ATP
11 benefits mapped to clinical evidence across supplements.
Dose per serving from research
9 study groups in 9 studies say how much ATP participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 44% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 50 mg to 100 mg | 2 |
| 100 mg to 250 mg | 3 |
| 250 mg to 500 mg | 4 |
Benefit Evidence
Research sources
Blood circulation (26)
- Improvement in cardiac energetics by perhexiline in heart failure due to dilated cardiomyopathy
PubMed ID: 25650370
Perhexiline improved myocardial PCr/ATP ratio and symptoms, implying enhanced cardiac energetic function and circulation.
- Effects of nicorandil on cardiac sympathetic nerve activity after reperfusion therapy in patients with first anterior acute myocardial infarction
PubMed ID: 15791442
Post‑reperfusion nicorandil improved MIBG and washout rates and remodelling—supports improved myocardial circulation.
- Nicorandil versus isosorbide dinitrate as adjunctive treatment to direct balloon angioplasty in acute myocardial infarction
PubMed ID: 14729792
Nicorandil markedly improved ST recovery and microcirculatory flow—direct evidence of improved cardiac/microcirculation.
- Comparative effects of nicorandil with isosorbide mononitrate on cardiac sympathetic nerve activity and left ventricular function in patients with ischemic cardiomyopathy
PubMed ID: 16169327
Nicorandil (KATP opener) produced clear improvements in LVEF, reduced LVEDV and improved sympathetic imaging markers — strong evidence for improved cardiac circulation.
- Influence of levosimendan on organ dysfunction in patients with severely reduced left ventricular function undergoing cardiac surgery
PubMed ID: 24781725
Levosimendan (a calcium sensitizer and KATP channel modulator) reduced vasopressor need and some adverse events — supports improved hemodynamic/ circulatory stability in low-LVEF perioperative patients.
- Improved preservation of saphenous vein grafts by the use of glyceryl trinitrate-verapamil solution during harvesting
PubMed ID: 7586430
Graft treatment preserved endothelium and nearly doubled tissue ATP—directly relevant to vascular health and local circulation in graft tissue.
- Preconditioning improves myocardial preservation in patients undergoing open heart operations
PubMed ID: 9386697
Ischemic preconditioning preserved myocardial ATP and improved contractile recovery and enzyme leakage — indicates better myocardial perfusion/function after ischemia.
- Comparison of adenosine triphosphate and dipyridamole in diagnosis by thallium-201 myocardial scintigraphy
PubMed ID: 9098205
IV ATP produced larger coronary flow reserve than dipyridamole—direct evidence of improved coronary circulation.
- Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction
PubMed ID: 10080465
Nicorandil (KATP channel opener) significantly reduced angiographic no-reflow and improved microvascular perfusion after MI—strong evidence for circulation improvement via KATP pathways.
- Dose-dependent prophylactic effect of nicorandil, an ATP-sensitive potassium channel opener, on intra-operative myocardial ischaemia in patients undergoing major abdominal surgery
PubMed ID: 11573520
Large clinical trial found high‑dose nicorandil (KATP opener) markedly reduced intra‑operative myocardial ischemia, a strong marker of improved myocardial perfusion.
- Effect of intracoronary nicorandil administration on preventing no-reflow/slow flow phenomenon during rotational atherectomy
PubMed ID: 12499617
Intracoronary nicorandil greatly reduced no‑reflow incidence during atherectomy (improved microvascular perfusion) — clinical human evidence tied to KATP channel activation.
- Opening of K(ATP) channel attenuates the increase in QT dispersion produced by the first balloon inflation during coronary angioplasty
PubMed ID: 12030342
IV nicorandil before angioplasty reduced ischemic markers and arrhythmia, implying improved myocardial perfusion during ischemia.
- Myocardial metabolic changes during pediatric cardiac surgery: a randomized study of 3 cardioplegic techniques
PubMed ID: 15224023
Warm blood cardioplegia reduced myocardial ATP loss and improved metabolic recovery in cyanotic children, indicating improved myocardial perfusion/recovery.
- Nicorandil improves cardiac function and clinical outcome in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: role of inhibitory effect on reactive oxygen species formation
PubMed ID: 15459610
Nicorandil (a K(ATP) opener) given before PCI suppressed oxidative stress, reduced no-reflow and improved LVEF—strong evidence for improved myocardial perfusion/circulation.
