Hesperidin
16 benefits mapped to clinical evidence across supplements.
Dose per serving from products
438 products in our catalogue print how much Hesperidin a serving holds.
Most common: 5 mg to 10 mg, 22% of 438 products.
| Dose per serving | Products |
|---|---|
| 1 mg or less | 15 |
| 1 mg to 2.5 mg | 9 |
| 2.5 mg to 5 mg | 87 |
| 5 mg to 10 mg | 98 |
| 10 mg to 25 mg | 74 |
| 25 mg to 50 mg | 60 |
| 50 mg to 100 mg | 41 |
| 100 mg to 250 mg | 35 |
| over 250 mg | 19 |
Dose per serving from research
38 study groups in 27 studies say how much Hesperidin participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 50% of 38 study groups.
| Daily dose | Study groups |
|---|---|
| 50 mg to 100 mg | 3 |
| 100 mg to 250 mg | 5 |
| 250 mg to 500 mg | 19 |
| 500 mg to 1 g | 10 |
| over 1 g | 1 |
Commonly used together
15 of 38 study groups took Hesperidin with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Diosmin | 3 |
Benefit Evidence
BPâ, blood flowâ
vein toneâ, +2.5mmHg
endothelial functionâ, inflammationâ
Tissue repair: +5.5% retention
Tissue repair: faster healing/bleeding â5.2%
Inflammation genes â3,422
CRP/ILâ6/TNFâα â
Adhesion markers â
BPâ, blood flowâ
vein toneâ, +2.5mmHg
endothelial functionâ, inflammationâ
Tissue repair: +5.5% retention
Tissue repair: faster healing/bleeding â5.2%
Research sources
Vascular health (18)
- Daflon 500 mg in the treatment of hemorrhoidal disease: a demonstrated efficacy in comparison with placebo
PubMed ID: 8203790
Large randomized trial: micronized flavonoid markedly reduced hemorrhoid symptom scores, attack incidence and duration vs placebo.
- Treatment of secondary lymphedema of the upper limb with CYCLO 3 FORT
PubMed ID: 8721977
Cyclo 3 Fort (including hesperidin methyl chalcone) reduced arm lymphedema volume vs placebo over 3 months (clinically meaningful).
- An open-label, randomised multicentre study comparing the efficacy and safety of CYCLO 3 FORT versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency
PubMed ID: 10811525
Cyclo 3 Fort improved venousâlymphatic symptoms and limb size better than comparator over 90 days (multicenter randomized study).
- An open-label, randomized multicenter study comparing the efficacy and safety of Cyclo 3 Fort versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency
PubMed ID: 10917578
Complementary report showing Cyclo 3 Fort superiority for venous/lymphatic symptoms and limbâsize maintenance (same trial series).
- A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility
PubMed ID: 8376915
Wellâpowered doubleâblind RCT: diosmin/hesperidin produced large, clinically meaningful increases in capillary resistance vs placebo.
- Advantage of a micronized flavonoidic fraction (Daflon 500 mg) in comparison with a nonmicronized diosmin
PubMed ID: 8203783
Micronized flavonoid improved CVI clinical symptoms and plethysmographic venous parameters vs nonmicronized diosmin (randomized trial).
- Controlled studies of Daflon 500 mg in chronic venous insufficiency
PubMed ID: 8203786
Pooled randomized trials: micronized flavonoid consistently lowered venous capacitance/distensibility and improved emptying (robust hemodynamic evidence).
- Efficacy of Daflon 500 mg in the treatment of lymphedema (secondary to conventional therapy of breast cancer)
PubMed ID: 8995350
In postâbreastâcancer lymphedema subgroup, flavonoid improved lymphatic measuresâevidence for lymph/venous function in severe cases.
- [Analysis of surgical procedures on the vena saphena magna in the Czech Republic and an effect of Detralex during its stripping]
PubMed ID: 16218350
Perioperative Detralex (diosmin+hesperidin) reduced postoperative pain, analgesic need and hematoma after saphenous vein stripping (clinical perioperative venous benefit).
- Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study
PubMed ID: 16708123
Measured capillary filtration and skin flux in CVI trial; hesperidinâcontaining product produced some capillary/microcirculatory changes (comparative result).
- [On advisability of perioperative phleboprotection in endovascular treatment of lower in varicose disease: first initial results of the decision study]
PubMed ID: 22929677
Large multicenter RCT: perioperative Detralex (diosmin+hesperidin) improved VCSS and CIVIQâ14 after endovenous varicose treatment (strong venous evidence).
- Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial
PubMed ID: 23761871
Randomized trial: diosmin+hesperidin increased frequency of clinically relevant limbâvolume reduction and improved QoL in chronic venous disease.
- Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial
PubMed ID: 25893991
Tripleâblind RCT in acute hemorrhoids (venous pathology) showed reduced pain/bleeding and faster resolution with diosmin/troxerutin/hesperidin.
- Effect of Pycnogenol on the Healing of Venous Ulcers
PubMed ID: 27521821
Small RCT: diosmin/hesperidin had comparable adjuvant effect on venous ulcer healing to Pycnogenol (venous wound context).
- [Adjuvant phlebotrophic therapy and its effect on anti-inflammatory response after sclerotherapy]
PubMed ID: 27935886
Detralex periâprocedural reduced histamine and inflammatory markers that can influence capillary permeability (supports capillary integrity).
- Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I-III degree hemorroidal disease: a double-blind multicenter prospective comparative study
PubMed ID: 29934701
Flavonoid mix including hesperidin reduced hemorrhoidal bleeding (venous symptom improvement) with similar efficacy to comparator.
- [Open prospective randomized study of the results of using Venarus in postthrombotic disease]
PubMed ID: 29688200
Venarus (diosmin+hesperidin) improved symptoms, venous tone and small ulcer healing in postâthrombotic disease (solid venous support).
- Venoactive drug treatment for patients with pelvic varicose veins: Results of the single-center, randomized, open-label study (VENOTREAT)
PubMed ID: 40855727
Large RCT in pelvic varicose veins: diosmin+hesperidin combo produced rapid and large pain reductions (venous disease benefit).
Blood circulation (11)
- Advantage of a micronized flavonoidic fraction (Daflon 500 mg) in comparison with a nonmicronized diosmin
PubMed ID: 8203783
Micronized flavonoid improved plethysmographic venous parameters and symptoms in CVI (hemodynamic and clinical evidence).
- Controlled studies of Daflon 500 mg in chronic venous insufficiency
PubMed ID: 8203786
Pooled trials of micronized flavonoid consistently lowered venous capacitance/distensibility and improved emptying (hemodynamic evidence).
- Laser Doppler and transcutaneous oximetry: modern investigations to assess drug efficacy in chronic venous insufficiency
PubMed ID: 8748889
Small CVI study showed modest increases in transcutaneous oxygen and decreases in CO2âobjective circulation improvements.
- Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study
PubMed ID: 16708123
CVI trial: diosmin+hesperidin (Daflon) produced some microcirculatory and symptomatic changes vs comparator (circulation endpoint).
- Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study)
PubMed ID: 32661681
EOJ lowered SBP/PP and reduced ICAMâ1 and other vascular risk markers in hypertensive adults.
- Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency
PubMed ID: 16518519
Daflon gave modest QoL improvements in CVI (venous/circulatory disease context).
- Micronized purified flavonoid fraction in pretreating CABG patients
PubMed ID: 20401289
Preop Daflon lowered cardiac injury markers postâCABGâsuggests perioperative circulatory/organ protection (small RCT).
- [On advisability of perioperative phleboprotection in endovascular treatment of lower in varicose disease: first initial results of the decision study]
PubMed ID: 22929677
Perioperative Detralex (diosmin+hesperidin) improved clinical severity scores after endovenous treatment (circulatory/venous outcomes).
- [Adjuvant phlebotrophic therapy and its effect on anti-inflammatory response after sclerotherapy]
PubMed ID: 27935886
Detralex periâprocedural use lowered systemic inflammatory markers that relate to microcirculatory function.
