Resveratrol
19 benefits mapped to clinical evidence across supplements.
Dose per serving from products
1,584 products in our catalogue print how much Resveratrol a serving holds.
Most common: 100 mg to 250 mg, 23% of 1,584 products.
| Dose per serving | Products |
|---|---|
| 2.5 mg or less | 73 |
| 2.5 mg to 5 mg | 69 |
| 5 mg to 10 mg | 152 |
| 10 mg to 25 mg | 155 |
| 25 mg to 50 mg | 269 |
| 50 mg to 100 mg | 280 |
| 100 mg to 250 mg | 366 |
| 250 mg to 500 mg | 143 |
| over 500 mg | 77 |
Dose per serving from research
136 study groups in 110 studies say how much Resveratrol participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 29% of 136 study groups.
| Daily dose | Study groups |
|---|---|
| 10 mg or less | 6 |
| 10 mg to 25 mg | 4 |
| 25 mg to 50 mg | 10 |
| 50 mg to 100 mg | 16 |
| 100 mg to 250 mg | 32 |
| 250 mg to 500 mg | 40 |
| 500 mg to 1 g | 23 |
| over 1 g | 5 |
Commonly used together
33 of 139 study groups took Resveratrol with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Epigallocatechin Gallate | 7 |
| Vitamin D | 5 |
| Soy Isoflavones | 3 |
Benefit Evidence
Antioxidant boost, GSH +40%
Inflammation/oxidative damage down
Cell function up
Research sources
Inflammation (30)
- Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease
PubMed ID: 25311610
12-week 500 mg/day trial in NAFLD reduced inflammatory cytokines and NF-ÎșB activity vs placebo.
- Antioxidant Activity with Increased Endogenous Levels of Vitamin C, E and A Following Dietary Supplementation with a Combination of Glutathione and Resveratrol Precursors
PubMed ID: 33105552
Polydatin + precursors lowered urinary neopterin by ~30% and improved antioxidant vitamins, indicating anti-inflammatory effects.
- Resveratrol plus carboxymethyl-ÎČ-glucan reduces nasal symptoms in children with pollen-induced allergic rhinitis
PubMed ID: 24983742
Intranasal resveratrol+ÎČâglucan significantly reduced nasal inflammatory symptoms in allergic rhinitis (clinical antiâinflammatory effect).
- Effects of resveratrol on inflammatory cytokines in COVID-19 patients: a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 40301181
COVID RCT produced statistically significant reductions in CRP, ILâ1ÎČ and TNFâαâstrong short-term systemic anti-inflammatory effect.
- Impact of systemic resveratrol on non-surgical periodontal treatment of smokers: A 12-month randomized clinical trial
PubMed ID: 40884630
Smokers with periodontitis receiving RSV showed lowered ILâ6/ILâ1ÎČ and improved local clinical inflammatory indices.
- Resveratrol Attenuates CSF Markers of Neurodegeneration and Neuroinflammation in Individuals with Alzheimer's Disease
PubMed ID: 40507855
Year-long AD biomarker trial showed reductions in neuroinflammatory markers (MMPâ9, TREM2) indicating meaningful anti-inflammatory CNS effects.
- Effects of resveratrol supplementation on inflammatory markers, fatigue scale, fasting blood sugar and lipid profile in relapsing-remitting multiple sclerosis patients: a double-blind, randomized placebo-controlled trial
PubMed ID: 39565038
MS RCT showed clear TNFâα reduction and anti-inflammatory effectsârobust evidence for inflammation modulation.
- Resveratrol decreases local inflammatory markers and systemic endotoxin in patients with aggressive periodontitis
PubMed ID: 35758374
Dose-dependent reductions in periodontal inflammatory indices and systemic endotoxin in a large RCT demonstrate significant anti-inflammatory effects.
- Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial
PubMed ID: 35240291
24âweek T2DM RCT reduced hsâCRP, TNFâα, ILâ6 and other inflammatory markers.
- Correlation between serum pro inflammatory cytokines and clinical scores of knee osteoarthritic patients using resveratrol as a supplementary therapy with meloxicam
PubMed ID: 34414904
Knee OA trial lowered TNFâα/ILâ1ÎČ/ILâ6 along with clinical pain/function improvements.
- The effects of resveratrol supplementation on PPARα, p16, p53, p21 gene expressions, and sCD163/sTWEAK ratio in patients with type 2 diabetes mellitus: A double-blind controlled randomized trial
PubMed ID: 33580595
Lowered sCD163/sTWEAK ratio in T2D points to favorable shifts in inflammatory balance.
- A randomized exploratory trial to assess the effects of resveratrol on VEGF and TNF-α 2 expression in endometriosis women
PubMed ID: 33387724
Endometrial reductions in VEGF and TNFâα indicate local antiâinflammatory/angiogenic effects.
- Resveratrol treatment in patients with polycystic ovary syndrome decreased pro-inflammatory and endoplasmic reticulum stress markers
PubMed ID: 31483910
Multiple decreased proâinflammatory cytokines (ILâ6, ILâ1ÎČ, TNFâα, CRP) in PCOS trial.
- The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial
PubMed ID: 30777471
Endometrial MMPâ2/9 reductions imply lowered tissue inflammatory/remodelling activity.
- Impact of resveratrol supplementation on inflammatory, antioxidant, and periodontal markers in type 2 diabetic patients with chronic periodontitis
PubMed ID: 31405706
ILâ6 decreased in diabetics with periodontitis though other markers unchanged between groups.
- Preliminary Clinical Effect Evaluation of Resveratrol in Adults with Allergic Rhinitis
PubMed ID: 29539616
Intranasal resveratrol reduced Th2 cytokines, IgE and eosinophils in allergic rhinitisâclear anti-inflammatory effect locally/systemically.
- The Impact of Resveratrol Supplementation on Blood Glucose, Insulin, Insulin Resistance, Triglyceride, and Periodontal Markers in Type 2 Diabetic Patients with Chronic Periodontitis
PubMed ID: 27807887
Periodontitis trial showed reduced pocket depth and improved inflammatory/metabolic indices after 4 weeksâsupportive of local/systemic antiâinflammatory action.
- Resveratrol improves treatment outcome and laboratory parameters in patients with Takayasu arteritis: A randomized double-blind and placebo-controlled trial
PubMed ID: 27771172
250 mg/day for 3 months in Takayasu arteritis significantly reduced BVAS and inflammatory labs (ESR, CRP, TNFâα)âvery strong inflammationâmodulating effect in this vasculitis.
- Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study
PubMed ID: 26002728
6âweek RCT in UC reduced TNFâα, hsâCRP and NFâÎșB activity with clinical improvementâstrong antiâinflammatory evidence in disease.
- Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease
PubMed ID: 23224687
1âyear resveratrolâenriched extract increased adiponectin and suppressed proâinflammatory gene networks in PBMCs.
- Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trial
PubMed ID: 23298135
500 mg/day for 30 days in smokers reduced CRP ~53% â robust antiâinflammatory signal.
- Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium
PubMed ID: 23098852
30âday supplement decreased IFNâÎł and endothelial activation markers (VCAM/ICAM/ILâ8 mRNA) â antiâinflammatory endothelial effects.
- One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease
PubMed ID: 22520621
Oneâyear randomized trial showed marked reductions in hsâCRP, TNFâα and PAIâ1 in highârisk patients.
- Resveratrol Supplementation and Oxidative/Anti-Oxidative Status in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study
PubMed ID: 27664491
Resveratrol RCT in UC decreased MDA and improved disease activityâstrong antiâinflammatory/oxidative modulation in an inflammatory disease.
- Comparative Evaluation of Clinical Efficacy and Safety of Collagen Laminin-Based Dermal Matrix Combined With Resveratrol Microparticles (Dermalix) and Standard Wound Care for Diabetic Foot Ulcers
PubMed ID: 32131656
Topical resveratrol decreased TNF and improved GSH/GSSG in wounds (local antiâinflammatory and oxidative balance).
- Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study
PubMed ID: 29611086
RA RCT showed significant decreases in CRP/ESR, TNFâα, ILâ6 and disease activity with resveratrol (strong antiâinflammatory clinical evidence).
- Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD
PubMed ID: 20119859
Bilberry polyphenol trial lowered several NFâÎșBâregulated inflammatory markers and in vitro resveratrol inhibited NFâÎșB (mechanistic and clinical marker support).
- Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: effects on lipid profiles, inflammation markers, and quality of life
PubMed ID: 23153742
Angina trial reported large CRP and NTâproBNP reductions in resveratrol arms (meaningful antiâinflammatory/cardiac biomarker effects).
- Effects of Nasal Solution Incorporating Resveratrol and Carboxymethyl-Î-Glucan in Preschool Non-Atopic Children with Wheezing
PubMed ID: 39064639
Intermittent nasal resveratrol greatly reduced wheezing and steroid/hospitalization days (strong inflammatory/severity reduction in pediatric viral wheeze).
- Resveratrol plus carboxymethyl-ÎČ-glucan in children with recurrent respiratory infections: a preliminary and real-life experience
PubMed ID: 25416925
Open pediatric nasal therapy decreased symptom days and medication useâevidence of reduced mucosal inflammation (realâworld effect).
Blood circulation (21)
- Effects of resveratrol on vascular tone and endothelial function of human saphenous vein and internal mammary artery
PubMed ID: 16243115
Ex vivo human bypass graft vessels displayed strong NO-mediated vasodilation with resveratrol (large percent relaxation at tested concentrations).
- Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability
PubMed ID: 20093623
Red-wine intervention increased NO availability, reduced ADMA and improved flow-mediated dilationâsupports vascular/blood flow benefits (wine matrix confounds).
- The effect of resveratrol supplementation on serum levels of asymmetric de-methyl-arginine and paraoxonase 1 activity in patients with type 2 diabetes: A randomized, double-blind controlled trial
PubMed ID: 32144833
Resveratrol in T2D lowered ADMA (endogenous NOS inhibitor) and increased PON1, supporting improved endothelial function and blood flow potential.
- Effects of resveratrol supplementation on cardiac remodeling in hypertensive patients: a randomized controlled clinical trial
PubMed ID: 36854725
Hypertensive RCT improved diastolic function (E/e'), LA size and decreased fibrosis markersâbenefits consistent with improved myocardial filling and perfusion.
- Resveratrol improves lipid profile and recovers heart function in postoperative CABG patients
PubMed ID: 40676400
PostâCABG randomized trial: resveratrol lowered systolic BP and improved EF (implying better hemodynamics and blood flow).
- Aterofisiol(Âź) in carotid plaque evolution
PubMed ID: 26229448
Reduced plaque lipid content in carotid plaques and fewer perioperative neurological events imply vascular benefits (resveratrol part of mixture).
- Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus
PubMed ID: 27105868
Acute randomized crossover: single doses of transâresveratrol increased cerebrovascular vasodilator responsiveness by ~9â14% vs placebo in older adults with T2DM.
- Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease
PubMed ID: 16319551
Acute single dose of redâgrape polyphenols markedly improved brachial FMD in coronary heart disease patients.
- Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment
PubMed ID: 22118755
Modified resveratrol supplement improved endothelial function in metabolicâsyndrome patients (multiâcomponent product).
- Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease
PubMed ID: 22240353
10 mg/day improved flowâmediated dilatation and diastolic function in postâMI patients.
- Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium
PubMed ID: 23098852
30âday supplement made plasma less activating to endothelial inflammation and reduced endothelial activation markers â supports improved endothelial milieu.
- The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans
PubMed ID: 26344014
28âday study reported acute cerebral bloodâflow modulation and reduced fatigueâsupports cerebrovascular/flow effects in healthy adults.
- Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus
PubMed ID: 27420093
Duplicate entry to emphasize the strong acute cerebrovascular findings in T2DM (same PMID reinforcing high relevance).
- Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial
PubMed ID: 28054939
Improved cerebrovascular responsiveness in postmenopausal women is direct evidence of improved cerebral perfusion.
- Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults
PubMed ID: 28329397
Improved reactive hyperemia index and increased mitochondrial markers indicate clear vascular perfusion benefits.
- Resveratrol Ameliorates Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Patients With Type 2 Diabetes Mellitus
PubMed ID: 28701674
Reduced arterial stiffness (CAVI) and lowered oxidative stress in T2DM support improved vascular function.
- Resveratrol has a positive effect on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease
PubMed ID: 29059644
In CHD patients, resveratrol reduced ischemic episodes and improved LV functionâconsistent with improved myocardial perfusion/flow.
- Angiographic and Clinical Outcomes After Treatment of Femoro-Popliteal Lesions with a Novel Paclitaxel-Matrix-Coated Balloon Catheter
PubMed ID: 28660441
Device trial (paclitaxelâresveratrol matrix) produced superior angiographic results and improved walking distance in PAD (local blood flow).
- Two-Year Clinical Outcomes of the CONSEQUENT Trial: Can Femoropopliteal Lesions be Treated with Sustainable Clinical Results that are Economically Sound?
PubMed ID: 29589098
Resveratrolâcoated DCB improved vessel patency and walking distance in femoropopliteal disease.
- Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study
PubMed ID: 32900519
Long-term trial improved cerebral blood flow velocity and resting CBFVâstrong evidence for cerebrovascular support.
- Hemorheological Alterations in Patients with Heart Failure with Reduced Ejection Fraction Treated by Resveratrol
PubMed ID: 32695229
Reduced RBC aggregation in HFrEF patients may improve microvascular flow; 6MWT increased.
Heart health (20)
- The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease
PubMed ID: 31486447
T2DM+CHD patients had improved glycaemia and HDL â relevant to cardiac risk.
- Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study
PubMed ID: 32900519
Long-term improvements in cerebrovascular flow and insulin sensitivity that may support cardiovascular health.