- Impact of a single intravenous administration of nicorandil before reperfusion in patients with ST-segment-elevation myocardial infarction
PubMed ID: 16116055
Peri-reperfusion nicorandil significantly improved TIMI flow, ST-resolution and reduced events after STEMI — strong evidence that K(ATP) opening enhances myocardial perfusion/circulation in this setting.
- Bolus injection of adenosine before cardioplegic induction improves postischemic global function in coronary artery bypass grafting
PubMed ID: 16450593
Adenosine bolus before cardioplegia shortened time to asystole and improved post‑op cardiac index and reduced troponin release—shows acute circulatory/contractile benefit in heart surgery.
- Detection of significant stenotic lesions in the left anterior descending coronary artery using adenosine triphosphate stress strain imaging: comparison with coronary flow velocity reserve measurement using transthoracic Doppler echocardiography
PubMed ID: 16880095
Intravenous ATP produced coronary hyperemia and differentiated ischemic vs nonischemic myocardium—direct circulatory effect.
- Beneficial effects of intracoronary nicorandil on microvascular dysfunction after primary percutaneous coronary intervention: demonstration of its superiority to nitroglycerin in a cross-over study
PubMed ID: 23722418
Randomized crossover study: nicorandil (KATP opener) markedly lowered index of microcirculatory resistance versus nitroglycerin—strong direct evidence for microvascular improvement.
- Nicorandil prevents microvascular dysfunction resulting from PCI in patients with stable angina pectoris: a randomised study
PubMed ID: 24457276
Peri-PCI nicorandil (ATP-sensitive K+ channel opener) reduced microvascular dysfunction and myocardial injury—direct vascular benefit related to ATP-sensitive mechanisms.
- Effects of adding intravenous nicorandil to standard therapy on cardiac sympathetic nerve activity and myocyte dysfunction in patients with acute decompensated heart failure
PubMed ID: 25634117
Nicorandil produced statistically and clinically significant improvements in cardiac MIBG parameters and reduced hs‑TnT—strong impact on cardiac physiology/circulation.
- Effects of caffeine on fractional flow reserve values measured using intravenous adenosine triphosphate
PubMed ID: 28110424
IV ATP provokes coronary hyperemia and was used as a hyperemic agent in FFR studies—direct human evidence that ATP increases blood flow to myocardium (strong mechanistic relevance to circulation).
- Adenosine triphosphate (ATP) and adenosine cause similar vasodilator effect in patients undergoing stress perfusion cardiac magnetic resonance imaging
PubMed ID: 30426300
Direct trial of IV ATP showing coronary vasodilation similar to adenosine and comparable perfusion indices — strong direct evidence for ATP-mediated vasodilation.
- Effect of Transcutaneous Acupoint Electrical Stimulation on Urinary Retention and Urinary ATP in Elderly Patients After Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled Clinical Trial
PubMed ID: 36479561
TEAS raised urinary ATP and reduced POUR via improved bladder/urinary outcomes (blood flow/ATP mechanistic signal)
- Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT-4202), an Allosteric Activator of Pyruvate Kinase-R, in Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, First-in-Human Phase 1 Trial
PubMed ID: 35019238
Etavopivat increased RBC ATP and altered Hb‑O2 affinity — mechanistically expected to improve tissue oxygen delivery/circulation.
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
D‑ribose/ubiquinol improved EF, BNP, and ATP markers in HFpEF — direct circulation/cardiac function relevance
- Liraglutide Improves Myocardial Perfusion and Energetics and Exercise Tolerance in Patients With Type 2 Diabetes
PubMed ID: 39084829
Liraglutide increased stress myocardial blood flow and perfusion reserve — direct evidence of improved cardiac circulation.
Muscle maintenance (16)
- Impact of a single intravenous administration of nicorandil before reperfusion in patients with ST-segment-elevation myocardial infarction
PubMed ID: 16116055
Nicorandil reduced clinical cardiac events and improved reperfusion metrics after MI — supports myocardial (muscle) health via improved perfusion/protection.
- Ferric derisomaltose augments intrinsic skeletal muscle electron transport chain activity in heart failure: A FERRIC-HF II molecular substudy
PubMed ID: 40916716
Increased complex I respiration and PCr recovery are favorable for muscle bioenergetics and overall muscle health.
