Lysine
18 benefits mapped to clinical evidence across supplements.
Dose per serving from products
1,233 products in our catalogue print how much Lysine a serving holds.
Most common: 1 g to 2.5 g, 36% of 1,233 products.
| Dose per serving | Products |
|---|---|
| 25 mg or less | 34 |
| 25 mg to 50 mg | 61 |
| 50 mg to 100 mg | 49 |
| 100 mg to 250 mg | 115 |
| 250 mg to 500 mg | 170 |
| 500 mg to 1 g | 247 |
| 1 g to 2.5 g | 442 |
| 2.5 g to 5 g | 101 |
| over 5 g | 14 |
Dose per serving from research
40 study groups in 10 studies say how much Lysine participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 10 mg/kg to 25 mg/kg, 43% of 40 study groups.
| Daily dose | Study groups |
|---|---|
| 2.5 mg/kg or less | 1 |
| 2.5 mg/kg to 5 mg/kg | 3 |
| 5 mg/kg to 10 mg/kg | 4 |
| 10 mg/kg to 25 mg/kg | 17 |
| 25 mg/kg to 50 mg/kg | 11 |
| 50 mg/kg to 100 mg/kg | 4 |
Commonly used together
21 of 60 study groups took Lysine with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Arginine | 5 |
Benefit Evidence
Tissue repair â healing
Tissue repair +34% closure
Tissue repair â bleeding
Power recovery +21-24%
Protein balance â50 to +29
Lysine â22%, creatine +98%
Tissue repair â healing
Tissue repair +34% closure
Tissue repair â bleeding
Power recovery +21-24%
Protein balance â50 to +29
Lysine â22%, creatine +98%
Research sources
Growth support (34)
- Evaluation of standardized ileal digestible lysine requirement of nursery pigs from seven to fourteen kilograms
PubMed ID: 23255816
Large pig growth trials: increasing digestible lysine improved ADG and feed efficiency up to a defined requirement â strong animal evidence for growth support.
- Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial
PubMed ID: 30649163
Large RCT in infants: multi-nutrient SQ-LNS containing lysine modestly improved linear growth and locomotor development â supports growth when provided as part of multi-nutrient supplement.
- Estimates of the optimum dietary ratio of standardized ileal digestible valine to lysine for eight to twenty-five kilograms of body weight pigs
PubMed ID: 19359510
Pig trials clearly show optimal Val:Lys ratios improve ADG and feed efficiencyâstrong animal evidence that lysine balance supports growth.
- Estimation of the standardized ileal digestible valine-to-lysine ratio in 13- to 32-kilogram pigs
PubMed ID: 21057092
Pig feeding experiments again demonstrate pronounced growth/performance gains with optimal Val:Lys (~65%), implicating lysine's central role in growth (animal model).
- Valine needs in starting and growing Cobb (500) broilers
PubMed ID: 23243242
Large broiler studies found improved weight gain/FCR with higher digestible Val:Lys ratiosârobust poultry evidence for growth-support effects of lysine-balanced diets.
- Effects of lysine intake during late gestation and lactation on blood metabolites, hormones, milk composition and reproductive performance in primiparous and multiparous sows
PubMed ID: 18547756
Higher lysine intake in sows increased milk protein and body condition and raised reproductive hormonesâsupports growth/reproductive performance in animals.
- Estimation of the standardized ileal digestible lysine requirement for primiparous pregnant sows
PubMed ID: 26174182
Controlled dietary SID lysine optimization in pregnant gilts improved maternal weight gain and colostrumâstrong animal evidence for growth/nutritional requirement.
- The effect of dietary methionine and its relationship to lysine on growth performance of the segregated early-weaned pig
PubMed ID: 8655442
Piglet trial established methionine:lysine ratio that maximized growth (clear animal nutrition evidence).
- Feedlot performance and carcass characteristics of Holstein steers as affected by source of dietary protein and level of ruminally protected lysine and methionine
PubMed ID: 8655422
Rumenâprotected lysine+methionine improved gain:feed by ~12% in finishing Holstein steersâclear animal growth support evidence.
- The use of synthetic lysine in the diet of lactating sows
PubMed ID: 9621951
Synthetic Lâlysine in lactating sow diets increased preweaning mortality and reduced litter growthâstrong evidence that lysine supplementation form/level influences offspring growth (adverse outcome).
- The lysine requirement of lactating primiparous sows
PubMed ID: 9581933
Sow study: digestible lysine reduced body protein loss and affected litter growth/secondâlitter size (animal reproduction/growth).
- The lysine requirement and ratio of total sulfur amino acids to lysine for chicks fed adequate or inadequate lysine
PubMed ID: 9565240
Young chicks: increasing dietary lysine clearly improved growth rate and feed efficiency (strong animal growth evidence).
- Nitrogen metabolism and growth performance of gilts fed standard corn-soybean meal diets or low-crude protein, amino acid-supplemented diets
PubMed ID: 12462259
Lowâprotein pig diets with crystalline lysine maintained growth except at very low CP; relevant to growth when protein limited.
- Lysine-fortified wheat flour improves the nutritional and immunological status of wheat-eating families in northern China
PubMed ID: 15214257
Child height and weight gains were significantly greater with lysineâfortified flourâdirect growth support evidence in humans.
- Lysine fortification of wheat flour improves selected indices of the nutritional status of predominantly cereal-eating families in Pakistan
PubMed ID: 15214256
Doubleâblind fortification improved children's growth (height/weight) in Pakistanâstrong human evidence.
- Estimation of the true ileal digestible lysine and sulfur amino acid requirement and comparison of the bioefficacy of 2-hydroxy-4-(methylthio)butanoic acid and DL-methionine in eleven- to twenty-six-kilogram nursery pigs
PubMed ID: 16775054
Very large swine trials showed doseâresponsive growth gains with increased dietary lysineârobust animal growth data.
- Evaluation of sex and lysine during the nursery period
PubMed ID: 17296765
Large nursery pig trial: increased dietary lysine consistently improved ADG and G:F across sitesâstrong evidence for growth support in animals.
- The effectiveness of quality protein maize in improving the nutritional status of young children in the Ethiopian highlands
PubMed ID: 20973462
Feeding quality-protein maize (higher lysine) prevented weight faltering in young children â direct growth-support evidence in humans.
- Effects of increasing lysine on carcass composition and cutting yields of immunologically castrated male pigs
PubMed ID: 21383034
Dietary lysine increased lean gain in growing pigs â strong animal evidence for growth-promoting role of lysine.
- Dietary lysine affects chickens from local Chinese pure lines and their reciprocal crosses
PubMed ID: 23687167
Chicken lines: higher dietary lysine increased growth and muscle weight and improved feed conversion (avian growth evidence).
- Utilization of crystalline or protein-bound lysine for growth and carcass traits of barrows and gilts fed individually or in groups
PubMed ID: 23881680
Raising SID lysine increased ADG and lean deposition in pigs â clear dose-dependent growth effect (animal model).
- Effect of diet composition and lysine supply on growth and body composition in juvenile turbot (Psetta maxima)
PubMed ID: 23930712
Juvenile turbot: lysine intake influenced growth and allowed estimation of lysine maintenance â aquatic growth evidence.
- Growth and haematological response of indigenous Venda chickens aged 8 to 13 weeks to varying dietary lysine to energy ratios
PubMed ID: 25495676
Large poultry trial: lysine:energy ratio manipulation changed intake and growth â species-specific but relevant to growth biology.
- Compensatory growth response and carcass quality after a period of lysine restriction in lean meat type barrows
PubMed ID: 24444364
Lysine restriction reduced daily gain and lean meat in pigs; later repletion partly recovered growth â indicates necessity for growth.
- Effects of standardized ileal digestible tryptophan: lysine ratio on growth performance of nursery pigs
PubMed ID: 26440171
Try:lys ratio experiments in nursery pigs defined lysine's central role in optimal growth/feed efficiency.
- The appropriate standardized ileal digestible tryptophan to lysine ratio improves pig performance and regulates hormones and muscular amino acid transporters in late finishing gilts fed low-protein diets
PubMed ID: 26020882
Adjusting Trp relative to Lys in lowâprotein pig diets improved ADG and growth hormones â growth modulation linked to lysine ratio.
