Krill Oil
15 benefits mapped to clinical evidence across supplements.
Dose per serving from products
394 products in our catalogue print how much Krill Oil a serving holds.
Most common: 500 mg to 1 g, 41% of 394 products.
| Dose per serving | Products |
|---|---|
| 250 mg or less | 8 |
| 250 mg to 500 mg | 151 |
| 500 mg to 1 g | 160 |
| 1 g to 2.5 g | 75 |
Dose per serving from research
31 study groups in 25 studies say how much Krill Oil participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 g to 5 g, 32% of 31 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mg to 500 mg | 4 |
| 500 mg to 1 g | 6 |
| 1 g to 2.5 g | 8 |
| 2.5 g to 5 g | 10 |
| 5 g to 10 g | 3 |
Benefit Evidence
Research sources
Inflammation (6)
- Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial
PubMed ID: 35880828
Knee OA RCT showed modest improvements in pain/stiffness/function with krill oil and increased Omegaâ3 Indexâconsistent with antiâinflammatory effects.
- Krill Oil Improves Mild Knee Joint Pain: A Randomized Control Trial
PubMed ID: 27701428
Knee symptom improvements accompanied by increases in EPA/AA ratio and reductions in AA, consistent with reduced inflammatory tone.
- Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms
PubMed ID: 17353582
Rapid and significant CRP reductions and symptomatic improvement in chronic inflammation indicate a strong anti-inflammatory signal.
- Correction of omega-3 fatty acid deficiency and improvement in disease activity in patients with systemic lupus erythematosus treated with krill oil concentrate: a multicentre, randomised, double-blind, placebo-controlled trial
PubMed ID: 39009356
In SLE patients krill oil corrected omega-3 status and produced transient reductions in disease activity â direct inflammatory disease evidence.
- A Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Two Forms of Omega-3 Supplements for Treating Dry Eye Disease
PubMed ID: 27817918
Krill oil reduced tear ILâ17A in dryâeye patients, demonstrating a local antiâinflammatory effect.
- Benefits of Krill Oil Supplementation During Alternate-Day Fasting in Adults With Overweight and Obesity: A Randomized Trial
PubMed ID: 40671417
During alternateâday fasting krill supplementation was associated with larger reductions in inflammatory markers (TNFâÎą and CRP) vs placebo.
Heart health (4)
- Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia
PubMed ID: 15656713
Older randomized study reported improvements in total cholesterol, triglycerides and glucose with Neptune krill oil vs fish oil/placeboâsupports cardiometabolic benefit (study limitations noted).
- Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels
PubMed ID: 24461313
12âweek RCT in borderline/high TG adults: modest triglyceride lowering (~10%) without LDL increaseâclinically relevant to heart health.
- Effectiveness of a Novel Ď-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia: A Randomized Clinical Trial
PubMed ID: 34989797
Modest but consistent triglyceride and non-HDL reductions in adults with very high triglycerides â direct cardiac risk biomarker benefit.
- A Single-dose, Comparative Bioavailability Study of a Formulation containing OM3 as Phospholipid and Free Fatty Acid to an Ethyl Ester Formulation in the Fasting and Fed States
PubMed ID: 30799231
Krillâtype PL/FFA formulation provided much higher EPA+DHA exposure than ethylâester formulations, increasing potential for cardiovascular effect at lower doses.
Blood circulation (4)
- A Single-dose, Comparative Bioavailability Study of a Formulation containing OM3 as Phospholipid and Free Fatty Acid to an Ethyl Ester Formulation in the Fasting and Fed States
PubMed ID: 30799231
Pharmacokinetic work shows PL/FFA (krillâtype) delivered much higher EPA+DHA exposure with little food effectâsupports reliably increasing circulatory omegaâ3 availability.
- Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels
PubMed ID: 24461313
Large RCT in adults with borderline/high TG: pooled krill groups had modest (~10%) triglyceride lowering without LDL riseâbeneficial circulatory/lipid effect.
- Evaluation of OM3-PL/FFA Pharmacokinetics After Single and Multiple Oral Doses in Healthy Volunteers
PubMed ID: 31679821
Phase I PK: OM3âPL/FFA (krillâtype) produced doseâproportional exposure with minimal meal effectâpractical circulatory dosing advantage.
- Effectiveness of a Novel Ď-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia: A Randomized Clinical Trial
PubMed ID: 34989797
In adults with very high triglycerides krill-derived omega-3 modestly lowered triglycerides and non-HDL-C â beneficial for circulation/vascular risk.
Joint comfort (4)
- Krill Oil Improves Mild Knee Joint Pain: A Randomized Control Trial
PubMed ID: 27701428
Randomized trial in adults with mild knee pain showed improved knee symptom scores and range of motion after krill oil.
- A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of a Krill Oil, Astaxanthin, and Oral Hyaluronic Acid Complex on Joint Health in People with Mild Osteoarthritis
PubMed ID: 37686801
12âweek randomized trial of a krillâoil + astaxanthin + HA complex improved joint pain/function vs placebo, but multiple actives limit attribution to krill oil alone.
- Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms
PubMed ID: 17353582
Reported rapid reductions in CRP and improvements in arthritis symptom scores â direct evidence for joint symptom relief.
- Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial
PubMed ID: 35880828
Large 6âmonth RCT: krill oil raised Omegaâ3 Index and produced modest but statistically significant reductions in knee pain and improved function.
Metabolism (3)
- The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial
PubMed ID: 40118278
Krill oil reduced HbA1c and triglycerides in MDD trial â supports metabolic improvements.
- Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia
PubMed ID: 15656713
Older randomized trial reported improvements in lipids and glucose with krill oil in hyperlipidemic patientsâsupports metabolic effects (study quality concerns).
- Effectiveness of a Novel Ď-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia: A Randomized Clinical Trial
PubMed ID: 34989797
Lowered triglycerides and non-HDL-C in people with very high triglycerides â meaningful metabolic effect.
Healthy aging (3)
- Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers
PubMed ID: 24098072
Elderly men had improved prefrontal oxyhemoglobin signals and shorter P300 latency with krill oilâphysiological markers relevant to aging brain function.
- Do the effects of krill oil supplementation on skeletal muscle function and size in older adults differ by sex, age or BMI: A secondary analysis of a randomised controlled trial
PubMed ID: 41344001
Secondary analysis confirmed consistent muscle/strength benefits across sex, age and BMI â reinforces aging-related benefit.
- The effect of krill oil supplementation on skeletal muscle function and size in older adults: A randomised controlled trial
PubMed ID: 35504165
Randomized trial in older adults showed clinically meaningful increases in leg strength, grip strength and thigh muscle size â strong healthy-aging signal.
Immune support (3)
- The Effect of Krill Oil Supplementation on Exercise Performance and Markers of Immune Function
PubMed ID: 26407095
Krill oil increased erythrocyte omegaâ3s and enhanced some postâexercise immune responses (NK cytotoxicity, PBMC ILâ2) vs placebo.
- Correction of omega-3 fatty acid deficiency and improvement in disease activity in patients with systemic lupus erythematosus treated with krill oil concentrate: a multicentre, randomised, double-blind, placebo-controlled trial
PubMed ID: 39009356
In lupus patients krill oil rapidly corrected omega-3 levels and produced a transient decrease in disease activity â direct immune-disease signal.
- Krill-Oil-Dependent Increases in HS-Omega-3 Index, Plasma Choline and Antioxidant Capacity in Well-Conditioned Power Training Athletes
PubMed ID: 34959789
Trend to less exerciseâinduced antioxidant loss after krill oil suggests potential immune/oxidativeâstress support in athletes.
Illness recovery (3)
- The Effect of Krill Oil Supplementation on Exercise Performance and Markers of Immune Function
PubMed ID: 26407095
Krill increased erythrocyte omegaâ3s and enhanced some exerciseârecovery immune markers (NK cell cytotoxicity, ILâ2) though performance unchanged.
- Krill-Oil-Dependent Increases in HS-Omega-3 Index, Plasma Choline and Antioxidant Capacity in Well-Conditioned Power Training Athletes
PubMed ID: 34959789
In athletes krill oil improved Omegaâ3 status and increased plasma choline after exercise with trends toward preserved antioxidant capacityâsupports recovery.
- Benefits of Krill Oil Supplementation During Alternate-Day Fasting in Adults With Overweight and Obesity: A Randomized Trial
PubMed ID: 40671417
During alternateâday fasting, krill oil attenuated FFM and strength loss and improved chairârise time with larger reductions in inflammatory markersâmeaningful recovery/functional benefit.
Cholesterol (2)
- Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia
PubMed ID: 15656713
Trial reported reductions in total cholesterol, triglycerides and LDL and increases in HDL vs fish oil/placeboâsupports cholesterol modulation (older study).
- Effectiveness of a Novel Ď-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia: A Randomized Clinical Trial
PubMed ID: 34989797
Demonstrated reductions in triglycerides and modest non-HDL-C lowering â direct lipid/cholesterol balance evidence.
Focus & concentration (2)
- Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers
PubMed ID: 24098072
Elderly men had improved prefrontal oxyhemoglobin and reduced P300 latency after 12 weeks of krill oilâphysiological markers of improved brain processing.
- Association between Blood Omega-3 Index and Cognition in Typically Developing Dutch Adolescents
PubMed ID: 26729157
Observational association between higher omega-3 index and slightly faster information processing and fewer attention errors supports a potential focus benefit.
Mood balance (2)
- Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea
PubMed ID: 12777162
Neptune krill oil improved premenstrual emotional symptoms vs fish oil, indicating mood benefits in PMS context.
- The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial
PubMed ID: 40118278
Randomized trial in major depressive disorder showed krill oil reduced depression scores versus placebo.
Energy & Fatigue (1)
- The effect of krill oil supplementation on skeletal muscle function and size in older adults: A randomised controlled trial
PubMed ID: 35504165
In older adults krill oil increased leg strength and grip â plausible indirect evidence for improved functional energy/endurance.
Skin health (1)
- Krill oil supplementation improves transepidermal water loss, hydration and elasticity of the skin in healthy adults: Results from two randomized, double-blind, placebo-controlled, dose-finding pilot studies
PubMed ID: 39169540
Two randomized pilot trials showed dose-responsive reductions in TEWL and increases in hydration and elasticity with krill oil.
Menstrual comfort (1)
- Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea
PubMed ID: 12777162
Neptune krill oil improved menstrual pain, reduced premenstrual emotional symptoms, and lowered analgesic use versus fish oil in a randomized trial.
Eye health (1)
- A Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Two Forms of Omega-3 Supplements for Treating Dry Eye Disease
PubMed ID: 27817918
Randomized trial in dry eye: krill oil (and fish oil) substantially improved tear osmolarity and tear stability and krill reduced symptoms and tear ILâ17Aâstrong evidence for ocular surface benefit.
Similar by evidence
Supplements the same benefits carry qualifying findings for â a fact about the evidence graph, not a recommendation to swap.
Products with Krill Oil
Search all439 products whose verified label declares Krill Oil â not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet â this is what the field is asking, not what it found.