- [Open prospective randomized study of the results of using Venarus in postthrombotic disease]
PubMed ID: 29688200
Venarus (diosmin+hesperidin) improved symptoms and venous tonicity in postâthrombotic disease (microcirculatory/venous support).
- 8 weeks of 2S-hesperidin prevents a decrease in pO(2) at submaximal intensity in amateur cyclists in off-season: randomized controlled trial
PubMed ID: 36857626
Supplementation prevented a drop in submaximal pO2 and altered CO2/tCO2, indicating effects on oxygen delivery/handling relevant to circulation.
Tissue repair (11)
- Treatment of secondary lymphedema of the upper limb with CYCLO 3 FORT
PubMed ID: 8721977
Cyclo 3 Fort reduced lymphedema volume over 3 monthsârelevant to tissue fluid balance and repair resolution.
- Effect of Pycnogenol on the Healing of Venous Ulcers
PubMed ID: 27521821
Venous ulcer healing trial: diosmin/hesperidin had adjuvant effect on ulcer area reduction comparable to Pycnogenol (wound healing context).
- Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial
PubMed ID: 25893991
Diosmin/troxerutin/hesperidin sped resolution of edema/thrombosis and reduced persistence of symptoms in acute hemorrhoids (strong tissue/lesion repair signal).
- A randomized, controlled clinical pilot study comparing three types of compression therapy to treat venous leg ulcers in patients with superficial and/or segmental deep venous reflux ï»ż
PubMed ID: 23934375
Venous ulcer study: all received diosmin/hesperidin; healing rates depended on compression modality but overall wound healing occurred (confounded by design).
- Clinical effectiveness of a highly standardized and bioavailable mixture of flavonoids and triterpenes in the management of acute hemorroidal crisis
PubMed ID: 22069954
Emospid (flavonoid/triterpene) produced rapid, large improvements in hemorrhoid bleeding/pain and gradeâsupports tissue resolution in venous lesions.
- Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids: randomized controlled trial
PubMed ID: 10813126
Detralex+fiber shortened time to stop hemorrhoidal bleeding and lowered 6âmonth recurrence (accelerated tissue/hemostatic recovery).
- Benefit of a 2-month treatment with a micronized, purified flavonoidic fraction on venous ulcer healing. A randomized, double-blind, controlled versus placebo trial
PubMed ID: 9477041
Multicenter RCT replicated accelerated healing of smaller venous ulcers when micronized flavonoid was added to standard care.
- Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients
PubMed ID: 8995348
Adding micronized flavonoid to compression/local care sped healing of smaller venous leg ulcers (â€10 cm) in RCTs.
- Prospective randomized controlled trial of a micronized flavonidic fraction to reduce bleeding after haemorrhoidectomy
PubMed ID: 7648143
Randomized trial after hemorrhoidectomy: micronized flavonoid reduced postoperative bleeding from ~6% to ~1%âclinically important tissueârepair benefit.
- Daflon 500 mg in the treatment of hemorrhoidal disease: a demonstrated efficacy in comparison with placebo
PubMed ID: 8203790
Micronized flavonoid markedly reduced hemorrhoid symptom burden and attack durationâsupports faster symptom/tissue recovery.
- Evaluation of the remineralization and antibacterial effect of natural versus synthetic materials on deep carious dentin: A randomized controlled trial
PubMed ID: 37023336
Clinical trial in treated deep caries assessed remineralization (radiodensity) and bacterial counts after hesperidin application; modest radiodensity increase but no significant antibacterial effectâdirect tissue repair endpoint measured.
Inflammation (10)
- Effectiveness of EriominÂź in managing hyperglycemia and reversal of prediabetes condition: A double-blind, randomized, controlled study
PubMed ID: 31183921
Marked reductions in hsCRP, ILâ6, TNFâα and increases in adiponectin across a large RCT indicate strong antiâinflammatory effects.
- The Effect of a Citrus and Pomegranate Complex on Physical Fitness and Mental Well-Being in Healthy Elderly: A Randomized Placebo-Controlled Trial
PubMed ID: 36156675
Decrease in MDA indicates lowered oxidative/inflammatory stress after 4 weeks in older adults.