- Dietary lysine requirement for 7-16Â kg pigs fed wheat-corn-soybean meal-based diets
PubMed ID: 26898636
Clear quantitative demonstration in pigs that increasing digestible lysine increases ADG and feed efficiency â strong growth support evidence in animals.
- Effect of a lysine depletion-repletion protocol on the compensatory growth of growing-finishing pigs
PubMed ID: 26812332
Lysine restriction reduced feed intake/growth; repletion partially restored growth â direct growth effect.
- Effect of feeding three lysine to energy diets on growth, body composition and age at puberty in replacement gilts
PubMed ID: 28711219
Higher dietary lysine increased growth rate and advanced puberty timing in gilts â strong growth/development signal.
- Estimation of lysine requirements for growing Japanese quails
PubMed ID: 28986922
Doseâresponse lysine effects on quail weight gain and breast yield â animal growth guidance.
- Effects of dietary protein-to-energy ratio on rate of growth, protein deposition and tissue composition of pure Iberian boars prior to extensive production
PubMed ID: 28380594
Digestible lysine requirement estimates provided for growing Iberian pigs â supports growth nutritional planning.
- Exercise combined with lysine-inositol vitamin B12 promotes height growth in children with idiopathic short stature
PubMed ID: 37245296
Randomized study in children with idiopathic short stature showed increased growth velocity and GHâaxis markers after lysineâinositolâB12 plus exercise (coâintervention confounds attribution).
- [The effect of consuming quality protein maize or conventional maize on the growth and morbidity of malnourished Nicaraguan children 1 to 5 years of age]
PubMed ID: 19368299
Qualityâprotein maize (higher lysine) produced measurable improvements in nutritional status of children â strong direct human nutritional evidence.
- Response surface and neural network models for performance of broiler chicks fed diets varying in digestible protein and critical amino acids from 11 to 17 days of age
PubMed ID: 21844277
Broiler trial directly defined optimal digestible lysine concentrations for maximal ADG and feed efficiencyâstrong evidence for lysine as a growthâlimiting amino acid (animal model).
Muscle growth (29)
- Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
PubMed ID: 15105032
HMB+Arg+Lys increased wholeâbody protein synthesis and strength in elderly (strong evidence for anabolic effect within combination).
- Metabolic plasticity of the gut microbiome in response to diets differing in glycemic load in a randomized, crossover, controlled feeding study
PubMed ID: 40619005
Direct enrichment of Lâlysine biosynthesis pathway implies increased potential supply of an essential amino acid needed for protein synthesis.
- [The effect of consuming quality protein maize or conventional maize on the growth and morbidity of malnourished Nicaraguan children 1 to 5 years of age]
PubMed ID: 19368299
Qualityâprotein maize (higher lysine & tryptophan) improved child nutritional status â direct evidence that increased lysine supports protein nutrition in humans.
- Dietary Lysine Requirements of Older Adults Stratified by Age and Sex
PubMed ID: 38735574
Direct IAAO determination of lysine requirements in older adultsâcritical data for protein synthesis/nutritional needs.
- Effects of dietary protein-to-energy ratio on rate of growth, protein deposition and tissue composition of pure Iberian boars prior to extensive production
PubMed ID: 28380594
Provided digestible lysine requirement estimates for Iberian pigs â directly relevant to dietary protein building.
- Estimation of lysine requirements for growing Japanese quails
PubMed ID: 28986922
Doseâresponse lysine affects carcass/breast yield in quail â protein deposition relevance.
- Effect of feeding three lysine to energy diets on growth, body composition and age at puberty in replacement gilts
PubMed ID: 28711219
Higher lysine increased ADG in gilts â supports protein accretion/growth.
- Short- and longer-term effects of feeding increased metabolizable protein with or without an altered amino acid profile to dairy cows immediately postpartum
PubMed ID: 28434720
Rumenâprotected lysine increased milk protein concentration in dairy cows â indicates protein synthesis role.
- Effect of a lysine depletion-repletion protocol on the compensatory growth of growing-finishing pigs
PubMed ID: 26812332
Lysine restriction lowered protein deposition; repletion partially restored deposition â direct protein building relevance.
- Dietary lysine requirement for 7-16Â kg pigs fed wheat-corn-soybean meal-based diets
PubMed ID: 26898636
Direct demonstration that dietary lysine level controls growth and nitrogen metabolism in pigs â strong evidence for role in protein synthesis/utilization.
- Effects of standardized ileal digestible tryptophan: lysine ratio on growth performance of nursery pigs
PubMed ID: 26440171
AA ratio work in nursery pigs uses lysine as reference â importance for protein accretion in growing animals.
- Compensatory growth response and carcass quality after a period of lysine restriction in lean meat type barrows
PubMed ID: 24444364
Periods of lysine restriction reduced lean gain in pigs, supporting lysineâs role in protein building.
- Utilization of crystalline or protein-bound lysine for growth and carcass traits of barrows and gilts fed individually or in groups
PubMed ID: 23881680
Dose-dependent lysine increased lean deposition and fat-free lean gain in pigs â evidence of lysine supporting protein accretion (animal model).
- Evaluation of standardized ileal digestible lysine requirement of nursery pigs from seven to fourteen kilograms
PubMed ID: 23255816
Pig trials showing improved ADG and G:F with increased lysine indicate enhanced protein synthesis and utilization (animal data).
- Commercially available amino acid supplementation of low-protein diets for broiler chickens with different ratios of digestible glycine+serine:lysine
PubMed ID: 23155025
Commercial amino-acid supplementation (lysine context) enabled reduced crude protein diets in broilers without harming performance â evidence of lysine's key role in protein nutrition (avian model).
- Effects of increasing lysine on carcass composition and cutting yields of immunologically castrated male pigs
PubMed ID: 21383034
Dietary lysine raising lean yield in pigs demonstrates role in protein accretion (animal evidence).
- Evaluation of sex and lysine during the nursery period
PubMed ID: 17296765
Improved ADG and G:F with higher lysine in nursery pigs indicates enhanced protein accretion.
- Estimation of the true ileal digestible lysine and sulfur amino acid requirement and comparison of the bioefficacy of 2-hydroxy-4-(methylthio)butanoic acid and DL-methionine in eleven- to twenty-six-kilogram nursery pigs
PubMed ID: 16775054
Large swine trials demonstrated improved ADG and G:F with increased lysineâsupports protein accretion.
- Nitrogen metabolism and growth performance of gilts fed standard corn-soybean meal diets or low-crude protein, amino acid-supplemented diets
PubMed ID: 12462259
Crystalline lysine in lowâprotein pig diets influenced nitrogen retention and growth under limiting proteinâprotein building relevance.
- The lysine requirement and ratio of total sulfur amino acids to lysine for chicks fed adequate or inadequate lysine
PubMed ID: 9565240
Chick growth/N retention improved with lysineâsupports role in protein accretion (animal evidence).
- The lysine requirement of lactating primiparous sows
PubMed ID: 9581933
Sow trial: higher digestible lysine reduced body protein lossâsupports protein preservation/accumulation in animals.
- The effect of dietary methionine and its relationship to lysine on growth performance of the segregated early-weaned pig
PubMed ID: 8655442
Methionine:lysine ratio study in piglets defined optimal balance for maximal growth (protein accretion).
- Estimation of the standardized ileal digestible lysine requirement for primiparous pregnant sows
PubMed ID: 26174182
Defined optimal dietary SID lysine improved lateâgestation weight gain and colostrum protein in giltsâdirect evidence that lysine supports protein deposition (animal).
- Effects of lysine intake during late gestation and lactation on blood metabolites, hormones, milk composition and reproductive performance in primiparous and multiparous sows
PubMed ID: 18547756
Higher lysine intake in sows increased milk protein/total solids and improved body conditionâstrong animal evidence for proteinâbuilding role.
- Protein bioavailability of Wolffia globosa duckweed, a novel aquatic plant - A randomized controlled trial
PubMed ID: 30591380
Human meal study showed increased plasma essential amino acids, including lysine, after intake â direct evidence of bioavailable amino acids supporting protein synthesis (human).