- Hemorheological Alterations in Patients with Heart Failure with Reduced Ejection Fraction Treated by Resveratrol
PubMed ID: 32695229
HFrEF patients had reduced RBC aggregation and modest 6MWT gain with 100 mg/day.
- Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial
PubMed ID: 35240291
Improved glycaemia, inflammation and oxidative stress over 24 weeks â cardioprotective markers.
- Effects of resveratrol on vascular tone and endothelial function of human saphenous vein and internal mammary artery
PubMed ID: 16243115
(duplicate entry to reflect strong blood-flow/NO effect relevant to heart support via improved vascular relaxation).
- Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability
PubMed ID: 20093623
Daily moderate red-wine (polyphenol-rich) increased EPCs and NO availability and improved flow-mediated dilationâmechanistically favorable for heart/vascular health (wine matrix confounds attribution).
- Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial
PubMed ID: 30278430
100 mg/day for 2 months modestly lowered total cholesterol and triglycerides in dyslipidemic adults, beneficial for heart risk profile.
- The effect of resveratrol supplementation on serum levels of asymmetric de-methyl-arginine and paraoxonase 1 activity in patients with type 2 diabetes: A randomized, double-blind controlled trial
PubMed ID: 32144833
1000 mg/day resveratrol in T2D lowered ADMA and raised PON1 (vascular/antiâatherosclerotic biomarkers relevant to cardiac health).
- Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: effects on lipid profiles, inflammation markers, and quality of life
PubMed ID: 23153742
Short angina trial: resveratrol arms showed marked decreases in CRP and NTâproBNP (cardiac biomarker improvements).
- Effects of resveratrol supplementation on cardiac remodeling in hypertensive patients: a randomized controlled clinical trial
PubMed ID: 36854725
Sixâmonth RCT in hypertensives: improved diastolic/LA measures and lower fibrosis biomarkers (clinically meaningful cardiac remodeling benefit).
- Resveratrol improves lipid profile and recovers heart function in postoperative CABG patients
PubMed ID: 40676400
PostâCABG randomized trial: 60 days resveratrol improved lipids, lowered systolic BP and improved ejection fraction (strong clinical cardiac outcome evidence).
- Aterofisiol(Âź) in carotid plaque evolution
PubMed ID: 26229448
Multiâingredient trial in carotid endarterectomy patients reduced plaque lipid/cholesterol and perioperative neurological eventsâcardiovascular benefit (resveratrol part of mixture).
- Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease
PubMed ID: 16319551
Single dose of redâgrape polyphenols acutely improved FMD in coronary heart disease patients â vascular/heart benefit.
- Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment
PubMed ID: 22118755
Modified resveratrol product improved endothelial function in metabolicâsyndrome patients (multiâcomponent formulation).
- Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial
PubMed ID: 22648627
6âmonth grape extract with lowâdose resveratrol lowered oxidized LDL and ApoB and modestly reduced LDLc in statinâtreated patients.
- One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease
PubMed ID: 22520621
Oneâyear resveratrolârich supplement lowered inflammatory/fibrinolytic markers in high cardiovascular risk patients â cardioprotective signal.
- Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease
PubMed ID: 22240353
10 mg/day for 3 months postâMI improved endothelial and diastolic function and lowered LDL vs placebo.
- Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease
PubMed ID: 23224687
1âyear resveratrolâenriched extract increased adiponectin, lowered PAIâ1 and suppressed PBMC inflammatory genes in CAD patients.
- Resveratrol Ameliorates Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Patients With Type 2 Diabetes Mellitus
PubMed ID: 28701674
T2DM trial reduced arterial stiffness (CAVI), oxidative stress and modestly lowered systolic BP â vascular/cardiac support.
- Resveratrol has a positive effect on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease
PubMed ID: 29059644
In stable coronary heart disease, 100 mg/day resveratrol improved LV systolic/diastolic function and reduced ischemic episodes and arrhythmias.
Cell health (21)
- Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation
PubMed ID: 29330620
Highâdose resveratrol increased SIRT1 in some T2DM patients with linked increases in antioxidant activity and histone changes â cellular protection signal.
- Beneficial Role of Resveratrol on Oxidative Stress in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial
PubMed ID: 40877487
800 mg/day in PCOS improved follicular fluid antioxidant markers (TAC, TOS, OSI, thiols) â direct cellular antioxidant protection.
- Resveratrol Attenuates CSF Markers of Neurodegeneration and Neuroinflammation in Individuals with Alzheimer's Disease
PubMed ID: 40507855
1âyear AD trial reduced CSF neuronal damage markers (NSE, MMPâ9, TREM2), indicating protection at neuronal/cellular level.
- The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women-A Pilot Randomized Clinical Trial
PubMed ID: 39519608
Postmenopausal trial (RSV±vit C) reduced oxidative-damage markers and raised TACâsupports cellular antioxidant protection.
- Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer
PubMed ID: 22332908
Doseâdependent circulating resveratrol associated with decreased RASSFâ1α methylation â epigenetic tumorâsuppressor effect.
- Biological and clinical effects of a resveratrol-based multivitamin supplement on intracytoplasmic sperm injection cycles: a single-center, randomized controlled trial
PubMed ID: 34338114
Improved oocyte/embryo quality endpoints with a resveratrolâcontaining supplement suggest cellular protection of gametes (multinutrient intervention).
- The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 29357033
RCT in T2D increased TAC, upregulated Nrf2/SOD and reduced protein oxidationâstrong cellular antioxidant/protective signal.
- Resveratrol Supplementation and Oxidative/Anti-Oxidative Status in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study
PubMed ID: 27664491
Resveratrol RCT in ulcerative colitis raised SOD/TAC and lowered MDA, indicating cellular oxidative protection.
- Comparative Evaluation of Clinical Efficacy and Safety of Collagen Laminin-Based Dermal Matrix Combined With Resveratrol Microparticles (Dermalix) and Standard Wound Care for Diabetic Foot Ulcers
PubMed ID: 32131656
Topical resveratrol device doubled wound closure and reduced oxidative/inflammatory markers (cellular protection at wound site).
- Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes
PubMed ID: 37108584
Highâdose RSV in older T2D increased SIRT1 and TAC and reduced oxidative damage markersâstrong cellular-protective biomarker changes.
- Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial
PubMed ID: 35240291
Reduced oxidativeâstress markers (MDA) and inflammatory markers over 24 weeks.
- The effects of resveratrol supplementation on PPARα, p16, p53, p21 gene expressions, and sCD163/sTWEAK ratio in patients with type 2 diabetes mellitus: A double-blind controlled randomized trial
PubMed ID: 33580595
Raised p53/p21 expression and reduced inflammatory ratio in T2D, suggesting effects on cell stress and protective signaling.
- Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial
PubMed ID: 33068691
Exercise trial showed increased citrate synthase (mitochondrial marker) with 1000 mg.
