycemic, Micronutrient, and Mineral Indices in Arab Adults with Pre-Diabetes Post-Lifestyle Modification Program
PubMed ID: 31731609
Lifestyle program that raised fiber intake improved fasting glucose and HbA1c in adults with prediabetes—direct human evidence (multi-component).
- [Experience with an enteral diet with fiber and a high fat content in ICU patients with glucose intolerance]
PubMed ID: 1327177
High‑fat/high‑fiber enteral diet lowered glycemia and insulin needs in ICU patients, showing fibre-containing enteral feeds can blunt glycemia (context-specific).
- Influence of two guar preparations on glycosylated hemoglobin, total cholesterol and triglycerides in patients with diabetes mellitus
PubMed ID: 1335441
Guar fibre preparations in diabetics produced substantial reductions in glycosylated hemoglobin over 12 weeks—strong evidence of improved glycemic control.
- Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of one year follow up
PubMed ID: 1586782
Comprehensive cardioprotective dietary changes including soluble fiber improved metabolic markers; glucose effects plausible though not isolated to fiber.
- [Chronic use of glucomannan in the dietary treatment of severe obesity]
PubMed ID: 1313163
Glucomannan improved carbohydrate tolerance/glucose tolerance in obese patients — supports blood-sugar stabilization.
- Long-term comparison of three dietary prescriptions in the treatment of NIDDM
PubMed ID: 8112194
Long (18-month) diet interventions that included high-fiber options produced improved HbA1 in type 2 diabetes cohort.
- [Evaluation of the action of glucomannan on metabolic parameters and on the sensation of satiation in overweight and obese patients]
PubMed ID: 7796558
Glucomannan added to diet improved blood-glucose outcomes in the study population.
- Lipid- and glucose-lowering efficacy of Plantago Psyllium in type II diabetes
PubMed ID: 9747644
Regular psyllium supplementation lowered fasting plasma glucose in T2D patients in an RCT—good evidence for steadier glycemia.
- Intense nonpharmacological intervention in subjects with multiple cardiovascular risk factors: decreased fasting insulin levels but only a minor effect on plasma plasminogen activator inhibitor activity
PubMed ID: 9550533
Intensive lifestyle (high‑fiber included) reduced fasting insulin — supports improved glycaemic/metabolic control, though multifactorial.
- Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia
PubMed ID: 10500014
Psyllium lowered all-day and postlunch postprandial glucose in men with T2D.
- Efficacy and safety of acarbose in the treatment of Type 1 diabetes mellitus: a placebo-controlled, double-blind, multicentre study
PubMed ID: 10227568
Acarbose (slows carbohydrate absorption similar to viscous fiber) reduced postprandial glucose substantially in T1D—drug mechanistically relevant to how fiber can blunt postprandial spikes, though not a fiber trial.
- Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme
PubMed ID: 10440120
Program including increased fiber produced lower fasting and 2‑hr glucose at 1 year—direct evidence of improved glycemia in a multi-component trial.
- The Finnish Diabetes Prevention Study
PubMed ID: 10889804
Lifestyle program including high fiber improved glucose tolerance markers in people with impaired glucose tolerance (multicomponent).
- Long-term dietary treatment with increased amounts of fiber-rich low-glycemic index natural foods improves blood glucose control and reduces the number of hypoglycemic events in type 1 diabetic patients
PubMed ID: 11023137
Long‑term high‑fiber natural‑food diet in type 1 diabetics improved mean daily glucose and HbA1c and reduced hypoglycemic events.
- Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
PubMed ID: 11333990
Lifestyle program (weight loss, reduced fat, increased fibre and activity) halved diabetes incidence — strong evidence of improved glycaemic control as a program outcome (fiber one component).
- Consumption of whole grain and legume powder reduces insulin demand, lipid peroxidation, and plasma homocysteine concentrations in patients with coronary artery disease: randomized controlled clinical trial
PubMed ID: 11742886
Replacing refined rice with whole-grain/legume powder (higher fiber) substantially lowered fasting glucose and insulin and decreased glucose/insulin AUCs.
- Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control?
PubMed ID: 11978259
Whole-grain oat cereal reduced glucose as well as lipids and decreased antihypertensive medication—supports improved glycemic control linked to oat fibre.
- The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity
PubMed ID: 14633807
Intensive lifestyle increased fiber intake and produced better glycemic measures over time.
- Effects of dietary intervention on IGF-I and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial
PubMed ID: 12947426
Diet with higher fiber/less refined carbs reduced insulin-related markers and improved glucose responses.
- Prevention of diabetes mellitus in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study: results from a randomized clinical trial
PubMed ID: 12819313
Lifestyle program including higher fiber substantially reduced diabetes incidence — multifactorial but consistent with glycemic benefit.
- A flexible, low-glycemic index mexican-style diet in overweight and obese subjects with type 2 diabetes improves metabolic parameters during a 6-week treatment period
PubMed ID: 12832297
Low‑GI (higher‑fiber) diet improved A1c in type 2 diabetics over 6 weeks — clinically meaningful glycemic stability.
- Effects of a beverage containing an enzymatically induced-viscosity dietary fiber, with or without fructose, on the postprandial glycemic response to a high glycemic index food in humans
PubMed ID: 12947431
Direct human evidence: a viscosity-forming guar beverage (5 g) significantly reduced peak post-meal glucose and incremental AUC versus control.
- Effect of soluble fiber intake in lipid and glucose levels in healthy subjects: a randomized clinical trial
PubMed ID: 15163472
Increased soluble fiber lowered fasting glucose ~12% in healthy subjects (direct glycemic benefit).
- Supplementation of wheat fibre can improve risk profile in patients with dysmetabolic cardiovascular syndrome
PubMed ID: 15187818
Wheat-fiber supplementation improved fasting and 2-h glucose in metabolic-risk patients (supports glycemic steadiness).
- Inclusion of guar gum and alginate into a crispy bar improves postprandial glycemia in humans
PubMed ID: 15051842
Randomized crossover trial: guar gum + alginate reduced peak glucose by ~30% and AUC by ~33%—strong evidence for postprandial glycaemic attenuation.
- Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals
PubMed ID: 15158296
10.6 g/day scFOS lowered postprandial insulin incremental area (~18%) in mildly hypercholesterolaemic adults—direct glycaemic/insulin effect.
- Psyllium decreased serum glucose and glycosylated hemoglobin significantly in diabetic outpatients
PubMed ID: 16154305
Placebo-controlled trial: psyllium 5.1 g twice daily significantly lowered fasting glucose and HbA1c in type 2 diabetes—strong direct evidence.
- Effects of flax fiber on laxation and glycemic response in healthy volunteers
PubMed ID: 16379563
Flax fiber modestly lowered peak glucose and glucose AUC after bread (direct glycemic stabilization evidence).
- Effects of breakfast meal composition on second meal metabolic responses in adults with Type 2 diabetes mellitus
PubMed ID: 16670695
Psyllium-containing low-glycemic breakfast significantly reduced post-breakfast glucose and insulin AUC in adults with T2D.
- Effect of a viscous fiber bar on postprandial glycemia in subjects with type 2 diabetes
PubMed ID: 17031010
Viscous fiber significantly lowered postprandial glucose and insulin AUC in type 2 diabetes (robust randomized crossover data).
- Effectiveness of a lifestyle intervention on metabolic syndrome. A randomized controlled trial
PubMed ID: 17922167
Lifestyle program with increased fiber reduced diabetes incidence over 1 year.
- Improvement of insulin resistance after diet with a whole-grain based dietary product: results of a randomized, controlled cross-over study in obese subjects with elevated fasting blood glucose
PubMed ID: 17562226
Whole‑grain, reduced‑starch product improved fasting insulin and HOMA‑IR beyond weight loss—evidence for improved glycemic regulation.
- Hydroxypropylmethylcellulose and methylcellulose consumption reduce postprandial insulinemia in overweight and obese men and women
PubMed ID: 18203894
Viscous modified-cellulose fibers dose-dependently lowered insulin IAUC and modestly lowered peak glucose—strong evidence for steadier glycemia.
- Diet or exercise: what is more effective in preventing or reducing metabolic alterations?
PubMed ID: 18772269
Large lifestyle trial found an inverse association between fiber intake and fasting glucose (small but significant), supporting improved glycemic control.
- Beneficial effects of a diabetes specific formula on insulin sensitivity and free fatty acid in patients with type 2 diabetes mellitus
PubMed ID: 18701020
Strong RCT evidence: a high‑multi‑fiber diabetes formula markedly lowered postprandial glucose and insulin and improved insulin sensitivity over the short feeding period.
- A randomized behavioural trial targeting glycaemic index improves dietary, weight and metabolic outcomes in patients with type 2 diabetes
PubMed ID: 19161649
Behavioral increase in fiber decreased fasting and postprandial glucose in adults with type 2 diabetes — direct evidence of steadier glycaemia.
- Reduction in risk factors for type 2 diabetes mellitus in response to a low-sugar, high-fiber dietary intervention in overweight Latino adolescents
PubMed ID: 19349560
Adolescents increasing fibre had markedly lower insulin IAUC and improved glucose IAUC — metabolic evidence for steadier blood sugar.
- A low-fat vegan diet elicits greater macronutrient changes, but is comparable in adherence and acceptability, compared with a more conventional diabetes diet among individuals with type 2 diabetes
PubMed ID: 19167953
High‑fiber vegan diet delivered large HbA1c improvement (−1.23% vs −0.38%), clear evidence of improved glycaemic control.
- Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors: a 12-month randomized controlled weight loss trial
PubMed ID: 20938438
Lupin-enriched high-fiber/protein foods improved fasting insulin and HOMA — moderate support for better glycaemic control.
- NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
PubMed ID: 21164548
NUTRIOSE RCT improved insulin resistance, glucose markers and HbA1c — strong evidence for steadier blood sugar.
- The relation of low glycaemic index fruit consumption to glycaemic control and risk factors for coronary heart disease in type 2 diabetes
PubMed ID: 20978741
Increased low‑GI fruit intake (higher fiber) associated with modest HbA1c improvements in people with T2DM (observational evidence).
- Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial
PubMed ID: 20413122
Psyllium produced a modest reduction in insulin in hypercholesterolaemic adults—some support for glycemic/metabolic stabilization.
- Comparison of high protein and high fiber weight-loss diets in women with risk factors for the metabolic syndrome: a randomized trial
PubMed ID: 21524314
High‑fiber diet improved metabolic markers (insulin sensitivity measures) vs baseline—consistent with steadier glycaemia.
- Randomized controlled trial to improve adiposity, inflammation, and insulin resistance in obese African-American and Latino youth
PubMed ID: 21293446
16‑week program (reduce sugar, increase fiber) significantly improved insulin sensitivity in minority youth—robust clinical effect on glycemic control.
- Randomized, controlled nutrition education trial promotes a Mediterranean diet and improves anthropometric, dietary, and metabolic parameters in adults
PubMed ID: 21736003
Mediterranean education raised fibre and lowered fasting insulin, indicating improved glycaemic control/metabolic steadiness.
- Lower postprandial glucose responses at baseline and after 4 weeks use of a diabetes-specific formula in diabetes type 2 patients
PubMed ID: 21680040
Diabetes-specific (fiber-containing) formula produced lower post-meal glucose responses at baseline and after 4 weeks — direct clinical evidence of improved postprandial glycemia.
- Effects of supplemented isoenergetic diets differing in cereal fiber and protein content on insulin sensitivity in overweight humans
PubMed ID: 21633074
Cereal-fiber diet improved whole-body insulin sensitivity by ~25% vs high-protein at 6 weeks — supports better glycemic control.
- Effect of legumes as part of a low glycemic index diet on glycemic control and cardiovascular risk factors in type 2 diabetes mellitus: a randomized controlled trial
PubMed ID: 23089999
Adding legumes (high‑fiber, low‑GI) produced a clinically meaningful HbA1c reduction—direct evidence for steadier blood glucose.
- [Importance of nutritional counseling and dietary fiber content on glycemic control in type 2 diabetic patients under intensive educational intervention]
PubMed ID: 22584564
Intensive counseling raising fiber intake produced much better short-term glycemic control in T2D and fiber change correlated with mean glucose—strong indirect evidence.
- Dietary associations with prediabetic states--the DR's EXTRA Study (ISRCTN45977199)
PubMed ID: 22415336
Large observational study: higher dietary/cereal fiber linked to lower odds of impaired glucose tolerance—supports blood sugar regulation.
- Weight-loss diets modify glucose-dependent insulinotropic polypeptide receptor rs2287019 genotype effects on changes in body weight, fasting glucose, and insulin resistance: the Preventing Overweight Using Novel Dietary Strategies trial
PubMed ID: 22237064
High‑fiber dietary pattern in a weight‑loss trial led to significant fasting glucose and insulin improvements in a genetic subgroup.
- Improvement effect of resistant maltodextrin in humans with metabolic syndrome by continuous administration
PubMed ID: 23419401
Resistant maltodextrin significantly reduced fasting blood glucose in people with metabolic syndrome—direct evidence for improved glycemic control.
- Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial
PubMed ID: 24332524
Oligofructose-enriched inulin for 8 weeks significantly lowered fasting glucose and HbA1c in women with T2D — strong direct evidence for glycemic benefits.
- Low glycaemic index diets improve glucose tolerance and body weight in women with previous history of gestational diabetes: a six months randomized trial
PubMed ID: 23705645
Low‑GI dietary advice (with modest fiber increase) lowered 2‑hour postload glucose over 6 months.
- Improvement of the metabolic syndrome profile by soluble fibre - guar gum - in patients with type 2 diabetes: a randomised clinical trial
PubMed ID: 23551992
Guar gum RCT in T2D produced modest but consistent HbA1c reductions — good human evidence for improved glycaemic control.
- A CHO/fibre diet reduces and a MUFA diet increases postprandial lipaemia in type 2 diabetes: no supplementary effects of low-volume physical training
PubMed ID: 24132660
Isoenergetic carbohydrate+fiber diet lowered postprandial triglyceride-rich lipoproteins and improved postprandial metabolic profile in T2D — supports glycemic/metabolic steadiness.
- Infancy-onset dietary counseling of low-saturated-fat diet improves insulin sensitivity in healthy adolescents 15-20 years of age: the Special Turku Coronary Risk Factor Intervention Project (STRIP) study
PubMed ID: 23801725
Long-term dietary counseling raising fiber (among other changes) led to modest improvements in HOMA-IR and fasting insulin — supports better glycemic control.
- Improvement of fasting plasma glucose level after ingesting moderate amount of dietary fiber in Japanese men with mild hyperglycemia and visceral fat obesity
PubMed ID: 23725526
Daily added fiber (7.5 g) lowered fasting plasma glucose over 12 weeks in mildly hyperglycemic subjects (robust RCT finding).
- Endogenous plasma glucagon-like peptide-1 following acute dietary fibre consumption
PubMed ID: 23507477
Single‑day resistant starch lowered post‑lunch insulin (acute effect), suggesting some glycemic/insulin modulation.
- The effects of functional fiber on postprandial glycemia, energy intake, satiety, palatability and gastrointestinal wellbeing: a randomized crossover trial
PubMed ID: 25066659
Functional fibers in bread substantially reduced postprandial glucose iAUC and peak glucose (strong acute glycemic evidence).
- Regular breakfast consumption and type 2 diabetes risk markers in 9- to 10-year-old children in the child heart and health study in England (CHASE): a cross-sectional analysis
PubMed ID: 25181492
High-fiber cereal breakfasts associated with lower insulin resistance in children (observational but sizable association).
- An enriched, cereal-based bread affects appetite ratings and glycemic, insulinemic, and gastrointestinal hormone responses in healthy adults in a randomized, controlled trial
PubMed ID: 25644342
Fiber+protein cereal bread reduced postprandial glucose and insulin AUCs vs white bread (acute glycemic benefit).
- Taking a low glycemic index multi-nutrient supplement as breakfast improves glycemic control in patients with type 2 diabetes mellitus: a randomized controlled trial
PubMed ID: 25514391
Low‑GI, higher‑fiber breakfast replacement improved HbA1c and fasting glycemia over 12 weeks in T2D patients.
- Intensive low-glycaemic-load dietary intervention for the management of glycaemia and serum lipids among women with gestational diabetes: a randomized control trial
PubMed ID: 25222105
Low‑GL/higher‑fiber diet produced meaningful improvements in fasting and postprandial glucose in gestational diabetes.
- The impact of soluble dietary fibre on gastric emptying, postprandial blood glucose and insulin in patients with type 2 diabetes
PubMed ID: 24901089
Clear randomized crossover evidence in T2D: 7.5 g oat β‑glucan delayed gastric emptying and significantly lowered postprandial glucose and insulin.
- Effect of two dietary fibers on satiety and glycemic parameters: a randomized, double-blind, placebo-controlled, exploratory study
PubMed ID: 24886409
Oligofructose+pectin lowered glucose AUC and improved insulin sensitivity indices modestly over 3 weeks.
- Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity
PubMed ID: 24997634
Higher-fiber Mediterranean diet improved glucose measures in obese children over 16 weeks.
- A whole-grain cereal-based diet lowers postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome
PubMed ID: 24598599
Whole‑grain cereal diet significantly reduced postprandial insulin (and triglycerides) in metabolic‑syndrome participants—direct evidence for steadier insulin responses.
- Diet, insulin secretion and insulin sensitivity--the Dose-Responses to Exercise Training (DR's EXTRA) Study (ISRCTN45977199)
PubMed ID: 25230681
Observational associations show higher fiber/whole‑grain intake linked to better insulin sensitivity in older adults.
- Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study
PubMed ID: 24549027
Higher whole‑grain rye biomarker (proxy for fiber) inversely associated with fasting insulin and positively with insulin sensitivity indices in humans with metabolic syndrome.
- Wine grape pomace flour improves blood pressure, fasting glucose and protein damage in humans: a randomized controlled trial
PubMed ID: 26337448
Grape pomace fiber modestly lowered fasting glucose in a randomized trial.
- Influence of dietary fat and carbohydrates proportions on plasma lipids, glucose control and low-grade inflammation in patients with type 2 diabetes-The TOSCA.IT Study
PubMed ID: 26303195
Observational cohort in T2D linked higher fiber intake to lower long‑term glucose (HbA1c), supporting glycemic benefits.
- Nut-enriched bread is an effective and acceptable vehicle to improve regular nut consumption
PubMed ID: 26358166
Hazelnut‑enriched bread reduced postprandial glucose AUC versus control—demonstrates food‑based fiber effect on glycaemia.
- Effects of total fibre or resistant starch-rich diets within lifestyle intervention in obese prediabetic adults
PubMed ID: 25588971
High‑fiber dietary advice improved 2‑h OGTT glycaemia in prediabetic/overweight adults over 12 months.
- Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial
PubMed ID: 26811130
Pea fiber lowered glucose AUC during OGTT in the 12‑week trial.
- The effects of the combination of egg and fiber on appetite, glycemic response and food intake in normal weight adults - a randomized, controlled, crossover trial
PubMed ID: 27306734
Protein + fiber breakfasts reduced postprandial glycemic response acutely vs a low‑protein cereal breakfast.
- Short- and Long-Term Effects of Wholegrain Oat Intake on Weight Management and Glucolipid Metabolism in Overweight Type-2 Diabetics: A Randomized Control Trial
PubMed ID: 27618090
Whole‑grain oats reduced postprandial glucose (−1.17 mmol/L) and HbA1c (−0.64%) at 1 year in overweight people with T2D.
- Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial)
PubMed ID: 27733151
Psyllium markedly lowered fasting glucose (−43.6 mg/dL) and HbA1c (−0.9%) over 8 weeks.
- Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial
PubMed ID: 27919453
Buckwheat substitution modestly lowered fasting insulin in T2D over 4 weeks—evidence for improved glycemic control (short term, whole‑food intervention).
- Acute effects of different dietary polysaccharides added in milk on food intake, postprandial appetite and glycemic responses in healthy young females
PubMed ID: 27352777
Guar gum and alginate acutely suppressed postprandial glucose—strong acute evidence that viscous fibers blunt glycemic excursions.
- Greater diet quality is associated with more optimal glycemic control in a longitudinal study of youth with type 1 diabetes
PubMed ID: 27194309
Observational associations in youth with T1D: higher fiber linked to better CGM metrics and 1,5‑AG—supports improved glycemic stability.
- Glycemic Index of a Novel High-Fiber White Rice Variety Developed in India--A Randomized Control Trial Study
PubMed ID: 26741823
High‑fiber white rice produced a ~23% lower glycemic index versus conventional white rice in humans—direct evidence for steadier postprandial glycemia.
- Effects of oat bran and nutrition counseling on the lipid and glucose profile and anthropometric parameters of hypercholesterolemia patients
PubMed ID: 27019267
Oat bran (40 g/day) improved insulin‑resistance measures and decreased blood glucose only in the oat bran group—evidence for steadier blood sugar with concentrated oat fiber.
- Efficacy of different fibres and flour mixes in South-Asian flatbreads for reducing post-prandial glucose responses in healthy adults
PubMed ID: 27324141
Adding viscous fibres (guar gum, konjac, chickpea) to flatbreads reduced 2‑h postprandial glucose iAUC by ~30–40% — strong, direct evidence.
- Replacement of glycaemic carbohydrates by inulin-type fructans from chicory (oligofructose, inulin) reduces the postprandial blood glucose and insulin response to foods: report of two double-blind, randomized, controlled trials
PubMed ID: 28255654
Replacing sugars with inulin/oligofructose in foods significantly reduced postprandial glucose and insulin iAUC in crossover trials.
- Co-administration of a konjac-based fibre blend and American ginseng (Panax quinquefolius L.) on glycaemic control and serum lipids in type 2 diabetes: a randomized controlled, cross-over clinical trial
PubMed ID: 28687934
Konjac glucomannan blend significantly reduced HbA1c over 12 weeks in type 2 diabetes patients.
- Effect on Insulin, Glucose and Lipids in Overweight/Obese Australian Adults of 12 Months Consumption of Two Different Fibre Supplements in a Randomised Trial
PubMed ID: 28146065
PGX and psyllium lowered fasting insulin and HOMA‑IR, indicating improved glycemic control.
- Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial
PubMed ID: 29162875
Fibre‑rich diet improved insulin sensitivity and reduced HbA1c in prediabetes/fatty‑liver participants.
- Impact of a Plant-Based Diet and Support on Mitigating Type 2 Diabetes Mellitus in Latinos Living in Medically Underserved Areas
PubMed ID: 28503930
High‑fiber, low‑fat plant diet reduced long‑term blood sugar (A1C) in people with diabetes.
- Short-Term Supplementation of a Moderate Carbohydrate Diet with Psyllium Reduces Fasting Plasma Insulin and Tumor Necrosis Factor-α in Patients with Type 2 Diabetes Mellitus
PubMed ID: 28956658
Psyllium supplementation lowered fasting insulin and improved insulin sensitivity in T2D, indicating better glycemic control.
- [Effect of quinua (Chenopodium quinoa)consumption as a coadjuvant in nutritional intervention in prediabetic subjects]
PubMed ID: 29130716
Processed quinoa reduced HbA1c in prediabetics over 28 days, indicating improved glycemic control.
- Fibre supplementation for the prevention of type 2 diabetes and improvement of glucose metabolism: the randomised controlled Optimal Fibre Trial (OptiFiT)
PubMed ID: 29492637
Insoluble oat fiber produced a small HbA1c improvement in a 2-year trial
- Type-4 Resistant Starch in Substitution for Available Carbohydrate Reduces Postprandial Glycemic Response and Hunger in Acute, Randomized, Double-Blind, Controlled Study
PubMed ID: 29373530
RS4 scone sharply lowered glucose and insulin responses vs control
- Effects of supplemented isoenergetic diets varying in cereal fiber and protein content on the bile acid metabolic signature and relation to insulin resistance
PubMed ID: 29549243
High cereal fiber improved insulin sensitivity in overweight participants
- Impact of Diets Rich in Whole Grains and Fruits and Vegetables on Cardiovascular Risk Factors in Overweight and Obese Women: A Randomized Clinical Feeding Trial
PubMed ID: 29702040
Whole-grain diet improved fasting glucose among overweight/obese women, indicating better glycemic control.
- Effects of Quinoa (Chenopodium quinoa Willd.) Consumption on Markers of CVD Risk
PubMed ID: 29914146
Daily quinoa bread led to small improvements in fasting and postprandial glucose AUC versus refined wheat.
- A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects
PubMed ID: 30541093
Whole-grain preserved metabolic health (liver fat) and microbiota—indirectly favorable to glycemic stability.
- A Synergistic Formulation of Plant Extracts Decreases Postprandial Glucose and Insulin Peaks: Results from Two Randomized, Controlled, Cross-Over Studies Using Real-World Meals
PubMed ID: 30044398
Multi-extract supplement (including inulin/glucomannan in one formulation) lowered postprandial glucose and insulin peaks in a randomized crossover; fiber contribution plausible but mixed-ingredient.
- Postprandial glucose-lowering effect of premeal consumption of protein-enriched, dietary fiber-fortified bar in individuals with type 2 diabetes mellitus or normal glucose tolerance
PubMed ID: 29502350
Premeal bar with 12.7 g fiber produced large, statistically significant reductions in postprandial glucose and insulin in T2DM and healthy subjects — very strong direct evidence.
- A Plant-Based High-Carbohydrate, Low-Fat Diet in Overweight Individuals in a 16-Week Randomized Clinical Trial: The Role of Carbohydrates
PubMed ID: 30223451
High-fiber plant-based diet reduced HOMA-IR and improved insulin resistance — strong evidence of blood sugar stabilization over 16 weeks.
- Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals
PubMed ID: 29795366
Cohort linking a fiber-associated microbial metabolite (IPA) to lower T2D risk supports fiber's role in glucose regulation via microbiome pathways.
- Success in Achieving the Targets of the 20-Year Infancy-Onset Dietary Intervention: Association With Insulin Sensitivity and Serum Lipids
PubMed ID: 30072407
Children who met higher whole-grain/fruit/veg/fiber targets had better insulin sensitivity and glucose/insulin profiles through youth.
- A proof-of-concept study to evaluate the efficacy and safety of BTI320 on post-prandial hyperglycaemia in Chinese subjects with pre-diabetes
PubMed ID: 30170579
Galactomannan (BTI320) reduced CGM‑measured postprandial glucose excursions and mean post‑meal glucose levels in prediabetes.
- A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome markers
PubMed ID: 30382274
Grape pomace lowered fasting insulin in metabolic‑risk subjects—supporting improved glycaemic control.
- Development and Efficacy of an Electronic, Culturally Adapted Lifestyle Counseling Tool for Improving Diabetes-Related Dietary Knowledge: Randomized Controlled Trial Among Ethnic Minority Adults With Type 2 Diabetes Mellitus
PubMed ID: 31621640
Dietary counseling that increased fiber was associated with improved HbA1c in people with T2DM (behavioral intervention).
- Snack selection influences glucose metabolism, antioxidant capacity and cholesterol in healthy overweight adults: A randomized parallel arm trial
PubMed ID: 30952505
Dried plum snack lowered postprandial insulin and produced favorable postprandial metabolic responses.
- Okara Improved Blood Glucose Level in Vietnamese with Type 2 Diabetes Mellitus
PubMed ID: 30814413
Okara fiber supplementation for 2 weeks lowered fasting glucose and fructosamine in people with type 2 diabetes.
- Impact of oat processing on glycaemic and insulinaemic responses in healthy humans: a randomised clinical trial
PubMed ID: 31068229
Clear evidence that less-processed (steel-cut) oats produced lower glucose peak-rise and lower glucose iAUC versus refined control.
- Obesity Does Not Modulate the Glycometabolic Benefit of Insoluble Cereal Fibre in Subjects with Prediabetes-A Stratified Post Hoc Analysis of the Optimal Fibre Trial (OptiFiT)
PubMed ID: 31717901
Insoluble cereal fibre supplementation gave modest improvements in 2-hour OGTT glucose in obese participants—supportive of improved glycemic control.
- Effect of dietary intervention with a legume-based food product on malondialdehyde levels, HOMA index, and lipid profile
PubMed ID: 31759909
Legume product lowered fasting glucose and HOMA-IR over 3 months—evidence of improved glycemic stability.
- Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults: A Randomized Clinical Trial
PubMed ID: 33252690
High-fiber vegan diet markedly improved insulin sensitivity (HOMA/PREDIM) and reduced liver/muscle fat (direct glycemic/metabolic benefits).
- Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort
PubMed ID: 32369545
Large cohort found higher fiber associated with lower type 2 diabetes risk—supports fiber's role in glycemic control over time.
- Carbohydrate quality changes and concurrent changes in cardiovascular risk factors: a longitudinal analysis in the PREDIMED-Plus randomized trial
PubMed ID: 31868210
Population trial: improved carbohydrate quality (including more fiber) linked to better HbA1c and other glycemic markers over 12 months.
- Impact of the Dietary Approaches to Stop Hypertension (DASH) diet on glycaemic control and consumption of processed and ultraprocessed foods in pregnant women with pre-gestational diabetes mellitus: a randomised clinical trial
PubMed ID: 33256869
DASH (higher‑fiber) diet markedly increased proportion achieving glycaemic control in pregnant women with pre‑gestational diabetes (clinical glycaemic outcome).
- Human clinical trial to assess the effect of consumption of multigrain Indian bread on glycemic regulation in type 2 diabetic participants
PubMed ID: 33006193
Multigrain millet flatbread reduced fasting insulin and HbA1c in people with T2DM (clinical, sustained glycemic benefit).
- Dietary Fibres and the Management of Obesity and Metabolic Syndrome: The RESOLVE Study
PubMed ID: 32977595
During the RESOLVE intervention greater fiber intake was associated with reductions in fasting glucose and HbA1c, showing improved glycaemic control.
- Effect of a functional fibre supplement on glycemic control when added to a year-long medically supervised weight management program in adults with type 2 diabetes
PubMed ID: 32642971
PGX group had a small within‑group HbA1c decrease over 52 weeks (supports modest glycemic improvement).
- Ingestion of Helianthus tuberosus at Breakfast Rather Than at Dinner Is More Effective for Suppressing Glucose Levels and Improving the Intestinal Microbiota in Older Adults
PubMed ID: 33022987
Inulin (Helianthus tuberosus, 5 g/day) lowered 24‑h and postprandial glucose in older adults (direct glycemic benefit, randomized crossover timing effect).
- Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial
PubMed ID: 34226737
Low‑fermentable fiber combined with oral FMT modestly improved insulin sensitivity at 6 weeks in severe obesity (direct insulin‑sensitivity outcome).
- Interventional effect of dietary fiber on blood glucose and pregnancy outcomes in patients with gestational diabetes mellitus
PubMed ID: 34402253
RCT in gestational diabetes: ~9.5 g/day extra fiber improved 2‑hour postprandial glucose and reduced postpartum impaired glucose tolerance — strong glycemic benefit.
- The effect of oat bran consumption on gestational diabetes: a randomized controlled clinical trial
PubMed ID: 33849494
Oat bran in gestational diabetes robustly lowered fasting and 2‑hr postprandial glucose over 4 weeks → strong glycemic stabilization evidence.
- Efficacy of green jackfruit flour as a medical nutrition therapy replacing rice or wheat in patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study
PubMed ID: 34127645
Replacing staples with fiber‑rich jackfruit flour produced clinically meaningful reductions in HbA1c, fasting and postprandial glucose over 12 weeks — strong direct evidence.
- Comparison of the Effects of a Bean-Based and a White Rice-Based Breakfast Diet on Postprandial Glucose and Insulin Levels in Chinese Patients with Type 2 Diabetes
PubMed ID: 33785707
Bean‑based (higher‑fiber, low‑GI) breakfast produced much smaller postprandial glucose excursions in people with T2D — clear acute glycemic benefit.
- Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention-Association with Metabolic Profile from Childhood to Adulthood
PubMed ID: 33562015
Meeting dietary goals including higher fiber was associated with lower glucose-related metabolites in children/adolescents — suggests improved glycemic profile.
- Effect of a ketogenic diet versus Mediterranean diet on glycated hemoglobin in individuals with prediabetes and type 2 diabetes mellitus: The interventional Keto-Med randomized crossover trial
PubMed ID: 35641199
In prediabetes/T2DM trial both diets improved blood sugar; the Mediterranean-style (higher-fiber) diet supported glycemic improvements, implicating fiber-containing diet benefits.
- Chronic consumption of probiotics, oats, and apples has differential effects on postprandial bile acid profile and cardiometabolic disease risk markers compared with an isocaloric control (cornflakes): a randomized trial
PubMed ID: 36811563
Eating oats or apples lowered post‑meal insulin and C‑peptide responses acutely — fiber‑rich foods reducing glycemic/insulin excursions.
- An Isoenergetic Multifactorial Diet Reduces Pancreatic Fat and Increases Postprandial Insulin Response in Patients With Type 2 Diabetes: A Randomized Controlled Trial
PubMed ID: 35862001
Multifactorial diet—including more fiber—raised early postprandial insulin response and reduced pancreatic fat; fiber contributed to glycaemic changes.
- Changes in Food and Nutrient Intake and Diet Quality on a Low-Fat Vegan Diet Are Associated with Changes in Body Weight, Body Composition, and Insulin Sensitivity in Overweight Adults: A Randomized Clinical Trial
PubMed ID: 35452873
Vegan diet increased fiber and showed modest HOMA‑IR improvements (multi‑component intervention).
- Increased vegetable intake improves glycaemic control in adults with type 2 diabetes mellitus: a clustered randomised clinical trial among Indonesian white-collar workers
PubMed ID: 35836691
Raw‑vegetable (fiber‑rich) empowerment intervention produced large HbA1c and fasting/postprandial glucose improvements in T2D patients.
- Probiotics Plus Dietary Fiber Supplements Attenuate Olanzapine-Induced Weight Gain in Drug-Naïve First-Episode Schizophrenia Patients: Two Randomized Clinical Trials
PubMed ID: 35569003
Probiotics + dietary fiber reduced fasting insulin and HOMA‑IR in olanzapine‑treated patients—supports improved glycemic regulation.
- Increasing the diversity of dietary fibers in a daily-consumed bread modifies gut microbiota and metabolic profile in subjects at cardiometabolic risk
PubMed ID: 35311446
Multi‑fiber bread lowered fasting insulin and HOMA‑IR—supportive for better glycemic control/steadier blood sugar.
- Effectiveness of Textured Soybean Protein on Blood Biochemistry in Vietnamese Type 2 Diabetes Mellitus Patients
PubMed ID: 35228493
Textured soybean protein (higher fiber) reduced fructosamine modestly over 4 weeks—evidence of improved glycemia albeit multifactorial.
- Tapioca Resistant Maltodextrin as a Carbohydrate Source of Oral Nutrition Supplement (ONS) on Metabolic Indicators: A Clinical Trial
PubMed ID: 35267892
Tapioca resistant maltodextrin significantly reduced postprandial insulin and lowered HbA1c over 12 weeks in small cohorts.
- The role of dietary fiber on preventing gestational diabetes mellitus in an at-risk group of high triglyceride-glucose index women: a randomized controlled trial
PubMed ID: 37737931
Large RCT in pregnancy: 24 g/day fiber powder halved gestational diabetes incidence and reduced postprandial glucose—strong direct evidence.
- Effects of a novel rice-based diabetes-specific formula on postprandial glucose and gastrointestinal hormones: a double-blinded multi-arm randomized crossover trial
PubMed ID: 37293492
A fiber-containing diabetes-specific formula produced significantly lower postprandial glucose and insulin AUCs—strong direct evidence for steadier post-meal glycemia.
- HIGH-FIBER DIET PROMOTES METABOLIC, HORMONAL, AND SATIETY EFFECTS IN OBESE WOMEN ON A SHORT-TERM CALORIC RESTRICTION
PubMed ID: 37556741
High‑fiber calorie‑restricted diet decreased fasting glucose, insulin and HOMA‑IR in obese women.
- Consumption of Tree Nuts as Snacks Reduces Metabolic Syndrome Risk in Young Adults: A Randomized Trial
PubMed ID: 38140310
Nut snack replacement lowered insulin and improved TG/HDL ratio trends—consistent with cardiometabolic/glycemic benefits (multi‑nutrient).
- Effect of nutritional promotion intervention on dietary adherence among type II diabetes patients in North Shoa Zone Amhara Region: quasi-experimental study
PubMed ID: 37254151
Six‑month nutrition promotion in T2D increased recommended (high‑fiber) foods and improved fasting blood glucose.
- Changes in quantity plant-based protein intake on type 2 diabetes remission in coronary heart disease patients: from the CORDIOPREV study
PubMed ID: 36869909
Observational within dietary counselling showed shifting toward plant‑based foods (higher fiber) was associated with better glycemic control and higher diabetes remission rates.
- Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota
PubMed ID: 38409604
Resistant starch improved insulin sensitivity (increased GIR) and produced metabolic benefits—direct glycemic effect.
- Diabetes Therapeutics of Prebiotic Soluble Dietary Fibre and Antioxidant Anthocyanin Supplement in Patients with Type 2 Diabetes: Randomised Placebo-Controlled Clinical Trial
PubMed ID: 40218856
60‑day inulin + rice bran (fiber) + anthocyanins produced clinically meaningful reductions in FPG and HbA1c in T2DM (DBPC RCT).
- Administration of a diabetes-specific formula can improve postprandial glycemic control and delay insulin use in gestational diabetes mellitus: A randomized controlled trial from two centers
PubMed ID: 39536397
Diabetes‑specific fiber‑containing formula in GDM improved 2‑hour postprandial glucose, increased time‑in‑range, and delayed insulin initiation.
- Long-term clinical efficacy of dietary fiber supplementation in middle-aged and elderly prediabetic patients
PubMed ID: 39406174
Mixed fiber supplementation reduced fasting and 2‑hour glucose and lowered diabetes incidence in prediabetic older adults.
- Effects of dietary fiber on maternal health in pregnant women with metabolic syndrome risk: a randomized controlled trial
PubMed ID: 38809131
Pregnancy trial: higher dietary fiber and soluble fiber supplementation associated with lower GDM risk and favorable glucose/triglyceride changes.
- Effects of a diverse prebiotic fibre supplement on HbA1c, insulin sensitivity and inflammatory biomarkers in pre-diabetes: a pilot placebo-controlled randomised clinical trial
PubMed ID: 38654680
Prebiotic fiber supplement improved insulin sensitivity (whole‑cohort) and had a small HbA1c benefit in a subgroup — supports glycemic stability.
- Twelve Weeks of Daily Lentil Consumption Improves Fasting Cholesterol and Postprandial Glucose and Inflammatory Responses-A Randomized Clinical Trial
PubMed ID: 38337705
Daily lentil meals lowered postprandial glucose AUC and fasting lipids — direct postprandial glucose benefit.
- Jaboticaba peel improves postprandial glucose and inflammation: A randomized controlled trial in adults with metabolic syndrome
PubMed ID: 38493538
Jaboticaba‑peel powder (fiber‑rich) modestly lowered post‑meal glucose exposure over 5 weeks in metabolic syndrome subjects.
- Effect of a diabetes-specific formula in non-diabetic inpatients with stroke: a randomized controlled trial
PubMed ID: 38816400
In stroke patients on enteral feeds, a diabetes‑specific (lower‑GI, fiber‑containing) formula markedly reduced inpatient hyperglycemia vs standard formula.
- Effects of a Short-Term Vegan Challenge in Older Adults on Metabolic and Inflammatory Parameters-A Randomized Controlled Crossover Study
PubMed ID: 38185769
48‑hour vegan (higher‑fiber) challenge in older adults reduced insulin and HOMA (insulin resistance) acutely.
- Personalized Microbial Fingerprint Associated with Differential Glycemic Effects of a Whole Grain Rye Intervention on Chinese Adults
PubMed ID: 39091068
Whole‑grain rye lowered blood glucose in a subgroup of participants (responders); baseline microbiome predicted benefit—moderate evidence for rye (fiber) improving glycemia in some people.
- A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial
PubMed ID: 39843443
Legume‑rich high‑fibre feeding trial showed improved HbA1c and early microbiome/metabolite shifts linked to glycemia.
- Gut microbiome predicts personalized responses to dietary fiber in prediabetes: a randomized, open-label trial
PubMed ID: 41390484
Large RCT of fiber supplements in prediabetes demonstrated significant, cluster‑specific reductions in FPG and HbA1c.
- Impact of a 12-week personalized dietary intervention on vascular function and cardiovascular risk factors
PubMed ID: 40013435
Phenotype‑guided diets including fiber increased insulin sensitivity measures.
- Impact of a high dietary fiber cereal meal intervention on the progression of liver fibrosis in T2DM with MASLD
PubMed ID: 40958906
Daily 24 g fiber cereal for 12 weeks markedly improved HbA1c (−1.6% in 24 g group) in T2DM, direct evidence for glycemic stability.
- ApoC-III and ectopic fat accumulation in individuals with type 2 diabetes: an exploratory analysis from the MEDEA randomised controlled study
PubMed ID: 40471240
A diet that included more fiber reduced postprandial ApoC‑III and was associated with lower liver/pancreatic fat and better beta‑cell function—metabolic changes consistent with improved glycemic stability.
- Supplementing the standard diet with brown rice bran powder might effectively improve the metabolic syndrome characteristics and antioxidant status: an open label randomized controlled trial
PubMed ID: 39775811
Brown rice bran reduced fasting blood glucose in metabolic syndrome participants.
- NUTRIOSE® soluble fibre supplementation as an effective dietary strategy to improve glycaemic response
PubMed ID: 40167751
NUTRIOSE soluble fiber RCT improved 24‑hour glycaemic control and postprandial responses, strongest direct evidence here.
- Development and empirical evaluation of a dietary intervention programme for individuals with prediabetes based on the health action process approach: A randomised controlled trial
PubMed ID: 41421300
Prediabetes dietary program increased fibre‑rich foods and improved fasting and 2‑hour plasma glucose.
- A dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnormalities by modifying faecal microbiota in people with type 2 diabetes
PubMed ID: 30266575
High‑fiber, polyphenol diet significantly reduced HbA1c in 3 months—strong evidence of improved glycemic control.
- Effects of Dietary Intervention on Gut Microbiota and Metabolic-Nutritional Profile of Outpatients with Non-Alcoholic Steatohepatitis: a Randomized Clinical Trial
PubMed ID: 31517324
3‑month dietary program including ~30 g fiber/day improved HOMA‑IR and glycemic markers; fiber likely contributed.
- Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
PubMed ID: 35300378
Konjac lowered HbA1c modestly in obese adults—supports steadier glycemia with fermentable fiber.
- Effects of a healthy Nordic diet on cardiovascular risk factors in hypercholesterolaemic subjects: a randomized controlled trial (NORDIET)
PubMed ID: 20964740
Nordic diet lowered fasting insulin (improved glycaemic marker) in a randomized trial that included increased plant/fiber foods.
- Dietary changes and associations with metabolic improvements in adults with type 2 diabetes during a patient-centred dietary intervention: an exploratory analysis
PubMed ID: 24928586
Diabetes dietary program produced a small HbA1c improvement while maintaining fibre intake—clinical evidence of improved glycaemic control in a fibre‑preserved diet context.
- High hydrostatic pressure processing reduces the glycemic index of fresh mango puree in healthy subjects
PubMed ID: 25797308
High‑pressure processed mango puree (higher viscosity/structure akin to fibre effects) produced markedly lower GI and lower postprandial AUC—strong direct evidence for steadier glycemia.
- Metabolomics-Based Biomarker for Dietary Fat and Associations with Chronic Disease Risk in Postmenopausal Women
PubMed ID: 37245660
Prospective analysis showed many diet–disease associations (including CHD/diabetes links) were attenuated by fiber, indicating fiber influences glycemic/cardiometabolic risk.
- Association of dietary fibre with type 2 diabetes risk is modified by transcription factor 7 like 2 genotype in men with impaired fasting glucose: The T2D-GENE study
PubMed ID: 40961511
Large trial found greater dietary fiber associated with much lower development of type 2 diabetes and smaller rises in blood glucose (fasting and AUC), providing strong direct evidence for glycemic stabilization.
- Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial
PubMed ID: 18460483
Ground flaxseed improved insulin sensitivity (HOMA‑IR reduced 23.7%) in hypercholesterolemic adults.
- Gastrointestinal microbiome modulator improves glucose tolerance in overweight and obese subjects: A randomized controlled pilot trial
PubMed ID: 26424589
4‑week inulin + β‑glucan blend reduced postprandial glucose excursions and increased satiety signals.
- An Anthocyanin-Rich Mixed-Berry Intervention May Improve Insulin Sensitivity in a Randomized Trial of Overweight and Obese Adults
PubMed ID: 31775396
Mixed‑berry interventions lowered postprandial insulin AUC under controlled feeding—improves glycemic handling.
Cholesterol (219)
- Beta-glucan incorporated into a fruit drink effectively lowers serum LDL-cholesterol concentrations
PubMed ID: 16522906
5 g oat β‑glucan drink lowered LDL and total cholesterol with absorption marker changes.
- Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial
PubMed ID: 17386092
Concentrated oat β‑glucan lowered LDL and total cholesterol over 6 weeks—direct cholesterol lowering evidence.
- Simultaneous intake of beta-glucan and plant stanol esters affects lipid metabolism in slightly hypercholesterolemic subjects
PubMed ID: 17311944
Beta‑glucan lowered LDL (−5%) and, with plant stanols, produced additive LDL reductions with biomarker support (reduced absorption, ↑bile acid synthesis).
- The consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes
PubMed ID: 19230737
3 g/day β‑glucan in T2D produced a notable LDL‑C decrease (0.66 mmol/L, 15.8%).
- Physicochemical properties of oat β-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial
PubMed ID: 20660224
Large trial: 3 g/day high‑MW β‑glucan produced modest but significant LDL reductions (~4–6%); viscosity predicted efficacy.
- Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians
PubMed ID: 22118569
Pooled data across ethnicities showing modest LDL reductions (4.8–10.3%) with bioactive oat β‑glucan.
- A randomized Placebo-Controlled Clinical Trial to Evaluate the Medium-Term Effects of Oat Fibers on Human Health: The Beta-Glucan Effects on Lipid Profile, Glycemia and inTestinal Health (BELT) Study
PubMed ID: 32138344
3 g/day high‑MW oat β‑glucan reduced LDL‑C by ~15% and total cholesterol by ~9% after 8 weeks.
- The role of soluble fiber intake in patients under highly effective lipid-lowering therapy
PubMed ID: 21810257
Soluble fiber reduced plasma plant sterol levels and produced small metabolic improvements including a modest glucose reduction.
- Metabolite Biomarkers Linking a High-Fiber Rye Intervention with Cardiometabolic Risk Factors: The RyeWeight Study
PubMed ID: 40838659
High‑fiber rye produced favorable weight/fat and CRP changes that support lipid/heart health; metabolic benefits seen in large RCT.
- Preventive effects of diets supplemented with sweetie fruits in hypercholesterolemic patients suffering from coronary artery disease
PubMed ID: 15193907
Sweetie fruit supplementation lowered TC, LDL and TG in hypercholesterolaemic post-CABG patients.
- The formation of short-chain fatty acids is positively associated with the blood lipid-lowering effect of lupin kernel fiber in moderately hypercholesterolemic adults
PubMed ID: 24572041
Lupin kernel fiber produced clinically meaningful reductions in total and LDL cholesterol (randomized crossover).
- Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake
PubMed ID: 32075887
Isocaloric Mediterranean pattern with doubled fibre intake lowered total/LDL cholesterol in adults—direct evidence.
- Effects of Wholegrain Compared to Refined Grain Intake on Cardiometabolic Risk Markers, Gut Microbiota, and Gastrointestinal Symptoms in Children: A Randomized Crossover Trial
PubMed ID: 37898434
Wholegrain oats/rye replacement slightly lowered LDL cholesterol and triglycerides in children (direct lipid lowering effect).
- An Indian experiment with nutritional modulation in acute myocardial infarction
PubMed ID: 1550016
Diet higher in complex carbs and soluble fibre after MI led to substantial reductions in total and LDL cholesterol (direct clinical evidence, though multifactorial).
- Reduced serum cholesterol with dietary change using fat-modified and oat bran supplemented diets
PubMed ID: 2154513
Oat bran (soluble fiber) or low‑fat diet arms showed ~10–17% reductions in total cholesterol—strong evidence for fiber lowering cholesterol.
- Characteristics of the diet patterns tested in the optimal macronutrient intake trial to prevent heart disease (OmniHeart): options for a heart-healthy diet
PubMed ID: 18237574
DASH‑like controlled feeding lowered LDL; while fiber was constant, diets emphasizing fiber are associated with improved cholesterol.
- Effects of soy as tofu vs meat on lipoprotein concentrations
PubMed ID: 10694766
Replacing lean meat with tofu (dietary change including plant fiber) modestly lowered total cholesterol and triglycerides in healthy men.
- A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins, and plasma total homocysteine in hypercholesterolemic subjects
PubMed ID: 12081819
Large randomized trial: soy protein product (including cotyledon fiber) reduced LDL cholesterol in hypercholesterolemic adults.
- The diet and moderate exercise trial (DAMET): results after 24 weeks
PubMed ID: 1290315
Randomized trial of fruit/veg (fiber‑rich) diet + exercise produced clinically meaningful LDL and total cholesterol reductions (confounded by exercise).
- Long-term effects of water-soluble dietary fiber in the management of hypercholesterolemia in healthy men and women
PubMed ID: 9024732
6‑month randomized trial: sustained ~6% total and ~10% LDL decreases with 15 g/day WSDF mixture.
- A dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnormalities by modifying faecal microbiota in people with type 2 diabetes
PubMed ID: 30266575
Intervention lowered LDL cholesterol; fiber likely contributed as part of the high‑fiber, polyphenol diet.
- A factorial study of salt restriction and a low-fat/high-fibre diet in hypertensive subjects
PubMed ID: 1315827
Low‑fat/high‑fiber diet reduced total and LDL cholesterol in a randomized factorial trial — direct evidence that a diet including fiber can lower cholesterol (though diet had multiple components).
- Can guava fruit intake decrease blood pressure and blood lipids?
PubMed ID: 8383769
High soluble-fiber guava intervention produced modest reductions in total cholesterol (≈−7.9%) and triglycerides — direct support that soluble fiber can improve lipids.
- Zinc intake and plasma zinc level are maintained in men consuming cholesterol-lowering diets
PubMed ID: 7594123
Study context was higher-fiber, cholesterol‑lowering diets (supports fiber's role in cholesterol‑lowering dietary patterns even though primary reported outcome was zinc preservation).
- Effects of a healthy Nordic diet on cardiovascular risk factors in hypercholesterolaemic subjects: a randomized controlled trial (NORDIET)
PubMed ID: 20964740
Randomized trial showed a Nordic diet high in plant/fiber foods reduced LDL cholesterol by ~21% (strong clinical result, though multi‑component diet).
- Low dose chromium-polynicotinate or policosanol is effective in hypercholesterolemic children only in combination with glucomannan
PubMed ID: 23453352
Randomized pediatric trial: glucomannan (soluble fiber) plus chromium lowered total and LDL cholesterol by ~15% versus control.
- Brown and golden flaxseed reduce intestinal permeability and endotoxemia, and improve the lipid profile in perimenopausal overweight women
PubMed ID: 35311432
Flaxseed lowered LDL (in perimenopausal overweight women) in a randomized trial — direct cholesterol‑lowering evidence from a fiber‑rich food.
- Effect of unsaturated fat and protein intake on liver fat in people at risk of unhealthy aging: 1-year results of a randomized controlled trial
PubMed ID: 36804020
A 12-month diet including ≥30 g/day fiber (along with other macronutrient changes) reduced LDL and total cholesterol in adherent participants — fiber likely contributed to lipid improvements.
- Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial
PubMed ID: 18460483
Ground flaxseed transiently lowered LDL (−13% at 5 weeks) and reduced Lp(a) in hypercholesterolemic adults.
- Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patients
PubMed ID: 22470031
One-month inulin/FOS/ALA-enriched cookies significantly improved total and LDL cholesterol in obese men.
- Walnuts and Vegetable Oils Containing Oleic Acid Differentially Affect the Gut Microbiota and Associations with Cardiovascular Risk Factors: Follow-up of a Randomized, Controlled, Feeding Trial in Adults at Risk for Cardiovascular Disease
PubMed ID: 31848609
Walnut diet altered microbiota and associated with reductions in total and LDL cholesterol in the parent trial; fiber likely contributed.
- Diabetes Therapeutics of Prebiotic Soluble Dietary Fibre and Antioxidant Anthocyanin Supplement in Patients with Type 2 Diabetes: Randomised Placebo-Controlled Clinical Trial
PubMed ID: 40218856
Inulin + rice bran (fiber) + anthocyanins lowered LDL‑C ~13% in T2DM (DBPC RCT).
- Hypocholesterolaemic effects of lupin protein and pea protein/fibre combinations in moderately hypercholesterolaemic individuals
PubMed ID: 22032303
Large randomized trial: plant protein + soluble fiber (oat or pectin) bars significantly lowered total cholesterol (and LDL parallel).
- Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity
PubMed ID: 18729243
Konjac (glucomannan) plus Garcinia reduced total and LDL cholesterol in a randomized trial—cholesterol reduction is plausible for viscous fibres, though co‑administration lowers certainty.
- Cholesterol-lowering effect of barley bran flour and oil
PubMed ID: 8270757
Barley bran added to a cholesterol‑lowering diet significantly reduced total and LDL cholesterol over 30 days.
- The effects of concentrated barley beta-glucan on blood lipids in a population of hypercholesterolaemic men and women
PubMed ID: 17445284
Randomized, placebo-controlled trial of concentrated barley β-glucan with dose-dependent, clinically meaningful LDL-C reductions.
- Physiological effects of concentrated barley beta-glucan in mildly hypercholesterolemic adults
PubMed ID: 18838533
6 g/day barley β-glucan produced small changes in cholesterol/HDL ratio; effects modest.
- Combining functional features of whole-grain barley and legumes for dietary reduction of cardiometabolic risk: a randomised cross-over intervention in mature women
PubMed ID: 24063257
Barley + legume dietary intervention reduced total and LDL cholesterol and apoB vs control.
- High-Molecular-Weight β-Glucan Decreases Serum Cholesterol Differentially Based on the CYP7A1 rs3808607 Polymorphism in Mildly Hypercholesterolemic Adults
PubMed ID: 26936139
3 g/day HMW barley β‑glucan produced a small but significant total cholesterol reduction in mildly hypercholesterolemic adults.
- Barley β-glucan reduces blood cholesterol levels via interrupting bile acid metabolism
PubMed ID: 29115200
3 g/day high‑MW barley β‑glucan lowered total cholesterol and raised bile acid synthesis (mechanistic RCT).
- Barley β-glucan increases fecal bile acid excretion and short chain fatty acid levels in mildly hypercholesterolemic individuals
PubMed ID: 29872803
HMW β‑glucan increased fecal bile acid loss and colonic fermentation (supports cholesterol lowering mechanistically).
- Alterations in gut microbiota composition and metabolic parameters after dietary intervention with barley beta glucans in patients with high risk for metabolic syndrome development
PubMed ID: 30396006
4‑week 6 g β‑glucan bread modestly lowered plasma cholesterol (significant) and increased fecal propionate.
- Nutritional and health benefits of a partial substitution of red and processed meat with non-soy legumes: a 6-week randomized controlled trial in healthy working-age men
PubMed ID: 40828321
Legume replacement increased fiber and produced statistically significant LDL/total cholesterol reductions in a randomized trial.
- Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial
PubMed ID: 11829698
Randomized crossover diet higher in fiber lowered LDL ~10.8% in hypercholesterolemic men — direct lipid benefit.
- Metabolomic profiling of a cholesterol lowering plant-based diet from two randomized controlled feeding trials
PubMed ID: 40263496
Metabolomic shifts in two RCTs were consistent with a portfolio (viscous-fiber–containing) cholesterol-lowering diet; however changes reflect the whole diet, not fiber in isolation.
- Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds
PubMed ID: 25326876
Portfolio diet including viscous fibre produced ≈13% LDL‑C reduction in a large RCT.
- The hypocholesterolemic effects of beta-glucan in oatmeal and oat bran. A dose-controlled study
PubMed ID: 2005733
Oatmeal/oat‑bran β‑glucan produced clear, dose‑dependent LDL reductions up to ~16%.
- A controlled study on the effect of beta-glucan-rich oat bran on serum lipids in hypercholesterolemic subjects: relation to apolipoprotein E phenotype
PubMed ID: 1334101
Oat‑bran lowered total and LDL cholesterol at 4 weeks though not sustained at 8 weeks (transient effect).
- Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial
PubMed ID: 11976156
Four servings/day of FDA‑approved soluble fibers produced modest but significant cholesterol reductions.
- Food products containing free tall oil-based phytosterols and oat beta-glucan lower serum total and LDL cholesterol in hypercholesterolemic adults
PubMed ID: 12612157
Oat β‑glucan + phytosterols modestly lowered LDL—effect partly attributable to the combination.
- Cholesterol-lowering benefits of oat-containing cereal in Hispanic americans
PubMed ID: 15942550
Daily oat cereal with 3 g β‑glucan modestly lowered total and LDL cholesterol vs corn cereal.
- Effect of an Asian-adapted Mediterranean diet and pentadecanoic acid on fatty liver disease: the TANGO randomized controlled trial
PubMed ID: 38035997
Diet + C15:0 intervention lowered LDL (C15:0 effect), and the dietary pattern was fiber‑rich; cholesterol benefit not attributable solely to fiber but present.
- Improved Plasma Lipids, Anti-Inflammatory Activity, and Microbiome Shifts in Overweight Participants: Two Clinical Studies on Oral Supplementation with Algal Sulfated Polysaccharide
PubMed ID: 36005503
SXRG84 produced a significant non-HDL cholesterol decrease in an overweight subgroup.
- Fiber-multivitamin combination therapy: a beneficial influence on low-density lipoprotein and homocysteine
PubMed ID: 12200762
Soluble-fiber + B-vitamin product significantly lowered LDL-C and ApoB vs placebo—direct cholesterol-lowering evidence.
- Is dietary fiber beneficial in chronic ischemic heart disease?
PubMed ID: 11198784
Fenugreek/guar/wheat fiber supplement modestly lowered LDL and increased Apo A‑1 in patients with ischemic heart disease → supportive RCT evidence.
- Synergistic effects of psyllium in the dietary treatment of hypercholesterolemia
PubMed ID: 2218650
Psyllium (~20.4 g/day) added to a cholesterol‑lowering diet produced additional and clinically meaningful LDL/total cholesterol reductions.
- Cholesterol-lowering effects of soluble-fiber cereals as part of a prudent diet for patients with mild to moderate hypercholesterolemia
PubMed ID: 2173390
Psyllium‑enriched cereal produced modest but significant reductions in total and LDL cholesterol (randomized DB trial).
- The effect of foods containing refined Konjac meal on human lipid metabolism
PubMed ID: 2158794
Konjac (glucomannan) foods produced marked reductions in total cholesterol, LDL and triglycerides in hyperlipidemic elderly—strong fiber-specific lipid-lowering evidence.
- Randomized, controlled, crossover trial of oat bran in hypercholesterolemic subjects
PubMed ID: 1660530
Randomized crossover: oat bran lowered total and LDL cholesterol compared with wheat/diet alone—supports cholesterol-lowering by soluble fiber.
- Do beans and oat bran add to the effectiveness of a low-fat diet?
PubMed ID: 1327742
Oat bran/beans improved HDL and LDL/HDL ratio but did not significantly lower total or LDL cholesterol in that trial—moderate support.
- Influence of two guar preparations on glycosylated hemoglobin, total cholesterol and triglycerides in patients with diabetes mellitus
PubMed ID: 1335441
Guar fibre reduced total cholesterol in diabetics across 12 weeks.
- Wheat-bran and oat-bran supplements' effects on blood lipids and lipoproteins
PubMed ID: 1315121
Oat bran reduced total and LDL cholesterol more than wheat bran in a controlled feeding study.
- Lathosterol and other noncholesterol sterols during treatment of hypercholesterolemia with lovastatin alone and with cholestyramine or guar gum
PubMed ID: 1319735
Guar gum with lovastatin produced greater LDL/total cholesterol lowering than lovastatin alone (adjunct effect).
- Cholesterol-lowering effects of psyllium-enriched cereal as an adjunct to a prudent diet in the treatment of mild to moderate hypercholesterolemia
PubMed ID: 1319110
Psyllium‑enriched cereal lowered total and LDL cholesterol in hypercholesterolemic subjects.
- Dietary modulators of lipid metabolism in the Indian diet-heart study (I.D.H.S.)
PubMed ID: 1316885
Randomized diet trial reported significant reductions in total and LDL cholesterol and triglycerides with a higher-fiber diet.
- Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of one year follow up
PubMed ID: 1586782
Post-MI cardioprotective diet rich in soluble fiber produced greater lipid lowering vs control (noting multifactorial diet).
- [Chronic use of glucomannan in the dietary treatment of severe obesity]
PubMed ID: 1313163
Glucomannan supplementation improved lipid status in obese patients (supplement trial).
- Effect of oatbran on mild hyperlipidaemia
PubMed ID: 1331724
Randomized crossover showed 60 g/day oatbran (soluble fiber) lowered LDL and LDL/HDL ratio vs wheatbran.
- Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol
PubMed ID: 8389421
Very high soluble-fiber diets produced modest but significant reductions in total and LDL cholesterol with marked bile-acid loss—strong direct evidence.
- Genetic variation associated with differences in the response of plasma apolipoprotein B levels to dietary fibre
PubMed ID: 8403797
Wheat/oat-bran fiber produced genotype-dependent apoB reductions—evidence fiber can affect atherogenic lipoproteins.
- Effects of diet and lifestyle changes on atherosclerotic risk factors after 24 weeks on the Indian Diet Heart Study
PubMed ID: 8498367
Large multifactorial lifestyle/diet program (including soluble fiber) reduced total and LDL cholesterol by ~13–17% over 24 weeks (fiber likely contributory).
- Diet, lipids and cardiovascular disease in women
PubMed ID: 8409106
Combined trials of AHA/high-fiber diets reported consistent 8–18% reductions in total and LDL cholesterol (dietary-pattern evidence implicates fiber).
- Psyllium reduces blood lipids in men and women with hyperlipidemia
PubMed ID: 8160720
Psyllium (≈6.7 g/day) significantly lowered total and LDL cholesterol in hypercholesterolaemic subjects (randomized crossover).
- The cholesterol-lowering effect of a breakfast cereal containing psyllium fibre
PubMed ID: 7830631
Daily psyllium-containing cereal produced modest but significant reductions in total and LDL cholesterol.
- Long-term treatment of hypercholesterolemia with dietary fiber
PubMed ID: 7985708
~20 g/day mixed fibers over ~9–12 months gave modest sustained reductions in total and LDL cholesterol.
- Long-term comparison of three dietary prescriptions in the treatment of NIDDM
PubMed ID: 8112194
Dietary prescriptions including a high-carb/high-fiber option were associated with sustained reductions in LDL cholesterol.
- Lipid profiles after the daily consumption of an oat-based cereal: a controlled crossover trial
PubMed ID: 8279405
Oat‑based soluble fiber cereal produced small but significant reductions in total and LDL cholesterol in a 64‑person crossover trial.
- Soluble fiber enhances the hypocholesterolemic effect of the step I diet in childhood
PubMed ID: 8586774
Psyllium added to a low-fat diet in children significantly lowered total and LDL cholesterol — direct, strong evidence.
- [Evaluation of the action of glucomannan on metabolic parameters and on the sensation of satiation in overweight and obese patients]
PubMed ID: 7796558
Glucomannan with calorie restriction produced superior cholesterol outcomes compared with diet alone (supportive evidence).
- Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men
PubMed ID: 7872224
Konjac glucomannan produced clear reductions in total cholesterol (−10%) and LDL (−7.2%) in a crossover RCT—strong direct evidence.
- von Willebrand factor, a possible indicator of endothelial cell damage, decreases during long-term compliance with a lipid-lowering diet
PubMed ID: 7782727
3‑year lipid‑lowering diet that included increased fiber reduced total and LDL cholesterol, though fiber was one of several dietary changes.
- Effect of psyllium in hypercholesterolemia at two monounsaturated fatty acid intakes
PubMed ID: 9129487
Psyllium produced ~12–15% LDL reductions in hyperlipidemic subjects — strong evidence for cholesterol lowering.
- Effects of lowering fat and increasing dietary fiber on fasting and postprandial plasma lipids in hypercholesterolemic subjects consuming a mixed Mediterranean-Western diet
PubMed ID: 9394698
Adding substantial dietary fiber to a low‑fat diet produced larger decreases in total and LDL cholesterol compared with low‑fat alone—strong direct evidence.
- Long-term effect of soluble-fiber foods on postprandial fat metabolism in dyslipidemic subjects with apo E3 and apo E4 genotypes
PubMed ID: 9280177
Well-controlled crossover: long-term soluble-fiber foods significantly lowered fasting total cholesterol and increased fecal bile acids.
- Intestinal fatty acid-binding protein variation associated with variation in the response of plasma lipoproteins to dietary fibre
PubMed ID: 9373766
Genetic-subgroup analysis: soluble-fiber diet produced larger decreases in total and LDL cholesterol in FABP2 T54 carriers—supports cholesterol-lowering effect.
- Lipid- and glucose-lowering efficacy of Plantago Psyllium in type II diabetes
PubMed ID: 9747644
Psyllium 5 g TID lowered LDL and triglycerides and raised HDL in T2D RCT—direct lipid benefits.
- Full-fat rice bran and oat bran similarly reduce hypercholesterolemia in humans
PubMed ID: 9566995
Oat bran and rice bran both lowered serum cholesterol vs placebo in a randomized trial—bran (fiber) mediated lipid lowering.
- Ispaghula husk in the treatment of hypercholesterolaemia: a double-blind controlled study
PubMed ID: 10201553
Large double‑blind RCT: ispaghula (psyllium) 7–10.5 g/day produced 8–13% LDL reductions over months—strong direct evidence.
- Long-term effects of consuming foods containing psyllium seed husk on serum lipids in subjects with hypercholesterolemia
PubMed ID: 9497178
24‑week psyllium RCT showed modest but consistent LDL lowering (~5.3% vs control) — direct evidence for cholesterol reduction.
- The effect of a low-fat, high-carbohydrate diet on serum high density lipoprotein cholesterol and triglyceride
PubMed ID: 9805219
Dietary substitution to a fibre‑rich diet produced substantial total and LDL cholesterol reductions (~14% and ~18%) — supports cholesterol lowering.
- Cookies enriched with psyllium or oat bran lower plasma LDL cholesterol in normal and hypercholesterolemic men from Northern Mexico
PubMed ID: 9853540
8‑week feeding trial with psyllium and oat bran produced large LDL decreases (−22.6% and −26%) — strong evidence for LDL lowering.
- Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia
PubMed ID: 10500014
Psyllium supplementation lowered total cholesterol and reduced LDL (trend) in men with T2D.
- Cholesterol lowering with high-viscosity hydroxypropylmethylcellulose
PubMed ID: 10569330
Large randomized trial: HPMC (high-viscosity soluble fiber-like) produced dose-dependent LDL and total cholesterol reductions.
- Long-term blood cholesterol-lowering effects of a dietary fiber supplement
PubMed ID: 10429748
Randomized, placebo‑controlled trial: multi-fiber supplement (20 g/d) produced significant and sustained LDL reductions over months—strong direct evidence for fiber lowering cholesterol.
- Combined effect of vegetable protein (soy) and soluble fiber added to a standard cholesterol-lowering diet
PubMed ID: 10381159
Combined dietary intervention (increased soy protein + doubled soluble fiber) produced modest reductions in total cholesterol, LDL, and apoB—fiber likely contributed though intervention was multi-component.
- Consumption of oat milk for 5 weeks lowers serum cholesterol and LDL cholesterol in free-living men with moderate hypercholesterolemia
PubMed ID: 10749030
Randomized crossover: oat (beta‑glucan) milk lowered total and LDL cholesterol ≈6%—direct, high‑relevance evidence for cholesterol lowering by a soluble fiber.
- A study to assess the effect of dietary supplementation with soluble fibre (Minolest) on lipid levels in normal subjects with hypercholesterolaemia
PubMed ID: 10497668
Soluble fiber (guar/psyllium) modestly but significantly lowered total and LDL cholesterol over 3 months in an RCT.
- High-molecular-weight hydroxypropylmethylcellulose taken with or between meals is hypocholesterolemic in adult men
PubMed ID: 10867040
Randomized trial of 5 g/day high‑molecular‑weight HPMC produced consistent total and LDL cholesterol reductions — strong direct evidence that viscous fiber lowers cholesterol.
- Rye bread decreases serum total and LDL cholesterol in men with moderately elevated serum cholesterol
PubMed ID: 10720164
Rye-bread (fiber-rich) intervention lowered total and LDL cholesterol, particularly in men.
- Sex and hormonal status influence plasma lipid responses to psyllium
PubMed ID: 11566640
Psyllium supplementation (15 g/day) produced modest but consistent LDL reductions (−7 to −9%).
- An oat-containing hypocaloric diet reduces systolic blood pressure and improves lipid profile beyond effects of weight loss in men and women
PubMed ID: 11340101
Oat-containing diet produced significant reductions in total and LDL cholesterol versus control—strong direct evidence for cholesterol-lowering effect.
- High-soluble-fiber foods in conjunction with a telephone-based, personalized behavior change support service result in favorable changes in lipids and lifestyles after 7 weeks
PubMed ID: 11985406
A 7‑week high‑soluble‑fiber foods program produced modest but significant reductions in total and LDL cholesterol and triglycerides.
- Agrarian diet improves metabolic health in HIV-positive men with Prevotella-rich microbiomes: results from a randomized trial
PubMed ID: 41294355
Short agrarian (high‑fibre) diet lowered LDL‑C, particularly in Prevotella‑rich microbiomes.
- Comparison of Low-Gluten Diets Rich in Oats or Rice-A 6-Week Randomized Clinical Trial With Metabolically Challenged Volunteers
PubMed ID: 40331457
Oat‑rich (higher fibre) diet produced significant LDL and total cholesterol reductions vs rice diet.
- Supplementing the standard diet with brown rice bran powder might effectively improve the metabolic syndrome characteristics and antioxidant status: an open label randomized controlled trial
PubMed ID: 39775811
Brown rice bran RCT produced a significant LDL‑cholesterol reduction.
- Effects of defatted rice bran-fortified bread on gut microbiome, cardiovascular risk, gut discomfort, wellbeing and gut physiology in healthy adults with low dietary fibre intake
PubMed ID: 40127766
Defatted rice‑bran‑fortified bread increased HDL and improved total cholesterol/HDL ratio after crossover intervention.
- Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study
PubMed ID: 40057729
Personalized high‑fiber + improved‑fat diet produced 14–16% LDL‑C reductions, strong evidence for cholesterol lowering.
- A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial
PubMed ID: 39843443
Legume‑rich (high‑fiber) intervention produced statistically significant LDL and total cholesterol reductions.
- Evaluating the Effects of Corn Flour Product Consumption on Cardiometabolic Outcomes and the Gut Microbiota in Adults with Elevated Cholesterol: A Randomized Crossover
PubMed ID: 38880174
Corn bran enrichment lowered LDL modestly in adults with elevated LDL in a crossover trial.
- A four-week dietary intervention with mycoprotein-containing food products reduces serum cholesterol concentrations in community-dwelling, overweight adults: A randomised controlled trial
PubMed ID: 38306892
Four weeks of substituting mycoprotein for meat/fish modestly lowered total cholesterol in overweight hypercholesterolemic adults.
- Twelve Weeks of Daily Lentil Consumption Improves Fasting Cholesterol and Postprandial Glucose and Inflammatory Responses-A Randomized Clinical Trial
PubMed ID: 38337705
Daily lentils lowered fasting total and LDL cholesterol over 12 weeks vs control.
- Type 3 resistant starch from Canna edulis reduce lipid levels in patients with mild hyperlipidemia through altering gut microbiome: A double- blind randomized controlled trial
PubMed ID: 38825157
Resistant starch (20 g/day) significantly decreased total cholesterol, LDL‑C and non‑HDL‑C vs placebo in a 12‑week RCT.
- A Comparison of Dry Bean and Pea Consumption on Serum Cholesterol: A Randomized Controlled Trial in Adults with Mild Hypercholesterolemia
PubMed ID: 39357673
Randomized bean (pulse) intervention (~120 g/day) lowered LDL, non‑HDL and total cholesterol vs rice after 6 weeks.
- The Portfolio Diet and HbA1c in Adults Living with Type 2 Diabetes Mellitus: A Patient-Level Pooled Analysis of Two Randomized Dietary Trials
PubMed ID: 39275135
Pooled analysis showed better adherence to the Portfolio diet (including viscous fibres) associated with modest LDL‑C reductions in T2D patients.
- Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial
PubMed ID: 36599304
Phenotype‑tailored diets (with fiber emphasis) improved triglycerides and inflammation—favorable lipid effects relevant to cholesterol management.
- Effects of an Eating Pattern Including Colorful Fruits and Vegetables on Management of Gestational Diabetes: A Randomized Controlled Trial
PubMed ID: 37630814
Dietary fruit/veg intervention in gestational diabetes raised HDL, a positive heart‑lipid change.
- Dietary Supplementation with Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), Reduces Visceral Fat and Hyperlipidemia in Inhabitants of a Rural Community in Mexico
PubMed ID: 36004709
Mushroom supplementation improved total cholesterol in women in a small trial—suggestive benefit.
- Tapioca Resistant Maltodextrin as a Carbohydrate Source of Oral Nutrition Supplement (ONS) on Metabolic Indicators: A Clinical Trial
PubMed ID: 35267892
Resistant maltodextrin produced modest LDL reductions over 12 weeks in small samples.
- Oats Lower Age-Related Systemic Chronic Inflammation (iAge) in Adults at Risk for Cardiovascular Disease
PubMed ID: 36364734
Oat β‑glucan (3 g/day) reduced LDL/inflammaging score in elevated‑risk subgroup—strong evidence for LDL lowering.
- Facilitating a high-quality dietary pattern induces shared microbial responses linking diet quality, blood pressure, and microbial sterol metabolism in caregiver-child dyads
PubMed ID: 36457073
High‑fiber diet increased fecal cholesterol excretion—mechanistic support for cholesterol lowering potential.
- Increasing the diversity of dietary fibers in a daily-consumed bread modifies gut microbiota and metabolic profile in subjects at cardiometabolic risk
PubMed ID: 35311446
Multi‑fiber bread decreased LDL‑C by −0.36 mM and total cholesterol by −0.42 mM—direct cholesterol‑lowering effect.
- Diverging metabolic effects of 2 energy-restricted diets differing in nutrient quality: a 12-week randomized controlled trial in subjects with abdominal obesity
PubMed ID: 35102369
Higher‑quality (higher‑fiber) energy‑restricted diet produced superior reductions in fasting triglycerides and total cholesterol.
- Consuming a Protein and Fiber-Based Supplement Preload Promotes Weight Loss and Alters Metabolic Markers in Overweight Adults in a 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 35212740
HPF supplement produced significant reductions in total cholesterol and LDL vs control in RCT (fiber part of the product).
- Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention-Association with Metabolic Profile from Childhood to Adulthood
PubMed ID: 33562015
Children/adolescents meeting fiber-containing dietary targets had lower LDL-related lipids and apolipoprotein B — strong evidence linking fiber intake and cholesterol improvements.
- Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial
PubMed ID: 33861390
Psyllium reduced small dense LDL in obese adolescents — direct lipid‑lowering evidence from soluble fibre.
- Effect of a functional fibre supplement on glycemic control when added to a year-long medically supervised weight management program in adults with type 2 diabetes
PubMed ID: 32642971
PGX fiber reduced LDL at 16 and 26 weeks in the trial (evidence of cholesterol‑lowering effect).
- Replacing Animal-Based Proteins with Plant-Based Proteins Changes the Composition of a Whole Nordic Diet-A Randomised Clinical Trial in Healthy Finnish Adults
PubMed ID: 32231103
A 12‑week randomized trial replacing animal with plant proteins increased fiber intake and produced significant reductions in total and LDL cholesterol.
- Human clinical trial to assess the effect of consumption of multigrain Indian bread on glycemic regulation in type 2 diabetic participants
PubMed ID: 33006193
Multigrain (millet) flatbread intervention lowered LDL cholesterol in people with type 2 diabetes (direct cholesterol-lowering evidence).
- Carbohydrate quality changes and concurrent changes in cardiovascular risk factors: a longitudinal analysis in the PREDIMED-Plus randomized trial
PubMed ID: 31868210
Higher carbohydrate quality including more fiber was associated with favorable lipid changes in a large trial.
- Effects of High-Fiber Biscuits on Lipid and Anthropometric Profile of Patients with Type 2 Diabetes
PubMed ID: 33612630
High-fibre biscuits in T2D produced substantial reductions in total and LDL cholesterol over 4 weeks.
- Two apples a day lower serum cholesterol and improve cardiometabolic biomarkers in mildly hypercholesterolemic adults: a randomized, controlled, crossover trial
PubMed ID: 31840162
Two whole apples daily lowered total and LDL cholesterol in a randomized crossover trial (fiber + polyphenols intervention).
- A Whole-Diet Approach Affects Not Only Fasting but Also Postprandial Cardiometabolic Risk Markers in Overweight and Obese Adults: A Randomized Controlled Trial
PubMed ID: 33096554
Whole-diet (higher fiber) intervention decreased LDL and total cholesterol vs Western diet.
- Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort
PubMed ID: 32369545
Observational evidence links higher soluble fiber to lower CVD and lower cholesterol-related outcomes; supports cholesterol-lowering role.
- Weight loss at your fingertips: personalized nutrition with fasting glucose and insulin using a novel statistical approach
PubMed ID: 30967642
Whole-diet high in fiber/whole grains (NND) can support cardiometabolic risk reduction including lipids, inferred from weight-loss effects.
- Effect of High Fiber Cereal Intake on Satiety and Gastrointestinal Symptoms during Ramadan
PubMed ID: 31027300
High-fiber cereal attenuated rises in total and LDL cholesterol during Ramadan (20-day RCT).
- Snack selection influences glucose metabolism, antioxidant capacity and cholesterol in healthy overweight adults: A randomized parallel arm trial
PubMed ID: 30952505
Dried plum snack decreased LDL‑C in an 8‑week randomized trial vs refined snack.
- No Effect of Glucomannan on Body Weight Reduction in Children and Adolescents with Overweight and Obesity: A Randomized Controlled Trial
PubMed ID: 31036412
Glucomannan reduced total and LDL cholesterol in children in a randomized trial.
- Ameliorating Effects of Four-Week Fiber-Multivitamin Combination Treatment on Low-Density Lipoprotein Cholesterol, Total Cholesterol, and Apolipoprotein B Profiles in Hypercholesterolemic Participants
PubMed ID: 30380357
A fiber‑plus‑multivitamin product produced a moderate, statistically significant LDL and ApoB reduction vs placebo; multi‑ingredient limits attribution to fiber alone.
- Success in Achieving the Targets of the 20-Year Infancy-Onset Dietary Intervention: Association With Insulin Sensitivity and Serum Lipids
PubMed ID: 30072407
Dietary targets including higher whole-grain/fruit/veg/fiber were associated with lower LDL and non-HDL cholesterol in a large youth trial.
- Effects of Quinoa (Chenopodium quinoa Willd.) Consumption on Markers of CVD Risk
PubMed ID: 29914146
Quinoa bread produced a modest LDL decrease after 4 weeks.
- Impact of Diets Rich in Whole Grains and Fruits and Vegetables on Cardiovascular Risk Factors in Overweight and Obese Women: A Randomized Clinical Feeding Trial
PubMed ID: 29702040
Whole-grain–rich diet produced favorable changes in triglycerides and HDL and improved other lipid markers vs comparator diets.
- Improvement in cardiometabolic risk markers following a multifunctional diet is associated with gut microbial taxa in healthy overweight and obese subjects
PubMed ID: 29098426
High‑fiber multifunctional diet produced marked LDL (−34%) and total cholesterol (−26%) reductions in overweight adults.
- The Effect of a Diet Moderately High in Protein and Fiber on Insulin Sensitivity Measured Using the Dynamic Insulin Sensitivity and Secretion Test (DISST)
PubMed ID: 29186908
Higher-protein/higher-fiber diet produced improvements in total and LDL cholesterol (reported modest lipid benefits).
- Effect on Insulin, Glucose and Lipids in Overweight/Obese Australian Adults of 12 Months Consumption of Two Different Fibre Supplements in a Randomised Trial
PubMed ID: 28146065
PGX reduced total cholesterol and LDL substantially at 3 months in overweight/obese adults.
- Co-administration of a konjac-based fibre blend and American ginseng (Panax quinquefolius L.) on glycaemic control and serum lipids in type 2 diabetes: a randomized controlled, cross-over clinical trial
PubMed ID: 28687934
Konjac intervention lowered LDL‑C and non‑HDL‑C in people with type 2 diabetes.
- Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study
PubMed ID: 28376899
Oat β‑glucan 3 g/day produced significant reductions in total cholesterol and LDL‑C in mildly hypercholesterolemic adults.
- [Effect of simvastatin plus inulin in comparison with simvastatin plus ezetimibe on the treatment of mixed dyslipidemia]
PubMed ID: 27792720
12‑week RCT: adding inulin to simvastatin produced substantial reductions in TC and LDL (clinically meaningful), directly supporting cholesterol‑lowering benefit of this fibre.
- Effects of oat bran and nutrition counseling on the lipid and glucose profile and anthropometric parameters of hypercholesterolemia patients
PubMed ID: 27019267
Oat bran 40 g/day plus counseling lowered LDL and total cholesterol—strong evidence that concentrated oat fiber can help lower cholesterol.
- Sex differences in food choices, adherence to dietary recommendations and plasma lipid profile in type 2 diabetes - The TOSCA.IT study
PubMed ID: 27212622
Large observational study: adherence to fiber recommendations associated with lower LDL in adults with T2D—supportive epidemiologic evidence.
- Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial
PubMed ID: 27919453
Tartary buckwheat reduced total and LDL cholesterol modestly over 4 weeks (whole‑food intervention with fiber and flavonoids).
- Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial)
PubMed ID: 27733151
Psyllium is established to reduce LDL cholesterol in other studies; trial showed cardiometabolic benefits though cholesterol not reported in summary.
- Short- and Long-Term Effects of Wholegrain Oat Intake on Weight Management and Glucolipid Metabolism in Overweight Type-2 Diabetics: A Randomized Control Trial
PubMed ID: 27618090
Oats are well known to lower LDL; this RCT showed glycaemic and weight benefits supporting cardiometabolic profile.
- Effects of total fibre or resistant starch-rich diets within lifestyle intervention in obese prediabetic adults
PubMed ID: 25588971
Resistant starch‑focused advice produced larger decreases in total and non‑HDL cholesterol than general advice in the trial.
- Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial
PubMed ID: 26529006
Infant fructan supplementation (with probiotic) was associated with lower triglycerides and LDL and higher HDL in that trial.
- A multifunctional diet improves cardiometabolic-related biomarkers independently of weight changes: an 8-week randomized controlled intervention in healthy overweight and obese subjects
PubMed ID: 26370118
Multifunctional diet including viscous fibers markedly lowered total and LDL cholesterol independent of weight loss.
- Influence of dietary fat and carbohydrates proportions on plasma lipids, glucose control and low-grade inflammation in patients with type 2 diabetes-The TOSCA.IT Study
PubMed ID: 26303195
Higher relative fiber intake associated with better plasma lipids in people with T2D in this observational analysis.
- Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity
PubMed ID: 24997634
Mediterranean-style diet (with higher fiber) produced clinically meaningful lipid improvements (HDL up, TG down).
- Resistant starch type 4-enriched diet lowered blood cholesterols and improved body composition in a double blind controlled cross-over intervention
PubMed ID: 24478107
RS4-enriched flour significantly lowered total and non‑HDL cholesterol (strong direct evidence).
- Intensive low-glycaemic-load dietary intervention for the management of glycaemia and serum lipids among women with gestational diabetes: a randomized control trial
PubMed ID: 25222105
Low‑GL/higher‑fiber diet improved some lipid measures in women with gestational diabetes (supportive for cholesterol/lipid benefits).
- Changes in visceral adiposity and serum cholesterol with a novel viscous polysaccharide in Japanese adults with abdominal obesity
PubMed ID: 23512917
PGX (viscous fiber) significantly reduced total and LDL cholesterol in a randomized placebo‑controlled trial.