- Multicenter, phase 1 study of etavopivat (FT-4202) treatment for up to 12 weeks in patients with sickle cell disease
PubMed ID: 38640200
Large increases in intracellular ATP (etavopivat) provide direct mechanistic support for cellular/muscle energetics and health.
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
D‑ribose/ubiquinol in HFpEF raised blood ATP and improved clinical measures (KCCQ, EF) — supports myocardial/muscle energetic health.
- Fermented Carica papaya and Morinda citrifolia as Perspective Food Supplements for the Treatment of Post-COVID Symptoms: Randomized Placebo-Controlled Clinical Laboratory Study
PubMed ID: 35684003
Fermented supplements restored PMN ATP and improved muscle‑related post‑COVID symptoms
- Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT-4202), an Allosteric Activator of Pyruvate Kinase-R, in Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, First-in-Human Phase 1 Trial
PubMed ID: 35019238
Etavopivat increased RBC ATP and Hb‑O2 affinity → supports muscle oxygenation/health
- Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial
PubMed ID: 35050355
Urolithin A RCT in older adults improved muscle endurance and some mitochondrial biomarkers — direct support for muscle mitochondrial health.
- In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial
PubMed ID: 34264994
Direct increase in mitochondrial ATP production (ATPmax) supports muscle energetics and health — strongest direct evidence among the supplied studies.
- Effect of Iron Isomaltoside on Skeletal Muscle Energetics in Patients With Chronic Heart Failure and Iron Deficiency
PubMed ID: 30776909
IV iron improved muscle PCr/ADP recovery kinetics, indicating improved skeletal muscle energetics relevant to muscle health.
- From mitochondria to healthy aging: The role of branched-chain amino acids treatment: MATeR a randomized study
PubMed ID: 31672329
BCAA‑enriched supplementation raised mitochondrial ATP production and modestly improved physical performance in malnourished elderly—supports muscle bioenergetics and function.
- Effects of adenosine triphosphate (ATP) on early recovery after total knee arthroplasty (TKA): a randomized, double-blind, controlled study
PubMed ID: 24813646
Oral ATP supplementation produced clinically meaningful improvements in quadriceps strength and reduced pain after TKA—direct support for muscle health in rehabilitation.
- Myocardial metabolic changes during pediatric cardiac surgery: a randomized study of 3 cardioplegic techniques
PubMed ID: 15224023
Cardioplegia study directly measured myocardial ATP and showed metabolic recovery benefits—strong support for cardiac muscle energetic health.
- Beneficial effects of adenosine triphosphate on nutritional status in advanced lung cancer patients: a randomized clinical trial
PubMed ID: 11786563
IV ATP prevented loss of fat-free mass in advanced NSCLC patients — direct clinical support for muscle-preserving effects in catabolic illness.
- Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer
PubMed ID: 10675381
Randomized IV ATP trial in advanced lung cancer preserved body weight, serum albumin and elbow-flexor strength—direct evidence supporting muscle maintenance/health.
- A clinical comparative study between crystalloid and blood-based St Thomas' hospital cardioplegic solution
PubMed ID: 10077377
Blood cardioplegia better maintained myocardial high-energy phosphates and improved early recovery → clinically relevant evidence for protecting muscle (cardiac) energetics.
- [Protective effect of cold autologous blood cardioplegic solution on the heart of infants with cyanotic congenital heart disease]
PubMed ID: 23791061
Cold autologous blood cardioplegia preserved myocardial ATP and reduced injury markers — strong support for myocardial muscle health in that surgical setting.
Workout performance (17)
- From mitochondria to healthy aging: The role of branched-chain amino acids treatment: MATeR a randomized study
PubMed ID: 31672329
Strong mechanistic increase in mitochondrial ATP production with associated modest cognitive and physical performance gains in malnourished elderly.
- Oral Adenosine-5'-triphosphate (ATP) Administration Increases Postexercise ATP Levels, Muscle Excitability, and Athletic Performance Following a Repeated Sprint Bout
PubMed ID: 28080323
Direct randomized trial of oral ATP showing preserved nucleotide pools, maintained excitability, and increased peak sprint power — strong evidence for an ergogenic effect on short‑term performance.
