Calcium

PubMed ID: 40548492

10-year RA cohort all given daily calcium+vitamin D showed minimal bone loss—strong evidence for Ca supporting long-term BMD maintenance in a high-risk group.

PubMed ID: 21185977

Sustained dietary increases in calcium and vitamin D intake—supports bone density maintenance.

PubMed ID: 21466595

Calcium + vitamin D given post‑transplant associated with increases in spine BMD—evidence that supplementation aids skeletal recovery and wellbeing.

PubMed ID: 21648282

Prepubertal children receiving hydrolysed collagen plus calcium showed larger increases in growth- and bone-turnover markers vs collagen alone/placebo (direct pediatric bone-growth relevance).

PubMed ID: 21860562

Calcium + vitamin D used as baseline therapy in postmenopausal women; BMD improvements with adjunct therapies imply that Ca/D supports skeletal wellbeing.

PubMed ID: 21932114

Large bisphosphonate study where daily calcium was provided to all—BMD increases observed as part of osteoporosis management.

PubMed ID: 21909466

Randomized clinical study: injectable calcium sulfate used to fill surgical bone defects showed predictable resorption and comparable healing vs DBM—strong direct evidence for bone healing.

PubMed ID: 21364273

Robust randomized data showing enhanced BMD and bone strength with active vitamin D on top of alendronate + calcium—strong support for skeletal health in that setting.

PubMed ID: 22166162

Calcium sulfate graft cleared faster and produced significantly more new bone (~32% vs 16.7%) at ≈3 months — strong clinical evidence for a calcium‑based graft aiding bone healing.

PubMed ID: 22174164

Adolescent girls receiving quarterly vitamin D showed dose‑dependent rise in 25(OH)D — relevant to supporting bone mineral accrual during growth (indirect to calcium).

PubMed ID: 21600042

Trial of β‑TCP graft in distal radius fractures tested Ca‑phosphate graft for healing but showed no clinical/radiographic advantage—high relevance though negative result.

PubMed ID: 21644308

Trial included an oral oyster‑shell/calcium carbonate product for primary osteoporosis—direct bone relevance (though inferior to moxibustion in that trial).

PubMed ID: 21328040

Intervention in adolescent survivors substantially increased milk consumption and calcium supplementation — strongly relevant to supporting bone accrual during adolescence (behavioral endpoint, no direct bone measurement).

PubMed ID: 22168624

Biphasic calcium phosphate grafts supported bone formation after sinus augmentation and enabled implant placement, indicating substantial bone‑healing/osseointegration utility.

PubMed ID: 21557757

Local bone augmentation using biphasic calcium phosphate graft led to significant lateral/vertical mineralized tissue gains — directly relevant to bone healing/augmentation.

PubMed ID: 22653713

Direct RCT: 500 mg/day calcium slowed lumbar spine BMD loss versus placebo in women with low baseline intake.

PubMed ID: 23208074

WHI Ca+D RCT showed a subgroup (non‑users of personal supplements over long-term) hip fracture reduction — strongest trial-level evidence linking supplementation to fracture risk reduction.

PubMed ID: 23224626

During GH therapy, adding zinc to calcium+vitamin D produced slightly larger bone mass gains vs calcium+vit D alone — calcium included and results indicate modest support for bone accrual.

PubMed ID: 23498210

β‑tricalcium phosphate grafts supported new bone formation in solitary bone cysts and performed similarly to allograft — strong evidence for local calcium-based graft aiding bone healing.

PubMed ID: 23276888

Zoledronic acid + Ca/vitD prevented BMD loss in lymphoma patients; Ca/vitD were standard adjuncts supporting bone density maintenance.

PubMed ID: 23104564

RCT in children with nutritional rickets: combined calcium + vitamin D produced markedly better radiological and biochemical healing.

PubMed ID: 22644348

High‑calcium vitamin D fortified milk lowered bone turnover markers and PTH in postmenopausal women—supports bone density maintenance physiology.

PubMed ID: 23163915

Alveolar ridge preservation after extraction using graft material reduced ridge loss vs spontaneous healing—direct oral bone‑healing outcome.

PubMed ID: 22946930

After kidney transplant, patients receiving calcium+calcitriol maintained BMD; calcium part of regimen that preserved density.

PubMed ID: 22309243

Calcium‑enriched endodontic cement promoted apexogenesis/root development — a form of local hard‑tissue healing.

PubMed ID: 22282300

Randomized study: adding 250 mg Ca/day via fortified milk prevented hip and femoral neck BMD loss in postmenopausal women — strong direct evidence for maintaining bone density.

PubMed ID: 22538473

Human sinus augmentation trial: adding calcium‑containing substitutes to autograft produced similar new bone volume — direct clinical evidence for calcium‑containing graft materials aiding bone regeneration.

PubMed ID: 22866291

Randomized trial of implants with nanostructured calcium‑incorporated surface showed comparable performance to longer augmented implants — supports calcium surface facilitating osseointegration/healing.

PubMed ID: 23221739

Calcifediol in dialysis increased serum calcium and lowered PTH — relevant to bone mineral metabolism and potential effects on bone density in CKD patients.

PubMed ID: 22357739

Calcium+vitamin D fortified cheese reduced a bone resorption marker and raised IGF‑I — biomarker evidence supportive of bone density maintenance.

PubMed ID: 22426307

Teriparatide trials included 1000 mg Ca/day with measurable bone‑metabolism changes — supports calcium as part of bone‑density maintenance in therapy contexts.

PubMed ID: 22612371

Addition of hydroxyapatite/β‑TCP (calcium‑phosphate) to periodontal regeneration produced significantly greater radiographic bone gain and clinical attachment recovery — strong evidence that calcium‑based grafts aid bone healing.

PubMed ID: 23062766

MK‑7 improved carboxylation of bone calcium‑binding proteins (osteocalcin/MGP), indirectly supporting mineralization and bone density via better Ca‑binding function.

PubMed ID: 22551881

Combined calcium + vitamin D attenuated wrist BMD loss in elderly women over 24 months (direct bone density outcome; attribution to calcium alone is limited).

PubMed ID: 23168135

Iliac crest donor‑site defects filled with a calcium‑phosphate graft showed improved medullary defect repair on CT—strong evidence for localized calcium‑based grafts aiding bone repair.

PubMed ID: 22855333

Dose-ranging vitamin D increased fractional intestinal calcium absorption — a key mechanism supporting bone mineralization.

PubMed ID: 22901550

Adolescent study found higher milk/calcium intake associated with greater bone mass — direct support for calcium in growing skeletons.

PubMed ID: 23189308

Sinus augmentation study: grafted sites (including calcium‑based substitutes such as HA/β‑TCP) increased bone density after healing, supporting local bone healing applications of calcium materials.

PubMed ID: 22052452

Calcimimetic increased trabecular/spine vBMD, supporting an effect on maintaining/increasing bone density (site‑specific).

PubMed ID: 23477205

Calcium (tablet) vs dairy in adolescent mothers tracked BMD/BMC postpartum—direct to maintaining bone mass.

PubMed ID: 22990031

Randomized prepubertal calcium tablets produced earlier peak height velocity and altered adolescent/adult stature in boys (direct growth outcome).

PubMed ID: 22503722

Cluster randomized trial in premenarchal Indian girls: 500 mg/day calcium ± micronutrients increased total‑body bone mineral accrual and improved bone Z‑scores — direct pediatric bone growth evidence.

PubMed ID: 22387567

Large randomized trial in hemodialysis patients showed paricalcitol affected PTH and bone markers (directly relevant to calcium/P metabolism and bone turnover) — applicable to bone density in that population.

PubMed ID: 22892064

Biphasic calcium phosphate graft with fibrin produced ~20% new bone at 6 months and high implant success—strong direct evidence of bone healing support.

PubMed ID: 23072081

In older osteoporotic patients, a calcium carbonate + D3 arm showed specific vertebral index improvement, suggesting effects on spinal bone metrics.

PubMed ID: 22874110

In dialysis patients, calcium carbonate reduced PTH (which can reduce bone turnover) and raised serum calcium—evidence of calcium's substantial impact on bone-regulating hormones.

PubMed ID: 23010962

Direct human observational data linking intestinal calcium absorption to femoral neck aBMD, a primary marker for maintenance of bone density.

PubMed ID: 22295813

Elderly trial reported favorable changes in bone metabolism markers after oral calcium carbonate + vitamin D treatment.

PubMed ID: 22040002

Six‑year follow‑up showing lumbar spine BMD increase in a human cohort — directly relevant to bone density maintenance, albeit not from calcium supplementation.

PubMed ID: 22585090

Large study context of postmenopausal women on calcium+vitamin D and predictors of 25(OH)D response — relevant to maintaining bone density with supplementation.

PubMed ID: 22612364

PDGF added to β‑TCP scaffold produced significantly greater bone fill and linear bone growth in periodontal defects — strong evidence for a calcium‑phosphate scaffold aiding bone healing.

PubMed ID: 22324456

Randomized human sinus augmentation comparing calcium‑containing grafts produced measurable new bone — directly relevant to bone healing/regeneration.

PubMed ID: 22161686

PTH(1-84) on background calcium/vitamin D produced a +12.8% lumbar spine vBMD and marked microstructural changes — directly relevant to maintaining/increasing BMD in patients receiving calcium.

PubMed ID: 22676715

Infant formula trials compared calcium source while maintaining equal calcium amounts and showed normal growth — directly relevant to bone growth in infants.

PubMed ID: 22685164

After hip fracture, adding an oral nutritional supplement (background calcium/vitamin D given to all) reduced weight loss and infections and shortened rehab — supports bone-healing context during recovery.

PubMed ID: 22625182

Community feeding education increased dietary calcium intake in children and improved growth metrics — direct evidence linking increased calcium intake to child growth.

PubMed ID: 22750403

Four years risedronate trial used calcium/vitamin D background and demonstrated durable BMD increases — calcium was part of standard supplementation.

PubMed ID: 22641239

Denosumab trial with calcium+D increased BMD across sites — calcium included as background supportive therapy.

PubMed ID: 23113482

Zoledronic acid trial (all on calcium+D) produced a large reduction in vertebral fractures — calcium was background; supports fracture‑prevention context.

PubMed ID: 22777865

Long odanacatib trial administered calcium+D and produced BMD increases — calcium was background therapy relevant to skeletal wellbeing.

PubMed ID: 22353022

Alendronate increased BMD in HIV patients who all received calcium and vitamin D — calcium was part of regimen supporting skeletal health.

PubMed ID: 23040208

Alendronate prevented bone loss in men on ADT; calcium+D was background — supports skeletal outcomes in context of calcium supplementation.

PubMed ID: 23681085

500 mg/day elemental calcium in older women preserved/increased lumbar spine BMD over 2 years—direct evidence.

PubMed ID: 24064695

RCT of 1200 mg/day calcium reduced bone turnover markers—strong direct evidence for maintaining bone density.

PubMed ID: 23507173

Prebiotic GOS increased fractional calcium absorption in adolescent girls (+13% at 5 g/day) — supports improved calcium uptake during growth.

PubMed ID: 23653431

Elderly women consuming calcium+vitamin D fortified yogurt had marked declines in PTH and bone resorption markers over 2 months — strong biochemical evidence supportive of preserved bone density.

PubMed ID: 24114400

Large randomized trial with 5‑yr calcium supplementation and 10‑yr follow‑up showed significantly fewer forearm (HR 0.62) and vertebral (HR 0.52) fractures — direct evidence for reduced fracture risk at specific sites.

PubMed ID: 24429202

In young cystic fibrosis patients, correcting calcium intake plus calcifediol led to clinically meaningful increases in lumbar spine BMAD in a subset — direct evidence of maintaining/increasing bone density.

PubMed ID: 24367946

Infant formulas containing palm olein reduced calcium absorption and retention vs formulas without palm olein — direct negative impact on calcium availability for infant bone growth.

PubMed ID: 23444134

Silicate calcium‑phosphate graft produced complete spinal fusion comparable to rhBMP‑2 at 36 months — demonstrates calcium scaffold's capability to support bone healing/fusion long‑term.

PubMed ID: 23364004

Vitamin D supplementation in postmenopausal women (with controlled 1.2 g/day calcium) increased true fractional calcium absorption — supports mechanisms that help maintain BMD.

PubMed ID: 23719547

Clear improvements in maternal spine BMD/BMC and reduced lactation-related bone loss with Ca+D—strong general skeletal benefit.

PubMed ID: 23199009

Calcitriol+cholecalciferol reduced bone turnover markers, consistent with net bone formation supporting BMD maintenance.

PubMed ID: 24010637

In men on antiepileptics, Ca+D improved BMD for most; addition of bisphosphonate produced larger spine gains.

PubMed ID: 24146170

Risedronate trial with calcium/vitamin D as background therapy showed spine BMD gains—directly relevant for maintaining bone density.

PubMed ID: 24335055

Dose-response vitamin D study showed increased calcium absorption—fundamental mechanism supporting overall skeletal health.

PubMed ID: 23881439

Alendronate study (calcium co-administered) increased BMD—calcium included as standard bone-supportive therapy.

PubMed ID: 23462943

Higher dairy/calcium intake increased bone mineral content, supporting general skeletal health.

PubMed ID: 23902782

Pregnancy Ca (1500 mg/d) produced sustained reductions in maternal BMC/BMD — directly relevant (negative impact on BMD).

PubMed ID: 24157403

Calcium‑rich milk + exercise increased femoral‑neck BMD in children — supports maintaining/increasing BMD.

PubMed ID: 24131320

Large randomized Ca+D supplementation study reduced vertebral fractures (significant effect).

PubMed ID: 23628132

Vitamin D in deficient pregnant women raised neonatal calcium and 25(OH)D — supports neonatal mineral status, relevant to infant bone growth.

PubMed ID: 23591713

Vitamin D increased forearm BMD modestly; relevant to bone density maintenance in context of calcium/vitamin D interaction.

PubMed ID: 23902955

Preterm infants receiving mineral- and vitamin D–enriched formula had greater bone mineral accretion by 6 months—direct support for bone growth in infants.

PubMed ID: 22991267

Potassium citrate produced a substantial improvement in net calcium balance in older adults—directly supports calcium retention and bone density maintenance.

PubMed ID: 24315409

Education increased proportion reporting adequate calcium intake — direct behavior likely to maintain BMD in peri‑/postmenopausal women.

PubMed ID: 23259702

Weekly teriparatide substantially reduced vertebral fractures with sustained benefit; calcium/VitD were background supplements.

PubMed ID: 23652464

10-year community intervention produced ~55% relative reduction in hip fractures while increasing calcium/vitamin D uptake—direct evidence for lower fracture risk.

PubMed ID: 24153341

Linear programming showed some complementary foods can meet calcium RNI for 6–11 month infants — supports dietary provision for bone growth in infants (modeling, not outcomes).

PubMed ID: 23824386

rhPDGF-BB with β-tricalcium phosphate matched autograft for hindfoot/ankle fusion, directly demonstrating efficacy of a calcium-phosphate graft substitute in bone healing.

PubMed ID: 23324964

Clinical study of β‑tricalcium phosphate (a calcium phosphate bone graft substitute) showed significant trabeculation and graft remodeling over two years—strong direct evidence for local calcium material aiding bone healing.

PubMed ID: 24018253

Education intervention produced increased BMD and changes in calcium/PTH — direct evidence of maintaining/improving bone density (behavioral intervention rather than Ca supplement).

PubMed ID: 23440323

Validation of thoracic BMD measurement on CT scans — directly relevant to assessment and tracking of bone density.

PubMed ID: 23460234

12‑week milk fortification in 10–14 y olds substantially raised 25(OH)D and likely improved conditions for calcium absorption and bone growth (indirect but relevant).

PubMed ID: 23989256

Elderly fracture population received 1200 mg Ca/day alongside treatment—directly relevant to bone mineral support in a high‑risk group though not isolated.

PubMed ID: 24162260

Denosumab delayed skeletal-related events in bone-metastasis patients; trial highlighted importance of calcium supplementation and showed hypocalcemia risk—relevant to bone mineral homeostasis.

PubMed ID: 23585346

Vitamin D (affecting Ca metabolism) at 1000 IU reduced hip BMD loss—directly relevant to maintaining BMD.

PubMed ID: 24113197

Raloxifene increased spine BMD in patients receiving calcium/vitamin D background therapy—shows BMD benefit in that supplementation context.

PubMed ID: 23438494

Adolescents with recent-onset type 2 diabetes had diets very low in calcium—directly relevant to bone accrual and growth in youth.

PubMed ID: 25274192

Oral calcium preparations reduced bone resorption and sustained serum Ca increases — strong general evidence for skeletal effects of oral Ca.

PubMed ID: 24253788

Randomized MIS TLIF trial compared calcium phosphate graft (Actifuse) vs rhBMP‑2 for spinal fusion; directly assesses a Ca‑based graft's effect on bone healing (inferior fusion rate).

PubMed ID: 25511814

Large pregnancy RCT: daily calcium reduced urinary NTx (bone resorption) and improved a bone surrogate in compliant women.

PubMed ID: 25314004

Randomized trial: calcium‑collagen chelate slowed whole‑body BMD loss and reduced bone resorption markers in osteopenic postmenopausal women.

PubMed ID: 25231677

Randomized calcium 1200 mg/day trial in older men produced a modest residual total‑body BMD benefit after stopping supplements—direct bone density evidence.

PubMed ID: 24872223

Adolescent metabolic balance study demonstrated dose‑responsive increases in skeletal calcium retention—direct support for bone accrual in youth.

PubMed ID: 24748637

Randomized treatment of calcium‑deficiency rickets in children showed faster radiographic healing when vitamin D was added to calcium—direct pediatric bone‑growth evidence.

PubMed ID: 24414607

Calcium + vitamin D prevented steroid‑associated lumbar spine BMC loss in children—strong, direct maintenance of bone mass.

PubMed ID: 25118085

Calcium+vitamin D during military training preserved PTH and increased vBMD/cortical measures — strong evidence for maintaining bone density under stress.

PubMed ID: 24453130

800 mg/day calcium changed bone turnover markers and slowed BMD loss in an osteopenic subgroup — supports maintenance of bone density.

PubMed ID: 24576866

Timed calcium intake around exercise reduced PTH/CTX spikes that drive bone resorption — supports strategies to maintain bone density.

PubMed ID: 24600660

β-tricalcium phosphate scaffold used with growth factor improved root coverage in periodontal defects—direct evidence of Ca-containing scaffold aiding craniofacial bone/regenerative healing.

PubMed ID: 25231730

Randomized dose-response Ca trial in adolescents significantly increased femoral neck BMC—strong direct evidence supporting bone growth.

PubMed ID: 24844611

Two-year milk-based Ca supplementation during puberty produced significant hip and femoral neck BMD accretion—directly supports bone growth.

PubMed ID: 24488080

Two-year Ca+D produced PTH decreases and altered sclerostin—relevant to bone remodeling and overall skeletal health.

PubMed ID: 25373935

Infant formula with oligofructose reduced fecal calcium losses—improves calcium retention important for infant bone mineralization.

PubMed ID: 25454818

Randomized clinical evaluation showed nanocrystalline and medical‑grade calcium sulfate grafts produced similar and substantial new bone at 4 months after extraction—direct bone‑healing evidence.

PubMed ID: 23799356

Large WHI randomized data show Ca+D reduced hip fractures especially in conjunction with hormone therapy—direct, clinically meaningful evidence.

PubMed ID: 24325663

β‑TCP and bovine bone grafts used in sinus lifts showed graft remodeling and maintenance of height indicating healing potential.

PubMed ID: 25029424

Paricalcitol in XLH improved PTH exposure and phosphate handling — relevant to pediatric bone growth in a genetic rickets disorder.

PubMed ID: 24115138

Patients receiving calcium (± vitamin D) after parathyroidectomy gained BMD at spine/hip over one year.

PubMed ID: 25467231

Endodontic comparison where Ca(OH)2 affected apical closure and fracture outcomes vs MTA — relevant to dentoalveolar bone healing.

PubMed ID: 25432324

Calcium sulfate/DBM filler matched autograft for spinal fusion with less blood loss/donor-site morbidity — strong clinical bone-healing relevance.

PubMed ID: 24762110

Direct RCT: 1 year Ca supplement in prepubertal Gambian boys advanced timing of adolescent bone-growth spurt — strong evidence for influencing pediatric bone growth timing.

PubMed ID: 25733629

Complementary-feeding program increased children's Ca intake (though still below requirements) — programmatically relevant to supporting growth.

PubMed ID: 25265123

Extraction-socket grafting with calcium-containing materials (β-TCP) improved bone quality and reduced poor-quality bone — strong direct evidence for aiding bone healing.

PubMed ID: 25391190

Study in VLBW infants comparing fortified human milk vs formula (includes Ca/P fortification) — directly relevant to infant growth/mineral status.

PubMed ID: 24527713

Provision of PTH reference limits by vitamin D and BMI status is directly relevant to assessing and managing factors that maintain bone density.

PubMed ID: 24131674

Paricalcitol markedly lowered iPTH in dialysis patients — relevant to preserving bone density via PTH control in bone-mineral disorder.

PubMed ID: 25323601

Associations between bone density/fractures and mortality support the centrality of skeletal health to overall wellbeing.

PubMed ID: 25073446

Different calcium-containing grafts produced higher implant insertion torques indicating stronger regenerated bone — supports bone healing/repair.

PubMed ID: 24150200

Randomized supplementation (including 500 mg Ca/day) in underprivileged girls significantly increased height velocity and height-for-age Z-score over 1 year; directly relevant.

PubMed ID: 24683578

Dental extraction/graft histology study used calcium-containing graft materials showing altered graft turnover and new bone formation — direct evidence for local bone healing with calcium-based grafts.

PubMed ID: 25112087

Daily calcium (caltrate 600 mg) group showed increased BMD; directly supports maintaining bone density (though adjunct therapy confounds).

PubMed ID: 24849736

Multivitamin/mineral trial that included calcium (~324 mg/day) showed a substantial reduction in fractures in men — calcium may have contributed though effect is confounded by other nutrients.

PubMed ID: 25923487

Calcium+vitamin D fortified yogurt raised 25(OH)D, lowered PTH and reduced bone resorption markers in older women (3 months).

PubMed ID: 25848134

rhPDGF-BB/β-TCP-collagen (calcium-phosphate matrix) produced higher fusion rates and faster time to fusion versus autograft in hindfoot/ankle surgery — strong evidence for calcium-containing materials in bone healing.

PubMed ID: 26264387

High-calcium/vitamin D fortified milk reduced bone turnover markers in pre/postmenopausal women over 12 weeks — favorable to BMD preservation.

PubMed ID: 26438518

Two-year randomized trial: 900 mg/day calcium (with 800 IU vitamin D) slowed bone loss at the greater trochanter in postmenopausal women — strong evidence for maintaining BMD.

PubMed ID: 26075752

High-dose vitamin D + 1000 mg Ca reduced hip and spine BMD loss by ~50% in HIV patients starting ART—strong evidence for preserving BMD.

PubMed ID: 25970439

A high-calcium pre-exercise meal attenuated exercise-induced CTX-I rises (less acute bone resorption), supportive of BMD maintenance mechanisms.

PubMed ID: 25626413

Two-year high-calcium milk RCT slowed lumbar spine BMD loss in postmenopausal women.

PubMed ID: 25710953

Calcium-silicate pulp-capping material showed more radiographic healing on CBCT vs control—evidence of improved hard-tissue healing.

PubMed ID: 24528807

Lipid-based nutrient supplements increased calcium intake in underweight young children vs controls—directly increases calcium supply for growth.

PubMed ID: 25799193

Direct randomized treatment of nutritional calcium deficiency rickets in children with clear radiographic healing—strong, child‑specific bone‑growth evidence.

PubMed ID: 25941810

Substantial and sustained increase in dietary calcium intake (~+360 mg/day), a fundamental input for skeletal health.

PubMed ID: 25819354

Bone‑derived calcium product (OHC) improved pain and physical QoL in osteopenic women—broadly supportive of skeletal wellbeing.