- Lifestyle intervention reduces body weight and improves cardiometabolic risk factors in worksites
PubMed ID: 23426035
Multicomponent intervention including high-fiber diet reduced total cholesterol alongside weight loss — consistent with fiber-associated lipid benefits (but not isolated).
- A CHO/fibre diet reduces and a MUFA diet increases postprandial lipaemia in type 2 diabetes: no supplementary effects of low-volume physical training
PubMed ID: 24132660
Carbohydrate+fiber diet decreased postprandial cholesterol iAUC vs MUFA diet in T2D — direct lipid-related benefit relevant to cholesterol handling.
- A high-fibre bean-rich diet versus a low-carbohydrate diet for obesity
PubMed ID: 23627924
High‑fiber bean diet decreased LDL and total cholesterol more than low‑carb diet (RCT evidence).
- Soy fiber improves weight loss and lipid profile in overweight and obese adults: a randomized controlled trial
PubMed ID: 23881774
Soy‑fiber biscuits reduced LDL cholesterol in overweight adults (small RCT).
- Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial
PubMed ID: 22848584
Psyllium (6 g/d) lowered LDL cholesterol in adolescents at cardiometabolic risk.
- Whole grain compared with refined wheat decreases the percentage of body fat following a 12-week, energy-restricted dietary intervention in postmenopausal women
PubMed ID: 22357746
Whole‑grain (higher fiber) prevented LDL increases seen with refined wheat during weight‑loss dieting.
- Persimmon fruit tannin-rich fiber reduces cholesterol levels in humans
PubMed ID: 23171573
Tannin‑rich persimmon fiber produced dose‑dependent reductions in total and LDL cholesterol in adults.
- Chitin-glucan fiber effects on oxidized low-density lipoprotein: a randomized controlled trial
PubMed ID: 22948945
Chitin-glucan (4.5 g/day) lowered oxidized LDL in hypercholesterolemic adults—relevant to lipid/atherosclerotic risk, though changes in LDL-C were limited.
- Cocoa, hazelnuts, sterols and soluble fiber cream reduces lipids and inflammation biomarkers in hypertensive patients: a randomized controlled trial
PubMed ID: 22383996
Product containing soluble fiber and phytosterols lowered LDL, but effects are confounded by multiple active ingredients.
- Randomized controlled trial of oatmeal consumption versus noodle consumption on blood lipids of urban Chinese adults with hypercholesterolemia
PubMed ID: 22866937
Instant oatmeal (soluble fiber) significantly lowered total and LDL cholesterol vs control—strong direct evidence.
- Eating buckwheat cookies is associated with the reduction in serum levels of myeloperoxidase and cholesterol: a double blind crossover study in day-care centre staffs
PubMed ID: 21931228
Two‑week buckwheat cookie crossover showed reductions in total cholesterol (food‑based fiber source, modest effect).
- Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults
PubMed ID: 21414045
High‑viscosity soluble fiber reduced total, HDL and LDL cholesterol measures compared with inulin control—direct lipid lowering evidence.
- Effect of a dietary portfolio of cholesterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia: a randomized controlled trial
PubMed ID: 21862744
6‑month RCT 'portfolio' diet including viscous fibres produced ~13% LDL reduction vs ~3% control—strongly supports cholesterol‑lowering role of viscous fibre as part of the diet.
- Effects of lifestyle modification on oxidized LDL, reactive oxygen species production and endothelial cell viability in patients with coronary artery disease
PubMed ID: 20416290
High-fiber-containing lifestyle program reduced serum lipids in CAD patients, but effect cannot be solely attributed to fiber.
- [Randomized clinical trial with a inulin enriched cookie on risk cardiovascular factor in obese patients]
PubMed ID: 20204256
Daily inulin (3 g) lowered total and LDL cholesterol in obese subjects over one month (small RCT, short duration).
- Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial
PubMed ID: 20413122
Psyllium 14 g/d produced clinically meaningful LDL and triglyceride reductions versus placebo—strong, directly relevant evidence.
- The beneficial effects of α-cyclodextrin on blood lipids and weight loss in healthy humans
PubMed ID: 21127475
α‑Cyclodextrin produced statistically significant reductions in total cholesterol (~−5.3%) and LDL (~−6.7%) in overweight adults.
- Insoluble carob fiber rich in polyphenols lowers total and LDL cholesterol in hypercholesterolemic sujects
PubMed ID: 20094802
Carob fiber RCT produced large reductions in total and LDL cholesterol over 4 weeks (strong direct evidence).
- Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods
PubMed ID: 20102847
Oat β‑glucan cereal during weight loss lowered LDL and total cholesterol significantly vs control.
- A high legume low glycemic index diet improves serum lipid profiles in men
PubMed ID: 20734238
Well-controlled crossover feeding study: legume-rich, high-fermentable-fibre diet reduced total cholesterol and LDL by ≈10% over 4 weeks.
- Dietary fiber does not displace energy but is associated with decreased serum cholesterol concentrations in healthy children
PubMed ID: 20071642
Cohort in children showed higher dietary fiber linked to lower serum total cholesterol — good long-term evidence.
- NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
PubMed ID: 21164548
NUTRIOSE RCT decreased total/LDL/VLDL/TG and increased HDL — direct evidence of cholesterol improvement.
- Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk
PubMed ID: 19289389
Higher fiber intake associated with improvements in total cholesterol in a large free‑living intervention.
- Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial
PubMed ID: 19196472
PGX (viscous fiber) caused modest but statistically significant reductions in total and LDL cholesterol in a randomized trial.
- Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines
PubMed ID: 18416823
Raisin intake lowered LDL cholesterol and some inflammatory markers in middle‑aged adults — supportive evidence from a fiber‑rich food.
- Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women
PubMed ID: 18328014
Flaxseed consumption for 3 months produced modest, clinically relevant reductions in total and LDL cholesterol in postmenopausal women.
- Efficacy of lifestyle changes in modifying practical markers of wellness and aging
PubMed ID: 18383987
Multi‑component lifestyle including added fiber improved TC:HDL ratio over 10 weeks—cardiometabolic benefit observed though fiber not sole factor.
- Chickpeas may influence fatty acid and fiber intake in an ad libitum diet, leading to small improvements in serum lipid profile and glycemic control
PubMed ID: 18502235
Direct dietary intervention with canned chickpeas (↑fiber ≈+6.8 g/d) produced modest but significant reductions in total and LDL cholesterol after 12 weeks.
- Effects of grape antioxidant dietary fiber in cardiovascular disease risk factors
PubMed ID: 18485668
Grape-derived fiber+antioxidant product reduced total and LDL cholesterol substantially (esp. in hypercholesterolemics).
- Comparison of a dietary portfolio diet of cholesterol-lowering foods and a statin on LDL particle size phenotype in hypercholesterolaemic participants
PubMed ID: 17663803
A diet portfolio including soluble fiber produced marked LDL reductions comparable to a statin—strong evidence that soluble fiber contributes to cholesterol lowering.
- Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial
PubMed ID: 18031592
Soluble-fiber supplementation significantly lowered LDL in the trial population, supporting a cholesterol‑lowering effect.
- Randomised study to compare the efficacy and safety of isapgol plus atorvastatin versus atorvastatin alone in subjects with hypercholesterolaemia
PubMed ID: 17824470
Ispaghula (psyllium) plus atorvastatin produced significantly greater LDL‑C lowering than atorvastatin alone in a 12‑week randomized trial.
- The benefits of early intervention in obese diabetic patients with FBCx: a new dietary fibre
PubMed ID: 17013969
FBCx reduced total cholesterol in a hypertriglyceridemic subgroup (randomized trial) — cholesterol benefit in a subgroup.
- High-fiber oat cereal compared with wheat cereal consumption favorably alters LDL-cholesterol subclass and particle numbers in middle-aged and older men
PubMed ID: 12145006
Twelve weeks of high‑fiber oat cereal lowered small dense LDL, LDL particle number, and improved LDL:HDL ratio vs wheat—strong direct evidence.
- Sex and hormonal status influence the effects of psyllium on lipoprotein remodeling and composition
PubMed ID: 11912561
Psyllium 15 g/day lowered LDL by ~8% overall (sex-specific effects on TG/insulin noted).
- Soy in hypercholesterolaemia: a double-blind, placebo-controlled trial
PubMed ID: 11965512
Soy supplement containing soy fiber modestly lowered total and LDL cholesterol over 6 weeks.
- Dietary counselling for dyslipidemia in primary care: results of a randomized trial
PubMed ID: 12493139
Psyllium-containing cereal improved LDL and TC/HDL-C ratio over 6 months (modest effect).
- Dietary patterns and nutrient intakes of 7-year-old children taking part in an atherosclerosis prevention project in Finland
PubMed ID: 11985408
Long-term dietary counseling shifted children's eating toward higher-fibre foods and was associated with lower cholesterol—supportive evidence for fibre reducing cholesterol in a population setting.
- Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control?
PubMed ID: 11978259
Whole-grain oat cereal trial showed large reductions in total and LDL cholesterol—strong direct evidence that oat fibre helps lower cholesterol.
- The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity
PubMed ID: 14633807
Lifestyle intervention including more fiber improved lipid measures (reported improvement though not solely attributable to fiber).
- Carob pulp preparation rich in insoluble fibre lowers total and LDL cholesterol in hypercholesterolemic patients
PubMed ID: 14569404
RCT: carob (insoluble) fiber produced a statistically significant LDL reduction (~10.5%) in hypercholesterolemic patients.
- Effects of plant-based diets high in raw or roasted almonds, or roasted almond butter on serum lipoproteins in humans
PubMed ID: 12805245
Almond supplementation in a heart-healthy diet lowered LDL-cholesterol in hypercholesterolemic adults; almonds contain fiber among other lipid-modifying components (food trial; not fiber-only).
- Isolated soya protein with standardised levels of isoflavones, cotyledon soya fibres and soya phospholipids improves plasma lipids in hypercholesterolaemia: a double-blind, placebo-controlled trial of a yoghurt formulation
PubMed ID: 15005825
Soy-containing product with fiber lowered LDL, but multiple active components confound attribution to fiber alone.
- Effect of soluble fiber intake in lipid and glucose levels in healthy subjects: a randomized clinical trial
PubMed ID: 15163472
Soluble fiber produced ~12.8% LDL reduction in a randomized trial (strong evidence for LDL lowering).
- Supplementation of wheat fibre can improve risk profile in patients with dysmetabolic cardiovascular syndrome
PubMed ID: 15187818
Wheat fiber reduced total and LDL cholesterol in metabolic-risk patients (direct lipid benefit).
- A double-blind placebo-controlled clinical trial compares the cholesterol-lowering effects of two different soy protein preparations in hypercholesterolemic subjects
PubMed ID: 15309422
Soy product with added soy fibre/phospholipids produced larger reductions in total and LDL cholesterol versus soy protein alone—direct lipid benefit attributed in part to added fibre.
- Dietary fiber intake and risk factors for cardiovascular disease in French adults
PubMed ID: 16332650
Observational data: higher total and insoluble fiber linked with lower total cholesterol and other lipid markers.
- Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants
PubMed ID: 15699225
Portfolio diet including viscous fiber lowered LDL nearly as much as lovastatin (randomized crossover), though fiber was one of several active components.
- Effects of agar (kanten) diet on obese patients with impaired glucose tolerance and type 2 diabetes
PubMed ID: 15642074
Agar supplementation modestly reduced total cholesterol vs control in obese/IGT/T2DM patients.
- Effect of combining psyllium fiber with simvastatin in lowering cholesterol
PubMed ID: 15911730
Psyllium (15 g/d) added to simvastatin produced a modest but significant additional LDL and apoB reduction.
- Lupin kernel fibre-enriched foods beneficially modify serum lipids in men
PubMed ID: 15508014
Lupin kernel fiber (17–30 g/d) significantly lowered total and LDL cholesterol in men.
- Effect of dietary supplementation with glucomannan on plasma total cholesterol and low density lipoprotein cholesterol in hypercholesterolemic children
PubMed ID: 15955465
Glucomannan added to diet in hypercholesterolemic children significantly lowered total and LDL cholesterol versus control in an RCT.
- Dietary supplementation with chickpeas for at least 5 weeks results in small but significant reductions in serum total and low-density lipoprotein cholesterols in adult women and men
PubMed ID: 17191025
Chickpea supplementation for ≥5 weeks slightly but significantly lowered total and LDL cholesterol vs wheat diet.
- Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study
PubMed ID: 17098085
Lifestyle program that increased fiber contributed to cardiometabolic risk reduction; cholesterol effects likely multifactorial.
- A combination therapy including psyllium and plant sterols lowers LDL cholesterol by modifying lipoprotein metabolism in hypercholesterolemic individuals
PubMed ID: 16988115
Psyllium-containing cookies produced clinically meaningful LDL and total cholesterol reductions (sterol confounder noted).
- Effect of combining viscous fibre with lovastatin on serum lipids in normal human subjects
PubMed ID: 17935545
Psyllium (with lovastatin) produced substantial LDL and TC reductions; psyllium alone had modest effects.
- Effectiveness of a lifestyle intervention on metabolic syndrome. A randomized controlled trial
PubMed ID: 17922167
Lifestyle intervention that increased fiber reduced hypertriglyceridemia and improved metabolic risk profile linked to CVD risk.
- Hydroxypropylmethylcellulose significantly lowers blood cholesterol in mildly hypercholesterolemic human subjects
PubMed ID: 17882138
Well-controlled randomized trials: viscous HPMC produced dose-dependent, clinically meaningful LDL and total cholesterol reductions.
- Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber on plasma low-density lipoprotein cholesterol and other clinical markers of cardiovascular risk
PubMed ID: 17161227
Konjac-mannan (soluble fiber) produced substantial LDL-C reductions (14–18%) in randomized trial.
Metabolism (215)
- Influence of two guar preparations on glycosylated hemoglobin, total cholesterol and triglycerides in patients with diabetes mellitus
PubMed ID: 1335441
Guar fibre lowered HbA1 and cholesterol in diabetics—metabolic improvements in glycaemic control.
- A dietary fibre supplement in the treatment of mild hypertension. A randomized, double-blind, placebo-controlled trial
PubMed ID: 1313484
RCT of fibre supplement showed reductions in fasting insulin, diastolic BP and body weight—direct metabolic support.
- Dietary modulators of lipid metabolism in the Indian diet-heart study (I.D.H.S.)
PubMed ID: 1316885
Diet higher in complex carbs and fibre improved lipids and triglycerides — supports metabolic health.
- Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of one year follow up
PubMed ID: 1586782
Comprehensive post-MI diet including soluble fiber led to weight loss and lipid improvements — metabolic support though multifactorial.
- [Chronic use of glucomannan in the dietary treatment of severe obesity]
PubMed ID: 1313163
Glucomannan improved fat loss and glucose tolerance when added to a hypocaloric diet — direct metabolic effects.
- Soluble fiber enhances the hypocholesterolemic effect of the step I diet in childhood
PubMed ID: 8586774
Psyllium lowered LDL/total cholesterol in children — relevant to metabolic risk profile.
- [Evaluation of the action of glucomannan on metabolic parameters and on the sensation of satiation in overweight and obese patients]
PubMed ID: 7796558
Glucomannan combined with calorie restriction improved weight and blood glucose in the trial—metabolic benefit.
- Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men
PubMed ID: 7872224
Konjac glucomannan produced substantial reductions in triglycerides (−23%) and total/LDL cholesterol, indicating metabolic effects.
- Effects of dietary fat and fiber on plasma and urine androgens and estrogens in men: a controlled feeding study
PubMed ID: 8942407
Dietary fat and fiber changes altered sex‑hormone excretion and testosterone measures, showing metabolic/endocrine consequences of dietary composition (fiber not isolated).
- Improved quality of life in patients with generalized cardiovascular metabolic disease on a prepared diet
PubMed ID: 8942420
Prepared RDA diet including fiber improved metabolic risk markers (HbA1c, lipids) though attribution not exclusive to fiber.
- Lipid- and glucose-lowering efficacy of Plantago Psyllium in type II diabetes
PubMed ID: 9747644
Psyllium improved fasting glucose and lipids in T2D, indicating metabolic benefits in humans.
- Intense nonpharmacological intervention in subjects with multiple cardiovascular risk factors: decreased fasting insulin levels but only a minor effect on plasma plasminogen activator inhibitor activity
PubMed ID: 9550533
Intensive lifestyle program including high‑fiber diet lowered fasting insulin and BMI — supports metabolic improvements though multi‑component.
- Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia
PubMed ID: 10500014
Psyllium reduced postprandial glucose (all-day and postlunch), indicating metabolic benefit.
- The Finnish Diabetes Prevention Study
PubMed ID: 10889804
Lifestyle program with increased fiber produced sustained improvements in glucose tolerance, weight and triglycerides (multicomponent but metabolically beneficial).
- Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
PubMed ID: 11333990
Lifestyle program (incl. more fiber) halved diabetes incidence — strong multicomponent evidence for metabolic support, though fibre-specific contribution unclear.
- Consumption of whole grain and legume powder reduces insulin demand, lipid peroxidation, and plasma homocysteine concentrations in patients with coronary artery disease: randomized controlled clinical trial
PubMed ID: 11742886
Higher-fiber whole-grain/legume powder reduced fasting glucose/insulin and AUCs — direct metabolic improvement.
- Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control?
PubMed ID: 11978259
Whole-grain oats reduced cholesterol and glucose and allowed BP med reduction—clear positive metabolic effects linked to oat fibre.
- The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity
PubMed ID: 14633807
Large intensive lifestyle program including higher fiber improved glycemia and lipids over 3 years.
- Effects of dietary intervention on IGF-I and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial
PubMed ID: 12947426
5-month dietary intervention with higher fiber showed weight and insulin-related marker improvements—supports metabolic benefit.
- A flexible, low-glycemic index mexican-style diet in overweight and obese subjects with type 2 diabetes improves metabolic parameters during a 6-week treatment period
PubMed ID: 12832297
Low‑GI (higher‑fiber) diet improved A1c in type 2 diabetes patients — metabolic support over weeks.
- Effects of a beverage containing an enzymatically induced-viscosity dietary fiber, with or without fructose, on the postprandial glycemic response to a high glycemic index food in humans
PubMed ID: 12947431
Guar gum reduced early post-meal glucose peaks and incremental glucose AUC in humans, indicating improved postprandial metabolic handling.
- Effect of soluble fiber intake in lipid and glucose levels in healthy subjects: a randomized clinical trial
PubMed ID: 15163472
Soluble fiber lowered LDL and fasting glucose (~12%), supporting metabolic health.
- Supplementation of wheat fibre can improve risk profile in patients with dysmetabolic cardiovascular syndrome
PubMed ID: 15187818
Wheat fiber improved fasting and 2-h glucose and lipids, indicating metabolic support.
- Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial
PubMed ID: 14744846
High-fibre ad libitum diet produced weight and body-fat loss, reflecting improved metabolic energy balance.
- Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women
PubMed ID: 15616799
High-carbohydrate/high-fibre arm showed metabolic effects in insulin-resistant women (moderate support).
- Dietary fiber intake and risk factors for cardiovascular disease in French adults
PubMed ID: 16332650
Cross-sectional associations between higher fiber intake and lower BMI, BP and metabolic risk markers support metabolic benefit (observational).
- Effects of agar (kanten) diet on obese patients with impaired glucose tolerance and type 2 diabetes
PubMed ID: 15642074
Agar led to weight/BMI reductions in obese/IGT or T2DM patients (metabolic improvements).
- Effects of flax fiber on laxation and glycemic response in healthy volunteers
PubMed ID: 16379563
Flax fiber modestly reduced peak glucose and glucose AUC, supporting metabolic (glycemic) benefits.
- Experiences with three different fiber supplements in weight reduction
PubMed ID: 15614200
Viscous fibers accelerated weight loss on hypocaloric diet, indicating metabolic/energy-balance effects.
- Effects of breakfast meal composition on second meal metabolic responses in adults with Type 2 diabetes mellitus
PubMed ID: 16670695
Psyllium-containing breakfast reduced postprandial glucose and insulin in T2D — acute metabolic benefit.
- Effect of a viscous fiber bar on postprandial glycemia in subjects with type 2 diabetes
PubMed ID: 17031010
Viscous fiber markedly reduced postprandial glucose and insulin AUC in type 2 diabetes patients.
- Effectiveness of a lifestyle intervention on metabolic syndrome. A randomized controlled trial
PubMed ID: 17922167
One-year lifestyle intervention (increased fiber) substantially reduced metabolic syndrome, obesity and incident diabetes.
- The benefits of early intervention in obese diabetic patients with FBCx: a new dietary fibre
PubMed ID: 17013969
FBCx maintained weight and raised adiponectin in obese diabetics—metabolic markers suggest support for metabolic health.
- Improvement of insulin resistance after diet with a whole-grain based dietary product: results of a randomized, controlled cross-over study in obese subjects with elevated fasting blood glucose
PubMed ID: 17562226
Whole‑grain, reduced‑starch product improved fasting insulin and HOMA‑IR beyond weight loss—direct metabolic benefit from a fiber‑rich product.
- Hydroxypropylmethylcellulose and methylcellulose consumption reduce postprandial insulinemia in overweight and obese men and women
PubMed ID: 18203894
Viscous cellulose fibers reduced insulin IAUC and peak insulin—meaningful metabolic support (insulin dynamics).
- Diet or exercise: what is more effective in preventing or reducing metabolic alterations?
PubMed ID: 18772269
Observational/lifestyle data show inverse association between fiber and fasting glucose (small effect)—supports metabolic benefit.
- Beneficial effects of a diabetes specific formula on insulin sensitivity and free fatty acid in patients with type 2 diabetes mellitus
PubMed ID: 18701020
High‑fiber diabetes formula meaningfully lowered postprandial glucose/insulin and improved insulin sensitivity (HOMA‑IS) over the short feeding period.
- The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome
PubMed ID: 18175740
Whole‑grain intake led to greater abdominal fat loss and lower CRP during weight loss — indicates favorable metabolic effects associated with higher‑fiber grain intake.
- A randomized behavioural trial targeting glycaemic index improves dietary, weight and metabolic outcomes in patients with type 2 diabetes
PubMed ID: 19161649
Behavioral increase in fiber reduced fasting and postprandial glucose and BMI — direct metabolic improvements.
- Reduction in risk factors for type 2 diabetes mellitus in response to a low-sugar, high-fiber dietary intervention in overweight Latino adolescents
PubMed ID: 19349560
Increased fiber intake in adolescents reduced insulin area-under-curve and visceral adipose tissue — metabolic benefit.
- A low-fat vegan diet elicits greater macronutrient changes, but is comparable in adherence and acceptability, compared with a more conventional diabetes diet among individuals with type 2 diabetes
PubMed ID: 19167953
Low‑fat, high‑fiber vegan diet produced large improvements in HbA1c and weight—direct metabolic benefits.
- Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk
PubMed ID: 19289389
Increased fiber intake associated with lower weight, BP and improved fasting glucose/total cholesterol in older adults.
- Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors: a 12-month randomized controlled weight loss trial
PubMed ID: 20938438
Lupin-enriched high-protein/high-fiber foods improved fasting insulin and HOMA — supports metabolic improvements.
- NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
PubMed ID: 21164548
NUTRIOSE RCT improved insulin resistance, glycemic markers and lipids — strong support for metabolic benefits.
- Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial
PubMed ID: 20413122
Psyllium reduced triglycerides and insulin modestly, indicating beneficial metabolic effects.
- [Effect of an original enteral feeding protocol on clinical outcome indicators in patients with acute cerebral damage of vascular and traumatic genesis]
PubMed ID: 20919542
Enteral hypercalorie + fiber formula improved energy and nitrogen balance in ICU patients—metabolic relevance in clinical context.
- Comparison of high protein and high fiber weight-loss diets in women with risk factors for the metabolic syndrome: a randomized trial
PubMed ID: 21524314
High‑fiber diet arm improved metabolic markers and increased fiber intake substantially—supports metabolic health.
- Randomized controlled trial to improve adiposity, inflammation, and insulin resistance in obese African-American and Latino youth
PubMed ID: 21293446
16‑week intervention increasing fiber (and reducing sugar) improved insulin sensitivity, reduced hepatic fat and lowered inflammatory markers—strong metabolic support.
- Randomized, controlled nutrition education trial promotes a Mediterranean diet and improves anthropometric, dietary, and metabolic parameters in adults
PubMed ID: 21736003
Nutrition education (Mediterranean pattern) raised fibre intake and produced weight loss and a 32% fasting insulin reduction—supports metabolic benefits associated with fibre‑rich diets.
- Effects of supplemented isoenergetic diets differing in cereal fiber and protein content on insulin sensitivity in overweight humans
PubMed ID: 21633074
Isoenergetic diet higher in cereal fiber improved insulin sensitivity ~25% vs high-protein at 6 weeks — strong metabolic support (attenuated by 18 wk).
- Effect of legumes as part of a low glycemic index diet on glycemic control and cardiovascular risk factors in type 2 diabetes mellitus: a randomized controlled trial
PubMed ID: 23089999
Legume intervention improved glycemic control and reduced CHD risk factors, indicating metabolic benefits beyond fiber alone.
- [Importance of nutritional counseling and dietary fiber content on glycemic control in type 2 diabetic patients under intensive educational intervention]
PubMed ID: 22584564
Intensive dietary counseling that raised fiber intake produced markedly better short-term glycemic control in type 2 diabetes—strong indirect evidence of metabolic benefit.
- Dietary associations with prediabetic states--the DR's EXTRA Study (ISRCTN45977199)
PubMed ID: 22415336
Large observational study found higher dietary/cereal fiber linked to lower odds of impaired glucose tolerance (supports metabolic regulation).
- Weight-loss diets modify glucose-dependent insulinotropic polypeptide receptor rs2287019 genotype effects on changes in body weight, fasting glucose, and insulin resistance: the Preventing Overweight Using Novel Dietary Strategies trial
PubMed ID: 22237064
High‑fiber (low‑fat) weight‑loss diet produced modest improvements in fasting glucose, insulin and HOMA‑IR in genotype‑specific subgroups.
- Improvement effect of resistant maltodextrin in humans with metabolic syndrome by continuous administration
PubMed ID: 23419401
Randomized trial: resistant maltodextrin 9 g/day for 12 weeks reduced visceral fat, fasting glucose and triglycerides in metabolic‑syndrome subjects—direct metabolic benefits.
- Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial
PubMed ID: 24332524
Oligofructose-enriched inulin improved fasting glucose and HbA1c in T2D — direct metabolic benefits.
- Low glycaemic index diets improve glucose tolerance and body weight in women with previous history of gestational diabetes: a six months randomized trial
PubMed ID: 23705645
Low‑GI advice that modestly increased fiber improved weight and 2‑hour postload glucose—metabolic support plausible.
- Improvement of the metabolic syndrome profile by soluble fibre - guar gum - in patients with type 2 diabetes: a randomised clinical trial
PubMed ID: 23551992
Guar gum RCT in T2D reduced HbA1c and waist circumference — direct human evidence of metabolic support from a soluble fibre.
- A CHO/fibre diet reduces and a MUFA diet increases postprandial lipaemia in type 2 diabetes: no supplementary effects of low-volume physical training
PubMed ID: 24132660
Carbohydrate+fiber diet reduced postprandial atherogenic lipoproteins in T2D — indicates metabolic improvements tied to higher fiber intake.
- Infancy-onset dietary counseling of low-saturated-fat diet improves insulin sensitivity in healthy adolescents 15-20 years of age: the Special Turku Coronary Risk Factor Intervention Project (STRIP) study
PubMed ID: 23801725
Long-term childhood dietary counseling including more fiber led to modest improvements in insulin sensitivity, supporting metabolic benefit.
- Improvement of fasting plasma glucose level after ingesting moderate amount of dietary fiber in Japanese men with mild hyperglycemia and visceral fat obesity
PubMed ID: 23725526
Daily modest fiber (7.5 g) lowered fasting glucose and modestly reduced weight/BMI in people with mild hyperglycemia/visceral obesity.
- Changes in visceral adiposity and serum cholesterol with a novel viscous polysaccharide in Japanese adults with abdominal obesity
PubMed ID: 23512917
PGX reduced glucose AUC at one time point and lowered abdominal adiposity, suggesting metabolic benefits.
- Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
PubMed ID: 25500202
Reduced energy intake and prevention of weight gain, plus reduced intra‑abdominal/liver fat over 24 weeks — direct metabolic benefits.
- Regular breakfast consumption and type 2 diabetes risk markers in 9- to 10-year-old children in the child heart and health study in England (CHASE): a cross-sectional analysis
PubMed ID: 25181492
High-fiber cereal breakfast associated with lower insulin resistance in children (observational association to metabolic health).
- Taking a low glycemic index multi-nutrient supplement as breakfast improves glycemic control in patients with type 2 diabetes mellitus: a randomized controlled trial
PubMed ID: 25514391
Higher‑fiber, low‑GI breakfast replacement improved HbA1c and fasting glycemia over 12 weeks in T2D, supporting metabolic control.
- Intensive low-glycaemic-load dietary intervention for the management of glycaemia and serum lipids among women with gestational diabetes: a randomized control trial
PubMed ID: 25222105
Low‑GL/higher‑fiber diet produced significant improvements in fasting and postprandial glucose and some lipids in gestational diabetes.
- The impact of soluble dietary fibre on gastric emptying, postprandial blood glucose and insulin in patients with type 2 diabetes
PubMed ID: 24901089
Oat β‑glucan (7.5 g) delayed gastric emptying and significantly lowered postprandial glucose and insulin in T2D — strong metabolic support.
- Effect of two dietary fibers on satiety and glycemic parameters: a randomized, double-blind, placebo-controlled, exploratory study
PubMed ID: 24886409
Oligofructose+pectin gave small reductions in postprandial glucose/insulin and improved insulin sensitivity indices over 3 weeks.
- Resistant starch type 4-enriched diet lowered blood cholesterols and improved body composition in a double blind controlled cross-over intervention
PubMed ID: 24478107
RS4 replacement reduced total/non‑HDL cholesterol and improved body composition — metabolic benefits.
- Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity
PubMed ID: 24997634
Dietary changes raising fiber were accompanied by improved glucose and triglyceride profiles (metabolic benefits).
- A whole-grain cereal-based diet lowers postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome
PubMed ID: 24598599
Whole‑grain intervention markedly lowered postprandial insulin and triglycerides—direct metabolic benefit.
- Diet, insulin secretion and insulin sensitivity--the Dose-Responses to Exercise Training (DR's EXTRA) Study (ISRCTN45977199)
PubMed ID: 25230681
Large observational study: higher dietary fiber/whole‑grain intake associated with better insulin sensitivity (associative evidence).
- Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study
PubMed ID: 24549027
Biomarker of higher whole‑grain/rye (higher fibre) intake correlated with better insulin sensitivity and disposition index in metabolic‑syndrome participants.
- Influence of dietary fat and carbohydrates proportions on plasma lipids, glucose control and low-grade inflammation in patients with type 2 diabetes-The TOSCA.IT Study
PubMed ID: 26303195
Higher fiber intake in people with T2D associated with better glycemic control and lipids, indicating metabolic support.
- Single-component versus multicomponent dietary goals for the metabolic syndrome: a randomized trial
PubMed ID: 25686165
Fiber‑targeted diet achieved modest weight loss and improved HOMA‑IR comparable to an AHA multicomponent diet (metabolic support).
- Effects of total fibre or resistant starch-rich diets within lifestyle intervention in obese prediabetic adults
PubMed ID: 25588971
High‑fiber advice improved 2‑h OGTT glycaemia in overweight/prediabetic adults—metabolic support.
- Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial
PubMed ID: 27810310
Prebiotic+probiotic reduced body fat and energy intake, indicating metabolic influence.
- Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial
PubMed ID: 26811130
Pea fiber reduced body fat and improved glucose AUC (metabolic outcomes) over 12 weeks.
- Short- and Long-Term Effects of Wholegrain Oat Intake on Weight Management and Glucolipid Metabolism in Overweight Type-2 Diabetics: A Randomized Control Trial
PubMed ID: 27618090
Whole‑grain oats improved postprandial glucose and HbA1c at 1 year in overweight T2D participants.
- Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial)
PubMed ID: 27733151
Psyllium markedly reduced fasting glucose and HbA1c and produced weight loss in T2D (direct metabolic improvements).
- Effects of oat bran and nutrition counseling on the lipid and glucose profile and anthropometric parameters of hypercholesterolemia patients
PubMed ID: 27019267
Oat bran improved insulin‑resistance indices (HOMA‑IR, QUICKI) beyond counseling—direct metabolic support evidence.
- Insulin resistance, postprandial GLP-1 and adaptive immunity are the main predictors of NAFLD in a homogeneous population at high cardiovascular risk
PubMed ID: 27134062
Observational association: higher dietary fiber linked to less liver fat in people at cardiometabolic risk, implying metabolic support.
- Substituting whole grains for refined grains in a 6-wk randomized trial favorably affects energy-balance metrics in healthy men and postmenopausal women
PubMed ID: 28179223
Whole‑grain substitution modestly increased RMR and stool energy losses, implying an effect on energy balance/metabolism.
- Co-administration of a konjac-based fibre blend and American ginseng (Panax quinquefolius L.) on glycaemic control and serum lipids in type 2 diabetes: a randomized controlled, cross-over clinical trial
PubMed ID: 28687934
Konjac glucomannan lowered HbA1c and improved lipid markers in people with type 2 diabetes.
- Effect on Insulin, Glucose and Lipids in Overweight/Obese Australian Adults of 12 Months Consumption of Two Different Fibre Supplements in a Randomised Trial
PubMed ID: 28146065
PGX and psyllium improved fasting insulin and HOMA‑IR, indicating metabolic benefits.
- Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial
PubMed ID: 29162875
A fibre‑rich diet (especially with exercise) substantially reduced liver fat and improved insulin sensitivity in people with prediabetes and fatty liver.
- Increased fibre and reduced trans fatty acid intake are primary predictors of metabolic improvement in overweight polycystic ovary syndrome-Substudy of randomized trial between diet, exercise and diet plus exercise for weight control
PubMed ID: 28727165
In overweight women with PCOS, increased fiber intake strongly predicted greater weight loss and metabolic improvements.
- Effect of Fibre Supplementation on Body Weight and Composition, Frequency of Eating and Dietary Choice in Overweight Individuals
PubMed ID: 28212353
Viscous fiber (PGX) produced modest weight and waist reductions that favor metabolic health.
- Short-Term Supplementation of a Moderate Carbohydrate Diet with Psyllium Reduces Fasting Plasma Insulin and Tumor Necrosis Factor-α in Patients with Type 2 Diabetes Mellitus
PubMed ID: 28956658
Psyllium supplementation lowered fasting insulin and TNF-α and improved insulin sensitivity in T2D patients (metabolic benefit).
- Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial
PubMed ID: 28089709
Controlled feeding produced reproducible urinary metabolite changes that tracked healthier, higher-fiber diets (metabolic signature).
- [Effect of quinua (Chenopodium quinoa)consumption as a coadjuvant in nutritional intervention in prediabetic subjects]
PubMed ID: 29130716
Processed quinoa reduced HbA1c and BMI in prediabetics over 28 days, suggesting metabolic benefits.
- Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention
PubMed ID: 28883543
High‑fiber whole‑food diet led to greater fat and waist loss in certain microbiome profiles, indicating metabolic benefit.
- Effects of supplemented isoenergetic diets varying in cereal fiber and protein content on the bile acid metabolic signature and relation to insulin resistance
PubMed ID: 29549243
Controlled diet trial: cereal fiber improved insulin sensitivity in overweight participants
- Weight loss and metabolic health effects from energy-restricted Mediterranean and Central-European diets in postmenopausal women: A randomized controlled trial
PubMed ID: 30042488
Higher fiber increase correlated with greater visceral fat loss among adherent participants—metabolic body‑fat effect.
- Impact of Diets Rich in Whole Grains and Fruits and Vegetables on Cardiovascular Risk Factors in Overweight and Obese Women: A Randomized Clinical Feeding Trial
PubMed ID: 29702040
Whole-grain weight-loss diet improved weight, waist, lipids and glucose—broad metabolic improvements.
- A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects
PubMed ID: 30541093
Prevented large increase in intrahepatic triglycerides and preserved microbiota during 12 weeks—beneficial metabolic effect.
- A Plant-Based High-Carbohydrate, Low-Fat Diet in Overweight Individuals in a 16-Week Randomized Clinical Trial: The Role of Carbohydrates
PubMed ID: 30223451
High-fiber, plant-based diet produced marked reductions in weight, visceral fat and HOMA-IR over 16 weeks — strong metabolic support.
- Success in Achieving the Targets of the 20-Year Infancy-Onset Dietary Intervention: Association With Insulin Sensitivity and Serum Lipids
PubMed ID: 30072407
Dietary counseling including higher fiber linked to better insulin sensitivity and lipids through youth, supporting metabolic health.
- A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
PubMed ID: 30425247
Dietary cereal‑fiber changes caused small weight loss and hormonal shifts (PYY), relevant to metabolism.
- A proof-of-concept study to evaluate the efficacy and safety of BTI320 on post-prandial hyperglycaemia in Chinese subjects with pre-diabetes
PubMed ID: 30170579
Galactomannan reduced postprandial glucose excursions and produced modest weight loss—direct metabolic benefits.
- A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome markers
PubMed ID: 30382274
Grape pomace supplementation lowered fasting insulin in at‑risk subjects—an index of metabolic improvement.
- Effect of an individualised high-protein, energy-restricted diet on anthropometric and cardio-metabolic parameters in overweight and obese Malaysian adults: a 6-month randomised controlled study
PubMed ID: 30761964
Diet higher in protein and fibre produced significant improvements in weight, insulin and inflammation—clear metabolic support.
- Okara Improved Blood Glucose Level in Vietnamese with Type 2 Diabetes Mellitus
PubMed ID: 30814413
Okara fiber supplementation for 2 weeks modestly lowered fasting glucose and fructosamine in people with type 2 diabetes.
- Pretreatment Prevotella-to-Bacteroides ratio and markers of glucose metabolism as prognostic markers for dietary weight loss maintenance
PubMed ID: 31285554
Strong RCT evidence that habitual fiber intake interacts with gut microbiome and glucose metabolism to influence clinically meaningful weight regain—direct metabolic support link.
- Impact of oat processing on glycaemic and insulinaemic responses in healthy humans: a randomised clinical trial
PubMed ID: 31068229
Less-processed oats produced lower glucose and insulin responses versus refined control — meaningful metabolic effect.
- Weight loss at your fingertips: personalized nutrition with fasting glucose and insulin using a novel statistical approach
PubMed ID: 30967642
High-fiber, whole-grain diet (NND) influenced weight loss responses related to baseline metabolic biomarkers.
- Obesity Does Not Modulate the Glycometabolic Benefit of Insoluble Cereal Fibre in Subjects with Prediabetes-A Stratified Post Hoc Analysis of the Optimal Fibre Trial (OptiFiT)
PubMed ID: 31717901
Insoluble cereal fibre produced modest improvements in 2-hr glucose and reduced leukocyte count in obese participants, indicating metabolic/inflammatory support.
- Pretreatment Fasting Glucose and Insulin as Determinants of Weight Loss on Diets Varying in Macronutrients and Dietary Fibers-The POUNDS LOST Study
PubMed ID: 30861997
Higher dietary fiber intake associated with greater long-term weight loss in energy-restricted diets, especially in prediabetes/low-insulin subgroups—strong metabolic relevance.
- Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults: A Randomized Clinical Trial
PubMed ID: 33252690
High‑fiber vegan diet increased insulin sensitivity and post-meal energy expenditure—direct metabolic support.
- Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort
PubMed ID: 32369545
Observational links between higher fiber intake and lower diabetes/CVD risk imply metabolic benefits at population level.
- Visceral Fat-Reducing Effect and Safety of Continuous Consumption of Beverage Containing Resistant Maltodextrin: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial
PubMed ID: 33132344
Resistant maltodextrin RCT reduced visceral fat modestly, suggesting metabolic/adiposity-relevant effects.
- Carbohydrate quality changes and concurrent changes in cardiovascular risk factors: a longitudinal analysis in the PREDIMED-Plus randomized trial
PubMed ID: 31868210
Higher carbohydrate quality (more fiber) associated with improved glycemic and metabolic markers in a large trial.
- Impact of the Dietary Approaches to Stop Hypertension (DASH) diet on glycaemic control and consumption of processed and ultraprocessed foods in pregnant women with pre-gestational diabetes mellitus: a randomised clinical trial
PubMed ID: 33256869
DASH (higher‑fiber) diet increased proportion achieving glycaemic control in pregnant women with pre‑gestational diabetes — metabolic support evidence.
- Human clinical trial to assess the effect of consumption of multigrain Indian bread on glycemic regulation in type 2 diabetic participants
PubMed ID: 33006193
Multigrain/millet substitution improved insulin and HbA1c in T2DM—direct metabolic support.
- Replacing Animal-Based Proteins with Plant-Based Proteins Changes the Composition of a Whole Nordic Diet-A Randomised Clinical Trial in Healthy Finnish Adults
PubMed ID: 32231103
Switching to plant proteins increased fiber and reduced LDL/total cholesterol, reflecting favorable metabolic/lipid effects.
- Dietary Fibres and the Management of Obesity and Metabolic Syndrome: The RESOLVE Study
PubMed ID: 32977595
During the RESOLVE program the increase in fiber intake strongly predicted improved body composition and glycaemic markers — direct metabolic support evidence.
- Effect of a functional fibre supplement on glycemic control when added to a year-long medically supervised weight management program in adults with type 2 diabetes
PubMed ID: 32642971
PGX produced modest sustained reductions in HbA1c and weight across 52 weeks (metabolic improvements).
- Ingestion of Helianthus tuberosus at Breakfast Rather Than at Dinner Is More Effective for Suppressing Glucose Levels and Improving the Intestinal Microbiota in Older Adults
PubMed ID: 33022987
Inulin (Helianthus tuberosus) lowered 24‑h/postprandial glucose and shifted microbiota after 1 week (glycemic/metabolic benefit).
- Development and empirical evaluation of a dietary intervention programme for individuals with prediabetes based on the health action process approach: A randomised controlled trial
PubMed ID: 41421300
HAPA‑based program increased fibre‑rich intakes and improved BMI and glucose in prediabetes—direct metabolic benefits.
