Pine Bark Extract
18 benefits mapped to clinical evidence across supplements.
Dose per serving from products
321 products in our catalogue print how much Pine Bark Extract a serving holds.
Most common: 25 mg to 50 mg, 22% of 321 products.
| Dose per serving | Products |
|---|---|
| 5 mg or less | 10 |
| 5 mg to 10 mg | 26 |
| 10 mg to 25 mg | 55 |
| 25 mg to 50 mg | 71 |
| 50 mg to 100 mg | 64 |
| 100 mg to 250 mg | 69 |
| 250 mg to 500 mg | 25 |
| over 500 mg | 1 |
Dose per serving from research
38 study groups in 32 studies say how much Pine Bark Extract participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 100 mg to 250 mg, 45% of 38 study groups.
| Daily dose | Study groups |
|---|---|
| 25 mg or less | 2 |
| 25 mg to 50 mg | 6 |
| 50 mg to 100 mg | 8 |
| 100 mg to 250 mg | 17 |
| 250 mg to 500 mg | 4 |
| over 500 mg | 1 |
Benefit Evidence
Vasodilation +41% FBF
Blood pressure -7.5 mmHg
Edema/leakage reduced
Research sources
Vascular health (16)
- Effect of a polyphenol-rich dietary supplement containing Pinus massoniana bark extract on blood pressure in healthy adults: A parallel, randomized placebo-controlled trial
PubMed ID: 36280012
Systolic BP reductions (noted in subgroups) support improved vascular function and reduced arterial load.
- The effect of French maritime pine bark extract supplementation on inflammation, nutritional and clinical status in critically ill patients with traumatic brain injury: A randomized controlled trial
PubMed ID: 34382717
Large anti‑inflammatory effects and improved clinical/ survival outcomes suggest systemic vascular benefit in critically ill patients.
- PYCNOGENOL in chronic venous insufficiency
PubMed ID: 11081989
Symptomatic and hemodynamic improvements in chronic venous insufficiency reflect improved venous vascular function.
- Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study
PubMed ID: 16708123
Superior improvements in microcirculation, capillary filtration and tissue oxygenation vs comparator in CVI.
- Effect of Pycnogenol on the Healing of Venous Ulcers
PubMed ID: 27521821
Enhanced venous ulcer healing and reduced limb circumference indicate benefit to local vascular/venous health.
- Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II
PubMed ID: 15363656
Adjunctive Pycnogenol in T2D lowered endothelin-1 and plasma glucose, supporting endothelial/vascular benefit.
- Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency
PubMed ID: 11933130
CVI study reduced leg swelling and LDL — vascular improvements noted.
- Pycnogenol in chronic venous insufficiency
PubMed ID: 10844161
Symptomatic improvement in venous insufficiency with reduced edema/pain.
- Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol
PubMed ID: 15497024
Randomized trial showed marked reduction in flight‑associated thrombotic events — strong vascular benefit.
- Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation
PubMed ID: 19083426
Metabolic improvements and ACE‑sparing effect support vascular health in T2DM patients.
- Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy
PubMed ID: 19916788
Improved retinal blood flow and reduced retinal edema in diabetic retinopathy.
- Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled study
PubMed ID: 20579863
Improved microcirculation and clinical CVI signs in RCT; additive benefit with compression.
- Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients
PubMed ID: 14659974
Favorable shifts in endothelin-1 and vasodilatory prostaglandin in mildly hypertensive patients reflect endothelial benefit.
- Cellular pharmacodynamic effects of Pycnogenol® in patients with severe osteoarthritis: a randomized controlled pilot study
PubMed ID: 29246219
Reductions in cartilage‑degrading enzymes and ADAMTS‑5 suggest local joint‑vascular matrix benefits; indirect vascular relevance.
- Impact of a Dietary Supplementation with French Maritime Pine Bark Extract Pycnogenol(®) on Salivary and Serum Inflammatory Biomarkers During Non-Surgical Periodontal Therapy-A Randomized Placebo-Controlled Double-Blind Trial
PubMed ID: 40362854
Lowered inflammatory markers and evidence of systemic metabolite uptake support vascular anti‑inflammatory effects.