- Effects of adenosine triphosphate (ATP) on early recovery after total knee arthroplasty (TKA): a randomized, double-blind, controlled study
PubMed ID: 24813646
RCT of oral ATP demonstrated improved quadriceps strength and reduced pain/opioid use—supports meaningful overall functional performance gains in a rehabilitation context.
- Beneficial effects of adenosine triphosphate on nutritional status in advanced lung cancer patients: a randomized clinical trial
PubMed ID: 11786563
Repeated IV ATP in advanced NSCLC maintained energy intake, FM and FFM — strongest human evidence that ATP administration can preserve overall functional status/performance in catabolic illness.
- Large energetic adaptations of elderly muscle to resistance and endurance training
PubMed ID: 11299253
Training-induced mitochondrial and contractile adaptations produced large improvements in oxidative metabolism and size — strong exercise-mediated support for overall performance.
- Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer
PubMed ID: 10675381
IV ATP maintained weight, albumin, and muscle strength and slowed QoL decline in NSCLC patients—direct improvement in overall clinical performance.
- Preconditioning improves myocardial preservation in patients undergoing open heart operations
PubMed ID: 9386697
Ischemic preconditioning preserved myocardial ATP and improved contractility after ischemia — supports better organ performance in surgical ischemia context.
- Ferric derisomaltose augments intrinsic skeletal muscle electron transport chain activity in heart failure: A FERRIC-HF II molecular substudy
PubMed ID: 40916716
Increased mitochondrial complex I respiration and faster PCr recovery are likely to improve multiple performance domains.
- Effect of Iron Isomaltoside on Skeletal Muscle Energetics in Patients With Chronic Heart Failure and Iron Deficiency
PubMed ID: 30776909
Improved muscle energetic recovery (PCr/ADP kinetics) in HF patients is likely to translate to better functional performance.
- In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial
PubMed ID: 34264994
By increasing mitochondrial ATP production, elamipretide offers a plausible route to improved whole‑body and muscular performance; functional gains were modest but supportive.
- Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT-4202), an Allosteric Activator of Pyruvate Kinase-R, in Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, First-in-Human Phase 1 Trial
PubMed ID: 35019238
Etavopivat raised RBC ATP and increased Hb‑O2 affinity — supports improved oxygen delivery and hence overall performance, especially aerobic tasks.
- Fermented Carica papaya and Morinda citrifolia as Perspective Food Supplements for the Treatment of Post-COVID Symptoms: Randomized Placebo-Controlled Clinical Laboratory Study
PubMed ID: 35684003
Fermented supplements restored ATP and improved many post‑COVID symptoms → performance implication for affected subjects
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
D‑ribose/ubiquinol improved symptoms, EF and ATP biomarkers in HFpEF — supports improved functional performance in a disease population.
- Multicenter, phase 1 study of etavopivat (FT-4202) treatment for up to 12 weeks in patients with sickle cell disease
PubMed ID: 38640200
Etavopivat produced robust ATP and hemoglobin gains—mechanistically and clinically supportive of improved overall performance in disease states.
- Safety and efficacy of mitapivat in sickle cell disease (RISE UP): results from the phase 2 portion of a global, double-blind, randomised, placebo-controlled trial
PubMed ID: 39644907
Mitapivat increased RBC ATP/Hb with meaningful hemoglobin responses, supporting improved functional capacity.
- Product of Traditional Chinese Medicine Longgui Yangxinwan Protects the Human Body from Altitude Sickness Damage by Reducing Oxidative Stress and Preventing Mitochondrial Dysfunction
PubMed ID: 38995860
Substantial increases in blood ATP and mitochondrial function with the traditional medicine at altitude suggest potential for improved overall performance (strong ATP signal but not an oral ATP supplement).
- Optimizing rare disorder trials: a phase 1a/1b randomized study of KL1333 in adults with mitochondrial disease
PubMed ID: 39657714
Pilot functional and fatigue improvements in mitochondrial disease imply potential performance benefits where energetics are limiting.
Energy & Fatigue (15)
- Oral Adenosine-5'-triphosphate (ATP) Administration Increases Postexercise ATP Levels, Muscle Excitability, and Athletic Performance Following a Repeated Sprint Bout
PubMed ID: 28080323
ATP supplementation blunted exercise‑induced drops in adenine nucleotides and preserved muscle excitability across repeated sprints, indicating less peripheral muscle fatigue.