- Estimation of the standardized ileal digestible valine-to-lysine ratio in 13- to 32-kilogram pigs
PubMed ID: 21057092
Pig feeding trials demonstrate that Val:Lys balance affects growth/protein depositionâsupports lysineâs role in protein building (animal).
- Estimates of the optimum dietary ratio of standardized ileal digestible valine to lysine for eight to twenty-five kilograms of body weight pigs
PubMed ID: 19359510
Animal N-balance/growth data show lysine balance affects nitrogen retention and protein accretion (strong animal evidence).
- Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine
PubMed ID: 19164608
Oneâyear HMB+Arg+Lys increased lean mass and protein turnover (good evidence for proteinâbuilding outcomes; multiâingredient).
- Comparison of Intradialytic Parenteral Nutrition with Glucose or Amino Acid Mixtures in Maintenance Hemodialysis Patients
PubMed ID: 27271658
Intradialytic IV aminoâacid infusion increased albumin (marker of protein accretion) and plasma lysine in hemodialysis patients.
Skin repair (20)
- Lysine clonixinate vs. paracetamol/codeine in postepisiotomy pain
PubMed ID: 9504193
Lysineâclonixinate effective for postâdelivery wound painâapplies directly to wound pain management and recovery.
- [The efficacy of and tolerance for ketoprofen lysine salt in solution for oropharyngeal use in inflammatory lesions of the oral cavity]
PubMed ID: 9265098
Ketoprofenâlysine reduced pain, burning and oedema in oral inflammatory lesionsâdirect benefit to mucosal wound/inflammatory recovery.
- Effect on postoperative analgesia of small-dose lysine acetylsalicylate added to prilocaine during intravenous regional anesthesia
PubMed ID: 9141935
Regional addition of aspirinâlysine prolonged analgesia and reduced opioid need after surgeryâimproves early postoperative recovery.
- [Efficacy and tolerability 80 mg granulated ketoprofen lysine salt in posttraumatic orodental pain: double blind vs placebo study]
PubMed ID: 8741094
Ketoprofenâlysine reduced pain and inflammatory signs after dental surgeryâsupports local healing and recovery.
- Comparative study of ibuprofen lysine and acetaminophen in patients with postoperative dental pain
PubMed ID: 8595637
Ibuprofenâlysine provided faster and greater analgesia after dental surgeryâfacilitates early recovery and comfort.
- Treatment of symptomatic oral mucositis with sodium hyaluronate and synthetic amino acid precursors of collagen in patients undergoing haematopoietic stem cell transplantation
PubMed ID: 29921408
Spray containing Lâlysine among other amino acids + HA significantly reduced oral mucositis severity and duration in HSCT patients (clinical benefit; multiâcomponent product).
- Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
PubMed ID: 15105032
HMB+Arg+Lys increased wholeâbody protein synthesis and improved function in eldersâsupports anabolic capacity and tissue repair (multiâingredient).
- Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery
PubMed ID: 15791100
Tranexamic acid (lysine analogue) markedly reduced intraoperative blood lossârelevant to surgical hemostasis and wound outcomes.
- A comparison of aprotinin and lysine analogues in high-risk cardiac surgery
PubMed ID: 18480196
Large RCT in cardiac surgery showed lysineâanalogue antifibrinolytics impacted bleeding and mortality compared with aprotininâpharmacologic lysine analogues relevant to surgical hemostasis/wound outcomes.
- Effect of lysine hyaluronate on the healing of decubitus ulcers in rehabilitation patients
PubMed ID: 21499725
Randomized double-blind trial: lysine-hyaluronate topical formulation accelerated and increased healing of pressure ulcers across stages.
- A Prospective, Randomized, Multicenter Trial Assessing a Novel Lysine-Derived Urethane Adhesive in a Large Flap Surgical Procedure without Drains
PubMed ID: 26044391
Randomized multicenter trial: lysine-derived adhesive markedly reduced total wound drainage, days of invasive treatment and number of invasive procedures after abdominoplasty.
- Intranasal T-LysYalÂŽ as adjunctive therapy for patients after functional endoscopic sinus surgery
PubMed ID: 27049103
Adjunctive lysineâhyaluronate after sinus surgery improved endoscopic healing and reduced inflammation â direct wound/healing benefit.
- Ancillary therapy of intranasal T-LysYalÂŽ for patients with allergic, non-allergic, and mixed rhinitis
PubMed ID: 27049100
Intranasal lysineâhyaluronate reduced postâtreatment inflammation and symptoms â supports mucosal wound recovery.
- Impact of the Lysine-urethane Adhesive TissuGluÂŽ on Postoperative Complications and Interventions After Drain-free Mastectomy
PubMed ID: 32366427
Lysineâbased surgical glue after mastectomy reduced pain and shortened hospitalization though increased seroma interventionsâdirect surgical wound application evidence.
- Tranexamic acid rapidly inhibits fibrinolysis, yet transiently enhances plasmin generation in vivo
PubMed ID: 33443933
Tranexamic acid rapidly inhibited fibrinolysis in cardiac surgery and altered plasmin generation markers â mechanism directly relevant to bleeding control/wound recovery.
- Effect of age on the efficacy of tranexamic acid: An analysis of heterogeneity of treatment effect within the CRASH-2 dataset
PubMed ID: 34971920
Large reanalysis of CRASHâ2 (TXA = lysine analogue) showed reduced mortality after trauma overall â supports TXA role in hemorrhage control which aids recovery.
- Randomized Single-Center Study of Effectiveness and Safety of a Resorbable Lysine-Based Urethane Adhesive for a Drain-Free Closure of the Abdominal Donor Site in a DIEP Flap Breast Reconstruction Procedure
PubMed ID: 35263551
Lysineâbased adhesive after abdominal flap harvest did not reduce seroma but improved patient satisfactionâsurgical wound care relevance.
- Use of Tranexamic Acid in Liposculpture: A Double-Blind, Multicenter, Randomized Clinical Trial
PubMed ID: 35759637
IV tranexamic acid (lysine analogue) significantly reduced surgical blood lossâstrong, clinically relevant hemostatic effect relevant to wound/surgical recovery.
- Efficacy and tolerance of lysine clonixinate versus paracetamol/codeine following inguinal hernioplasty
PubMed ID: 9638504
Lysineâclonixinate relieved postâhernia pain comparably to paracetamol/codeine with fewer side effectsâbeneficial for surgical recovery.
- Patient-controlled analgesia with morphine plus lysine acetyl salicylate
PubMed ID: 10512278
Reduced opioid use and sedation after major orthopedic surgery suggests improved postoperative recovery support (lysine salt ASA adjunct).
Muscle maintenance (22)
- The Association of the Essential Amino Acids Lysine, Methionine, and Threonine with Clinical Outcomes in Patients at Nutritional Risk: Secondary Analysis of a Randomized Clinical Trial
PubMed ID: 39203745
Lower lysine levels correlated with sarcopenia markers in hospitalized patientsâassociative evidence linking lysine status to muscle loss risk.
- Effect of feeding three lysine to energy diets on growth, body composition and age at puberty in replacement gilts
PubMed ID: 28711219
Higher dietary lysine increased growth rates in gilts â supports role in growth/muscle accretion.
- Effect of a lysine depletion-repletion protocol on the compensatory growth of growing-finishing pigs
PubMed ID: 26812332
Lysine restriction reduced intake/growth and protein deposition; repletion partially restored deposition â direct role in muscle/protein maintenance.
- Dietary lysine requirement for 7-16Â kg pigs fed wheat-corn-soybean meal-based diets
PubMed ID: 26898636
Increasing digestible lysine increased ADG and feed efficiency and reduced PUN in weaned pigs â supports muscle growth/maintenance in animals.
- Effects of standardized ileal digestible tryptophan: lysine ratio on growth performance of nursery pigs
PubMed ID: 26440171
AA ratio studies in nursery pigs implicated lysine as reference AA influencing growth â animal muscle relevance.
- Lysine requirement for growing-finishing immunocastrated male pigs
PubMed ID: 26245916
Higher digestible lysine improved feed efficiency and loin area in immunocastrated pigs â supports muscle development.