- [Adjuvant phlebotrophic therapy and its effect on anti-inflammatory response after sclerotherapy]
PubMed ID: 27935886
Periâsclerotherapy RCT: Detralex markedly lowered CRP, histamine and ILâ1 (strong antiâinflammatory biomarker reductions).
- Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial
PubMed ID: 29468764
T2D RCT: hesperidin reduced ILâ6 and hsâCRP alongside BP and antioxidant gains (human antiâinflammatory evidence).
- The effect of hesperidin supplementation on metabolic profiles in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 31844967
MetS RCT: significant TNFâα reduction with hesperidin (clear inflammatory marker improvement).
- Evaluation of a preemptive intervention regimen with hesperidin methyl chalcone in delayed-onset muscle soreness in young adults: a randomized, double-blinded, and placebo-controlled trial study
PubMed ID: 37119360
Hesperidin methyl chalcone reduced muscleâdamage markers (CPK) and pain after exercise, indicating antiâinflammatory/analgesic effect.
- Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals
PubMed ID: 27797708
2Sâhesperidin reduced adhesion molecules (sVCAMâ1/sICAMâ1) and prevented postprandial endothelial dysfunction in a subgroup.
- Hesperidin supplementation modulates inflammatory responses following myocardial infarction
PubMed ID: 25757593
600 mg/day hesperidin reduced Eâselectin and increased adiponectin in postâMI patients (antiâinflammatory/vasoprotective markers).
- Effect of the consumption of hesperidin in orange juice on the transcriptomic profile of subjects with elevated blood pressure and stage 1 hypertension: A randomized controlled trial (CITRUS study)
PubMed ID: 34800819
EOJ downregulated multiple proinflammatory and insulinâresistance linked genes after 12 weeks.
- Effects of Hesperidin Consumption on the Cardiovascular System in Pre- and Stage 1 Hypertensive Subjects: Targeted and Non-Targeted Metabolomic Approaches (CITRUS Study)
PubMed ID: 34272817
Metabolomic changes with OJ/EOJ suggested reduced inflammatory pathway activity and correlated with lowered systolic BP.
Antioxidant (6)
- The Effect of a Citrus and Pomegranate Complex on Physical Fitness and Mental Well-Being in Healthy Elderly: A Randomized Placebo-Controlled Trial
PubMed ID: 36156675
CPC reduced plasma MDA (classic oxidative stress marker) vs placebo in older adults.
- A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial
PubMed ID: 37685975
Significant ~10% reduction in plasma methylglyoxal (a reactive glycating/oxidative metabolite) after 4 weeks.
- In vivo immunomodulatory effects of plant flavonoids in lipopolysaccharide-challenged broilers
PubMed ID: 27079952
Broiler study: hesperidin increased TAOC and SOD and decreased MDA (animal antioxidant data).
- Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double-Blind Placebo-Controlled Clinical Trial
PubMed ID: 28805022
RCT in T2D: 500 mg/day hesperidin increased TAC and reduced 8âOHDG and MDA significantly (strong human antioxidant endpoints).
- Effectiveness of EriominÂź in managing hyperglycemia and reversal of prediabetes condition: A double-blind, randomized, controlled study
PubMed ID: 31183921
Citrusâflavonoid supplement increased antioxidant capacity and reduced oxidative markers (MDA/AGEs reported in other combo studies).
- Effects of Hesperidin Consumption on the Cardiovascular System in Pre- and Stage 1 Hypertensive Subjects: Targeted and Non-Targeted Metabolomic Approaches (CITRUS Study)
PubMed ID: 34272817
OJ/EOJ intake produced metabolomic shifts consistent with antiâoxidant pathways and increased hesperetin metabolites.
Cholesterol (7)
- Flaxseed and/or hesperidin supplementation in metabolic syndrome: an open-labeled randomized controlled trial
PubMed ID: 32296931
MetS trial: hesperidin reduced serum triglycerides significantly and reduced MetS prevalence when combined with flaxseed.
