Ubiquinol
15 benefits mapped to clinical evidence across supplements.
Dose per serving from products
420 products in our catalogue print how much Ubiquinol a serving holds.
Most common: 50 mg to 100 mg, 46% of 420 products.
| Dose per serving | Products |
|---|---|
| 10 mg or less | 13 |
| 10 mg to 25 mg | 15 |
| 25 mg to 50 mg | 36 |
| 50 mg to 100 mg | 192 |
| 100 mg to 250 mg | 77 |
| 250 mg to 500 mg | 16 |
| 500 mg to 1 g | 71 |
Dose per serving from research
29 study groups in 25 studies say how much Ubiquinol participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 100 mg to 250 mg, 45% of 29 study groups.
| Daily dose | Study groups |
|---|---|
| 50 mg or less | 1 |
| 50 mg to 100 mg | 5 |
| 100 mg to 250 mg | 13 |
| 250 mg to 500 mg | 6 |
| 500 mg to 1 g | 4 |
Benefit Evidence
Heart function +7–8%
Stress/inflammation protection
Energy biomarkers −
Endothelial function +FMD
Lower injury/oxidation markers
Better circulation +LVEF
Endothelial function +FMD
Lower injury/oxidation markers
Better circulation +LVEF
Research sources
Antioxidant (7)
- Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects
PubMed ID: 32741773
Supplementation reduced percent oxidized CoQ10 and systemic oxidative status perioperatively, supporting antioxidant effects.
- Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial
PubMed ID: 32326664
Dose-dependent increase in total CoQ10 and decrease in oxidized CoQ10% plus improved lipoprotein antioxidant resistance in dyslipidemic adults.
- The effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study
PubMed ID: 22595020
Diabetic neuropathy trial reduced lipid peroxidation and improved nerve function with ubiquinone.
- Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial
PubMed ID: 26342738
RCT in RA decreased MDA (oxidative stress) alongside lower TNF-α after CoQ10 supplementation.
- Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial
PubMed ID: 27193497
Large randomized trial showed consistent reductions in multiple oxidative-stress markers and improved antioxidant defenses after short-term ubiquinol.
- Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial
PubMed ID: 28684614
APS crossover trial reduced peroxides and improved mitochondrial markers and endothelial oxidative status.
- Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial
PubMed ID: 29936921
Diabetes trial increased antioxidant enzymes (catalase, GPx) and reduced HbA1c, supporting antioxidant and metabolic effects.
Energy & Fatigue (5)
- Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome
PubMed ID: 27125909
CFS randomized trial (150 mg/day) produced improvements in fatigue-related symptoms and autonomic function.
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
Improved lactate/ATP ratio and patient vigor in HFpEF indicate enhanced cellular energy metabolism with ubiquinol.
- Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise
PubMed ID: 32041223
Preservation of RBC and hemoglobin after strenuous exercise would be expected to reduce post‑exercise fatigue.
- Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise
PubMed ID: 32797125
Increases in metabolic regulator PGC‑1α after strenuous exercise suggest influence on mitochondrial biogenesis/energy regulation.
- Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial
PubMed ID: 29936921
In type 2 diabetes liquid ubiquinol reduced HbA1c and increased antioxidant enzymes—metabolic improvements that align with energy metabolism support.
Stress resilience (4)
- Effect of ubiquinol on electrophysiology during high-altitude acclimatization and de-acclimatization: A substudy of the Shigatse CARdiorespiratory fitness (SCARF) randomized clinical trial
PubMed ID: 38307422
Ubiquinol during high‑altitude exposure improved ECG repolarization indices and preserved maximal exercise heart rate—evidence it helps physiologic stress responses.
- Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise
PubMed ID: 32041223
Attenuation of exercise‑induced inflammatory responses and preservation of hematologic indices indicate improved resilience to physical stress.
- Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects
PubMed ID: 32741773
Perioperative reduction in myocardial injury markers suggests better resilience to surgical/cardiac stress.
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
Improved symptoms and cellular energy biomarkers in HFpEF imply improved physiological tolerance to chronic cardiac stress.
Heart health (4)
- Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study
PubMed ID: 17824295
HF patients in a ubiquinol+L-carnitine study had improved 6-min walk and symptoms, indicating cardiovascular functional benefit (combination product).
- Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects
PubMed ID: 32741773
Perioperative ubiquinol reduced postoperative troponin/CK‑MB and improved 6‑month LVEF in AVR patients—clear myocardial protection signal.
- Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial
PubMed ID: 32326664
Improved endothelial function (FMD) and increased NO metabolites in dyslipidemic adults support vascular components of cardiac support.
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
Randomized trial in HFpEF showed large symptom (KCCQ), EF and biomarker improvements with high‑dose ubiquinol—strong evidence for cardiac benefit.
Blood circulation (3)
- Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects
PubMed ID: 32741773
Perioperative reduction in oxidative CoQ10 and cardiac injury markers with improved LVEF suggests improved myocardial perfusion/outcomes.
- Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial
PubMed ID: 28684614
APS crossover RCT reported improved endothelial function and reductions in prothrombotic mediators after ubiquinol.
- Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial
PubMed ID: 32326664
Randomized trial showed dose‑dependent, clinically meaningful improvements in flow‑mediated dilation and increased NO metabolites—direct evidence of improved endothelial function/circulation.
Fertility (2)
- Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study
PubMed ID: 22704112
Large randomized double-blind trial: 200 mg/day ubiquinol for 26 weeks significantly improved sperm density, motility and morphology versus placebo.
- Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial
PubMed ID: 18395716
Six-month RCT: oral CoQ10 increased seminal CoQ10/ubiquinol and improved sperm motility in infertile men (placebo-controlled).
Vitality (2)
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
Large improvements in patient‑reported health status (KCCQ) and vigor in HFpEF indicate meaningful gains in perceived vitality.
- Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise
PubMed ID: 32041223
Broad physiologic benefits after strenuous exercise (inflammation, RBCs, angiogenic factors) translate to improved functional resilience and vitality.
Illness recovery (2)
- Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study
PubMed ID: 17824295
HF patients given ubiquinol+L-carnitine improved 6-min walk (+73 m) and symptoms, indicating faster functional recovery (combination product).
- Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise
PubMed ID: 32041223
Supplementation attenuated exercise-induced inflammatory responses and prevented post-exercise drops in RBC indices—physiologic changes consistent with improved recovery.
Immune support (2)
- Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial
PubMed ID: 26342738
RCT in RA showed decreased TNF-α and oxidative marker (MDA), supporting anti-inflammatory/immune-modulating effects.
- Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise
PubMed ID: 32041223
Modulated systemic cytokine responses to strenuous exercise (reduced pro-inflammatory, increased IL‑10) indicating immunomodulatory effects.
Endurance (2)
- Effect of ubiquinol on electrophysiology during high-altitude acclimatization and de-acclimatization: A substudy of the Shigatse CARdiorespiratory fitness (SCARF) randomized clinical trial
PubMed ID: 38307422
Preservation of peak exercise heart rate at altitude indicates potential to sustain performance under physiologic stress.
- Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise
PubMed ID: 32041223
Preservation of RBC parameters and increases in angiogenic signals after supplementation during strenuous exercise support improved oxygen-carrying capacity and endurance potential.
Mental clarity (2)
- Coenzyme Q10 in the Treatment of Attention Deficit Hyperactivity Disorder in Children: A Randomized Controlled Trial
PubMed ID: 34819012
Significant improvement in ADHD symptoms (attention/hyperactivity) with ubiquinol add‑on supports cognitive/behavioral benefit.
- Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson's disease
PubMed ID: 26054881
In PD patients with wearing-off, 300 mg/day ubiquinol improved total UPDRS (symptom score), suggesting symptomatic CNS benefit in that subgroup.
Healthy aging (1)
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
In older HFpEF patients ubiquinol improved symptoms, EF and cellular‑energy biomarkers—clinically relevant benefits in an aging population.
Mood balance (1)
- Coenzyme Q10 in the Treatment of Attention Deficit Hyperactivity Disorder in Children: A Randomized Controlled Trial
PubMed ID: 34819012
In children with ADHD, add‑on ubiquinol produced substantial symptom reductions on parent‑rated scales, implying central nervous system/behavioral benefit.
Cell health (1)
- Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects
PubMed ID: 32741773
Perioperative ubiquinol reduced troponin/CK‑MB (markers of myocardial injury) and improved LVEF at 6 months—consistent with reduced cellular injury and enhanced repair/functional recovery.
Blood pressure (1)
- Effect of reduced coenzyme Q10 (ubiquinol) supplementation on blood pressure and muscle damage during kendo training camp: a double-blind, randomized controlled study
PubMed ID: 25369277
Short-term 600 mg/day ubiquinol lowered diastolic blood pressure during an intense training camp in athletes (randomized double-blind).
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Ubiquinol
Search all457 products whose verified label declares Ubiquinol — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.