- Compensatory growth response and carcass quality after a period of lysine restriction in lean meat type barrows
PubMed ID: 24444364
Lysine-restricted pigs had poorer growth and lean meat but partially caught up with later lysine â shows lysine's role in muscle accrual.
- Evaluation of standardized ileal digestible lysine requirement of nursery pigs from seven to fourteen kilograms
PubMed ID: 23255816
Large pig trials: increasing digestible lysine improved average daily gain and feed efficiency and promoted lean growth (animal-anabolic evidence).
- Effects of porcine somatotropin administration on the responses to dietary lysine and a near-ideal blend of amino acids for growing pigs
PubMed ID: 22896734
Porcine somatotropin plus higher dietary lysine improved lean tissue accretion and growth efficiency â supports role in muscle/protein accretion (animal model).
- Effects of increasing lysine on carcass composition and cutting yields of immunologically castrated male pigs
PubMed ID: 21383034
In pigs, increasing dietary lysine increased lean yield and carcass lean percentage â strong evidence for lysine supporting lean tissue accrual (animal model).
- Effect of diet composition and lysine supply on growth and body composition in juvenile turbot (Psetta maxima)
PubMed ID: 23930712
Fish feeding trial estimated lysine maintenance/efficiency and its effects on body amino-acid composition â relevant to muscle protein turnover (aquatic model).
- Utilization of crystalline or protein-bound lysine for growth and carcass traits of barrows and gilts fed individually or in groups
PubMed ID: 23881680
Raising dietary SID lysine increased ADG and fat-free lean gain in pigs â direct evidence of lysine supporting lean/muscle accretion (animal model).
- The effect of a controlled 8-week metabolic ward based lysine supplementation on muscle function, insulin sensitivity and leucine kinetics in young men
PubMed ID: 22524975
Human RCT: 8 weeks of high lysine intake produced a modest (~7.5%) increase in muscle strengthâdirect evidence for a muscle-related benefit.
- The lysine requirement and ratio of total sulfur amino acids to lysine for chicks fed adequate or inadequate lysine
PubMed ID: 9565240
Poultry growth and feed efficiency improved with dietary lysine (animal muscle growth/maintenance signal).
- Estimation of the true ileal digestible lysine and sulfur amino acid requirement and comparison of the bioefficacy of 2-hydroxy-4-(methylthio)butanoic acid and DL-methionine in eleven- to twenty-six-kilogram nursery pigs
PubMed ID: 16775054
Large nurseryâpig trials demonstrated doseâresponsive growth and feedâefficiency with varying lysineâsupports muscle/lean tissue effects in animals.
- Evaluation of sex and lysine during the nursery period
PubMed ID: 17296765
Large multiâsite nursery pig trial: increased lysine improved ADG and gain:feedâstrong animal evidence for lysine supporting lean growth/muscle deposition.
- Estimation of the standardized ileal digestible valine-to-lysine ratio in 13- to 32-kilogram pigs
PubMed ID: 21057092
Pig feeding trials showing improved ADG and feed efficiency with optimal Val:Lysâsupports lysineâs role in growth/muscle in animals.
- Estimates of the optimum dietary ratio of standardized ileal digestible valine to lysine for eight to twenty-five kilograms of body weight pigs
PubMed ID: 19359510
Pig studies optimizing amino-acid ratios (including lysine) improved growth and N retentionâsupports role in lean tissue accretion (animal data).
- Vitamin D status affects strength gains in older adults supplemented with a combination of β-hydroxy-β-methylbutyrate, arginine, and lysine: a cohort study
PubMed ID: 21807930
Elderly given HMB/arginine/lysine gained fatâfree mass (FFM) â direct evidence of muscle mass benefit (lysine was included in the supplement).
- Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine
PubMed ID: 19164608
Yearâlong HMB+Arg+Lys increased lean tissue mass and protein turnover (randomized trial in elderly).
- Dietary Lysine Requirements of Older Adults Stratified by Age and Sex
PubMed ID: 38735574
Estimated lysine requirements in older adults are higher; meeting needs is important for muscle maintenance with aging.
- Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
PubMed ID: 15105032
Elderly on HMB+Arg+Lys had improved strength and increased protein synthesis (strong human RCT evidence for muscle maintenance within multiâingredient supplement).
Wellbeing (30)
- L-lysine as an adjunct to risperidone in patients with chronic schizophrenia: a double-blind, placebo-controlled, randomized trial
PubMed ID: 25227564
Clinical improvement in schizophrenia symptoms with adjunctive L-lysine suggests broader quality-of-life/overall wellness benefit in that population.
- Effect of an advanced glycation end product-restricted diet and exercise on metabolic parameters in adult overweight men
PubMed ID: 25701333
Low-AGE diet (modified lysine) combined with exercise improved anthropometrics and some lipids in overweight adults.
- A Prospective, Randomized, Multicenter Trial Assessing a Novel Lysine-Derived Urethane Adhesive in a Large Flap Surgical Procedure without Drains
PubMed ID: 26044391
Lysine-based surgical adhesive substantially reduced drainage and procedures after abdominoplasty â meaningful clinical wellness/recovery outcome.
- Comparison of Intradialytic Parenteral Nutrition with Glucose or Amino Acid Mixtures in Maintenance Hemodialysis Patients
PubMed ID: 27271658
Intradialytic IV amino acids increased albumin and improved dialysis adequacy â direct support for clinical nutritional/wellness outcomes.
- Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
PubMed ID: 15105032
Elderly given HMB+arginine+lysine improved mobility, strength and wholeâbody protein synthesis (randomized trial; multiâingredient but clinically relevant outcomes).
- Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine
PubMed ID: 19164608
Oneâyear HMB+Arg+Lys trial in elders increased lean mass and protein turnover (meaningful overall wellness outcomes; multiâingredient).
- Vitamin D status affects strength gains in older adults supplemented with a combination of β-hydroxy-β-methylbutyrate, arginine, and lysine: a cohort study
PubMed ID: 21807930
HMB/arginine/lysine supplement in elderly increased fatâfree mass and, in vitamin Dâreplete subjects, strength â broad wellness and function improvement (lysine part of combo).
- Synbiotic Bacillus megaterium DSM 32963 and n-3 PUFA Salt Composition Elevates Pro-Resolving Lipid Mediator Levels in Healthy Subjects: A Randomized Controlled Study
PubMed ID: 38732601
Synbiotic with lysine salt raised proâresolving mediators and reduced triglycerides â broad wellnessârelevant biochemical effects.
- Combined oral lysine acetylsalicylate and metoclopramide in the acute treatment of migraine: a multicentre double-blind placebo-controlled study
PubMed ID: 7954760
Large RCT: LAS+metoclopramide substantially better than placebo for acute migraineâsignificant improvement in wellâbeing from symptom relief.
- Comparative study of ibuprofen lysine and acetaminophen in patients with postoperative dental pain
PubMed ID: 8595637
Ibuprofenâlysine provided faster and greater dental analgesia than acetaminophen/placeboâmeaningful patient comfort and recovery benefit.
- The effectiveness of combined oral lysine acetylsalicylate and metoclopramide compared with oral sumatriptan for migraine
PubMed ID: 7564725
Large trial: LAS+metoclopramide provided effective migraine relief with better nausea control and fewer adverse effectsâmeaningful overall symptom/wellâbeing benefit (drug combo).
- [Comparative trial of lysine acetylsalicylate and paracetamol on pain in daily medical practice]
PubMed ID: 8958856
Aspirin lysine salt showed modestly better pain control and lower later drug use vs paracetamolâsome advantage for comfort/recovery.
- Effect on postoperative analgesia of small-dose lysine acetylsalicylate added to prilocaine during intravenous regional anesthesia
PubMed ID: 9141935
Adding small aspirinâlysine to regional anesthesia prolonged analgesia and reduced opioid needâclear perioperative wellness benefit.
- Patient-controlled analgesia with morphine plus lysine acetyl salicylate
PubMed ID: 10512278
Lysineâacetylsalicylate added to morphine PCA reduced opioid use and sedation after orthopedic surgery (clinically meaningful).