- Effect of a vitamin/mineral supplement on children and adults with autism
PubMed ID: 22151477
Multivitamin/mineral intervention produced a 25% plasma ATP rise and modest symptom improvement, suggesting higher circulating ATP may relate to perceived energy.
- Fermented Carica papaya and Morinda citrifolia as Perspective Food Supplements for the Treatment of Post-COVID Symptoms: Randomized Placebo-Controlled Clinical Laboratory Study
PubMed ID: 35684003
Fermented papaya/noni RCT: improved post‑COVID symptoms and restored PMN ATP content — supports reduced fatigue in this population.
- In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial
PubMed ID: 34264994
Elamipretide increased in vivo mitochondrial ATP production (ATPmax) in older adults — directly supports cellular energy generation.
- From mitochondria to healthy aging: The role of branched-chain amino acids treatment: MATeR a randomized study
PubMed ID: 31672329
BCAA‑enriched supplement increased mitochondrial ATP production in malnourished elderly—direct mechanistic link to cellular energy.
- Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?
PubMed ID: 25386668
CoQ10+NADH trial reported reduced fatigue and increased PBMC ATP in chronic fatigue syndrome—strongest direct evidence in dataset linking ATP-raising intervention to less fatigue.
- Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer
PubMed ID: 10675381
ATP infusions slowed weight/muscle strength decline and preserved QoL in NSCLC—consistent with reduced fatigue.
- Beneficial effects of adenosine triphosphate on nutritional status in advanced lung cancer patients: a randomized clinical trial
PubMed ID: 11786563
Repeated IV ATP in advanced NSCLC preserved energy intake and body composition — direct evidence for maintained daily energy/nutrition.
- [Stabilized NADH (ENADA) improves jet lag-induced cognitive performance deficit]
PubMed ID: 12385067
Sublingual NADH reduced sleepiness and improved cognitive tests after jet lag — plausible increase in subjective daily energy via improved cellular energetics.
- Optimizing rare disorder trials: a phase 1a/1b randomized study of KL1333 in adults with mitochondrial disease
PubMed ID: 39657714
Direct pilot RCT signal: KL1333 improved validated fatigue scores in mitochondrial disease patients.
- Ferric derisomaltose augments intrinsic skeletal muscle electron transport chain activity in heart failure: A FERRIC-HF II molecular substudy
PubMed ID: 40916716
Improved complex I respiration and PCr recovery suggest less exercise‑induced energetic deficit and fatigue.
- Product of Traditional Chinese Medicine Longgui Yangxinwan Protects the Human Body from Altitude Sickness Damage by Reducing Oxidative Stress and Preventing Mitochondrial Dysfunction
PubMed ID: 38995860
Longgui yangxinwan produced large increases in measured blood ATP and mitochondrial function at high altitude—supports potential for increased systemic energy (but not an oral ATP supplement; traditional medicine).
- Multicenter, phase 1 study of etavopivat (FT-4202) treatment for up to 12 weeks in patients with sickle cell disease
PubMed ID: 38640200
Large intracellular ATP increases and Hb gains in etavopivat-treated patients suggest clinically meaningful lessening of anemia-related fatigue.
- Safety and efficacy of mitapivat in sickle cell disease (RISE UP): results from the phase 2 portion of a global, double-blind, randomised, placebo-controlled trial
PubMed ID: 39644907
Mitapivat's RBC ATP/Hb effects in hemolytic disease are mechanistically linked to reduced fatigue from anemia.
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
HFpEF RCT: D‑ribose (with/without ubiquinol) raised blood ATP and produced clinically meaningful symptom/KCCQ improvements (greater perceived energy).
Endurance (13)
- Preconditioning improves myocardial preservation in patients undergoing open heart operations
PubMed ID: 9386697
Ischemic preconditioning preserved myocardial ATP and improved contractile recovery after prolonged ischemia — supports better cardiac function and oxygen delivery (surgical setting).
- Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer
PubMed ID: 10675381
Preservation of muscle strength and QoL in ATP-treated cancer patients implies improved stamina in that clinical context.
- Ferric derisomaltose augments intrinsic skeletal muscle electron transport chain activity in heart failure: A FERRIC-HF II molecular substudy
PubMed ID: 40916716
Selective increase in skeletal muscle complex I respiration and improved PCr recovery support enhanced aerobic ATP production.