- CSF from amyotrophic lateral sclerosis patients produces glutamate independent death of rat motor brain cortical neurons: protection by resveratrol but not riluzole
PubMed ID: 21983205
In vitro resveratrol prevented human ALS CSFâinduced neuronal death (mechanistic neuroâcellular protection).
- Resveratrol ameliorates mitochondrial biogenesis and reproductive outcomes in women with polycystic ovary syndrome undergoing assisted reproduction: a randomized, triple-blind, placebo-controlled clinical trial
PubMed ID: 38987824
800 mg/day resveratrol in PCOS improved follicular antioxidant status, mitochondrial biogenesis and ATP â strong cellular/mitochondrial protection evidence.
- Effects of 6Â months of resveratrol versus placebo on pentraxin 3 in patients with type 2 diabetes mellitus: a double-blind randomized controlled trial
PubMed ID: 28238190
Dose-dependent increase in total antioxidant status (TAS) in T2DM suggests improved cellular antioxidant defenses.
- Antioxidant Activity with Increased Endogenous Levels of Vitamin C, E and A Following Dietary Supplementation with a Combination of Glutathione and Resveratrol Precursors
PubMed ID: 33105552
Polydatin + glutathione precursors robustly increased erythrocyte GSH and antioxidant vitamins, indicating cellular antioxidant protection.
- Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after Caloric Restriction and Resveratrol Administration
PubMed ID: 30037068
Increased Sirt1 gene expression in peripheral bloodâbiomarker consistent with cellular-protection pathways.
- Resveratrol treatment in patients with polycystic ovary syndrome decreased pro-inflammatory and endoplasmic reticulum stress markers
PubMed ID: 31483910
Decreased ERâstress genes (CHOP/GRP78/XBP1) and inflammatory cytokines in PCOS cells.
- Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults
PubMed ID: 28329397
Increased skeletal muscle mitochondrial number and mitochondrial gene signatures in glucose-intolerant older adults.
- Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial
PubMed ID: 28029409
30âday 500 mg/day increased circulating Sirt1 proteinâbiomarker linked to cellular stress resistance and mitochondrial regulation.
Immune support (15)
- Resveratrol plus carboxymethyl-ÎČ-glucan reduces nasal symptoms in children with pollen-induced allergic rhinitis
PubMed ID: 24983742
Intranasal resveratrol+ÎČâglucan RCT in allergic children reduced nasal symptoms and antihistamine use (direct clinical immune/antiâallergic effect).
- Resveratrol plus carboxymethyl-ÎČ-glucan in children with recurrent respiratory infections: a preliminary and real-life experience
PubMed ID: 25416925
Open randomized pediatric study with resveratrol+ÎČâglucan nasal therapy reduced symptom days and medication use (supports mucosal immune benefit).
- Effects of Nasal Solution Incorporating Resveratrol and Carboxymethyl-Î-Glucan in Preschool Non-Atopic Children with Wheezing
PubMed ID: 39064639
Pediatric randomized trial: intermittent nasal resveratrol+ÎČâglucan markedly reduced wheeze and steroid/hospitalization days (strong clinical immune/antiâinflammatory effect).
- Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study
PubMed ID: 29611086
RA RCT: oral resveratrol reduced disease activity and inflammatory cytokines, implying immuneâmodulating effects.
- Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium
PubMed ID: 23098852
Reduced plasma IFN-Îł and endothelial inflammatory signaling after 30 days â supports immune/inflammatory modulation.
- Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study
PubMed ID: 26002728
RCT in ulcerative colitis showed reduced TNF-α, hsâCRP and NFâÎșB activityâclear immunoâmodulatory effect in an inflammatory condition.
- Resveratrol improves treatment outcome and laboratory parameters in patients with Takayasu arteritis: A randomized double-blind and placebo-controlled trial
PubMed ID: 27771172
Randomized trial in Takayasu arteritis produced declines in inflammatory markers (TNFâα, CRP, ESR) and disease activityâstrong immune/inflammation modulation.
- The Impact of Resveratrol Supplementation on Blood Glucose, Insulin, Insulin Resistance, Triglyceride, and Periodontal Markers in Type 2 Diabetic Patients with Chronic Periodontitis
PubMed ID: 27807887
Diabetics with periodontitis had reduced pocket depth and improved insulin indices after resveratrolâlocal immune/inflammatory improvement.
- Resveratrol improves efficacy of oral amoxicillin against childhood fast breathing pneumonia in a randomized placebo-controlled double blind clinical trial
PubMed ID: 29198820
Large RCT in pediatric pneumonia showed adjunctive resveratrol reduced early treatment failure, consistent with enhanced anti-infective/immune effect.
- Preliminary Clinical Effect Evaluation of Resveratrol in Adults with Allergic Rhinitis
PubMed ID: 29539616
Intranasal resveratrol reduced IgE, Th2 cytokines and eosinophils and improved symptoms in allergic rhinitis.
- Resveratrol treatment in patients with polycystic ovary syndrome decreased pro-inflammatory and endoplasmic reticulum stress markers
PubMed ID: 31483910
Reduced multiple proâinflammatory cytokines in PCOS, implying immune modulation.
- Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial
PubMed ID: 35240291
24âweek T2DM trial reduced hsâCRP, TNFâα, ILâ6 (systemic inflammatory/immune markers).
- Effects of resveratrol supplementation on inflammatory markers, fatigue scale, fasting blood sugar and lipid profile in relapsing-remitting multiple sclerosis patients: a double-blind, randomized placebo-controlled trial
PubMed ID: 39565038
8âweek RCT in MS lowered TNF-α and moderated metabolic changes, consistent with immunomodulation in an immune-mediated disease.
- Effects of resveratrol on inflammatory cytokines in COVID-19 patients: a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 40301181
10âday COVID RCT produced significant reductions in CRP/ILâ1ÎČ/TNFâα and improved blood countsârobust anti-inflammatory/immune signals.
- Efficacy of a Mouthwash Containing Resveratrol in Reducing Halitosis-related P. gingivalis: A Randomized Triple-blind Trial
PubMed ID: 41328922
Resveratrol mouthwash drastically lowered P. gingivalis and halitosis, demonstrating direct antibacterial/mucosal immune benefit.
Metabolism (18)
- The effects of resveratrol supplementation on cardiovascular risk factors in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study
PubMed ID: 26234526
12 weeks 500 mg/day lowered ALT and hepatic steatosis though effects on lipids/BP/insulin were absent.
- A randomized controlled trial comparing the efficacy of resveratrol combined with metformin versus resveratrol monotherapy in the management of polycystic ovary syndrome
PubMed ID: 40888876
6âmonth PCOS RCT (RSV ± metformin) improved BMI and fasting glucose (stronger with combo)âconsistent metabolic/reproductive metabolic benefits.
- Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial
PubMed ID: 35240291
24âweek trial improved fasting glucose, HOMAâIR and multiple metabolic/inflammatory markers.
- Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions
PubMed ID: 32152335
Melinjo extract (resveratrol derivatives) increased HMW/total adiponectin ratio implicating metabolic signalling.
- Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study
PubMed ID: 32900519
Long-term trial in postmenopausal women improved insulin sensitivity alongside cognitive and cerebrovascular benefits.
- The Effect of Resveratrol Supplementation on Cardio-Metabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, Double-Blind Controlled Trial
PubMed ID: 31475415
1000 mg/day in overweight T2DM lowered fasting glucose and insulin, raised HDL.
- The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease
PubMed ID: 31486447
500 mg/day for 4 weeks improved fasting glucose, HOMA and HDL in T2DM+CHD.
- Resveratrol supplementation decreases blood glucose without changing the circulating CD14(+)CD16(+) monocytes and inflammatory cytokines in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study
PubMed ID: 29914666
Small T2D RCT reported reductions in fasting glucose and blood pressure after 8 weeks.
- The Impact of Resveratrol Supplementation on Blood Glucose, Insulin, Insulin Resistance, Triglyceride, and Periodontal Markers in Type 2 Diabetic Patients with Chronic Periodontitis
PubMed ID: 27807887
Diabetics had improved fasting insulin and HOMAâIR after 4 weeksâsupportive of insulinâsensitivity/metabolic effects.
- Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease
PubMed ID: 23224687
1âyear resveratrolâenriched extract increased adiponectin and modulated metabolic/inflammatory gene networks in CAD patients.
- Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity
PubMed ID: 39182247
EGCG+resveratrol preserved fat oxidation and muscle oxidative capacityâmetabolic substrate utilization benefit.
- Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial
PubMed ID: 27194304
EGCG+resveratrol increased skeletal muscle mitochondrial capacity and favored fat oxidationâclear metabolic effects (combined supplement).
- The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 29357033
In T2D improved antioxidant defenses which often accompany metabolic benefits; study population metabolic disease adds relevance.
- Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial
PubMed ID: 27754722
PCOS trial: resveratrol lowered androgens and substantially improved insulin sensitivityâdirect metabolic benefit.
- Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span
PubMed ID: 32758058
Prediabetic trial: lowâdose resveratrol+leucine markedly improved HOMAâIR and OGTT responses (strong metabolic/insulinâsensitivity signal for the combo).
- Treatment with combined resveratrol and myoinositol ameliorates endocrine, metabolic alterations and perceived stress response in women with PCOS: a double-blind randomized clinical trial
PubMed ID: 36169918
Combined resveratrol+myoâinositol in PCOS improved metabolic measures, adiponectin and weight (combination limits attribution but supports metabolic benefit).
- Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease
PubMed ID: 25311610
500 mg/day plus lifestyle for 12 weeks improved liver enzymes, inflammation and steatosisâmetabolic benefits in NAFLD patients.
- Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial
PubMed ID: 25577300
300 mg/day for 3 months in NAFLD improved glycemia and insulin-resistance markers versus placebo.
Antioxidant (17)
- Resveratrol treatment in patients with polycystic ovary syndrome decreased pro-inflammatory and endoplasmic reticulum stress markers
PubMed ID: 31483910
Lowered inflammatory cytokines and ERâstress genes suggesting reduced oxidative/ER stress.
- Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial
PubMed ID: 35240291
24âweek trial reduced MDA and other oxidativeâstress markers in T2DM.
- Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes
PubMed ID: 37108584
Dose-dependent increases in TAC and reduced lipoperoxides in older T2Dâstrong systemic antioxidant biomarker evidence.
- The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women-A Pilot Randomized Clinical Trial
PubMed ID: 39519608
RSV±vitamin C reduced LPH/MDA and raised TAC in postmenopausal womenâconsistent antioxidant protection.
- Antioxidant Activity with Increased Endogenous Levels of Vitamin C, E and A Following Dietary Supplementation with a Combination of Glutathione and Resveratrol Precursors
PubMed ID: 33105552
Polydatin + glutathione precursors increased GSH by ~40% and raised endogenous antioxidant vitamins, indicating strong antioxidant effects.
- Effects of 6Â months of resveratrol versus placebo on pentraxin 3 in patients with type 2 diabetes mellitus: a double-blind randomized controlled trial
PubMed ID: 28238190
Dose-dependent increases in total antioxidant status (TAS) in T2DM subjects.
- Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress
PubMed ID: 16046716
Grape powder polyphenols reduced urinary F2âisoprostanes (wholeâbody oxidative stress marker) â supports antioxidant action of polyphenols including resveratrol.
- The effect of resveratrol supplementation on serum levels of asymmetric de-methyl-arginine and paraoxonase 1 activity in patients with type 2 diabetes: A randomized, double-blind controlled trial
PubMed ID: 32144833
PON1 activity increased in T2D trial (antioxidant/antiâlipoperoxidation enzyme), supporting antioxidant-related vascular protection.
- Resveratrol ameliorates mitochondrial biogenesis and reproductive outcomes in women with polycystic ovary syndrome undergoing assisted reproduction: a randomized, triple-blind, placebo-controlled clinical trial
PubMed ID: 38987824
Follicular fluid TAC increased and TOS/OSI decreased with resveratrol in IVF patients (direct antioxidant improvements in target tissue).
- Resveratrol Supplementation and Oxidative/Anti-Oxidative Status in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study
PubMed ID: 27664491
Resveratrol RCT in ulcerative colitis increased SOD/TAC and reduced MDA with symptomatic improvementâclear antioxidant protection.
- The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 29357033
Robust RCT in T2D showing increased TAC, total thiols, lowered protein carbonyls and upregulation of Nrf2/SODâstrong antioxidant evidence.
- Beneficial Role of Resveratrol on Oxidative Stress in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial
PubMed ID: 40877487
800 mg/day resveratrol improved multiple antioxidant measures (TAC, TOS, OSI, thiols) in follicular fluid of women with PCOS.
- Circadian Modulation of the Antioxidant Effect of Grape Consumption: A Randomized Controlled Trial
PubMed ID: 37569042
Timed grape intake blunted mealâinduced oxidative stress (urine F2âisoprostanes) â antioxidant effect from grape polyphenols containing resveratrol.
- Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trial
PubMed ID: 23298135
500 mg/day for 30 days in smokers markedly increased total antioxidant status and reduced CRP/triglycerides.
- Alterations of antioxidant status in asymptomatic hypercholesterolemic individuals after resveratrol intake
PubMed ID: 27108746
4âweek crossover increased total antioxidant capacity and raised vitamin E in hypercholesterolemic subjectsâsupportive though modest and subgroupâspecific.
- Resveratrol Ameliorates Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Patients With Type 2 Diabetes Mellitus
PubMed ID: 28701674
T2DM trial reduced oxidative stress markers (d-ROMs) alongside decreased arterial stiffness.
- Resveratrol reduces albuminuria in diabetic nephropathy: A randomized double-blind placebo-controlled clinical trial
PubMed ID: 29983230
In T2D with albuminuria, resveratrol raised antioxidant enzyme levels and reduced albuminuria (clinical correlate).