- Lysine-acetylsalicylic acid in acute migraine attacks
PubMed ID: 10023111
IV lysineâacetylsalicylate relieved migraine faster and with fewer side effects vs ergotamine (improved patient experience).
- Efficacy and safety of intravenous acetylsalicylic acid lysinate compared to subcutaneous sumatriptan and parenteral placebo in the acute treatment of migraine. A double-blind, double-dummy, randomized, multicenter, parallel group study. The ASASUMAMIG Study Group
PubMed ID: 10448545
Large RCT: IV lysineâacetylsalicylate significantly reduced migraine pain vs placebo with favorable tolerability.
- [Efficacy of and tolerance to topical ketoprofen lysinate solution in acute inflammation of the mouth in orthodontic therapy. Randomized single blind study, with parallel groups, versus benzidamine hydrochloride]
PubMed ID: 11345687
Ketoprofenâlysinate mouth solution relieved orthodontic pain better than benzidamine (improved oral comfort).
- Efficacy and safety of ketoprofen lysine salt mouthwash versus benzydamine hydrochloride mouthwash in acute pharyngeal inflammation: a randomized, single-blind study
PubMed ID: 11589263
Ketoprofenâlysine mouthwash gave longer analgesia and better tolerability vs benzydamine for sore throat.
- The Preventive Effect of L-Lysine on Lysozyme Glycation in Type 2 Diabetes
PubMed ID: 26853287
Lâlysine supplementation in T2DM lowered AGEs and improved lysozyme function â broad health/wellness implications.
- Oral lysine clonixinate in the acute treatment of migraine: a double-blind placebo-controlled study
PubMed ID: 11299430
Lysineâclonixinate relieved moderate migraine attacks more than placebo and reduced rescue medication need.
- [Otorhinolaryngologic pain in the adult. A comparison of the analgesic efficacy of lysine acetylsalicylate and paracetamol]
PubMed ID: 11413842
Lysine salt of aspirin relieved ENT pain better than paracetamol (improved symptom relief).
- The effectiveness of quality protein maize in improving the nutritional status of young children in the Ethiopian highlands
PubMed ID: 20973462
Improved child weight trajectories with higher-lysine staple (QPM) supports broader wellness in growth period.
- Impact of lysine-fortified wheat flour on morbidity and immunologic variables among members of rural families in northwest Syria
PubMed ID: 18947029
Community trial showing reduced diarrheal disease reflects a meaningful population health/wellness benefit from lysine fortification.
- Lysine-fortified wheat flour improves the nutritional and immunological status of wheat-eating families in northern China
PubMed ID: 15214257
Threeâmonth lysine fortification improved child growth and adult nutritional markersâbroad overall wellness gains.
- Lysine fortification of wheat flour improves selected indices of the nutritional status of predominantly cereal-eating families in Pakistan
PubMed ID: 15214256
Large doubleâblind fortification improved growth, hemoglobin, transferrin and prealbuminâclear overall nutritional benefit.
- Effect of lysine supplementation on health and morbidity in subjects belonging to poor peri-urban households in Accra, Ghana
PubMed ID: 20720257
Fewer total days ill and lower respiratory morbidity in supplemented groups indicate overall health/wellness benefit.
- Effect of lysine hyaluronate on the healing of decubitus ulcers in rehabilitation patients
PubMed ID: 21499725
Topical lysine-hyaluronate accelerated pressure-ulcer healing, improving clinical outcomes relevant to patient wellness.
- Effects of the Lysulin⢠supplementation on pre-diabetes: A randomized double-blind, placebo-controlled clinical trial
PubMed ID: 32795739
Lysulin⢠trial improved glycaemic control and reduced diabetes progressionâbroadly relevant to overall metabolic wellness (combination product).
- Efficacy of Ibuprofen Lysine on First-Trimester AbortionRelated Pain and Hemorrhage: A Randomized TripleBlinded Clinical Trial
PubMed ID: 38301081
Ibuprofenâlysine reduced pain and bleeding in medical abortionâimmediate clinical wellness benefit from a lysine salt formulation (pharmaceutical context).
- The Association of the Essential Amino Acids Lysine, Methionine, and Threonine with Clinical Outcomes in Patients at Nutritional Risk: Secondary Analysis of a Randomized Clinical Trial
PubMed ID: 39203745
In malnourished inpatients, lysine levels correlated with markers of malnutrition and sarcopenia and associated with outcomesâlinks lysine status to clinical wellness.
Metabolism (23)
- Physical activity and markers of glycation in older individuals: data from a combined cross-sectional and randomized controlled trial (EXAMIN AGE)
PubMed ID: 32356559
Study measured proteinâbound CML (a lysine AGE) and reported differences by activity status; links lysine glycation to metabolic/ageing markers.
- Effects of supplemental chromium propionate and rumen-protected amino acids on nutrient metabolism, neutrophil activation, and adipocyte size in dairy cows during peak lactation
PubMed ID: 24731640
Rumenâprotected lysine increased insulin in lactating cows, indicating metabolic signaling effects (animal model).
- A novel nutritional supplement containing amino acids and chromium decreases postprandial glucose response in a randomized, double-blind, placebo-controlled study
PubMed ID: 32579549
MultiâAA drink (includes lysine) lowered postprandial glucose in overweight adults; benefit cannot be attributed to lysine alone.
- Suppression of native defense mechanisms, SIRT1 and PPARÎł, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic diseases
PubMed ID: 23636469
Dietary AGE restriction decreased circulating AGEs and increased SIRT1/PPARÎł â metabolic regulators, though study concerns AGEs not lysine supplementation.
- Utilization of crystalline or protein-bound lysine for growth and carcass traits of barrows and gilts fed individually or in groups
PubMed ID: 23881680
Dose-dependent lysine increased lean deposition and growth in pigs â demonstrates metabolic/anabolic role of lysine (animal model).
- Effect of an advanced glycation end product-restricted diet and exercise on metabolic parameters in adult overweight men
PubMed ID: 25701333
Low-AGE diet (modified lysine species) plus exercise improved body fat indices and lipid measures in overweight men.
- Dietary lysine requirement for 7-16Â kg pigs fed wheat-corn-soybean meal-based diets
PubMed ID: 26898636
Raising digestible lysine in pig diets improved ADG and feed efficiency â metabolic (nutrient utilization) effect in animals.
- The Preventive Effect of L-Lysine on Lysozyme Glycation in Type 2 Diabetes
PubMed ID: 26853287
Lâlysine supplementation lowered AGEs in T2DM â metabolic biomarker improvement relevant to metabolism.
- Precision feeding can significantly reduce lysine intake and nitrogen excretion without compromising the performance of growing pigs
PubMed ID: 26759074
Precision lysine feeding in pigs cut lysine intake and nitrogen waste while maintaining growth â improved nitrogen/metabolic efficiency.
- Effects of the Lysulin⢠supplementation on pre-diabetes: A randomized double-blind, placebo-controlled clinical trial
PubMed ID: 32795739
Randomized trial of a product containing lysine (Lysulinâ˘) improved glycaemic measures and reduced progression to diabetes (combination product, attribution to lysine uncertain).
- The consumption of animal products is associated with plasma levels of alpha-aminoadipic acid (2-AAA)
PubMed ID: 38658223
Studies link the lysineâcatabolite 2âAAA to cardiometabolic risk and show diet/lysine intake influences 2âAAAâdirectly relevant to lysine metabolism and metabolic risk.
- Metabolic plasticity of the gut microbiome in response to diets differing in glycemic load in a randomized, crossover, controlled feeding study
PubMed ID: 40619005
Direct enrichment of microbial Lâlysine biosynthesis pathway on the lowâglycemic dietâclear metabolic signal.
- Evaluation of the antiobesity effects of an amino acid mixture and conjugated linoleic acid on exercising healthy overweight humans: a randomized, double-blind, placebo-controlled trial
PubMed ID: 20819421
A small lysineâcontaining amino acid mix with exercise reduced waist/hip measures (metabolic/bodyâcomposition effect), though multiâingredient.
- Effects of Histidine Supplementation on Global Serum and Urine (1)H NMR-based Metabolomics and Serum Amino Acid Profiles in Obese Women from a Randomized Controlled Study
PubMed ID: 28447460
Histidine supplementation raised lysine and associated with improved lipid/glucose metabolomic markers â lysine change was secondary but metabolism improved.