- Effect of French maritime pine bark extract supplementation on metabolic status and serum vascular cell adhesion molecule-1 levels in patients with type 2 diabetes and microalbuminuria
PubMed ID: 33610726
Direct evidence of improved endothelial health (VCAM‑1 reduction), reduced microalbuminuria and metabolic improvements in T2D patients.
Blood circulation (14)
- Improvement of erectile function with Prelox: a randomized, double-blind, placebo-controlled, crossover trial
PubMed ID: 17703218
Combination product improved erectile function and e-NOS measures, indicating vascular effects.
- Effect of a polyphenol-rich dietary supplement containing Pinus massoniana bark extract on blood pressure in healthy adults: A parallel, randomized placebo-controlled trial
PubMed ID: 36280012
Systolic and some diastolic BP reductions (noted in subgroups) imply improved hemodynamic load and circulation.
- Effect of French maritime pine bark extract supplementation on metabolic status and serum vascular cell adhesion molecule-1 levels in patients with type 2 diabetes and microalbuminuria
PubMed ID: 33610726
Improved endothelial marker (VCAM‑1) and reduced microalbuminuria indicate better endothelial/microvascular health.
- Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled study
PubMed ID: 20579863
RCT in CVI showed marked decreases in ankle swelling and improved microcirculatory flux; additive with compression.
- Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy
PubMed ID: 19916788
Increased retinal blood flow and reduced retinal edema in early diabetic retinopathy.
- Diabetic ulcers: microcirculatory improvement and faster healing with pycnogenol
PubMed ID: 16959685
Improved local blood flow alongside faster diabetic foot ulcer healing.
- Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol
PubMed ID: 15497024
Reduced flight‑associated thrombotic events and edema — clinically meaningful circulation benefit for travelers.
- Treatment of vascular retinopathies with Pycnogenol
PubMed ID: 11351356
Reduced retinal vascular leakage and improved vascularization in retinopathies.
- Pycnogenol in chronic venous insufficiency
PubMed ID: 10844161
Double‑blind trial: marked reductions in leg swelling, pain and heaviness in CVI.
- Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency
PubMed ID: 11933130
Open controlled CVI study reduced limb circumference and symptoms.
- Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study
PubMed ID: 16708123
Faster and larger improvements in microcirculation, capillary filtration and tissue oxygenation in severe CVI.
- PYCNOGENOL in chronic venous insufficiency
PubMed ID: 11081989
Improved leg heaviness, edema and reduced venous pressure in chronic venous insufficiency.
- Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients
PubMed ID: 14659974
Favorable endothelial biomarker changes in mildly hypertensive patients suggesting improved circulation.
- Improvement of erectile function by a combination of French maritime pine bark and roburins with aminoacids
PubMed ID: 25664962
Erectile function restoration in combination product implies improved regional circulation (but multi-ingredient).
Healthy aging (12)
- Effects of French maritime pine bark extract (Oligopin®) supplementation on bone remodeling markers in postmenopausal osteopenic women: A randomized clinical trial
PubMed ID: 30907034
RCT in osteopenic postmenopausal women showed favorable bone-turnover marker shifts (surrogate of aging bone health).
- Impact of a Dietary Supplementation with French Maritime Pine Bark Extract Pycnogenol(®) on Salivary and Serum Inflammatory Biomarkers During Non-Surgical Periodontal Therapy-A Randomized Placebo-Controlled Double-Blind Trial
PubMed ID: 40362854
Systemic polyphenol uptake and reduced inflammatory markers support mechanisms linked to healthy aging.
- Effect of a polyphenol-rich dietary supplement containing Pinus massoniana bark extract on blood pressure in healthy adults: A parallel, randomized placebo-controlled trial
PubMed ID: 36280012
Lowering systolic BP in at‑risk individuals contributes to cardiovascular risk reduction across aging.
- Effect of French maritime pine bark extract supplementation on metabolic status and serum vascular cell adhesion molecule-1 levels in patients with type 2 diabetes and microalbuminuria
PubMed ID: 33610726
Improved glycemic control, endothelial markers and abdominal measures in T2D support metabolic and vascular aspects of healthy aging.
- French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial
PubMed ID: 32841433
Improvement in skin hyperpigmentation (melasma) is relevant to skin aging/vitality.
- Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women: a randomized, double-blind, placebo-controlled trial
PubMed ID: 23447917
Perimenopausal RCT reduced climacteric symptoms (vasomotor/insomnia) — supports wellbeing with aging.
- A randomised, double-blind, placebo-controlled trial on the effect of Pycnogenol on the climacteric syndrome in peri-menopausal women
PubMed ID: 17653885
Improved menopausal symptoms and antioxidative status in peri‑menopausal women.
- Oral administration of French maritime pine bark extract (Flavangenol(®)) improves clinical symptoms in photoaged facial skin
PubMed ID: 22956863
Improved photoaged skin appearance and epidermal turnover — topical/systemic aging relevance.
- Oral Pycnogenol® Intake Benefits the Skin in Urban Chinese Outdoor Workers: A Randomized, Placebo-Controlled, Double-Blind, and Crossover Intervention Study
PubMed ID: 33789311
Prevented seasonal skin deterioration and improved elasticity in outdoor workers—supports age-related skin resilience.
- Oligopin® Supplementation Mitigates Oxidative Stress in Postmenopausal Women with Osteopenia: A Randomized, Double-blind, Placebo-Controlled Trial
PubMed ID: 33250314
Antioxidant improvements and beneficial bone marker changes in postmenopausal women support healthy aging.
- Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women
PubMed ID: 15764035
Multi-ingredient product improved skin elasticity/roughness in older women (aging-relevant outcomes).
- A randomized, double-blind, placebo-controlled study on the clinical efficacy of oral treatment with DermaVite on ageing symptoms of the skin
PubMed ID: 15938587
Multi-ingredient oral supplement including pine bark improved objective signs of skin aging.
Swelling relief (10)
- Impact of a Dietary Supplementation with French Maritime Pine Bark Extract Pycnogenol(®) on Salivary and Serum Inflammatory Biomarkers During Non-Surgical Periodontal Therapy-A Randomized Placebo-Controlled Double-Blind Trial
PubMed ID: 40362854
Decreased salivary MMP‑8 and IL‑6 during periodontal therapy suggest reduced local swelling/inflammation.
- Pycnogenol treatment of acute hemorrhoidal episodes
PubMed ID: 20041428
Hemorrhoid symptoms including swelling improved rapidly with oral/topical Pycnogenol.
- Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol
PubMed ID: 15497024
Edema score improved in flight study (reduced edema on long flights).
- Pycnogenol in chronic venous insufficiency
PubMed ID: 10844161
Double‑blind trial: marked reductions in subcutaneous leg edema in CVI patients.
- Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency
PubMed ID: 11933130
Significant decrease in limb circumference and improvement of subjective swelling in CVI.
- Effect of Pycnogenol on the Healing of Venous Ulcers
PubMed ID: 27521821
Venous ulcer trial reported significant decreases in limb circumference (swelling) over 90 days.
- Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study
PubMed ID: 16708123
Showed faster reduction in edema and capillary filtration vs comparator in severe CVI.
- PYCNOGENOL in chronic venous insufficiency
PubMed ID: 11081989
CVI trial reported clinically meaningful reductions in leg edema and capillary leakage.
- The effect of French maritime pine bark extract supplementation on inflammation, nutritional and clinical status in critically ill patients with traumatic brain injury: A randomized controlled trial
PubMed ID: 34382717
Substantial reductions in systemic inflammatory cytokines (IL‑6, IL‑1β, CRP) are consistent with decreased inflammatory swelling.
- Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled study
PubMed ID: 20579863
Ankle swelling significantly reduced in CVI RCT; combination with compression most effective.
Antioxidant (9)
- Circulating levels of reactive oxygen species in patients with nonproliferative diabetic retinopathy and the influence of antioxidant supplementation: 6-month follow-up
PubMed ID: 25686055
Combination supplement including Pycnogenol reduced ROS markers in diabetic retinopathy patients.
- Impact of a Dietary Supplementation with French Maritime Pine Bark Extract Pycnogenol(®) on Salivary and Serum Inflammatory Biomarkers During Non-Surgical Periodontal Therapy-A Randomized Placebo-Controlled Double-Blind Trial
PubMed ID: 40362854
Increased salivary polyphenol metabolite levels and decreased inflammatory markers indicate systemic antioxidant exposure and activity.