- The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: AÂ Randomized Controlled Trial
PubMed ID: 35946912
In diabetic metabolicâsyndrome patients, hesperidin±diosmin reduced triglycerides and LDL (withinâgroup improvements reported).
- Hesperidin supplementation modulates inflammatory responses following myocardial infarction
PubMed ID: 25757593
600 mg/day hesperidin increased HDL in myocardial infarction patients (favorable lipid change).
- Hesperidin improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled, double-blind clinical trial
PubMed ID: 31264313
1 g/day hesperidin for 12 weeks in NAFLD patients significantly lowered total cholesterol versus placebo.
- Improved HDL, LDL and total cholesterol levels following a 3-month administration of Mentha spicata leaf extract and Amaranthus caudatus seed flour extracts, flavonoids and B vitamins. A placebo-controlled, double-blind, randomized clinical trial
PubMed ID: 41519619
Placeboâcontrolled RCT of a flavonoid supplement including hesperidin showed significant LDL and total cholesterol reductions and HDL increase over 3 months; product was multiâingredient so attribution to hesperidin is partial.
- Concomitant use of tea catechins affects absorption and serum triglyceride-lowering effects of monoglucosyl hesperidin
PubMed ID: 34606551
Monoglucosyl hesperidin + green tea lowered fasting TG (~â30 mg/dL) in small human study (combination product).
- The effect of hesperidin supplementation on metabolic profiles in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 31844967
MetS RCT: 1 g/day hesperidin significantly lowered triglycerides (~â49 mg/dL) (lipid improvement).
Cell health (6)
- Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double-Blind Placebo-Controlled Clinical Trial
PubMed ID: 28805022
T2D RCT: decreased oxidative DNA damage (8âOHDG) and lipid peroxidation, supporting cellular protection.
- Hesperidin improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled, double-blind clinical trial
PubMed ID: 31264313
Hepatic enzyme reductions and reduced hepatic steatosis in NAFLD indicate improved cellular (hepatic) health.
- A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial
PubMed ID: 37685975
Significant ~10% reduction in plasma methylglyoxal (MGO), a cellular glycating/toxic metaboliteâdirect biochemical support for cellular protection.
- The Effect of a Citrus and Pomegranate Complex on Physical Fitness and Mental Well-Being in Healthy Elderly: A Randomized Placebo-Controlled Trial
PubMed ID: 36156675
Lowered MDA (oxidative damage marker) supports reduced cellular oxidative stress in older adults.
- Effects of Hesperidin Consumption on the Cardiovascular System in Pre- and Stage 1 Hypertensive Subjects: Targeted and Non-Targeted Metabolomic Approaches (CITRUS Study)
PubMed ID: 34272817
Metabolomic shifts after hesperidin intake indicated changes in pathways tied to reduced inflammation/oxidation at the cellular level.
- Effectiveness of EriominÂź in managing hyperglycemia and reversal of prediabetes condition: A double-blind, randomized, controlled study
PubMed ID: 31183921
Citrusâflavonoid supplementation improved oxidative stress markers, inflammatory profile and GLPâ1âbroad cellular health signals.
Immune support (4)
- Effectiveness of EriominÂź in managing hyperglycemia and reversal of prediabetes condition: A double-blind, randomized, controlled study
PubMed ID: 31183921
Citrusâflavonoid supplement reduced inflammatory markers (hsCRP, ILâ6, TNFâα) and increased adiponectin, implying immune/inflammatory benefit.
- Effect of the consumption of hesperidin in orange juice on the transcriptomic profile of subjects with elevated blood pressure and stage 1 hypertension: A randomized controlled trial (CITRUS study)
PubMed ID: 34800819
Hesperidinâenriched juice downregulated several proinflammatory/immune genes after 12 weeks.
- Individual and combined effects of genistein and hesperidin on immunity and intestinal morphometry in lipopolysacharide-challenged broiler chickens
PubMed ID: 24974391
Broiler LPS challenge: dietary hesperidin improved humoral/mucosal immunity and immune markers (animal data).