PubMed ID: 26655888

Kefir‑fermented milk plus CaCO3 resulted in measurable femoral‑neck BMD increases and favorable turnover marker changes in osteoporotic patients.

PubMed ID: 25592133

Large RCT in osteoporotic patients showed differential femoral‑neck BMD gains when adding active vitamin D vs vitamin D+calcium; calcium+vitamin D served as an important comparator informing maintenance of BMD.

PubMed ID: 26185429

Osteoporotic patients given teriparatide plus daily calcium/vitamin D had large rises in bone‑formation marker PINP while serum calcium stayed normal — supports calcium use in bone‑density management (contextual/clinical).

PubMed ID: 26009922

Calcium‑containing bone ceramic with PDGF performed similarly to autogenous bone for ridge augmentation—direct bone-healing evidence.

PubMed ID: 26439386

Randomized trial: rosuvastatin + PRF + porous hydroxyapatite produced substantially greater periodontal bone fill—strong evidence for a Ca‑phosphate graft's role in bone healing.

PubMed ID: 26478225

Participants received daily calcium; early mineral changes predicted later lumbar BMD gains with teriparatide.

PubMed ID: 26350034

Combined vitamin D + calcium (1000 mg) + protein/exercise mitigated bone loss after bariatric surgery—direct maintenance of aBMD.

PubMed ID: 24460005

High‑impact jumping increased hip BMD — demonstrates an intervention that increases bone density (not Ca supplementation but bone density outcome relevant).

PubMed ID: 26418918

CPP‑ACFP (calcium‑containing topical) produced rapid enamel remineralisation, supporting hard‑tissue health.

PubMed ID: 26174080

Calcium phosphate graft combined with enamel matrix derivative improved defect fill and attachment in periodontal defects.

PubMed ID: 26107684

Randomized trial: Ca carbonate + vitamin D3 produced modest lumbar BMD gains and combined with exercise yielded larger effects.

PubMed ID: 25782422

Vitamin D3 sustains 25OHD better than D2, supporting Ca handling and long‑term bone density maintenance.

PubMed ID: 26465394

Adolescents with low Ca intake: 25OHD thresholds associated with better BMD and lower bone‑resorption markers.

PubMed ID: 26420678

In children on dialysis, nicotinamide added to Ca‑based binders improved P, Ca×P and PTH—relevant to mineral balance and bone health.

PubMed ID: 25954758

In situ hardening calcium phosphate bone substitutes provided superior biomechanical support for dental implants—promotes bone repair.

PubMed ID: 26312576

Long‑term improvements in BMD and lower fracture incidence in postmenopausal cohort where calcium was provided as background therapy—broad relevance to skeletal health (indirect attribution).

PubMed ID: 26396095

Calcitriol (± calcium) preserved lumbar spine BMD better than calcium carbonate alone in steroid users—direct RCT evidence on bone density outcomes where calcium alone was inferior.

PubMed ID: 26701977

Lowering dialysate calcium markedly improved bone turnover and histomorphometry over 24 months—strong evidence that calcium exposure modulates bone density/quality in dialysis patients.

PubMed ID: 25636721

Population association: calcium supplement use correlated with higher 25OHD and lower PTH—favorable for bone density maintenance though observational.

PubMed ID: 26255474

Postoperative calcium+calcitriol regimen associated with BMD increases after kyphoplasty—direct evidence for maintaining/increasing BMD.

PubMed ID: 26647424

Femoral BMD increased after parathyroidectomy with normalization of calcium—strong direct evidence for maintaining/increasing bone density.

PubMed ID: 26721135

Postmenopausal BMD increases in a cohort receiving oral calcium implicate calcium as contributor to overall skeletal wellbeing (though effect isolation limited).

PubMed ID: 26214887

Elderly distal‑radius fracture patients receiving calcium carbonate exhibited shorter fracture healing time and higher bone‑formation markers when treated with adjunctive herbal therapy—study context supports calcium in healing setting.

PubMed ID: 26092649

Exercise interventions improved BMD while participants received 1200 mg/day calcium, supporting overall skeletal health in the context of adequate calcium.

PubMed ID: 26193177

Marked hip/spine BMD decreases after bariatric surgery despite recommended calcium/Vit D — important evidence about challenges maintaining bone density even with supplementation.

PubMed ID: 25636048

Parathyroidectomy normalized calcium/PTH and produced significant spine/femoral neck BMD gains—direct evidence linking calcium homeostasis to maintained/increased BMD.

PubMed ID: 26786148

Co‑supplemental Ca reduced bone turnover markers (osteocalcin, BAP, CTX), consistent with beneficial effects on bone density in short term.

PubMed ID: 27311415

Randomized dosing trial in children with nutritional rickets: 1000 mg/day Ca (and 2000 mg) healed rickets faster and increased forearm aBMD — direct evidence for supporting bone growth in children.

PubMed ID: 28030601

Quantified positive Ca mass balance per dialysis session — cumulative Ca exposure influences bone mineral balance in dialysis patients.

PubMed ID: 27422705

Percutaneous fixation using calcium sulfate cement affected wound complications and structural outcomes in calcaneal fractures—direct surgical bone‑healing context.

PubMed ID: 27552840

Robust, sustained increases in dietary calcium intake and bone‑loading activity—highly relevant to overall skeletal health determinants.

PubMed ID: 27927221

Large pediatric vitamin‑D repletion trial produced big changes in 25(OH)D with small changes in calcium/PTH—relevant to skeletal growth and mineralization.

PubMed ID: 27958765

Periodontal regeneration trial using biphasic calcium phosphate graft addresses local bone/periodontal defect healing.

PubMed ID: 26908630

Periodontal bone regeneration improved using β‑TCP scaffold with growth factor—direct evidence of calcium phosphate scaffold aiding bone repair in the jaw.

PubMed ID: 27683185

Direct human trial of calcium+vitamin D in recruits showing effects on vitamin D status and bone markers—strong overall relevance to skeletal wellbeing with supplementation.

PubMed ID: 28039060

Randomized trial: routine oral calcium after thyroidectomy greatly reduced symptomatic hypocalcemia—strong clinical evidence for supplementation improving postoperative calcium-related outcomes.

PubMed ID: 26961287

Hydroxyapatite/collagen (calcium-containing) implant produced faster/better bone regeneration vs β‑TCP—strong evidence that calcium-based materials aid bone healing.

PubMed ID: 27868294

Animal feeding study: higher dietary calcium increased serum Ca and improved bone breaking strength at an optimal dose—mechanistic support for calcium in bone strength.

PubMed ID: 27325795

Higher vitamin D dosing in very low birth weight preterms improved calcium and reduced skeletal hypomineralization — strong support for bone mineralization in infants.

PubMed ID: 26885925

Fortification of human milk (including minerals like calcium) in ELBW/VLBW infants modestly increased linear growth and changed calcium-related labs—directly relevant to infant bone growth.

PubMed ID: 27542236

Vitamin D + calcium tablets reduced a bone-resorption marker (NTx), supporting maintenance of bone mass.

PubMed ID: 27581574

Observational cohort: better calcium adequacy in infancy associated with improved linear growth to 18 months—supports role of calcium in child growth (associative).

PubMed ID: 29231409

Calcitonin improved BMD and bone markers in postmenopausal osteoporosis—supports aspects of skeletal wellbeing.

PubMed ID: 27734257

rhPTH(1–84) improved multiple biochemical indices of calcium–phosphate balance and reduced need for oral calcium/vitamin D—relevant to overall skeletal health in hypoparathyroidism.

PubMed ID: 27676398

Large cross‑sectional study in puberty showing stage‑specific calciotropic hormone changes and IGF‑1 correlation with bone mass — directly relevant to bone growth during childhood/adolescence.

PubMed ID: 26782853

Dose‑response vitamin D3 study in elderly altered iPTH/25(OH)D and serum calcium — directly relevant to maintaining bone density via calcium/VitD/PTH axis.

PubMed ID: 27880946

Vitamin D analog caused large iPTH suppression in dialysis patients, affecting bone turnover and density.

PubMed ID: 28043751

Silicate‑substituted calcium phosphate graft integrated and filled tunnels comparably to autograft — strong direct evidence for a calcium‑containing graft aiding bone healing.

PubMed ID: 26334255

Direct pediatric formula RCT: SN2‑palmitate reduced calcium‑soap losses and stool fat, improving presumed calcium availability—strong relevance to infant bone growth.

PubMed ID: 26841085

Vitamin D supplementation produced lasting increases in hip BMC in adolescent girls—supports interventions (via vitamin D–Ca axis) that help maintain bone mass/density.

PubMed ID: 26922214

Trial used calcium-containing synthetic bone grafts at extraction sites and showed preservation of alveolar ridge—strong direct evidence that calcium-containing grafts aid local bone healing and preservation.

PubMed ID: 26967465

Trial in childhood cancer survivors showed modest increases in total body BMD while participants received calcium and vitamin D—direct pediatric bone outcome with calcium as background.

PubMed ID: 27625301

MK‑7 preserved trabecular microarchitecture in postmenopausal osteopenic women who were all given calcium+vitamin D—calcium was an important background therapy associated with bone outcomes.

PubMed ID: 27683073

Sinus augmentation using calcium‑based grafts showed comparable new bone formation and better volume maintenance for one biphasic material—direct surgical bone‑healing context.

PubMed ID: 27301220

Dietary education raised calcium intake and produced higher lumbar spine and femoral neck BMD vs usual care—direct evidence linking increased calcium intake to maintained/improved BMD in patients.

PubMed ID: 27916815

Direct neonatal human study showing enteral calcium intake predicts urinary calcium and ALP and influences bone mineral markers—highly relevant to pediatric bone growth.

PubMed ID: 26879200

Long‑term odanacatib program (with supplemental calcium/vitamin D as needed) showed large, sustained BMD gains—strong evidence on bone density (though driven by drug).

PubMed ID: 26855045

Randomized comparison showed injectable calcium‑phosphate cement provided similar mechanical bone stability to autograft in high tibial osteotomy—strong direct evidence for local bone healing application.

PubMed ID: 29903135

Fortified milk containing vitamin D and milk minerals including calcium produced a short‑term measurable BMD increase—direct evidence for maintaining bone density.

PubMed ID: 27813398

Denosumab produced significant lumbar spine BMD gains in men with ADT‑related osteoporosis; all participants received 1200 mg/day calcium + vitamin D as baseline bone protection (calcium part of the bone‑density regimen).

PubMed ID: 29100829

Comparative bone graft material study reporting new bone formation and maturity — supports calcium‑containing grafts in bone healing.

PubMed ID: 28276596

Older adult RCT where all participants received 1000 mg elemental calcium — directly relevant to bone density maintenance even though vitamin D dose was the main comparison.

PubMed ID: 28330908

Randomized addition of dairy (~1500 mg Ca/d) in low‑dairy children produced a significant tibial BMC gain—direct pediatric bone growth relevance.

PubMed ID: 28522130

Post‑parathyroidectomy bone recovery data (with postoperative calcium supplementation) link mineral parameters to BMD increases—relevant to postoperative bone healing.

PubMed ID: 28975432

Fortified milk (Ca+D) suppressed bone turnover and tended to prevent femoral‑neck BMD loss over 1 year in postmenopausal women—direct support for maintaining BMD.

PubMed ID: 28248693

Pre‑exercise oral calcium attenuated exercise‑induced drop in ionized calcium and tended to blunt PTH rise—physiologic mechanism that may help preserve bone in athletes.

PubMed ID: 29246678

High‑risk feedback increased Ca+D use and slightly slowed hip BMD loss over 10 years — direct BMD effect.

PubMed ID: 28148500

Randomized trial of Ca+D showed a statistically significant reduction in fractures in the lowest BMD‑genetic‑risk quartile — direct fracture evidence.

PubMed ID: 28697860

Perioperative multimodal nutrition (including Ca) around knee surgery reduced hypocalcaemia and electrolyte problems and shortened stay—supportive for post‑op bone/electrolyte recovery.

PubMed ID: 29273827

Strong mechanistic evidence: vitamin D analogs greatly increase intestinal Ca absorption—key for maintaining bone density when Ca intake exists.

PubMed ID: 27893045

Large randomized trial showed lower hip/pelvic fracture risk with chlorthalidone (thiazide effect due to calcium retention)—provides indirect evidence that calcium handling affects fracture risk.

PubMed ID: 28583879

Maternal Ca supplementation produced sex‑specific changes in child height and bone mineral content at 8–12 years—strong direct relevance to childhood bone growth.

PubMed ID: 28552876

Randomized trial: eggshell‑derived Ca increased bone mass proxy in postmenopausal women—direct evidence for stronger bone metrics.

PubMed ID: 28703478

Randomized clinical evaluation of calcium‑containing biphasic bone substitutes found substantially greater new bone formation in extraction sockets—direct evidence for bone healing aid.

PubMed ID: 28647736

Infant vitamin D dosing study tracked serum ionized Ca and PTH — informative for infant Ca homeostasis and growth.

PubMed ID: 28351509

Prospective evidence: sustained adequate Ca intake in children produced meaningful increases in BMD and lowered osteopenia risk.

PubMed ID: 28832406

Randomized vitamin D + calcium supplementation increased 25‑OH‑D, blunted PTH rise and helped prevent bone loss—strong direct evidence for maintaining BMD.

PubMed ID: 28019683

Hip‑fracture trial used calcium/vitamin D background while showing larger BMD gains with teriparatide versus risedronate—relevant to bone density maintenance in an at‑risk population.

PubMed ID: 29178404

Rickets cohort treated with calcium + vitamin D had improved linear growth and clinical recovery—strong, direct evidence that calcium therapy preserves/grows bone in deficient children.

PubMed ID: 28604516

Infant formula study demonstrated adequate mineral (including calcium) intake and maintained serum mineral status — directly relevant to bone growth in infants.

PubMed ID: 28915914

β-TCP (calcium-phosphate) screws altered tunnel remodeling—directly relevant to bone healing/remodeling around implants.

PubMed ID: 28748492

CaP-hybridized tendon grafts reduced femoral tunnel enlargement at 1 year—strong device-level evidence that CaP enhances bone healing at graft sites.

PubMed ID: 29337906

Observed increases in spine and femoral neck BMD over 12 months; calcium/vitamin D permitted but not controlled—relevant to density maintenance.

PubMed ID: 29947083

Burosumab markedly increased fracture/pseudofracture healing in XLH patients—evidence of improved bone healing (phosphate pathway rather than supplemental Ca).

PubMed ID: 30322156

Lifestyle program in children increased dietary calcium intake—directly relevant to supporting bone growth in pediatric population.

PubMed ID: 29676968

Randomized, 2‑year trial: Ca + vitamin D–enriched milk significantly increased femoral‑neck BMD — direct evidence for maintaining/increasing BMD.

PubMed ID: 30592368

Calcium sulfate/hydroxyapatite graft reduced bone loss and preserved ridge width after extraction compared with no graft — direct aid to bone healing.

PubMed ID: 29095347

Infant amino‑acid formula delivered more calcium and led to short‑term anthropometric gains — relevant to supporting growth in infants.

PubMed ID: 30377715

Same trial also supports clinical outcomes related to post‑operative bone recovery (alternate phrasing of relevance).

PubMed ID: 30107042

Calcium citrate lowered bone formation/resorption markers more than carbonate after RYGB, suggesting preservation of bone turnover relevant to density.

PubMed ID: 30521656

Biphasic calcium phosphate graft in sinus augmentation produced comparable/new bone formation vs bovine bone—supports calcium phosphate role in bone healing.

PubMed ID: 30216697

Large dietary assessment found many infants/toddlers with low calcium intake, indicating clear relevance of calcium to pediatric bone growth needs.

PubMed ID: 29040219

Calcium + vitamin D combined with high‑impact exercise improved femoral neck T‑score vs control—supports bone density maintenance with exercise.

PubMed ID: 30594226

CaP‑treated tendon graft reduced femoral bone tunnel enlargement significantly—strong surgical evidence for calcium‑based material aiding bone healing.

PubMed ID: 30515484

Direct comparison of bone graft materials including a calcium phosphate (β-TCP) for implant sites — directly relevant to bone healing.

PubMed ID: 29903473

Infant formula enriched in sn-2 palmitate increased bone mineral content at 4 months—direct, fairly strong evidence for supporting bone growth in infants.

PubMed ID: 29557400

3-year RCT: implants with calcium-incorporated surface showed slightly less marginal bone loss vs grafted implants, directly relevant to bone maintenance around implants.

PubMed ID: 30465917

Maternal calcium supplementation RCT produced sex‑specific increases in mid‑childhood IGF‑1 and higher BMI in boys—direct developmental impact relevant to child growth.

PubMed ID: 30357438

Teriparatide bioequivalence and matched serum calcium PD—directly relevant to bone anabolic calcium biology.

PubMed ID: 30465358

Calcium hydroxide intracanal medicament resulted in high radiographic healing of periapical lesions—evidence of local bone healing facilitation.

PubMed ID: 30010081

PEMF decreased resorption (CTX) and increased formation markers (BSAP) in postmenopausal women—favors maintaining or improving bone density.

PubMed ID: 29652784

Silicated Ca‑phosphate graft used in lumbar fusion produced comparable fusion rates and clinical improvements — strong direct relevance to bone healing.

PubMed ID: 30902791

Ca+D prevented declines in vitamin D status and reduced bone turnover with modest increases in vBMD/BMC at tibia—direct evidence for maintaining bone density in young recruits under stress.

PubMed ID: 30615068

Observational: calcium‑rich dietary pattern associated with higher tibial BMC and strength in young recruits (pQCT measures).

PubMed ID: 30734085

Randomized trial: 500 mg/day calcium modestly preserved spine and femoral neck BMD in less‑active women over 2 years.

PubMed ID: 30690785

In dialysis patients, use of calcium/calcitriol adjunct prevented hypocalcemia during antiresorptive therapy and BMD improved.

PubMed ID: 30731480

Preterm infant ROM exercise increased BMD and growth — directly about bone accrual in infants (non‑calcium intervention but pediatric bone growth relevant).

PubMed ID: 31342138

1.2 g/day calcium for a year reduced total and undercarboxylated osteocalcin (bone‑turnover markers), consistent with preserved bone density.

PubMed ID: 31126121

Calcium+vitamin D or dairy preserved BMD in early postmenopausal women during weight loss.

PubMed ID: 30649176

Randomized maternal calcium (1000 mg/day) improved maternal BMD recovery at 12 months postpartum (direct bone‑strength outcome).

PubMed ID: 31375874

In adolescents, calcium+vitamin D lowered PTH and increased IGF‑1 (biomarkers supportive of growth and bone accrual), though BMD gains did not differ over 1.5 years.

PubMed ID: 31652407

Greek yogurt (a calcium‑rich food) increased bone formation markers during a training program—supports skeletal remodeling and health.

PubMed ID: 31489467

Long‑term dried beancurd increased lumbar spine BMD and decreased bone resorption marker in postmenopausal women (contains calcium).

PubMed ID: 31583921

Soy isoflavone + calcium improved BMD and biochemical markers vs control in perimenopausal women.

PubMed ID: 31213783

Matched analysis and pooled data for teriparatide showed fracture reductions; relevant to fracture risk though not a calcium supplement.

PubMed ID: 31170812

β-TCP (a calcium phosphate graft substitute) with growth factor matched autograft for ankle/hindfoot fusion — strong direct evidence for Ca-based materials aiding bone healing.

PubMed ID: 31087185

Eldecalcitol significantly increased lumbar and hip BMD in osteoporotic patients — strong evidence relevant to maintaining bone density (though not pure Ca supplement).

PubMed ID: 31101439

Large cross-sectional evidence of inadequate calcium intake across many adults — central to population skeletal wellbeing.

PubMed ID: 30843501

Vitamin D dosing in Indian schoolchildren raised 25(OH)D and reduced secondary hyperparathyroidism in a low-calcium context — directly relevant to supporting bone health and growth in children.

PubMed ID: 31740343

Bisphosphonate trial (with Ca/VitD given) showed early positive bone balance and later BMD increases — calcium used as standard adjunct, supporting bone density maintenance.

PubMed ID: 31272212

Demonstrates a practical, dose-dependent method to substantially increase dietary calcium content of rice — directly relevant to improving skeletal wellbeing at scale.

PubMed ID: 31115592

Single IV zoledronic acid reduced periprosthetic BMD loss after arthroplasty while calcium+calcitriol were provided — supports bone-healing milieu where calcium is an adjunct.

PubMed ID: 31603996

Zoledronate study (with calcium/vitamin D) produced clear BMD preservation—calcium was standard background therapy supporting density maintenance.

PubMed ID: 30976888

Study of zoledronic acid where all patients received calcium showed improved BMD and fewer recompression fractures; calcium likely part of maintenance regimen.

PubMed ID: 31058448

Zoledronate with calcium/vitamin D in elderly fracture patients reduced refracture rates—calcium contributed as baseline therapy.

PubMed ID: 30840918

Pediatric celiac study showed increases in bone formation markers; suggests impact on bone growth/turnover though calcium not the intervention.

PubMed ID: 29846719

Switching away from calcium-containing phosphate binders affected FGF‑23 and bone-turnover markers — significant for mineral/bone health in dialysis patients.

PubMed ID: 31540014

Direct assessment showing common calcium (and vitamin D) inadequacy in celiac patients — important for skeletal health.

PubMed ID: 31014177

Cinacalcet markedly altered PTH and calcium — significantly affects bone-mineral homeostasis though it is not calcium supplementation.

PubMed ID: 31321573

Same study: periapical lesion volume decreased significantly with MTA — supports bone healing (duplicate entry kept for emphasis).

PubMed ID: 31418585

Abaloparatide data directly measure BMD and show preserved efficacy across renal function — strong bone-density relevance.

PubMed ID: 31425366

Infant formula (containing calcium) maintained normal serum calcium/phosphorus over 16 weeks — supports mineral status important for infant bone growth.

PubMed ID: 31972958

Calcium‑containing synthetic bone substitute performed comparably to bovine graft and promoted new bone formation in sockets — direct aid to bone healing.

PubMed ID: 32588047

Calcium‑fortified milk reduced bone turnover markers and increased vitamin D — a strong signal for supporting bone density maintenance.

PubMed ID: 32131366

Adding collagen peptides to calcium+vitD reduced bone turnover markers in osteopenic postmenopausal women, implying beneficial bone effects.

PubMed ID: 32093625

After-school program enhanced bone-loading activity produced small improvements in calcaneal bone stiffness in children; calcium intake did not change but outcome is bone growth–relevant.

PubMed ID: 32032997

Dietary intervention improved spine/hip BMD and lowered PTH (serum calcium/ PTH changes relevant to bone density maintenance).

PubMed ID: 32495521

In very elderly osteopenic patients, regimen including calcium+active vitamin D with added alendronate increased BMD vs calcium+vitD alone; calcium was background but bone density outcome improved.

PubMed ID: 33008855

Antenatal calcium implementation data indicate achievable maternal intakes that contribute to maternal and fetal skeletal health (practical evidence).

PubMed ID: 31809394

Randomized comparison showed calcium‑containing synthetic bone graft matched autograft for tibial plateau defect healing and function—strong, direct evidence for calcium in bone healing.

PubMed ID: 31864574

Calcium phosphate bone substitute produced equivalent radiographic and functional outcomes vs autograft in ACL tunnel defects—strong support for calcium‑based materials in bone healing.

PubMed ID: 32722015

Fortified dairy with substantial calcium (plus vitamin D/K) increased bone mass and improved bone turnover markers in menopausal women — direct support for bone strength.

PubMed ID: 32676136

Calcium‑silicate pulpotomy outcomes comparable to RCT indicate calcium‑based materials help resolve pulpal pathology and facilitate repair.

PubMed ID: 32034789

Use of Ca(OH)2 intracanal medicament improved bacterial elimination that supports endodontic healing — calcium compound facilitating tissue repair.