- Effect of French maritime pine bark extract supplementation on metabolic status and serum vascular cell adhesion molecule-1 levels in patients with type 2 diabetes and microalbuminuria
PubMed ID: 33610726
Improvements in endothelial and metabolic markers in T2D are consistent with antioxidant/polyphenol effects.
- The effect of French maritime pine bark extract supplementation on inflammation, nutritional and clinical status in critically ill patients with traumatic brain injury: A randomized controlled trial
PubMed ID: 34382717
Marked reductions in pro‑inflammatory cytokines (IL‑6, IL‑1β, CRP) in critically ill patients, consistent with antioxidant/anti‑inflammatory activity.
- French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial
PubMed ID: 32841433
Oral Pycnogenol plus topical therapy improved melasma severity; skin pigment improvement is plausibly mediated by antioxidant mechanisms.
- Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol
PubMed ID: 19017467
Decreased plasma free radicals and improved antioxidant markers in OA subset.
- A randomised, double-blind, placebo-controlled trial on the effect of Pycnogenol on the climacteric syndrome in peri-menopausal women
PubMed ID: 17653885
Increased antioxidative status in peri‑menopausal trial.
- A controlled study shows daily intake of 50 mg of French Pine Bark Extract (Pycnogenol®) lowers plasma reactive oxygen metabolites in healthy smokers
PubMed ID: 24008606
Randomized trial showed large reductions in oxidative markers and increased antioxidant potential in smokers.
- Oligopin® Supplementation Mitigates Oxidative Stress in Postmenopausal Women with Osteopenia: A Randomized, Double-blind, Placebo-Controlled Trial
PubMed ID: 33250314
RCT showed multiple consistent improvements in TAC, thiols, MnSOD/catalase activity and reduced protein carbonyls.
Inflammation (9)
- Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol
PubMed ID: 19017467
Large decreases in CRP and fibrinogen in OA subgroup — strong anti‑inflammatory signal.
- Impact of a Dietary Supplementation with French Maritime Pine Bark Extract Pycnogenol(®) on Salivary and Serum Inflammatory Biomarkers During Non-Surgical Periodontal Therapy-A Randomized Placebo-Controlled Double-Blind Trial
PubMed ID: 40362854
Significant decreases in salivary MMP‑8 and a between‑group difference in serum IL‑6 during periodontal therapy.
- Effect of French maritime pine bark extract supplementation on metabolic status and serum vascular cell adhesion molecule-1 levels in patients with type 2 diabetes and microalbuminuria
PubMed ID: 33610726
Reductions in VCAM‑1 and urinary albumin suggest lowered endothelial inflammation in T2D patients.
- The effect of French maritime pine bark extract supplementation on inflammation, nutritional and clinical status in critically ill patients with traumatic brain injury: A randomized controlled trial
PubMed ID: 34382717
Strong RCT evidence of substantial reductions in IL‑6, IL‑1β and CRP in TBI patients—clear anti‑inflammatory effect.
- Cellular pharmacodynamic effects of Pycnogenol® in patients with severe osteoarthritis: a randomized controlled pilot study
PubMed ID: 29246219
Reduced expression of IL1B and MMPs in OA cartilage — mechanistic anti‑inflammatory effect.
- Pycnogenol treatment of acute hemorrhoidal episodes
PubMed ID: 20041428
Hemorrhoid symptoms and bleeding resolved quickly — consistent with anti‑inflammatory/hemostatic effect.
- French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
PubMed ID: 18567279
Dysmenorrhea trial showed reduced pain and analgesic need consistent with anti‑inflammatory/analgesic effect.
- Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis
PubMed ID: 18570266
Knee OA RCT reduced symptoms and analgesic use; inflammation likely mediator.
- Pycnogenol as an adjunct in the management of childhood asthma
PubMed ID: 15641632
Children with asthma had lowered inflammatory leukotrienes and symptom improvement.
Heart health (5)
- A randomised, double-blind, placebo-controlled trial on the effect of Pycnogenol on the climacteric syndrome in peri-menopausal women
PubMed ID: 17653885
Improved antioxidant status and favorable LDL/HDL ratio in peri‑menopausal women.