- In vivo immunomodulatory effects of plant flavonoids in lipopolysaccharide-challenged broilers
PubMed ID: 27079952
Large poultry study: hesperidin increased TAOC/SOD and enhanced antibody and mucosal immune indices (animal evidence).
Blood pressure (4)
- Effects of Hesperidin Consumption on the Cardiovascular System in Pre- and Stage 1 Hypertensive Subjects: Targeted and Non-Targeted Metabolomic Approaches (CITRUS Study)
PubMed ID: 34272817
OJ/EOJ increased hesperetin metabolites and metabolomic changes that correlated with decreased systolic blood pressure after 12 weeks.
- Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study)
PubMed ID: 32661681
Large 12âweek trial: orange juice (esp. hesperidinâenriched) produced doseâdependent, clinically meaningful SBP reductions (~6â7 mmHg).
- Flaxseed and/or hesperidin supplementation in metabolic syndrome: an open-labeled randomized controlled trial
PubMed ID: 32296931
MetS RCT: 1 g/day hesperidin significantly lowered SBP (~â5.7 mmHg vs control).
- Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial
PubMed ID: 29468764
T2D RCT: 500 mg/day hesperidin produced a modest but significant SBP reduction (~3.7 mmHg).
Healthy aging (5)
- The Effectiveness of Hesperidin, Diosmin and Proanthocyanidins Nutritional Supplementation on Cognitive and Motor Functions in Older Adults: A Pilot Randomized Control Study
PubMed ID: 40694049
Small crossover multiâingredient supplement (contains hesperidin) improved attention and reduced fall riskâpilot evidence for functional aging support.
- A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial
PubMed ID: 37685975
Reduction in methylglyoxal (a driver of protein glycation and aging processes) supports healthyâaging mechanisms.
- The Effect of a Citrus and Pomegranate Complex on Physical Fitness and Mental Well-Being in Healthy Elderly: A Randomized Placebo-Controlled Trial
PubMed ID: 36156675
Older adults showed improved handgrip strength and reduced oxidative marker over 4 weeksâfunctional and biomarker evidence relevant to aging.
- Effectiveness of EriominÂź in managing hyperglycemia and reversal of prediabetes condition: A double-blind, randomized, controlled study
PubMed ID: 31183921
Multimodal metabolic, antiâinflammatory and antioxidant benefits (including reversion of prediabetes in some) support healthyâaging biology.
- Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults
PubMed ID: 25733635
8 weeks highâflavanone orange juice improved global cognitive function in healthy older adultsâdirect healthyâaging cognitive evidence.
Exercise recovery (5)
- 8 weeks of 2S-hesperidin prevents a decrease in pO(2) at submaximal intensity in amateur cyclists in off-season: randomized controlled trial
PubMed ID: 36857626
Randomized trial in cyclists showed physiological effects (preserved submaximal pO2, increased CO2/tCO2) relevant to exercise performance/recovery.
- Effects of 8 Weeks of 2S-Hesperidin Supplementation on Performance in Amateur Cyclists
PubMed ID: 33371483
8 weeks 2Sâhesperidin improved cycling FTP and max power and preserved aerobic markersâdirect ergogenic/exercise recovery evidence.
- 8 weeks of 2S-Hesperidin supplementation improves muscle mass and reduces fat in amateur competitive cyclists: randomized controlled trial
PubMed ID: 33977947
8 weeks 2Sâhesperidin in cyclists reduced body fat and increased muscle massâsupports recovery/physical adaptation.
- The effect of citrus flavonoid extract supplementation on anaerobic capacity in moderately trained athletes: a randomized controlled trial
PubMed ID: 33407631
Large RCT: citrus (hesperidinârich) extract produced clear, doseârelated increases in anaerobic average and peak cycling power.
- Evaluation of a preemptive intervention regimen with hesperidin methyl chalcone in delayed-onset muscle soreness in young adults: a randomized, double-blinded, and placebo-controlled trial study
PubMed ID: 37119360
Hesperidin methyl chalcone reduced CPK, palpation pain and increased repetitions after intense exercise (muscleâdamage/recovery benefits).