PubMed ID: 33175326

Portland cement pulpotomy success in primary molars supports calcium‑containing materials in dental tissue healing.

PubMed ID: 30859218

Long‑term PTH suppression with etelcalcetide affects bone remodeling and density in dialysis patients (indirectly relevant).

PubMed ID: 32991652

Histomorphometry showed substantial new bone after sinus‑lift using calcium‑phosphate graft—strong evidence for aiding local bone healing.

PubMed ID: 33040465

Randomized supplement (calcium + low‑dose vitamin D) increased lumbar spine BMD over 6 months—direct evidence for bone‑strengthening effect.

PubMed ID: 32799365

Use of biphasic calcium phosphate with membrane preserved alveolar bone—supports post‑extraction bone healing and socket preservation.

PubMed ID: 32080013

Microporous biphasic calcium‑phosphate putty produced noninferior posterolateral spinal fusion vs autograft—strong direct evidence for a calcium-containing bone graft material aiding fusion/healing.

PubMed ID: 32798112

Calcium sulfate cement grafting as part of calcaneal fracture repair improved operative metrics and radiologic/functional outcomes—directly relevant to bone healing.

PubMed ID: 33027800

Medical nutrition therapy directly increased dietary calcium and vitamin D intake to support bone health; strong direct relevance.

PubMed ID: 33047971

Surgery for secondary hyperparathyroidism produced significant lumbar/femoral BMD improvements tied to calcium/PTH homeostasis.

PubMed ID: 32622071

Vitamin D + calcium co‑therapy in older adults produced BMD increases in parent trial and DLK1 changes correlated with femoral neck BMD.

PubMed ID: 32346686

Calcium (carbonate) administered with vitamin D in zoledronate recipients augmented bone turnover marker suppression and BMD gains—direct evidence for maintaining/increasing bone density.

PubMed ID: 33138121

Dietary modelling showed that adding a milk serving (high in calcium) substantially reduces calcium inadequacy in Filipino children—directly relevant to bone growth/nutrition.

PubMed ID: 32723294

Marked long‑term reductions in PTH and phosphorus with HDF indicate improved mineral homeostasis relevant to overall skeletal health in dialysis patients.

PubMed ID: 32796301

Biosilicate orbital implant used for socket reconstruction with low complication rates — direct application of mineral/bioactive material to aid hard‑tissue healing.

PubMed ID: 34670754

Cluster RCT increasing dietary calcium/protein significantly reduced all fractures (HR 0.67) and hip fractures (HR 0.54)—strong direct evidence.

PubMed ID: 34201328

MTA plus bone graft achieved best radiographic defect fill in combined endo‑periodontal lesions—supports bone healing with calcium-containing materials.

PubMed ID: 34980546

Both trial arms received calcium+vitD; adding collagen peptides yielded improved tibial/spine BMD vs Ca+D alone—calcium was part of regimen.

PubMed ID: 33561253

Calcium+vitD in pregnant adolescents reduced early postpartum femoral neck bone loss (short‑term benefit).

PubMed ID: 33530298

Fortified protein/micronutrient drink (including calcium) decreased bone resorption markers and improved markers of bone formation.

PubMed ID: 34125899

Trial in adolescents (perinatally acquired HIV) showed higher-dose vitamin D + calcium produced greater spine BMD z-score gains—direct evidence for supporting bone growth.

PubMed ID: 34861430

Daily Ca+D prevented exercise-induced increases in bone resorption markers in recruits (biochemical protection of bone), supportive of bone strength maintenance.

PubMed ID: 33722312

Parental intervention led to sustained increases in children's dietary calcium intake over 1 year—directly relevant to supporting bone growth in kids.

PubMed ID: 34657018

Calcium-containing materials used in pulpotomy promoted root development and high clinical success—relevant to localized dental/bony healing.

PubMed ID: 32939557

Dietary shift to plant-based protein increased bone turnover markers likely due to lower calcium intake—important to overall skeletal health considerations.

PubMed ID: 33975993

Marked lumbar spine BMD gains in denosumab trial (with calcium given to all)—supports maintenance/improvement of bone density.

PubMed ID: 33904027

Potassium citrate lowered urinary calcium and raised citrate in hypercalciuric stone formers—clinically relevant to calcium stone prevention and skeletal/kidney health.

PubMed ID: 34269239

In-situ hardening biphasic calcium phosphate graft (calcium‑containing) produced equivalent sinus height gain and implant stability to xenograft—direct evidence for calcium-based grafts aiding bone augmentation/healing.

PubMed ID: 33731168

Post‑knee replacement monitoring-guided osteoporosis therapy included calcium and produced large BMD gains—calcium was part of effective regimen (supportive role).

PubMed ID: 33951328

Elderly osteoporotic RCT where calcium (800 mg/day) was provided to all participants; active vitamin D + calcium groups showed clear lumbar BMD improvements—strong evidence calcium is part of bone-density–supportive regimens.

PubMed ID: 33724542

Large odanacatib osteoporosis trial (all on 1200 mg/day calcium) showed reductions in hip/femur fractures — background calcium part of regimen, supporting fracture prevention context (indirect attribution).

PubMed ID: 34154321

Transplant recipients received calcium (500 mg/day) plus vitamin D; neridronate improved spine BMD while calcium formed baseline therapy—relevant context for maintaining BMD.

PubMed ID: 34302325

Vitamin D‑fortified milk in schoolchildren reduced secondary hyperparathyroidism (a driver of bone turnover) — directly relevant to calcium/VitD axis and bone health.

PubMed ID: 34237973

One‑stage implantation of vancomycin‑loaded calcium phosphate cement produced high cure rates and promoted bone healing in chronic osteomyelitis — direct bone‑healing benefit from a calcium phosphate material.

PubMed ID: 33606045

Alendronate discontinuation caused measurable declines in BMD within 12 months—directly relevant to maintenance strategies (including Ca/Vit‑D) to preserve BMD.

PubMed ID: 33998210

CPC loaded with rhBMP‑2 plus antibiotic shortened time to external‑fixator removal and to full weight‑bearing vs CPC alone—strong implant evidence for improved bone healing.

PubMed ID: 34040361

Resorbable calcium‑salt fillers in vertebral stentoplasty produced pain relief and promoted osteogenesis over 3 years—direct clinical bone‑healing outcomes.

PubMed ID: 34109778

Single high‑dose vitamin D (stoss) produced the largest 25(OH)D rise and decreased PTH in children—important for growth‑related calcium homeostasis.

PubMed ID: 34347093

TransCon PTH restores physiologic PTH effects and stabilizes calcium, supporting overall skeletal health in hypoparathyroidism.

PubMed ID: 36271471

Phase‑3 TransCon PTH produced durable normalization of calcium and urine calcium and reduced conventional therapy—supports bone density maintenance in affected patients.

PubMed ID: 35466448

Romosozumab markedly increases BMD across CKD stages—direct, high‑relevance to maintaining bone density.

PubMed ID: 35739544

Reflex locomotion physiotherapy in preterm infants increased osteocalcin (bone‑formation marker) and height—supports interventions that increase bone formation (indirect to calcium).

PubMed ID: 34617558

Infant formula with milk‑derived oligosaccharides reduced fecal calcium loss and shifted microbiota—directly implies better calcium availability for infant bone growth.

PubMed ID: 35505326

Vitamin D ± calcium trial showed PTH lowering and higher urinary Ca/Cr with combined therapy in adherent participants—biochemical support for calcium's role in bone metabolism.

PubMed ID: 34751787

Randomized crossover: single 1,000 mg calcium (milk or CaCO3) acutely suppressed CTX‑1 (bone resorption) ~44%—direct evidence that calcium intake reduces bone turnover.

PubMed ID: 35191065

Guided bone regeneration RCT using calcium‑phosphate biomaterials demonstrated effective hard‑tissue dimensions at 6 months—direct evidence for calcium‑containing materials aiding bone repair.

PubMed ID: 36330670

Soft‑block calcium‑phosphate grafts increased ridge contour in early healing—directly relevant to bone healing around implant sites.

PubMed ID: 35015862

Randomized increase in dairy (major calcium source) produced clinically meaningful hip BMD gains in adolescent girls—direct evidence for stronger bones.

PubMed ID: 35759368

High‑dairy pregnancy intervention maintained bone formation and limited resorption — supports maternal skeletal wellbeing.

PubMed ID: 36272766

Moldable calcium phosphate putty used in sternal closure improved pain, function and respiratory recovery—strong evidence for aiding bone healing.

PubMed ID: 35353097

Calcium phosphosilicate bone substitute preserved socket dimensions and yielded implantable-quality bone at 6 months—direct support for bone healing/regeneration.

PubMed ID: 34936992

Five-year personalized program reduced fragility fractures in elderly women—direct evidence of lower fracture risk (multifactorial intervention).

PubMed ID: 35446950

Trial comparing graft materials found calcium‑based alloplasts produced vital new bone for implant sites—direct evidence for Ca‑based grafts aiding local bone healing.

PubMed ID: 35973626

Vancomycin‑impregnated calcium sulfate beads dramatically reduced early periprosthetic joint infection and shortened hospital stay—improves conditions for bone/implant healing.

PubMed ID: 35411924

Improved Ca absorption from synbiotic yogurt increases available mineral for broad skeletal health (mechanistic evidence).

PubMed ID: 35844452

Calcium-alone therapy raised BMD in diabetic osteoporosis — clear relevance to skeletal wellbeing.

PubMed ID: 35799339

Calcium hydroxide pulp-capping showed high dental success — local calcium material benefit to tooth structure.

PubMed ID: 35869721

Large RCT: calcium-enriched pulp therapy materials reduced periapical lesions — strong local benefit to dental/skeletal tissues.

PubMed ID: 34679162

Topical calcium-phosphate varnish offered modest protection against enamel lesions — supports dental skeletal tissue health.

PubMed ID: 36249246

Weekly SMS increased infants' dietary calcium intake at 4–6 months — directly relevant to bone growth in early life.

PubMed ID: 36336861

Elderly vitamin D dosing changed metabolites without hypercalcemia and is directly relevant to calcium/vitamin D regulation that maintains bone density.

PubMed ID: 36014837

Vitamin D3 repletion reduced PTH (favorable for bone conservation) — supports bone‑density maintenance indirectly.

PubMed ID: 34636899

Long‑term burosumab in XLH children produced substantial improvements in rickets and growth — directly relevant to pediatric bone growth (phosphate pathway rather than calcium supplementation).

PubMed ID: 36779614

Aragonite (calcium‑based) osteochondral implant improved knee pain/function and reduced failure vs microfracture/debridement over two years — direct clinical evidence for a calcium scaffold aiding osteochondral repair/healing.

PubMed ID: 36808216

Randomized calcium (600 mg) in preadolescents increased bone mineral content/density at 6 months — direct evidence supporting bone growth in children.

PubMed ID: 37111231

Cluster‑RCT in 4–6‑year‑olds: fortified milk (~720 mg Ca/day) significantly increased forearm BMD/BMC — direct child bone growth evidence.

PubMed ID: 36944142

Osteoporotic women on Ca+vitD (background) had greater BMD gain with adjunct therapy — supports bone benefit of Ca+vitD regimen.

PubMed ID: 37389558

Direct RCT evidence that boosting dietary calcium/protein reduced hip and nonvertebral fractures in aged‑care residents.

PubMed ID: 37909613

Dietary calcium correction in hypoparathyroid disease corrected serum Ca in most pts — key to skeletal health.

PubMed ID: 36825719

β‑TCP+HA bone graft with PRF produced greater clinical attachment gains and radiographic defect fill — strong direct evidence for calcium‑based grafts aiding bone healing.

PubMed ID: 37861611

Multi‑nutrient supplement including calcium produced within‑group BMD improvements in edentulous women.

PubMed ID: 37314107

RCT of biphasic calcium phosphate graft (HA/β‑TCP) showed superior maintenance of augmented bone thickness — strong direct evidence for calcium‑based materials preserving bone.

PubMed ID: 36982613

Injectable biphasic calcium phosphate produced comparable new bone formation to bovine xenograft after ridge augmentation—direct material evidence for bone healing.

PubMed ID: 37278972

Anti‑RANKL (GB223) strongly suppressed bone resorption markers and affected serum calcium/phosphate/PTH—mechanistically relevant to maintaining BMD.

PubMed ID: 37843657

rhBMP‑2 incorporated calcium phosphate material accelerated degradation and increased new bone in socket preservation—strong evidence for bone healing with Ca‑based graft.

PubMed ID: 37120127

Dietary intervention rapidly lowered PTH/FGF23 and raised serum calcium in dialysis patients — changes that support bone‑mineral balance and BMD maintenance.

PubMed ID: 37167726

Two active treatments were given with calcium + vitamin D3; both arms showed BMD increases — calcium was part of the bone‑density regimen.

PubMed ID: 37814913

Cinacalcet + paricalcitol altered phosphate and calcium in hemodialysis patients, affecting bone‑mineral homeostasis relevant to BMD maintenance in this population.

PubMed ID: 37299491

Randomized trial in picky young children: fortified oral supplements raised daily calcium to ≥EAR and improved nutrient adequacy—directly relevant to pediatric bone growth nutrition.

PubMed ID: 36833994

Large pediatric study linking vitamin D deficiency to increased fracture risk and showing benefit of vitamin D+calcium supplementation on callus formation—strong pediatric bone growth/healing relevance.

PubMed ID: 38198649

Denosumab in children with OI raised aBMD and improved vertebral shape — supports bone accrual/growth in a pediatric bone disorder (pharmacologic intervention).

PubMed ID: 38325238

Randomized calcium (milk or pill) + vitamin D intervention in children with T1DM produced substantial improvements in TBLH BMC, LS BMAD Z‑score and cortical thickness — direct evidence for supporting bone growth.

PubMed ID: 38368307

Exercise or bisphosphonate improved hip structural strength estimates—relevant to overall skeletal health.

PubMed ID: 39043915

Large RCT in preschool children: daily milk (dietary calcium source) produced clear, clinically meaningful forearm BMD/BMC increases over 12 months.

PubMed ID: 38881258

Biphasic calcium phosphate ceramic produced superior posterolateral spinal fusion rates vs autograft at 1 year—strong direct evidence for calcium‑based material aiding bone healing.

PubMed ID: 39603923

Calcium citrate produced greater serum Ca exposure and PTH suppression versus carbonate—beneficial for Ca balance and bone maintenance (mechanistic evidence).

PubMed ID: 39138889

Pediatric vitamin D repletion study co‑administered 500 mg/day Ca and showed improvements in 25(OH)D, serum calcium and PTH — directly relevant to supporting bone mineralization in children.

PubMed ID: 39475095

Regenerative endodontics using calcium silicate cements led to periapical healing in most mature necrotic teeth — local bone/tooth healing associated with Ca materials.

PubMed ID: 39478364

BMP‑2–functionalized calcium‑phosphate graft substantially accelerated early socket bone formation and reduced need for later augmentation—strong direct evidence for Ca‑based grafts aiding bone healing.

PubMed ID: 38216920

Direct neonatal randomized trial: continuous calcium infusion produced lower ALP and lower incidence of biochemical metabolic bone disease — strong evidence for preserving bone status.

PubMed ID: 39477477

Post‑vertebroplasty RCT: background calcium carbonate + vitamin D with added calcitonin produced better pain and bone‑metabolism marker improvements — supportive evidence for aided bone‑recovery after vertebral fracture.

PubMed ID: 39533934

Tricalcium‑phosphate (a calcium phosphate) bone graft with PRP reduced early crestal bone loss around implants — direct evidence that calcium‑phosphate grafting supports local bone healing.

PubMed ID: 38937331

Adolescent study linked combined exercise/diet to BMC/BMD gains and emphasized low dietary calcium intake limiting bone accrual — directly relevant to bone strength and calcium nutrition.

PubMed ID: 38834143

Platelet concentrate activated with calcium chloride produced better radiographic socket bone formation than standard PRF — strong local bone‑healing benefit from calcium activation.

PubMed ID: 38357942

Osteoporosis trial arms included calcium + active vitamin D as baseline therapy and reported improved BMD and pain relief — calcium contributed to overall skeletal wellbeing in context of multimodal therapy.

PubMed ID: 39587799

Dairy-protein breakfast increased calcium intake by ~386 mg/day and produced a small but significant increase in bone mineral content (BMC).

PubMed ID: 40259289

Combined exercise + vitamin D with ensured calcium intake improved BMD and bone markers—supports overall skeletal wellbeing (calcium part of regimen).

PubMed ID: 40042722

Background calcium+calcitriol therapy was part of an effective regimen that improved BMD and bone metabolism markers.

PubMed ID: 40214048

Surgical management lowered vertebral fracture incidence; calcium/vitamin D used as supportive therapy — clinically meaningful skeletal outcome.

PubMed ID: 39804018

Oral calcium (1000 mg) before strenuous exercise prevented drops in ionized Ca, suppressed PTH increase and reduced bone resorption marker βCTX — direct mechanistic evidence supporting preservation of bone mineral over repeated exposures.

PubMed ID: 39991811

Multinutrient protein drink with jump training reduced BMD loss in children—nutritional intervention with positive bone outcomes (indirect to calcium supplementation).

PubMed ID: 39861392

Calcium maltobionate randomized trial showed maintained/improved calcaneal YAM and facial bone density and reduced bone resorption markers in adults.

PubMed ID: 40089924

Caltrate D plus exercise produced greater increases in lumbar and femoral neck BMD than Caltrate D alone in postmenopausal women.

PubMed ID: 39985668

Significant BMD gains in an osteoporosis RCT where all subjects received calcium supplementation — directly relevant to maintaining bone density (though calcium's isolated effect not proven here).

PubMed ID: 40806109

Children given vitamin D + calcium (with omega‑3) had increased 25OHD, decreased PTH and lower bone resorption marker — supports bone accrual in children (small study, combined agents).

PubMed ID: 40388262

rhBMP‑2 on biphasic calcium phosphate dramatically accelerated graft replacement by new bone versus carrier alone — direct, large effect on bone healing/regeneration.

PubMed ID: 41462207

Infant formula with high sn‑2 palmitate significantly reduced fecal calcium excretion — directly indicates improved calcium absorption important for infant bone growth.

PubMed ID: 40021606

Both vitamin D dosing regimens safely corrected deficiency in children with IBD, supporting calcium metabolism needed for pediatric bone growth.

PubMed ID: 40155539

Intracanal calcium‑based dressings reduced inflammatory and bone‑resorption mediators in periapical lesions — supports local bone healing processes.

PubMed ID: 40116954

β‑TCP coated bovine graft preserved alveolar ridge width/height after extraction — direct bone healing/replacement evidence.

PubMed ID: 41387706

Toddler formula including Ca improved tibia bone‑quality index and handgrip over 6 months — direct pediatric bone growth support (multi‑component formula).

PubMed ID: 39812183

Eldecalcitol + risedronate produced significant increases in spine and hip BMD over 24 months.

PubMed ID: 40080289

Aragonite (CaCO3) scaffold improved osteochondral lesion repair and MRI defect fill — strong local bone/cartilage repair evidence.

PubMed ID: 40425867

Teriparatide→alendronate sequence halved morphometric vertebral fracture incidence in frail older women — direct fracture risk reduction evidence.

PubMed ID: 40203301

Behavioral intervention increased calcium supplement use and prevented serum calcium deterioration in subset.

PubMed ID: 40691703

Bioceramic apical plug produced faster radiographic healing and greater bone radiodensity than MTA.

PubMed ID: 40466630

Extended‑release calcifediol normalized vitamin D and stabilized PTH—key regulators of bone density.

PubMed ID: 39856505

Use of calcium phosphate cement with growth factors in periodontal defects produced superior clinical attachment and radiographic hard-tissue fill at 1 year—direct evidence of Ca-based material aiding bone repair.

PubMed ID: 19672742

Human RCT in postmenopausal women where ipriflavone added to a regimen that included a compound calcium chelate produced greater BMD improvements versus calcium alone — calcium was present in all groups so effect is confounded but the trial supports that calcium-containing regimens are associated with bone benefit.

PubMed ID: 8028755

Addition of an agent to improve calcium uptake increased BMD and lowered PTH/resorption markers in elderly osteoporotic patients — strong evidence for maintaining density.

PubMed ID: 8592955

Direct observational evidence from 523 older men showed no association between dietary calcium intake and proximal femur BMD—high relevance to the benefit (negative finding).

PubMed ID: 9517598

Found greater BMD increases with one inhaled steroid — clear, directly relevant bone density data (though not a calcium supplement trial).

PubMed ID: 10357743

Randomized trial of added calcium/phosphate in infant formula — directly relevant to mineral supply during critical bone/tooth development in infants.

PubMed ID: 10362172

Hormone therapy produced spine/hip BMD increases over 2 years — directly relevant to maintaining bone density (not calcium supplementation).

PubMed ID: 11444081

Dietary calcium intake (low) associated with faster femoral neck bone loss → strong evidence linking calcium status to bone density maintenance.

PubMed ID: 12510800

Men treated with teriparatide (all received calcium+vitamin D) showed notable gains in spine and femoral neck BMD—supports role of calcium in maintaining bone density (co‑treatment, indirect).

PubMed ID: 16268104

Animal layer study showed improved tibia ash and bone mineralization with enhanced mineral availability.

PubMed ID: 17656221

Observed association between calcium/vitamin D supplementation and higher BMD in men on ADT—directly relevant to maintaining BMD.

PubMed ID: 19321589

Pediatric study showing meal-based calcium increased fractional absorption from 27.8% to 61.3%—directly supports dietary strategies for bone growth in children.

PubMed ID: 27281879

Calcium‑containing composite cage used in lumbar fusion produced similar radiographic/clinical outcomes and 90% fusion rate vs PEEK — direct application of Ca‑containing biomaterial to bone healing.

PubMed ID: 34039329

Large cross‑sectional screening dataset: reported calcium tablet use associated with substantially lower odds of low BMD—strong observational support for maintaining bone density.

PubMed ID: 17896582

AKG‑Ca produced a robust 37% reduction in CTX (bone resorption marker) over 6 months in osteopenic postmenopausal women.

PubMed ID: 11528489

Neonatal study measured intestinal calcium absorption % — directly informative for infant bone mineralization.

PubMed ID: 23444750

Randomized trial in osteopenic postmenopausal women where calcium + vitamin D was baseline therapy; the trial showed a small but statistically significant improvement in heel estimated BMD with added antioxidants — calcium was part of the effective regimen, giving indirect but relevant evidence for bone density maintenance.

PubMed ID: 15657588

Clear improvements in BMD and bone markers after correcting hyperparathyroidism—strong evidence for skeletal benefits tied to calcium physiology.

PubMed ID: 18500152

Strong caries prevention in children using an arginine-bicarbonate-calcium carbonate product—oral/dental skeletal element of general skeletal wellbeing.

PubMed ID: 29151102

Decreases in bone turnover markers with Ca+vitamin D are consistent with maintenance of bone density in postmenopausal women, though direct BMD/fracture data and the confounding vitamin D co‑supplementation weaken certainty.

PubMed ID: 20605872

Randomized feeding trials in postmenopausal women showed measurable decreases in BMD under certain diets—directly informative about bone density determinants.

PubMed ID: 9200359

Large pediatric cohort identified an increased risk that girls consumed <2/3 RDA of calcium—directly relevant to bone growth in children.

PubMed ID: 9586828

Large RCT administering calcium carbonate (1.6 g/d) produced marked changes in fecal calcium (human supplementation data relevant to bone mineral handling).

PubMed ID: 12396159

Nutrition program increased dairy/calcium intake in elders, a practical approach to support BMD maintenance.

PubMed ID: 15325679

Demonstrated that a low-fat vegan diet reduced food-sourced calcium in postmenopausal women; highlights risk to bone density if not supplemented.

PubMed ID: 24139824

School‑age children received 700 mg/day calcium plus vitamin D in fortified orange juice — direct intervention in children supplying calcium relevant to bone growth; measured outcome was vitamin D but calcium dose is clinically meaningful.

