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Vitamin D and Zinc: study protocols

22 study groups took Vitamin D together with Zinc. These are the doses the studies gave. They are not a recommendation.

Vitamin D: what the research found →

Dose per serving from research: Vitamin D

14 study groups in 12 studies say how much Vitamin D participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg and 5 mcg to 10 mcg and 10 mcg to 25 mcg, 29% of 14 study groups each.

Daily doseStudy groups
1 mcg or less
1
1 mcg to 2.5 mcg
1
2.5 mcg to 5 mcg
4
5 mcg to 10 mcg
4
10 mcg to 25 mcg
4

Dose per serving from research: Zinc

22 study groups in 20 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 32% of 22 study groups.

Daily doseStudy groups
1 mg to 2.5 mg
4
2.5 mg to 5 mg
2
5 mg to 10 mg
6
10 mg to 25 mg
7
25 mg to 50 mg
3

Commonly used together

20 of 22 study groups took Vitamin D and Zinc with something else. Shown: what 3 or more different studies gave. The 10 most common of 15.

What was given together, not what works together.

Taken withStudy groups
Calcium
9
Magnesium
9
Vitamin B12
9
Iron
7
Vitamin C
7
Copper
6
Folic Acid
6
Selenium
6
Vitamin A
6
Vitamin B6
6

22 study groups

Study
Novel Chewable Pleuran-Based Supplement Decreases Respiratory Tract Infections in Children: A Randomised Controlled Trial
2025 · active placebo group · Children aged 3–18 years with a documented history of recurrent respiratory tract infections
10 mcg5 mg90 days113
Novel Chewable Pleuran-Based Supplement Decreases Respiratory Tract Infections in Children: A Randomised Controlled Trial
2025 · active group · Children aged 3–18 years with a documented history of recurrent respiratory tract infections
10 mcg5 mg90 days104
Effect of an Immune-Boosting, Antioxidant and Anti-Inflammatory Food Supplement in Hospitalized COVID-19 Patients: A Prospective Randomized Pilot Study
2023 · intervention group · Adults aged 18 years or older hospitalized with PCR-confirmed COVID-19 who required more than 48 hours of admission
0.75 mcg1.5 mg—78
Effects of multimicronutrient supplementation on helminth reinfection: a randomized, controlled trial in Kenyan schoolchildren
2003 · multimicronutrient supplementation · Schoolchildren in Nyanza Province, Kenya; age and sex not specified
5 mcg20 mg335 days—
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
10 mcg30 mg——
Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial
2020 · Vitamin D plus zinc group · Overweight or obese adults with depressive symptoms and BDI-II score ≥10; mean age 38.35 years
2,000 IU30 mg12 weeks—
Melatonin, vitamins and minerals supplements for the treatment of Covid-19 and Covid-like illness: A prospective, randomized, double-blind multicenter study
2024 · Treatment group · Adults younger than 60 years with COVID-19 or COVID-like illness, no previous medical history, and not hospitalized
2.5 mcg25 mg—82
Effect of zinc plus multivitamin supplementation on growth in school children
2016 · Chelated zinc plus multivitamins · Healthy Thai schoolchildren aged 4–13 years
200 IU20 mg26 weeks70
Effects of Low-Dose Dairy Protein Plus Micronutrient Supplementation during Resistance Exercise on Muscle Mass and Physical Performance in Older Adults: A Randomized, Controlled Trial
2018 · ExPM (resistance exercise plus low-dose dairy protein and micronutrient supplementation) · Adults aged 65–80 years, non-disabled and not exercising regularly
5 mcg8 mg12 weeks40
Magnesium-Zinc-Calcium-Vitamin D Co-supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial
2018 · Magnesium-zinc-calcium-vitamin D co-supplementation · Women with polycystic ovary syndrome (PCOS); age not reported
400 IU8 mg12 weeks30
A prospective randomized comparative trial evaluating postoperative nutritional intervention in patients with oral cancer
2022 · Intervention group · Adults with oral cancer after surgery; ages 18 and older, both sexes
2,857 IU40 mg26 weeks22
Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study
2022 · Treatment group · Children aged 6–17 years with obesity (BMI above the 95th percentile for age)
25 mcg7 mg26 weeks16
Effects of Macuprev(®) Supplementation in Age-Related Macular Degeneration: A Double-Blind Randomized Morpho-Functional Study Along 6 Months of Follow-Up
2019 · AMD-M group · Adults with intermediate age-related macular degeneration; 9 male and 21 female enrolled overall, mean age 69.32 years
800 IU16 mg26 weeks15
[Vitrum osteomag in prevention of osteoporosis in postmenopausal women: results of the comparative open multicenter trial]
2004 · Group 1: Vitrum Osteomag · Postmenopausal women with osteopenia; age range not reported
400 IU15 mg1 year125
Calcium and vitamin D fortified milk reduces bone turnover and improves bone density in postmenopausal women over 1 year
2018 · intervention · Chinese postmenopausal women in Malaysia; mean age 59 years
15 mcg2.4 mg1 year61
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
10 mcg10 mg—870
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
5 mcg12 mg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
5 mcg12 mg—176
A Trial on The Effects of Magnesium-Zinc-Calcium-Vitamin D Co-Supplementation on Glycemic Control and Markers of Cardio-Metabolic Risk in Women with Polycystic Ovary Syndrome
2017 · Magnesium-zinc-calcium-vitamin D co-supplementation · Women with polycystic ovary syndrome (PCOS)
400 IU8 mg12 weeks30
The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes
2019 · Magnesium-zinc-calcium-vitamin D group · Women aged 18–40 with gestational diabetes mellitus, at 24–28 weeks’ gestation at diagnosis
400 IU8 mg6 weeks30
Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women
2016 · Intervention (Int), premenopausal women · Premenopausal women, mean age 41 years; no specific condition stated
15 mcg2.4 mg12 weeks—
Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women
2016 · Intervention (Int), postmenopausal women · Postmenopausal women, mean age 59 years; no specific condition stated
15 mcg2.4 mg12 weeks—
Vitamin D and Zinc: study protocols | supp.fit