- Are dietary amino acids prospectively predicts changes in serum lipid profile?
PubMed ID: 31235103
Large cohort: higher dietary lysine intake prospectively associated with increased triglycerides and total cholesterol (strong observational metabolic signal).
- [Changes in levels of human nutritious metabolites after exposure to abnormal acceleration of sea state]
PubMed ID: 27514255
Acute simulated-motion stress produced a marked (~28%) drop in serum L-lysine and correlated metabolic/hormonal changes â direct metabolic signal.
- Intracellular amino acid concentrations in children with chronic renal insufficiency
PubMed ID: 8611355
Children with chronic renal failure had lower intracellular lysineârelevant to metabolic aminoâacid handling (observational).
- Altering dietary lysine:arginine ratio has little effect on cardiovascular risk factors and vascular reactivity in moderately hypercholesterolemic adults
PubMed ID: 20042191
Dietary Lys:Arg ratio manipulation altered postprandial triglycerides and hsCRP (dietary metabolic effects).
- Effects of metformin and pioglitazone on serum pentosidine levels in type 2 diabetes mellitus
PubMed ID: 21472665
Metformin/pioglitazone RCT improved HbA1c and lowered pentosidine â direct metabolic (glycemic) improvements; relates to lysine-derived AGEs.
- l-Carnosine supplementation attenuated fasting glucose, triglycerides, advanced glycation end products, and tumor necrosis factor-Îą levels in patients with type 2 diabetes: a double-blind placebo-controlled randomized clinical trial
PubMed ID: 29420997
l-Carnosine improved fasting glucose, triglycerides and AGEs in T2D â clear metabolic benefits though not lysine per se.
- The Effects of Taurine Supplementation on Metabolic Profiles, Pentosidine, Soluble Receptor of Advanced Glycation End Products and Methylglyoxal in Adults With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 32861603
Taurine supplementation improved glycemia, lipids and reduced AGEs in T2D â strong metabolic effects (indirect link to lysine/AGE metabolism).
- Estimates of the optimum dietary ratio of standardized ileal digestible valine to lysine for eight to twenty-five kilograms of body weight pigs
PubMed ID: 19359510
Pig N-balance/growth studies manipulating valine:lysine ratios showed clear effects on growth/N retentionârelevant to lysineâs metabolic role (animal model).
- Estimation of the standardized ileal digestible valine-to-lysine ratio in 13- to 32-kilogram pigs
PubMed ID: 21057092
Pig feeding trials demonstrating optimal Val:Lys for growth/feed efficiencyâsupports lysineâs central metabolic role in protein accretion (animal data).
Immune support (14)
- Ancillary therapy of intranasal T-LysYalÂŽ for patients with allergic, non-allergic, and mixed rhinitis
PubMed ID: 27049100
Intranasal lysineâhyaluronate reduced nasal inflammation in rhinitis patients â immunomodulatory clinical signal.
- The Preventive Effect of L-Lysine on Lysozyme Glycation in Type 2 Diabetes
PubMed ID: 26853287
3 g/day Lâlysine in T2DM reduced AGEs and restored lysozyme bactericidal activity â direct human immune benefit.
- Effects of dietary supplementation with lysine-yielding Bacillus subtilis on gut morphology, cecal microflora, and intestinal immune response of Linwu ducks
PubMed ID: 26440014
Lysineâproducing Bacillus in ducks improved mucosal cytokines and beneficial bacteria â animal immune/mucosal effects.
- Suppression of native defense mechanisms, SIRT1 and PPARÎł, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic diseases
PubMed ID: 23636469
Low-AGE diet raised SIRT1/PPARÎł (anti-inflammatory regulators) â indirect immunomodulatory signal (not lysine supplement).
- Effect of lysine supplementation on health and morbidity in subjects belonging to poor peri-urban households in Accra, Ghana
PubMed ID: 20720257
Randomized trial: 1 g/day lysine reduced childhood diarrheal episodes and adult respiratory morbidity â direct immune/illness benefit.
- The effectiveness of quality protein maize in improving the nutritional status of young children in the Ethiopian highlands
PubMed ID: 20973462
Quality-protein maize (higher lysine) improved child weight outcomes, which can support immune resilience (indirect nutritional effect).
- Impact of lysine-fortified wheat flour on morbidity and immunologic variables among members of rural families in northwest Syria
PubMed ID: 18947029
Randomized trial: lysineâfortified wheat reduced diarrheal episodes in women and increased complement C3 in menâdirect immune/clinical benefit.
- Lysine fortification of wheat flour improves selected indices of the nutritional status of predominantly cereal-eating families in Pakistan
PubMed ID: 15214256
Doubleâblind fortification trial increased CD4/CD8 and C3 and improved nutritional markersâsupports immune benefit.
- Lysine-fortified wheat flour improves the nutritional and immunological status of wheat-eating families in northern China
PubMed ID: 15214257
Community lysine fortification raised CD3 and several immunoglobulinsâdirect immune improvements in humans.
- Effects of supplemental chromium propionate and rumen-protected amino acids on nutrient metabolism, neutrophil activation, and adipocyte size in dairy cows during peak lactation
PubMed ID: 24731640
Rumenâprotected lysine+methionine altered neutrophil inflammatory transcripts in cows, indicating immunomodulatory effects (animal model).
- Synbiotic Bacillus megaterium DSM 32963 and n-3 PUFA Salt Composition Elevates Pro-Resolving Lipid Mediator Levels in Healthy Subjects: A Randomized Controlled Study
PubMed ID: 38732601
nâ3 PUFA Lâlysine salt raised proâresolving lipid mediator precursors (antiâinflammatory/immune resolution).
- Influence of pre-press solvent-extracted cottonseed meal supplemented with exogenous enzyme and digestible lysine on performance, digestibility, carcass and immunity responses of broiler chickens
PubMed ID: 19320937
Digestible lysine increased antibody titres in broiler chickens (direct immune effect but nonâhuman).
- A multipeptide vaccine plus toll-like receptor agonists LPS or polyICLC in combination with incomplete Freund's adjuvant in melanoma patients
PubMed ID: 31248461
PolyâICLC used as an adjuvant (polyâLâlysine component); study showed stronger/durable CD8 Tâcell responses with adjuvants â directly relevant to immune potentiation.
- Targeting intracellular signaling as an antiviral strategy: aerosolized LASAG for the treatment of influenza in hospitalized patients
PubMed ID: 29511170
Inhaled acetylsalicylateâlysine (LASAG) shortened influenza symptom/sign resolutionâclinical antiviral/illness benefit though lysine is a drug counterion.
Tissue repair (14)
- Effects of amino acids enriched tears substitutes on the cornea of patients with dysfunctional tear syndrome
PubMed ID: 23617248
Amino-acid enriched eye drops accelerated ocular-surface recovery vs controlâsupports mucosal/tissue repair benefits of an AA-containing formulation.
- Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
PubMed ID: 15105032
Increased wholeâbody protein synthesis and improved mobility in elderly with HMB+Arg+Lys suggests enhanced capacity for tissue repair (multiâingredient evidence).
- Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine
PubMed ID: 19164608
Yearâlong increases in protein turnover and lean mass with HMB/Arg/Lys imply improved substrate availability for repair.
- Treatment of symptomatic oral mucositis with sodium hyaluronate and synthetic amino acid precursors of collagen in patients undergoing haematopoietic stem cell transplantation
PubMed ID: 29921408
Aminoâacid + hyaluronate spray containing Lâlysine reduced oral mucositis severity/duration after HSCTâclinical tissue repair benefit (multicomponent).
- [The efficacy of and tolerance for ketoprofen lysine salt in solution for oropharyngeal use in inflammatory lesions of the oral cavity]
PubMed ID: 9265098
Ketoprofenâlysine reduced burning, pain and oedema in oral lesionsâsupports tissue healing in oropharyngeal inflammation.
- Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery
PubMed ID: 15791100
Tranexamic acid (lysine analogue) substantially reduced surgical blood lossâuseful in surgical tissue repair contexts (haemostatic effect).