PubMed ID: 16946216

Adolescent maternal dairy-calcium supplementation produced heavier, more bone-mineralized newborns — direct evidence of enhanced neonatal bone accrual.

PubMed ID: 24267005

Large randomized school-based trial: fortified products and supplements raised vitamin D in children and affected bone biomarkers — strong support for bone growth in kids.

PubMed ID: 15658548

Demonstrated increases in lumbar spine and smaller hip BMD improvements vs expected decline—strongest direct evidence in the dataset for maintaining/improving BMD.

PubMed ID: 31338563

13-week intervention with vitamin D + Ca + leucine produced a small (~2%) improvement in total-body BMD — direct evidence supporting bone strength/density.

PubMed ID: 38032288

Combined exercise and nutrition program that included Ca improved muscle and inflammatory markers relevant to skeletal wellbeing.

PubMed ID: 7962303

Postmenopausal cohort: calcium treatment predicted less axial bone loss (direct BMD outcome).

PubMed ID: 2387950

Direct RCT in elderly: calcium + vitamin D increased 25‑OH D and was safe—broadly supportive of skeletal wellbeing in older adults.

PubMed ID: 2203964

Large RCT: calcium supplementation reduced bone loss at multiple sites in postmenopausal women with low baseline intake (direct BMD benefit).

PubMed ID: 2268740

Direct randomized evidence of increased radial BMD in elderly osteoporotic women after calcium supplementation.

PubMed ID: 2203847

1000 mg/day calcium in older adults significantly lowered PTH (reduces bone resorption) and increased urinary Ca—strong physiologic support for maintaining bone density.

PubMed ID: 2221645

Calcitriol increased spine BMD over 2 years in postmenopausal women (supports interventions that enhance/maintain bone density tied to Ca metabolism).

PubMed ID: 2126198

5 years of continuous HRT kept bone mass stable versus expected loss—relevant to bone density maintenance (indirectly related to Ca physiology).

PubMed ID: 2294135

Increased dairy/calcium intake attenuated vertebral BMD loss over 3 years—strong direct evidence for maintaining bone density.

PubMed ID: 2225706

Comparative steroid regimen study showed differential bone loss, informing bone density effects under different therapies.

PubMed ID: 2153040

Salmon calcitonin PK study measured ionized calcium (no change) and cAMP—relevant to bone metabolism regulation.

PubMed ID: 2195929

Calcium (1 g/day) given in trial; BMD increased with added calcitonin and declined with calcium alone—direct BMD data.

PubMed ID: 1874931

Direct RCT showing Ca supplementation (1000–2000 mg/day) reduced lumbar bone loss and lowered bone turnover markers—strong support for maintaining bone density.

PubMed ID: 1922205

Calcium supplementation added to exercise markedly slowed forearm bone loss versus exercise alone.

PubMed ID: 1935862

All three calcium preparations produced transient decreases in a resorption marker (short-term signal relevant to density).

PubMed ID: 1991950

Sustained suppression of PTH with 1.2 g/day calcium in elderly supports reduced bone turnover and maintenance of density.

PubMed ID: 2021138

Higher dietary calcium produced a clear femoral‑neck BMD increase (direct evidence for maintaining/increasing BMD).

PubMed ID: 1649288

Trial in very low birth weight infants showing optimal Ca:P TPN ratio improved calcium and phosphorus retention — direct relevance to bone mineral accrual in infants.

PubMed ID: 1883119

Postmenopausal RCT where baseline calcium supplementation was provided to all; vitamin D addition preserved spine BMD during winter — indicates calcium status is important for BMD maintenance.

PubMed ID: 2023034

Collagraft (calcium phosphate ceramics + collagen) performed comparably to autogenous cancellous bone for acute long-bone grafting at 6–12 months — strong direct evidence for bone healing application of calcium-containing material.

PubMed ID: 1773136

Direct randomized trial in postmenopausal osteoporosis: calcium alone did not prevent spinal BMD loss—highly relevant to maintenance questions (negative/limited effect).

PubMed ID: 1910254

Population evidence of widespread suboptimal intake supports the need for interventions for skeletal health.

PubMed ID: 1823383

Calcitriol significantly increased serum/urinary calcium and decreased PTH—directly relevant to skeletal wellbeing.

PubMed ID: 1858733

Neonatal formula vs breast results showed lower ionized Ca and higher PTH in formula‑fed neonates — directly relevant to early bone mineral status/growth.

PubMed ID: 1810080

Pamidronate significantly lowered bone resorption markers and urinary Ca — strong impact on skeletal metabolism (drug intervention).

PubMed ID: 1825515

CL2MDP (bisphosphonate) reduced urinary Ca and hydroxyproline, improving bone symptom control — relevant to skeletal wellbeing.

PubMed ID: 1611221

Randomized elderly trial: 800 mg/day calcium raised hip BMD at Ward's triangle and intertrochanteric area and lowered PTH.

PubMed ID: 1536215

Higher calcium intake was independently associated with better spinal BMD response in a hormone‑therapy trial.

PubMed ID: 1393035

Elderly osteoporosis trial: calcium (500 mg) used in all groups; calcium-alone arm had a modest +1% spine BMC — direct supplementation context supporting bone density maintenance (modest effect).

PubMed ID: 1415066

Infant feeding trial with mineral‑optimized formula (includes calcium) showed higher bone mineral content in infants on the formula vs human milk, supporting calcium's role in early bone growth.

PubMed ID: 1422320

Strongest direct evidence in the set linking Ca (given to all patients) with improved BMD and favorable bone‑turnover markers in postmenopausal osteoporosis (though co‑treatment confounds attribution).

PubMed ID: 1552999

Oral CaCO3 used clinically in renal patients with measurable effects on PTH and bone‑metabolism markers — relevant to skeletal health in this population.

PubMed ID: 1560192

Demonstrates hormonal regulation (calcitonin) in response to Ca — mechanistic support for maintaining skeletal health in women.

PubMed ID: 1435827

Direct infant feeding study showing high intestinal calcium absorption and preserved bone mineralization—strong pediatric relevance.

PubMed ID: 1612530

Randomized trial used daily 500 mg calcium in all arms; calcitonin+calcium preserved lumbar BMD while calcium‑only lost BMD—direct bone density context with calcium as background therapy.

PubMed ID: 8421475

Direct RCT evidence that 1000 mg/day calcium markedly slowed BMD loss over 2 years—strong support for maintaining bone density.

PubMed ID: 8340983

Adolescent RCT showed significant increases in lumbar spine and total body BMD with calcium citrate malate supplementation — clear evidence for maintaining/increasing bone density in this group.

PubMed ID: 8410382

Premature infants given calcium+phosphate after discharge had far fewer hypophosphatemia events—direct evidence that supplementation supports infant bone mineralization/growth.

PubMed ID: 8453193

Calcium 600 mg/day given to all; while calcium alone did not prevent early postmenopausal spine BMD loss, the trial is directly relevant to skeletal outcomes.

PubMed ID: 8340736

Calcium 1000 mg/day as background therapy; vertebral BMC increased when another agent added — shows calcium's role as baseline for BMC.

PubMed ID: 8334031

Bisphosphonate ± calcitriol increased lumbar BMD; interventions that alter Ca handling (calcitriol) affect bone density.

PubMed ID: 8299406

EDTA chelation caused hypocalcemia, big PTH rise and markers of bone breakdown — very relevant to skeletal wellbeing via Ca homeostasis.

PubMed ID: 8292845

Post‑hip fracture calcitonin reduced biochemical markers of bone breakdown during immobilization — supports bone healing/recovery processes.

PubMed ID: 8298198

Alendronate lowered turnover and produced modest lumbar spine BMD gains — strong effect on maintaining/increasing BMD (drug).

PubMed ID: 8304047

Nasal calcitonin attenuated immobilization‑induced resorption marker rises—relevant to preserving bone in disuse states.

PubMed ID: 8355124

High‑calcium formula produced clear, clinically relevant bone mineral benefits in preterm infants—strong overall skeletal evidence.

PubMed ID: 8164614

Treatment that lowered urinary Ca and increased bone mass demonstrates a clinically meaningful skeletal effect.

PubMed ID: 8323358

Preterm infants given higher‑calcium/phosphorus formula had substantially higher bone mineral content at 3 and 9 months.

PubMed ID: 8183178

Combined calcitonin plus oral calcium increased cortical bone mass and reduced turnover markers in early postmenopausal women; calcium contributed to regimen though effect of calcium alone is not isolated.

PubMed ID: 7619105

Randomized double‑blind trial: 300 mg/day Ca in children with low intake increased distal radial BMC and BMC/bone width over 18 months—direct evidence for supporting bone growth.

PubMed ID: 8256988

1700 mg/day Ca slowed total body and femoral neck bone loss vs placebo—strong RCT evidence for maintaining BMD in early postmenopause.

PubMed ID: 8027856

Clear randomized evidence that calcium (with trace minerals) increased lumbar spine BMD—strong support for skeletal wellbeing.

PubMed ID: 8135445

Study found fewer new vertebral fractures; however sodium fluoride (primary agent) produced the fracture reduction while calcium citrate was background therapy—some indirect relevance.

PubMed ID: 7968645

Study with background 500 mg/day calcium: treated women gained BMD while untreated lost—direct BMD outcome with Ca present.

PubMed ID: 8154311

Trial showed 500 mg/day calcium alone did not prevent spine loss but addition of therapy preserved BMD—important context for Ca's role.

PubMed ID: 7979855

Tamoxifen maintained spine BMD over 5 years—relevant to bone maintenance (study not a Ca supplement trial but bone outcome reported).

PubMed ID: 7812072

RCT demonstrating prevention of femoral bone loss and fewer vertebral fractures with Ca supplements—direct strong-bone evidence.

PubMed ID: 7942164

Long-term Ca supplementation preserved lumbar BMD and cortical thickness—broad benefit to skeletal health.

PubMed ID: 7989461

Pamidronate RCT produced substantial spine and hip BMD increases in postmenopausal osteoporosis (strong evidence for maintaining/increasing BMD; drug therapy).

PubMed ID: 7953984

Higher‑dose intranasal calcitonin modestly reduced turnover and helped prevent early postmenopausal bone loss (drug).

PubMed ID: 8040762

Detailed observational data on bone mineral accrual during puberty and role of growth/activity; dietary calcium measured — directly relevant to lifetime skeletal wellbeing.

PubMed ID: 7977523

Higher dietary calcium predicted more complete BMD recovery after nafarelin therapy—one of the clearest dataset links between calcium intake and preservation/recovery of BMD.

PubMed ID: 8049820

Treated group (calcium + vitamin D + EHDP) had no new vertebral fractures vs 4 in control during the study—evidence of fracture risk reduction within this combined treatment context.

PubMed ID: 8157728

Patients received 0.5 g/day calcium within a regimen that prevented bone loss compared with placebo—evidence of maintained bone density though multiple drugs were used.

PubMed ID: 8062152

Addition of 300 mg calcium/day with 1α‑hydroxyvitamin D3 produced a measurable lumbar BMD increase vs placebo and fewer vertebral fractures; calcium was co‑administered but the trial shows bone density benefit in the regimen.

PubMed ID: 7709944

RCT reported fewer symptomatic fractures in Ca group vs placebo over 4 years—direct evidence.

PubMed ID: 7547823

Randomized trial in 7‑yr‑olds: Ca supplement increased lumbar‑spine BMC and area over 18 months—direct evidence.

PubMed ID: 7572323

VDR genotype‑dependent bone loss varied with Ca intake—evidence that Ca intake modifies bone loss rates.

PubMed ID: 7606425

Ca+D raised 25(OH)D and lowered PTH in elderly—biomarker profile consistent with reduced bone resorption and maintained density.

PubMed ID: 7484282

2‑yr RCT: 1 g/day Ca reduced bone loss at hip and tibia (tablet/milk) — strong support for density maintenance.

PubMed ID: 7572702

Higher Ca intake associated with prevention of hip bone loss—direct evidence for maintaining BMD.

PubMed ID: 7639438

Combined therapy with continuous calcium produced meaningful increases in bone mass and fewer fractures—calcium part of effective skeletal regimen.

PubMed ID: 7699532

Randomized dairy‑calcium supplementation in pubertal girls produced substantial increases in spine and total‑body bone mineral accrual over 1 year—direct evidence for supporting bone growth in children/teens.

PubMed ID: 7852497

Demonstrates key factors (vitamin D status, transit time) affecting calcium absorption and thus overall skeletal calcium supply.

PubMed ID: 7565455

Direct RCT evidence in very elderly women that a specific calcium supplement maintained/increased spine and radial BMD vs placebo.

PubMed ID: 7671159

Antiresorptives plus routine calcium (1,000 mg/day) were associated with vertebral BMD increases—calcium provided as supportive therapy.

PubMed ID: 8569136

Supplementing preterm formula with calcium and phosphorus significantly improved mineral retention in VLBW/SGA infants—direct, high‑relevance evidence for bone growth.

PubMed ID: 7890057

Calcium carbonate given in context of endometriosis treatment appeared to help prevent bone loss—supportive but confounded by co‑therapies.

PubMed ID: 7714086

GnRH agonist caused negative calcium balance and lumbar spine bone loss — evidence that altered calcium handling leads to BMD decline (indirect support for maintaining calcium balance).

PubMed ID: 7738683

Premenopausal women on calcium supplements: diet, composition and exercise predicted site‑specific BMD slopes — supports contribution of calcium-inclusive regimens to BMD maintenance.

PubMed ID: 7625347

Direct study in very low birth weight infants: high calcium intake supported adequate calcium retention for intrauterine accretion when phosphorus was sufficient — highly relevant to skeletal growth.

PubMed ID: 7703621

Direct randomized comparison in osteoporotic postmenopausal women showing differences in trabecular bone loss vs calcium carbonate — high relevance to maintaining BMD.

PubMed ID: 8775626

Parathyroidectomy effects on BMC illustrate clinical interventions that influence skeletal recovery and long-term bone status tied to calcium physiology.

PubMed ID: 7599447

Fluoride+calcium increased lumbar BMD vs calcium alone; calcium contributed to skeletal outcomes though combined therapy drove the large effect.

PubMed ID: 8729258

Direct dietary trial showing much lower calcium intake/absorption from an experimental milk substitute—strongly relevant to bone calcium supply.

PubMed ID: 7649343

Large survey of ~35,000 Italian children showing many have calcium intake below recommendations—directly relevant to pediatric bone growth risk.

PubMed ID: 7566580

Calcitriol dosing altered ionized calcium and PTH thresholds in dialysis patients — relevant to mineral homeostasis and bone metabolism.

PubMed ID: 7752008

Preterm infants fed nutrient‑enriched (higher‑calcium) formula reached normal mineral status without upsetting balance—relevant to neonatal bone accretion.

PubMed ID: 7781871

RCT reported markedly less vertebral BMD loss with active therapy — highly relevant to maintaining bone density.

PubMed ID: 7580056

Small DBPC comparison included a calcium control arm; lumbar BMD decreased in the calcium group over the study period — directly measured BMD.

PubMed ID: 8998681

Calcium+vitamin D maintained lumbar spine BMD over 2 years in corticosteroid users (calcitonin provided no added benefit).

PubMed ID: 8970899

Randomized, double‑blind placebo‑controlled trial showing significant reduction in incident spine fractures with 1.2 g/day calcium in elderly women with low intake.

PubMed ID: 8967706

Calcium + vitamin D prevented spine and trochanter bone loss in steroid‑treated RA patients—direct BMD preservation evidence.

PubMed ID: 8694013

Fortifying feeds for preterm infants increased plasma calcium and improved growth when breast milk predominated—direct pediatric bone/growth relevance (multinutrient intervention).

PubMed ID: 8599316

Physiologic increases in calcium absorption post-weaning support restoration of maternal bone stores—relevant to overall skeletal wellbeing.

PubMed ID: 8845601

RCT: increased dietary calcium reduced bone resorption and preserved/increased BMD — direct evidence for maintaining bone density.

PubMed ID: 8883115

Randomized trial in teenage girls: 500 mg elemental calcium daily produced significantly greater gains in bone mass/density over 2 years—direct evidence for supporting bone growth.

PubMed ID: 8997677

Porous calcium carbonate implant used with guided tissue regeneration produced measurable periodontal regeneration—direct bone-healing application.

PubMed ID: 8661952

RCT in elderly women: calcium supplement produced sustained increases in lumbar-spine BMD vs placebo.

PubMed ID: 8781044

High-calcium mineral water group had less radius bone loss than low-calcium—supports maintenance of bone density.

PubMed ID: 8906139

Study in preterm infants: a fortifier with higher mineral (including calcium) increased serum calcium and reduced alkaline phosphatase—directly relevant to infant bone mineralization/growth.

PubMed ID: 8794428

Direct RCT evidence that 1 g/day calcium prevented expected postmenopausal bone loss—strong support for general skeletal wellbeing.

PubMed ID: 8805994

Calcitriol increased bone-formation markers and serum calcium—supports anabolic bone effects via calcium/Vit D pathway.

PubMed ID: 8642490

Weaning cereal fiber had no adverse effect on calcium absorption in infants—relevant to dietary strategies supporting bone growth.

PubMed ID: 9026268

2-year data showing improved lumbar BMD with intervention where calcium was supplied—supports skeletal wellbeing.

PubMed ID: 8772604

1000 mg Ca prevented spine and hip BMD loss over 2 years in postmenopausal women on T4 suppression—strong direct effect on BMD.

PubMed ID: 8633378

Calcium plus alphacalcidol reduced BMD loss post–cardiac transplant and lowered fracture incidence vs etidronate+calcium.

PubMed ID: 8703705

Oral calcium loading in adolescents showed greater urinary calcium excretion in older teens, indicating age-related calcium handling important for growth.

PubMed ID: 8883116

Alfacalcidol increased fractional calcium absorption and reduced PTH in elderly women—mechanistically supports BMD maintenance.

PubMed ID: 8883119

Direct randomized data showing calcium (500 mg/day) as comparator and improved skeletal parameters when combined with active therapy — central evidence for skeletal wellbeing.

PubMed ID: 8774056

Alendronate treatment increased spine/femoral BMD and altered calcium/PTH — informs calcium homeostasis in BMD maintenance.

PubMed ID: 8640056

Preterm infants fed more human milk had higher bone mineral content at age five — direct evidence linking early diet to bone accrual in children.

PubMed ID: 8923359

Calcitonin + calcium preserved/increased multiple femoral/spine BMD measures vs calcium alone — strong support for calcium's role in skeletal health context.

PubMed ID: 8805993

Clodronate reduced urinary calcium loss and increased spine BMD with calcium background therapy — demonstrates clinically relevant skeletal benefits linked to calcium metabolism.

PubMed ID: 8732558

Study in very low birthweight infants: continued premature‑formula feeding (with higher Ca/P) improved bone markers and some growth measures — relevant to bone growth.

PubMed ID: 8557151

MPA added to GnRH therapy prevented treatment‑related rise in urinary calcium, implying preservation of calcium balance and potential bone density protection.

PubMed ID: 8704358

Direct randomized comparison showing large lumbar BMD gains with monofluorophosphate + Ca vs Ca alone in steroid‑treated patients.

PubMed ID: 9005368

Ipriflavone prevented radial bone loss induced by GnRH analog therapy — direct bone‑density preservation data.

PubMed ID: 9014744

Clodronate plus chemo normalized bone‑resorption markers in multiple myeloma — shows interventions can halt bone loss (indirectly relevant to Ca strategies).

PubMed ID: 9278463

Ca+D arm had significantly fewer nonvertebral fractures versus placebo—direct trial evidence of fracture risk reduction.

PubMed ID: 9077538

Randomized trial in prepubertal girls: daily calcium‑enriched foods increased regional bone mass accrual—strong direct evidence for supporting bone growth in children.

PubMed ID: 9205634

Randomized, double‑blind twin study in adolescent girls: 1000 mg/day calcium produced modest but statistically significant spine and hip BMD increases—direct evidence for supporting bone growth during adolescence.

PubMed ID: 9111393

Local collagen–calcium phosphate composite graft healed long‑bone fractures as well as autograft—direct evidence that a calcium‑containing bone graft material supports bone healing.

PubMed ID: 9334792

Decision aid substantially improved adherence to personal calcium intake plans for 12 months — strong behavioral support for sustained skeletal-nutrient intake.

PubMed ID: 9164808

Higher-mineral infant formula increased early BMC — direct evidence that greater calcium/mineral intake increases bone mass in infants (short-term).

PubMed ID: 9099188

Randomized trial in hemiplegic stroke patients: active vitamin D plus background calcium associated with fewer hip fractures vs placebo (0 vs 4) — fracture reduction observed, though vitamin D confounds attribution.

PubMed ID: 9388377

Strong randomized evidence: active vitamin D + calcium increased lumbar spine BMD and reduced vertebral fractures in elderly osteoporotic patients.

PubMed ID: 9491191

Preterm infants receiving Ca/P‑enriched formula had significantly greater radial BMC and bone width at 3 months — direct support for bone growth in infants.

PubMed ID: 9385282

Intranasal calcitonin with background calcium produced large, sustained BMD increases at 6 and 12 months vs placebo.

PubMed ID: 9284696

Cyclical etidronate given together with calcium produced significant increases in spinal and femoral BMD versus calcium/placebo over 2 years.

PubMed ID: 9236262

Ipriflavone plus 1 g/day calcium prevented spinal bone loss compared with calcium alone in postmenopausal women.

PubMed ID: 9164833

Monthly calcium slowed bone loss after wrist fracture in elderly women—direct clinical evidence that calcium supplementation preserves bone density.

PubMed ID: 9382122

Ibandronate trial included 1 g calcium/day background for all participants—calcium contributed to maintained BMD though primary effects were from the bisphosphonate.

PubMed ID: 9263613

Background calcium with active therapy produced favorable BMD and turnover changes—supportive of skeletal wellbeing in conjunction with other agents.

PubMed ID: 9145087

Dietary study in 2–24 month infants found calcium intake generally adequate from dairy—directly relevant to supporting early bone growth.

PubMed ID: 9259248

Long-term regimen (etidronate + vitamin D3 + calcium) increased spine BMD; calcium likely contributed although effect cannot be attributed solely to calcium.

PubMed ID: 9102058

Four‑year randomized data: higher calcium intake group avoided bone loss at hip and ankle vs lower-intake controls — strong evidence for maintaining BMD in older women.

PubMed ID: 9522322

Direct calcium supplementation (1000 mg/day) in oophorectomized women failed to prevent BMD loss — strong directly relevant evidence about Ca and BMD maintenance (shows limitation of Ca alone).

PubMed ID: 9202789

Direct randomized supplementation in children with low calcium intake produced a clear increase in radial bone mass acquisition during 18 months of supplementation (strongest direct pediatric evidence in the dataset).

PubMed ID: 9205633

Trial where calcium 500 mg/day was baseline and etidronate effect assessed — provides strong contextual evidence about calcium as standard skeletal therapy in early postmenopausal women.

PubMed ID: 9166391

Ipriflavone trial with daily calcium 1 g provided data showing preservation of radial BMD — directly relevant as background evidence for calcium's role in skeletal health when given at higher doses.

PubMed ID: 9489064

In steroid-treated patients, Ca was given to all; adding etidronate produced substantial spine BMD gains — demonstrates clinical context where Ca is part of bone-preserving therapy.

PubMed ID: 9263612

Ipriflavone plus Ca maintained BMD and lowered turnover vs placebo+Ca, indicating Ca's role as baseline therapy in maintaining bone density.

PubMed ID: 9797910

RCT evidence of increased lumbar spine BMD with calcium+vitamin D supplementation in early postmenopausal women.

PubMed ID: 9626637

Calcium during calorie-restriction reduced bone turnover and normalized PTH, supporting skeletal integrity under stress.

PubMed ID: 9625104

1200 mg/day calcium produced robust reductions in biochemical markers of bone resorption in postmenopausal women—direct support for maintaining BMD.

PubMed ID: 9738713

Nutrient-enriched formula with higher calcium improved bone mineral accrual in preterm infants, though multiple nutrients contributed.