- Comparison of Low-Gluten Diets Rich in Oats or Rice-A 6-Week Randomized Clinical Trial With Metabolically Challenged Volunteers
PubMed ID: 40331457
Oat diet lowered LDL and modestly affected waist circumference—metabolic risk markers improved.
- Fibre-Enriched High-Carbohydrate (FEHC) Diet Modulates Inflammation Without Affecting Bone Health in Older Women With Obesity: A Randomised Clinical Trial
PubMed ID: 41026958
High‑fiber diet reduced systemic inflammation in older women with obesity, which can improve metabolic health.
- NUTRIOSE® soluble fibre supplementation as an effective dietary strategy to improve glycaemic response
PubMed ID: 40167751
NUTRIOSE soluble fiber improved 24‑hour glycaemic control and trunk body composition—metabolic improvements.
- Supplementing the standard diet with brown rice bran powder might effectively improve the metabolic syndrome characteristics and antioxidant status: an open label randomized controlled trial
PubMed ID: 39775811
Brown rice bran improved BMI, LDL and fasting glucose in metabolic syndrome—metabolic benefit.
- ApoC-III and ectopic fat accumulation in individuals with type 2 diabetes: an exploratory analysis from the MEDEA randomised controlled study
PubMed ID: 40471240
A multifactorial diet including more fiber modestly lowered postprandial ApoC‑III and changes correlated with reduced ectopic fat and better beta‑cell function.
- Effects of Aerobic-Resistance Training and Nutritional Intervention on Adiponectin, Interleukin-6, and hs-CRP Concentrations in Men with Abdominal Obesity-A Randomized Controlled Trial
PubMed ID: 41096768
Higher‑fiber, low‑GI diet plus exercise improved adiponectin and reduced IL‑6/hs‑CRP, markers of improved metabolic state.
- Impact of a high dietary fiber cereal meal intervention on the progression of liver fibrosis in T2DM with MASLD
PubMed ID: 40958906
24 g/day fiber cereal in T2DM improved HbA1c and liver fibrosis markers, indicating metabolic support.
- Impact of a 12-week personalized dietary intervention on vascular function and cardiovascular risk factors
PubMed ID: 40013435
Phenotype‑guided diets (with fiber changes) improved insulin sensitivity and metabolic risk factors.
- Gut microbiome predicts personalized responses to dietary fiber in prediabetes: a randomized, open-label trial
PubMed ID: 41390484
Large fiber‑supplement RCT produced cluster‑specific glycemic improvements, indicating metabolic effects mediated by fiber.
- A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial
PubMed ID: 39843443
Legume‑rich high‑fibre diet improved HbA1c, lipids and body composition—clear metabolic support.
- Impact of diet intervention on visceral adipose tissue and hepatic fat in patients with obesity or type 2 diabetes: a randomized trial
PubMed ID: 39271914
Dietary intervention including high‑fiber staple reduced visceral adiposity, hepatic fat, and body weight — beneficial metabolic effects.
- Effects of a diverse prebiotic fibre supplement on HbA1c, insulin sensitivity and inflammatory biomarkers in pre-diabetes: a pilot placebo-controlled randomised clinical trial
PubMed ID: 38654680
24‑week prebiotic fiber supplement in pre‑diabetes improved insulin sensitivity and reduced CRP vs placebo — direct metabolic benefit.
- Fasting and postprandial plasma metabolite responses to a 12-wk dietary intervention in tissue-specific insulin resistance: a secondary analysis of the PERSonalized glucose Optimization through Nutritional intervention (PERSON) randomized trial
PubMed ID: 38851634
High‑fiber dietary pattern produced favorable postprandial lipid changes, indicating improved metabolic handling of lipids.
- A Randomized Trial of the Efficacy of Three Weight Loss Diet Interventions in Overweight/Obese with Polycystic Ovary Syndrome
PubMed ID: 38988067
Weight‑loss diets with high dietary fiber produced greater visceral fat reduction and improved oxidative stress markers — metabolic benefits within a diet program.
- Long-term clinical efficacy of dietary fiber supplementation in middle-aged and elderly prediabetic patients
PubMed ID: 39406174
Mixed fiber supplementation reduced fasting and 2‑hour glucose and lowered diabetes incidence, improving metabolic outcomes.
- Administration of a diabetes-specific formula can improve postprandial glycemic control and delay insulin use in gestational diabetes mellitus: A randomized controlled trial from two centers
PubMed ID: 39536397
Diabetes‑specific formula with fiber in GDM reduced postprandial glucose and delayed/shortened insulin use, reflecting metabolic support.
- Effect of Intake of Bifidobacteria and Dietary Fiber on Resting Energy Expenditure: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparison Study
PubMed ID: 39064788
Synbiotic (B. lactis + inulin) RCT increased resting energy expenditure, a direct metabolic effect.
- Longitudinal associations of dietary fiber and its source with 48-week weight loss maintenance, cardiometabolic risk factors and glycemic status under metformin or acarbose treatment: a secondary analysis of the March randomized trial
PubMed ID: 39358341
Large cohort analysis: higher total/whole‑grain/legume fiber associated with better postprandial glucose control and improved β‑cell function.
- Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota
PubMed ID: 38409604
8‑week resistant‑starch RCT produced clinically meaningful weight/fat loss, improved insulin sensitivity and favorable metabolic/inflammatory changes.
- The ALINFA Intervention Improves Diet Quality and Nutritional Status in Children 6 to 12 Years Old
PubMed ID: 37242258
ALINFA program increased fiber and improved BMI z‑score/leptin in children—indirect metabolic benefits.
- Effect of nutritional promotion intervention on dietary adherence among type II diabetes patients in North Shoa Zone Amhara Region: quasi-experimental study
PubMed ID: 37254151
Six‑month nutrition program in T2D increased high‑fiber food adherence and improved fasting blood glucose—supports metabolic control.
- HIGH-FIBER DIET PROMOTES METABOLIC, HORMONAL, AND SATIETY EFFECTS IN OBESE WOMEN ON A SHORT-TERM CALORIC RESTRICTION
PubMed ID: 37556741
High‑fiber calorie‑restricted diet improved fasting glucose, insulin and HOMA‑IR in obese women.
- Effects of a novel rice-based diabetes-specific formula on postprandial glucose and gastrointestinal hormones: a double-blinded multi-arm randomized crossover trial
PubMed ID: 37293492
A fiber-containing diabetes-specific enteral formula produced lower postprandial glucose and insulin AUCs—direct metabolic benefit.
- Effects of Synbiotic Supplementation on Metabolic Syndrome Traits and Gut Microbial Profile among Overweight and Obese Hong Kong Chinese Individuals: A Randomized Trial
PubMed ID: 37836532
Fiber‑rich diet plus synbiotic achieved larger weight loss and better glycemic markers vs controls, indicating metabolic support.
- Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial
PubMed ID: 36599304
Dietary interventions with higher fiber improved insulin sensitivity, glucose control, TG and inflammatory markers in a sizable trial.
- Dietary Supplementation with Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), Reduces Visceral Fat and Hyperlipidemia in Inhabitants of a Rural Community in Mexico
PubMed ID: 36004709
Mushroom (fiber) intervention reduced visceral fat and improved lipids/glucose in a small trial—suggests metabolic effects.
- Tapioca Resistant Maltodextrin as a Carbohydrate Source of Oral Nutrition Supplement (ONS) on Metabolic Indicators: A Clinical Trial
PubMed ID: 35267892
Tapioca resistant maltodextrin reduced postprandial insulin and improved HbA1c over 12 weeks—direct metabolic support.
- Effect of sodium alginate supplementation on weight management and reproductive hormones in polycystic females
PubMed ID: 36047511
Sodium alginate trial showed weight‑related benefits in PCOS, suggesting metabolic support.
- Nutritional Impact and Eating Pattern Changes in Schizophrenic Spectrum Disorders after Health Education Program on Symbiotic Dietary Modulation Offered by Specialised Psychiatric Nursing-Two-Arm Randomised Clinical Trial
PubMed ID: 36558548
Symbiotic‑focused dietary counselling improved nutrient intake and anthropometrics in schizophrenia patients.
- Impact of high prebiotic and probiotic dietary education in the SARS-CoV-2 era: improved cardio-metabolic profile in schizophrenia spectrum disorders
PubMed ID: 36510155
High prebiotic/probiotic dietary education produced weight, waist and metabolic syndrome improvements (multimodal intervention).
- Effectiveness of Textured Soybean Protein on Blood Biochemistry in Vietnamese Type 2 Diabetes Mellitus Patients
PubMed ID: 35228493
Textured soybean protein (increasing fiber) modestly lowered fructosamine and lipids over 4 weeks—metabolic signals though not fiber‑only.
- Increasing the diversity of dietary fibers in a daily-consumed bread modifies gut microbiota and metabolic profile in subjects at cardiometabolic risk
PubMed ID: 35311446
Multi‑fiber bread improved fasting insulin/HOMA and lowered LDL—direct metabolic improvements in a cardiometabolic‑risk cohort.
- Probiotics Plus Dietary Fiber Supplements Attenuate Olanzapine-Induced Weight Gain in Drug-Naïve First-Episode Schizophrenia Patients: Two Randomized Clinical Trials
PubMed ID: 35569003
Probiotics plus dietary fiber attenuated olanzapine‑associated weight gain and improved fasting insulin/HOMA‑IR—metabolic support in a drug‑exposed population.
- Longitudinal association of dietary carbohydrate quality with visceral fat deposition and other adiposity indicators
PubMed ID: 36084360
Higher carbohydrate quality driven by fiber linked to reductions in visceral and total fat (large study).
- Changes in Food and Nutrient Intake and Diet Quality on a Low-Fat Vegan Diet Are Associated with Changes in Body Weight, Body Composition, and Insulin Sensitivity in Overweight Adults: A Randomized Clinical Trial
PubMed ID: 35452873
Low‑fat vegan diet increased fiber and led to weight loss and modest insulin improvements.
- An Isoenergetic Multifactorial Diet Reduces Pancreatic Fat and Increases Postprandial Insulin Response in Patients With Type 2 Diabetes: A Randomized Controlled Trial
PubMed ID: 35862001
Multifactorial diet including more fiber reduced pancreatic fat and changed early postprandial insulin (metabolic benefit, fiber among components).
- Chronic consumption of probiotics, oats, and apples has differential effects on postprandial bile acid profile and cardiometabolic disease risk markers compared with an isocaloric control (cornflakes): a randomized trial
PubMed ID: 36811563
Oats/apples lowered post‑meal insulin/C‑peptide responses acutely — favorable metabolic effects from fiber‑containing foods.
- Diverging metabolic effects of 2 energy-restricted diets differing in nutrient quality: a 12-week randomized controlled trial in subjects with abdominal obesity
PubMed ID: 35102369
Higher‑quality (higher‑fiber) energy restriction led to greater weight loss and better triglyceride/total cholesterol responses.
- The effects of probiotics plus dietary fiber on antipsychotic-induced weight gain: a randomized clinical trial
PubMed ID: 35508529
Probiotics+fiber prevented antipsychotic‑associated metabolic deterioration (weight, insulin), supportive of metabolic health.
- Flaxseed Mucilage (IQP-LU-104) Reduces Body Weight in Overweight and Moderately Obese Individuals in a 12-week, Three-Arm, Double-Blind, Randomized, and Placebo-Controlled Clinical Study
PubMed ID: 35130547
Flaxseed mucilage RCT produced marked weight and fat‑mass loss — strong metabolic relevance.
- Consuming a Protein and Fiber-Based Supplement Preload Promotes Weight Loss and Alters Metabolic Markers in Overweight Adults in a 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 35212740
Protein+fiber preload produced greater weight loss and improved adiponectin and lipids — clear metabolic benefits in RCT.
- Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial
PubMed ID: 34226572
In mouse models rhamnan sulphate improved blood lipids; human data also showed trends in glucose — indicates metabolic support beyond transit.
- Efficacy of green jackfruit flour as a medical nutrition therapy replacing rice or wheat in patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study
PubMed ID: 34127645
Replacing staple foods with a fiber‑rich jackfruit flour improved HbA1c and fasting/postprandial glucose — direct metabolic benefit.
- Dietary influence on adiponectin in patients with type 2 diabetes
PubMed ID: 33797089
Fiber‑rich/low‑GI carbohydrate diet increased postprandial adiponectin and related to liver fat measures — supports metabolic benefits.
- The effect of oat bran consumption on gestational diabetes: a randomized controlled clinical trial
PubMed ID: 33849494
Oat bran in GDM significantly lowered fasting and 2‑hr postprandial glucose → strong metabolic support (glycemia).
- Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men
PubMed ID: 33629506
20 g/day inulin/resistant maltodextrin plus caloric restriction altered microbiota/SCFAs and gave greater metabolic benefit in women.
- A hypocaloric diet rich in high fiber rye foods causes greater reduction in body weight and body fat than a diet rich in refined wheat: A parallel randomized controlled trial in adults with overweight and obesity (the RyeWeight study)
PubMed ID: 34620312
High‑fiber rye in calorie restriction led to greater weight and body‑fat loss and lower CRP, supporting metabolic improvements.
- Interventional effect of dietary fiber on blood glucose and pregnancy outcomes in patients with gestational diabetes mellitus
PubMed ID: 34402253
Adding ~9.5 g/day fiber in gestational diabetes improved 2‑hour postprandial glucose and reduced postpartum impaired glucose tolerance — direct metabolic benefit.
- Dietary Blueberry and Soluble Fiber Supplementation Reduces Risk of Gestational Diabetes in Women with Obesity in a Randomized Controlled Trial
PubMed ID: 33693835
Soluble fiber + blueberries reduced gestational weight gain and improved glucose screening, indicating metabolic benefit.
- Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial
PubMed ID: 34226737
Low‑fermentable fiber given with oral FMT modestly improved insulin sensitivity at 6 weeks in severe obesity (metabolic effect).
- Policaptil Gel Retard Intake Reduces Postprandial Triglycerides, Ghrelin and Appetite in Obese Children: A Clinical Trial
PubMed ID: 31947628
Premeal fiber lowered postprandial triglycerides in obese children (direct metabolic effect).
- A dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnormalities by modifying faecal microbiota in people with type 2 diabetes
PubMed ID: 30266575
High‑fiber/polyphenol diet lowered HbA1c and LDL and reduced CRP, indicating improved metabolic markers.
- Impact of a low-carbohydrate and high-fiber diet on nonalcoholic fatty liver disease
PubMed ID: 32990607
Low‑carb, high‑fiber program improved weight, visceral fat, glycemia and liver enzymes—fiber likely contributed to metabolic improvements.
- Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
PubMed ID: 35300378
Konjac glucomannan produced weight/fat and HbA1c reductions—strong metabolic effects from a fermentable fiber.
- Diet and sex hormone-binding globulin
PubMed ID: 10634401
Large cross-sectional study: higher fiber intake associated with higher SHBG, a hormone-binding protein linked to metabolic regulation.
- Metabolomic analysis of plasma metabolites that may mediate effects of rye bread on satiety and weight maintenance in postmenopausal women
PubMed ID: 21084654
High‑fiber rye bread changed plasma metabolites that may relate to satiety and weight maintenance (metabolic signalling).
- Effects of a healthy Nordic diet on cardiovascular risk factors in hypercholesterolaemic subjects: a randomized controlled trial (NORDIET)
PubMed ID: 20964740
Nordic (high‑plant/fiber) diet reduced fasting insulin in addition to lipids, indicating metabolic benefits in humans (multi‑component diet).
- Effect of unsaturated fat and protein intake on liver fat in people at risk of unhealthy aging: 1-year results of a randomized controlled trial
PubMed ID: 36804020
A high-fiber-containing diet reduced intrahepatic lipid and improved lipids in adherent participants, consistent with metabolic benefits though multiple diet changes confound attribution.
- Rapid benefits in older age from transition to whole food diet regardless of protein source or fat to carbohydrate ratio: Arandomised control trial
PubMed ID: 39011855
Switch to whole-food diet increased fiber, produced modest weight loss and raised plasma acetate (a metabolic SCFA), supporting metabolic impact of higher fiber intake.
- Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention
PubMed ID: 39864520
Inulin altered plasma and fecal metabolites, and some lipid/metabolite changes correlated with liver-related parameters, indicating metabolic effects of fermentable fiber.
- An Anthocyanin-Rich Mixed-Berry Intervention May Improve Insulin Sensitivity in a Randomized Trial of Overweight and Obese Adults
PubMed ID: 31775396
Mixed‑berry interventions reduced postprandial insulin AUC under controlled diets—metabolic benefit related to fiber+polyphenols.
- Diabetes Therapeutics of Prebiotic Soluble Dietary Fibre and Antioxidant Anthocyanin Supplement in Patients with Type 2 Diabetes: Randomised Placebo-Controlled Clinical Trial
PubMed ID: 40218856
Inulin + rice bran (fiber) + anthocyanins significantly reduced FPG (−11.9%), HbA1c (−6.7%) and LDL‑C in T2DM (DBPC RCT).
- Alternative Foods in Cardio-Healthy Dietary Models That Improve Postprandial Lipemia and Insulinemia in Obese People
PubMed ID: 34209561
FAWGT fiber‑rich diet reduced postprandial TG and insulin responses and improved HOMA‑IR—beneficial metabolic effects.
- Effects of high β-glucan barley on visceral fat obesity in Japanese individuals: A randomized, double-blind study
PubMed ID: 28870472
Replacing rice with high β‑glucan barley modestly reduced visceral fat and body weight in an RCT—metabolic support.
- Efficacy of fibre additions to flatbread flour mixes for reducing post-meal glucose and insulin responses in healthy Indian subjects
PubMed ID: 28260548
Chickpea + guar gum flatbreads significantly lowered postprandial glucose and insulin in a large crossover—metabolic benefit.
- Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics
PubMed ID: 30046942
Barley kernel bread improved next‑meal glucose tolerance and insulin responses; microbiota interactions support metabolic effects.
- Barley-Based Cereals Enhance Metabolic Health and Satiety in Overweight Korean Adults: A Randomized Trial
PubMed ID: 40944189
6‑week barley cereal improved percent body fat, waist circumference and HOMA‑IR in overweight adults—solid metabolic benefit.
- Differential Effects of Red Meat/Refined Grain Diet and Dairy/Chicken/Nuts/Whole Grain Diet on Glucose, Insulin and Triglyceride in a Randomized Crossover Study
PubMed ID: 27809219
Wholegrain/nuts/dairy meal (higher quality fiber) produced much lower postprandial insulin and glucose vs red‑meat/refined pattern—fiber implicated in metabolic responses.
- Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure
PubMed ID: 17151592
β‑glucan foods improved post‑meal insulin responses, indicating metabolic support.
- The consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes
PubMed ID: 19230737
Lowered LDL and improved HOMA‑IR in T2D—direct support for improved metabolic markers.
- Effect of adding oat bran to instant oatmeal on glycaemic response in humans - a study to establish the minimum effective dose of oat β-glucan
PubMed ID: 29480316
Dose‑dependent oat β‑glucan reduced postprandial glucose AUC and peak rise, indicating metabolic support.
- Postprandial Glycemic and Insulinemic Response by a Brewer's Spent Grain Extract-Based Food Supplement in Subjects with Slightly Impaired Glucose Tolerance: A Monocentric, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 36235569
Brewer’s‑spent‑grain extract lowered late postprandial glucose and reduced insulin AUC (~20%) acutely.
- Diets rich in whole grains increase betainized compounds associated with glucose metabolism
PubMed ID: 30256894
Whole‑grain/bran increased betainized metabolites that correlated with improved postprandial glucose/insulin.
- Addition of Orange Pomace to Orange Juice Attenuates the Increases in Peak Glucose and Insulin Concentrations after Sequential Meal Ingestion in Men with Elevated Cardiometabolic Risk
PubMed ID: 27170728
Orange pomace fiber lowered and delayed postprandial glucose and insulin peaks in at‑risk men.
- Orange Pomace Improves Postprandial Glycemic Responses: An Acute, Randomized, Placebo-Controlled, Double-Blind, Crossover Trial in Overweight Men
PubMed ID: 28208806
High‑fiber orange pomace beverage reduced post-meal glucose and insulin AUC, indicating metabolic support.
- Modulation of amino acid metabolic signatures by supplemented isoenergetic diets differing in protein and cereal fiber content
PubMed ID: 25157543
Cereal-fiber increases changed amino-acid signatures and explained ~70% of changes in whole-body insulin resistance—strong metabolic support evidence.
- Effects of whole-grain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome
PubMed ID: 26706023
Whole‑grain intake raised propionate and associated with lower postprandial insulin in responders.
- Effects of high-fiber diets enriched with carbohydrate, protein, or unsaturated fat on circulating short chain fatty acids: results from the OmniHeart randomized trial
PubMed ID: 31927581
High-fiber diets changed circulating SCFAs with correlations to lower insulin and glucose—supports metabolic effects of fiber.
- The Effects of High Fiber Rye, Compared to Refined Wheat, on Gut Microbiota Composition, Plasma Short Chain Fatty Acids, and Implications for Weight Loss and Metabolic Risk Factors (the RyeWeight Study)
PubMed ID: 35458231
Hypocaloric high-fiber rye produced plasma butyrate rises and reduced CRP during weight loss—metabolic/inflammatory improvements.
- Reduction of De Novo Lipogenesis Mediates Beneficial Effects of Isoenergetic Diets on Fatty Liver: Mechanistic Insights from the MEDEA Randomized Clinical Trial
PubMed ID: 35631319
Higher‑fiber/polyphenol/n‑3 PUFA multifactorial diet reduced de novo lipogenesis index and produced larger liver‑fat loss (direct metabolic effect).
- A microbiome-targeting fibre-enriched nutritional formula is well tolerated and improves quality of life and haemoglobin A1c in type 2 diabetes: A double-blind, randomized, placebo-controlled trial
PubMed ID: 36594522
Microbiome‑targeting fiber formula lowered HbA1c and shifted butyrate‑producers—metabolic improvements in type 2 diabetes.
- Impact of Combined Prebiotic Galacto-Oligosaccharides and Bifidobacterium breve-Derived Postbiotic on Gut Microbiota and HbA1c in Prediabetic Adults: A Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 39064648
Soluble‑fiber/prebiotic supplement in prediabetes lowered HbA1c and fasting glucose (improves glycaemic metabolism).
- Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity
PubMed ID: 40669445
Chicory root increased butyrate activity and improved peripheral insulin sensitivity and triglycerides in people with obesity.
- Short-chain fatty acid kinetics and concentrations are higher after inulin supplementation in young and older adults: a randomized trial
PubMed ID: 40274191
Inulin increased SCFA production and plasma butyrate—mechanistic support for metabolic effects.
- [The use of highly purified glucomannan-based fibers in childhood obesity]
PubMed ID: 1324483
Glucomannan plus diet reduced excess weight and triglycerides in children, implying metabolic support.
- The effect of daily fortified yogurt consumption on weight loss in adults with metabolic syndrome: A 10-week randomized controlled trial
PubMed ID: 29724529
Fortified yogurt containing prebiotic fiber improved body composition and HOMA-IR versus plain yogurt; multi-ingredient limits attribution but supports metabolic benefit.
- Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis
PubMed ID: 29777234
Baseline microbiome predicted greater weight/fat loss on higher-fiber diets, indicating fiber can interact with metabolism to affect weight loss.
- Nutritional quality of calorie restricted diets in the CALERIE™ 1 trial
PubMed ID: 35643360
Calorie-restriction trial with increased fiber and improved diet quality plausibly supports metabolic health (weight and nutrient markers).
- Beneficial Effects of a Freeze-Dried Kale Bar on Type 2 Diabetes Patients: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
PubMed ID: 39519473
Kale bars (high‑fiber whole food) improved HbA1c and HOMA‑IR in T2D — direct evidence that a high‑fiber intervention can support metabolic control.
- Co-administration of viscous fiber, Salba-chia and ginseng on glycemic management in type 2 diabetes: a double-blind randomized controlled trial
PubMed ID: 33486572
24-week RCT in T2D: viscous-fiber-containing supplement (plus chia/ginseng) produced modest, significant HbA1c reduction—direct metabolic benefit.
- Single-blind, placebo controlled randomised clinical study of chitosan for body weight reduction
PubMed ID: 26747458
Chitosan over 90 days produced ~3 kg weight loss and modest HbA1c reductions in higher-baseline subgroup, indicating metabolic support.
- The effects of chitosan supplementation on anthropometric indicators of obesity, lipid and glycemic profiles, and appetite-regulated hormones in adolescents with overweight or obesity: a randomized, double-blind clinical trial
PubMed ID: 36064382
Chitosan reduced weight/waist and favorably altered appetite hormones and insulin-related markers in adolescents.
- Improvements in Glycemic, Micronutrient, and Mineral Indices in Arab Adults with Pre-Diabetes Post-Lifestyle Modification Program
PubMed ID: 31731609
Six‑month lifestyle program that raised fiber intake improved glycemic measures in prediabetes—supports metabolic benefits (multi-component).
- Metabolomic profiling of a cholesterol lowering plant-based diet from two randomized controlled feeding trials
PubMed ID: 40263496
RCTs showed reproducible changes in many blood metabolites after a viscous-fiber–containing plant diet, indicating metabolic impact though multi-component.
- Impact of some isoenergetic snacks on satiety and next meal intake in healthy adults
PubMed ID: 19743984
Acute reduction in next‑meal energy intake after a fibre‑enriched yogurt suggests short‑term metabolic/energy‑balance effects that could support metabolic goals.
- The inclusion of a partial meal replacement with or without inulin to a calorie restricted diet contributes to reach recommended intakes of micronutrients and decrease plasma triglycerides: a randomized clinical trial in obese Mexican women
PubMed ID: 22703579
Inulin (fiber) added to low‑calorie diets reduced triglycerides and aided weight loss in obese women → moderate metabolic benefit.
Gut health (204)
- Impact of fibre supplementation on microbiome and resilience in healthy participants: A randomized, placebo-controlled clinical trial
PubMed ID: 38499450
Acacia gum + carrot fiber altered gut microbiome β‑ and α‑diversity (clear compositional shifts) though SCFA unchanged.
- Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial
PubMed ID: 30420171
Higher Akkermansia muciniphila correlated with higher dietary fiber intake and lower fat mass—associative evidence that fiber supports certain beneficial taxa.
- Resistant Maltodextrin Consumption in a Double-Blind, Randomized, Crossover Clinical Trial Induces Specific Changes in Potentially Beneficial Gut Bacteria
PubMed ID: 35683992
Resistant maltodextrin (soluble fiber) directly increased specific beneficial taxa (Fusicatenibacter saccharivorans and others)—strong direct evidence.
- Minor Changes in the Composition and Function of the Gut Microbiota During a 12-Week Whole Grain Wheat or Refined Wheat Intervention Correlate with Liver Fat in Overweight and Obese Adults
PubMed ID: 33188417
Whole‑grain wheat (≈+10 g fiber/day) shifted fecal microbiota and predicted butyrate fermentation—supports feeding beneficial bacteria.
- Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
PubMed ID: 35300378
Konjac increased alpha diversity and butyrate‑producing taxa—strong evidence that this fiber feeds good gut bacteria.
- Can guava fruit intake decrease blood pressure and blood lipids?
PubMed ID: 8383769
Guava markedly increased soluble fiber intake; soluble fibers provide substrate for gut microbes — clinical trial showed metabolic benefits consistent with increased fermentable substrate.
- Brown and golden flaxseed reduce intestinal permeability and endotoxemia, and improve the lipid profile in perimenopausal overweight women
PubMed ID: 35311432
Flaxseed decreased endotoxemia and gut permeability and likely modified gut microbial effects — supports prebiotic/ microbiota benefit.
- A maternal higher-complex carbohydrate diet increases bifidobacteria and alters early life acquisition of the infant microbiome in women with gestational diabetes mellitus
PubMed ID: 35966074
Controlled maternal diet higher in complex carbs/higher fiber increased maternal Bifidobacterium and improved infant microbiome richness — direct microbiota feeding evidence.
- Rapid benefits in older age from transition to whole food diet regardless of protein source or fat to carbohydrate ratio: Arandomised control trial
PubMed ID: 39011855
Whole-food diet increased fiber intake and raised plasma acetate (an SCFA produced by bacterial fermentation), consistent with increased fermentation by gut microbes.
- Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention
PubMed ID: 39864520
Randomized inulin (prebiotic) treatment produced clear changes in fecal microbiota and fecal/plasma metabolites tied to microbial activity, directly supporting fiber as a substrate for beneficial gut microbes.
- Effect of type of fiber, site of fermentation, and method of analysis on digestibility of soluble and insoluble fiber in rabbits
PubMed ID: 26115273
Clear changes in ileal/cecal fermentation and mucin with different soluble-fiber levels indicate substantial effects on where and how microbes access substrates.
- An Assessment of the Glyconutrient Ambrotose™ on Immunity, Gut Health, and Safety in Men and Women: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial
PubMed ID: 32545396
Ambrotose is a glyconutrient/prebiotic fiber blend; trial showed immune/gut biomarker changes consistent with prebiotic effects.
- The Impact of Glucomannan, Inulin, and Psyllium Supplementation (Soloways(TM)) on Weight Loss in Adults with FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 38398881
Contains inulin and psyllium (prebiotic fibers) and glucomannan — strong plausibility for feeding beneficial gut bacteria; trial showed clinical benefits.
- Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patients
PubMed ID: 22470031
Study explicitly used inulin/FOS (prebiotics) and observed metabolic/anti‑inflammatory effects in obese men.
- Walnuts and Vegetable Oils Containing Oleic Acid Differentially Affect the Gut Microbiota and Associations with Cardiovascular Risk Factors: Follow-up of a Randomized, Controlled, Feeding Trial in Adults at Risk for Cardiovascular Disease
PubMed ID: 31848609
Walnut diet changed gut microbiota composition (e.g., increased Roseburia) and these changes correlated with cardiometabolic improvements.
- Effect of arabinogalactan on the gut microbiome: A randomized, double-blind, placebo-controlled, crossover trial in healthy adults
PubMed ID: 34004416
Arabinogalactan altered microbiome composition (decreased Firmicutes:Bacteroidetes, shifts in SCFA‑related metabolites) in RCT crossover.
- A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke (Cynara scolymus) in healthy human subjects
PubMed ID: 20591206
Double‑blind cross‑over trial: 10 g globe‑artichoke inulin significantly increased fecal bifidobacteria and lactobacilli—strong direct evidence that this fibre feeds beneficial bacteria.
- Effects of inulin supplementation on body composition and metabolic outcomes in children with obesity
PubMed ID: 35906473
Inulin modestly affected lean mass and within‑study microbiota changes were reported in related trials; moderate evidence that inulin supports beneficial taxa.
- Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity
PubMed ID: 39033197
Six‑month inulin supplementation in obese children produced clear increases in Bifidobacterium abundance and overall microbiota diversity—high‑quality, direct evidence.
- Avocado Consumption Alters Gastrointestinal Bacteria Abundance and Microbial Metabolite Concentrations among Adults with Overweight or Obesity: A Randomized Controlled Trial
PubMed ID: 32805028
Daily avocado shifted microbiota composition (increased Faecalibacterium, Lachnospira, Alistipes) and raised acetate—consistent with prebiotic effects.
- Combining functional features of whole-grain barley and legumes for dietary reduction of cardiometabolic risk: a randomised cross-over intervention in mature women
PubMed ID: 24063257
Barley+legume diet increased breath hydrogen (marker of fermentation) alongside cardiometabolic improvements.
- Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics
PubMed ID: 30046942
Barley kernel bread effects on next‑meal metabolism were tied to baseline microbiota and subgroup differences—supports prebiotic effects.
- Barley β-glucan increases fecal bile acid excretion and short chain fatty acid levels in mildly hypercholesterolemic individuals
PubMed ID: 29872803
HMW β‑glucan increased fecal SCFAs (colonic fermentation) in humans—direct evidence of substrate for beneficial bacteria.
- Alterations in gut microbiota composition and metabolic parameters after dietary intervention with barley beta glucans in patients with high risk for metabolic syndrome development
PubMed ID: 30396006
4‑week β‑glucan bread increased fecal propionate and shifted gut microbiota—clinical evidence of feeding microbiota.
- Anti-Inflammatory Diet Prevents Subclinical Colonic Inflammation and Alters Metabolomic Profile of Ulcerative Colitis Patients in Clinical Remission
PubMed ID: 36014800
Higher fiber intake with an anti‑inflammatory diet was linked to improved fecal inflammatory markers; fiber can support beneficial microbes that reduce inflammation.
- Nutritional and health benefits of a partial substitution of red and processed meat with non-soy legumes: a 6-week randomized controlled trial in healthy working-age men
PubMed ID: 40828321
Legumes increased fiber intake; legumes' fibers/resistant starches are substrates for colonic bacteria (indirect evidence).
- Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial
PubMed ID: 17386092
Model fermentation demonstrated acetate/propionate/butyrate production—direct evidence beta‑glucan is fermentable to SCFAs that feed colonic microbes.
- Modulation of human intestinal microbiota in a clinical trial by consumption of a β-D-glucan-enriched extract obtained from Lentinula edodes
PubMed ID: 33580297
Shiitake β‑glucan altered gut bacterial composition in adults, suggesting selective feeding of taxa.
- Effects of non-digestible carbohydrates on gut microbiota and microbial metabolites: a randomised, controlled dietary intervention in healthy individuals
PubMed ID: 39494600
Resistant starch/polydextrose altered fecal SCFAs (butyrate increases) and BCFA decreases, indicating prebiotic effects.
- Impact of wheat aleurone on biomarkers of cardiovascular disease, gut microbiota and metabolites in adults with high body mass index: a double-blind, placebo-controlled, randomized clinical trial
PubMed ID: 35247098
Aleurone supplementation increased fecal Bifidobacterium abundance (bifidogenic effect).
- Metabolite Biomarkers Linking a High-Fiber Rye Intervention with Cardiometabolic Risk Factors: The RyeWeight Study
PubMed ID: 40838659
High‑fiber rye raised rye‑derived and microbial metabolites associated with beneficial microbial activity.
- Effects of legume kernel fibres and citrus fibre on putative risk factors for colorectal cancer: a randomised, double-blind, crossover human intervention trial
PubMed ID: 24060277
Legume/citrus fibres increased SCFA excretion (marker of microbial fermentation) substantially.
- The formation of short-chain fatty acids is positively associated with the blood lipid-lowering effect of lupin kernel fiber in moderately hypercholesterolemic adults
PubMed ID: 24572041
Lupin fiber increased total SCFA formation, indicating enhanced microbial fermentation.
- Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project
PubMed ID: 39710576
Cereal intervention altered gut microbiota composition (increased specific Bacteroides and butyrate producers); fiber part of mix.
- Apparent fiber digestibility and fecal short-chain fatty acid concentrations with ingestion of two types of dietary fiber
PubMed ID: 8164297
Different dietary fibers substantially increased colonic SCFAs (notably butyrate) indicating fermentation by gut bacteria.
- Randomized clinical trial of Plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis. Spanish Group for the Study of Crohn's Disease and Ulcerative Colitis (GETECCU)
PubMed ID: 10022641
Psyllium increased fecal butyrate in ulcerative colitis patients—supports fermentation and beneficial bacteria activity.
- The effect of wheat bran particle size on laxation and colonic fermentation
PubMed ID: 12038477
Finely ground wheat bran increased fecal butyrate and breath methane—evidence of enhanced fermentation.
- Fecal butyrate levels vary widely among individuals but are usually increased by a diet high in resistant starch
PubMed ID: 21430242
Resistant starch usually raised fecal butyrate and total SCFA, indicating enhanced fermentation by beneficial microbes.
- Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals
PubMed ID: 23977723
Butyrylated resistant starch strongly increased fecal butyrate and selectively increased beneficial bacteria (e.g., F. prausnitzii).
- Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults
PubMed ID: 28179226
Whole‑grain swapping modestly increased stool acetate/total SCFA and altered taxa—consistent with feeding beneficial microbes.
- A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial
PubMed ID: 33388204
Plant-forward diet increased fibre-fermenting and butyrate-producing taxa—dietary pattern including fibre fed good bacteria.
- The prebiotic effects of omega-3 fatty acid supplementation: A six-week randomised intervention trial
PubMed ID: 33382352
Inulin raised circulating butyrate strongly and altered gut genera—evidence of feeding SCFA producers.
- Short-chain fatty acids are key mediators of the favorable effects of the Mediterranean diet on intestinal barrier integrity: data from the randomized controlled LIBRE trial
PubMed ID: 36055959
Mediterranean diet raised fecal propionate/butyrate and improved barrier markers with increased fibre-degrading taxa.
- Substitution of Refined Conventional Wheat Flour with Wheat High in Resistant Starch Modulates the Intestinal Microbiota and Fecal Metabolites in Healthy Adults: A Randomized, Controlled Trial
PubMed ID: 35102419
High-amylose (resistant) wheat increased fecal butyrate and favorable microbial shifts—prebiotic-like effect.
- Associations of Dietary Intake with the Intestinal Microbiota and Short-Chain Fatty Acids Among Young Adults with Type 1 Diabetes and Overweight or Obesity
PubMed ID: 36841667
Higher fiber intake correlated with higher fecal SCFAs and SCFA-producing microbes in young adults with T1D—observational support.
- The prebiotic effects of soluble dietary fiber mixture on renal anemia and the gut microbiota in end-stage renal disease patients on maintenance hemodialysis: a prospective, randomized, placebo-controlled study
PubMed ID: 36517799
Soluble-fiber mix increased serum butyrate and Bifidobacterium/Lactobacillus abundances in hemodialysis patients—clear feeding of beneficial taxa.
- Continuous partially hydrolyzed guar gum intake reduces cold-like symptoms: a randomized, placebo-controlled, double-blinded trial in healthy adults
PubMed ID: 35916813
PHGG raised stool SCFAs and beneficial taxa, consistent with feeding SCFA-producers.
- Additional Resistant Starch from One Potato Side Dish per Day Alters the Gut Microbiota but Not Fecal Short-Chain Fatty Acid Concentrations
PubMed ID: 35277080
Adding a potato side (small RS increase) shifted specific gut taxa including Roseburia faecis (microbiome feeding signal).
- A microbiome-targeting fibre-enriched nutritional formula is well tolerated and improves quality of life and haemoglobin A1c in type 2 diabetes: A double-blind, randomized, placebo-controlled trial
PubMed ID: 36594522
Fiber formula increased butyrate‑producing taxa (Roseburia, Anaerostipes) and improved clinical glycaemic outcomes—strong microbiome support.
- A Symbiotic Meal Containing Extruded Sorghum and Probiotic (Bifidobacterium longum) Ameliorated Intestinal Health Markers in Individuals with Chronic Kidney Disease: A Secondary Analysis of a Subsample from a Previous Randomized and Controlled Clinical Trial
PubMed ID: 38931207
Symbiotic meal increased fecal SCFAs and intra‑group increases in beneficial SCFAs—supports growth/activity of fermenters.
- Quality and quantity of carbohydrates, faecal short-chain fatty acids and gastrointestinal symptoms - results from a randomised, controlled trial (CARBFUNC)
PubMed ID: 39631208
Different carbohydrate/fibre patterns changed stool SCFAs substantially (butyrate increases with some fibers) indicating feeding of fermenters.
- The anti-inflammatory effects of three different dietary supplement interventions
PubMed ID: 41094562
Synbiotic (kefir + prebiotics) increased serum butyrate and changed inflammatory proteins—supports stimulating beneficial microbes.
- Short-chain fatty acid kinetics and concentrations are higher after inulin supplementation in young and older adults: a randomized trial
PubMed ID: 40274191
Inulin 30 g/day robustly increased gut SCFA production and fecal SCFAs in young and older adults (direct feed of fermenters).
- The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
PubMed ID: 40947861
Butyrylated high‑amylose starch markedly increased fecal butyrate (+54%) and lowered pH—strong direct substrate effect on butyrate producers.
- Randomized, double-blinded, placebo-controlled study of effect of wheat bran fiber and calcium on fecal bile acids in patients with resected adenomatous colon polyps
PubMed ID: 8537982
Wheat bran changed fecal bile acid pools substantially over 9 months — indicates strong fermentative/colonic effects consistent with prebiotic/colonic microbiome modulation.
- Non-digestible oligosaccharides and calcium absorption in girls with adequate calcium intakes
PubMed ID: 12088517
Inulin+oligofructose (prebiotic) increased fractional calcium absorption in girls—prebiotic fibers act via colonic fermentation, giving reasonably strong indirect evidence they feed gut bacteria.
- Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis
PubMed ID: 29777234
Demonstrates that baseline microbiome composition modifies weight response to higher-fiber diets, supporting functional interaction between fiber and gut bacteria.
- Impact of chicory inclusion in a cereal-based diet on digestibility, organ size and faecal microbiota in growing pigs
PubMed ID: 23031467
Chicory forage/root in pigs shifted fecal microbiota (fewer coliforms, higher lactobacilli ratio) and increased NSP digestibility — animal evidence of prebiotic effect.
- Effect of chicory inulin-type fructan-containing snack bars on the human gut microbiota in low dietary fiber consumers in a randomized crossover trial
PubMed ID: 32320024
Inulin-type fructans (3–7 g/day) produced a clear, dose-dependent increase in Bifidobacterium in low-fiber adults — direct bifidogenic evidence.
- Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets
PubMed ID: 28808723
Higher whole‑grain (higher fiber) intake raised urinary enterolactone and altered plasma metabolites consistent with microbiota‑driven metabolism.
- [Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study]
PubMed ID: 29378102
Inulin is a known prebiotic; the clinical product improved bowel outcomes consistent with fermentation-driven microbiota effects (though product contained other actives).
- Effects of Resistant Glucan Mixture on Bowel Movement in Female Volunteers
PubMed ID: 27117853
Resistant glucan is a fermentable resistant fiber (prebiotic class) and increased stool output; although microbiota not measured, likely to feed colonic bacteria.
- Effect of organic acids or probiotics alone or in combination on growth performance, nutrient digestibility, enzyme activities, intestinal morphology and gut microflora in broiler chickens
PubMed ID: 29250860
Broiler study showed organic acids/probiotics improved crude fibre digestion and beneficial gut bacteria (Lactobacillus:E. coli) — supports fiber–microbiota interaction (animal model).