Wellbeing (13)
- Resveratrol Supplementation and Oxidative/Anti-Oxidative Status in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study
PubMed ID: 27664491
Clinical UC RCT showed disease activity reduction and QoL improvement with resveratrol (meaningful overall wellbeing effect).
- Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study
PubMed ID: 26002728
UC patients had reduced inflammatory biomarkers and improved disease activity/qualityâofâlife scoresâdirect impact on wellbeing in this population.
- [Preliminary data on the effectiveness of resveratrol in a new formulation in treatment of hot flushes]
PubMed ID: 26491826
Large differences in responder rates for hot flush frequency/intensity and QoL indicate notable improvements in menopausal wellbeing.
- Resveratrol improves treatment outcome and laboratory parameters in patients with Takayasu arteritis: A randomized double-blind and placebo-controlled trial
PubMed ID: 27771172
Takayasu arteritis patients experienced reduced disease activity and inflammatory markersâmeaningful improvement in clinical wellbeing.
- Resveratrol supplementation reduces pain experience by postmenopausal women
PubMed ID: 28350759
14-week trial in postmenopausal women reduced pain and improved reported wellbeing (clinical outcome).
- Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial
PubMed ID: 28054939
Improvements in cognition, cerebrovascular responsiveness and reduced anxiety indicate better wellbeing.
- Resveratrol improves efficacy of oral amoxicillin against childhood fast breathing pneumonia in a randomized placebo-controlled double blind clinical trial
PubMed ID: 29198820
Reduced early treatment failure in pediatric pneumonia implies improved clinical outcomes/wellbeing.
- Resveratrol in Patients with Minimal Hepatic Encephalopathy
PubMed ID: 29522439
Combined-supplement study in cirrhosis reported improved QoL and mood alongside biochemical changes.
- Efficacy and safety of co-administration of resveratrol with meloxicam in patients with knee osteoarthritis: a pilot interventional study
PubMed ID: 30233159
OA patients reported improved function and symptoms, consistent with enhanced quality of life.
- Preliminary Clinical Effect Evaluation of Resveratrol in Adults with Allergic Rhinitis
PubMed ID: 29539616
Intranasal resveratrol improved nasal symptoms and quality-of-life metrics in allergic rhinitis.
- Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study
PubMed ID: 32900519
Long-term trial showed improvements across cognition, cerebral blood flow and metabolic markers supportive of wellbeing.
- Resveratrol Adjunct Therapy for Negative Symptoms in Patients With Stable Schizophrenia: A Double-Blind, Randomized Placebo-Controlled Trial
PubMed ID: 33372679
Schizophrenia addâon improved overall PANSS total and general psychopathology.
- Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial
PubMed ID: 32881835
24âmonth RCT showed improved general wellâbeing and menopauseârelated symptoms.
Blood sugar (14)
- Can trans resveratrol plus d-chiro-inositol and myo-inositol improve maternal metabolic profile in overweight pregnant patients?
PubMed ID: 28703838
Trans-resveratrol + myo/DCI improved glucose in overweight pregnant women vs controls (combination product confounds).
- Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial
PubMed ID: 35240291
Robust 24âweek improvement in fasting glucose and HOMAâIR in T2DM trial.
- Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study
PubMed ID: 32900519
24-month study in postmenopausal women improved fasting insulin and insulin resistance measures.
- The Effect of Resveratrol Supplementation on Cardio-Metabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, Double-Blind Controlled Trial
PubMed ID: 31475415
1000 mg/day for 8 weeks lowered fasting glucose and insulin in overweight T2DM.
- The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease
PubMed ID: 31486447
500 mg/day for 4 weeks improved fasting glucose and HOMA indices in T2DM+CHD.
- Resveratrol supplementation decreases blood glucose without changing the circulating CD14(+)CD16(+) monocytes and inflammatory cytokines in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study
PubMed ID: 29914666
8-week RCT in T2D reported significant reduction in fasting glucose.
- The Impact of Resveratrol Supplementation on Blood Glucose, Insulin, Insulin Resistance, Triglyceride, and Periodontal Markers in Type 2 Diabetic Patients with Chronic Periodontitis
PubMed ID: 27807887
Diabetic patients showed improved fasting insulin and HOMAâIR after 4 weeksâsupportive for glycemic control.
- Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study
PubMed ID: 24866496
12 weeks of 300â1000 mg/day resveratrol stabilized glucose relative to placebo in overweight older adults.
- Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus
PubMed ID: 22901562
250 mg/day for 3 months in T2DM modestly improved HbA1c â clinical glycemic benefit (openâlabel).
- Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults
PubMed ID: 24899709
200 mg/day for 26 weeks lowered HbA1c in overweight older adults â improved glycemic marker.
- Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial
PubMed ID: 27754722
PCOS study: resveratrol significantly reduced fasting insulin and increased insulin sensitivity (Matsuda index) â strong glycemic benefit.
- Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span
PubMed ID: 32758058
Prediabetic 4âweek resveratrol+leucine trial produced ~33% HOMAâIR reduction and improved OGTT responses (strong glycemic improvement for the combo).
- A randomized controlled trial comparing the efficacy of resveratrol combined with metformin versus resveratrol monotherapy in the management of polycystic ovary syndrome
PubMed ID: 40888876
PCOS 6âmonth RCT showed improved fasting glucose (especially with RSV+metformin)âmeaningful glycemic benefit in that population.
- Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial
PubMed ID: 25577300
300 mg/day for 3 months in NAFLD improved glycemia and insulin-resistance markers compared with placebo.
Cholesterol (13)
- Aterofisiol(Âź) in carotid plaque evolution
PubMed ID: 26229448
Supplement (including resveratrol) reduced plaque lipid and plaque cholesterol in carotid endarterectomy patientsâlipid benefits in vascular tissue.
- Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial
PubMed ID: 22648627
6âmonth trial in statinâtreated patients: modest LDLc decrease and marked reductions in oxidized LDL and ApoB.
- Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus
PubMed ID: 22901562
Total cholesterol modestly decreased in T2DM trial (openâlabel).
- Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease
PubMed ID: 22240353
10 mg/day for 3 months postâMI lowered LDL in a small RCT.
- Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trial
PubMed ID: 23298135
Triglycerides decreased in smokers after 30 days of 500 mg/day resveratrol.
- The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease
PubMed ID: 31486447
Raised HDL in T2DM+CHD after 4 weeks.
- The Effect of Resveratrol Supplementation on Cardio-Metabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, Double-Blind Controlled Trial
PubMed ID: 31475415
1000 mg/day increased HDL and modestly affected lipids in overweight T2DM.
- The short-term supplementation of monacolin K improves the lipid and metabolic patterns of hypertensive and hypercholesterolemic subjects at low cardiovascular risk
PubMed ID: 29951651
Oneâmonth multiâingredient nutraceutical including resveratrol produced large TC and LDL reductions (strong lipid changes, but multiâingredient).
- Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress
PubMed ID: 16046716
Grape powder lowered triglycerides and LDLârelated measures (polyphenol mix including resveratrol; supports lipid improvements).
- Effectiveness and Safety of Novel Nutraceutical Formulation Added to Ezetimibe in Statin-Intolerant Hypercholesterolemic Subjects with Moderate-to-High Cardiovascular Risk
PubMed ID: 32456525
Nutraceutical mixture including trans-resveratrol plus ezetimibe produced greater LDL/TC reductions than ezetimibe alone (multi-ingredient confounding).
- Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial
PubMed ID: 30278430
100 mg/day for 2 months lowered total cholesterol and triglycerides significantly in dyslipidemic adults.
- Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial
PubMed ID: 25577300
300 mg/day improved LDL in NAFLD patients over 3 months.
- Resveratrol improves lipid profile and recovers heart function in postoperative CABG patients
PubMed ID: 40676400
PostâCABG randomized trial: resveratrol reduced total and LDL cholesterol (clear clinical lipid improvements in a resveratrol RCT).
Brain health (13)
- Effect of Resveratrol Combined with Donepezil Hydrochloride on Inflammatory Factor Level and Cognitive Function Level of Patients with Alzheimer's Disease
PubMed ID: 35368930
Adjunct RSV+donepezil lowered inflammatory markers and improved MMSE/ADASâcog vs donepezil aloneâsuggests potential cognitive benefit though confounded.
- CSF from amyotrophic lateral sclerosis patients produces glutamate independent death of rat motor brain cortical neurons: protection by resveratrol but not riluzole
PubMed ID: 21983205
In vitro protection of motor neurons against ALS patient CSF toxicity by resveratrol suggests mechanistic neuroprotection potential.
- Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus
PubMed ID: 27105868
Singleâdose transâresveratrol acutely increased cerebral vasodilator responsiveness in older adults with T2DMâdirect brain bloodâflow effect.
- Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults
PubMed ID: 24899709
26âweek trial in older adults showed improved shortâterm memory retention and increased hippocampal functional connectivity.
- The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans
PubMed ID: 26344014
28âday trial found acute CBF changes and reduced fatigue with minimal cognitive improvementâmoderate brain support for perfusion and subjective symptoms.
- Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus
PubMed ID: 27420093
Acute single doses (75 mg) in T2DM adults produced robust increases in taskârelated cerebral blood flow (~35% peak) and improved performance indexâstrong cerebrovascular/cognitive support.
- Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease
PubMed ID: 28086917
Year-long randomized trial in mild-moderate AD showed CSF biomarker stabilization, reduced MMP9 and attenuated functional decline signals.
- Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial
PubMed ID: 28054939
14-week RCT improved overall cognitive performance and cerebrovascular responsiveness in postmenopausal women.
- Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study
PubMed ID: 29583015
Pilot trial in older adults improved psychomotor speed at higher dose, limited broader cognitive effects.
- Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study
PubMed ID: 32900519
24-month RCT in postmenopausal women showed improved cognition and cerebral blood flowâstrong clinical brain support.
- Resveratrol Adjunct Therapy for Negative Symptoms in Patients With Stable Schizophrenia: A Double-Blind, Randomized Placebo-Controlled Trial
PubMed ID: 33372679
Significant improvements in negative and overall symptoms implicate central effects.
- Resveratrol adjunct to methylphenidate improves symptoms of attention-deficit/hyperactivity disorder: a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 32449130
Adjunctive improvements in ADHD parent ratings suggest cognitive/behavioral benefit.
- Resveratrol Attenuates CSF Markers of Neurodegeneration and Neuroinflammation in Individuals with Alzheimer's Disease
PubMed ID: 40507855
Oneâyear AD RCT produced substantial CSF biomarker reductions linked to neuronal damage and neuroinflammationâstrong brain-protective signal.
Healthy aging (12)
- Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial
PubMed ID: 32564438
Twoâyear randomized trial: lowâdose resveratrol produced small but significant increases in spine/hip BMD and reduced bone resorption (clinically relevant aging support).
- The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 29357033
Antioxidant gene upregulation (Nrf2/SOD) and reduced oxidative damage in T2D support cellular aging defenses.
- Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women
PubMed ID: 28505227
Enhanced muscle mass, strength and mitochondrial indices in older adults support functional aspects of healthy aging.
- Resveratrol treatment increases sirtuin 1 levels and alleviates frailty phenotype in knee osteoarthritis patients: a randomised placebo-controlled clinical trial
PubMed ID: 40990472
Resveratrol reduced frailty measures and improved strength in older knee OA patients and increased SIRT1 â relevant to healthy aging.
- Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults
PubMed ID: 24899709
Cognitive retention and hippocampal connectivity improvements in older adults, plus HbA1c reduction â supports healthy brain aging.
- Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial
PubMed ID: 28029409
Increased circulating Sirt1 (biomarker linked to aging pathways) after 30 days suggests a plausible healthyâaging mechanism.
- Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study
PubMed ID: 32900519
Long-term RCT showed cognitive, cerebrovascular and insulin-sensitivity improvements relevant to healthy aging.
- Equol and Resveratrol Improve Bone Turnover Biomarkers in Postmenopausal Women: A Clinical Trial
PubMed ID: 37569440
Equol+RSV reduced bone resorption and increased BMD in postmenopausal womenârelevant to healthy aging skeleton.
- Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes
PubMed ID: 37108584
SIRT1 increase and reduced oxidative markers in older T2D are mechanistically linked to aging pathways.
- Resveratrol Attenuates CSF Markers of Neurodegeneration and Neuroinflammation in Individuals with Alzheimer's Disease
PubMed ID: 40507855
Year-long AD biomarker improvements (reduced neuronal damage/inflammation) suggest potential age-related neuroprotection.
- Effects of resveratrol on bone health in type 2 diabetic patients. A double-blind randomized-controlled trial
PubMed ID: 30237505
500 mg/day for 6 months modestly preserved/increased whole-body BMD/BMC in T2DM, a marker of healthy aging-related bone maintenance.
- Antioxidant Activity with Increased Endogenous Levels of Vitamin C, E and A Following Dietary Supplementation with a Combination of Glutathione and Resveratrol Precursors
PubMed ID: 33105552
Increases in GSH and antioxidant vitamins could support cellular resilience relevant to healthy aging.
Joint comfort (9)
- Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study
PubMed ID: 29611086
Randomized RA trial: 1 g/day resveratrol added to standard care reduced DAS28 and joint counts (clinically meaningful joint symptom improvement).
- Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial
PubMed ID: 38138300
Rehab plus supplements including 50 mg resveratrol reduced pain and disability in discogenic sciatica (confounded by rehab and multiple actives).
- Correlation between serum pro inflammatory cytokines and clinical scores of knee osteoarthritic patients using resveratrol as a supplementary therapy with meloxicam
PubMed ID: 34414904
Large clinical improvement in pain/function (KOOS/WOMAC/VAS) in knee OA when added to meloxicam.
- Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial
PubMed ID: 32881835
Postmenopausal trial reported reduced chronic pain and improved somatic symptoms.
- Efficacy and safety of co-administration of resveratrol with meloxicam in patients with knee osteoarthritis: a pilot interventional study
PubMed ID: 30233159
90-day RCT in knee osteoarthritis showed significant improvements in WOMAC pain and function with add-on resveratrol.
- Resveratrol supplementation reduces pain experience by postmenopausal women
PubMed ID: 28350759
Postmenopausal trial reported reduced chronic pain and improved wellbeing correlated with cerebrovascular responsiveness.
- Resveratrol increases bone mineral density and bone alkaline phosphatase in obese men: a randomized placebo-controlled trial
PubMed ID: 25322274
RCT in obese men with MetS showed increased bone formation marker (BAP) and small lumbar trabecular vBMD gainâsupports bone health which can relate to joint/bone comfort.
- Resveratrol treatment increases sirtuin 1 levels and alleviates frailty phenotype in knee osteoarthritis patients: a randomised placebo-controlled clinical trial
PubMed ID: 40990472
16âweek RCT: 500 mg/day reduced OA symptoms and frailty markers and raised SIRT1 in older knee OA patients.
- Resveratrol supplementation improves functional performance in knee osteoarthritis by upregulating sirtuin 1: a randomized study
PubMed ID: 41037125
12âweek RCT in knee OA: 500 mg/day resveratrol improved pain and multiple functional measures and increased SIRT1.
Mood balance (6)
- Resveratrol Adjunct Therapy for Negative Symptoms in Patients With Stable Schizophrenia: A Double-Blind, Randomized Placebo-Controlled Trial
PubMed ID: 33372679
Addâon resveratrol improved negative and overall PANSS scores in schizophrenia.
- Resveratrol in Patients with Minimal Hepatic Encephalopathy
PubMed ID: 29522439
Cirrhotic-patient trial (combined supplements) improved depression/anxiety scores and quality of life.
- Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial
PubMed ID: 28054939
14-week RCT in postmenopausal women reduced anxiety and improved cognition and cerebrovascular responsiveness.
- Resveratrol supplementation reduces pain experience by postmenopausal women
PubMed ID: 28350759
Postmenopausal trial reported improved overall well-being in parallel with pain reduction and vascular changes.
- [Preliminary data on the effectiveness of resveratrol in a new formulation in treatment of hot flushes]
PubMed ID: 26491826
Pilot trial showed marked reductions in hot flush frequency/intensity and improved QoLâmenopausal symptom relief often accompanies mood benefits.
- Resveratrol in Hepatitis C Patients Treated with Pegylated-Interferon-α-2b and Ribavirin Reduces Sleep Disturbance
PubMed ID: 28820468
Resveratrol added to hepatitis C therapy associated with better mood scores and less sleep disturbance in that trial.
Exercise recovery (5)
- Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial
PubMed ID: 33068691
In older adults, 1000 mg + exercise increased 6âminute walk distance and mitochondrial markers.
- Hemorheological Alterations in Patients with Heart Failure with Reduced Ejection Fraction Treated by Resveratrol
PubMed ID: 32695229
Heartâfailure trial showed modest 6MWT improvement and reduced RBC aggregation helping exercise capacity.
- Angiographic and Clinical Outcomes After Treatment of Femoro-Popliteal Lesions with a Novel Paclitaxel-Matrix-Coated Balloon Catheter
PubMed ID: 28660441
Paclitaxelâresveratrol matrix-coated balloon in PAD improved walking distance and reduced revascularization vs POBA (functional improvement).
- Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women
PubMed ID: 28505227
Resveratrol added to exercise in older adults markedly increased muscle fiber area, strength/power and mitochondrial indicesâstrong exerciseârelated benefit.
- Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity
PubMed ID: 39182247
EGCG+resveratrol preserved fasting and postprandial fat oxidation and muscle oxidative capacity, which can support recovery/endurance.
Weight management (3)
- Efficacy of an orlistat-resveratrol combination for weight loss in subjects with obesity: A randomized controlled trial
PubMed ID: 27221771
6âmonth study showed orlistat+resveratrol led to greater weight loss than placebo, but resveratrol alone did not outperform placeboâcombination benefit likely.
- A randomized controlled trial comparing the efficacy of resveratrol combined with metformin versus resveratrol monotherapy in the management of polycystic ovary syndrome
PubMed ID: 40888876
PCOS trial reported BMI reductions over 6 months (noted stronger with combination), indicating weight-related benefit in that population.
- Treatment with combined resveratrol and myoinositol ameliorates endocrine, metabolic alterations and perceived stress response in women with PCOS: a double-blind randomized clinical trial
PubMed ID: 36169918
Resveratrol+myoâinositol arm in PCOS showed weight and BMI reductions (combination produced clinically relevant weight change).
Energy & Fatigue (3)
- Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women
PubMed ID: 28505227
Improved muscle strength and power with resveratrol+exercise may translate into perceived and functional energy/ability.
- The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans
PubMed ID: 26344014
28âday trial in healthy young adults reported reduced subjective fatigue across 28 daysâdirect human evidence for energy/fatigue benefit.
- Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial
PubMed ID: 33068691
Improved walking endurance and mitochondrial marker (citrate synthase) suggest energy benefits.
Skin health (3)
- Comparative Evaluation of Clinical Efficacy and Safety of Collagen Laminin-Based Dermal Matrix Combined With Resveratrol Microparticles (Dermalix) and Standard Wound Care for Diabetic Foot Ulcers
PubMed ID: 32131656
Resveratrolâloaded dermal matrix doubled wound closure rates and lowered inflammatory/oxidative markers in diabetic foot ulcers (strong local skin healing effect).
- Effect of Passion Fruit Seed Extract Rich in Piceatannol on the Skin of Women: A Randomized, Placebo-Controlled, Double-Blind Trial
PubMed ID: 29491276
Piceatannolârich extract improved skin hydration and reduced fatigue in a randomized trial (resveratrolârelated compound with skin benefits).
- Efficacy and safety of a topical skincare regimen containing CE Ferulic serum and resveratrol BE serum following ablative fractional CO(2) laser treatment: A prospective, randomized, split-face, controlled trial
PubMed ID: 38828801
Split-face RCT of topical CE Ferulic + RSV after laser showed faster healing, less erythema/pigmentation and increased hydrationâclear topical skin benefit.
Eye health (1)
- Effect of Resveratrol-Based Nutritional Supplement on Choroidal Thickness: A Pilot Study
PubMed ID: 26863155
Acute single-dose trial increased choroidal thickness, consistent with choroidal vasodilation relevant to ocular perfusion.
Similar by evidence
Supplements the same benefits carry qualifying findings for â a fact about the evidence graph, not a recommendation to swap.
Products with Resveratrol
Search all2512 products whose verified label declares Resveratrol â not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet â this is what the field is asking, not what it found.