PubMed ID: 9814452

RCT in older women: ~1000 mg/day Ca carbonate prevented hip bone loss and increased spine and femoral neck BMD — clear support for stronger bones.

PubMed ID: 9495509

Large 4‑yr RCT: Ca citrate 1600 mg/day modestly preserved hip BMD and lowered PTH — strong direct evidence for bone‑strengthening effects.

PubMed ID: 9724682

Shows low BMD and high urinary calcium loss in myelomeningocele patients—emphasizes the role of calcium balance in maintaining skeletal health in at‑risk groups.

PubMed ID: 9564795

Direct RCT evidence that 1000 mg/day calcium prevented lumbar-spine bone loss in steroid-treated patients — strong support for skeletal wellbeing in at-risk adults.

PubMed ID: 9880180

Hydroxyapatite/tricalcium-phosphate coating (calcium phosphate materials) on tibial components improved radiographic stability and reduced radiolucent lines versus uncoated implants — supports use of calcium-containing materials to enhance bone-implant fixation and healing.

PubMed ID: 9718191

Vitamin D (oral or UV-B) raised 25(OH)D, increased serum calcium and lowered PTH in very elderly; improved mineral metabolism supports skeletal wellbeing.

PubMed ID: 9797906

Vitamin D dose–response strongly affects vitamin D metabolites and thus calcium absorption, directly relevant to bone strength (indirect but high relevance).

PubMed ID: 9718903

Directly reports substantially lower bone mineral density in children with sickle cell disease — strong relevance to bone strength discussions.

PubMed ID: 9718538

Exercise program that stopped additional wrist bone loss over a year — direct evidence relevant to maintaining bone density.

PubMed ID: 9734615

Study in children on peritoneal dialysis: calcitriol raised serum calcium and markedly lowered PTH — directly relevant to pediatric bone mineral metabolism.

PubMed ID: 9771208

Strongest direct evidence in dataset showing BMD improvements in a calcium-supplemented treatment context.

PubMed ID: 9692071

Calcium + vitamin D modestly increased lumbar spine BMD in postmenopausal women.

PubMed ID: 10622084

Trial where all received calcium (1000 mg/day) showed that intranasal calcitonin on top of calcium reduced fractures vs placebo—calcium provided baseline support for fracture prevention by other therapy.

PubMed ID: 9988142

Adding oral calcium in dialysis patients lowered PTH substantially—beneficial for CKD–bone disease management and skeletal health.

PubMed ID: 10375338

Elderly women on low‑dose HRT with calcium/vitamin D had spinal BMD increases; calcium was provided to all, so contribution likely supportive.

PubMed ID: 10524386

Three‑servings-of-milk intervention increased calcium intake, lowered PTH and urinary N‑telopeptide (−13%) within 12 weeks—supports preservation of bone mass.

PubMed ID: 10451461

Randomized trial in Nigerian children with rickets: daily calcium (±vitamin D) produced large serum calcium increases and radiographic healing—direct, high‑certainty evidence of supporting bone growth/repair in children.

PubMed ID: 11329114

Randomized trial: 800 mg/day calcium citrate stabilized/increased L2–L4 and radial BMD vs placebo—direct evidence for maintaining bone density.

PubMed ID: 9925837

Improved calcium retention/serum calcium with feeding strategies in preterm infants suggests better mineral availability for healing/remodeling.

PubMed ID: 10511362

Maternal Ca (2 g/day) increased neonatal BMC in low‑intake mothers—supports fetal/early infant bone growth.

PubMed ID: 10539755

Infant formula modification increased Ca absorption and whole‑body BMC—direct evidence supporting bone growth in infants.

PubMed ID: 10367032

Alfacalcidol prevented steroid-related spinal bone loss—strong evidence for skeletal protection via Ca/Vit D pathways.

PubMed ID: 10494875

Observational study showing many girls/women had calcium intakes below recommendations and bone mass rose with puberty — directly relevant to calcium's role in pediatric bone growth.

PubMed ID: 10480411

Heart-transplant recipients given 1000 mg/day Ca showed improved lumbar-spine BMD over 3 years — direct evidence calcium contributes to maintaining BMD in this clinical setting.

PubMed ID: 10372699

Randomized trial in girls: 1 g/day Ca prevented BMD loss and preserved normal bone mass accrual during GnRHa therapy — strong pediatric evidence.

PubMed ID: 9920080

Calcium + vitamin D lowered bone resorption markers and had additive effects with estrogen in elderly women — supports maintenance of BMD.

PubMed ID: 10591421

Infant formula study: higher calcium intake and retention with certain formula supports mineral accretion during early growth.

PubMed ID: 10692976

In amenorrheic athletes Ca (given as part of therapy) was associated with BMD improvements when menses returned — Ca played supportive role for BMD (indirect).

PubMed ID: 10501793

Randomized trial with a calcium‑alone arm showing reduced femoral bone loss after transplant—strong direct evidence for maintaining BMD in that setting.

PubMed ID: 10234578

In infants, dietary calcium intake associated with total body BMC and modified response to gross motor activity on bone accrual.

PubMed ID: 9951784

Calcium+calcitriol largely prevented forearm BMD loss after pamidronate; direct evidence of maintaining BMD.

PubMed ID: 10550446

Dose‑dependent lumbar spine BMD gains with weekly hPTH in osteoporotic patients — relevant to maintaining/increasing BMD.

PubMed ID: 11864514

Randomized trial showing high calcium (~1500 mg/d) preserved maternal BMD through pregnancy/postpartum.

PubMed ID: 9917487

Infant formula fat blends affect stool via calcium‑soap formation — impacts calcium bioavailability and infant mineralization.

PubMed ID: 10487657

Combined HRT+MFP with background calcium produced large increases in spine BMD — strong support for skeletal wellbeing in postmenopausal women.

PubMed ID: 10369728

Estrogen plus vitamin D increased spine/femur BMD — demonstrates interventions improving skeletal wellbeing with calcium as background.

PubMed ID: 10191737

Calcium‑phosphate bone cement allowed quicker early functional recovery after distal radius fractures—direct aid to bone healing/recovery.

PubMed ID: 10554126

Preterm infants given mineral (including calcium) had +36% radial BMC at 3 months — direct child bone growth benefit.

PubMed ID: 10525709

Alendronate strongly increased lumbar BMD over 48 weeks; shows interventions affecting bone turnover and calcium homeostasis can maintain/increase density (drug context).

PubMed ID: 10599715

Infant vitamin D supplementation led to higher BMD in prepubertal girls, supporting a role for optimized calcium metabolism in achieving stronger bones.

PubMed ID: 10202741

Ossein-hydroxyapatite added to HRT produced notable vertebral bone mass increase, supporting maintenance/improvement of bone density.

PubMed ID: 10406437

Interactive calcium education led to better intake assessment and planning—practical intervention that can support overall skeletal health by improving calcium behaviors.

PubMed ID: 10367046

All arms received 1000 mg/day calcium; calcium-alone arm lost spine BMD over 3 years—shows calcium monotherapy may be insufficient to maintain BMD in osteoporosis.

PubMed ID: 10474019

Ipriflavone prevented spine BMD loss while calcium-lactate alone associated with a small decline over 1 year—calcium alone provided limited protection.

PubMed ID: 10442322

2-yr trial: calcium carbonate alone did not prevent bone loss in postmenopausal women—direct evidence concerning calcium supplementation and BMD maintenance.

PubMed ID: 10541760

Alendronate+calcium increased lumbar spine and radius BMD while calcium alone was associated with small declines—strong comparator evidence about calcium's role as baseline therapy.

PubMed ID: 11180916

Osteoporosis randomized trial shows calcium-only arm lost BMD while vitamin combinations improved BMD — strong contextual evidence that calcium alone is insufficient and that combinations matter for skeletal wellbeing.

PubMed ID: 11108415

Post‑hip‑fracture nutritional supplement including 800 mg calcium reduced in‑hospital and total complications — suggests calcium may aid recovery/healing context.

PubMed ID: 10966893

Shows BMD gains with Ca+vitD in elderly are lost after stopping — demonstrates impact on BMD but need for continued intake.

PubMed ID: 10911771

Younger (premenopausal) women showed ~+1% total‑body BMD over 12 months with calcium intake — supportive but smaller effect than adolescent data.

PubMed ID: 11395985

Teen girls receiving extra dairy/calcium had substantial trochanter and femoral‑neck BMD gains — direct evidence supporting bone growth.

PubMed ID: 10999778

750 mg/day calcium prevented hip BMD loss over 4 years — direct, high-quality evidence for maintaining bone density.

PubMed ID: 10714913

Early postmenopausal RCT showed calcium alone did not prevent bone loss — directly relevant as counter-evidence.

PubMed ID: 10846514

Multimicronutrient foods including calcium slightly increased bone density/mass in frail elderly.

PubMed ID: 11127214

Etidronate reduced hemiplegic‑side BMD loss and altered serum calcium—relevant to maintaining bone density.

PubMed ID: 10951511

Vitamin D3 and K1 improved markers tied to bone metabolism and osteocalcin carboxylation—supports BMD maintenance indirectly.

PubMed ID: 10929446

Alfacalcidol with higher calcium led to spine BMD gains in steroid users—direct maintenance effect.

PubMed ID: 10988110

Pamidronate + Ca/VitD produced large BMD increases versus Ca/VitD alone—calcium was background therapy.

PubMed ID: 10787766

Education program raised calcium intake and prevented BMC loss—strong evidence for maintaining bone density.

PubMed ID: 10656205

Fluoride added to calcium/vitamin D increased lumbar spine Z‑score while Ca/D alone did not—BMD outcome relevant.

PubMed ID: 10977001

Calcitriol plus calcium reduced hip bone loss vs calcium alone—strong maintenance signal.

PubMed ID: 11062355

Alendronate (with 500 mg Ca) produced spine and femoral neck BMD gains—relevant to maintenance.

PubMed ID: 10663363

Risedronate (with background calcium) reduced new vertebral fracture risk by ~49%—direct fracture outcome.

PubMed ID: 10620210

Calcium carbonate lowered PTH in secondary hyperparathyroidism, relevant to maintaining skeletal homeostasis.

PubMed ID: 10663358

Calcitriol preserved/increased calcium absorption in some subgroups, supporting skeletal mineral availability when calcium is consumed.

PubMed ID: 10648270

Randomized supplementation in deficient children improved BMC/BMD, a broad indicator of skeletal health.

PubMed ID: 10990311

Calcium‑based bone cement in distal radius fractures improved radiographic alignment, reduced malunion rate and improved one‑year function — strong evidence for aiding bone healing/recovery.

PubMed ID: 10996576

Spine BMD increased modestly in a large trial where calcium + vitamin D were background supplements.

PubMed ID: 11127759

Postmenopausal BMD gains reported in women receiving calcium alongside active therapy; calcium contributed as background bone-maintenance therapy.

PubMed ID: 11006178

All patients received 1500 mg calcium/day; significant spinal/femoral neck BMD increases were observed with active treatments (calcium as part of regimen).

PubMed ID: 11218508

Natural coral‑calcium bone graft substantially improved surgical periodontal bone healing metrics — strong direct evidence for localized bone healing aid.

PubMed ID: 11293237

Substantial reduction in skeletal complications and correction of hypercalcaemia indicate meaningful positive effects on skeletal morbidity.

PubMed ID: 11045316

Clear improvements in biochemical bone health markers and PTH suppression — strong support for skeletal wellbeing in the studied population.

PubMed ID: 10749632

Porous calcium phosphate ceramic blocks used as bone graft substitute with successful incorporation—direct evidence for aiding bone healing in surgical settings.

PubMed ID: 11522557

Demonstrates dose-dependent increases in ionized calcium and PTH suppression — mechanistic basis for maintaining bone density.

PubMed ID: 11149479

High-impact jumping increased hip and spine bone mass in children — clear direct evidence supporting bone accrual in growth phase (calcium intake recorded).

PubMed ID: 11587253

Calcium‑fortified milk reduced early postmenopausal spine bone loss and lowered bone resorption markers in a randomized trial.

PubMed ID: 11531934

Addition of 1alpha-hydroxyvitamin D3 to HRT+calcium produced larger spine BMD gains than HRT+calcium alone over 2 years.

PubMed ID: 11297596

Adding vitamin D to calcium reduced PTH and increased 25OHD in elderly women — changes that support maintenance of bone density.

PubMed ID: 11502787

Calcitriol (affecting calcium absorption) increased spine/hip BMD, especially combined with HRT; relevant to maintaining bone density.

PubMed ID: 11149482

Resistance training produced modest hip BMD increases in women who received 600 mg/day calcium; supports bone maintenance in calcium‑replete subjects.

PubMed ID: 11547841

800 mg Ca/day trial in postmenopausal women significantly attenuated BMD loss at multiple sites—direct evidence for maintaining bone density.

PubMed ID: 11484098

Marked reduction (~90% relative) in new vertebral fractures when etidronate was added to calcium/alphacalcidol—direct fracture outcome in a calcium‑supplement context.

PubMed ID: 11486790

Orlistat produced vitamin D deficit and increased bone resorption markers; authors advise calcium + vitamin D to prevent bone loss.

PubMed ID: 11748341

All participants received 500 mg/day calcium and BMD differences favored prior treated group—supports role of calcium in maintaining BMD during follow‑up.

PubMed ID: 11787719

Premature infants fed fortified human milk with added calcium/phosphate tended to have slightly better bone mineral content—direct pediatric bone growth relevance.

PubMed ID: 11760845

Large study in preschool children found dietary calcium positively associated with total body bone area and bone mineral content — direct support for bone growth in kids.

PubMed ID: 11277275

Calcitriol or cyclical etidronate with calcium partly reduced early post‑transplant bone loss—direct BMD preservation evidence.

PubMed ID: 11165950

Risedronate regimens showed marked falls in bone resorption markers; calcium coadministration influenced PTH—relevant to BMD maintenance when calcium is used adjunctively.

PubMed ID: 11149478

Direct randomized evidence that 1 g/day calcium prevents lumbar spine BMC loss and lowers PTH during weight loss — strong support for skeletal wellbeing.

PubMed ID: 11675056

Randomized milk-derived calcium in prepubertal girls produced significant and persistent increases in BMD/BMC — direct, high-quality evidence for supporting bone growth in children.

PubMed ID: 11504259

Calcium sulfate pellets used as a graft substitute produced radiographic bone formation comparable to autograft in spinal fusion — direct, high-relevance evidence for aiding bone healing.

PubMed ID: 11172164

Large randomized trial where risedronate reduced hip-fracture risk in elderly women — directly relevant to fracture risk reduction (drug trial, not calcium supplementation).

PubMed ID: 11503113

Calcium‑containing hydroxyapatite/tricalcium‑phosphate coating preserved periprosthetic femoral bone (direct evidence of maintaining local bone density).

PubMed ID: 11740230

Study in premature infants showed interventions that prevented increases in urinary calcium/phosphate, relevant to neonatal calcium balance and bone mineralization (direct pediatric relevance).

PubMed ID: 11484097

High-dose calcium + vit D paired with exercise improved spine BMD in osteoporotic women—broad support for skeletal health.

PubMed ID: 11701687

Men with osteoporosis all had 500 mg Ca/day; BMD outcomes reported though primary comparison was drug therapy.

PubMed ID: 11547219

Educational intervention produced small but significant increases in dietary calcium intake in schoolchildren—directly relevant to supporting bone accrual during growth.

PubMed ID: 12474069

Modest calcium supplementation in low-intake PHPT patients produced a measurable femoral neck BMD increase over 1 year.

PubMed ID: 12088517

Study in girls near menarche showed increased calcium absorption with prebiotic supplementation—relevant for bone accrual in adolescents.

PubMed ID: 11991447

Large RCT: 1200 mg Ca + 800 IU D corrected vitamin D/PTH, prevented femoral neck bone loss vs placebo.

PubMed ID: 11784873

Large RCT: normal dietary calcium (vs low calcium) with dietary changes reduced kidney stone recurrence and favorably affected urinary oxalate—supports the importance of adequate calcium intake for overall mineral homeostasis.

PubMed ID: 12495258

High-calcium milk markedly reduced CTX within weeks—strong antiresorptive signal supporting maintenance of BMD.

PubMed ID: 12027147

Adding vitamin D to calcium in deficient postmenopausal women lowered PTH and improved 25(OH)D—favorable for bone maintenance.

PubMed ID: 11966500

Calcium + vitamin D increased lumbar spine BMD in osteoporotic IBD patients over 1 year.

PubMed ID: 12414850

Calcitriol (active vitamin D) plus ERT maintained greater spine BMD over discontinuation — relevant to density maintenance.

PubMed ID: 11889427

Calcitriol given with calcium resulted in large lumbar spine BMD gains in heart transplant recipients (calcium was part of the regimen).

PubMed ID: 12039990

Calcium + active vitamin D partially prevented early post‑transplant bone loss at spine and hip vs no treatment.

PubMed ID: 12198018

Randomized supplementation in Gambian children increased bone mineral acquisition (+5% forearm) and sustained some benefits after withdrawal — direct evidence for supporting bone growth.

PubMed ID: 11916767

In older adults, calcium+vitamin D supplementation helped preserve BMD in interaction with higher protein intake, supporting skeletal wellbeing with aging.

PubMed ID: 12064336

Eggshell calcium supplementation increased femoral neck BMD in postmenopausal women and reduced turnover markers, supporting skeletal health.

PubMed ID: 11882468

Large cross‑sectional study: higher milk (calcium source) intake associated with greater bone mass in adolescent girls, supporting dietary calcium's role in bone growth.

PubMed ID: 11994333

Prevented salt-induced urinary Ca loss and blunted increase in bone resorption marker—directly supports calcium balance and BMD preservation.

PubMed ID: 12500659

Preschool children given supplements including calcium showed greater height/weight gains; effect confounded by other nutrients.

PubMed ID: 12521277

Randomized trial in infants with nutritional rickets showing biochemical and radiographic improvement with calcium (especially combined with vitamin D).

PubMed ID: 12459934

Large BMD gains reported in postmenopausal women receiving strontium with background calcium (500 mg/day) — calcium present as co-therapy.

PubMed ID: 12020142

Alendronate trial in elderly women with calcium/vit D background showed marked preservation/increases in spine and hip BMD.

PubMed ID: 12050252

Alendronate produced significant BMD gains in women receiving daily calcium and vitamin D — supplementation present as co-therapy.

PubMed ID: 11874228

School jumping program increased hip BMD and estimated strength in early-pubertal girls — directly relevant to optimizing bone accrual in youth.

PubMed ID: 11943033

Large fracture trial where Ca supplementation was commonly provided as background — contextual support for Ca in bone maintenance.

PubMed ID: 12086353

Alendronate + Ca vs Ca alone over 4 years — shows Ca was an active background bone‑support therapy; BMD differences reported.

PubMed ID: 12572358

Randomized adolescent trial where 300 mg/day calcium modestly increased bone mineral content—direct evidence for supporting bone growth.

PubMed ID: 12657345

Nightly 1200 mg calcium in late pregnancy reduced urinary NTX (~14%), a marker of bone resorption—supports preservation of maternal bone during pregnancy.

PubMed ID: 12510818

In pre/early‑pubertal girls calcium (especially with exercise) produced measurable increases in regional bone mineral content over ~8.5 months—direct support for bone growth.

PubMed ID: 12733728

Randomized trial in 3–5‑year‑olds showed calcium supplementation increased tibial cortical dimensions and augmented activity‑related bone gains—strong direct evidence.

PubMed ID: 12663301

Randomized 1000 mg/day calcium in adolescent girls increased whole-body and hip BMC—strong direct evidence for childhood bone growth.

PubMed ID: 12915959

High-calcium milk RCT reduced bone loss at spine/hip over 24 months—strong direct support for maintaining BMD.

PubMed ID: 12737020

Calcium carbonate raised serum calcium, suppressed PTH and reduced a bone resorption marker—supports mechanisms to maintain BMD.

PubMed ID: 12904840

Nutritional supplement including 1 g calcium + vitamin D produced large drop in bone resorption in underweight elderly, supporting bone strength.

PubMed ID: 15040824

Large cluster-randomized intervention with Ca 1000 mg + vit D 400 IU produced a statistically significant ~16% reduction in osteoporotic fractures.

PubMed ID: 12716689

Direct RCT evidence: 1000 mg Ca/day in early postmenopausal women associated with maintenance/gains in BMD over 2 years.

PubMed ID: 12629090

Direct randomized evidence: 1 g/day calcium in girls on GnRHa resulted in substantially greater increases in volumetric and AP spinal BMD during treatment and follow‑up.

PubMed ID: 14594787

Large RCT in teenage girls: 1000 mg/day calcium increased total‑body and lumbar spine BMD, especially >2 years post‑menarche — direct support for skeletal growth.

PubMed ID: 14602746

Calcium 500 mg + vitamin D significantly increased BMD and decreased PTH and resorption markers in elderly women.

PubMed ID: 12913194

Sunlight exposure study increased vitamin D and BMD and reported fewer hip fractures (1 vs 6) — strong indirect evidence via calcium metabolism.

PubMed ID: 14630841

Calcium‑phosphate cement used in distal radius fractures sped early functional recovery and reduced infection vs conventional fixation — strong direct evidence for a calcium‑based material aiding bone healing.

PubMed ID: 12728082

Infant formula composition that impairs calcium/fat absorption was associated with lower infant BMC/BMD—indicates calcium bioavailability critically affects bone growth in infants.

PubMed ID: 12929879

Clear healing of rickets with calcium confirms major positive impact on skeletal health in children with deficiency.

PubMed ID: 12823855

HRT on top of daily calcium+vitamin D improved BMD over 2 years in postmenopausal RA patients—calcium part of background therapy supporting BMD.

PubMed ID: 14506950

Calcium-containing multi-nutrient regimens plus vitamin K1 modestly preserved femoral‑neck BMD over 3 years (calcium present in regimen).

PubMed ID: 14610642

Trials of osteoporosis therapies with routine calcium supplementation show improved BMD and reduced turnover—indirect support for general skeletal wellbeing.

PubMed ID: 14569109

Alfacalcidol with CaCO3 prevented early post‑transplant bone loss (measured BMD increases vs declines in controls).

PubMed ID: 14513268

Alfacalcidol + calcium produced clear increases in lumbar spine and femoral neck BMD and large fracture reductions—strong evidence of maintained/improved density when calcium included.

PubMed ID: 12791633

Demonstrates that adequate calcium intake is important for maintaining higher BMD in older women — broad relevance to skeletal wellbeing.

PubMed ID: 14732982

Apexification/healing outcomes comparable for demineralized dentin matrix and calcium hydroxide—evidence of calcium compound aiding dental root healing.

PubMed ID: 14582545

Use of resorbable calcium–phosphate cement to augment screw fixation reduced early migration and improved mechanical stability—supports healing/stability.

PubMed ID: 15213038

Higher Ca intake increased absorbed calcium and prevented deleterious bone marker changes—supports skeletal health.

PubMed ID: 15231008

Winter Ca+D prevented seasonal bone loss and improved BMD measures—supports skeletal wellbeing.

PubMed ID: 15501704

Long randomized trial where Ca+D prevented bone loss—strong evidence supporting overall skeletal health.

PubMed ID: 15531696

One-year 500 mg/day Ca produced a small but significant increase in whole-body BMD in 12–14-year-old girls—direct pediatric bone growth evidence.

PubMed ID: 15386160

Elderly fracture patients given 1 g Ca + 800 IU D had higher fracture-site BMD at 6 weeks—direct evidence for faster early healing.

PubMed ID: 14722627

Calcium citrate reduced bone-resorption markers much more than carbonate—biochemical evidence for preserving bone density.

PubMed ID: 15448423

Fortified human milk in VLBW infants increased mineral intake and improved bone-related biochemistry and early growth.

PubMed ID: 15250845

Dietitian counseling increased dietary calcium intake among older patients with osteoporotic fractures — supports skeletal-wellbeing through improved intake.