- Effect of a polyphenol-rich dietary supplement containing Pinus massoniana bark extract on blood pressure in healthy adults: A parallel, randomized placebo-controlled trial
PubMed ID: 36280012
Modest, clinically relevant systolic BP reductions (especially in normal‑high, nonmedicated subgroup), which supports cardiovascular load reduction.
- Effect of French maritime pine bark extract supplementation on metabolic status and serum vascular cell adhesion molecule-1 levels in patients with type 2 diabetes and microalbuminuria
PubMed ID: 33610726
Improved endothelial marker (VCAM‑1), reduced microalbuminuria and metabolic measures in T2D—supports vascular/heart health.
- Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation
PubMed ID: 19083426
Lowered LDL and allowed antihypertensive dose reduction in diabetics — direct cardiometabolic benefit.
- Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency
PubMed ID: 11933130
LDL decreased in CVI trial — modest cardiometabolic relevance.
Joint comfort (5)
- Treatment of osteoarthritis with Pycnogenol. The SVOS (San Valentino Osteo-arthrosis Study). Evaluation of signs, symptoms, physical performance and vascular aspects
PubMed ID: 18386255
Large double‑blind RCT: marked WOMAC improvement, walking distance gain and reduced analgesic use.
- Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol
PubMed ID: 19017467
OA subset: reductions in oxidative/inflammatory markers that may mediate symptom relief.
- Cellular pharmacodynamic effects of Pycnogenol® in patients with severe osteoarthritis: a randomized controlled pilot study
PubMed ID: 29246219
Pilot RCT showed downregulation of MMPs/IL1B and reduced ADAMTS‑5 and CTX‑II — mechanistic chondroprotective evidence.
- Distribution of Constituents and Metabolites of Maritime Pine Bark Extract (Pycnogenol(®)) into Serum, Blood Cells, and Synovial Fluid of Patients with Severe Osteoarthritis: A Randomized Controlled Trial
PubMed ID: 28452960
Demonstrated Pycnogenol polyphenols and metabolites reach synovial fluid — supports joint effects.
- Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis
PubMed ID: 18570266
150 mg/day for 3 months reduced OA symptom scores and pain medication use.
Skin health (5)
- French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial
PubMed ID: 32841433
Double‑blind RCT where oral Pycnogenol plus topical therapy produced substantially larger reductions in melasma severity and higher patient improvement rates.
- A randomized, double-blind, placebo-controlled study on the clinical efficacy of oral treatment with DermaVite on ageing symptoms of the skin
PubMed ID: 15938587
Multi-ingredient oral supplement including pine bark improved skin elasticity/thickness and reduced wrinkles.
- Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women
PubMed ID: 15764035
Placebo-controlled trial in older women showed improved skin elasticity and reduced roughness with a multi-ingredient supplement.
- Oral Pycnogenol® Intake Benefits the Skin in Urban Chinese Outdoor Workers: A Randomized, Placebo-Controlled, Double-Blind, and Crossover Intervention Study
PubMed ID: 33789311
12-week crossover showed protection of skin hydration, TEWL and improved elasticity in outdoor workers.
- Oral administration of French maritime pine bark extract (Flavangenol(®)) improves clinical symptoms in photoaged facial skin
PubMed ID: 22956863
Oral Pycnogenol improved age spots, photoaging scores and epidermal turnover in randomized study.
Skin repair (4)
- Pycnogenol treatment of acute hemorrhoidal episodes
PubMed ID: 20041428
Oral/topical Pycnogenol rapidly stopped hemorrhoidal bleeding and improved symptoms.
- Effect of Pycnogenol on the Healing of Venous Ulcers
PubMed ID: 27521821
Small randomized trial found Pycnogenol aided venous ulcer healing and reduced limb circumference over 90 days.
- An evaluation of Vitamin E and Pycnogenol in children suffering from oral mucositis during cancer chemotherapy
PubMed ID: 23078515
Topical Pycnogenol reduced chemotherapy‑related oral mucositis severity in children (not effective for most severe lesions).
- Diabetic ulcers: microcirculatory improvement and faster healing with pycnogenol
PubMed ID: 16959685
Controlled trial showed much higher diabetic foot ulcer healing rates with oral and/or topical Pycnogenol.
Eye health (4)
- A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms
PubMed ID: 20549654
When started pre‑season, Pycnogenol reduced eye symptoms in pollen allergy cohort.