- Assessment of DNA damage and its modulation by dietary and genetic factors in smokers using the Comet assay: a biomarker model
PubMed ID: 16076733
Intervention used prebiotic (a form of fiber) bread and showed reduced faecal-water genotoxicity and some biomarkers of benefit consistent with prebiotic action on gut microbiota.
- Diet Quality and Protein-Bound Uraemic Toxins: Investigation of Novel Risk Factors and the Role of Microbiome in Chronic Kidney Disease
PubMed ID: 34776340
Higher fiber intake in CKD associated with gut microbiome shifts and lower uraemic toxins (associative).
- Improved Plasma Lipids, Anti-Inflammatory Activity, and Microbiome Shifts in Overweight Participants: Two Clinical Studies on Oral Supplementation with Algal Sulfated Polysaccharide
PubMed ID: 36005503
SXRG84 trials reported microbiome shifts including increases in beneficial taxa (Akkermansia, Bifidobacterium).
- Two apples a day modulate human:microbiome co-metabolic processing of polyphenols, tyrosine and tryptophan
PubMed ID: 32103319
Two apples/day altered urinary/plasma microbial metabolites (indoles), indicating increased microbial fermentation of fiber‑rich food.
- Association between whole-grain consumption, tryptophan metabolism and psychological distress: a secondary analysis of a randomised controlled trial
PubMed ID: 38826077
Whole‑grain intake (fiber‑rich) associated with higher circulating indole‑propionic acid (microbial metabolite) in a weight management trial → supports fiber feeding beneficial taxa/metabolites.
- Effects of cereal and vegetable fiber feeding on potential risk factors for colon cancer
PubMed ID: 1339081
Different fibres lowered fecal pH and bile acids—biochemical shifts that influence microbiota composition/function.
- Influence of soybean processing, habitual diet, and soy dose on urinary isoflavonoid excretion
PubMed ID: 9848522
Study linked higher fibre/carbohydrate intake to equol production (a microbiota‑mediated transformation) — indirect evidence that fiber correlates with microbial activity.
- Effects of pectin on diarrhea in critically ill tube-fed patients receiving antibiotics
PubMed ID: 11072556
Pectin (soluble fiber) affected stool output and diarrhea incidence, consistent with effects on colonic environment and microbial interactions.
- Clinical studies in persistent diarrhea: dietary management with green banana or pectin in Bangladeshi children
PubMed ID: 11522739
Pectin is a fermentable fibre; green banana and pectin can act as substrates for gut microbes—plausible prebiotic effect though the study focused on diarrhoea outcomes.
- High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial comparison between wheat bran diet and partially hydrolyzed guar gum (PHGG)
PubMed ID: 12184518
PHGG is a soluble fiber likely to be fermentable and better tolerated than bran; RCT showed gut symptom improvements consistent with favorable microbiota effects (not directly measured).
- Phloem fortification in rye bread elevates serum enterolactone level
PubMed ID: 12373614
Rye bread enriched with phloem powder increased serum enterolactone produced by gut bacteria — direct evidence that fibre delivers substrates metabolized by gut microbes.
- [Influence of probiotics and fibre on the incidence of bacterial infections following major abdominal surgery - results of a prospective trial]
PubMed ID: 12436353
Enteral nutrition with fibre and live Lactobacillus markedly lowered postoperative infections; combined evidence supports fibre as substrate for beneficial microbes (though probiotics contributed substantially).
- Effects of fructo-oligosaccharide-supplemented infant cereal: a double-blind, randomized trial
PubMed ID: 13129464
FOS is a known prebiotic; in infants it increased stool frequency/softness — consistent with colonic fermentation and microbiota effects.
- [Early jejunal nutrition with combined pre- and probiotics in acute pancreatitis--prospective, randomized, double-blind investigations]
PubMed ID: 12764986
Oat-fiber substrate given with probiotics in jejunal feeding improved clinical outcomes in pancreatitis; fiber likely provided substrate for probiotic growth, but effect was combined.
- The effect of inulin and sugar beet fibre on oesophagostomum dentatum infection in pigs
PubMed ID: 12885189
In pigs, fermentable fiber (inulin and sugar-beet fiber) produced large biological effects in the gut (reduced worm burden/fecal eggs), consistent with strong fermentative/ microbiota activity (animal model).
- The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans: a double-blind, randomized, placebo-controlled, parallel-group, dose-response relation study
PubMed ID: 15585783
Short‑term human trial: FOS, GOS, resistant starch, etc. increased fecal bifidobacteria significantly—strong prebiotic evidence.
- Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis
PubMed ID: 15122774
Synbiotic/fermentable-fiber treatment significantly increased fecal Lactobacillus and lowered ammonia/endotoxin in cirrhosis patients — direct evidence that fermentable fibers can feed beneficial bacteria (probiotic confounding present).
- A combination of fibre-rich rye bread and yoghurt containing Lactobacillus GG improves bowel function in women with self-reported constipation
PubMed ID: 16251881
High-fibre rye bread altered transit and consistency and adding LGG (probiotic) reduced symptoms — suggests fiber influences microbiota and fermentation-related outcomes.
- Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study
PubMed ID: 17761020
Daily whole-grain wheat increased fecal bifidobacteria and lactobacilli versus wheat bran—strong direct evidence that fiber-rich whole grain feeds beneficial microbes.
- Influence of prebiotics and antioxidants in bread on the immune system, antioxidative status and antioxidative capacity in male smokers and non-smokers
PubMed ID: 17298705
Prebiotic (inulin/linseed/soya) bread changed immune markers and is consistent with prebiotic effects on gut microbiota.
- Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients
PubMed ID: 17308252
Enteral synbiotic (live lactobacilli + bioactive fermentable fibers) reduced intestinal permeability and infections—strong evidence that fermentable fibers support beneficial microbiota effects in patients.
- Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective, randomized, double blind study
PubMed ID: 17523328
The synbiotic product contained multiple prebiotic fibers and produced clinical benefit; prebiotics feed gut bacteria, although probiotics were also administered.
- Comparison of early enteral nutrition in severe acute pancreatitis with prebiotic fiber supplementation versus standard enteral solution: a prospective randomized double-blind study
PubMed ID: 17569144
This trial used prebiotic fiber in enteral feeds; prebiotics are intended to feed beneficial gut microbes and the study showed clinical GI benefits—strong, direct relevance.
- Phylotypes related to Ruminococcus bromii are abundant in the large bowel of humans and increase in response to a diet high in resistant starch
PubMed ID: 18616586
Resistant starch intervention significantly increased Ruminococcus bromii, a key starch-degrading gut bacterium — direct microbiome evidence.
- [The effect of a fibre enriched dietary milk product in chronic primary idiopatic constipation]
PubMed ID: 18372941
Intervention used inulin + resistant maltodextrin (prebiotic fibers) which are known to feed beneficial bacteria; trial showed symptomatic benefit though microbiota not reported.
- [Efficacy of using inulin fortified fermented milk products in patients with functional constipation]
PubMed ID: 19663305
Inulin is a known prebiotic; the fermented-milk/inulin products improved constipation and QoL—consistent with feeding beneficial gut bacteria, though microbial measures were not reported in the summary.
- NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
PubMed ID: 21164548
NUTRIOSE is a resistant dextrin with prebiotic properties; though the RCT did not report microbiota, the fiber is known to be fermentable and feed gut bacteria.
- Clinical trial: the combination of rifaximin with partially hydrolysed guar gum is more effective than rifaximin alone in eradicating small intestinal bacterial overgrowth
PubMed ID: 20937045
Partially hydrolysed guar gum (soluble fiber) improved SIBO treatment outcomes; soluble fibers can alter luminal microbiology and may act as substrates for microbes.
- Linking long-term dietary patterns with gut microbial enterotypes
PubMed ID: 21885731
Clear human evidence: long‑term high‑fiber diets strongly associate with distinct microbiome enterotypes (Prevotella) and affect transit/SCFA—feeds commensals.
- Comparison of high protein and high fiber weight-loss diets in women with risk factors for the metabolic syndrome: a randomized trial
PubMed ID: 21524314
High‑fiber wholefood diet likely increased fermentable substrates for gut bacteria—consistent with feeding beneficial microbes.
- Coarse, but not finely ground, dietary fibre increases intestinal Firmicutes:Bacteroidetes ratio and reduces diarrhoea induced by experimental infection in piglets
PubMed ID: 22018207
Wheat bran in piglets shifted microbiota and increased total VFA—strong mechanistic animal evidence that fiber feeds beneficial microbes.
- Perceptions of flatulence from bean consumption among adults in 3 feeding studies
PubMed ID: 22104320
Bean fermentation produces gas and symptoms that decline with adaptation — evidence that legumes (fiber) are fermented by gut bacteria, indicating prebiotic feeding.
- Effects of NUTRIOSE® dietary fiber supplementation on body weight, body composition, energy intake, and hunger in overweight men
PubMed ID: 21591985
NUTRIOSE is a soluble dietary fiber often acting as a prebiotic; the trial showed appetite/weight effects though microbiota were not reported—plausible but not measured.
- Effect of a mixture of inulin and fructo-oligosaccharide on Lactobacillus and Bifidobacterium intestinal microbiota of patients receiving radiotherapy: a randomised, double-blind, placebo-controlled trial
PubMed ID: 23588438
Inulin+FOS supplementation accelerated recovery of Lactobacillus and Bifidobacterium after pelvic radiotherapy—direct prebiotic effect.
- Microbiota benefits after inulin and partially hydrolized guar gum supplementation: a randomized clinical trial in constipated women
PubMed ID: 22566311
Prebiotic fiber altered gut microbiota in constipated women (reduced Clostridium spp.), demonstrating microbiota modulation.
- Digestive and physiologic effects of a wheat bran extract, arabino-xylan-oligosaccharide, in breakfast cereal
PubMed ID: 22771050
Arabino‑xylan‑oligosaccharide (AXOS) produced dose‑dependent increases in fecal bifidobacteria in a randomized crossover trial.
- Randomised, double-blind and placebo-controlled study of the effect of a synbiotic dairy product on orocecal transit time in healthy adult women
PubMed ID: 23165580
Synbiotic product (fiber + probiotics) stabilized lactic flora and altered transit; combined product supports favorable microbiota changes.
- Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers: a double-blind, randomised, placebo-controlled, cross-over trial
PubMed ID: 22370444
Wheat‑bran extract increased fecal bifidobacteria and SCFA and decreased p‑cresol—direct evidence of microbiota feeding/prebiotic effect in humans.
- Improvement effect of resistant maltodextrin in humans with metabolic syndrome by continuous administration
PubMed ID: 23419401
Resistant maltodextrin produced metabolic benefits; as a resistant fiber it likely has prebiotic effects though microbiota outcomes were not the primary endpoint in this trial.
- Impact of a resistant dextrin on intestinal ecology: how altering the digestive ecosystem with NUTRIOSE®, a soluble fibre with prebiotic properties, may be beneficial for health
PubMed ID: 22429361
Two randomized, placebo‑controlled trials showed NUTRIOSE® (resistant dextrin) increased beneficial Bacteroides and reduced C. perfringens—strong prebiotic evidence.
- Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial
PubMed ID: 24332524
Oligofructose-enriched inulin is a prebiotic; trial showed reductions in plasma LPS and inflammation consistent with beneficial microbiota effects.
- In vitro degradation and fermentation of three dietary fiber sources by human colonic bacteria
PubMed ID: 23556460
In vitro fermentations from human fecal inocula showed distinct SCFA/gas patterns by fiber type; mechanistic support that fiber feeds gut bacteria.
- Daily consumption of a synbiotic yogurt decreases energy intake but does not improve gastrointestinal transit time: a double-blind, randomized, crossover study in healthy adults
PubMed ID: 23787118
Synbiotic yogurt contained inulin (a prebiotic fiber) and maintained/higher fiber intake, supportive of feeding beneficial bacteria.
- [Clinical benefits after soluble dietary fiber supplementation: a randomized clinical trial in adults with slow-transit constipation]
PubMed ID: 25623312
Pectin increased Bifidobacterium and Lactobacillus and decreased some Clostridium species in constipated patients.
- Effect of increasing dietary fiber on plasma levels of colon-derived solutes in hemodialysis patients
PubMed ID: 25147155
Resistant‑starch RCT (fermentable fiber) reduced uremic microbial toxins (indoxyl sulfate) in dialysis patients—strong evidence of beneficial microbial effects.
- Effects of different amounts of konjac flour inclusion in gestation diets on physio-chemical properties of diets, postprandial satiety in pregnant sows, lactation feed intake of sows and piglet performance
PubMed ID: 25466211
Konjac increased postprandial SCFA in sows — SCFA production indicates fermentation by beneficial gut microbes (animal evidence).
- Effect of inulin and fructo-oligosaccharide on the prevention of acute radiation enteritis in patients with gynecological cancer and impact on quality-of-life: a randomized, double-blind, placebo-controlled trial
PubMed ID: 26603881
Intervention used inulin+FOS, established prebiotics that selectively feed beneficial gut bacteria; trial showed stool and QoL effects consistent with prebiotic activity.
- α-Galacto-oligosaccharides Dose-Dependently Reduce Appetite and Decrease Inflammation in Overweight Adults
PubMed ID: 26180243
α‑GOS is a prebiotic fiber; intervention lowered plasma LPS and CRP while increasing satiety—consistent with beneficial microbiota/metabolic effects.
- Dietary protein-fiber ratio associates with circulating levels of indoxyl sulfate and p-cresyl sulfate in chronic kidney disease patients
PubMed ID: 26026209
Observational CKD study: higher dietary fiber (lower protein:fiber ratio) associated with lower gut‑derived uremic toxins (PCS, IS), implying fiber benefits to gut microbial metabolism.
- Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial
PubMed ID: 26529006
Fructan-supplemented infant formula markedly increased Bifidobacterium abundance (clear bifidogenic/prebiotic effect).
- Safety, growth, and support to healthy gut microbiota by an infant formula enriched with functional compounds
PubMed ID: 26718667
Infant formula enriched with galacto‑oligosaccharides (prebiotic fiber) significantly increased fecal Bifidobacteria counts (direct evidence).
- [Efficacy of pectin in the treatment of diarrhea predominant irritable bowel syndrome]
PubMed ID: 25809332
Pectin increased fecal bifidobacteria in IBS‑D patients (RCT evidence of prebiotic effect).
- [DIETARY SUPPLEMENT REKECEN IMPROVES SAFETY AND EFFICACY OF CHRONIC PROSTATITIS ANTIBACTERIAL THERAPY]
PubMed ID: 26094394
Fermented fiber+SCFA formulation (prebiotic/fermented components) given with antibiotics had beneficial GI effects, consistent with microbiota‑targeted action.
- Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial
PubMed ID: 27810310
Study tested a prebiotic fiber (polydextrose) combined with probiotic B420 — intended to feed/augment beneficial microbiota and produced metabolic effects.
- A Randomized Controlled Trial to Increase Navy Bean or Rice Bran Consumption in Colorectal Cancer Survivors
PubMed ID: 27689688
Navy‑bean and rice bran increased fiber intake in CRC survivors; these fibers are plausible substrates for gut microbes and changed some inflammatory markers.
- Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of adults with irritable bowel syndrome: A randomized double-blind, placebo-controlled trial
PubMed ID: 27157575
Synbiotic with inulin transiently increased administered probiotic strain abundance in stool—shows fermentable fiber (inulin) supports probiotic survival/expansion transiently.
- Impact of increasing fruit and vegetables and flavonoid intake on the human gut microbiota
PubMed ID: 26757793
Increasing fruit/vegetable intake (fiber/flavonoids) changed specific gut bacteria and correlated with markers—evidence that dietary fiber shifts taxa.
- Probiotics and prebiotic fiber for constipation associated with Parkinson disease: An RCT
PubMed ID: 27543643
Fermented milk product combined with prebiotic fiber increased bowel movements; prebiotic component suggests feeding of beneficial bacteria though the combined intervention complicates attribution.
- Effects of scFOS on the composition of fecal microbiota and anxiety in patients with irritable bowel syndrome: a randomized, double blind, placebo controlled study
PubMed ID: 27477485
scFOS intervention directly increased fecal Bifidobacteria (significant) — strong evidence that this fermentable fiber feeds beneficial gut bacteria.
- A randomised, double-blind, placebo-controlled clinical study: the effects of a synbiotic, Lepicol, in adults with chronic, functional constipation
PubMed ID: 27776217
Product combined psyllium (fiber) and inulin (prebiotic) with probiotics and increased bowel frequency and QoL; inulin portion likely fed gut bacteria though probiotics confound attribution.
- Oligofructose Provides Laxation for Irregularity Associated with Low Fiber Intake
PubMed ID: 29258261
Oligofructose (a prebiotic) increased bowel frequency and improved GI sensations; oligofructose is known to feed beneficial gut microbes.
- Replacement of glycaemic carbohydrates by inulin-type fructans from chicory (oligofructose, inulin) reduces the postprandial blood glucose and insulin response to foods: report of two double-blind, randomized, controlled trials
PubMed ID: 28255654
Inulin/oligofructose replacements reduce glycemic responses and are established fermentable substrates for gut bacteria (prebiotic).
- Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals
PubMed ID: 28396144
GOS (fermentable fiber) increased fecal Bifidobacterium abundance ~5-fold (strong direct prebiotic evidence).
- Chain length-dependent effects of inulin-type fructan dietary fiber on human systemic immune responses against hepatitis-B
PubMed ID: 28586162
Long-chain inulin-type fructans (prebiotic fiber) altered immune responses and are known to stimulate beneficial gut microbes (supported by study).
- Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study
PubMed ID: 28705786
Product was a synbiotic containing prebiotic fiber; improvements in constipation could partly reflect prebiotic effects on microbiota (cannot separate from probiotic).
- Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention
PubMed ID: 28883543
High‑fiber diet produced greater fat loss in persons with a high Prevotella/Bacteroides ratio, implicating microbiome interactions.
- Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics
PubMed ID: 29954454
GOS (prebiotic) and synbiotic interventions significantly increased bifidobacteria in obese adults.
- In healthy adults, resistant maltodextrin produces a greater change in fecal bifidobacteria counts and increases stool wet weight: a double-blind, randomized, controlled crossover study
PubMed ID: 30527258
25 g resistant maltodextrin increased fecal bifidobacteria counts in healthy adults
- Impact of dietary fiber supplementation on modulating microbiota-host-metabolic axes in obesity
PubMed ID: 30572270
Pea fiber supplementation increased SCFA-producing bacteria and altered fecal metabolites
- Could resistant starch supplementation improve inflammatory and oxidative stress biomarkers and uremic toxins levels in hemodialysis patients? A pilot randomized controlled trial
PubMed ID: 30468238
Resistant starch (a fermentable fiber) reduced indoxyl sulfate and inflammation—consistent with beneficial fermentation and microbial shifts.
- The effect of prunes on stool output, gut transit time and gastrointestinal microbiota: A randomised controlled trial
PubMed ID: 29398337
Prune (high-fiber) increased stool output—dietary changes that influence the gut environment and microbial activity.
- A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects
PubMed ID: 30541093
Whole‑grain wheat preserved gut microbiota diversity over 12 weeks vs refined wheat—direct microbiota evidence.
- Mediation Analysis as a Means of Identifying Dietary Components That Differentially Affect the Fecal Microbiota of Infants Weaned by Modified Baby-Led and Traditional Approaches
PubMed ID: 30006390
Infant feeding trial found dietary fiber explained ~25% of differences in gut microbiota diversity at 12 months, indicating fiber's role in shaping microbiota.
- Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study
PubMed ID: 29307330
RCT showed inulin prebiotic increased Bifidobacterium and Faecalibacterium (in high-fiber habitual eaters) — direct evidence that certain fibers feed beneficial taxa.
- A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
PubMed ID: 30425247
Cereal‑fiber composition changes altered the gut microbiome (notably Bifidobacterium spp.), showing fiber composition influences beneficial taxa.
- Impact of Agaricus bisporus Mushroom Consumption on Gut Health Markers in Healthy Adults
PubMed ID: 30279332
Mushroom feeding shifted fecal microbiota composition even over a short period—supports microbiota modulation by low‑digestible carbs.
- Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial
PubMed ID: 31509971
PHGG increased Bifidobacterium and improved stool form—clear evidence of selectively feeding beneficial bacteria.
- Effect of prebiotic (fructooligosaccharide) on uremic toxins of chronic kidney disease patients: a randomized controlled trial
PubMed ID: 29939302
12‑week FOS (prebiotic) in CKD trended toward lowering p‑cresyl sulfate, consistent with microbiota-modulating effects.
- Prevotella Abundance Predicts Weight Loss Success in Healthy, Overweight Adults Consuming a Whole-Grain Diet Ad Libitum: A Post Hoc Analysis of a 6-Wk Randomized Controlled Trial
PubMed ID: 31504699
Higher Prevotella abundance predicted better weight loss on a higher-fiber whole-grain diet, indicating fiber-microbiota interactions.
- Pretreatment Prevotella-to-Bacteroides ratio and salivary amylase gene copy number as prognostic markers for dietary weight loss
PubMed ID: 32034403
Dietary fiber‑rich New Nordic Diet outcomes depended on Prevotella/Bacteroides ratios, demonstrating fiber–microbiome interactions that influence clinical response.
- Altered gut microbiome function in ADHD: More Prevotella, less vitamin B12 biosynthesis, and beneficial modulation by synbiotic treatment
PubMed ID: 41500324
Synbiotic intervention (contains fibres) changed gut microbiome composition and increased certain plasma SCFAs—direct evidence of microbiome modulation.
- Pilot investigation of an oligosaccharide blend in adults with asthma - a double-blind, randomised, placebo-controlled, 4-arm crossover trial
PubMed ID: 41192744
Soluble oligosaccharide blend increased plasma SCFAs (marker of fermentation), indicating prebiotic feeding of gut microbes.
- Agrarian diet improves metabolic health in HIV-positive men with Prevotella-rich microbiomes: results from a randomized trial
PubMed ID: 41294355
Agrarian high‑fibre diet modulated microbiome composition (response linked to Prevotella status).
- Resistant starch improves Parkinson's disease symptoms through restructuring of the gut microbiome and modulating inflammation
PubMed ID: 41389850
Resistant starch markedly increased Faecalibacterium spp. and SCFAs and reduced opportunistic pathogens—strong direct microbiome evidence.
- Tolerance of high fibre supplementation among participants in a randomised trial to reduce cancer risk among Alaska Native peoples: Alaska FIRST
PubMed ID: 40999949
High resistant‑starch (a fermentable fiber) produced fermentative effects and symptom changes consistent with microbiota activity.
- Inulin supplementation modulates gut microbiota derived metabolites related to brain function in children with obesity
PubMed ID: 41057493
Inulin supplementation changed gut microbiota and raised gut‑derived metabolites in children with obesity.
- Childhood Obesity Body Mass Index and Gut Microbiome: A Cluster Randomized Controlled Pilot Feasibility Study
PubMed ID: 40106235
Prebiotic fiber in a school program induced microbiome changes (↓Tenericutes, ↑Actinobacteria) that were associated with lower BMI.
- Food- vs. supplement-based very-low-energy diets and gut microbiome composition in women with high body mass index: A randomized controlled trial
PubMed ID: 41075788
Food‑based (higher fiber/food matrix) VLED increased species diversity and richness vs supplement‑based VLED.
- Baseline intestinal microbiota composition influences response to a real-world dietary fiber intervention
PubMed ID: 41198696
Resistant starch and inulin induced cluster‑dependent microbiome shifts and increased SCFA proportions (inulin ↑ propionate).
- Probiotics and dietary fibre fermented milk supplementation initiated in the first trimester to prevent gestational diabetes mellitus in overweight and obese pregnant women: A randomized controlled trial
PubMed ID: 40988566
Probiotic+dietary‑fiber fermented milk started in pregnancy altered microbiota and lowered GDM risk; fiber was part of the product.
- Effects of combined prebiotic fiber supplementation and weight loss counseling in adults with metabolic dysfunction-associated steatotic liver disease: a randomized controlled trial
PubMed ID: 40172664
Oligofructose‑enriched inulin increased Bifidobacterium abundance—classic prebiotic effect.
- Gut microbiome predicts personalized responses to dietary fiber in prediabetes: a randomized, open-label trial
PubMed ID: 41390484
Fiber supplement RCT included microbiome‑based responder prediction and linked baseline microbiota to glycemic response—strong microbiome signal.
- A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial
PubMed ID: 39843443
Legume diet induced early enrichment of canonical fibre‑associated taxa (Eubacterium rectale, Roseburia, Bifidobacterium) and metabolite changes.
- Personalized Microbial Fingerprint Associated with Differential Glycemic Effects of a Whole Grain Rye Intervention on Chinese Adults
PubMed ID: 39091068
Whole‑grain rye RCT found baseline microbiome predicted glycemic response and rye increased Faecalibacterium in responders—evidence that this fiber modulates gut bacteria composition/function.
- [Multi-strain probiotic combined with dietary fiber is an effective factor in the nutritional support of immunity in athletes]
PubMed ID: 38809796
Intervention explicitly combined multi‑strain probiotic with substantial corn‑bran (40 g/day) and reported immune/marker improvements compared with placebo+maltodextrin—direct evidence that added fiber with probiotic can alter gut ecosystem and downstream markers.
- A Randomized, Double-Blind, Placebo-Controlled Trial: Efficacy of Opuntia ficus-indica Prebiotic Supplementation in Subjects with Gut Dysbiosis
PubMed ID: 38474715
Opuntia extract increased bifidobacteria and decreased F/B ratio, showing direct prebiotic effects.
- The impact of daily supplementation with rhamnogalacturonan-I on the gut microbiota in healthy adults: A randomized controlled trial
PubMed ID: 38593705
Very low‑dose carrot rhamnogalacturonan‑I significantly increased Bifidobacterium abundance and stabilized microbiota.
- Adaptation to tolerate high doses of arabinoxylan is associated with fecal levels of Bifidobacterium longum
PubMed ID: 38860973
High‑dose arabinoxylan associated with increased B. longum and acetate/acidification linked to better tolerance—clear microbiome feeding effect.
- Comprehensive modulatory effects of whole grain consumption on immune-mediated inflammation in middle-aged and elderly community residents: A real-world randomized controlled trial
PubMed ID: 39260062
Whole‑grain staple substitution increased fecal butyrate proportion and altered T‑cell profiles — clear evidence of beneficial fermentation shifts.
- Effects of a diverse prebiotic fibre supplement on HbA1c, insulin sensitivity and inflammatory biomarkers in pre-diabetes: a pilot placebo-controlled randomised clinical trial
PubMed ID: 38654680
Diverse prebiotic fiber supplement changed metabolic/inflammatory markers and likely acted via microbiome fermentation (trial of prebiotic fibers).
- Beneficial Effects of Synbiotics on the Gut Microbiome in Individuals with Low Fiber Intake: Secondary Analysis of a Double-Blind, Randomized Controlled Trial
PubMed ID: 38999830
Synbiotic (probiotic + agave‑inulin) increased abundance of SCFA‑producing taxa in low‑fiber participants in a randomized crossover trial.
- Type 3 resistant starch from Canna edulis reduce lipid levels in patients with mild hyperlipidemia through altering gut microbiome: A double- blind randomized controlled trial
PubMed ID: 38825157
Resistant starch altered gut microbiota/metabolites consistent with lipid metabolism changes in the hyperlipidemic RCT.
- Impact of resistant starch type 3 on fecal microbiota and stool frequency in Thai adults with chronic constipation randomized clinical trial
PubMed ID: 39543201
RS‑3 increased relative abundance of Bifidobacterium and Prevotella in adults with chronic constipation, demonstrating prebiotic effects.
- Effect of Intake of Bifidobacteria and Dietary Fiber on Resting Energy Expenditure: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparison Study
PubMed ID: 39064788
B. animalis + inulin increased fecal bifidobacteria vs placebo in a double‑blind RCT, showing inulin’s prebiotic effect.
- Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial
PubMed ID: 37793780
High‑dose inulin increased Bifidobacterium abundance in overweight adults—direct prebiotic effect.
- Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota
PubMed ID: 38409604
Resistant starch altered gut microbiota and metabolites as part of a trial that also transferred benefits via microbiota to mice.
- Low-protein diet supplemented with inulin lowers protein-bound toxin levels in patients with stage 3b-5 chronic kidney disease: a randomized controlled study
PubMed ID: 37409723
Inulin supplementation lowered protein‑bound uremic toxins (IS, PCS) in CKD—consistent with prebiotic effects on gut microbiota metabolism.
- Agave tequilana Fructans Versus Psyllium plantago for Functional Constipation : Randomized Double-blind Clinical Trial
PubMed ID: 37389917
Agave fructans are prebiotic; trial showed symptomatic benefits though microbiome endpoints not primary—plausible effect on good bacteria.
- Oral Supplementation with Algal Sulphated Polysaccharide in Subjects with Inflammatory Skin Conditions: A Randomised Double-Blind Placebo-Controlled Trial and Baseline Dietary Differences
PubMed ID: 37504910
Seaweed prebiotic (SXRG84) altered specific gut genera (increased Fusicatenibacter, Parabacteroides, Collinsella) in some participants.
- Effect of Continuous Ingestion of Bifidobacteria and Dietary Fiber on Improvement in Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 37836458
B. animalis + inulin increased fecal bifidobacteria significantly over 12 weeks—direct evidence that a fermentable fiber feeds good bacteria.
- The Effects of Agave Fructans in a Functional Food Consumed by Patients with Irritable Bowel Syndrome with Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 37630717
Agave fructans are fermentable prebiotics; improved IBS‑C outcomes likely accompanied by microbiota effects (prebiotic mechanism).
- Effects of Synbiotic Supplementation on Metabolic Syndrome Traits and Gut Microbial Profile among Overweight and Obese Hong Kong Chinese Individuals: A Randomized Trial
PubMed ID: 37836532
Fiber‑rich diet plus synbiotic generated favorable microbiota shifts associated with weight loss and glycemic improvements.
- Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial
PubMed ID: 37078654
Large functional‑constipation RCT showed increases in Bifidobacterium with fiber formulas—direct prebiotic effect.
- Colonic Microbiota Profile Characterization of the Responsiveness to Dietary Fibre Treatment in Hypercholesterolemia
PubMed ID: 35276884
Two‑month fibre‑cookie supplementation increased fecal Bifidobacterium and SCFAs in responders—direct prebiotic effect.
- Facilitating a high-quality dietary pattern induces shared microbial responses linking diet quality, blood pressure, and microbial sterol metabolism in caregiver-child dyads
PubMed ID: 36457073
High‑fiber intervention altered microbiome‑derived sterol elimination and microbial composition linked to BP changes.
- Oligofructose-Enriched Inulin Intake, Gut Microbiome Characteristics, and the V̇O2 Peak Response to High-Intensity Interval Training in Healthy Inactive Adults
PubMed ID: 34910161
Oligofructose‑enriched inulin increased Bifidobacterium abundance during HIIT—direct prebiotic stimulation of beneficial taxa.
- Increasing the diversity of dietary fibers in a daily-consumed bread modifies gut microbiota and metabolic profile in subjects at cardiometabolic risk
PubMed ID: 35311446
Multi‑fiber bread altered gut microbiota composition (increased Parabacteroides distasonis, others) and CAZyme families—direct prebiotic/microbiome effect.
- Effect of oat or rice flour on pulse-induced gastrointestinal symptoms and breath hydrogen in subjects sensitive to pulses and controls - a randomised cross-over trial with two parallel groups
PubMed ID: 35086570
Oat flour increased breath hydrogen AUC (colonic fermentation) and was tolerated—evidence of fermentation by gut microbes.
- Kitchen Diet vs. Industrial Diets-Impact on Intestinal Barrier Parameters among Stroke Patients
PubMed ID: 35627704
Blenderized enteral diet altered stool SCFAs and reduced zonulin versus formula; suggests fiber‑related microbial effects.
- Effect of a Nutritional Support System to Increase Survival and Reduce Mortality in Patients with COVID-19 in Stage III and Comorbidities: A Blinded Randomized Controlled Clinical Trial
PubMed ID: 35162195
Intervention included 20 g inulin + probiotics; strong prebiotic component expected to feed beneficial gut bacteria and was central to the study.
- Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial
PubMed ID: 33561964
Rice bran intake increased Lactobacillus and Firmicutes abundance in adults — direct RCT evidence that a fiber‑rich food feeds beneficial microbiota.
- Effects of ID-HWS1000 on the Perception of Bowel Activity and Microbiome in Subjects with Functional Constipation: A Randomized, Double-Blind Placebo-Controlled Study
PubMed ID: 34406877
Synbiotic product with fibre shifted microbiome family‑level composition and improved bowel symptoms.
- Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men
PubMed ID: 33629506
20 g/day fibre altered gut microbes (increase in Parabacteroides distasonis) and SCFAs → clear microbiome impact.
- The effect of dietary fiber (oat bran) supplement on blood pressure in patients with essential hypertension: A randomized controlled trial
PubMed ID: 34090773
Oat‑bran supplement increased Bifidobacterium and changed gut microbiota composition alongside BP effects.
- Gut-microbiota-targeted diets modulate human immune status
PubMed ID: 34256014
High‑fiber diet increased microbiome CAZyme abundance and changed fecal metabolites, indicating increased community carbohydrate‑processing ability.
- Ingestion of Helianthus tuberosus at Breakfast Rather Than at Dinner Is More Effective for Suppressing Glucose Levels and Improving the Intestinal Microbiota in Older Adults
PubMed ID: 33022987
Inulin supplement shifted gut microbiota composition and increased lactic acid; clear prebiotic effect in a human trial.
- Prebiotic potencial of juçara berry on changes in gut bacteria and acetate of individuals with obesity
PubMed ID: 32108262
Juçara (berry; contains fiber) raised fecal acetate and beneficial bacteria including Bifidobacterium and Akkermansia (human study though multiple components present).
- Effect of a functional fibre supplement on glycemic control when added to a year-long medically supervised weight management program in adults with type 2 diabetes
PubMed ID: 32642971
PGX altered relative abundance of specific genera (Collinsella, Parabacteroides, Roseburia) in a large trial (microbiota effect).
- Resistant starch supplementation increases crypt cell proliferative state in the rectal mucosa of older healthy participants
PubMed ID: 32279690
Resistant starch increased faecal SCFAs and changes correlated with crypt cell proliferation — strong mechanistic evidence of fermentable fiber feeding colonic bacteria.
- Using compositional principal component analysis to describe children's gut microbiota in relation to diet and body composition
PubMed ID: 31711093
Cross‑sectional data linked higher fiber intake with specific child microbiota patterns (Faecalibacterium/Eubacterium/Roseburia), supporting fiber as a substrate for beneficial taxa.
- Efficacy of Polydextrose Supplementation on Colonic Transit Time, Bowel Movements, and Gastrointestinal Symptoms in Adults: A Double-Blind, Randomized, Placebo-Controlled Trial
PubMed ID: 30791557
Polydextrose is a soluble, fermentable fiber (prebiotic) and improved bowel function—consistent with feeding beneficial bacteria.
- Effect of Synbiotic Supplementation in a Very-Low-Calorie Ketogenic Diet on Weight Loss Achievement and Gut Microbiota: A Randomized Controlled Pilot Study
PubMed ID: 31298466
Synbiotic (probiotic + prebiotic fiber) increased SCFA-producing taxa and altered microbiota composition in obese patients on VLCKD (pilot RCT).
- Pretreatment Prevotella-to-Bacteroides ratio and markers of glucose metabolism as prognostic markers for dietary weight loss maintenance
PubMed ID: 31285554
Habitual fiber intake interacted with Prevotella/Bacteroides ratio to influence weight regain; demonstrates fiber's role shaping microbiome with clinical effects.
- Daily intake of wheat germ-enriched bread may promote a healthy gut bacterial microbiota: a randomised controlled trial
PubMed ID: 31325040
Wheat germ added to bread increased Bacteroides and Bifidobacterium — direct evidence of feeding beneficial taxa.
- The effect of inulin and resistant maltodextrin on weight loss during energy restriction: a randomised, placebo-controlled, double-blinded intervention
PubMed ID: 31605197
Daily inulin + resistant maltodextrin changed gut bacterial composition and is a prebiotic combination—strong direct evidence of feeding beneficial microbes.
- Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort
PubMed ID: 32369545
Prospective associations for fiber and health are consistent with beneficial microbiome-mediated mechanisms, though the study did not directly test microbiota in most endpoints.
- Effect of wheat bran derived prebiotic supplementation on gastrointestinal transit, gut microbiota, and metabolic health: a randomized controlled trial in healthy adults with a slow gut transit
PubMed ID: 31983281
Wheat‑bran oligosaccharide supplement increased Bifidobacterium abundance in a 12‑week RCT—clear prebiotic effect.
- Effects of whole-grain wheat, rye, and lignan supplementation on cardiometabolic risk factors in men with metabolic syndrome: a randomized crossover trial
PubMed ID: 32097450
Whole‑grain rye increased bifidobacteria vs wheat in a crossover diet study—supports fermentable‑fiber microbiota benefit.
- Diet-Associated Inflammation Modulates Inflammation and WNT Signaling in the Rectal Mucosa, and the Response to Supplementation with Dietary Fiber
PubMed ID: 33115783
Resistant starch and polydextrose supplementation modulated rectal mucosal markers and interactions with baseline diet, showing direct prebiotic/host‑microbiota effects.
- Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial
PubMed ID: 32521538
Colon‑delivered SCFAs (products of bacterial fermentation of fiber) produced physiological effects, supporting the importance of fermentation products.
- The Effect of Soluble Fiber Dextrin on Subjective and Physiological Markers of Appetite: A Randomized Trial
PubMed ID: 33143121
Soluble resistant dextrin increased breath hydrogen (clear fermentation) indicating colonic fermentation/prebiotic activity.
Bowel regularity (165)
- Chickpea supplementation in an Australian diet affects food choice, satiety and bowel health
PubMed ID: 19945492
Chickpea supplementation improved perceived bowel function, including measures related to regularity.
- Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial
PubMed ID: 19713235
Large RCT: psyllium (soluble fiber) provided greater symptom relief than placebo in IBS; soluble fiber like psyllium is effective for constipation-predominant symptoms.
- Fecal incontinence in obese women with urinary incontinence: prevalence and role of dietary fiber intake
PubMed ID: 19136088
Low fiber intake associated with increased fecal incontinence and bowel issues, implying adequate fiber supports manageable bathroom routines.
- [The effect of a fibre enriched dietary milk product in chronic primary idiopatic constipation]
PubMed ID: 18372941
Randomized double-blind: soluble-fibre-enriched milk (20 g/day) reduced straining and improved evacuation — direct, high-quality evidence reducing constipation.
- [Effect of partially hidrolized guar-gum in the treatment of functional constipation among hospitalized patients]
PubMed ID: 18425236
Clear, direct trial evidence that a high‑fiber diet markedly reduced constipation rates in hospitalized adults.
- Intervention with dietary fiber to treat constipation and reduce laxative use in residents of nursing homes
PubMed ID: 18382081
Oat-bran led to discontinuation of laxatives in 59% of residents—strong, clinically relevant anti-constipation effect.
- A dietary fiber mixture versus lactulose in the treatment of childhood constipation: a double-blind randomized controlled trial
PubMed ID: 18979582
Randomized trial in children: fiber mix performed similarly to lactulose for constipation outcomes.
- Efficacy of long term cyclic administration of the poorly absorbed antibiotic Rifaximin in symptomatic, uncomplicated colonic diverticular disease
PubMed ID: 17226906
Fiber-alone arm yielded sustained symptom improvements over 24 months, consistent with easier bowel movements and bathroom routines.
- Yoghurt containing galacto-oligosaccharides, prunes and linseed reduces the severity of mild constipation in elderly subjects
PubMed ID: 17299467
Elderly subjects with mild constipation experienced increased bowel movements and easier defecation with a fiber‑containing yogurt (randomized crossover).
- A combination of fibre-rich rye bread and yoghurt containing Lactobacillus GG improves bowel function in women with self-reported constipation
PubMed ID: 16251881
Direct improvements in stool frequency, softness and reduced defecation difficulty with rye bread indicate easier bathroom trips.
- Prospective randomized crossover trial comparing fibre with lactulose in the treatment of idiopathic chronic constipation
PubMed ID: 16773290
Fiber led to increased stool frequency in constipated patients though less effectively than lactulose.
- Biofeedback is superior to laxatives for normal transit constipation due to pelvic floor dyssynergia
PubMed ID: 16530506
Initial fiber use in constipation management suggests practical benefit for easier bowel movements.
- A controlled, randomized, double-blind trial to evaluate the effect of a supplement of cocoa husk that is rich in dietary fiber on colonic transit in constipated pediatric patients
PubMed ID: 16950955
Cocoa-husk fiber decreased hard stools and improved transit in constipated children—strong direct evidence for relieving constipation.
- Partially hydrolysed guar gum supplemented comminuted chicken diet in persistent diarrhoea: a randomised controlled trial
PubMed ID: 15665181
Guar gum reduced stool frequency in persistent diarrhoea, reflecting normalization toward regular bowel habits.
- Effects of flax fiber on laxation and glycemic response in healthy volunteers
PubMed ID: 16379563
Flax fiber produced fecal bulking (~2.9 g feces per g fiber), directly relevant to relieving constipation.
- Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A multicenter randomized open trial
PubMed ID: 15986863
PHGG improved IBS symptoms and QoL while taken, implying easier bowel habits for patients.
- Fibre-supplemented tube feeding in the hospitalised elderly
PubMed ID: 15569656
Strong RCT evidence: fibre group had significantly fewer weekly stools and firmer consistency versus control—direct evidence for increased regularity.
- Fiber (glucomannan) is beneficial in the treatment of childhood constipation
PubMed ID: 14993586
Randomized trial: glucomannan markedly increased successful treatment rates in constipated children (direct, strong evidence).
- Effects of a high-fiber diet on symptoms of irritable bowel syndrome: a randomized clinical trial
PubMed ID: 15325678
Fiber interventions in IBS led to improved bowel scores from baseline (some regularity benefit).
- Probiotics, soluble fiber, and L-Glutamine (GLN) reduce nelfinavir (NFV)- or lopinavir/ritonavir (LPV/r)-related diarrhea
PubMed ID: 15768732
Combination fiber/probiotic reduced stool frequency and need for antipropulsives in HIV patients (regularity improved).