PubMed ID: 15259281

Calcium formulations reduced bone formation markers and one improved spine BMD slightly — supports skeletal health.

PubMed ID: 15475040

Design paper for an intervention targeting higher calcium intake in teen girls — directly aimed at bone growth (no outcomes reported).

PubMed ID: 15447921

Epidemiologic and randomized-subgroup data linking higher dairy/calcium to preserved hip BMD in older men and reduced bone loss.

PubMed ID: 15230999

School milk (calcium) RCT in girls aged 10–12 increased height, total-body BMC and BMD over two years — direct high-quality evidence.

PubMed ID: 14973216

Post-heart-transplant bone-loss attenuation with calcitriol (Ca handling) demonstrates skeletal benefit in high-risk patients.

PubMed ID: 15502727

Direct evidence that calcium + calcitriol improved BMD at multiple sites in transplant patients—strong general skeletal benefit with Ca as part of regimen.

PubMed ID: 15295946

Mandibular bone mass improvement with calcium + vitamin D indicates oral/skeletal benefit.

PubMed ID: 15221494

Alfacalcidol + calcium decreased turnover and modestly increased lumbar BMD—beneficial for skeletal health.

PubMed ID: 14717945

Intermittent calcitriol + calcium preserved total hip BMD after renal transplant.

PubMed ID: 15024332

Immobilized hip-fracture patients: etidronate reduced resorption and improved calcium balance—direct clinical context of fracture/early recovery and mineral balance.

PubMed ID: 14695863

Vitamin D±calcium increased BMD and suppressed PTH in elderly post‑fracture women; calcium was part of the effective regimen.

PubMed ID: 15095035

Large randomized trial: higher‑dose milk powder Ca increased hip/spine BMD and total body BMD gains in children—direct, high‑quality evidence for bone growth.

PubMed ID: 14988448

High‑calcium dairy diet during weight loss attenuated increases in bone resorption markers, protecting bone density under catabolic conditions.

PubMed ID: 15572425

Demonstrated dose-dependent reductions in urinary calcium and modeled bone calcium retention over 3 years in postmenopausal women (supports maintenance of bone calcium).

PubMed ID: 15585774

Preterm infants receiving higher-calcium formula had large, direct increases in bone mineral content—strong pediatric evidence for calcium aiding bone growth.

PubMed ID: 15746990

Randomized comparison showed increasing calcium intake (~1.7 g/d) reduced bone loss during weight loss in postmenopausal women—strong direct evidence for maintaining BMD.

PubMed ID: 15472185

Randomized co-twin trial in premenarcheal girls: daily 1200 mg calcium produced significant increases in BMD and total body BMC over 12–18 months — direct evidence for supporting bone growth in children.

PubMed ID: 14749239

Early pubertal girls with higher fruit/veg intake had larger bone area and altered Ca/PTH—relevant to growth.

PubMed ID: 15359356

Switch to bicarbonate‑rich mineral water (containing Ca) increased ionized Ca, reduced PTH and bone resorption markers—favors bone maintenance.

PubMed ID: 15068495

Large 3‑year RCT showing clodronate halved vertebral fracture risk—direct fracture outcome evidence.

PubMed ID: 15365700

Longitudinal data show bone mass declines after menopause; factors (HRT) explained maintenance—context for bone density preservation.

PubMed ID: 15507508

Randomized trial in prepubertal girls: daily calcium supplements increased later bone mass gain—direct pediatric bone growth evidence.

PubMed ID: 15272899

DMD trial included Ca‑rich diet and vitamin D with prednisolone and showed prevention of scoliosis and prolonged ambulation—supports bone mass preservation.

PubMed ID: 15105027

After hip fracture, a high‑protein drink increased calcium intake and improved albumin—supportive for nutritional aid in bone healing.

PubMed ID: 14765851

Calcium‑based phosphate binders were associated with progression of vascular/valvular calcification—relevant negative effect to consider for general skeletal/vascular mineral balance.

PubMed ID: 15207760

Etidronate + calcium lactate regimen reduced early periprosthetic BMD loss after hip arthroplasty — direct BMD preservation with calcium present as adjunct.

PubMed ID: 15587751

Postmenopausal osteoporotic women all received 1000 mg/day calcium; addition of calcitriol produced measurable BMD increases — calcium was the baseline therapy supporting bone outcomes.

PubMed ID: 15031343

Alfacalcidol produced spine and femoral BMD increases in pre-dialysis renal failure; calcium/vitamin D axis strongly implicated.

PubMed ID: 15365658

Calcitonin nasal spray study included calcium/vitamin D co‑therapy and produced ~33% reductions in resorption markers — supports bone-strengthening biology where calcium participates.

PubMed ID: 15366587

Herbal Yigu capsule trial reported clinically meaningful BMD increases and reduced urinary Ca/Cr; calcium not sole agent but bone benefit observed.

PubMed ID: 15664001

Osteoporosis trial where all subjects received calcium+vitamin D; adding calcitonin produced greater spine and hip BMD gains — shows calcium as baseline supportive therapy for maintaining BMD.

PubMed ID: 15241158

HAP/TCP coating on femoral stems markedly reduced radiolucencies and improved osseointegration—strong evidence that calcium‑containing materials aid bone healing and integration.

PubMed ID: 15704046

Crohn's patients given Ca+D showed significant BMD increases—direct BMD evidence in a deficient group.

PubMed ID: 15895314

Pre‑menarchal girls: calcium plus exercise produced large BMD gains—strong evidence for supporting bone growth in children.

PubMed ID: 16087821

Risedronate on background of ergocalciferol + calcium substantially reduced fractures—calcium was co-therapy but the fracture benefit is primarily due to bisphosphonate.

PubMed ID: 15640478

Pubertal supplementation increased bone accrual during the growth spurt—robust randomized long‑term trial evidence.

PubMed ID: 15755866

Prepubertal boys had significant increases in limb aBMD with 850 mg/day calcium—direct pediatric growth effect.

PubMed ID: 16332231

rhPDGF added to a beta‑tricalcium phosphate matrix materially improved periodontal bone fill—strong evidence for calcium‑containing graft aiding local bone healing.

PubMed ID: 15668602

Higher-dose Ca+D fortified milk reduced bone resorption markers in postmenopausal women, supporting BMD preservation.

PubMed ID: 16280447

Food‑based calcium (cheese) showed some cortical bone advantages in prepubertal girls but effects were inconsistent after growth adjustment.

PubMed ID: 16283062

Observational/cohort evidence that higher calcium intake linked to modest BMD gains in postmenopausal women (supports density maintenance).

PubMed ID: 16491287

RCT: Ca+D fortified milk produced significantly less bone loss at clinically relevant sites in older men.

PubMed ID: 15817862

Metabolic study in adolescent girls showed differences in calcium retention and sensitivity to dietary salt—directly informative on calcium balance during growth.

PubMed ID: 16382319

Children on steroids randomized to Ca+D had far less BMD decline vs no supplementation (strong protective effect on bone density).

PubMed ID: 16007329

Sunlight exposure intervention including calcium increased BMD and reduced fractures in elderly women — strong bone-related benefit.

PubMed ID: 15841891

Pharmacist education increased the proportion of at-risk glucocorticoid patients taking calcium supplements — improves skeletal-care behaviors.

PubMed ID: 16858933

Bedtime calcium carbonate acutely lowered CTX and nighttime PTH — supports bone resorption suppression.

PubMed ID: 15744450

High-calcium mineral water (596 mg/day) lowered PTH and bone-resorption markers — supports bone strength.

PubMed ID: 16362456

CaCO3 and milk increased 24-h urinary calcium (absorption proxy) — indicates bioavailable calcium for bone mineralization.

PubMed ID: 15795602

Behavioral intervention in children with IBD increased daily calcium intake markedly — directly relevant to pediatric bone growth.

PubMed ID: 15681310

Behavioral program maintained/improved calcium intake in preadolescent girls—supports adequate intake during growth.

PubMed ID: 15883444

Calcium-fortified (±vit D) milk produced clear increases in periosteal diameter and cortical thickness in schoolgirls over 24 months.

PubMed ID: 15883634

VDR Fok1 genotype linked to lower calcium absorption and ~63 mg/day less skeletal calcium accretion during puberty (direct relevance to pediatric bone growth).

PubMed ID: 15910477

Calcium hydroxide lining protected dental pulp under restorations—evidence for local calcium material aiding tissue protection/healing.

PubMed ID: 15972580

Vitamin D analog ED‑71 increased spine/hip BMD with calcium background (supports density when combined therapy used).

PubMed ID: 15998785

Direct RCT evidence: increasing dairy-derived calcium protected hip and spine BMD in young women.

PubMed ID: 16076940

Adolescent study directly links vitamin D, PTH and calcium absorption — key determinants of bone accrual during growth.

PubMed ID: 15936361

Biphasic calcium phosphate ceramic used in PEEK cages led to complete cervical fusion and fewer donor-site problems — direct evidence calcium‑containing materials aid bone healing.

PubMed ID: 16094268

rhBMP‑2 delivered with a calcium‑phosphate carrier produced faster, higher‑grade spinal fusion vs iliac crest graft — strong evidence that calcium‑containing carriers enhance local bone healing in surgery.

PubMed ID: 16321186

In glucocorticoid-treated patients, calcium alone did not prevent BMD loss but was part of the regimen; addition of alfacalcidol preserved BMD — calcium necessary but not always sufficient.

PubMed ID: 15944165

Behavioral intervention successfully increased children's calcium intake to recommended levels — directly relevant to supporting bone growth in children (intake data).

PubMed ID: 15746294

Power resistance training preserved spine and hip BMD in postmenopausal women who were receiving calcium + vitamin D (calcium part of supportive therapy).

PubMed ID: 15811208

Ibandronate trial (background calcium + vitamin D) showed significant vertebral fracture risk reduction; calcium was given to all participants.

PubMed ID: 16418784

Large spine/hip BMD increases shown in trial where all patients received 1000 mg Ca + vitD—strong direct bone-density signal.

PubMed ID: 16129742

Resorbable calcium‑phosphate cement used in hip‑fracture fixation reduced early pain and improved early function—direct surgical bone‑healing adjunct.

PubMed ID: 16093464

Alendronate after PTH preserved/increased BMD substantially (calcium/vitD background)—strong evidence for maintained BMD.

PubMed ID: 15840055

Post‑transplant groups (all given 500 mg Ca/day) avoided the bone loss seen in controls when treated (Ca part of baseline regimen).

PubMed ID: 16352692

Continuing or switching antiresorptive therapy preserved/increased BMD in patients receiving Ca+VitD.

PubMed ID: 16109088

Short‑course alendronate preserved regional hip BMD in haemodialysis patients (relevant to preserving density).

PubMed ID: 15755856

Randomized trial in teenage boys: 1 g/day Ca for 13 months increased whole‑body and lumbar spine BMC and height—direct evidence for growth support.

PubMed ID: 15978968

Calcitonin markedly lowered turnover in osteoporotic women all on calcium—supports bone preservation when combined with Ca.

PubMed ID: 16336993

Behavioral intervention increased reported calcium intake in children—the study targeted child calcium intake and activity.

PubMed ID: 16437190

Post‑SCT patients lost hip bone despite calcium+vitamin D; bone biomarkers changed—directly examines bone density context where calcium was used.

PubMed ID: 16365721

Oily calcium hydroxide application during periodontal surgery produced significantly greater pocket reduction and attachment gain—direct evidence of calcium aiding local bone/periodontal healing.

PubMed ID: 15812582

Screening program that included recommending calcium+vitamin D reduced fracture incidence by ~56%—strong evidence linking calcium-containing recommendation to lower fractures at population level.

PubMed ID: 16131023

Randomized yogurt supplementation in preschool children increased height/weight gains and forearm BMD—direct evidence that dietary calcium supports bone growth in kids.

PubMed ID: 16481635

Large RCT: daily calcium+vitamin D produced a small but statistically significant hip BMD increase over ~7 years.

PubMed ID: 16945613

Five-year calcium RCT in older women showed sustained small increases in spine/hip/total body BMD.

PubMed ID: 16802360

Children with juvenile arthritis on calcium+vitamin D showed a small but significant total-body BMD increase over 2 years.

PubMed ID: 17342880

Short-term calcium supplementation in children improved bone ultrasound parameters linked to bone quality.

PubMed ID: 16895892

Metabolic balance study defined intakes for maximal calcium retention in adolescent boys (~1140 mg/day), informative for pediatric bone accrual.

PubMed ID: 16636212

1200 mg/day calcium produced measurable BMD and QUS improvements; benefits evident with good adherence.

PubMed ID: 16782422

Calcium with vitamins K1 and D improved lumbar spine BMC in a pediatric metabolic condition.

PubMed ID: 17181890

Fortified dairy Ca+vitD improved several BMD sites in postmenopausal women, while calcium pills alone did not.

PubMed ID: 16647414

Behavioral intervention raising dietary calcium in children produced larger gains in total and regional BMC over 12 months.

PubMed ID: 16430773

Behavioral intervention increased Ca use and led to measurable femoral neck BMD increases at one year.

PubMed ID: 16725396

Two-year fortified milk (1000 mg Ca + 800 IU D) reduced cortical bone loss and preserved strength indices in older men.

PubMed ID: 17030114

High-calcium milk reduced bone turnover markers in young women — consistent with maintenance/accumulation of BMD.

PubMed ID: 16837920

Lowering peritoneal dialysate Ca normalized bone formation in adynamic bone disease—strong contribution to skeletal wellbeing in PD patients.

PubMed ID: 17081815

GLP-2 robustly reduced bone resorption markers—favors skeletal maintenance if translated to long-term outcomes.

PubMed ID: 16426961

Micronutrient drink containing calcium produced modest improvements in growth and femoral neck BMD in schoolchildren over 14 months — supports bone growth though multi-nutrient.

PubMed ID: 17019522

Direct RCT in children: calcium addition produced minimal overall bone benefit but a clear pelvic BMC gain in prepubertal subgroup.

PubMed ID: 16785075

Demonstrated that recent oral calcium can change spine DXA measurements — important for interpreting 'maintain bone density' assessments.

PubMed ID: 17035614

Potassium citrate reduced urinary Ca and modestly increased spine/hip BMD — shows importance of calcium balance for maintaining BMD.

PubMed ID: 17061611

Adolescents with low calcium corrected biochemical deficits after 20 days of high-dose calcium — supports role in growth-stage bone metabolism.

PubMed ID: 16752286

Randomized trial testing calcium phosphate cement augmentation around screws in femoral neck fracture fixation—direct test of a calcium-based material in bone healing (no durable benefit found).

PubMed ID: 16231362

Women with anorexia: calcium plus vitamin D arm produced significant improvement in tibial bone measures versus control, directly supporting bone strength.

PubMed ID: 16960175

Demonstrates that calcium‑replete intake (1200–1500 mg/day) influences PTH response to vitamin D and is contextually linked to bone loss risk assessment.

PubMed ID: 16753014

Adolescent girls with adequate calcium intake showed dose‑responsive vitamin D increases in bone mineral gains—direct evidence of bone accrual in youth when calcium is adequate.

PubMed ID: 16713432

In osteoporotic women receiving background calcium, adding alendronate markedly increased spine and trochanter BMD — calcium present as part of regimen supporting BMD maintenance.

PubMed ID: 16767525

High‑dose nasal PTH given with calcium/vitamin D increased lumbar spine BMD and bone formation markers — calcium was background but BMD gains are directly relevant.

PubMed ID: 17291843

Resistance training helped preserve/increase spine BMD—a broad contributor to skeletal wellbeing.

PubMed ID: 17092241

Enamel matrix derivative with tricalcium phosphate improved periodontal bone outcomes — directly relevant to bone/periodontal healing using calcium-containing graft.

PubMed ID: 16802637

Calcium hydroxide induced dentin bridging—supports dental hard tissue (part of skeletal system) wellbeing.

PubMed ID: 16937274

Risedronate once‑weekly/daily increased lumbar spine BMD; patients received calcium supplementation (though agent tested was bisphosphonate).

PubMed ID: 16953055

Adolescent girls had low dietary calcium intake and some vitamin D deficiency — directly relevant to bone accrual in youth.

PubMed ID: 18089701

5-year randomized data show calcium (particularly with vitamin D) preserved hip BMD and reduced bone turnover — direct and robust.

PubMed ID: 17243866

Calcium with vitamins D and K produced modest ultradistal radius BMC increases and improved bone biomarkers.

PubMed ID: 17616788

Preserved/increased lumbar spine BMD vs placebo over 12 months in recent-fracture patients receiving Ca+D.

PubMed ID: 17181396

Randomized trial in boys: calcium with exercise produced 2–3% extra BMC accrual at loaded sites—a direct benefit for bone growth.

PubMed ID: 17823446

Fortified dairy+vitD improved BMD and bone markers better than calcium pills—relevant to skeletal health though confounded by dairy/vitD.

PubMed ID: 17951496

Adolescent responders to inulin-type fructans had increased fractional calcium absorption and whole-body calcium accretion over one year (equivalent to ~+250 mg/day calcium) — relevant to bone growth.

PubMed ID: 17413095

Direct RCT evidence that higher calcium intake prevented bone loss during weight loss.

PubMed ID: 17339618

Significant increases in spine and hip BMD in PTH(1‑84) trial where calcium (700 mg/d) was coadministered—strong, direct bone‑density outcome.

PubMed ID: 17805074

Observational cohort: lower dietary calcium associated with higher stress‑fracture risk in female runners—supports role of calcium intake in fracture prevention (associative).

PubMed ID: 17914135

Children on a calcium trial: interactions of vitamin D/PTH with bone‑area and BMC accrual over ~2 years—directly relevant to pediatric bone growth.

PubMed ID: 17315084

Dietary milk supplement (calcium source) maintained higher calcium intake and preserved BMD vs controls — direct supportive evidence.

PubMed ID: 17498850

Post‑hip‑fracture patients receiving calcium+vitamin D (background) showed whole‑body BMD gains with nutritional intervention — pertinent to bone‑healing contexts.

PubMed ID: 17666123

Study validated a simple calcium intake checklist in 6–10‑year‑olds — directly relevant to assessing calcium intake supporting bone growth in children.

PubMed ID: 18179991

Strong observational link between low calcium and low hip BMD in fracture patients — broadly relevant to skeletal health status.

PubMed ID: 17643363

Dialysate calcium altered PTH and bone turnover markers—relevant to maintenance of bone mineral homeostasis.

PubMed ID: 17371886

Calcium + vitamin D were provided with alendronate in men on ADT who experienced BMD gains—calcium supports density maintenance as background therapy.

PubMed ID: 18033629

Osteoporotic men receiving calcium (1000 mg/day) alongside drug therapy had lumbar spine BMD increases.

PubMed ID: 17147487

Higher dietary calcium associated with better femoral geometry and strength indices—supports bone maintenance.

PubMed ID: 17766507

Adolescent girls avoiding milk consumed less calcium and had lower spinal BMC—direct evidence linking calcium intake and bone growth in adolescents.

PubMed ID: 17907482

Topical calcium–phosphate promoter reduced dentin sensitivity after periodontal therapy—direct dental/skeletal tissue benefit.

PubMed ID: 17457450

Population data of widespread low BMD tied to low calcium intake supports the central role of calcium in skeletal health at the population level.

PubMed ID: 18050368

Steroid-treated cohort receiving calcium/alfacalcidol showed modest spine BMD increases over long term (calcium part of background therapy).

PubMed ID: 17672261

Direct pulp-capping in primary molars with calcium hydroxide showed high success — relevant to dental/bony structures in children (local effect).

PubMed ID: 18410225

1000 mg calcium in elderly women produced small BMD effects—some support for skeletal maintenance in older adults.

PubMed ID: 18258639

Adolescent girls randomized to calcium had greater bone mineral accrual and lower bone turnover while taking supplements (direct evidence for supporting growth during youth).

PubMed ID: 18834243

Local calcium sulfate graft improved periodontal defect healing vs debridement — direct evidence that a calcium-based material can aid local bone/periodontal healing.

PubMed ID: 19001206

1200 mg/day calcium in men produced meaningful BMD increases and reduced bone turnover markers over 2 years (strong direct evidence for maintaining/increasing BMD).

PubMed ID: 18202180

Markedly improved dietary Ca bioavailability from biofortified carrots supports overall skeletal mineral supply.

PubMed ID: 18541589

Randomized 1200 mg/day Ca reduced minimal‑trauma fracture risk during active treatment — direct evidence for fracture risk reduction on treatment.

PubMed ID: 19030908

Bedtime Ca‑containing fermented milk reduced nocturnal bone resorption — supportive short‑term skeletal effect.

PubMed ID: 18940881

In people receiving Ca, bicarbonate reduced bone resorption markers and urinary Ca loss (favors bone density maintenance).

PubMed ID: 19035501

Direct evidence: 1,000 mg/day Ca increased total body BMD in children with JRA over 24 months.

PubMed ID: 18492840

Randomized diet providing ~1140 mg calcium/day significantly attenuated loss (or increased) BMD at whole body, lumbar spine and total hip over 12 months.

PubMed ID: 18433305

Large randomized trial in female Navy recruits: 2000 mg calcium + 800 IU vitamin D produced ~20% relative reduction in stress fractures (statistically significant).

PubMed ID: 19004038

In steroid-treated SLE patients, calcium (±calcitriol) largely preserved lumbar spine BMD though hip showed slight loss—mixed but shows some preservation of BMD.

PubMed ID: 18296324

Calcium‑fortified milk over 2 years increased size‑adjusted BMD in girls — direct evidence for maintaining/building bone density.

PubMed ID: 18180882

Milk‑based calcium supplementation prevented rickets and supported normal bone development in children — strong maintenance/accumulation effect.

PubMed ID: 18796517

Genistein improved BMD in women who all received Ca+D, indicating maintained/improved density in the context of adequate calcium intake.

PubMed ID: 19101754

In trial where all received calcium+D, adding minodronate reduced vertebral fractures by ~59%—calcium was background therapy.

PubMed ID: 18829901

Calcium phosphate cement reduced articular subsidence versus autograft in tibial plateau repair—direct surgical bone‑healing application of calcium material.

PubMed ID: 18791486

OHC vs calcium carbonate added to raloxifene showed better preservation of bone ultrasound measures; calcium formulation comparisons directly relevant to maintaining bone mass.

PubMed ID: 18840643

Direct study in adolescent boys: dietary calcium intake was the strongest predictor of calcium retention—strong support for calcium in bone growth.

PubMed ID: 19040000

In steroid users Ca was provided and alendronate+Ca increased BMD — supports role of Ca within skeletal-health regimens.

PubMed ID: 18409094

Young broiler study: insufficient dietary Ca impaired growth and bone strength—supports importance of adequate Ca for growth-phase bone development (animal model).

PubMed ID: 18996761

Combination of 1500 mg Ca with vitamin D repletion attenuated hip BMD loss after bariatric surgery — supports general skeletal health.

PubMed ID: 18492750

Cholecalciferol significantly raised 25(OH)D and lowered PTH in elderly women—improves Ca homeostasis relevant to skeletal health.

PubMed ID: 18767509

Vitapex (calcium-hydroxide/iodoform) in primary molar pulpectomy showed faster radiographic healing—local Ca-based material aiding tissue healing.

PubMed ID: 18259100

Alfacalcidol reduced iPTH and modestly raised serum calcium—actions that influence bone remodelling and density.

PubMed ID: 18945995

Strong PTH reductions with cinacalcet+vitamin D in dialysis patients—directly relevant to reducing bone turnover and maintaining density.

PubMed ID: 18569914

Monthly high‑dose vitamin D increased calcidiol and lowered PTH in CKD—favorable for bone density maintenance.

PubMed ID: 18302501

School‑based jumping program in adolescents increased multiple bone measures—directly relevant to bone growth in youth (exercise rather than supplement).

PubMed ID: 18762944

Large osteoporosis trial: calcium (with vitamin D) provided as standard background while risedronate substantially increased BMD.