- A comparison of aprotinin and lysine analogues in high-risk cardiac surgery
PubMed ID: 18480196
Lysineâanalogue antifibrinolytics influenced surgical bleeding and outcomesârelevant to perioperative tissue/hemostatic repair.
- Effect of lysine hyaluronate on the healing of decubitus ulcers in rehabilitation patients
PubMed ID: 21499725
Topical lysine-hyaluronate substantially improved healing rates across pressure-ulcer stages â direct tissue-repair benefit.
- A Prospective, Randomized, Multicenter Trial Assessing a Novel Lysine-Derived Urethane Adhesive in a Large Flap Surgical Procedure without Drains
PubMed ID: 26044391
Lysine-based surgical adhesive markedly reduced drain volumes and invasive treatments â strong clinical evidence for improved tissue repair management post-op.
- Effects of dietary supplementation with lysine-yielding Bacillus subtilis on gut morphology, cecal microflora, and intestinal immune response of Linwu ducks
PubMed ID: 26440014
Improved intestinal villus morphology with lysineâproducing Bacillus in ducks â animal tissue integrity/repair signal.
- Intranasal T-LysYalÂŽ as adjunctive therapy for patients after functional endoscopic sinus surgery
PubMed ID: 27049103
Clinical improvement in healing and lowered inflammatory cells after FESS with lysineâhyaluronate â direct tissue repair benefit.
- Ancillary therapy of intranasal T-LysYalÂŽ for patients with allergic, non-allergic, and mixed rhinitis
PubMed ID: 27049100
Adjunct intranasal lysineâhyaluronate reduced rhinitis inflammation and improved endoscopy â supports mucosal tissue repair.
- Impact of the Lysine-urethane Adhesive TissuGluÂŽ on Postoperative Complications and Interventions After Drain-free Mastectomy
PubMed ID: 32366427
Use of a lysineâurethane adhesive in surgery directly addresses tissue closure/repair outcomes (reduced pain/shorter stay but increased seroma).
- Tranexamic acid rapidly inhibits fibrinolysis, yet transiently enhances plasmin generation in vivo
PubMed ID: 33443933
TXA's potent fibrinolysis blockade and effects on plasmin generation are mechanistically important for stabilizing clots and enabling tissue repair.
Digestive support (11)
- Plasma amino acid concentrations in term-born infants fed a whey predominant or a whey hydrolysate formula
PubMed ID: 9002081
Infants fed whey hydrolysate had higher plasma lysineâshows dietary lysine availability/absorption differences (human trial).
- Milk Protein Glycation Compromises Postprandial Lysine Bioavailability but does not Modulate Postprandial Muscle Protein Synthesis Rates In Vivo in Males: A Double-blind, Randomized Parallel Trial
PubMed ID: 40441386
Randomized trial showing glycation of milk protein lowers postâmeal plasma lysine substantiallyâdirect relevance to digestive/bioavailability.
- Oral Helicobacter pylori, its relationship to successful eradication of gastric H. pylori and saliva culture confirmation
PubMed ID: 25179088
Lysineâcontaining mouthwash markedly reduced oral H. pylori and improved gastric eradicationâdirect digestive/infectious benefit.},{
- Efficacy of a mouthwash containing Îľ-poly-L-lysine, funme peptides and domiphen in reducing halitosis and supragingival plaque: a randomized clinical trial
PubMed ID: 38702623
Mouthwash containing ÎľâpolyâLâlysine significantly reduced volatile sulfur compounds and plaque â directly improves oral (digestive tract entry) health.
- Prediction of apparent, standardized, and true ileal digestible total and reactive lysine contents in heat-damaged soybean meal samples
PubMed ID: 23365308
Heatâdamaged soybean meal markedly reduced lysine content and ileal digestibility in pigs (feed quality effect).
- Circulatory amino acid responses to milk consumption in dairy and lactose intolerant individuals
PubMed ID: 35459911
Postprandial plasma AA measures after different milks showing little change in lysine appearance in most groupsânutrient absorption context.
- Effects of ibuprofen lysinate and acetylsalicylic acid on gastric and duodenal mucosa. Randomized single-blind placebo-controlled endoscopic study in healthy volunteers
PubMed ID: 7945519
Randomized endoscopic study: ibuprofenâlysinate caused much less duodenal erosion than aspirinâdirectly relevant to mucosal/gastric safety (digestive support).
- Impact of lysine-fortified wheat flour on morbidity and immunologic variables among members of rural families in northwest Syria
PubMed ID: 18947029
Lysineâfortified wheat significantly reduced diarrheal episodes and days ill in womenâdirect digestive/enteric benefit.
- The effectiveness of quality protein maize in improving the nutritional status of young children in the Ethiopian highlands
PubMed ID: 20973462
Feeding higher-lysine quality-protein maize helped prevent weight faltering in young children, consistent with improved nutritional/digestive outcomes.
- Effect of lysine supplementation on health and morbidity in subjects belonging to poor peri-urban households in Accra, Ghana
PubMed ID: 20720257
Randomized lysine supplementation substantially lowered diarrheal episodes and days ill in children â direct digestive morbidity benefit.
- Effects of dietary supplementation with lysine-yielding Bacillus subtilis on gut morphology, cecal microflora, and intestinal immune response of Linwu ducks
PubMed ID: 26440014
Lysineâproducing Bacillus improved jejunal/ileal villus height, microbiota composition and mucosal cytokines in ducklings â strong gut morphology/microbiota signal.
Nutrient uptake (10)
- Protein bioavailability of Wolffia globosa duckweed, a novel aquatic plant - A randomized controlled trial
PubMed ID: 30591380
Human meal study directly demonstrated increased plasma essential amino acids (including lysine) after ingestion, showing dietary absorption and transport (human PK evidence).
- Predicting rapid analgesic onset of ibuprofen salts compared with ibuprofen acid: T(lag), T(low), T(med), and a novel parameter, T(C)(maxRef)
PubMed ID: 29667449
Pharmacokinetic study showing ibuprofenâlysine (lysine as counterion) has much faster absorptionâdemonstrates lysine/formulation effects on absorption/transport (pharmaceutical context).
- Precision feeding can significantly reduce lysine intake and nitrogen excretion without compromising the performance of growing pigs
PubMed ID: 26759074
Precision individual lysine feeding reduced digestible lysine intake and nitrogen excretion by ~26â30% with maintained growth â improved nutrient use/transport efficiency in animals.
- Effects of co-administration of ibuprofen-lysine on the pharmacokinetics of amikacin in preterm infants during the first days of life
PubMed ID: 15249757
Ibuprofenâlysine coâadministration prolonged amikacin halfâlifeâdemonstrates that lysineâcontaining salts can alter drug pharmacokinetics (transport/clearance).
- Lysine fortification of wheat flour improves selected indices of the nutritional status of predominantly cereal-eating families in Pakistan
PubMed ID: 15214256
Fortification increased transferrin and prealbuminâmarkers of nutrient transport and protein status.
- Zinc concentration in tissues and performance of weanling pigs fed pharmacological levels of zinc from ZnO, Zn-methionine, Zn-lysine, or ZnSO4
PubMed ID: 8818803
High dietary Zn as Znâlysine raised tissue and serum zincâdirect evidence that lysine complexes alter mineral transport/bioavailability.
- Influence of dietary lysine on the utilization of zinc from zinc sulfate and a zinc-lysine complex by young pigs
PubMed ID: 9581930
Zincâlysine complex and dietary lysine altered tissue zinc measures in pigs, indicating aminoâacidâmineral transport/interactions (animal study).
- Bioavailability of free lysine and protein-bound lysine from casein and fishmeal in juvenile turbot (Psetta maxima)
PubMed ID: 25683818
Crystalline Lâlysine showed full bioavailability vs protein sources in juvenile turbotâevidence for free lysine transport/availability (aquaculture).
- Prediction of apparent, standardized, and true ileal digestible total and reactive lysine contents in heat-damaged soybean meal samples
PubMed ID: 23365308
Heat damage to soybean meal reduced reactive and digestible lysine in pigsâfeed matrix effect on lysine availability (animal).