- The efficacy of cisapride vs. placebo and diet in patients with chronic constipation
PubMed ID: 12974147
Direct clinical evidence: a fiber-rich diet phase substantially increased weekly stool frequency and reduced straining/incomplete evacuation in chronic constipation patients.
- Fecal bile acid concentrations in a subpopulation of the wheat bran fiber colon polyp trial
PubMed ID: 12646507
Wheat‑bran produced changes in fecal composition over time that are compatible with reduced constipation risk.
- Effects of fructo-oligosaccharide-supplemented infant cereal: a double-blind, randomized trial
PubMed ID: 13129464
FOS increased stool frequency (+26%) and softened stools in a randomized trial — strong support for regularity (in infants).
- [Influence of probiotics and fibre on the incidence of bacterial infections following major abdominal surgery - results of a prospective trial]
PubMed ID: 12436353
Enteral nutrition with fibre + probiotics improved postoperative GI outcomes—supports easier bowel function in clinical feeding contexts (combined therapy).
- Rifaximin improves symptoms of acquired uncomplicated diverticular disease of the colon
PubMed ID: 12458383
Glucomannan (a bulking/soluble fiber) relieved diverticular symptoms and is commonly effective for constipation-related complaints.
- High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial comparison between wheat bran diet and partially hydrolyzed guar gum (PHGG)
PubMed ID: 12184518
PHGG improved bowel habits in IBS patients vs wheat bran, supporting increased regularity.
- Clinical studies in persistent diarrhea: dietary management with green banana or pectin in Bangladeshi children
PubMed ID: 11522739
Pectin/green banana rapidly restored normal stool patterns in infants with persistent diarrhoea—direct evidence of improved regularity in that setting.
- Supplementation with dietary fiber improves fecal incontinence
PubMed ID: 11480529
Marked reduction in incontinent, loose stools and improved stool form reduces unexpected/urgent bathroom trips.
- Randomized clinical trial of soy formula with and without added fiber in antibiotic-induced diarrhea
PubMed ID: 11598607
Soy-fibre formula halved diarrhea duration in children, directly reducing frequency/duration of bathroom trips during illness.
- Long-term effect of fibre supplement and reduced energy intake on body weight and blood lipids in overweight subjects
PubMed ID: 11294130
Fibre supplement RCT significantly altered weight under calorie restriction and would plausibly affect bowel habits; direct effect on bathroom trip ease not reported but likely.
- Effects of wheat bran and Olestra on objective measures of stool and subjective reports of GI symptoms
PubMed ID: 10811335
Controlled feeding study: 20 g/day wheat bran nearly doubled stool output and modestly increased bowel movement frequency (+0.4 BM/day).
- Water supplementation enhances the effect of high-fiber diet on stool frequency and laxative consumption in adult patients with functional constipation
PubMed ID: 9684123
Strong RCT evidence that a 25 g/day high‑fibre diet improved constipation and reduced laxative dependence (p<0.001 with added fluids).
- Use of soy fiber in acute diarrhea in infants and toddlers
PubMed ID: 9078414
Shorter diarrheal episodes in infants imply quicker resolution and easier management of bowel trips during illness.
- The effect of dietary fiber on bowel function following radical hysterectomy: a randomized trial
PubMed ID: 9299255
High‑fiber dietary advice after radical hysterectomy significantly increased bowel movement frequency and reduced laxative use — direct, strong evidence for improved regularity.
- Lower serum oestrogen concentrations associated with faster intestinal transit
PubMed ID: 9252210
Wheat bran (≈19.8 g/day) increased defecations by ~1/week (statistically significant).
- Effect of fiber supplements on internal bleeding hemorrhoids
PubMed ID: 8975955
Psyllium resulted in clinical improvements related to stool passage and hemorrhoidal bleeding, consistent with constipation relief.
- [Use of glucomannan dietary fiber in changes in intestinal habit]
PubMed ID: 8566676
Randomized double‑blind crossover trial showed dose‑dependent, clinically significant increases in bowel movements with glucomannan.
- Reduction in diarrhea incidence by soluble fiber in patients receiving total or supplemental enteral nutrition
PubMed ID: 7602722
Adding soluble fiber reduced diarrhea events (improved predictable bowel function) in enteral‑fed patients (helps stabilize bowel patterns).
- Effect of dietary fiber (soy polysaccharide) on the severity, duration, and nutritional outcome of acute, watery diarrhea in children
PubMed ID: 8393174
Marked shortening of watery-stool duration in infants implies fewer/shorter diarrhoeal bathroom episodes and faster recovery.
- Encopresis: a study of treatment alternatives and historical and behavioral characteristics
PubMed ID: 8233146
High-fiber diet was part of an encopresis program producing sustained improvements in bowel habits among completers.
- A comparison of Agiolax and lactulose in elderly patients with chronic constipation
PubMed ID: 8234437
Agiolax (fibre + senna) outperformed lactulose for constipation endpoints (frequency, consistency, ease of evacuation) in elderly patients—direct high relevance.
- Chronic constipation in long stay elderly patients: a comparison of lactulose and a senna-fibre combination
PubMed ID: 8219947
Senna-plus-fibre increased stool frequency and ease of evacuation compared with lactulose—clear anti-constipation effect.
- Sex differences in colonic function: a randomised trial
PubMed ID: 8387940
Fiber intake produced faster mean transit time and greater stool weight — strong objective support for improved regularity.
- Efficacy of rifaximin on symptoms of uncomplicated diverticular disease of the colon. A pilot multicentre open trial. Diverticular Disease Study Group
PubMed ID: 1330083
Glucomannan improved clinical symptoms in diverticular disease; glucomannan is known to relieve constipation.
- Effects of cereal and vegetable fiber feeding on potential risk factors for colon cancer
PubMed ID: 1339081
Fibre increased stool weight and sped transit—direct evidence that certain fibres reduce constipation risk.
- The value of prescribed 'high-fibre' diets for the treatment of the irritable bowel syndrome
PubMed ID: 1667298
Large outpatient IBS sample showed higher fiber intake associated with reduced constipation/hard stools—direct evidence for reducing constipation.
- A comparison of mebeverine with high-fibre dietary advice and mebeverine plus ispaghula in the treatment of irritable bowel syndrome: an open, prospectively randomised, parallel group study
PubMed ID: 2177997
High‑fibre advice/ispaghula improved bowel frequency and stool consistency in IBS patients.
- The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiber
PubMed ID: 20191257
Direct RCT evidence: oat-bran fiber reduced laxative use by 59%—strong evidence for reducing constipation.
- Effectiveness of Partially Hydrolyzed Guar Gum in Reducing Constipation in Long Term Care Facility Residents: A Randomized Single-Blinded Placebo-Controlled Trial
PubMed ID: 35297467
PHGG reduced laxative dependence, implying easier, less urgent bathroom trips.
- Combinations of laxatives and green banana biomass on the treatment of functional constipation in children and adolescents: a randomized study
PubMed ID: 29309737
Randomized trial: green banana softened stools, reduced straining and decreased laxative needs.
- Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids: randomized controlled trial
PubMed ID: 10813126
Ispaghula husk shown clinically to assist with bowel movements in hemorrhoid patients.
- Effects of Resistant Glucan Mixture on Bowel Movement in Female Volunteers
PubMed ID: 27117853
Resistant glucan at 13.2 g/day significantly increased stool frequency/volume in constipated women (RCT) — direct evidence.
- [Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study]
PubMed ID: 29378102
Stool frequency increased substantially with the inulin-containing jelly in IBS-C participants.
- Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial
PubMed ID: 27492975
Inulin increased stool frequency and softened stools in people with chronic constipation — direct, clinically meaningful effect.
- Safety of a thickened extensive casein hydrolysate formula
PubMed ID: 26704966
Thickened formula improved stool consistency in infants, consistent with better regularity in that group.
- [Effect of ear mushroom (Auricularia) on functional constipation]
PubMed ID: 15266131
Direct RCT evidence: high-fiber ear-mushroom significantly increased bowel-movement frequency and relieved constipation-related symptoms in chronically constipated adults.
- Nutritional quality of calorie restricted diets in the CALERIE™ 1 trial
PubMed ID: 35643360
Demonstrated increase in fiber intake during the trial supports potential reduction in constipation risk, though constipation was not directly measured.
- A Symbiotic Meal Containing Extruded Sorghum and Probiotic (Bifidobacterium longum) Ameliorated Intestinal Health Markers in Individuals with Chronic Kidney Disease: A Secondary Analysis of a Subsample from a Previous Randomized and Controlled Clinical Trial
PubMed ID: 38931207
Symbiotic meal increased stool frequency and improved bowel habits in dialysis patients (direct evidence of improved regularity).
- Continuous partially hydrolyzed guar gum intake reduces cold-like symptoms: a randomized, placebo-controlled, double-blinded trial in healthy adults
PubMed ID: 35916813
Partially hydrolyzed guar gum raised stool SCFAs and reduced symptom days; fibre types like PHGG commonly improve stool frequency/regularity.
- The impact of almonds and almond processing on gastrointestinal physiology, luminal microbiology, and gastrointestinal symptoms: a randomized controlled trial and mastication study
PubMed ID: 36130222
Small increase in bowel movement frequency suggests easier/faster bathroom trips for some participants.
- Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults
PubMed ID: 28179226
Whole‑grain intake modestly improved stool SCFAs and microbiota, consistent with easier bowel movements.
- Lupin kernel fibre foods improve bowel function and beneficially modify some putative faecal risk factors for colon cancer in men
PubMed ID: 16469156
Increased defecation frequency and fecal output indicate easier, more predictable bathroom trips.
- The effect of wheat bran particle size on laxation and colonic fermentation
PubMed ID: 12038477
Finely ground wheat bran increased fecal bulk and fermentation markers—supports regularity.
- Pilot study of the feasibility and effectiveness of a natural laxative mixture
PubMed ID: 17430744
Laxative mixture significantly increased bowel movements and improved consistency in care-home residents (reduced constipation).
- Effects of legume kernel fibres and citrus fibre on putative risk factors for colorectal cancer: a randomised, double-blind, crossover human intervention trial
PubMed ID: 24060277
Fibers (lupin, legume, citrus) increased fecal weight and improved transit — supports regularity.
- The effects of waxy barley on defecation, sleep, mental health, and quality of life: a randomized double-blind parallel-group comparison study
PubMed ID: 40336123
High‑β‑glucan barley produced increased defecation frequency and stool amount—direct evidence reducing constipation risk in young women.
- Effect of arabinogalactan on the gut microbiome: A randomized, double-blind, placebo-controlled, crossover trial in healthy adults
PubMed ID: 34004416
Crossover study showed microbiome shifts with arabinogalactan that are consistent with promoting regular bowel habits.
- The Impact of Glucomannan, Inulin, and Psyllium Supplementation (Soloways(TM)) on Weight Loss in Adults with FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 38398881
Fiber blend likely improved stool frequency/consistency and thus ease of bathroom trips.
- Use of Insoluble Dietary Fiber and Probiotics for Bowel Preparation Before Colonoscopy: A Prospective Study
PubMed ID: 35202009
Preloading with wheat bran + probiotic markedly lowered required PEG volume and produced 100% adequate cleansing — makes the toileting/prep process easier.
- Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial
PubMed ID: 35971232
Prune juice RCT produced clear, clinically meaningful improvements in constipation symptoms and stool form.
- Efficacy of a multifactorial strategy for bowel preparation in diabetic patients undergoing colonoscopy: a randomized trial
PubMed ID: 27490086
In diabetics, a prep strategy including a low‑fibre diet markedly reduced inadequate bowel cleansing (direct evidence linking fiber restriction to bowel prep outcomes).
- One-day versus two-day cleansing for colon capsule endoscopy: a prospective randomized pilot study
PubMed ID: 24388792
One‑day fibre‑free PEG bowel prep gave comparable colon cleanliness to a two‑day schedule (direct evidence that short fibre restriction aids bowel prep).
- Bowel cleansing before CT colonography: comparison between two minimal-preparation regimens
PubMed ID: 25149295
Two reduced bowel‑prep regimens (one low‑fibre) provided comparable cleansing and tolerability—evidence relevant to practical bowel outcomes.
- Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome
PubMed ID: 19909743
Bran increased small‑bowel water content after meals, a physiologic effect that can help soften stools and relieve constipation.
- Small volume isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in treatment of chronic nonorganic constipation
PubMed ID: 8769292
Trial showed increased bowel frequency and easier defecation in chronic constipation—direct anti-constipation effect (but drug, not fiber).
- Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
PubMed ID: 35300378
Konjac glucomannan (fermentable soluble fiber) is strongly evidenced to relieve constipation and improve stool consistency/frequency.
- Gut Permeability Might be Improved by Dietary Fiber in Individuals with Nonalcoholic Fatty Liver Disease (NAFLD) Undergoing Weight Reduction
PubMed ID: 30453660
Higher‑fiber diet improved gut permeability and liver/GI markers—consistent with reduced constipation risk.
- Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial
PubMed ID: 38653808
Large RCT in IBS‑C: acacia fiber raised stool frequency by ≈1.3 stools/week vs placebo (clinically meaningful).
- A randomized, prospective, comparison study of a mixture of acacia fiber, psyllium fiber, and fructose vs polyethylene glycol 3350 with electrolytes for the treatment of chronic functional constipation in childhood
PubMed ID: 22677568
Fiber mix improved constipation in children with chronic functional constipation at 8 weeks (response ≈78%).
- Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients
PubMed ID: 17308252
Synbiotic + fermentable fibers improved intestinal function in critically ill patients, consistent with more regular gut function in that population.
- A hypocaloric diet rich in high fiber rye foods causes greater reduction in body weight and body fat than a diet rich in refined wheat: A parallel randomized controlled trial in adults with overweight and obesity (the RyeWeight study)
PubMed ID: 34620312
High‑fiber rye in a diet produced beneficial body/composition and inflammation changes; increased cereal fiber usually supports regularity though not directly measured here.
- Intake of okara soup for 2 weeks for breakfast improved defecation habits in young Japanese women with self-reported constipation: A randomized, double-blind, placebo-controlled, intervention study
PubMed ID: 32885419
Okara breakfast reduced constipation symptoms on a validated scale in young women.
- Soluble Dietary Fiber Reduces Feeding Intolerance in Severe Acute Pancreatitis: A Randomized Study
PubMed ID: 32141126
In severe acute pancreatitis, adding soluble fiber dramatically lowered constipation incidence (from 72.7% to 12.5%).
- Effects of rice-based and wheat-based diets on bowel movements in young Korean women with functional constipation
PubMed ID: 32322048
Higher-fiber brown-rice or wheat diets increased stool frequency and shortened transit time in women with functional constipation.
- Nopal fiber (Opuntia ficus-indica) improves symptoms in irritable bowel syndrome in the short term: a randomized controlled trial
PubMed ID: 32935904
Nopal fiber improved IBS symptoms and changed stool consistency (dose-dependent), consistent with effects on bowel regularity.
- Daily intake of wheat germ-enriched bread may promote a healthy gut bacterial microbiota: a randomised controlled trial
PubMed ID: 31325040
Wheat germ increased beneficial bacteria and reduced GI worries; supports better bowel habits and regularity.
- The effect of 'Zesy002' kiwifruit (Actinidia chinensis var. chinensis) on gut health function: a randomised cross-over clinical trial
PubMed ID: 31080591
Kiwifruit produced large, clinically significant increases in CSBMs and softer stools in mildly constipated adults.
- Efficacy of Polydextrose Supplementation on Colonic Transit Time, Bowel Movements, and Gastrointestinal Symptoms in Adults: A Double-Blind, Randomized, Placebo-Controlled Trial
PubMed ID: 30791557
Polydextrose (esp. 12 g/day) increased weekly bowel-movement frequency significantly vs placebo in an RCT.
- Effect of High Fiber Cereal Intake on Satiety and Gastrointestinal Symptoms during Ramadan
PubMed ID: 31027300
High-fiber breakfast increased reported bowel movements and improved bowel frequency over 20 days.
- Efficacy and safety of Gelidium elegans intake on bowel symptoms in obese adults: A 12-week randomized double-blind placebo-controlled trial
PubMed ID: 31027051
Gelidium elegans reduced stool symptom scores (PAC‑SYM) and abdominal discomfort vs placebo in obese adults.
- Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial
PubMed ID: 31509971
PHGG produced clinically meaningful normalization of stool consistency over weeks—strong evidence for improved regularity.
- Impact of Agaricus bisporus Mushroom Consumption on Gut Health Markers in Healthy Adults
PubMed ID: 30279332
Mushroom feeding increased stool weight (laxation) in healthy adults—supports more regular bowel movements.
- A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects
PubMed ID: 30541093
Whole‑grain wheat preserved microbiota diversity—supports functions tied to bowel regularity.
- The effect of prunes on stool output, gut transit time and gastrointestinal microbiota: A randomised controlled trial
PubMed ID: 29398337
Prune consumption significantly increased stool weight and weekly bowel-movement frequency in adults with low fiber intake.
- Could resistant starch supplementation improve inflammatory and oxidative stress biomarkers and uremic toxins levels in hemodialysis patients? A pilot randomized controlled trial
PubMed ID: 30468238
Resistant starch (a fermentable fiber) had beneficial biochemical effects in hemodialysis patients and is known to support regularity.
- Impact of Diets Rich in Whole Grains and Fruits and Vegetables on Cardiovascular Risk Factors in Overweight and Obese Women: A Randomized Clinical Feeding Trial
PubMed ID: 29702040
Whole-grain–rich diet in overweight/obese women improved multiple parameters; whole grains commonly aid stool regularity though not the primary outcome here.
- In healthy adults, resistant maltodextrin produces a greater change in fecal bifidobacteria counts and increases stool wet weight: a double-blind, randomized, controlled crossover study
PubMed ID: 30527258
25 g resistant maltodextrin increased stool wet weight and promoted bowel changes
- Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study
PubMed ID: 28705786
Synbiotic produced clinically meaningful improvements in constipation symptoms and stool frequency (pediatric RCT).
- Effect of Fibre Supplementation on Body Weight and Composition, Frequency of Eating and Dietary Choice in Overweight Individuals
PubMed ID: 28212353
Viscous fiber (PGX) trial showed physiologic changes (weight/waist/eating frequency) consistent with regular intake routines; direct stool-frequency outcomes not reported.
- [The efficacy and safety of testa triticum tricum purif in treatment of functional constipation in the late middle-aged and elderly patients: a multicenter randomized controlled clinical trial]
PubMed ID: 28789490
Wheat fiber robustly increased spontaneous bowel movement frequency and normalized stool form in constipation.
- Starch-entrapped microsphere fibers improve bowel habit but do not exhibit prebiotic capacity in those with unsatisfactory bowel habits: a phase I, randomized, double-blind, controlled human trial
PubMed ID: 28821315
Both psyllium and a slowly fermented fiber significantly increased weekly bowel movements.
- Substituting whole grains for refined grains in a 6-wk randomized trial favorably affects energy-balance metrics in healthy men and postmenopausal women
PubMed ID: 28179223
Whole‑grain (high‑fiber) substitution increased stool weight/output, supporting more regular bowel movements.
- Oligofructose Provides Laxation for Irregularity Associated with Low Fiber Intake
PubMed ID: 29258261
Oligofructose (15 g/day) increased bowel‑movement frequency in adults with low‑fiber diets — strong evidence for improved regularity.
- Effects of fiber and probiotics on diarrhea associated with enteral nutrition in gastric cancer patients: A prospective randomized and controlled trial
PubMed ID: 29069041
Fiber in enteral nutrition reduced diarrheal episodes and improved intestinal recovery; supports normalized bowel function in this clinical setting.
- A comparative study of transcutaneous interferential electrical stimulation plus behavioral therapy and behavioral therapy alone on constipation in postoperative Hirschsprung disease children
PubMed ID: 27524737
High‑fiber diet as part of therapy for constipated children associated with higher improvement rates; fiber was part of combined treatment.
- A randomised, double-blind, placebo-controlled clinical study: the effects of a synbiotic, Lepicol, in adults with chronic, functional constipation
PubMed ID: 27776217
Synbiotic (psyllium/inulin/probiotic) reduced laxative use and improved constipation QoL — direct evidence for reduced constipation.
- Randomised clinical trial: mixed soluble/insoluble fibre vs. psyllium for chronic constipation
PubMed ID: 27125883
Plum mixed fiber and psyllium substantially increased CSBMs and improved stool form and straining—strong evidence for easier, more comfortable bathroom trips.
- Probiotics and prebiotic fiber for constipation associated with Parkinson disease: An RCT
PubMed ID: 27543643
Probiotic + prebiotic fiber increased complete bowel movements/week and responder rates in constipated Parkinson's patients—clear improvement in ease/number of bathroom trips (component‑confounded).
- Psyllium Fiber Reduces Abdominal Pain in Children With Irritable Bowel Syndrome in a Randomized, Double-Blind Trial
PubMed ID: 27080737
Psyllium reduced constipated stools in children with IBS and lowered abdominal pain episode frequency—good evidence for reducing constipation in that population.
- Randomized, double-blind, placebo-controlled trial of Ficus carica paste for the management of functional constipation
PubMed ID: 27440682
Direct RCT evidence: fig paste improved colon transit and constipation symptoms vs placebo.
- Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial)
PubMed ID: 27733151
Psyllium is a soluble fiber commonly improving stool passage; trial showed weight/glycaemic benefits (laxation plausible though not primary outcome here).
- [Efficacy of pectin in the treatment of diarrhea predominant irritable bowel syndrome]
PubMed ID: 25809332
Pectin normalized stool form/frequency in IBS‑D, implying improved regularity for patients with abnormal stools.
- Safety, growth, and support to healthy gut microbiota by an infant formula enriched with functional compounds
PubMed ID: 26718667
Prebiotic GOS increased bifidobacteria in infants; such changes commonly associate with improved stool frequency/regularity.
- Effect of Polydextrose Intake on Constipation in Japanese Dialysis Patients: A Triple-Blind, Randomized, Controlled Trial
PubMed ID: 26440643
Polydextrose produced a large increase in stool frequency and improved bowel consistency—direct anti‑constipation effect.
- Psyllium fiber vs. placebo in early treatment after STARR for obstructed defecation: a randomized double-blind clinical trial
PubMed ID: 26325116
Psyllium after STARR produced large, clinically meaningful reductions in constipation scores vs placebo.
- Digestion-resistant maltodextrin effects on colonic transit time and stool weight: a randomized controlled clinical study
PubMed ID: 26437831
Resistant maltodextrin significantly shortened colonic transit time and increased stool volume/softness — strong evidence for improved regularity.
- Loperamide Versus Psyllium Fiber for Treatment of Fecal Incontinence: The Fecal Incontinence Prescription (Rx) Management (FIRM) Randomized Clinical Trial
PubMed ID: 26347971
Psyllium caused substantially less constipation than loperamide while treating fecal incontinence.
- Effect of inulin and fructo-oligosaccharide on the prevention of acute radiation enteritis in patients with gynecological cancer and impact on quality-of-life: a randomized, double-blind, placebo-controlled trial
PubMed ID: 26603881
Improved stool consistency and bowel movement profile during radiotherapy suggests more manageable bathroom trips.
- [Clinical benefits after soluble dietary fiber supplementation: a randomized clinical trial in adults with slow-transit constipation]
PubMed ID: 25623312
RCT in slow-transit constipation patients showed marked transit acceleration and symptom improvement with pectin.
- A multi-centre, randomised trial to assess whether increased dietary fibre intake (using a fibre supplement or high-fibre foods) produces healthy bowel performance and reduces laxative requirement in free living patients on peritoneal dialysis
PubMed ID: 24650128
Fiber supplementation improved bowel function and lowered laxative needs in peritoneal dialysis patients.
- Effects of dietary fiber with Bacillus coagulans lilac-01 on bowel movement and fecal properties of healthy volunteers with a tendency for constipation
PubMed ID: 25338680
Significant improvements in stool frequency and incomplete evacuation in functionally constipated subgroup after okara+probiotic product.
- Dietary fiber mixture in pediatric patients with controlled chronic constipation
PubMed ID: 24157445
Pediatric RCT: fiber mixture increased daily bowel movement frequency and nonhardened stools (direct evidence for regularity).
- Dietary fiber supplementation for fecal incontinence: a randomized clinical trial
PubMed ID: 25155992
Psyllium approximately halved fecal incontinence episodes and severity—clear functional improvement for toilet-related outcomes.
- Partially hydrolyzed guar gum in pediatric functional abdominal pain
PubMed ID: 23345946
PHGG normalized stools in a substantial proportion of pediatric IBS patients, indicating improved regularity.
- Effect of microbiological and immunological enteral nutrition on intestinal function and immune status in the patients with long-term use of antibiotics
PubMed ID: 24089227
Combined enteral formula including fiber reduced abdominal symptoms and improved tolerance—consistent with less constipation in that context.
- Polydextrose and soluble corn fiber increase five-day fecal wet weight in healthy men and women
PubMed ID: 23427334
20 g/day polydextrose or soluble corn fiber increased fecal bulk, stool frequency and softened stool—strong evidence for improved regularity.
- One year intermittent rifaximin plus fibre supplementation vs. fibre supplementation alone to prevent diverticulitis recurrence: a proof-of-concept study
PubMed ID: 23092785
Fibre used as baseline maintenance in diverticulitis care and part of management aimed at maintaining bowel function; direct effect of fibre alone not tested.
- The effect of a sweet potato, footbath, and acupressure intervention in preventing constipation in hospitalized patients with acute coronary syndromes
PubMed ID: 22847287
Trial reported a lower incidence of constipation in the group receiving sweet potato (high‑fibre food) as part of the intervention versus usual care.
- Personalized diet management can optimize compliance to a high-fiber, high-water diet in children with refractory functional constipation
PubMed ID: 22709778
Study in constipated children where personalized diet management increased fiber and water intake vs standard advice—directly relevant to reducing constipation though outcomes were compliance-focused.
- Randomised, double-blind and placebo-controlled study of the effect of a synbiotic dairy product on orocecal transit time in healthy adult women
PubMed ID: 23165580
Synbiotic product (contains fiber) significantly reduced transit time in functional constipation subgroup, consistent with reduced constipation.
- Bowel function after minimally invasive urogynecologic surgery: a prospective randomized controlled trial
PubMed ID: 22453316
Study endpoint was time to first bowel movement; the fiber-containing regimen shortened that time, directly supporting easier bathroom trips post-op.
- Effect of a mixture of inulin and fructo-oligosaccharide on Lactobacillus and Bifidobacterium intestinal microbiota of patients receiving radiotherapy: a randomised, double-blind, placebo-controlled trial
PubMed ID: 23588438
Prebiotic accelerated recovery of key gut microbes; microbiota improvements often support bowel regularity though regularity was not directly measured.
- [Influence of fiberform on defecation condition after surgery for benign anorectal lesion]
PubMed ID: 22205452
Trial showed large improvements in defecation smoothness, pain and interval—directly translates to easier bathroom trips.
- Randomised clinical trial: dried plums (prunes) vs. psyllium for constipation
PubMed ID: 21323688
Dried plums outperformed psyllium for increasing bowel movements and improving stool consistency in chronic constipation—strong evidence for relieving constipation.
- Does a self-management program change dietary intake in adults with irritable bowel syndrome?
PubMed ID: 21455043
IBS self-management raised fiber intake and supported sustained dietary changes likely improving bowel regularity.
- Animated biofeedback: an ideal treatment for children with dysfunctional elimination syndrome
PubMed ID: 22019033
In children, a program including high-fiber diet contributed to resolution of constipation in many participants though fiber-specific impact was confounded by multi-component treatment.
- Usefulness of psyllium in rehabilitation of obstructed defecation
PubMed ID: 21779973
Psyllium improved outcomes during rehab for obstructed defecation, including stool form and bowel frequency—direct constipation benefit.
- Coarse, but not finely ground, dietary fibre increases intestinal Firmicutes:Bacteroidetes ratio and reduces diarrhoea induced by experimental infection in piglets
PubMed ID: 22018207
Coarse wheat bran reduced diarrhoea and modified microbiota/SCFA in piglets; supports regularity effects (animal evidence).
- Linking long-term dietary patterns with gut microbial enterotypes
PubMed ID: 21885731
Human data show high‑fiber diets associate with decreased transit time and enterotype shifts—strong support for improved stool regularity.
- Can partially hydrolyzed guar gum be an alternative to lactulose in treatment of childhood constipation?
PubMed ID: 21331988
PHGG increased bowel frequency, improved stool consistency and reduced pain in constipated children — strong evidence for reducing constipation.
- NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
PubMed ID: 21164548
NUTRIOSE likely improves stool form and frequency over weeks, making bathroom trips easier.
- [Efficacy of using inulin fortified fermented milk products in patients with functional constipation]
PubMed ID: 19663305
Direct clinical evidence: inulin-fortified fermented milk improved constipation symptoms and QoL in patients with constipation.
- Effect of computer-based gaming on constipation management in children: A randomized controlled trial
PubMed ID: 41265369
Clear trial effect: increased fibre/fluid intake improved constipation outcomes in children.
- Comparison of Low-Gluten Diets Rich in Oats or Rice-A 6-Week Randomized Clinical Trial With Metabolically Challenged Volunteers
PubMed ID: 40331457
Oat‑based diet increased bowel movements/day compared with rice—supports improved regularity.
- Tolerance of high fibre supplementation among participants in a randomised trial to reduce cancer risk among Alaska Native peoples: Alaska FIRST
PubMed ID: 40999949
Resistant starch impacted bowel symptoms (fewer diarrhea reports) and is commonly associated with stool‑pattern changes/regularity.
- Mitigating digestive complications and neutropenia in pediatric leukemia through a Persian medicine product of whole wheat-based dietary intervention: a randomized triple-blind placebo-controlled trial
PubMed ID: 39847133
Wheat‑bran product produced clear reductions in constipation scores in chemotherapy patients.
- Fiber, lactose and fat-modified diet for the prevention of gastrointestinal chemo-radiotherapy-induced toxicity in patients with cervical cancer: Randomized clinical trial
PubMed ID: 39848009
Large RCT found the fiber‑adjusted diet nearly halved risk of mild constipation during treatment; direct evidence.
- Baseline intestinal microbiota composition influences response to a real-world dietary fiber intervention
PubMed ID: 41198696
Resistant starch/inulin improved bowel symptom scores in responsive individuals, consistent with better regularity.
- Comprehensive modulatory effects of whole grain consumption on immune-mediated inflammation in middle-aged and elderly community residents: A real-world randomized controlled trial
PubMed ID: 39260062
Whole‑grain replacement increased fecal butyrate and modulated immune markers—changes in fermentation/SCFA often support regular bowel habits.
- Effects of dietary fiber on maternal health in pregnant women with metabolic syndrome risk: a randomized controlled trial
PubMed ID: 38809131
Longer soluble‑fiber supplementation in pregnancy reduced need for constipation medication, indicating reduced constipation.
- Impact of resistant starch type 3 on fecal microbiota and stool frequency in Thai adults with chronic constipation randomized clinical trial
PubMed ID: 39543201
Resistant starch RCT produced large, clinically meaningful increases in stool frequency and normalization toward ≥4 BMs/week.
- The ALINFA Intervention Improves Diet Quality and Nutritional Status in Children 6 to 12 Years Old
PubMed ID: 37242258
Child nutrition intervention increased fiber intake and was associated with favorable anthropometric shifts; increased fiber reduces constipation risk.
- Agave tequilana Fructans Versus Psyllium plantago for Functional Constipation : Randomized Double-blind Clinical Trial
PubMed ID: 37389917
Agave fructans matched psyllium in improving CSBMs and constipation symptoms in a randomized trial.
- The Effects of Agave Fructans in a Functional Food Consumed by Patients with Irritable Bowel Syndrome with Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 37630717
Randomized placebo‑controlled trial in IBS‑C showed strong, rapid, clinically meaningful improvements in constipation frequency and stool form with agave fructans.
- Laser acupuncture improving functional chronic constipation in children: a randomized controlled trial
PubMed ID: 36790507
Pediatric trial where fiber/dietary advice formed effective treatment and improved stool frequency and form.
- Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial
PubMed ID: 37078654
Large RCT in functional constipation demonstrated clinically meaningful increases in stool frequency and softer stools with fiber formulas.
- Use of Faecal Transplantation with a Novel Diet for Mild to Moderate Active Ulcerative Colitis: The CRAFT UC Randomised Controlled Trial
PubMed ID: 34514495
UCED improved GI remission in UC, which can include reduced constipation/altered bowel habit.
- Two Gold Kiwifruit Daily for Effective Treatment of Constipation in Adults-A Randomized Clinical Trial
PubMed ID: 36235798
Kiwifruit produced clinically meaningful reductions in constipation scores and increased CSBM—direct evidence.
- [Efficacy of newly developed kombucha-based specialized food product for treatment of constipation-predominant irritable bowel syndrome]
PubMed ID: 36394933
Inulin‑enriched kombucha specifically improved bowel movement frequency and stool form in constipation‑predominant IBS—direct effect against constipation.
- Flaxseed Mucilage (IQP-LU-104) Reduces Body Weight in Overweight and Moderately Obese Individuals in a 12-week, Three-Arm, Double-Blind, Randomized, and Placebo-Controlled Clinical Study
PubMed ID: 35130547
Flaxseed mucilage is a viscous fiber; RCT showed strong clinical effects and such fibers commonly relieve constipation/improve stool frequency.
- Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial
PubMed ID: 34226572
Human RCT with rhamnan sulphate showed a clear increase in defecation frequency in participants with constipation tendency — strong evidence for improved regularity.
- The effects of abdominal "I LOV U" massage along with lifestyle training on constipation and distension in the elderly with stroke
PubMed ID: 33465382
Massage + lifestyle reduced constipation assessment scores and increased bowel movements in elderly stroke patients — relevant to constipation relief (not a fiber trial).
- Prevalence of constipation in adults with obesity class II and III and associated factors
PubMed ID: 33980157
Observed that non‑consumption of whole grains (low fiber) was associated with higher constipation prevalence in people with severe obesity — strong real‑world association.
- Effects of ID-HWS1000 on the Perception of Bowel Activity and Microbiome in Subjects with Functional Constipation: A Randomized, Double-Blind Placebo-Controlled Study
PubMed ID: 34406877
Synbiotic containing fibre improved functional constipation symptoms vs placebo.
- The effect of dietary fiber (oat bran) supplement on blood pressure in patients with essential hypertension: A randomized controlled trial
PubMed ID: 34090773
Oat‑bran fiber supplementation (≈8.9 g/day) modified gut microbiota; oat fiber is classically used to relieve constipation, supporting moderate relevance.
Appetite suppression (133)
- An Anthocyanin-Rich Mixed-Berry Intervention May Improve Insulin Sensitivity in a Randomized Trial of Overweight and Obese Adults
PubMed ID: 31775396
Mixed‑berry consumption reduced postprandial insulin exposure under controlled feeding—can promote appetite control.
- The Impact of Glucomannan, Inulin, and Psyllium Supplementation (Soloways(TM)) on Weight Loss in Adults with FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 38398881
Well-powered RCT: glucomannan+inulin+psyllium increased satiety and substantially reduced weight vs placebo.
- Gene-diet interaction in response to defatted flaxseed flour supplementation on obesity-related traits in Chinese overweight and obese adults: A randomized controlled trial
PubMed ID: 36368262
Flaxseed-flour biscuits caused genotype-dependent weight/BMI reductions suggesting appetite/energy-intake effects in some genotypes.
- Metabolomic analysis of plasma metabolites that may mediate effects of rye bread on satiety and weight maintenance in postmenopausal women
PubMed ID: 21084654
High-fiber rye bread increased plasma metabolites implicated in satiety and weight maintenance in humans.
- The effect of chitosan supplementation on liver function, hepatic steatosis predictors, and metabolic indicators in adults with non-alcoholic fatty liver disease: a randomized, double-blinded, placebo-controlled, clinical trial
PubMed ID: 40025618
Chitosan (1.5 g/day) with calorie reduction produced modest weight loss and waist reduction — consistent with improved satiety/appetite control though appetite was not directly measured.
- Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
PubMed ID: 35300378
Konjac glucomannan reduced BMI/fat mass and increased fullness in trials—strong evidence that this fiber improves appetite control.
- A new dietary strategy for long-term treatment of the metabolic syndrome is compared with the American Heart Association (AHA) guidelines: the MEtabolic Syndrome REduction in NAvarra (RESMENA) project
PubMed ID: 23968597
RESMENA diet with higher fiber contributed to weight/waist improvements suggesting improved appetite control.
- Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects
PubMed ID: 33672963
Dose-dependent increases in subjective satiety (especially 40 g) in healthy adults indicate improved appetite control.
- The Effect of Gum Arabic (Acacia Senegal) on Cardiovascular Risk Factors and Gastrointestinal Symptoms in Adults at Risk of Metabolic Syndrome: A Randomized Clinical Trial
PubMed ID: 33435475
Gum arabic reduced energy/carbohydrate intake in metabolic‑risk adults (suggests appetite/intake reduction).
- Gastrointestinal microbiome modulator improves glucose tolerance in overweight and obese subjects: A randomized controlled pilot trial
PubMed ID: 26424589
Inulin + oat β‑glucan trial reduced desire to eat and prospective intake (randomized controlled pilot).
- Development and empirical evaluation of a dietary intervention programme for individuals with prediabetes based on the health action process approach: A randomised controlled trial
PubMed ID: 41421300
Behavioral program increased fibre‑rich food choices and improved BMI—supports sustained appetite/food‑intake control.
- Comparison of Low-Gluten Diets Rich in Oats or Rice-A 6-Week Randomized Clinical Trial With Metabolically Challenged Volunteers
PubMed ID: 40331457
Oat intervention increased fibre intake and improved bowel habits with small waist reduction—consistent with increased satiety/appetite control.
- Effects of brown rice bran on appetite and depression in metabolic syndrome: a secondary analysis of an open-label randomised controlled trial
PubMed ID: 41190469
Brown rice bran powder increased feelings of fullness and changed ghrelin in metabolic syndrome patients (RCT).
- Effects of combined prebiotic fiber supplementation and weight loss counseling in adults with metabolic dysfunction-associated steatotic liver disease: a randomized controlled trial
PubMed ID: 40172664
Oligofructose‑enriched inulin produced significant reductions in desire-to-eat and hunger vs placebo.
- A Randomized Trial of the Efficacy of Three Weight Loss Diet Interventions in Overweight/Obese with Polycystic Ovary Syndrome
PubMed ID: 38988067
High‑protein + high‑dietary‑fiber weight‑loss diet preserved lean mass and produced greater visceral fat loss — fiber likely contributed to appetite/energy balance improvement in the multi‑component diet.
- Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial
PubMed ID: 37793780
High‑dose inulin reduced reward‑area brain responses to high‑calorie foods and lowered subjective wanting—direct appetite regulation evidence.
- The ALINFA Intervention Improves Diet Quality and Nutritional Status in Children 6 to 12 Years Old
PubMed ID: 37242258
ALINFA child intervention increased fiber intake and produced favourable anthropometric changes, consistent with improved appetite/energy regulation.
- HIGH-FIBER DIET PROMOTES METABOLIC, HORMONAL, AND SATIETY EFFECTS IN OBESE WOMEN ON A SHORT-TERM CALORIC RESTRICTION
PubMed ID: 37556741
Short‑term high‑fiber calorie‑restricted diet in obese women increased satiety and suppressed postprandial ghrelin.
- Evidence that carbohydrate-to-fat ratio and taste, but not energy density or NOVA level of processing, are determinants of food liking and food reward
PubMed ID: 37980953
Experimental study: higher-fiber foods rated lower on liking/reward, suggesting fiber-rich foods may reduce food reward and help appetite control.
- Effects of Synbiotic Supplementation on Metabolic Syndrome Traits and Gut Microbial Profile among Overweight and Obese Hong Kong Chinese Individuals: A Randomized Trial
PubMed ID: 37836532
Fiber‑rich diet in weight‑loss trial (with synbiotic) produced larger weight loss consistent with improved appetite control.
- Short-Term Effect of Additional Daily Dietary Fibre Intake on Appetite, Satiety, Gastrointestinal Comfort, Acceptability, and Feasibility
PubMed ID: 36235865
Participants qualitatively reported greater fullness and reduced snacking after barley‑derived fiber despite no questionnaire change.
- Diverging metabolic effects of 2 energy-restricted diets differing in nutrient quality: a 12-week randomized controlled trial in subjects with abdominal obesity
PubMed ID: 35102369
Higher‑quality diet (more fiber) produced ~2 kg greater weight loss on energy restriction, consistent with better appetite control.
- The effects of probiotics plus dietary fiber on antipsychotic-induced weight gain: a randomized clinical trial
PubMed ID: 35508529
Probiotics+dietary‑fiber combo prevented antipsychotic‑associated weight gain, implying appetite/metabolic benefits (multi‑component).
- Flaxseed Mucilage (IQP-LU-104) Reduces Body Weight in Overweight and Moderately Obese Individuals in a 12-week, Three-Arm, Double-Blind, Randomized, and Placebo-Controlled Clinical Study
PubMed ID: 35130547
Flaxseed mucilage produced substantial weight/fat loss over 12 weeks, consistent with increased satiety/appetite suppression.
- Consuming a Protein and Fiber-Based Supplement Preload Promotes Weight Loss and Alters Metabolic Markers in Overweight Adults in a 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 35212740
Pre‑meal protein+fiber preload produced greater weight loss vs control, consistent with improved appetite control/satiety.
- Resistant starch wheat increases PYY and decreases GIP but has no effect on self-reported perceptions of satiety
PubMed ID: 34774669
Resistant starch raised circulating PYY (an appetite‑suppressing gut hormone) — physiological support for appetite control despite no subjective change in that study.
- Policaptil Gel Retard Intake Reduces Postprandial Triglycerides, Ghrelin and Appetite in Obese Children: A Clinical Trial
PubMed ID: 31947628
Premeal polysaccharide fiber (PGR) in obese children reduced ghrelin and subjective appetite (randomized trial).
- Effect of a functional fibre supplement on glycemic control when added to a year-long medically supervised weight management program in adults with type 2 diabetes
PubMed ID: 32642971
Viscous fiber (PGX) used in weight‑loss program produced sustained weight loss and likely satiety effects in a large RCT (moderate evidence).
- Dietary Fibres and the Management of Obesity and Metabolic Syndrome: The RESOLVE Study
PubMed ID: 32977595
In the RESOLVE program higher fiber intake was the nutritional variable most consistently predicting body composition and metabolic improvements, consistent with improved appetite control/satiety.