- Product of Traditional Chinese Medicine Longgui Yangxinwan Protects the Human Body from Altitude Sickness Damage by Reducing Oxidative Stress and Preventing Mitochondrial Dysfunction
PubMed ID: 38995860
Large reported increases in systemic ATP and mitochondrial markers with the tested medicine are consistent with better stamina, though not from exogenous ATP.
- Multicenter, phase 1 study of etavopivat (FT-4202) treatment for up to 12 weeks in patients with sickle cell disease
PubMed ID: 38640200
Etavopivat's ATP and Hb increases are consistent with improved sustained exercise capacity (stamina).
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
D‑ribose/ubiquinol raised ATP markers and symptom scores → stamina relevance
- Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT-4202), an Allosteric Activator of Pyruvate Kinase-R, in Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, First-in-Human Phase 1 Trial
PubMed ID: 35019238
Etavopivat increased RBC ATP and decreased 2,3‑DPG raising Hb‑O2 affinity — mechanistically supports improved O2 delivery and aerobic capacity.
- Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial
PubMed ID: 35050355
Urolithin A improved muscle endurance in older adults and some mitochondrial biomarkers — supports improved stamina.
- In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial
PubMed ID: 34264994
Elamipretide increased ATPmax and had signals consistent with improved mitochondrial function, a key determinant of aerobic capacity.
- Effect of Iron Isomaltoside on Skeletal Muscle Energetics in Patients With Chronic Heart Failure and Iron Deficiency
PubMed ID: 30776909
Faster PCr/ADP recovery and improved muscle energetics support repeated efforts / stamina.
- From mitochondria to healthy aging: The role of branched-chain amino acids treatment: MATeR a randomized study
PubMed ID: 31672329
Enhanced mitochondrial ATP production and modest physical performance gains support improved stamina potential.
- Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy
PubMed ID: 20921440
Perhexiline produced a measurable increase in peak VO2 and improved PCr/ATP ratio → relatively strong direct evidence for improved aerobic capacity for that metabolic intervention.
- Large energetic adaptations of elderly muscle to resistance and endurance training
PubMed ID: 11299253
Training-induced increases in oxidative capacity strongly support improved stamina (exercise effect rather than ATP supplement).
Nutrient uptake (9)
- Comparative effects of nicorandil with isosorbide mononitrate on cardiac sympathetic nerve activity and left ventricular function in patients with ischemic cardiomyopathy
PubMed ID: 16169327
Improved cardiac output and reduced LVEDV suggest improved systemic perfusion and hence nutrient delivery to tissues.
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
D‑ribose/ubiquinol improved EF and ATP markers → better cardiac output/nutrient delivery in HFpEF
- Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT-4202), an Allosteric Activator of Pyruvate Kinase-R, in Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, First-in-Human Phase 1 Trial
PubMed ID: 35019238
Etavopivat's increase in RBC ATP and altered Hb‑O2 affinity likely improves oxygen and nutrient unloading/delivery to tissues.
- Effects of adding intravenous nicorandil to standard therapy on cardiac sympathetic nerve activity and myocyte dysfunction in patients with acute decompensated heart failure
PubMed ID: 25634117
Nicorandil's improvement in cardiac sympathetic function and reduced myocyte injury implies better myocardial perfusion/nutrient delivery.
- Impact of a single intravenous administration of nicorandil before reperfusion in patients with ST-segment-elevation myocardial infarction
PubMed ID: 16116055
Nicorandil increased post-procedural TIMI3 flow and ST-resolution after MI — improved coronary blood flow implies improved nutrient/oxygen delivery to myocardium.
- Nicorandil improves cardiac function and clinical outcome in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: role of inhibitory effect on reactive oxygen species formation
PubMed ID: 15459610
Nicorandil reduced no-reflow and improved LVEF after MI, consistent with better microvascular perfusion and nutrient delivery to myocardium.
- Beneficial effects of adenosine triphosphate on nutritional status in advanced lung cancer patients: a randomized clinical trial
PubMed ID: 11786563
Repeated IV ATP infusions in advanced NSCLC prevented loss of fat mass/FFM and maintained energy intake — strongest evidence for improved nutrient intake/delivery in humans receiving IV ATP.
- Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction
PubMed ID: 10080465
Nicorandil improved microvascular integrity after MI, which would enhance tissue nutrient delivery.
- Comparison of adenosine triphosphate and dipyridamole in diagnosis by thallium-201 myocardial scintigraphy
PubMed ID: 9098205
Increased coronary flow reserve from IV ATP implies improved delivery of blood-borne nutrients to myocardium in acute settings.
Exercise recovery (4)
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
PubMed ID: 35644694
D‑ribose (with ubiquinol) lowered lactate/ATP ratio and increased ATP biomarkers in HFpEF — consistent with improved energetic recovery.
- Effects of adenosine triphosphate (ATP) on early recovery after total knee arthroplasty (TKA): a randomized, double-blind, controlled study
PubMed ID: 24813646
Oral ATP improved early postoperative quadriceps strength and reduced pain/opioid use—clinical evidence for accelerated muscle recovery in a rehabilitation context.
- Effect of Iron Isomaltoside on Skeletal Muscle Energetics in Patients With Chronic Heart Failure and Iron Deficiency
PubMed ID: 30776909
IV iron shortened PCr and ADP recovery half‑times in skeletal muscle—direct evidence of faster bioenergetic recovery after exertion.
- Ferric derisomaltose augments intrinsic skeletal muscle electron transport chain activity in heart failure: A FERRIC-HF II molecular substudy
PubMed ID: 40916716
IV iron accelerated PCr recovery halftime and increased complex I respiration—direct mechanistic evidence for faster energetic recovery.
Strength (4)
- Effects of adenosine triphosphate (ATP) on early recovery after total knee arthroplasty (TKA): a randomized, double-blind, controlled study
PubMed ID: 24813646
Randomized, double‑blind RCT of oral ATP (120 mg/day) showed significant improvements in quadriceps strength after TKA (direct clinical evidence).
- Beneficial effects of adenosine triphosphate on nutritional status in advanced lung cancer patients: a randomized clinical trial
PubMed ID: 11786563
IV ATP in cancer preserved fat-free mass (muscle) — reasonably supportive of maintaining strength in cachectic patients.
- Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer
PubMed ID: 10675381
Randomized IV ATP trial showed preserved elbow-flexor strength over time in NSCLC patients (direct evidence).
- Oral Adenosine-5'-triphosphate (ATP) Administration Increases Postexercise ATP Levels, Muscle Excitability, and Athletic Performance Following a Repeated Sprint Bout
PubMed ID: 28080323
Oral ATP significantly increased Wingate peak power in later repeated sprints — direct evidence of enhanced power output.
Metabolism (3)
- Beneficial effects of adenosine triphosphate on nutritional status in advanced lung cancer patients: a randomized clinical trial
PubMed ID: 11786563
IV ATP maintained energy intake and prevented FFM loss in cancer — clear evidence of altering whole-body metabolic balance in catabolic illness.
- Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT-4202), an Allosteric Activator of Pyruvate Kinase-R, in Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, First-in-Human Phase 1 Trial
PubMed ID: 35019238
Etavopivat raised RBC ATP and altered glycolytic byproducts (2,3‑DPG) affecting systemic O2 metabolism
- From mitochondria to healthy aging: The role of branched-chain amino acids treatment: MATeR a randomized study
PubMed ID: 31672329
Increased mitochondrial ATP production and electron flux indicate upregulated cellular metabolic capacity in treated elderly.
Focus & concentration (2)
- [Stabilized NADH (ENADA) improves jet lag-induced cognitive performance deficit]
PubMed ID: 12385067
Same RCT showed improved cognitive test performance and less sleepiness, consistent with clearer concentration.
- From mitochondria to healthy aging: The role of branched-chain amino acids treatment: MATeR a randomized study
PubMed ID: 31672329
MMSE cognitive score improved modestly alongside increased mitochondrial ATP production—suggests cognitive benefit in malnourished elderly.
Muscle soreness (1)
- Effects of adenosine triphosphate (ATP) on early recovery after total knee arthroplasty (TKA): a randomized, double-blind, controlled study
PubMed ID: 24813646
Postoperative pain was reduced with oral ATP in the RCT, which is relevant to muscle soreness reduction (surgical model, not exercise DOMS).
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with ATP
Search all122 products whose verified label declares ATP — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.