- Circulating levels of reactive oxygen species in patients with nonproliferative diabetic retinopathy and the influence of antioxidant supplementation: 6-month follow-up
PubMed ID: 25686055
Supplement with Pycnogenol reduced oxidative stress markers and slightly decreased central macular thickness in NPDR patients.
- Treatment of vascular retinopathies with Pycnogenol
PubMed ID: 11351356
Reduced retinal vascular leakage and improved visual function in vascular retinopathies.
- Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy
PubMed ID: 19916788
Early diabetic retinopathy: reduced retinal swelling, increased retinal blood flow and improved visual acuity.
Blood sugar (4)
- Effect of French maritime pine bark extract supplementation on metabolic status and serum vascular cell adhesion molecule-1 levels in patients with type 2 diabetes and microalbuminuria
PubMed ID: 33610726
Double‑blind RCT showing significant HbA1c reduction versus placebo and other metabolic improvements in T2D patients.
- Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation
PubMed ID: 19083426
12‑week RCT in T2DM: large reductions in fasting glucose and HbA1c vs placebo.
- Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II
PubMed ID: 15363656
Adjunctive Pycnogenol in T2D lowered plasma glucose over 12 weeks (and transient HbA1c change).
- The Hypoglycaemic Effects of the New Zealand Pine Bark Extract on Sucrose Uptake and Glycaemic Responses in Healthy Adults-A Single-Blind, Randomised, Placebo-Controlled, Crossover Trial
PubMed ID: 40732901
Acute crossover trial showed a statistically significant reduction in post-sucrose glucose iAUC at 400 mg.
Oral health (3)
- PYCNOGENOL chewing gum minimizes gingival bleeding and plaque formation
PubMed ID: 12222660
Chewing gum with Pycnogenol lowered gingival bleeding and prevented plaque increase in a double‑blind study.
- An evaluation of Vitamin E and Pycnogenol in children suffering from oral mucositis during cancer chemotherapy
PubMed ID: 23078515
Topical Pycnogenol reduced chemo‑related oral mucositis severity in children (not for most severe lesions).
- Impact of a Dietary Supplementation with French Maritime Pine Bark Extract Pycnogenol(®) on Salivary and Serum Inflammatory Biomarkers During Non-Surgical Periodontal Therapy-A Randomized Placebo-Controlled Double-Blind Trial
PubMed ID: 40362854
Well‑powered RCT during non‑surgical periodontal therapy showed increased salivary polyphenol metabolite and significant reductions in salivary MMP‑8 and serum IL‑6.
Allergy relief (2)
- Pycnogenol as an adjunct in the management of childhood asthma
PubMed ID: 15641632
Improved asthma symptoms and decreased leukotrienes in children indicate allergy/airway symptom relief.
- A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms
PubMed ID: 20549654
Small randomized study: reduced eye and nasal allergy symptoms when started several weeks pre‑season.
Blood pressure (2)
- Effect of a polyphenol-rich dietary supplement containing Pinus massoniana bark extract on blood pressure in healthy adults: A parallel, randomized placebo-controlled trial
PubMed ID: 36280012
RCT showing modest but clinically meaningful reductions in systolic BP (particularly in normal‑high, nonmedicated participants).
- Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation
PubMed ID: 19083426
Allowed reduction in antihypertensive (ACE inhibitor) dose in treated diabetics — clinically relevant BP effect.
Energy & Fatigue (1)
- Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women: a randomized, double-blind, placebo-controlled trial
PubMed ID: 23447917
Reduced insomnia and vasomotor symptoms in perimenopausal women — likely reduced fatigue/ tiredness.
Endurance (1)
- Treatment of osteoarthritis with Pycnogenol. The SVOS (San Valentino Osteo-arthrosis Study). Evaluation of signs, symptoms, physical performance and vascular aspects
PubMed ID: 18386255
Marked increase in walking distance in OA patients suggests improved endurance/function.
Focus & concentration (1)
- Treatment of ADHD with French maritime pine bark extract, Pycnogenol
PubMed ID: 16699814
Pediatric RCT showed improved attention and reduced hyperactivity on 1 mg/kg/day.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Pine Bark Extract
Search all537 products whose verified label declares Pine Bark Extract — not every bottle that mentions it in a title.