- Comparison of Intradialytic Parenteral Nutrition with Glucose or Amino Acid Mixtures in Maintenance Hemodialysis Patients
PubMed ID: 27271658
Intradialytic glucose infusion raised plasma lysine; IV aminoâacid infusion increased albumin and plasma AAs â direct manipulation of systemic lysine availability.
Healthy aging (7)
- Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
PubMed ID: 15105032
HMB+Arg+Lys improved mobility/strength and protein synthesis in elderly (supports functional aspects of healthy aging).
- Prebiotic supplementation modulates advanced glycation end-products (AGEs), soluble receptor for AGEs (sRAGE), and cardiometabolic risk factors through improving metabolic endotoxemia: a randomized-controlled clinical trial
PubMed ID: 31728681
Resistant dextrin lowered CML (a lysineâderived AGE) and improved sRAGE/oxidative stress markersârelevant to ageing/AGE burden.},{
- The Preventive Effect of L-Lysine on Lysozyme Glycation in Type 2 Diabetes
PubMed ID: 26853287
Lâlysine supplementation reduced AGEs in T2DM patients â potentially protective against AGEârelated aging processes.
- Dietary Lysine Requirements of Older Adults Stratified by Age and Sex
PubMed ID: 38735574
IAAO requirement study in older adults directly informs lysine needs in aging and has clear implications for maintaining protein status with age.
- Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes
PubMed ID: 27609106
Higher lysineâderived AGE levels associated with renal structural lesions and faster renal decline in T2DM â aging/longâterm organ damage association.
- Suppression of native defense mechanisms, SIRT1 and PPARÎł, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic diseases
PubMed ID: 23636469
Reducing dietary AGEs (including CML) increased SIRT1 and PPARÎł â pathways relevant to healthy aging (indirect to lysine supplementation).
- Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine
PubMed ID: 19164608
Yearâlong HMB/Arg/Lys increased lean mass and protein turnover in older adults (clinically relevant to aging).
Skin health (6)
- Microneedling-assisted topical tranexamic acid solution versus 4% hydroquinone for treating melasma: A split-face randomized study
PubMed ID: 34525492
Topical tranexamic acid with microneedling reduced melasma severity comparable to hydroquinone â TXA is a lysine derivative used topically for pigment/skin benefits.
- Ancillary therapy of intranasal T-LysYalÂŽ for patients with allergic, non-allergic, and mixed rhinitis
PubMed ID: 27049100
Intranasal lysineâhyaluronate reduced rhinitis signs and inflammatory cytology â supports mucosal/skin barrier healing.
- Intranasal T-LysYalÂŽ as adjunctive therapy for patients after functional endoscopic sinus surgery
PubMed ID: 27049103
Lysineâhyaluronate nasal spray improved mucosal healing and reduced inflammation after FESS â translates to tissue/mucosal health.
- A Prospective, Randomized, Multicenter Trial Assessing a Novel Lysine-Derived Urethane Adhesive in a Large Flap Surgical Procedure without Drains
PubMed ID: 26044391
Lysine-based surgical adhesive reduced drainage and invasive treatments after abdominoplasty â directly relevant to post-surgical skin healing outcomes.
- Effect of lysine hyaluronate on the healing of decubitus ulcers in rehabilitation patients
PubMed ID: 21499725
Topical lysine-hyaluronate significantly accelerated healing and reduced ulcer size versus standard hyaluronate â direct skin/dermal benefit.
- Effect of a New Hyaluronic Acid Hydrogel Dermal Filler Cross-Linked With Lysine Amino Acid for Skin Augmentation and Rejuvenation
PubMed ID: 37265096
Lysineâcrosslinked HA filler increased collagen/skin thickness and showed superior 12âmonth retention versus comparator (clinical device evidence).
Mood balance (4)
- Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans
PubMed ID: 17510493
Randomized human trial: oral Lâlysine+Lâarginine lowered anxiety scores and basal salivary cortisol (clinically meaningful though combination product).
- L-lysine as an adjunct to risperidone in patients with chronic schizophrenia: a double-blind, placebo-controlled, randomized trial
PubMed ID: 25227564
Randomized controlled trial: adjunctive 6 g/day L-lysine improved negative and general psychopathology in chronic schizophrenia (direct clinical evidence).
- Baseline serum amino acid levels predict treatment response to augmentation with N-acetylcysteine (NAC) in a bipolar disorder randomised trial
PubMed ID: 34438354
Lower baseline serum lysine predicted better antidepressant response in bipolar patientsâlink between lysine levels and mood outcomes.
- First-in-Human Randomized Trial to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the KDM1A Inhibitor Vafidemstat
PubMed ID: 33755924
Vafidemstat (KDM1A inhibitor) showed CNS penetration and target engagement; KDM1A acts on lysine demethylation and the compound is being investigated for neuro/psychiatric indications (relevant to mood).
Joints & tendons (4)
- Effect of a New Hyaluronic Acid Hydrogel Dermal Filler Cross-Linked With Lysine Amino Acid for Skin Augmentation and Rejuvenation
PubMed ID: 37265096
Lysineâcrosslinked HA filler increased collagen/skin thickness and retentionâdevice evidence of collagen stimulation via lysineâchemistry crosslinking.
- Effect of lysine hyaluronate on the healing of decubitus ulcers in rehabilitation patients
PubMed ID: 21499725
Topical lysine-hyaluronate accelerated ulcer healing â consistent with improved extracellular matrix/collagen-mediated repair (clinical topical evidence).
- Intranasal T-LysYalÂŽ as adjunctive therapy for patients after functional endoscopic sinus surgery
PubMed ID: 27049103
Lysineâhyaluronate formulation improved mucosal healing after sinus surgery â plausible link to extracellular matrix/remodeling (collagen/hyaluronan) in wound repair.
- Ancillary therapy of intranasal T-LysYalÂŽ for patients with allergic, non-allergic, and mixed rhinitis
PubMed ID: 27049100
Intranasal lysineâhyaluronate reduced inflammation and improved endoscopic findings â supports tissue matrix repair processes.
Energy & Fatigue (2)
- Evaluation of sex and lysine during the nursery period
PubMed ID: 17296765
Higher dietary lysine increased ADG and feed efficiency in nursery pigsâtranslates to improved growth energy utilization in animals.
- Patient-controlled analgesia with morphine plus lysine acetyl salicylate
PubMed ID: 10512278
Lysineâacetylsalicylate group had less morphineârelated sedation postoperatively (better alertness/energy).
Hair & Nails (2)
- Efficacy and safety of fosravuconazole L-lysine ethanolate, a novel oral triazole antifungal agent, for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study
PubMed ID: 30156314
Fosravuconazole Lâlysine ethanolate gave substantially higher clinical/mycological cure rates for onychomycosisâdirect and strong nailâhealth outcome (drug uses Lâlysine salt).
- Effects of additional oral fosravuconazole l-lysine ethanolate therapy following inadequate response to initial treatment for onychomycosis: A multicenter, randomized controlled trial
PubMed ID: 38482989
Fosravuconazole formulated as Lâlysine ethanolate produced clinically meaningful increases in complete cure for onychomycosis (nail health) â direct formulation link to lysine.
Exercise recovery (1)
- Association of skeletal muscle and serum metabolites with maximum power output gains in response to continuous endurance or high-intensity interval training programs: The TIMES study - A randomized controlled trial
PubMed ID: 30742692
Baseline lysine correlated with power gains following HIIT â an association between lysine levels and training responsiveness (indirect to recovery/adaptation).
Bone health (1)
- [The effects of the carbocalcitonin + arginine-lysine-lactose combination in senile involutional osteoporosis]
PubMed ID: 8028755
Arginineâlysineâlactose adjunct to calcitonin improved BMD and lowered boneâresorption markers in elderly patients â direct bone outcome with lysine present.
Forms of Lysine
The 2 forms a label may print instead of Lysine. Each is a different substance with its own identifier, and none of them has research of its own â the studies are the ones on this page.
Similar by evidence
Supplements the same benefits carry qualifying findings for â a fact about the evidence graph, not a recommendation to swap.
Products with Lysine
Search all1614 products whose verified label declares Lysine â not every bottle that mentions it in a title.