PubMed ID: 18764946

Large diet study documented changes in calcium intake (%RNI) across popular diets—directly relevant to population skeletal nutrient adequacy.

PubMed ID: 18581891

Dialysis patients on calcium carbonate+calcitriol showed BMD improvements with added therapy — calcium included in bone‑density regimen.

PubMed ID: 19082847

Beta‑TCP (calcium phosphate) acted as a graft extender in spinal fusion with comparable outcomes and less donor morbidity — strong bone‑healing relevance.

PubMed ID: 18381542

Fortification of human milk increased calcium intake and modestly improved growth measurements in low‑birthweight infants — directly relevant to infant skeletal growth (multinutrient intervention).

PubMed ID: 18496340

Human spinal-fusion trial: beta-tricalcium phosphate + local bone achieved equivalent fusion to iliac-crest autograft—strong evidence for aiding bone healing in surgical context.

PubMed ID: 18301927

Beta-TCP in interbody cages produced high fusion rates (especially with anterior plating); direct human evidence supporting bone healing.

PubMed ID: 18705811

Direct study of calcium-containing bone substitute in sinus grafts demonstrating new bone formation and material resorption patterns — high relevance to bone healing.

PubMed ID: 19928484

Parent/child program increased dietary calcium and produced modest hip/femoral neck BMD gains in boys—direct evidence for stronger bones in growing children.

PubMed ID: 19905932

Biphasic calcium composite graft produced clinically meaningful periodontal defect healing—direct local evidence of calcium aiding bone repair.

PubMed ID: 19335074

Calcium‑phosphate graft with growth factor achieved histologic periodontal regeneration—supports bone-healing capacity of calcium-based grafts.

PubMed ID: 20026265

Large trial of strontium ranelate showed fracture risk reduction; subjects received calcium+vitamin D as background — calcium part of standard care though not isolated.

PubMed ID: 19185400

Calcium + vitamin D3 improved vitamin D status and reduced PTH in elderly CKD women — supports overall skeletal health.

PubMed ID: 19820600

Injectable calcium phosphate paste used to fill calcaneal fracture voids reduced radiographic collapse — direct evidence for a calcium-based material aiding bone healing.

PubMed ID: 19306955

Early-life nutrition linked to modestly higher adult bone mass in preterm infants — relevant to lifelong skeletal wellbeing.

PubMed ID: 19244376

Strong trial evidence: vitamin D + calcium fortification produced large improvements in 25(OH)D, lower PTH and increased BMD in elderly — broad skeletal benefit.

PubMed ID: 19139662

Trial of calcium‑phosphate cement in kyphoplasty relates to use of calcium‑based biomaterial for vertebral fracture repair — directly relevant to surgical bone healing, though mechanical failure risk noted.

PubMed ID: 19351725

Parathyroidectomy normalized calcium/PTH and led to significant spine and femoral neck BMD increases — direct evidence of improving/maintaining BMD when Ca/PTH corrected.

PubMed ID: 19814838

Observational study in pubertal girls with low Ca intake found higher (especially animal) protein linked to smaller bone mass gains — shows interactions relevant to calcium‑dependent bone accrual in youth.

PubMed ID: 19117833

Trial in HIV-infected children/adolescents used monthly vitamin D plus 1 g/day calcium and safely raised 25-OHD — directly relevant to supporting bone accrual/growth in youth (intervention included substantial calcium).

PubMed ID: 19939650

Fortified/enriched milk in children raised serum calcium and improved vascular markers — supports dietary calcium delivery in kids (multi-nutrient product).

PubMed ID: 19262561

Elderly RCT showing significant lumbar spine BMD increase over 12 months with a calcium‑containing product (Caltrate D as part of regimen).

PubMed ID: 19666939

Randomized trial in underprivileged toddlers: 500 mg daily calcium corrected hypocalcemia and reduced PTH—direct support for bone mineralization and growth in children.

PubMed ID: 20139574

Calcium phosphate cement significantly improved periodontal defect bone fill and attachment vs comparators—strong evidence for aiding local bone healing.

PubMed ID: 19296044

Milk intake reduced bone resorption markers and yielded small total BMD gains in young women—supports maintenance of bone density.

PubMed ID: 19728118

In osteoporotic women receiving Ca+vitD, loss of hip BMD over 1–3 years strongly predicted new fractures—links BMD (and by extension Ca adequacy) to fracture risk.

PubMed ID: 19865631

Human clinical trial: medical‑grade calcium sulfate filling of extraction sockets reduced ridge resorption and increased newly formed trabecular bone at 3 months—strong direct healing evidence.

PubMed ID: 20484446

Calcium supplementation during teriparatide treatment supported marked lumbar spine and hip BMD increases

PubMed ID: 20044757

Pregnant women receiving milk+calcium had higher spine and whole-body BMD vs controls

PubMed ID: 20204604

3-year vitamin D+calcium RCT showed a modest but significant increase in total-body BMD (maintains bone density)

PubMed ID: 20298784

Vitamin D analog data show strong suppression of bone resorption and increased calcium handling—relevant to skeletal health

PubMed ID: 20463100

Calcium lowered bone-turnover markers and reduced PTH after load—mechanistic evidence for skeletal health

PubMed ID: 21133980

Randomized trial: rhPDGF-BB + β‑tricalcium phosphate produced greater linear bone growth and percent bone fill in periodontal defects—strong evidence for calcium phosphate in bone healing

PubMed ID: 20544178

RCT in peripubertal girls showed significant increases in trabecular/cortical bone measures with Ca+vitD—direct evidence for bone growth support.

PubMed ID: 21153900

30-month fortified-dairy (Ca+vitD) RCT showed improved total body BMD and reduced bone turnover markers—strong direct evidence for maintaining BMD.

PubMed ID: 20193095

Ca+vitD RCT lowered PTH and produced femoral bone augmentation over 1 year—strong support for maintaining BMD.

PubMed ID: 21170641

Daily modest calcium from fortified ice cream rapidly suppressed bone resorption markers—supports preservation of bone density.

PubMed ID: 20709856

School intervention improved provision of calcium‑containing foods—supports skeletal wellbeing in children indirectly.

PubMed ID: 22254070

Population intervention increased calcium intake in older women—useful for public‑health skeletal wellbeing.

PubMed ID: 20460227

24‑month RCT of calcium carbonate in adolescents increased total body BMC and spine BMD in boys — direct evidence for supporting bone growth.

PubMed ID: 20546250

RhGDF‑5 with β‑TCP produced comparable new bone formation in sinus augmentation — direct clinical evidence for calcium‑based graft material aiding bone formation/healing.

PubMed ID: 20148911

Two‑year Ca 500 mg/day trial produced modest, measurable increases in lumbar and total hip BMD—direct maintenance/gain of bone density.

PubMed ID: 22254067

Education + bone‑density feedback increased calcium use and was associated with femoral neck BMD improvements.

PubMed ID: 20089725

Observational cohort in adolescent girls found higher dietary calcium associated with higher IGF‑I and IGFBP‑3, biomarkers that support growth and bone accrual.

PubMed ID: 20646099

Vitamin D regimens similarly lowered PTH (which affects bone resorption) and therefore influence bone density maintenance in older women.

PubMed ID: 20217116

Study in postmenopausal women maintained on adequate Ca+D showed higher sodium did not harm BMD—supports sufficiency of calcium/vitamin D to maintain density.

PubMed ID: 20657257

Calcium‑sulfate bone substitute used as antibiotic carrier eradicated infection similarly to PMMA but required fewer reoperations; calcium material central to bone healing context.

PubMed ID: 20709302

Young female runners with higher milk/dairy (calcium) intake had a markedly lower incidence of stress fractures (each extra cup associated with ~62% reduction).

PubMed ID: 20299186

Study in boys with low calcium intake: calcium-rich milk combined with exercise produced numerically greater femoral neck BMD gains over 6 months (confounded by exercise).

PubMed ID: 20370938

Fortified dairy providing ~1200 mg Ca + vitamin D for 30 months produced significant increases in spine and total-body BMD in postmenopausal women.

PubMed ID: 20662329

Randomized trial in preschool children: cereal with Ca + vitamin D increased spine BMD significantly over 9 months—strong evidence for supporting bone growth.

PubMed ID: 21029610

Combined regimens including calcium produced increases/stabilization in lumbar spine and femur BMD over 48 weeks — calcium was a component.

PubMed ID: 20708511

Calcium hydroxide intracanal medication with ultrasonic filing shortened time to apical barrier formation in immature teeth — clear evidence of faster mineralized‑tissue healing in a dental context.

PubMed ID: 20579524

Fortified milk increased serum calcium and osteocalcin (bone formation marker) over 1 year—supports bone‑strengthening biology though no direct BMD/fracture data.

PubMed ID: 20304051

Vitamin D in deficient older women suppressed CTX (bone resorption marker), supporting preservation of bone density.

PubMed ID: 20843402

The intervention increased calcium intake in female adolescents, directly relevant to supporting bone growth during development.

PubMed ID: 21245882

Daily calcium‑fortified snack (405 mg) + monthly vitamin D produced a large (statistically significant) increase in whole‑body BMC in underprivileged toddlers — strong direct evidence for supporting bone growth.

PubMed ID: 21896874

Improved calcium absorption/retention with supplementation in adolescents supports skeletal health during growth.

PubMed ID: 22035462

Comparative data showing modest BMD benefits of a specific calcium source in older osteoporotic women — relevant to skeletal wellbeing in older adults.

PubMed ID: 21392712

Adolescent dietary intervention successfully raised calcium intake to ~1,494 mg/day — highly relevant to bone accrual in youth.

PubMed ID: 22078660

All participants received calcium (1200 mg) + vitamin D and showed suppressed bone resorption marker and correlations with BMD changes — good biomarker support for maintaining bone density.

PubMed ID: 22155532

Weight‑bearing exercise + calcium‑rich milk in boys yielded the largest femoral neck BMD gains — direct support for bone growth in children.

PubMed ID: 21778673

Combination regimen including calcium increased BMD and reduced fractures in elderly patients — supports skeletal wellbeing though effect is not Ca‑isolated.

PubMed ID: 21784309

600 mg/day calcium tablets increased lumbar spine and hip BMD over 1 year in postpartum women — direct and strong evidence for maintaining/increasing BMD.

PubMed ID: 21843948

α‑tricalcium phosphate graft material promoted new bone formation after jaw surgery — direct clinical evidence of Ca‑based material aiding bone formation/healing.

PubMed ID: 21797917

Sinus grafting with β‑TCP (a Ca material) produced comparable new bone formation — supports Ca-containing grafts in bone healing.

PubMed ID: 21253392

Calcium + vitamin D increased lumbar spine BMD over multiple years in patients with low BMD—strong direct evidence for maintaining/increasing bone density.

PubMed ID: 22049177

Higher dairy/calcium intake during diet+exercise preserved favorable bone turnover markers and lowered PTH, supporting bone-density maintenance.

PubMed ID: 21593114

Calcium‑sensing receptor antagonist raised PTH and altered bone turnover with measurable BMD changes—demonstrates importance of calcium-related physiology for BMD.

PubMed ID: 21253715

Large randomized trial of daily 1000 mg calcium + 400 IU vitamin D produced modest but significant preservation of femoral neck BMD over years—direct evidence.

PubMed ID: 21725510

Patients with Crohn’s and osteoporosis receiving calcium+vitamin D (with other agents) experienced lumbar spine BMD increases over multi-year follow-up.

PubMed ID: 22214657

Guideline implementation increased dietary calcium advice — supports bone-strengthening public health measures.

PubMed ID: 22232815

Use of calcium sulphate cement in calcaneal fracture fixation associated with less blood loss and better early function — directly relevant to surgical bone-healing adjunct.

PubMed ID: 22130786

Adding alfacalcidol (vitamin D analog) suppressed PTH and produced larger spine BMD increases—relevant to calcium metabolism and BMD maintenance.

PubMed ID: 21773992

PTH therapy produced large changes in bone turnover and altered calcium/vitamin D needs—important for overall skeletal metabolism in hypoparathyroidism.

PubMed ID: 21240015

Randomized neonatal trial: higher parenteral calcium/phosphate prevented declines in bone-strength measure in very preterm infants—direct pediatric bone-growth evidence.

PubMed ID: 21251993

Inhaled steroid trial in children with added vitamin D altered calcium‑phosphorus balance and bone turnover markers—relevant to bone growth/health in pediatric patients on steroids.

PubMed ID: 30292451

Three-year trial showing high success of calcium-silicate dental materials for vital pulp therapy—long-term tooth health with Ca-based materials.

PubMed ID: 16161395

Mineral trioxide aggregate (calcium-containing) produced higher pulpotomy success vs formocresol — supports beneficial local calcium-based dental materials.

PubMed ID: 16301159

Calcium hydroxide mixed with chlorhexidine tended to improve root-canal disinfection (80% vs 60%)—direct dental use of calcium hydroxide with modest/ equivocal benefit.

PubMed ID: 16365721

Oily calcium hydroxide paste applied during periodontal surgery produced significantly greater pocket reduction and attachment gain—direct calcium-based dental/healing benefit.

PubMed ID: 16216093

Calcium hydroxide pulpotomy in children produced dentine bridges and moderate clinical/radiographic success—direct dental benefit of a calcium compound.

PubMed ID: 16004250

Topical calcium carbonate-containing toothpaste removed significantly more extrinsic stain than silica control in a randomized trial.

PubMed ID: 16764130

Direct RCT comparing calcium hydroxide pulp capping—improves dentin bridge formation and pulp vitality compared with alternatives.

PubMed ID: 16536148

Human trial: calcium hydroxide pulp capping produced dentin bridges in all teeth and less pulp inflammation vs adhesive—strong direct dental benefit.

PubMed ID: 16410062

Intracanal dressings including calcium hydroxide reduced cultivable bacteria — relevant to local dental health.

PubMed ID: 17092241

Periodontal regeneration trial used β‑tricalcium phosphate (calcium phosphate) and showed improved periodontal attachment and pocket depth — relevant to dental/periodontal bone support.

PubMed ID: 16802637

Calcium hydroxide pulp capping produced dentin bridging by 30 days — direct, strong evidence for tooth/odontoblast response to a calcium-based treatment.

PubMed ID: 17555692

Direct dental trial using calcium hydroxide for partial pulpotomy in permanent molars in children — strong direct relevance to dental health.

PubMed ID: 17376712

Calcium hydroxide used inside root canals detoxified endotoxin and altered LPS to improve antibody stimulation — direct dental application of a calcium compound.

PubMed ID: 17258626

Clinical intracanal trial: calcium hydroxide showed comparable antibacterial effects to alternatives in teeth with apical periodontitis.

PubMed ID: 17907482

Clinical trial: a calcium–phosphate–promoting agent (amorphous Ca–P promoter) reduced tooth root sensitivity after periodontal therapy—direct dental benefit of a calcium-promoting topical.

PubMed ID: 17672262

Indirect pulp treatment in primary molars: calcium-hydroxide liners had somewhat lower success than comparator but still showed moderate success—relevant to tooth preservation.

PubMed ID: 17672261

Direct pulp-capping trial in primary molars: calcium hydroxide (Dycal) performed well (~93% success at 2 years) — supports dental health use of calcium compounds.

PubMed ID: 18834243

Calcium sulfate graft improved periodontal defect healing vs debridement alone (local calcium material improves dental outcomes).

PubMed ID: 18166089

Calcium phosphate cement in periodontal defects produced radiographic bone gains in responsive cases — dental/bone relevance.

PubMed ID: 18485139

Dual‑phase remineralising toothpaste delivering soluble calcium/phosphate significantly reduced root caries in high‑risk radiation patients; direct oral health benefit.

PubMed ID: 19278083

Large clinical toothpaste study: a calcium carbonate‑based fluoride toothpaste reduced caries vs non‑fluoride control—direct clinical benefit to teeth where Ca‑carbonate was the formulation vehicle.

PubMed ID: 18767509

Primary molar root therapy: calcium-hydroxide paste (a Ca compound) produced faster radiographic healing at 6 months—direct dental/teeth-relevant evidence.

PubMed ID: 18489485

Injectable calcium hydroxide dressings clearly improved root‑canal obturation outcomes—direct dental application of a calcium compound.

PubMed ID: 18793361

Topical Ca(OH)2 intracanal dressing produced large reductions in root‑canal bacterial load — direct, strong dental benefit of a calcium compound.

PubMed ID: 18795515

Randomized human trial: calcium‑sodium‑phosphosilicate (NovaMin) dentifrice produced substantially greater reductions in dentin sensitivity and is a calcium-releasing agent promoting remineralization.

PubMed ID: 19905932

Biphasic calcium composite graft produced periodontal improvements comparable to autograft—direct clinical dental benefit.

PubMed ID: 19335074

Calcium‑phosphate graft with growth factor produced histologic periodontal regeneration—supports dental hard-tissue healing.

PubMed ID: 19201627

Clinical dental trial using calcium hydroxide pulp-capping material showed comparable clinical/radiographic outcomes — direct tooth-related calcium application.

PubMed ID: 20128316

RCT of a calcium/phosphate delivery toothpaste produced large, clinically meaningful reductions in dentinal sensitivity — direct, high‑relevance dental benefit.

PubMed ID: 19864905

Toothpaste with casein phosphopeptide in a calcium carbonate base significantly reduced new cavities in children, directly implicating calcium-based remineralization benefits.

PubMed ID: 19887683

CPP‑ACP (a calcium-containing topical) produced robust remineralization (31% more lesion regression) — strong direct dental benefit.

PubMed ID: 19648746

Use of calcium hydroxide cement in primary teeth after caries treatment produced similar microbial outcomes over follow‑up and supports restorative sealing approaches.

PubMed ID: 20139574

Clinical trial: calcium‑phosphate cement markedly improved probing depth and attachment level in periodontal bone defects—direct dental benefit.

PubMed ID: 19940476

Clinical enamel study measured calcium loss from enamel; treatment (dilute HF) temporarily reduced enamel solubility/calcium release—direct tooth‑mineral relevance.

PubMed ID: 20831450

Maternal calcium supplementation during pregnancy reduced dental caries risk in offspring at age 12 (randomized trial)

PubMed ID: 20675425

NovaMin (calcium‑containing bioactive glass) application reduced dentin hypersensitivity vs control toothpaste (small RCT)

PubMed ID: 20370417

Calcium sodium phosphosilicate dentifrice produced significantly greater reductions in dentin hypersensitivity vs placebo and potassium nitrate.

PubMed ID: 21207919

NovaMin (calcium‑phosphate releasing) toothpaste reduced dentin sensitivity and occluded tubules faster than comparator—strong dental benefit.

PubMed ID: 21207920

Topical calcium sodium phosphosilicate (NovaMin) dentifrice produced marked reductions in dentin sensitivity — strong direct dental calcium evidence.

PubMed ID: 20562409

Calcium‑enriched mixture used for pulpotomy showed similar or better clinical/radiographic outcomes vs root canal therapy — relevant to dental calcium materials.

PubMed ID: 20652790

Pulpotomy using a calcium‑enriched cement produced faster and greater pain relief and better radiographic outcomes vs root canal — direct calcium‑based dental product evidence.

PubMed ID: 20383545

Randomized human trial: topical CPP‑ACP (calcium‑phosphate complex) produced substantial regression of white spot lesions after orthodontics (large clinical effect vs baseline).

PubMed ID: 21070705

Pediatric pulpotomy trial: calcium‑containing MTA produced similar clinical success and better radiographic dentin bridge formation vs formocresol—direct evidence for calcium‑based dental materials improving tooth healing.

PubMed ID: 20708511

Using ultrasonic filing plus calcium hydroxide intracanal medication shortened time to apical barrier formation in immature teeth—direct clinical benefit of calcium‑based endodontic therapy.

PubMed ID: 20836956

Indirect pulp therapy (procedure often using calcium‑based liners) led to fewer pulp exposures than complete caries removal, supporting conservative tooth treatment outcomes.

PubMed ID: 20448584

Clinical study in primary molars: calcium hydroxide pulpotomy had higher success when restored with stainless steel crowns (clinically relevant pediatric dental outcome with calcium hydroxide).

PubMed ID: 21207918

Sodium calcium phosphosilicate (NovaMin) toothpaste significantly reduced dentin hypersensitivity vs placebo in RCTs—strong direct clinical dental benefit.

PubMed ID: 21250566

CPP-ACP cream (calcium/phosphate complex) significantly reduced lesion fluorescence, evidence for enamel remineralization.

PubMed ID: 20552099

Orthodontic cement releasing amorphous calcium phosphate showed similar bond strength and is relevant to local calcium-based dental interventions.

PubMed ID: 20298652

MTA (calcium‑based) pulpotomy had better radiographic outcomes and survival vs ferric sulfate; strong clinical dental evidence involving calcium material.

PubMed ID: 22211737

Randomized trial of calcium hydroxide (topical) partial pulpotomy in primary molars showed similar medium-term success to formocresol — strong direct dental therapeutic evidence for a calcium compound.

PubMed ID: 21875640

Human in situ trial: POs‑Ca chewing gum significantly increased enamel remineralization — direct evidence for local calcium benefit to teeth.

PubMed ID: 21555774

Vitamin D deficiency associated with worse periodontal healing post-surgery; indirectly implicates calcium metabolism in dental healing.

PubMed ID: 21750917

Randomized intraoral study: functionalized tricalcium phosphate + fluoride significantly improved enamel hardness and mineral recovery—direct dental calcium phosphate evidence.

PubMed ID: 22099892

Clinical study of calcium-containing dental cements showed reparative dentin formation and matrix proteins — directly relevant to tooth repair (material-level Ca).

PubMed ID: 22353416

Clinical pulpotomy trial using calcium hydroxide showed high 1‑year success—direct primary‑tooth clinical evidence for a calcium medicament.

PubMed ID: 22046693

Metapex (calcium hydroxide/iodoform) pulpectomies achieved 100% success vs alternatives — strong clinical dental evidence for a calcium‑containing endodontic product.

PubMed ID: 22077915

Calcium hydroxide–based intracanal medicaments reduced E. faecalis counts immediately — relevant to dental infection control using calcium‑based agents.

PubMed ID: 22077689

Calcium‑enriched mixture (CEM) produced favorable pulpotomy outcomes comparable to MTA over 2 years — good clinical evidence for calcium‑based dental biomaterial.

PubMed ID: 21354608

In vitro use of a calcium source with biomimetic analogs produced substantial dentin remineralization — mechanistic support for tooth mineral restoration.

PubMed ID: 22048576

MTA (a calcium‑containing material) outperformed formocresol in primary molar pulpotomy with superior hard‑tissue repair—strong dental relevance.

PubMed ID: 21378714

Antioxidant therapy combined with calcium‑D3 improved periodontal biochemical and clinical outcomes — shows calcium-containing supplement used in periodontal disease care.

PubMed ID: 21698987

Calcium sodium phosphosilicate-based desensitizing system reduced dentin hypersensitivity over 6 months in periodontitis patients — direct calcium-containing dental intervention.

PubMed ID: 22051486

Topical CPP-ACP (calcium/phosphate) markedly reduced enamel demineralization in RCT — strong direct evidence for tooth mineral health.

PubMed ID: 22309243

Clinical trial of a calcium‑enriched endodontic cement (CEM) in immature molars showed high pulp survival and apexogenesis — strong direct dental benefit from a calcium-containing material.

PubMed ID: 22339289

Large randomized trial: pulpotomy with calcium-containing biomaterial performed well for permanent molars — direct clinical dental evidence.

PubMed ID: 22703646

Root-end surgery using MTA (calcium‑containing) showed high 1‑year success — supports effectiveness of calcium‑based dental materials.

PubMed ID: 23265162

White MTA used in primary incisors showed clinical/radiographic success and dentin‑bridge formation — supports calcium‑releasing material aiding tooth repair.

PubMed ID: 23211896

Large pediatric RCT: gray MTA (calcium‑containing) produced higher radiographic success and dentin bridge formation vs formocresol — strong clinical evidence for calcium‑based material supporting tooth vitality/mineralization.