- A Coaching Program to Improve Dietary Intake of Patients with CKD: ENTICE-CKD
PubMed ID: 32111701
Dietitian telehealth increased fiber intake and was associated with weight loss (exploratory), consistent with improved appetite control.
- Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults: A Randomized Clinical Trial
PubMed ID: 33252690
Low-fat vegan (higher-fiber) diet produced substantial weight loss and metabolic improvements; increased fiber likely aided appetite regulation.
- Pretreatment Fasting Glucose and Insulin as Determinants of Weight Loss on Diets Varying in Macronutrients and Dietary Fibers-The POUNDS LOST Study
PubMed ID: 30861997
Higher dietary fiber intake during energy-restricted diets associated with substantially greater long-term weight loss — consistent with improved appetite/satiety contributing to adherence.
- Impact of oat processing on glycaemic and insulinaemic responses in healthy humans: a randomised clinical trial
PubMed ID: 31068229
Less-processed oats produced lower glucose/insulin responses; slower glycemia often associates with improved appetite control.
- Effect of High Fiber Cereal Intake on Satiety and Gastrointestinal Symptoms during Ramadan
PubMed ID: 31027300
High-fiber breakfast cereal produced large, clinically meaningful increases in short-term fullness in an RCT.
- Effect of an individualised high-protein, energy-restricted diet on anthropometric and cardio-metabolic parameters in overweight and obese Malaysian adults: a 6-month randomised controlled study
PubMed ID: 30761964
High‑protein, energy‑restricted diet that included higher fibre produced greater weight loss and improved metabolic markers, consistent with better appetite/energy regulation.
- A proof-of-concept study to evaluate the efficacy and safety of BTI320 on post-prandial hyperglycaemia in Chinese subjects with pre-diabetes
PubMed ID: 30170579
Chewable galactomannan reduced post‑meal glucose excursions and produced small weight loss, consistent with improved appetite/food intake regulation.
- A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
PubMed ID: 30425247
Postprandial PYY (satiety hormone) increased on the cereal‑fiber dietary change, indicating improved appetite control.
- A Plant-Based High-Carbohydrate, Low-Fat Diet in Overweight Individuals in a 16-Week Randomized Clinical Trial: The Role of Carbohydrates
PubMed ID: 30223451
High-fiber, plant-based diet produced weight and insulin-resistance improvements over 16 weeks, consistent with better appetite/energy regulation.
- Postprandial glucose-lowering effect of premeal consumption of protein-enriched, dietary fiber-fortified bar in individuals with type 2 diabetes mellitus or normal glucose tolerance
PubMed ID: 29502350
Premeal bar with 12.7 g fiber increased GLP‑1 and substantially reduced postprandial glucose/insulin — strong mechanistic evidence for improved appetite control and satiety.
- Impact of Diets Rich in Whole Grains and Fruits and Vegetables on Cardiovascular Risk Factors in Overweight and Obese Women: A Randomized Clinical Feeding Trial
PubMed ID: 29702040
Whole-grain (higher-fiber) weight-loss diet improved weight/waist—consistent with improved appetite control though appetite was not directly measured.
- Adolescents perceive a low added sugar adequate fiber diet to be more satiating and equally palatable compared to a high added sugar low fiber diet in a randomized-crossover design controlled feeding pilot trial
PubMed ID: 29751193
Higher-fiber diet in adolescents reduced hunger and increased fullness
- Type-4 Resistant Starch in Substitution for Available Carbohydrate Reduces Postprandial Glycemic Response and Hunger in Acute, Randomized, Double-Blind, Controlled Study
PubMed ID: 29373530
RS4 scone RCT produced large decreases in hunger/desire to eat (acute satiety)
- [Effect of quinua (Chenopodium quinoa)consumption as a coadjuvant in nutritional intervention in prediabetic subjects]
PubMed ID: 29130716
Processed quinoa trial reported increased feelings of fullness vs placebo over 28 days.
- Impact of Agaricus bisporus mushroom consumption on satiety and food intake
PubMed ID: 28647383
Replacing meat with higher-fiber mushrooms reduced hunger and prospective consumption (short trial, no intake change).
- The effect of soluble fiber dextrin on postprandial appetite and subsequent food intake in healthy adults
PubMed ID: 29429537
20 g soluble fiber dextrin reduced hunger/desire to eat and increased fullness subjectively (no intake change).
- Effect of Fibre Supplementation on Body Weight and Composition, Frequency of Eating and Dietary Choice in Overweight Individuals
PubMed ID: 28212353
Viscous fiber (PGX) trial showed fewer eating occasions and modest weight loss, indicating improved appetite control.
- Co-administration of a konjac-based fibre blend and American ginseng (Panax quinquefolius L.) on glycaemic control and serum lipids in type 2 diabetes: a randomized controlled, cross-over clinical trial
PubMed ID: 28687934
Konjac (viscous glucomannan) is associated with increased fullness and the study showed glycemic benefits in T2D.
- Prebiotic supplementation improves appetite control in children with overweight and obesity: a randomized controlled trial
PubMed ID: 28228425
Oligofructose/inulin in children increased fullness and reduced prospective food consumption and intake at test buffet.
- Glycemic Index of a Novel High-Fiber White Rice Variety Developed in India--A Randomized Control Trial Study
PubMed ID: 26741823
High‑fiber white rice had much lower GI and more resistant starch; lower glycemic exposure can promote satiety relative to standard white rice (physiologic plausibility + GI data).
- Acute effects of different dietary polysaccharides added in milk on food intake, postprandial appetite and glycemic responses in healthy young females
PubMed ID: 27352777
Acute RCT: guar gum and alginate reduced subjective appetite and reduced caloric intake at the next meal—strong direct evidence for short‑term appetite control.
- Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial)
PubMed ID: 27733151
Psyllium (10.5 g/d) produced meaningful weight loss over 8 weeks, consistent with appetite/energy intake effects.
- The effects of the combination of egg and fiber on appetite, glycemic response and food intake in normal weight adults - a randomized, controlled, crossover trial
PubMed ID: 27306734
A moderate‑protein + fiber breakfast reduced subsequent energy intake vs low‑protein cereal (acute effect).
- Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial
PubMed ID: 26811130
15 g/day pea fiber lowered voluntary energy intake (~−16% at follow‑up lunch) and reduced body fat/weight.
- Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial
PubMed ID: 27810310
Prebiotic+probiotic combination reduced energy intake and body fat/waist in overweight adults (dietary intake effect).
- Effects of oatmeal and corn flakes cereal breakfasts on satiety, gastric emptying, glucose, and appetite-related hormones
PubMed ID: 25612907
Oatmeal RCT (soluble fiber) markedly increased fullness and reduced subsequent lunch intake.
- Effects of two dietary fibers as part of ready-to-eat cereal (RTEC) breakfasts on perceived appetite and gut hormones in overweight women
PubMed ID: 25689743
Added cereal fibers increased GLP‑1 and PYY (satiety hormones) despite no acute change in perceived appetite—physiologic signal for appetite regulation.
- Weight Maintenance with Litramine (IQP-G-002AS): A 24-Week Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 26435849
Soluble-fibre complex (Litramine) increased reported satiety in a 24‑week RCT—supports appetite control.
- α-Galacto-oligosaccharides Dose-Dependently Reduce Appetite and Decrease Inflammation in Overweight Adults
PubMed ID: 26180243
α‑galacto‑oligosaccharides (prebiotic fiber) dose‑dependently increased satiety AUC and reduced meal energy intake in overweight adults.
- Satiety effects of a whole-grain fibre composite ingredient: reduced food intake and appetite ratings
PubMed ID: 25138661
Randomized human crossover trial: a viscous whole‑grain fibre ingredient reduced hunger ratings and lowered subsequent energy intake acutely.
- Effects of different amounts of konjac flour inclusion in gestation diets on physio-chemical properties of diets, postprandial satiety in pregnant sows, lactation feed intake of sows and piglet performance
PubMed ID: 25466211
Konjac (glucomannan) raised GLP‑1 and satiety markers in a large animal model → plausible appetite control.
- Effect of two dietary fibers on satiety and glycemic parameters: a randomized, double-blind, placebo-controlled, exploratory study
PubMed ID: 24886409
Oligofructose+pectin supplementation showed small reductions in postprandial glucose/insulin and trends to lower intake/fullness changes.
- The impact of soluble dietary fibre on gastric emptying, postprandial blood glucose and insulin in patients with type 2 diabetes
PubMed ID: 24901089
7.5 g oat β‑glucan slowed gastric emptying and lowered postprandial glucose/insulin in T2D — supports longer satiety and appetite control.
- An enriched, cereal-based bread affects appetite ratings and glycemic, insulinemic, and gastrointestinal hormone responses in healthy adults in a randomized, controlled trial
PubMed ID: 25644342
Fiber‑ and protein‑enriched cereal bread increased satiety AUC vs white bread (acute appetite control evidence).
- Effects of whole grain rye crisp bread for breakfast on appetite and energy intake in a subsequent meal: two randomised controlled trails with different amounts of test foods and breakfast energy content
PubMed ID: 24661836
Whole-grain rye breakfast reduced hunger/desire to eat and lowered subsequent energy intake vs refined wheat (appetite benefit).
- The effects of functional fiber on postprandial glycemia, energy intake, satiety, palatability and gastrointestinal wellbeing: a randomized crossover trial
PubMed ID: 25066659
Two functional fibers in bread reduced postprandial glucose spikes and reduced next-meal energy intake (appetite control evidence).
- Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
PubMed ID: 25500202
Direct evidence: colonic propionate delivery increased PYY/GLP‑1 and acutely reduced energy intake.
- Changes in visceral adiposity and serum cholesterol with a novel viscous polysaccharide in Japanese adults with abdominal obesity
PubMed ID: 23512917
Viscous fiber (PGX) can increase satiety in other studies and produced reductions in abdominal adiposity here, consistent with appetite effects.
- Daily consumption of a synbiotic yogurt decreases energy intake but does not improve gastrointestinal transit time: a double-blind, randomized, crossover study in healthy adults
PubMed ID: 23787118
Synbiotic yogurt with inulin was associated with lower energy intake vs control (suggesting improved appetite control).
- A natural fiber complex reduces body weight in the overweight and obese: a double-blind, randomized, placebo-controlled study
PubMed ID: 23505169
Standardized natural fiber complex produced greater weight loss—consistent with improved appetite control contributing to results.
- Satiety and energy intake after single and repeated exposure to gel-forming dietary fiber: post-ingestive effects
PubMed ID: 24030518
Single-dose gel-forming pectin reduced ad libitum energy intake (~5.6%), indicating improved acute appetite control.
- The effects of bulking, viscous and gel-forming dietary fibres on satiation
PubMed ID: 22850326
Gel-forming alginate in foods produced a large (22%) reduction in ad libitum energy intake and increased oral exposure time—direct satiation/appetite control effect.
- Flaxseed dietary fiber supplements for suppression of appetite and food intake
PubMed ID: 22245724
Small dose soluble flax fiber increased fullness and reduced next‑meal energy intake in randomized crossover trials.
- Low glycemic load experimental diet more satiating than high glycemic load diet
PubMed ID: 22564018
Low‑glycemic‑load diet (higher fiber) produced greater fullness and reduced cravings in a controlled feeding study.
- Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults
PubMed ID: 21414045
High-viscosity soluble fiber trial in overweight women increased fullness/reduced weight—direct evidence for improved appetite control.
- Rye kernel breakfast increases satiety in the afternoon - an effect of food structure
PubMed ID: 21481225
Whole-grain rye breakfasts (high fibre) increased satiety through the afternoon versus refined wheat—supports appetite control.
- Effects of NUTRIOSE® dietary fiber supplementation on body weight, body composition, energy intake, and hunger in overweight men
PubMed ID: 21591985
NUTRIOSE (soluble fiber) reduced hunger and energy intake and produced modest weight loss over 12 weeks—direct evidence for appetite control.
- The soluble fiber NUTRIOSE induces a dose-dependent beneficial impact on satiety over time in humans
PubMed ID: 22024490
Randomized trial of soluble fiber (NUTRIOSE) produced dose-dependent increases in satiety and reductions in hunger — strong direct evidence for appetite control.
- Comparison of high protein and high fiber weight-loss diets in women with risk factors for the metabolic syndrome: a randomized trial
PubMed ID: 21524314
High‑fiber diet arm raised fiber intake and contributed to weight/fat loss—consistent with improved satiety/appetite control.
- Effect of weight loss intervention on the association between eating behaviour measured by TFEQ-18 and dietary intake in adults
PubMed ID: 20955744
Observationally, higher fiber intake correlated with greater cognitive restraint and larger weight loss—suggests improved appetite control via behaviour/food choices.
- Short-term effects of a snack including dried prunes on energy intake and satiety in normal-weight individuals
PubMed ID: 20434071
Prune (fiber‑rich) snack increased subjective fullness and reduced subsequent dessert and total energy intake acutely.
- Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults
PubMed ID: 20664618
Daily PGX altered satiety hormone (PYY) profiles, especially in leaner subjects, supporting improved appetite regulation.
- Regular consumption of a cereal breakfast. Effects on mood and body image satisfaction in adult non-obese women
PubMed ID: 20832439
Randomized breakfast study: cereal (perceived higher-fibre) produced greater fullness and improved appetite/mood measures.
- NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
PubMed ID: 21164548
NUTRIOSE RCT reduced weight/body fat; effects likely mediated partly via improved appetite control though appetite not primary endpoint.
- Chickpea supplementation in an Australian diet affects food choice, satiety and bowel health
PubMed ID: 19945492
Chickpea supplementation increased perceived fullness and reduced intake of some foods over 12 weeks — supportive evidence for appetite/satiation effects.
- Viscosity of fiber preloads affects food intake in adolescents
PubMed ID: 19157816
High-viscosity fiber preload in adolescents reduced subsequent ad libitum meal intake by ~10–12%, indicating improved short-term appetite control.
- Effect of rye bread breakfasts on subjective hunger and satiety: a randomized controlled trial
PubMed ID: 19709412
Rye (high‑fiber) breakfasts produced consistent, significant increases in morning satiety and reduced hunger/desire to eat.
- A randomized behavioural trial targeting glycaemic index improves dietary, weight and metabolic outcomes in patients with type 2 diabetes
PubMed ID: 19161649
Program that increased fiber intake produced weight/BMI improvements consistent with improved appetite control/energy intake regulation.
- High intake of fruits and vegetables predicts weight loss in Brazilian overweight adults
PubMed ID: 19083413
Increase in fruit/vegetable-derived fiber during counseling predicted modest weight loss over 6 months, consistent with improved appetite control as a plausible mechanism.
- A low-energy-dense diet adding fruit reduces weight and energy intake in women
PubMed ID: 18439712
Adding apples or pears (low energy‑density, fiber‑rich) reduced energy intake and produced modest weight loss, consistent with improved appetite/satiety.
- Use of cereal fiber to facilitate adherence to a human caloric restriction program
PubMed ID: 19179834
High‑fiber cereal users showed greater dietary satisfaction and better adherence to caloric restriction in follow‑up, suggesting improved appetite control/behavior.
- Hydroxypropylmethylcellulose and methylcellulose consumption reduce postprandial insulinemia in overweight and obese men and women
PubMed ID: 18203894
Viscous modified-cellulose fibers reduced postprandial insulin and peak glucose—physiologic basis for improved appetite control.
- Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial
PubMed ID: 18031592
Soluble-fiber supplement in a calorie-restricted trial significantly increased postprandial satiety/fullness.
- Improvement of insulin resistance after diet with a whole-grain based dietary product: results of a randomized, controlled cross-over study in obese subjects with elevated fasting blood glucose
PubMed ID: 17562226
Whole‑grain (fiber‑rich) meal replacement improved fasting insulin/HOMA beyond weight loss which can be associated with better appetite regulation.
- The benefits of early intervention in obese diabetic patients with FBCx: a new dietary fibre
PubMed ID: 17013969
FBCx fiber product helped obese diabetic patients avoid weight gain versus placebo, consistent with appetite/energy intake effects (randomized trial).
- Food cravings and energy regulation: the characteristics of craved foods and their relationship with eating behaviors and weight change during 6 months of dietary energy restriction
PubMed ID: 17593902
Observational data show craved foods were lower in fiber, implying higher habitual fiber may support better appetite regulation.
- Health Hunters--an intervention to prevent overweight and obesity in young high-risk women
PubMed ID: 16276359
Behavioral prevention trial associated higher dietary fiber density with protection for weight outcomes, implying improved appetite/energy balance (associative evidence).
- Lupin-enriched bread increases satiety and reduces energy intake acutely
PubMed ID: 17093146
Lupin (high protein + fiber) bread reduced ghrelin and decreased subsequent energy intake in crossover trials.
- Effect of a viscous fiber-containing nutrition bar on satiety of patients with type 2 diabetes
PubMed ID: 17023088
Viscous fiber bar produced a sizable increase in subjective fullness in overweight/obese adults with T2D.
- Glucagon-like peptide-1 release and satiety after a nutrient challenge in normal-weight and obese subjects
PubMed ID: 16022753
Guar gum acutely increased GLP-1 and subjective satiety (strong physiological basis for appetite control).
- Experiences with three different fiber supplements in weight reduction
PubMed ID: 15614200
Viscous fiber supplements (glucomannan ±) produced significantly greater short-term weight loss consistent with improved satiety/appetite control.
- Effects of agar (kanten) diet on obese patients with impaired glucose tolerance and type 2 diabetes
PubMed ID: 15642074
Agar (a viscous fiber) led to greater weight loss vs diet alone, consistent with appetite/satiety effects.
- Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial
PubMed ID: 14744846
Ad libitum high-carb/high-fibre diet produced spontaneous weight loss, consistent with improved satiety/appetite control.},{
- Effects of a beverage containing an enzymatically induced-viscosity dietary fiber, with or without fructose, on the postprandial glycemic response to a high glycemic index food in humans
PubMed ID: 12947431
Guar gum (5 g) forms viscosity and lowers postprandial glucose excursions; viscous fibers are well-linked to increased satiety and appetite control (direct human evidence).
- The efficacy of cisapride vs. placebo and diet in patients with chronic constipation
PubMed ID: 12974147
High-fiber diet in constipated patients improved bowel function and likely contributed to improved satiety/appetite regulation in that intervention phase (clinical but indirect).
- Low glycemic index breakfasts and reduced food intake in preadolescent children
PubMed ID: 14595085
Low-GI breakfasts (often higher in fiber) reduced subsequent lunch energy intake in children — supports appetite control though fiber was not isolated.
- Ready-to-eat cereal used as a meal replacement promotes weight loss in humans
PubMed ID: 12480804
Ready-to-eat cereal as portion-controlled meal replacement reduced intake and produced short-term weight loss—supports appetite control (often high-fibre cereals).
- Long-term effect of fibre supplement and reduced energy intake on body weight and blood lipids in overweight subjects
PubMed ID: 11294130
Fibre supplement plus 1200 kcal diet gave greater weight loss — consistent with improved appetite control / satiety when combined with calorie restriction.
- Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance
PubMed ID: 10447232
High‑fiber diet was a component of an intensive program that produced substantial weight loss; suggests improved appetite control among mechanisms.
- [Evaluation of the action of glucomannan on metabolic parameters and on the sensation of satiation in overweight and obese patients]
PubMed ID: 7796558
Glucomannan added to a low‑calorie diet improved weight and glycaemic outcomes, consistent with appetite/energy-intake effects.
- [Chronic use of glucomannan in the dietary treatment of severe obesity]
PubMed ID: 1313163
Glucomannan added to a low-calorie diet improved diet adherence and fat loss, consistent with appetite/satiety effects.
- Efficacy of rifaximin on symptoms of uncomplicated diverticular disease of the colon. A pilot multicentre open trial. Diverticular Disease Study Group
PubMed ID: 1330083
Glucomannan (soluble fibre) is known to increase satiety and the trial showed symptomatic improvement likely tied to reduced intake.
- A dietary fibre supplement in the treatment of mild hypertension. A randomized, double-blind, placebo-controlled trial
PubMed ID: 1313484
Fibre supplement led to weight loss in an RCT, consistent with improved appetite control.
- Overweight treated with energy restriction and a dietary fibre supplement: a 6-month randomized, double-blind, placebo-controlled trial
PubMed ID: 2172178
7 g/day fibre supplement added to low‑calorie diet reduced hunger VAS and increased weight loss (randomized DB trial).
- Eating rate of commonly consumed foods promotes food and energy intake
PubMed ID: 21094194
Human study: foods higher in fibre were eaten more slowly and slower eating correlated with lower energy intake (indirect support for appetite control).
- Impact of some isoenergetic snacks on satiety and next meal intake in healthy adults
PubMed ID: 19743984
Acute human crossover: a fibre-enriched yogurt increased short-term fullness and was associated with lower next-meal energy intake.
- Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice
PubMed ID: 23207186
Inulin-based soluble fiber modestly lowered immediate calorie intake and reduced subjective hunger (short-term appetite control).
- The effects of chitosan supplementation on anthropometric indicators of obesity, lipid and glycemic profiles, and appetite-regulated hormones in adolescents with overweight or obesity: a randomized, double-blind clinical trial
PubMed ID: 36064382
Chitosan in adolescents changed appetite-related hormones (leptin/adiponectin) and reduced weight, suggesting appetite/metabolic effects.
- The efficacy of daily snack replacement with oligofructose-enriched granola bars in overweight and obese adults: a 12-week randomised controlled trial
PubMed ID: 29490721
Oligofructose bars reduced subjective hunger (P=0.04) though calorie intake/weight were unchanged — direct appetite signal.
- Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis
PubMed ID: 29777234
Shows people with certain microbiome profiles lose more weight on higher-fiber diets, consistent with appetite/energy-intake effects.
- Daily ingestion of alginate reduces energy intake in free-living subjects
PubMed ID: 18655817
Daily alginate preload reduced free‑living daily energy intake by ~7%, showing stronger appetite control in free‑living adults.
- The Effects of High Fiber Rye, Compared to Refined Wheat, on Gut Microbiota Composition, Plasma Short Chain Fatty Acids, and Implications for Weight Loss and Metabolic Risk Factors (the RyeWeight Study)
PubMed ID: 35458231
Hypocaloric high-fiber rye in weight-loss context produced metabolic/SCFA changes that plausibly help satiety and appetite control during caloric restriction.
- Effects of high-fiber diets enriched with carbohydrate, protein, or unsaturated fat on circulating short chain fatty acids: results from the OmniHeart randomized trial
PubMed ID: 31927581
High-fiber diets altered circulating SCFAs with links to lower insulin and glucose—plausible mechanism for improved appetite control.
- Modulation of amino acid metabolic signatures by supplemented isoenergetic diets differing in protein and cereal fiber content
PubMed ID: 25157543
Isoenergetic increases in cereal fiber altered amino-acid signatures linked to insulin resistance and metabolic state, consistent with appetite/satiety effects.
- Effect of Walnut Predinner Snack on Mealtime Hunger and Nutrient Intake Among University Students
PubMed ID: 34714144
Walnut snack (fiber-containing) increased premeal fullness and reduced subsequent meal calories.
- Added soluble fiber enhances the satiating power of low-energy-density liquid yogurts
PubMed ID: 19857627
6 g inulin increased fullness and reduced subsequent intake in a controlled trial.
- Metabolite Biomarkers Linking a High-Fiber Rye Intervention with Cardiometabolic Risk Factors: The RyeWeight Study
PubMed ID: 40838659
High‑fiber rye associated with greater weight/fat loss (likely via satiety/appetite effects) in a large RCT.
- Instant Oatmeal Increases Satiety and Reduces Energy Intake Compared to a Ready-to-Eat Oat-Based Breakfast Cereal: A Randomized Crossover Trial
PubMed ID: 26273900
Instant oatmeal (β‑glucan/viscosity) reduced hunger AUC and lowered next‑meal energy intake by ~85 kcal in a crossover trial.
- Enrichment of biscuits and juice with oat β-glucan enhances postprandial satiety
PubMed ID: 24434584
Oat bran–enriched foods increased postprandial satiety in a dose-/matrix‑dependent manner (up to 8 g).
- Acute effect of oatmeal on subjective measures of appetite and satiety compared to a ready-to-eat breakfast cereal: a randomized crossover trial
PubMed ID: 24024772
Oatmeal increased fullness and decreased hunger vs RTEC across the morning—robust acute satiety findings.
- Addition of Rye Bran and Pea Fiber to Pork Meatballs Enhances Subjective Satiety in Healthy Men, but Does Not Change Glycemic or Hormonal Responses: A Randomized Crossover Meal Test Study
PubMed ID: 28794212
Adding rye bran + pea fiber increased subjective satiety and reduced hunger/prospective intake in an acute crossover trial.
- Barley-Based Cereals Enhance Metabolic Health and Satiety in Overweight Korean Adults: A Randomized Trial
PubMed ID: 40944189
6‑week barley cereal reduced body fat/waist and improved short‑term glycemia—consistent with better appetite/energy balance.
- Effect of Barley on Postprandial Blood Glucose Response and Appetite in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39599684
Double‑blind crossover showed large reductions in hunger VAS and increased satiety after a barley dietary‑fiber drink.
- Using the Avocado to Test the Satiety Effects of a Fat-Fiber Combination in Place of Carbohydrate Energy in a Breakfast Meal in Overweight and Obese Men and Women: A Randomized Clinical Trial
PubMed ID: 31035472
Whole‑avocado breakfast markedly suppressed hunger and raised PYY; fiber likely contributed to appetite suppression.
Satiety (124)
- High hydrostatic pressure processing reduces the glycemic index of fresh mango puree in healthy subjects
PubMed ID: 25797308
Lower glycemic responses and delayed Tmax after a higher‑viscosity (fibre‑like) puree suggest more prolonged postprandial satiety potential.
- Metabolomic analysis of plasma metabolites that may mediate effects of rye bread on satiety and weight maintenance in postmenopausal women
PubMed ID: 21084654
High‑fiber rye bread intervention raised metabolites thought to mediate satiety and weight maintenance—strongest direct evidence here for longer fullness.
- The effect of chitosan supplementation on liver function, hepatic steatosis predictors, and metabolic indicators in adults with non-alcoholic fatty liver disease: a randomized, double-blinded, placebo-controlled, clinical trial
PubMed ID: 40025618
Chitosan supplementation plus calorie reduction yielded modest weight loss and waist reduction — consistent with increased fullness/satiety (though satiety not directly measured).
- Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
PubMed ID: 35300378
Konjac is viscous, slows gastric emptying and promotes satiety—trial showed substantial weight/fat loss consistent with increased fullness.
- A new dietary strategy for long-term treatment of the metabolic syndrome is compared with the American Heart Association (AHA) guidelines: the MEtabolic Syndrome REduction in NAvarra (RESMENA) project
PubMed ID: 23968597
Higher‑fiber RESMENA diet contributed to weight loss and likely increased satiety, though multiple diet changes limit attribution.
- Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects
PubMed ID: 33672963
Acacia gum (40 g) measurably increased satiety at multiple timepoints—evidence for longer‑lasting fullness.
- Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults: A Randomized Clinical Trial
PubMed ID: 33252690
High-fiber vegan diet produced weight loss and increased thermic effect of food; increased fiber plausibly contributed to prolonged satiety/fullness.
- A Coaching Program to Improve Dietary Intake of Patients with CKD: ENTICE-CKD
PubMed ID: 32111701
Dietary increases in fiber were associated with weight loss in exploratory analyses, consistent with increased satiety/longer fullness.
- Dietary Fibres and the Management of Obesity and Metabolic Syndrome: The RESOLVE Study
PubMed ID: 32977595
Increased fiber intake during a supervised weight‑loss program correlated with better fat loss and metabolic improvements, consistent with improved satiety/longer fullness.
- Effect of a functional fibre supplement on glycemic control when added to a year-long medically supervised weight management program in adults with type 2 diabetes
PubMed ID: 32642971
Viscous fiber (PGX) produced sustained weight loss when used with a weight‑loss program, consistent with increased satiety/longer fullness.
- Policaptil Gel Retard Intake Reduces Postprandial Triglycerides, Ghrelin and Appetite in Obese Children: A Clinical Trial
PubMed ID: 31947628
Premeal polysaccharide fiber reduced appetite hormones (ghrelin) and subjective appetite in children, consistent with increased fullness.
- Consuming a Protein and Fiber-Based Supplement Preload Promotes Weight Loss and Alters Metabolic Markers in Overweight Adults in a 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 35212740
Pre‑meal protein+fiber preload is designed to extend fullness and the trial produced greater weight loss consistent with prolonged satiety.
- Flaxseed Mucilage (IQP-LU-104) Reduces Body Weight in Overweight and Moderately Obese Individuals in a 12-week, Three-Arm, Double-Blind, Randomized, and Placebo-Controlled Clinical Study
PubMed ID: 35130547
Flaxseed mucilage resulted in significant weight/fat loss consistent with increased and sustained satiety from viscous fiber.
- Short-Term Effect of Additional Daily Dietary Fibre Intake on Appetite, Satiety, Gastrointestinal Comfort, Acceptability, and Feasibility
PubMed ID: 36235865
Qualitative reports of increased fullness and reduced snacking after barley fiber in a short feasibility study.
- HIGH-FIBER DIET PROMOTES METABOLIC, HORMONAL, AND SATIETY EFFECTS IN OBESE WOMEN ON A SHORT-TERM CALORIC RESTRICTION
PubMed ID: 37556741
High‑fiber diet increased satiety and suppressed acylated ghrelin after meals in obese women.
- Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial
PubMed ID: 37793780
Inulin reduced wanting/hunger measures and altered reward‑area activation, consistent with prolonged fullness.
- Effects of combined prebiotic fiber supplementation and weight loss counseling in adults with metabolic dysfunction-associated steatotic liver disease: a randomized controlled trial
PubMed ID: 40172664
Inulin decreased hunger/desire to eat, consistent with longer-lasting fullness.
- Association between the gut microbiota composition and alpha-diversity on the hormonal response and appetitive measures of individuals with obesity after a meal either rich in ultra-processed foods or without ultra-processed foods: Secondary analysis of a randomized clinical trial
PubMed ID: 40912360
Higher microbiota diversity (linked to fiber intake) associated with greater post‑meal fullness.
- Effects of brown rice bran on appetite and depression in metabolic syndrome: a secondary analysis of an open-label randomised controlled trial
PubMed ID: 41190469
Brown rice bran powder increased subjective satiety/fullness in an RCT.
- [Effect of quinua (Chenopodium quinoa)consumption as a coadjuvant in nutritional intervention in prediabetic subjects]
PubMed ID: 29130716
Processed quinoa increased feelings of fullness versus placebo over 28 days.
- Type-4 Resistant Starch in Substitution for Available Carbohydrate Reduces Postprandial Glycemic Response and Hunger in Acute, Randomized, Double-Blind, Controlled Study
PubMed ID: 29373530
RS4 replacement reduced hunger and desire to eat, indicating greater satiety duration
- Adolescents perceive a low added sugar adequate fiber diet to be more satiating and equally palatable compared to a high added sugar low fiber diet in a randomized-crossover design controlled feeding pilot trial
PubMed ID: 29751193
Higher-fiber adolescent diet increased fullness ratings
- Weight loss and metabolic health effects from energy-restricted Mediterranean and Central-European diets in postmenopausal women: A randomized controlled trial
PubMed ID: 30042488
Higher fiber intake correlated with visceral fat loss in adherent participants; fiber commonly increases satiety though not directly measured.
- Impact of Diets Rich in Whole Grains and Fruits and Vegetables on Cardiovascular Risk Factors in Overweight and Obese Women: A Randomized Clinical Feeding Trial
PubMed ID: 29702040
Whole-grain (fiber-rich) weight-loss diet produced greater weight/waist improvements—consistent with increased satiety and longer fullness.
- Postprandial glucose-lowering effect of premeal consumption of protein-enriched, dietary fiber-fortified bar in individuals with type 2 diabetes mellitus or normal glucose tolerance
PubMed ID: 29502350
Premeal bar with 12.7 g fiber increased GLP‑1 and reduced postprandial glucose/insulin—strong evidence for increased and longer satiety.
- A Plant-Based High-Carbohydrate, Low-Fat Diet in Overweight Individuals in a 16-Week Randomized Clinical Trial: The Role of Carbohydrates
PubMed ID: 30223451
Plant-based high-fiber diet increased fiber intake by ~15 g/day and produced weight loss — consistent with improved satiety and fullness over time.
- A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
PubMed ID: 30425247
Postprandial PYY increased after the cereal‑fiber change, consistent with greater/longer satiety.
- A proof-of-concept study to evaluate the efficacy and safety of BTI320 on post-prandial hyperglycaemia in Chinese subjects with pre-diabetes
PubMed ID: 30170579
Galactomannan reduced postprandial glucose excursions and produced modest weight loss, implying improved satiety/meal control.
- Effect of High Fiber Cereal Intake on Satiety and Gastrointestinal Symptoms during Ramadan
PubMed ID: 31027300
High-fiber breakfast cereal sharply increased short-term fullness (large RCT effect) after pre-dawn meal.
- Impact of oat processing on glycaemic and insulinaemic responses in healthy humans: a randomised clinical trial
PubMed ID: 31068229
Less-processed oats produced lower postprandial glucose/insulin, which is associated with prolonged satiety compared with more processed carbs.
- Weight loss at your fingertips: personalized nutrition with fasting glucose and insulin using a novel statistical approach
PubMed ID: 30967642
High-fiber whole-diet (NND) was associated with greater weight loss in some subgroups, consistent with improved fullness/energy intake control.
- Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
PubMed ID: 25500202
Increased PYY/GLP‑1 and reduced acute meal size indicate stronger evidence for increased/longer satiety.
- Changes in visceral adiposity and serum cholesterol with a novel viscous polysaccharide in Japanese adults with abdominal obesity
PubMed ID: 23512917
PGX is a viscous fiber; trial showed reductions in waist/visceral fat and glucose AUC changes consistent with increased satiety/longer fullness.
- Daily consumption of a synbiotic yogurt decreases energy intake but does not improve gastrointestinal transit time: a double-blind, randomized, crossover study in healthy adults
PubMed ID: 23787118
Synbiotic with inulin was associated with lower energy intake, suggesting increased satiety/longer fullness.
- A natural fiber complex reduces body weight in the overweight and obese: a double-blind, randomized, placebo-controlled study
PubMed ID: 23505169
Large weight loss with fiber complex suggests increased satiety/fullness contributed, though fullness not directly measured.
- Satiety and energy intake after single and repeated exposure to gel-forming dietary fiber: post-ingestive effects
PubMed ID: 24030518
Gelled pectin produced acute reductions in food intake and increased satiety markers—supports longer‑lasting fullness acutely.
- The effects of bulking, viscous and gel-forming dietary fibres on satiation
PubMed ID: 22850326
Gel-forming alginate increased oral exposure time and reduced ad libitum intake substantially—strong evidence for increased meal-related fullness/satiation.
- Flaxseed dietary fiber supplements for suppression of appetite and food intake
PubMed ID: 22245724
Soluble flaxseed fiber increased subjective fullness and reduced energy intake at the next meal in randomized crossover trials.
- Low glycemic load experimental diet more satiating than high glycemic load diet
PubMed ID: 22564018
Low‑glycemic‑load (higher fiber) diet increased satiety and reduced reported cravings in a controlled feeding study.
- Effect of alginate supplementation on weight loss in obese subjects completing a 12-wk energy-restricted diet: a randomized controlled trial
PubMed ID: 22648709
Alginate (soluble fiber) group lost more weight/fat in completers, consistent with increased satiety/longer-lasting fullness (conditional evidence).
- Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults
PubMed ID: 21414045
HVP soluble fiber increased fullness ratings and produced modest weight loss—strongest human evidence in dataset for sustained satiety.
- Rye kernel breakfast increases satiety in the afternoon - an effect of food structure
PubMed ID: 21481225
Whole-grain rye breakfasts increased satiety into the afternoon compared with refined wheat, indicating longer-lasting fullness.
- Effects of NUTRIOSE® dietary fiber supplementation on body weight, body composition, energy intake, and hunger in overweight men
PubMed ID: 21591985
NUTRIOSE supplementation reduced hunger and energy intake across 12 weeks, consistent with longer-lasting satiety.
- The soluble fiber NUTRIOSE induces a dose-dependent beneficial impact on satiety over time in humans
PubMed ID: 22024490
Dose- and time-dependent increases in satiety and reduced hunger with NUTRIOSE soluble fiber; 24 g/day prolonged time-to-hunger — very strong evidence.
- Comparison of high protein and high fiber weight-loss diets in women with risk factors for the metabolic syndrome: a randomized trial
PubMed ID: 21524314
High‑fiber, wholegrain/legume diet increased fiber by ~13 g/day and both diets produced weight/fat loss—fiber likely contributed to satiety and longer fullness.
- Short-term effects of a snack including dried prunes on energy intake and satiety in normal-weight individuals
PubMed ID: 20434071
Prune snack increased fullness and reduced subsequent energy intake at the next meal — clear acute satiety effect.
- Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults
PubMed ID: 20664618
PGX influenced PYY (satiety hormone) and prevented its decline, supporting prolonged fullness in some participants.
- Regular consumption of a cereal breakfast. Effects on mood and body image satisfaction in adult non-obese women
PubMed ID: 20832439
Cereal breakfast (perceived higher-fibre) produced greater fullness and improved mood/body satisfaction — evidence for longer satiety.
- NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
PubMed ID: 21164548
NUTRIOSE supplementation led to weight/fat reductions; resistant dextrins can promote satiety and longer fullness.
- Chickpea supplementation in an Australian diet affects food choice, satiety and bowel health
PubMed ID: 19945492
Chickpea supplementation increased perceived fullness in a 12‑week trial.
- Viscosity of fiber preloads affects food intake in adolescents
PubMed ID: 19157816
A high-viscosity fiber preload reduced subsequent meal intake by ~10–12% in adolescents, implying more sustained satiety/longer-lasting fullness between meals.
- Pretreatment Fasting Glucose and Insulin as Determinants of Weight Loss on Diets Varying in Macronutrients and Dietary Fibers-The POUNDS LOST Study
PubMed ID: 30861997
Higher fiber intake during energy-restricted diets associated with significantly greater long-term weight loss—consistent with prolonged satiety and reduced intake.
- Effect of rye bread breakfasts on subjective hunger and satiety: a randomized controlled trial
PubMed ID: 19709412
Rye (high‑fiber) breakfasts produced greater morning satiety and reduced hunger than wheat—evidence of extended fullness.
- A randomized behavioural trial targeting glycaemic index improves dietary, weight and metabolic outcomes in patients with type 2 diabetes
PubMed ID: 19161649
Increased fiber intake in a behavioral program coincided with BMI reduction — consistent with increased satiety/longer fullness.
- High intake of fruits and vegetables predicts weight loss in Brazilian overweight adults
PubMed ID: 19083413
Increases in fruit/vegetable-derived fiber during counseling were associated with modest weight loss, consistent with fiber producing greater satiety/longer fullness.
- A low-energy-dense diet adding fruit reduces weight and energy intake in women
PubMed ID: 18439712
Daily apples or pears reduced energy intake and produced modest weight loss vs oat cookies despite similar fiber amounts — consistent with longer lasting satiety from low energy‑density, intact fruit.
- Hydroxypropylmethylcellulose and methylcellulose consumption reduce postprandial insulinemia in overweight and obese men and women
PubMed ID: 18203894
Viscous fibers blunt postprandial insulin/glucose peaks—physiologic basis for more sustained satiety.
- Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial
PubMed ID: 18031592
Soluble-fiber supplement significantly increased postprandial fullness in a randomized trial—direct support for longer-lasting fullness.
- Improvement of insulin resistance after diet with a whole-grain based dietary product: results of a randomized, controlled cross-over study in obese subjects with elevated fasting blood glucose
PubMed ID: 17562226
Whole‑grain, fiber‑rich replacement attenuated insulin measures and supported weight loss—consistent with improved satiety signals.
- Food cravings and energy regulation: the characteristics of craved foods and their relationship with eating behaviors and weight change during 6 months of dietary energy restriction
PubMed ID: 17593902
Observational evidence links craving patterns to low dietary fiber, implying higher fiber could increase satiety/longer fullness.
- Lupin-enriched bread increases satiety and reduces energy intake acutely
PubMed ID: 17093146
Lupin bread (higher fiber/protein) increased satiety and reduced subsequent intake in acute trials.
- Effect of a viscous fiber-containing nutrition bar on satiety of patients with type 2 diabetes
PubMed ID: 17023088
Viscous fiber bar produced a sizable (+27%) increase in subjective fullness and increased fullness AUC.
- Glucagon-like peptide-1 release and satiety after a nutrient challenge in normal-weight and obese subjects
PubMed ID: 16022753
Guar gum increased satiety (subjective) at 30–60 min in normal-weight subjects — evidence for more lasting fullness.
- Experiences with three different fiber supplements in weight reduction
PubMed ID: 15614200
Viscous fiber supplements produced greater short-term weight loss consistent with prolonged satiety/fullness between meals.
- Effects of agar (kanten) diet on obese patients with impaired glucose tolerance and type 2 diabetes
PubMed ID: 15642074
Agar (a gel-forming fiber) produced greater weight loss vs control, consistent with appetite suppression/lasting fullness.
- Inclusion of guar gum and alginate into a crispy bar improves postprandial glycemia in humans
PubMed ID: 15051842
Viscous fibres blunted and slowed postprandial glucose peaks—consistent with prolonged gastric residence and satiety.
- Longitudinal changes in body weight and body composition among women previously treated for breast cancer consuming a high-vegetable, fruit and fiber, low-fat diet
PubMed ID: 15309460
Short-term weight/fat loss after higher-fibre intervention suggests increased fullness contributed (not sustained).
- Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial
PubMed ID: 14744846
Ad libitum high-fibre diet produced spontaneous weight loss consistent with increased satiety/longer fullness between meals.
- Effects of a beverage containing an enzymatically induced-viscosity dietary fiber, with or without fructose, on the postprandial glycemic response to a high glycemic index food in humans
PubMed ID: 12947431
Viscosity-forming guar gum slows nutrient absorption and is associated with increased satiety/longer-lasting fullness in humans (direct glycemic and viscoelastic evidence).
- Low glycemic index breakfasts and reduced food intake in preadolescent children
PubMed ID: 14595085
Low-GI breakfasts (often higher in fiber) led to reduced lunch intake in children, consistent with prolonged satiety.