Blood sugar (4)
- The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: AÂ Randomized Controlled Trial
PubMed ID: 35946912
RCT in diabetics with metabolic syndrome: hesperidin ± diosmin produced withinâgroup reductions in fasting glucose, best with combination.
- The effect of hesperidin supplementation on metabolic profiles in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 31844967
12âweek RCT in MetS: 1 g/day hesperidin significantly lowered fasting glucose vs placebo (solid human metabolic evidence).
- The efficacy of flaxseed and hesperidin on non-alcoholic fatty liver disease: an open-labeled randomized controlled trial
PubMed ID: 32647367
12âweek hesperidin (±flaxseed) in NAFLD improved fasting glucose and HOMAâIR versus lifestyle control.
- Effectiveness of EriominÂź in managing hyperglycemia and reversal of prediabetes condition: A double-blind, randomized, controlled study
PubMed ID: 31183921
Large randomized trial of a citrusâflavonoid supplement (EriominÂź) improved fasting glucose, HbA1c, HOMAâIR and reversed prediabetes in a subset.
Energy & Fatigue (4)
- Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes
PubMed ID: 21537493
In combination (pâsynephrine + naringin + 100 mg hesperidin) increased resting metabolic rate significantly without raising HR/BP, indicating an energyârelated effect (combination dependent).
- Effects of 8 Weeks of 2S-Hesperidin Supplementation on Performance in Amateur Cyclists
PubMed ID: 33371483
Improved cycling power/endurance metrics indicate ergogenic/energyârelated benefit during exercise.
- The effect of citrus flavonoid extract supplementation on anaerobic capacity in moderately trained athletes: a randomized controlled trial
PubMed ID: 33407631
Improved anaerobic power suggests an ergogenic/energy benefit during highâintensity exercise (direct performance evidence).
- Evaluation of a preemptive intervention regimen with hesperidin methyl chalcone in delayed-onset muscle soreness in young adults: a randomized, double-blinded, and placebo-controlled trial study
PubMed ID: 37119360
Improved repetitions to failure after supplementation indicates better shortâterm performance/energy availability (small trial, derivative compound).
Brain health (3)
- The Effect of a Citrus and Pomegranate Complex on Physical Fitness and Mental Well-Being in Healthy Elderly: A Randomized Placebo-Controlled Trial
PubMed ID: 36156675
Citrus+pomegranate complex produced a small but significant improvement in a cognitive facet (thinking/learning/memory) after 4 weeks in older adults.
- Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults
PubMed ID: 25733635
8 weeks of highâflavanone orange juice improved global cognitive function in healthy older adults (direct cognitive endpoint).
- The Effectiveness of Hesperidin, Diosmin and Proanthocyanidins Nutritional Supplementation on Cognitive and Motor Functions in Older Adults: A Pilot Randomized Control Study
PubMed ID: 40694049
Small crossover human study: multiâingredient supplement containing hesperidin improved attention and memory measures (pilot cognitive benefit).
Gut health (2)
- Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion
PubMed ID: 18710603
Pharmacokinetic evidence that hesperidin is largely absorbed late (colon) with large interindividual variabilityârelevant to colonic metabolism/microbiota interactions.
- Individual and combined effects of genistein and hesperidin on immunity and intestinal morphometry in lipopolysacharide-challenged broiler chickens
PubMed ID: 24974391
Broiler LPS model showed improved intestinal morphometry and intraepithelial lymphocytes with dietary hesperidin (animal gut evidence).
Allergy relief (1)
- [Adjuvant phlebotrophic therapy and its effect on anti-inflammatory response after sclerotherapy]
PubMed ID: 27935886
Detralex periâprocedure significantly lowered histamine levels (marker linked to allergic responses) along with other inflammatory markers.
Similar by evidence
Supplements the same benefits carry qualifying findings for â a fact about the evidence graph, not a recommendation to swap.
Products with Hesperidin
Search all681 products whose verified label declares Hesperidin â not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet â this is what the field is asking, not what it found.