- Ready-to-eat cereal used as a meal replacement promotes weight loss in humans
PubMed ID: 12480804
Ready-to-eat cereal meal replacement reduced energy intake and produced short-term weight loss—supports longer-lasting fullness (meal structure often includes fibre).
- Long-term effect of fibre supplement and reduced energy intake on body weight and blood lipids in overweight subjects
PubMed ID: 11294130
Fibre supplement added to a low-calorie diet produced greater weight loss — consistent with increased satiety/longer-lasting fullness as mechanism.
- [Evaluation of the action of glucomannan on metabolic parameters and on the sensation of satiation in overweight and obese patients]
PubMed ID: 7796558
Glucomannan is a viscous fiber; when added to diet it improved weight/energy outcomes consistent with prolonged satiety.
- [Chronic use of glucomannan in the dietary treatment of severe obesity]
PubMed ID: 1313163
Glucomannan is a viscous fiber associated with increased satiety and improved diet adherence/weight loss in the trial.
- Efficacy of rifaximin on symptoms of uncomplicated diverticular disease of the colon. A pilot multicentre open trial. Diverticular Disease Study Group
PubMed ID: 1330083
Glucomannan is a soluble viscous fibre that clinically improved symptoms and is known to increase satiety / fullness duration.
- A dietary fibre supplement in the treatment of mild hypertension. A randomized, double-blind, placebo-controlled trial
PubMed ID: 1313484
Fibre supplement produced weight loss, consistent with increased satiety/longer fullness.
- Influence of two guar preparations on glycosylated hemoglobin, total cholesterol and triglycerides in patients with diabetes mellitus
PubMed ID: 1335441
Guar fibre lowered long-term glycemic marker and is a viscous fibre classically linked to prolonged satiety.
- Overweight treated with energy restriction and a dietary fibre supplement: a 6-month randomized, double-blind, placebo-controlled trial
PubMed ID: 2172178
Fibre supplement with energy restriction reduced hunger VAS and produced greater weight loss — supports increased/sustained satiety.
- Eating rate of commonly consumed foods promotes food and energy intake
PubMed ID: 21094194
Higher‑fibre foods were eaten more slowly; slower eating associated with lower intake—supports longer perceived fullness indirectly.
- Impact of some isoenergetic snacks on satiety and next meal intake in healthy adults
PubMed ID: 19743984
Fibre‑enriched yogurt produced greater short‑term fullness and reduced subsequent intake vs lower‑fibre comparators in a controlled human trial.
- Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice
PubMed ID: 23207186
Inulin-based soluble fermentable fiber reduced hunger AUC and decreased ad libitum intake, consistent with more sustained fullness.
- The effects of chitosan supplementation on anthropometric indicators of obesity, lipid and glycemic profiles, and appetite-regulated hormones in adolescents with overweight or obesity: a randomized, double-blind clinical trial
PubMed ID: 36064382
Chitosan altered appetite hormones (leptin/adiponectin) and reduced weight/waist, suggesting effects on satiety/fullness.
- The efficacy of daily snack replacement with oligofructose-enriched granola bars in overweight and obese adults: a 12-week randomised controlled trial
PubMed ID: 29490721
Oligofructose reduced subjective hunger, consistent with increased satiety/longer-lasting fullness though no change in intake or weight.
- Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis
PubMed ID: 29777234
Greater weight/fat loss on higher-fiber diets (in people with certain microbiomes) is consistent with increased satiety/longer fullness, though satiety was not directly measured.
- Daily ingestion of alginate reduces energy intake in free-living subjects
PubMed ID: 18655817
Premeal alginate reduced daily energy intake in free‑living adults, consistent with prolonged satiety between meals.
- [The use of highly purified glucomannan-based fibers in childhood obesity]
PubMed ID: 1324483
Glucomannan (viscous fiber) in obese children associated with weight/triglyceride reductions, mechanism plausibly increased satiety.
- The Effects of High Fiber Rye, Compared to Refined Wheat, on Gut Microbiota Composition, Plasma Short Chain Fatty Acids, and Implications for Weight Loss and Metabolic Risk Factors (the RyeWeight Study)
PubMed ID: 35458231
Hypocaloric high-fiber rye in weight-loss setting likely prolongs fullness, supporting adherence—satiety not primary reported endpoint but plausible.
- Modulation of amino acid metabolic signatures by supplemented isoenergetic diets differing in protein and cereal fiber content
PubMed ID: 25157543
Cereal-fiber intake changed metabolic signals and amino-acid profiles tied to satiety/metabolic state.
- Effect of Walnut Predinner Snack on Mealtime Hunger and Nutrient Intake Among University Students
PubMed ID: 34714144
Walnut snack increased premeal fullness and reduced mealtime intake (short-term satiety extension).
- Added soluble fiber enhances the satiating power of low-energy-density liquid yogurts
PubMed ID: 19857627
Inulin in yogurt increased fullness and reduced intake at the subsequent meal (sustained satiety effect).
- Instant Oatmeal Increases Satiety and Reduces Energy Intake Compared to a Ready-to-Eat Oat-Based Breakfast Cereal: A Randomized Crossover Trial
PubMed ID: 26273900
Instant oatmeal increased fullness AUC and decreased next‑meal intake by ~85 kcal—strong acute fullness effect.
- Impact of Agaricus bisporus mushroom consumption on satiety and food intake
PubMed ID: 28647383
Higher-fiber mushroom meal increased fullness/hunger ratings versus meat (short-term study).
- Enrichment of biscuits and juice with oat β-glucan enhances postprandial satiety
PubMed ID: 24434584
Dose‑dependent increases in postprandial satiety with oat bran enrichment, especially at higher doses.
- Acute effect of oatmeal on subjective measures of appetite and satiety compared to a ready-to-eat breakfast cereal: a randomized crossover trial
PubMed ID: 24024772
Oatmeal increased fullness and reduced hunger vs ready‑to‑eat oat cereal throughout the morning.
- Addition of Rye Bran and Pea Fiber to Pork Meatballs Enhances Subjective Satiety in Healthy Men, but Does Not Change Glycemic or Hormonal Responses: A Randomized Crossover Meal Test Study
PubMed ID: 28794212
Rye bran + pea fiber increased subjective fullness and reduced hunger in men after a meal (acute trial).
- Effect of Barley on Postprandial Blood Glucose Response and Appetite in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39599684
Barley fiber drink significantly lowered hunger VAS and increased satiety after meals in a randomized crossover—strong evidence for longer fullness.
- Using the Avocado to Test the Satiety Effects of a Fat-Fiber Combination in Place of Carbohydrate Energy in a Breakfast Meal in Overweight and Obese Men and Women: A Randomized Clinical Trial
PubMed ID: 31035472
Whole‑avocado breakfast significantly suppressed hunger for hours and increased PYY; fiber is a likely contributor to prolonged satiety.
- An Anthocyanin-Rich Mixed-Berry Intervention May Improve Insulin Sensitivity in a Randomized Trial of Overweight and Obese Adults
PubMed ID: 31775396
Lower postprandial insulin exposure with berries may contribute to more sustained satiety.
- Gastrointestinal microbiome modulator improves glucose tolerance in overweight and obese subjects: A randomized controlled pilot trial
PubMed ID: 26424589
Inulin + β‑glucan increased subjective fullness and reduced desire to eat in RCT.
- The Impact of Glucomannan, Inulin, and Psyllium Supplementation (Soloways(TM)) on Weight Loss in Adults with FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 38398881
RCT showed substantially increased postprandial satiety scores with glucomannan+inulin+psyllium, indicating longer fullness.
- Development and empirical evaluation of a dietary intervention programme for individuals with prediabetes based on the health action process approach: A randomised controlled trial
PubMed ID: 41421300
Program increased fibre‑rich choices and reduced BMI, suggesting improved appetite regulation and fullness over time.
- Comparison of Low-Gluten Diets Rich in Oats or Rice-A 6-Week Randomized Clinical Trial With Metabolically Challenged Volunteers
PubMed ID: 40331457
Higher‑fibre oat diet associated with waist reduction and changes consistent with increased satiety.
- The effects of functional fiber on postprandial glycemia, energy intake, satiety, palatability and gastrointestinal wellbeing: a randomized crossover trial
PubMed ID: 25066659
Functional fibers in bread reduced postprandial glycemia and modestly reduced next-meal energy intake (supports sustained fullness).
- Effects of whole grain rye crisp bread for breakfast on appetite and energy intake in a subsequent meal: two randomised controlled trails with different amounts of test foods and breakfast energy content
PubMed ID: 24661836
Whole-grain rye breakfast reduced hunger and increased satiety vs refined wheat (longer satiation).
- An enriched, cereal-based bread affects appetite ratings and glycemic, insulinemic, and gastrointestinal hormone responses in healthy adults in a randomized, controlled trial
PubMed ID: 25644342
Cereal bread enriched with fiber+protein increased satiety AUC vs white bread (strong acute evidence for prolonged fullness).
- The impact of soluble dietary fibre on gastric emptying, postprandial blood glucose and insulin in patients with type 2 diabetes
PubMed ID: 24901089
Oat β‑glucan delayed gastric emptying and lowered postprandial glucose/insulin in T2D — supports prolonged satiety.
- Effect of two dietary fibers on satiety and glycemic parameters: a randomized, double-blind, placebo-controlled, exploratory study
PubMed ID: 24886409
Oligofructose+pectin showed appetite/fullness trends and reduced intake in some comparisons.
- Effects of different amounts of konjac flour inclusion in gestation diets on physio-chemical properties of diets, postprandial satiety in pregnant sows, lactation feed intake of sows and piglet performance
PubMed ID: 25466211
Konjac (glucomannan) increased GLP‑1 and satiety markers in animal model → supports prolonged fullness.
- Satiety effects of a whole-grain fibre composite ingredient: reduced food intake and appetite ratings
PubMed ID: 25138661
Trial showed reduced hunger ratings for ~2–3 hours after dosing and lower later energy intake, indicating prolonged satiety.
- α-Galacto-oligosaccharides Dose-Dependently Reduce Appetite and Decrease Inflammation in Overweight Adults
PubMed ID: 26180243
α‑GOS increased satiety AUC dose‑dependently, indicating more sustained feelings of fullness.
- Weight Maintenance with Litramine (IQP-G-002AS): A 24-Week Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 26435849
Litramine trial: 60% reported increased satiety vs 12.5% on placebo—supports longer-lasting fullness.
- Effects of two dietary fibers as part of ready-to-eat cereal (RTEC) breakfasts on perceived appetite and gut hormones in overweight women
PubMed ID: 25689743
Cereal fibers increased GLP‑1 and PYY (physiologic fullness signals) though acute perceived fullness did not change in the trial.
- Effects of oatmeal and corn flakes cereal breakfasts on satiety, gastric emptying, glucose, and appetite-related hormones
PubMed ID: 25612907
Oatmeal (soluble fiber) significantly increased fullness AUC and reduced subsequent intake—strong evidence for lasting fullness.
- Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial
PubMed ID: 27810310
Prebiotic+probiotic combination reduced energy intake and daily intake in some analyses, consistent with increased satiety.
- Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial
PubMed ID: 26811130
Pea fiber (15 g/d) produced reduced energy intake at the following meal, reflecting greater satiety/longer fullness.
- The effects of the combination of egg and fiber on appetite, glycemic response and food intake in normal weight adults - a randomized, controlled, crossover trial
PubMed ID: 27306734
A breakfast with moderate protein+fiber increased satiety and reduced subsequent intake vs low‑protein cereal (acute effect).
- Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial)
PubMed ID: 27733151
Psyllium is known to promote satiety; the trial showed weight loss consistent with sustained appetite effects.
- Acute effects of different dietary polysaccharides added in milk on food intake, postprandial appetite and glycemic responses in healthy young females
PubMed ID: 27352777
Guar gum/alginate acutely reduced appetite and subsequent meal intake—strong evidence for short‑term prolonged fullness with viscous fibers.
- Glycemic Index of a Novel High-Fiber White Rice Variety Developed in India--A Randomized Control Trial Study
PubMed ID: 26741823
High‑fiber white rice with higher resistant starch reduced GI—lower glycemia/resistant starch profile supports more sustained satiety relative to standard white rice.
- Prebiotic supplementation improves appetite control in children with overweight and obesity: a randomized controlled trial
PubMed ID: 28228425
Oligofructose increased subjective fullness in children after chronic supplementation.
- Co-administration of a konjac-based fibre blend and American ginseng (Panax quinquefolius L.) on glycaemic control and serum lipids in type 2 diabetes: a randomized controlled, cross-over clinical trial
PubMed ID: 28687934
Konjac glucomannan is a viscous fiber associated with prolonged gastric emptying and increased fullness; study demonstrated glycemic improvements supportive of satiety effects.
- Effect on Insulin, Glucose and Lipids in Overweight/Obese Australian Adults of 12 Months Consumption of Two Different Fibre Supplements in a Randomised Trial
PubMed ID: 28146065
PGX (viscous fiber) is known to increase satiety; trial showed metabolic benefits although satiety was not a primary endpoint.
- Effect of Fibre Supplementation on Body Weight and Composition, Frequency of Eating and Dietary Choice in Overweight Individuals
PubMed ID: 28212353
PGX (viscous fiber) reduced number of eating occasions, consistent with longer-lasting satiety.
- The effect of soluble fiber dextrin on postprandial appetite and subsequent food intake in healthy adults
PubMed ID: 29429537
20 g soluble fiber dextrin increased subjective fullness (acute, no short-term intake change).
Bloating & gas (63)
- Efficacy and safety of Gelidium elegans intake on bowel symptoms in obese adults: A 12-week randomized double-blind placebo-controlled trial
PubMed ID: 31027051
Gelidium elegans reduced abdominal discomfort in RCT, consistent with less bloating.
- Daily intake of wheat germ-enriched bread may promote a healthy gut bacterial microbiota: a randomised controlled trial
PubMed ID: 31325040
Wheat germ added to bread increased beneficial taxa and reduced GI-related worries — plausible reduction in bloating/discomfort.
- Nopal fiber (Opuntia ficus-indica) improves symptoms in irritable bowel syndrome in the short term: a randomized controlled trial
PubMed ID: 32935904
Nopal-fiber RCT in IBS showed high rates of symptom relief and clinically meaningful symptom reductions (direct evidence for reduced bloating).
- Effects of rice-based and wheat-based diets on bowel movements in young Korean women with functional constipation
PubMed ID: 32322048
Whole-grain/brown-rice diet shortened colonic transit time and increased stool frequency, which can reduce bloating (moderate evidence).
- Soluble Dietary Fiber Reduces Feeding Intolerance in Severe Acute Pancreatitis: A Randomized Study
PubMed ID: 32141126
Soluble fiber (polydextrose) markedly reduced abdominal distension in severe-AP patients (large, clinically meaningful effect).
- Intake of okara soup for 2 weeks for breakfast improved defecation habits in young Japanese women with self-reported constipation: A randomized, double-blind, placebo-controlled, intervention study
PubMed ID: 32885419
Okara (soy fiber) soup reduced abdominal bloating vs placebo in constipated young women (randomized trial).
- The effects of abdominal "I LOV U" massage along with lifestyle training on constipation and distension in the elderly with stroke
PubMed ID: 33465382
Abdominal "I LOV U" massage RCT reduced belly distension in elderly stroke patients — directly relevant to reducing bloating (intervention not fiber but outcome aligned).
- A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial
PubMed ID: 28870194
Yeast fermentate pilot reduced bloating/fullness in participants (prebiotic-like effect), supporting reduced bloating.
- Gut Permeability Might be Improved by Dietary Fiber in Individuals with Nonalcoholic Fatty Liver Disease (NAFLD) Undergoing Weight Reduction
PubMed ID: 30453660
Diet raising fiber lowered zonulin (gut permeability) and improved symptoms—consistent with less bloating/gut discomfort.
- Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
PubMed ID: 35300378
Konjac glucomannan can reduce GI discomfort and shifts microbiota; plausible reduction in bloating reported in fiber trials.
- Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs
PubMed ID: 28740352
Low-FODMAP trial produced large IBS symptom reductions (including bloating); fiber was manipulated but reintroduction not harmful — relevant to bloating relief.
- A Symbiotic Meal Containing Extruded Sorghum and Probiotic (Bifidobacterium longum) Ameliorated Intestinal Health Markers in Individuals with Chronic Kidney Disease: A Secondary Analysis of a Subsample from a Previous Randomized and Controlled Clinical Trial
PubMed ID: 38931207
Symbiotic meal improved bowel habits and GI symptoms in dialysis patients, consistent with reduced bloating.
- [Effect of ear mushroom (Auricularia) on functional constipation]
PubMed ID: 15266131
Ear-mushroom (high-fiber) RCT in constipated adults improved stool symptoms (incomplete evacuation and consistency), which commonly co-occur with bloating.
- [Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study]
PubMed ID: 29378102
Inulin-containing jelly significantly reduced bloating in IBS-C patients (clinical improvement reported).
- Effects of Resistant Glucan Mixture on Bowel Movement in Female Volunteers
PubMed ID: 27117853
Resistant glucan increased stool frequency/volume in constipated women — likely to relieve bloating via reduced stool burden (direct human evidence).
- Combinations of laxatives and green banana biomass on the treatment of functional constipation in children and adolescents: a randomized study
PubMed ID: 29309737
Green banana reduced abdominal pain and straining in constipated children, implying less bloating.
- A comparison of mebeverine with high-fibre dietary advice and mebeverine plus ispaghula in the treatment of irritable bowel syndrome: an open, prospectively randomised, parallel group study
PubMed ID: 2177997
Ispaghula/high-fibre advice improved IBS symptoms including pain/bloating vs baseline (large RCT).
- Lactulose in the treatment of symptomatic diverticular disease: a comparative study with high-fibre diet
PubMed ID: 2169839
High-fibre diet improved symptoms in symptomatic diverticular disease including abdominal pain/bloating.
- The value of prescribed 'high-fibre' diets for the treatment of the irritable bowel syndrome
PubMed ID: 1667298
Higher daily fiber (>30 g/d) in IBS patients associated with improved stool consistency and reduced constipation/urgency—likely reduces bloating and distension symptoms.
- Efficacy of rifaximin on symptoms of uncomplicated diverticular disease of the colon. A pilot multicentre open trial. Diverticular Disease Study Group
PubMed ID: 1330083
Glucomannan reduced global symptoms in diverticular disease (likely includes bloating) in a clinical trial.
- [Use of glucomannan dietary fiber in changes in intestinal habit]
PubMed ID: 8566676
Glucomannan RCT showed increased bowel movements without increased flatulence/diarrhea—suggests it does not worsen gas and may reduce sensation of bloating.
- The effect of dietary fiber on bowel function following radical hysterectomy: a randomized trial
PubMed ID: 9299255
Higher-fiber dietary advice after hysterectomy improved bowel emptying and reduced straining — plausible reduction in bloating/abdominal discomfort though bloating not measured directly.
- High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial comparison between wheat bran diet and partially hydrolyzed guar gum (PHGG)
PubMed ID: 12184518
PHGG (soluble fiber) reduced IBS symptoms and was better tolerated than bran, implying reduced bloating/abdominal discomfort.
- Rifaximin improves symptoms of acquired uncomplicated diverticular disease of the colon
PubMed ID: 12458383
Glucomannan improved diverticular symptoms (less symptomatic disease), which commonly includes reduced bloating.
- The efficacy of cisapride vs. placebo and diet in patients with chronic constipation
PubMed ID: 12974147
High-fiber diet phase in chronic constipation trial improved stool frequency/straining/incomplete evacuation, which commonly reduces bloating and discomfort.
- Paroxetine to treat irritable bowel syndrome not responding to high-fiber diet: a double-blind, placebo-controlled trial
PubMed ID: 15128360
High-fiber diet in IBS reduced bloating in ~26% of patients (direct symptom evidence).
- Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A multicenter randomized open trial
PubMed ID: 15986863
PHGG (fiber) improved IBS gut symptoms/QoL (likely including bloating) during treatment.
- Efficacy of long term cyclic administration of the poorly absorbed antibiotic Rifaximin in symptomatic, uncomplicated colonic diverticular disease
PubMed ID: 17226906
Dietary fiber alone reduced diverticular symptoms over 24 months (symptom score improvement), consistent with reduced bloating/abdominal discomfort.
- [Efficacy of newly developed kombucha-based specialized food product for treatment of constipation-predominant irritable bowel syndrome]
PubMed ID: 36394933
Inulin‑enriched kombucha improved stool form and reduced incomplete evacuation in IBS‑C, which often accompanies reduced bloating/abdominal discomfort (direct GI symptom benefit).
- Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial
PubMed ID: 19713235
Psyllium (soluble fiber) RCT in primary-care IBS patients produced clinically meaningful symptom relief including reductions in bloating/overall IBS symptoms.
- [Efficacy of using inulin fortified fermented milk products in patients with functional constipation]
PubMed ID: 19663305
Inulin-fortified products improved constipation symptoms and QoL in constipated patients—likely to reduce bloating as part of symptom improvement (not all products).
- Can partially hydrolyzed guar gum be an alternative to lactulose in treatment of childhood constipation?
PubMed ID: 21331988
PHGG in constipated children improved abdominal pain and stool consistency — likely to improve gut comfort and reduce some bloating-related symptoms.
- Clinical trial: the combination of rifaximin with partially hydrolysed guar gum is more effective than rifaximin alone in eradicating small intestinal bacterial overgrowth
PubMed ID: 20937045
Adjunctive soluble fiber (partially hydrolysed guar) increased SIBO eradication; treating SIBO is likely to reduce bloating symptoms.
- Linking long-term dietary patterns with gut microbial enterotypes
PubMed ID: 21885731
Long‑term high‑fiber diets associated with faster transit and enterotypes linked to less gut discomfort; plausible reduction in bloating.
- Perceptions of flatulence from bean consumption among adults in 3 feeding studies
PubMed ID: 22104320
Bean-feeding trials show initial rise in gas but symptoms usually decline over 2–3 weeks — supports eventual reduction/adaptation of bloating with increased legume (fiber) intake.
- Efficacy of Lactobacillus paracasei sub. paracasei F19 on abdominal symptoms in patients with symptomatic uncomplicated diverticular disease: a pilot study
PubMed ID: 21372765
Study in diverticular patients: probiotic + high‑fiber diet produced meaningful reductions in bloating (confounded by probiotic).
- [Influence of fiberform on defecation condition after surgery for benign anorectal lesion]
PubMed ID: 22205452
Postoperative fiber improved stool consistency and eased defecation, which commonly reduces bloating/abdominal discomfort.
- High-fibre diet and Lactobacillus paracasei B21060 in symptomatic uncomplicated diverticular disease
PubMed ID: 23139608
High‑fibre diet reduced abdominal pain and bloating in uncomplicated diverticular disease (clinical symptom improvement).
- Polydextrose and soluble corn fiber increase five-day fecal wet weight in healthy men and women
PubMed ID: 23427334
Polydextrose/soluble corn fiber softened stool and increased output; mild flatulence reported—may reduce bloating for some via improved transit.
- Partially hydrolyzed guar gum in pediatric functional abdominal pain
PubMed ID: 23345946
PHGG reduced IBS symptoms and abdominal pain in children, consistent with less bloating.
- [Clinical benefits after soluble dietary fiber supplementation: a randomized clinical trial in adults with slow-transit constipation]
PubMed ID: 25623312
Pectin sped transit time and eased constipation symptoms, which commonly reduces bloating.
- Effect of inulin and fructo-oligosaccharide on the prevention of acute radiation enteritis in patients with gynecological cancer and impact on quality-of-life: a randomized, double-blind, placebo-controlled trial
PubMed ID: 26603881
Inulin+FOS (prebiotic fiber) trial in pelvic radiotherapy patients showed improved stool consistency and trends toward fewer watery stools, supporting reduced GI discomfort including bloating.
- Effect of Polydextrose Intake on Constipation in Japanese Dialysis Patients: A Triple-Blind, Randomized, Controlled Trial
PubMed ID: 26440643
Polydextrose trial in constipated patients reported improved bowel symptoms and no increase in abdominal pain/bloating (symptoms relieved).
- [Efficacy of pectin in the treatment of diarrhea predominant irritable bowel syndrome]
PubMed ID: 25809332
Pectin RCT in IBS‑D reduced composite symptoms and improved stool form (likely includes bloating reduction).
- Randomized, double-blind, placebo-controlled trial of Ficus carica paste for the management of functional constipation
PubMed ID: 27440682
Fig (high‑fiber) paste RCT reduced abdominal discomfort and improved stool/transit in functional constipation.
- Randomised clinical trial: mixed soluble/insoluble fibre vs. psyllium for chronic constipation
PubMed ID: 27125883
Mixed plum fiber and psyllium both improved bowel frequency and stool form in constipated adults — relieving constipation often reduces bloating (strong relevance to constipation‑related bloating).
- Randomised clinical trial: low-FODMAP rye bread vs. regular rye bread to relieve the symptoms of irritable bowel syndrome
PubMed ID: 27417338
Low‑FODMAP rye (same high fibre) reduced abdominal pain/flatulence and breath hydrogen in IBS patients — direct evidence for reduced bloating.
- Randomized controlled trial of dietary fiber for the prevention of radiation-induced gastrointestinal toxicity during pelvic radiotherapy
PubMed ID: 28679552
High‑fiber advice during pelvic radiotherapy reduced bowel symptom deterioration, consistent with less bloating/gastrointestinal discomfort.
- A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
PubMed ID: 30425247
Low‑gluten / altered cereal‑fiber diet markedly reduced breath hydrogen (a proxy for intestinal gas), implying less bloating.
- Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial
PubMed ID: 31509971
PHGG improved stool form and increased bifidobacteria, implying improved gut comfort and likely reduced bloating in subjects with loose-stool tendency.
- A randomised, placebo-controlled trial in healthy humans of modified cellulose or psyllium evaluating the role of gelation in altering colonic gas production during inulin co-administration
PubMed ID: 41636227
Psyllium reduced early breath hydrogen and delayed oro-caecal transit—evidence of reduced early colonic fermentation/gas (mechanistic link to less bloating).
- Comparison of Low-Gluten Diets Rich in Oats or Rice-A 6-Week Randomized Clinical Trial With Metabolically Challenged Volunteers
PubMed ID: 40331457
Oat‑rich (higher fibre) diet improved bowel habits and GSRS symptoms vs rice; suggests reduced GI discomfort including bloating.
- Mitigating digestive complications and neutropenia in pediatric leukemia through a Persian medicine product of whole wheat-based dietary intervention: a randomized triple-blind placebo-controlled trial
PubMed ID: 39847133
Wheat‑bran product reduced tummy pain and bloating in children on chemotherapy.
- Tolerability and efficacy of an enteral formula containing partially hydrolyzed guar gum in patients following gastrointestinal surgery: A prospective, multicenter, open-label, randomized controlled study
PubMed ID: 41483486
PHGG enteral formula significantly reduced postoperative abdominal distension in subgroup analyses.
- A Randomized, Double-Blind, Placebo-Controlled Trial: Efficacy of Opuntia ficus-indica Prebiotic Supplementation in Subjects with Gut Dysbiosis
PubMed ID: 38474715
Opuntia extract improved GIQLI and GI symptoms vs placebo over 8 weeks, indicating reduced bloating/discomfort.
- Adaptation to tolerate high doses of arabinoxylan is associated with fecal levels of Bifidobacterium longum
PubMed ID: 38860973
Arabinoxylan caused early bloating then adaptation over 4–6 weeks; supports a net effect on bloating tolerance (transient increase then improvement).
- A low FODMAP diet plus traditional dietary advice versus a low-carbohydrate diet versus pharmacological treatment in irritable bowel syndrome (CARIBS): a single-centre, single-blind, randomised controlled trial
PubMed ID: 38643782
Large RCT in IBS showing dietary strategies (low‑FODMAP) produced superior symptom relief including reductions in bloating-related IBS symptoms.
- Blueberries Improve Abdominal Symptoms, Well-Being and Functioning in Patients with Functional Gastrointestinal Disorders
PubMed ID: 37242279
Blueberry RCT in FGID reported increased abdominal symptom relief versus placebo (likely includes bloating).
- Agave tequilana Fructans Versus Psyllium plantago for Functional Constipation : Randomized Double-blind Clinical Trial
PubMed ID: 37389917
Agave fructans improved constipation symptoms and QoL in functional constipation—likely reduced bloating as part of symptom improvement.
- The Effects of Agave Fructans in a Functional Food Consumed by Patients with Irritable Bowel Syndrome with Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 37630717
IBS‑C patients on agave fructans had large improvements in stool and IBS‑QOL, implying reduced bloating and abdominal discomfort.
- Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial
PubMed ID: 37078654
Large constipation RCT improved stool frequency/consistency and microbiota—changes that can reduce bloating though bloating was not a primary endpoint.
- Use of Faecal Transplantation with a Novel Diet for Mild to Moderate Active Ulcerative Colitis: The CRAFT UC Randomised Controlled Trial
PubMed ID: 34514495
Ulcerative‑colitis exclusion diet (which altered fiber) improved clinical GI outcomes; likely reduces bloating in UC patients.
- Two Gold Kiwifruit Daily for Effective Treatment of Constipation in Adults-A Randomized Clinical Trial
PubMed ID: 36235798
Kiwifruit improved constipation symptoms and GI-related domains—plausible reduction in bloating/comfort.
Energy & Fatigue (52)
- Effect of two dietary fibers on satiety and glycemic parameters: a randomized, double-blind, placebo-controlled, exploratory study
PubMed ID: 24886409
Improvements in postprandial glucose/insulin AUC may translate into more sustained energy for some individuals.
- The impact of soluble dietary fibre on gastric emptying, postprandial blood glucose and insulin in patients with type 2 diabetes
PubMed ID: 24901089
By slowing gastric emptying and blunting glucose excursions, oat β‑glucan can contribute to steadier energy availability post‑meal.
- Intensive low-glycaemic-load dietary intervention for the management of glycaemia and serum lipids among women with gestational diabetes: a randomized control trial
PubMed ID: 25222105
Improvements in fasting/postprandial glycemia with a higher‑fiber, low‑GL diet imply more stable energy availability.
- An enriched, cereal-based bread affects appetite ratings and glycemic, insulinemic, and gastrointestinal hormone responses in healthy adults in a randomized, controlled trial
PubMed ID: 25644342
Fiber+protein bread produced lower glucose excursions postprandially, which can support more sustained energy between meals.
- The effects of functional fiber on postprandial glycemia, energy intake, satiety, palatability and gastrointestinal wellbeing: a randomized crossover trial
PubMed ID: 25066659
Functional fibers blunted post-meal glucose peaks which can help avoid rapid energy dips (supports more sustained energy availability).
- A CHO/fibre diet reduces and a MUFA diet increases postprandial lipaemia in type 2 diabetes: no supplementary effects of low-volume physical training
PubMed ID: 24132660
Diet higher in carbohydrate+fiber improved postprandial lipid responses in T2D and may contribute to steadier post-meal energy availability.
- Diet components associated with perceived fatigue in breast cancer survivors
PubMed ID: 22672363
Cross‑sectional study in breast cancer survivors found those consuming ≥25 g/day fiber reported substantially less fatigue, consistent with more sustained energy (associative evidence).
- Low glycemic load experimental diet more satiating than high glycemic load diet
PubMed ID: 22564018
Low‑GL (higher fiber) diet increased satiety and reduced cravings; low‑GL diets can produce more sustained energy between meals.
- NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study
PubMed ID: 21164548
NUTRIOSE improved glycaemic markers and insulin resistance — metabolic stability can translate to more sustained energy.
- Hydroxypropylmethylcellulose and methylcellulose consumption reduce postprandial insulinemia in overweight and obese men and women
PubMed ID: 18203894
Reduced postprandial insulin and blunted glucose peaks suggest more stable energy availability after meals.
- Effect of a viscous fiber bar on postprandial glycemia in subjects with type 2 diabetes
PubMed ID: 17031010
Marked reductions in postprandial glycemic excursions suggest more stable blood glucose and potentially steadier energy.
- Effects of flax fiber on laxation and glycemic response in healthy volunteers
PubMed ID: 16379563
Flax fiber reduced peak glucose and AUC, which can translate to more stable energy between meals.
- Inclusion of guar gum and alginate into a crispy bar improves postprandial glycemia in humans
PubMed ID: 15051842
Reducing postprandial glucose peaks with viscous fibres can translate to more stable energy between meals.
- Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial
PubMed ID: 14744846
Ad libitum high-fiber diet improved weight/fat and likely stabilized energy intake and day-to-day energy levels (indirect).
- Effects of a beverage containing an enzymatically induced-viscosity dietary fiber, with or without fructose, on the postprandial glycemic response to a high glycemic index food in humans
PubMed ID: 12947431
By lowering postprandial glucose peaks and smoothing glycemia, guar gum can support steadier energy release after meals (human evidence on glycemia).
- A flexible, low-glycemic index mexican-style diet in overweight and obese subjects with type 2 diabetes improves metabolic parameters during a 6-week treatment period
PubMed ID: 12832297
Low‑GI/higher‑fiber diet improved glycemic control (A1c) — consistent with steadier energy between meals.
- Consumption of whole grain and legume powder reduces insulin demand, lipid peroxidation, and plasma homocysteine concentrations in patients with coronary artery disease: randomized controlled clinical trial
PubMed ID: 11742886
Improved glycemic responses after higher-fiber whole-grain/legume intake could translate to steadier postprandial energy availability.
- Long-term dietary treatment with increased amounts of fiber-rich low-glycemic index natural foods improves blood glucose control and reduces the number of hypoglycemic events in type 1 diabetic patients
PubMed ID: 11023137
High‑fiber diet in type 1 diabetics reduced glycemic variability and hypoglycemia, which can translate into steadier energy.
- Lipid- and glucose-lowering efficacy of Plantago Psyllium in type II diabetes
PubMed ID: 9747644
Improved fasting glucose control in T2D could translate to steadier energy availability; trial showed improved glycemia.
- Influence of two guar preparations on glycosylated hemoglobin, total cholesterol and triglycerides in patients with diabetes mellitus
PubMed ID: 1335441
Guar fibre reduced long-term glycemic marker (HbA1), suggesting improved glycemic control and more stable energy availability.
- Effects of high-fiber diets enriched with carbohydrate, protein, or unsaturated fat on circulating short chain fatty acids: results from the OmniHeart randomized trial
PubMed ID: 31927581
High-fiber diets altered circulating SCFAs associated with lower insulin/glucose—may support steadier energy between meals.
- Orange Pomace Improves Postprandial Glycemic Responses: An Acute, Randomized, Placebo-Controlled, Double-Blind, Crossover Trial in Overweight Men
PubMed ID: 28208806
High‑fiber pomace slowed glucose fall after peak and reduced insulin AUC, supporting steadier postprandial energy.
- Addition of Orange Pomace to Orange Juice Attenuates the Increases in Peak Glucose and Insulin Concentrations after Sequential Meal Ingestion in Men with Elevated Cardiometabolic Risk
PubMed ID: 27170728
OPF lowered and delayed glucose/insulin peaks which can smooth energy availability after meals.
- Differential Effects of Red Meat/Refined Grain Diet and Dairy/Chicken/Nuts/Whole Grain Diet on Glucose, Insulin and Triglyceride in a Randomized Crossover Study
PubMed ID: 27809219
Lowered postprandial glucose/insulin excursions with wholegrain pattern implies more stable energy availability after meals.
- Effect of Barley on Postprandial Blood Glucose Response and Appetite in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39599684
Reduced postprandial glucose/insulin spikes and greater satiety suggest more stable energy over the postprandial period.
- Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics
PubMed ID: 30046942
Improved next‑meal glucose tolerance and hormonal responses support steadier energy availability.
- Diabetes Therapeutics of Prebiotic Soluble Dietary Fibre and Antioxidant Anthocyanin Supplement in Patients with Type 2 Diabetes: Randomised Placebo-Controlled Clinical Trial
PubMed ID: 40218856
Improved fasting glucose/HbA1c in T2DM implies better glycemic control and potentially steadier energy over time.
- An Anthocyanin-Rich Mixed-Berry Intervention May Improve Insulin Sensitivity in a Randomized Trial of Overweight and Obese Adults
PubMed ID: 31775396
Reduced postprandial insulin AUC with berries suggests slower nutrient absorption and more sustained energy release.
- Gastrointestinal microbiome modulator improves glucose tolerance in overweight and obese subjects: A randomized controlled pilot trial
PubMed ID: 26424589
Inulin+β‑glucan blunted glucose excursion—consistent with steadier energy release.
- Association of dietary fibre with type 2 diabetes risk is modified by transcription factor 7 like 2 genotype in men with impaired fasting glucose: The T2D-GENE study
PubMed ID: 40961511
Higher fiber intake was associated with smaller rises in blood glucose and better glycemic profiles, which can translate into steadier, more sustained energy between meals.
- High hydrostatic pressure processing reduces the glycemic index of fresh mango puree in healthy subjects
PubMed ID: 25797308
Lower and delayed postprandial glucose after higher‑viscosity/structured puree suggests more sustained blood glucose/energy availability.
- Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
PubMed ID: 35300378
Konjac improved glycemic markers (HbA1c) and weight; stable blood sugar supports more sustained energy.
- Dietary Composition, Meal Timing, and Cancer-Related Fatigue: Insights From the Women's Healthy Eating and Living Study
PubMed ID: 38032743
Observational analyses in breast cancer survivors linked higher diet quality (including fiber‑rich foods) to less fatigue and more energy.
- Effect of nutritional promotion intervention on dietary adherence among type II diabetes patients in North Shoa Zone Amhara Region: quasi-experimental study
PubMed ID: 37254151
Improved dietary adherence including fiber in T2D could improve glycemic control and energy stability.
- The role of dietary fiber on preventing gestational diabetes mellitus in an at-risk group of high triglyceride-glucose index women: a randomized controlled trial
PubMed ID: 37737931
Reduced GDM risk and lower postprandial glucose in pregnancy imply improved glycemic stability and potential for steadier energy.
- Tapioca Resistant Maltodextrin as a Carbohydrate Source of Oral Nutrition Supplement (ONS) on Metabolic Indicators: A Clinical Trial
PubMed ID: 35267892
Resistant maltodextrin blunted insulin excursions which can translate to steadier energy availability after meals.
- Increased vegetable intake improves glycaemic control in adults with type 2 diabetes mellitus: a clustered randomised clinical trial among Indonesian white-collar workers
PubMed ID: 35836691
Raw‑vegetable intervention produced large glucose improvements in T2D, likely improving day‑to‑day energy stability.
- Chronic consumption of probiotics, oats, and apples has differential effects on postprandial bile acid profile and cardiometabolic disease risk markers compared with an isocaloric control (cornflakes): a randomized trial
PubMed ID: 36811563
Oats/apples reduced post‑meal insulin and C‑peptide — supporting steadier substrate availability and perceived energy.
- Human clinical trial to assess the effect of consumption of multigrain Indian bread on glycemic regulation in type 2 diabetic participants
PubMed ID: 33006193
Improved glycemic control parameters in T2DM suggest more stable energy metabolism over time (clinical evidence).
- Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults: A Randomized Clinical Trial
PubMed ID: 33252690
High-fiber vegan diet increased post-meal energy expenditure and improved metabolic parameters—consistent with more sustained energetic profile.
- Impact of oat processing on glycaemic and insulinaemic responses in healthy humans: a randomised clinical trial
PubMed ID: 31068229
Lower postprandial glycemic/insulinemic responses with less-processed oats support more stable energy levels after meals.
- Effect of an individualised high-protein, energy-restricted diet on anthropometric and cardio-metabolic parameters in overweight and obese Malaysian adults: a 6-month randomised controlled study
PubMed ID: 30761964
Improved metabolic health and reduced insulin resistance on the higher‑fibre diet can support more stable energy over time.
- A proof-of-concept study to evaluate the efficacy and safety of BTI320 on post-prandial hyperglycaemia in Chinese subjects with pre-diabetes
PubMed ID: 30170579
Reduced post‑meal glucose excursions suggest fewer spikes/crashes and more sustained energy in prediabetics.
- A Plant-Based High-Carbohydrate, Low-Fat Diet in Overweight Individuals in a 16-Week Randomized Clinical Trial: The Role of Carbohydrates
PubMed ID: 30223451
Sustained dietary change (higher fiber) improved metabolic markers and weight, supporting better day-to-day energy regulation over time.
- Postprandial glucose-lowering effect of premeal consumption of protein-enriched, dietary fiber-fortified bar in individuals with type 2 diabetes mellitus or normal glucose tolerance
PubMed ID: 29502350
Premeal fiber-bar reduced postprandial glucose excursions and insulin peaks — mechanistically consistent with more sustained energy between meals.
- Impact of Diets Rich in Whole Grains and Fruits and Vegetables on Cardiovascular Risk Factors in Overweight and Obese Women: A Randomized Clinical Feeding Trial
PubMed ID: 29702040
Whole-grain diet improved glycemic metrics; stabilized glucose can translate to more sustained energy though not directly measured.
- Type-4 Resistant Starch in Substitution for Available Carbohydrate Reduces Postprandial Glycemic Response and Hunger in Acute, Randomized, Double-Blind, Controlled Study
PubMed ID: 29373530
Lowered glycemic response with RS4 could support steadier post-meal energy
- The effectiveness of healthy meals at work on reaction time, mood and dietary intake: a randomised cross-over study in daytime and shift workers at an university hospital
PubMed ID: 28820084
Workplace meal intervention that increased fiber intake reduced fatigue and increased vigour in shift-workers, implying more sustained subjective energy.
- Glycemic Index of a Novel High-Fiber White Rice Variety Developed in India--A Randomized Control Trial Study
PubMed ID: 26741823
High‑fiber white rice had a 23% lower GI—lower glycemic index supports more sustained postprandial energy vs standard white rice (direct GI evidence).
- Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial)
PubMed ID: 27733151
Psyllium improved glycaemic markers, which can contribute to steadier energy availability.
- Short- and Long-Term Effects of Wholegrain Oat Intake on Weight Management and Glucolipid Metabolism in Overweight Type-2 Diabetics: A Randomized Control Trial
PubMed ID: 27618090
Oats produced steadier postprandial glucose and improved HbA1c — physiologic basis for more sustained energy.
- Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial
PubMed ID: 26811130
Pea fiber lowered glucose AUC (smoother glycaemia supports sustained energy).
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