PubMed ID: 22305715

A calcium‑based biomimetic mineralization kit produced an enamel‑like layer, reduced dentin sensitivity and occluded tubules in a randomized clinical study.

PubMed ID: 23270285

Calcium‑hydroxide pulp capping in primary molars produced high clinical success and influenced radiographic success—clinical relevance for dental health.

PubMed ID: 22411260

A tricalcium‑silicate (calcium‑containing) dental material performed acceptably short‑term as a dentine substitute; relevant to tooth restoration materials.

PubMed ID: 22431145

Calcium-containing dental cement improved radiographic success versus root canal treatment — direct dental application of calcium-based material.

PubMed ID: 22782050

In‑mouth study: tricalcium phosphate adjunct with fluoride enhanced enamel remineralization — direct evidence for a calcium-containing product improving dental mineralization.

PubMed ID: 22736463

Supersaturated calcium‑phosphate rinse halved mucositis severity and sped oral recovery—benefits in oral mucosal/teeth environment.

PubMed ID: 23204096

Human in‑office bleaching RCT: inclusion of calcium in bleaching gel markedly reduced tooth sensitivity vs calcium‑free gel while maintaining whitening — strong, direct dental benefit.

PubMed ID: 23137292

Ex‑vivo root‑canal model used calcium hydroxide intracanal dressing (a calcium compound) showing bacterial reduction similar to controls — limited, indirect dental evidence.

PubMed ID: 22762173

Mineral trioxide aggregate (calcium‑based) performed well in primary molar pulpotomy—supports clinical use of calcium‑containing dental material.

PubMed ID: 23186566

Toothpaste with calcium sodium phosphosilicate significantly reduced dentinal hypersensitivity vs comparators — direct clinical dental benefit from a calcium‑containing product.

PubMed ID: 23003915

β‑TCP used as doxycycline carrier improved periodontal clinical outcomes—calcium phosphate biomaterial improved dental healing outcomes.

PubMed ID: 22838228

Clinical trial in immature teeth showed faster apical barrier formation and radiographic healing with MTA versus calcium hydroxide dressings, directly informing endodontic tooth healing outcomes.

PubMed ID: 23422605

Randomized trial in teenage females found a daily 500 mg calcium tablet reduced orthodontic pain—clinical dental pain benefit with oral calcium.

PubMed ID: 22324456

Human sinus augmentation trial comparing calcium‑based bone substitutes demonstrated new bone formation important for oral/dental rehabilitation.

PubMed ID: 23635884

CPP-ACP (calcium phosphate) remineralizing paste in young children reduced persistent mutans streptococci in some subgroups and low caries incidence.

PubMed ID: 24370194

Long-term dietary intervention: higher salivary calcium associated with less caries up to age 12—observational support for dental health.

PubMed ID: 24043482

IPT randomized comparisons: calcium hydroxide (Ca-based) had high clinical success in indirect pulp treatment—direct dental benefit.

PubMed ID: 23343804

Topical Ca‑containing cement (calcium hydroxide) produced dentin hardening after sealing.

PubMed ID: 23715201

Adjunct mineral wash with Ca compound improved dentin sensitivity and tubule occlusion.

PubMed ID: 24553281

CPP‑ACP (calcium‑phosphate complex) reduced mutans streptococci colonization in young children.

PubMed ID: 24461403

Regenerative endodontic treatments used materials (MTA) with calcium components and showed continued root development/healing.

PubMed ID: 23690353

Trial compared calcium hydroxide to MTA for pulp capping; involves calcium-based therapy in tooth preservation (dental outcome).

PubMed ID: 24693629

Calcium hydroxide indirect pulp capping improved dentin hardening and color versus inert material — direct dental benefit of a calcium compound.

PubMed ID: 23346907

Calcium hydroxide indirect pulp treatment in primary molars showed good longer-term success — direct pediatric dental calcium use.

PubMed ID: 24328607

Endodontic RCT included calcium hydroxide dressings; clinical radiographic outcomes relevant to periapical healing and tooth health.

PubMed ID: 23756301

MTA showed superior long‑term radiographic survival in primary molars — ties to calcium‑containing dental materials and tooth health.

PubMed ID: 24351693

Primary molar pulpotomy: MTA materials outperformed calcium hydroxide — directly relevant to dental pulp treatment outcomes involving calcium compounds.

PubMed ID: 23757456

Human study: topical CPP‑ACP (a calcium‑phosphate complex) improved remineralization of occlusal white‑spot lesions versus fluoride mouthrinse — direct tooth remineralization evidence.

PubMed ID: 23414245

Randomized human trial: professional application of calcium sodium phosphosilicate (NovaMin) produced large, immediate and 28‑day reductions in dentine sensitivity — strong direct dental benefit.

PubMed ID: 23712823

Direct dental trial using a calcium‑enriched material for pulp therapy with improved radiographic outcomes—strong direct dental relevance (material calcium, not systemic supplementation).

PubMed ID: 23273358

Study of CPP-ACP (contains calcium/phosphate) topical MI Paste Plus vs fluoride showed no superiority, but directly assesses calcium-containing topical remineralization for enamel/WSLs.

PubMed ID: 24685788

GC Tooth Mousse (CPP‑ACP, a calcium/phosphate technology) reduced tooth sensitivity post‑cementation—direct topical dental calcium relevance.

PubMed ID: 24299006

Clinical trial in children showed calcium hydroxide (a Ca material) is effective as a pulpotomy medicament with good 2‑year success — dental‑health relevant.

PubMed ID: 24909155

Randomized trial: calcium phosphate desensitizers (Teethmate) significantly reduced dentin hypersensitivity for up to 6 months — strong dental benefit.

PubMed ID: 24600660

β-tricalcium phosphate scaffold (Ca-containing) combined with PDGF achieved high root coverage in gingival recession—direct dental clinical benefit.

PubMed ID: 25373935

Infant formula that reduced fecal calcium loss would improve calcium retention in infants—relevant to developing teeth and enamel.

PubMed ID: 24435546

Two-year randomized split-mouth trial: calcium-enriched mixture cement achieved similar clinical/radiographic pulpotomy success—direct dental benefit from a calcium-containing material.

PubMed ID: 24856191

CPP‑ACPF (calcium/phosphate/peptide) paste raised plaque pH substantially in orthodontic patients—relevant to remineralization and dental health.

PubMed ID: 25122980

Chewing gum with calcium hydroxyapatite produced large, clinically meaningful reductions in dentin hypersensitivity.

PubMed ID: 25095313

Dental pulp capping study: calcium‑containing materials (MTA, Nano‑HA, calcium hydroxide) affected dentin bridge formation and pulp response.

PubMed ID: 25467231

In immature necrotic teeth, MTA outperformed calcium hydroxide for apical closure and had fewer fractures — directly dental and tooth‑health relevant.

PubMed ID: 25197990

Sealing deep caries led to dentin remineralization with increased calcium and phosphorus content — direct evidence of mineral (including Ca) contribution to tooth repair.

PubMed ID: 25197997

Calcium hydroxide pulpotomy success improved with NaOCl cleaning—direct evidence of a calcium compound aiding dental tissue repair.

PubMed ID: 25028689

CPP‑ACP (calcium‑phosphate) paste reduced dentin hypersensitivity and supported remineralization—direct dental calcium benefit.

PubMed ID: 24665971

Children using low‑fluoride toothpastes with calcium glycerophosphate were studied; directly relevant to topical calcium compounds and dental fluoride exposure.

PubMed ID: 25102461

Direct pediatric clinical trial comparing calcium sulfate vs standard calcium hydroxide for pulp capping—relevant to tooth healing/materials.

PubMed ID: 25224595

Caphosol (calcium‑phosphate mouthwash) was tested in chemo mucositis; directly oral/calcium chemistry even though it did not improve clinical mucositis outcomes.

PubMed ID: 24683578

Extraction site/graft study using calcium‑containing grafts informs dental bone healing and tooth-site outcomes.

PubMed ID: 25571679

CPP‑ACP (amorphous calcium phosphate) cream in children showed modest stabilization of early enamel lesions and reduced S. mutans — direct calcium‑based dental product evidence.

PubMed ID: 24771228

Five-year RCT showed calcium‑enriched cement (a calcium dental material) performed comparably to root canal therapy for mature molars — strong dental outcome evidence.

PubMed ID: 25970794

Comparison of calcium-containing dental cements for primary molar pulpotomy showed good clinical/radiographic success — relevant to dental materials containing calcium.

PubMed ID: 26159384

Calcium-containing bioactive glass pastes reduced bleaching-related tooth sensitivity in a dental RCT (topical calcium benefit to teeth).

PubMed ID: 26361810

Randomized crossover trial: calcium‑phosphate desensitizer paste markedly reduced dentin hypersensitivity vs placebo up to 6 months (topical calcium effect).

PubMed ID: 25895964

Large RCT in toddlers: CPP-ACP (a calcium/phosphate complex) markedly reduced enamel lesion area and new decay—direct, high-quality evidence linking calcium/phosphate to dental remineralization.

PubMed ID: 26723484

RCT of calcium‑based pulp‑capping materials (calcium hydroxide/tricalcium silicate) showed high short‑term success when combined with laser — direct dental benefit from calcium-containing materials.

PubMed ID: 26439386

Periodontal therapy with hydroxyapatite (calcium phosphate) improved bone supporting teeth—direct dental relevance.

PubMed ID: 26525553

MTA (a calcium‑containing dental material) produced thicker reparative dentin bridges and fewer necrosis/abscesses in pulp capping — direct clinical dental material evidence.

PubMed ID: 26418918

CPP‑ACFP (a calcium‑containing topical) produced faster remineralisation of early enamel lesions vs fluoride varnish — direct, high‑quality evidence for dental health.

PubMed ID: 26174080

Enamel matrix ± calcium phosphate graft produced similar sustained bone/attachment improvements — relevant to periodontal health and tooth support.

PubMed ID: 25951308

ACP-containing sealants performed comparably for retention and caries prevention in children—relevant topical calcium benefit for teeth.

PubMed ID: 25762499

CPP-ACP/CPP-ACFP pastes (calcium-phosphate) improved plaque pH and enamel remineralisation in Sjögren's patients—strong topical calcium evidence for teeth.

PubMed ID: 26423502

RCT: calcium hydroxide intracanal medicament produced very high root canal success—direct dental evidence.

PubMed ID: 25666010

Primary molar pulpotomy: white MTA (calcium silicate–based) superior clinically—relevant to dental mineralization/healing.

PubMed ID: 26080888

Root canal filling containing calcium hydroxide showed high success and favorable resorption—direct dental material evidence.

PubMed ID: 26031301

Human direct pulp capping with calcium hydroxide produced thicker reparative dentin—strong tooth-specific evidence.

PubMed ID: 25954828

Nd:YAG laser modified enamel chemistry and markedly reduced caries and increased microhardness (calcium-containing mineral) — directly relevant to tooth mineral integrity.

PubMed ID: 27639827

Chewing gum delivering bioavailable Ca improved enamel lesion remineralization vs placebo in an RCT — direct tooth benefit.

PubMed ID: 27891629

RCT comparing calcium hydroxide pulp capping showed clinically relevant effects on pulp survival—direct dental application of a calcium salt.

PubMed ID: 26908630

Periodontal regeneration trial using β‑TCP scaffold (calcium phosphate) showed substantial bone fill around teeth—direct dental bone/periodontal benefit.

PubMed ID: 27163717

Large RCT in children: Ca-glycerophosphate–containing toothpaste performed similarly to standard fluoride toothpaste for caries outcomes (dmfs).

PubMed ID: 28390207

CSPS (calcium‑containing bioactive glass) toothpastes reduced dentin hypersensitivity versus baseline, indicating benefit to dental health/symptoms.

PubMed ID: 26863893

Dental pulpotomy materials (calcium silicate–based) showed high clinical/radiographic success in primary molars — direct dental/biomaterial evidence.

PubMed ID: 27295867

Toothpaste containing calcium sodium phosphosilicate (CSPS) produced measurable improvements in dentin sensitivity — direct calcium‑containing dental product effect.

PubMed ID: 28169260

Direct dental RCT: calcium hydroxide pulp capping stimulated reparative dentin and high clinical success—strong direct evidence for dental mineral/tissue benefits.

PubMed ID: 27295868

Toothpaste containing calcium sodium phosphosilicate reduced dentin sensitivity—direct clinical dental benefit from a calcium‑containing material.

PubMed ID: 28045314

Monthly CPP‑ACP (calcium‑phosphate) paste significantly reduced new white‑spot lesions during orthodontic treatment—direct dental calcium‑based benefit.

PubMed ID: 27480987

CPP‑ACP (a calcium‑phosphate remineralizing agent) produced improvement in post‑orthodontic white spot lesions—direct dental calcium product evidence.

PubMed ID: 27557918

CPP‑ACP gel reduced Streptococcus mutans in preschoolers—supports a tooth‑health benefit from a calcium‑phosphate product, though not superior to placebo in that trial.

PubMed ID: 27966503

Toothpaste containing calcium sodium phosphosilicate (CSPS) reduced dentinal hypersensitivity more than comparators—clinical dental benefit of a calcium‑containing agent.

PubMed ID: 27595722

Clinical pulpotomy trial: Biodentine and MTA (calcium silicate materials) showed high success in primary teeth — directly relevant to maintaining tooth health via calcium‑containing restorative materials.

PubMed ID: 28391662

RCT of toothpaste containing calcium sodium phosphosilicate (bioactive Ca-containing) showing reduced dentin hypersensitivity — topical calcium benefit to teeth.

PubMed ID: 28917577

Pulp-capping trial in children including calcium hydroxide with comparable clinical success — direct dental relevance.

PubMed ID: 28673494

2‑year pulpotomy trial: calcium hydroxide performed worse than MTA but is directly relevant as a calcium dental material (clinical context important).

PubMed ID: 29073902

Randomized dental trial of a calcium‑hydroxide containing pulpectomy paste in primary molars showed superior radiographic/clinical success — direct dental/teeth relevance.

PubMed ID: 28581920

Calcium hydroxide and MTA (calcium‑containing) performed similarly for pulp survival and healing—direct clinical dental evidence.

PubMed ID: 28355362

At‑home whitening products labelled 'with calcium' achieved whitening with transient sensitivity—topical Ca inclusion is relevant to dental outcomes.

PubMed ID: 28678953

Topical CPP‑ACPF (Ca/phosphate + F) reduced early sensitivity after bleaching—direct benefit of a Ca‑containing agent to tooth sensitivity and integrity.

PubMed ID: 29178761

High long‑term pulpotomy success with Ca‑based materials (MTA/CEM) supports tooth vitality and radiographic outcomes.

PubMed ID: 29211128

Topical calcium added to in‑office bleaching gels reduced transient tooth sensitivity — direct dental benefit of calcium-containing product.

PubMed ID: 29069156

Single‑use whitening gel containing a calcium complex produced modest whitening and had low local adverse effects—topical calcium component.

PubMed ID: 28656922

Daily CPP‑ACFP paste produced significant enamel remineralization over 4 weeks—direct topical calcium/phosphate effect.

PubMed ID: 29070158

Partial pulpotomy with calcium hydroxide/MTA (calcium‑containing materials) produced high 24‑month success—relevant to clinical dental outcomes.

PubMed ID: 29070160

Direct clinical trial of tricalcium-silicate vs calcium-hydroxide materials for deep caries showing high clinical/radiographic success—direct dental Ca relevance.

PubMed ID: 28914245

MTA (a Ca-containing material) used in pulpotomies had similar success to comparator—small trial but relevant to tooth-preserving Ca materials.

PubMed ID: 28292338

Calcium hydroxide intracanal dressing reduced bacterial loads and achieved more complete eradication—directly relevant to endodontic tooth health.

PubMed ID: 28657702

Addition of calcium-sodium-phosphosilicate (CSPS) to fluoride dentifrice was non-inferior for enamel remineralization—supports topical Ca-containing product benefit for teeth.

PubMed ID: 30592368

Calcium‑based socket graft preserved ridge width and reduced vertical bone loss after extraction — clinically meaningful dental hard‑tissue preservation.

PubMed ID: 30232625

Calcium‑silicate cement (Biodentine™) used for indirect pulp capping maintained tooth vitality—direct dental calcium material effect.

PubMed ID: 29736496

Eating paneer (high dietary calcium) after sugar challenge raised salivary calcium and sped pH recovery—plausible caries‑protective effect.

PubMed ID: 30506227

Topical calcium‑sodium phosphosilicate (NovaMin) paste directly tested for dentin hypersensitivity; directly relevant to dental benefit.

PubMed ID: 29948282

Intracanal calcium hydroxide increased VIP (a peptide linked to bone/healing) in periapical fluid—suggests a pro-healing effect relevant to dental repair.

PubMed ID: 29520944

Topical calcium‑phosphate desensitizer before bleaching significantly reduced tooth sensitivity without impairing whitening—direct dental benefit.

PubMed ID: 29744721

MTA/Biodentine (calcium‑silicate materials) pulpotomy RCT in primary molars showed high 2‑year success—direct evidence for calcium‑containing dental materials.

PubMed ID: 30317420

Pulpotomy trial using calcium hydroxide as the pulpotomy agent—relevant to dental healing though the comparison focused on haemostasis agent.

PubMed ID: 30465358

Direct clinical use of calcium hydroxide intracanal medicament produced >90% radiographic resolution of periapical lesions—strong dental healing evidence.

PubMed ID: 30054099

Calcium hydroxide used as intracanal medicament in endodontic retreatment—clinical dental context directly relevant to tooth treatment outcomes.

PubMed ID: 29767382

TheraCal (calcium-releasing pulp-capping material) performed comparably to MTA with high 12‑month clinical/radiographic success—direct tooth-restorative evidence.

PubMed ID: 29372191

CPP‑ACP (topical calcium/phosphate) RCT in children showed clear remineralization of white‑spot lesions—direct strong evidence for dental benefit.

PubMed ID: 31317669

Calcium‑phosphate coating on dental implants produced comparable 1‑year bone stability—relevant to local calcium effects on peri‑implant bone.

PubMed ID: 30612569

Biodentine (calcium‑silicate cement) performed well as pulpotomy material—direct clinical dental benefit from a calcium‑containing biomaterial.

PubMed ID: 30804314

Topical amorphous calcium‑phosphate sealant reduced caries scores vs comparator in children—direct dental benefit from a calcium‑containing material.

PubMed ID: 31116277

Calcium hydroxide pulpotomy outcomes were inferior to MTA, but study demonstrates clinical relevance of calcium‑based dental materials.

PubMed ID: 31295393

Bleaching protocols reduced enamel calcium and phosphorus — demonstrates importance of enamel calcium to dental health (implicates protective role of calcium).

PubMed ID: 31882030

Tricalcium silicate used in pulpotomy had ≈97% long‑term clinical success—direct dental benefit from a calcium‑containing material.

PubMed ID: 31584030

CPP‑ACP varnish (calcium‑phosphate) tended to reduce S. mutans in children (non‑significant) — modest dental relevance.

PubMed ID: 31096259

Calcium hydroxide liner delivered high 12‑month pulp survival after partial caries removal — supports dental use of calcium compounds.

PubMed ID: 30804309

Calcium hydroxide and biodentine as pulp liners gave high clinical/radiographic success and increased dentin barrier thickness in primary molars (direct dental calcium material evidence).

PubMed ID: 31166415

Selective caries removal trial showed high success using calcium‑based liners (MTA, Ca hydroxide) with dentin barrier formation in primary teeth.

PubMed ID: 31300248

Calcium hydroxide was used as intracanal medicament in retreatment; study links intracanal calcium use to clinical healing context (indirect dental support).

PubMed ID: 31104819

Calcium hydroxide (a Ca compound) used as pulp capping produced clinically relevant dental outcomes (1-year success, less postop pain) — direct dental relevance.

PubMed ID: 30788777

MTA (calcium-containing) used in pediatric pulp treatments showed comparable clinical success — clinical dental calcium-material relevance.

PubMed ID: 31134470

CPP-ACP (bioavailable calcium/phosphate) produced mineral gains in early primary tooth lesions comparable to fluoride — direct topical calcium relevance.

PubMed ID: 31732883

CPP-ACP paste reduced salivary S. mutans in preschoolers — topical calcium‑phosphate product with clear dental relevance.

PubMed ID: 41552268

Trial compared calcium hydroxide (a calcium‑based intracanal medicament) to antibiotic+anti‑inflammatory paste for post‑op dental pain — direct dental application of a calcium compound.

PubMed ID: 33383182

Use of calcium hydroxide intracanal pastes reduced periapical inflammatory marker in endodontic treatment—directly dental and tooth-related.

PubMed ID: 32929721

Study of calcium‑silicate vs epoxy root canal sealers shows use of calcium‑containing materials in dentistry (relevant to tooth treatment outcomes, local not systemic).

PubMed ID: 32462277

Addition of lidocaine to calcium hydroxide intracanal medicament reduced post‑op pain after root canal — direct dental application of a calcium compound (local use).

PubMed ID: 33063220

iRoot BP Plus (a calcium‑containing bioceramic) pulpotomy had high 24‑month success in primary molars — evidence for calcium-based dental materials supporting tooth health.

PubMed ID: 32676136

Calcium‑silicate pulpotomy produced rapid postoperative pain relief comparable to RCT — supports use of calcium-containing materials in tooth preservation.

PubMed ID: 32866050

Adding functionalized tricalcium phosphate (a calcium component) to fluoride varnish significantly increased dentine caries arrest in preschool children — direct dental benefit from a calcium-containing agent.

PubMed ID: 32034789

Calcium hydroxide intracanal paste (with ciprofloxacin) improved bacterial elimination vs Ca(OH)2 alone — relevant to endodontic treatment outcomes and tooth health.

PubMed ID: 33175326

Portland cement (calcium‑containing) gave excellent pulpotomy success in primary molars — direct relevance to clinical tooth preservation using calcium-containing materials.

PubMed ID: 32096595

MTA and Biodentine (calcium‑silicate materials) effective for pulpotomy in immature teeth—directly relevant to tooth healing with calcium materials.

PubMed ID: 33098889

Study of a tricalcium‑silicate (calcium‑containing) sealer vs resin for root canal obturation—relevant to dental calcium materials and outcomes.

PubMed ID: 32348009

Pulpotomy study compared calcium hydroxide (classic calcium‑based pulp agent) and showed dental healing outcomes—direct dental calcium use.

PubMed ID: 32799365

Use of calcium‑phosphate graft preserved alveolar bone post‑extraction—supports dental structural health relevant to teeth.

PubMed ID: 31936519

Intracanal calcium hydroxide paste compared clinically to propolis—direct use of a calcium compound in endodontics.

PubMed ID: 32577707

Topical tri-calcium phosphate (fTCP) varnish produced large, clinically significant reversal of orthodontic white-spot lesions vs control—direct dental benefit of a calcium-containing agent.

PubMed ID: 32829540

Intracanal calcium hydroxide + dexamethasone significantly reduced post‑endodontic pain vs placebo—direct, clinically meaningful use of a calcium-based dental medicament.

PubMed ID: 32876119

Calcium-silicate cement performed equivalently to MTA in primary molar pulpotomy with less discoloration—relevant to dental material outcomes.

PubMed ID: 31969547

Nanoseal application suppressed root‑caries progression — directly relevant to preserving tooth structure (clinical dental outcome).

PubMed ID: 32984080

Probiotic increased salivary calcium and improved plaque/gingival measures — plausible local benefit to tooth health via raised salivary Ca.

PubMed ID: 33402624

Dental trial found indirect pulp treatment with calcium hydroxide achieved clinical/radiographic success comparable to alternative therapy—direct dental clinical use of a calcium compound.

PubMed ID: 32356211

Fluoride varnish with tricalcium phosphate produced larger, longer reductions in cariogenic bacteria in children — direct, high‑relevance calcium‑containing dental product evidence.

PubMed ID: 32914509

Pulpotomy with calcium‑silicate (Biodentine) produced greater and lasting reduction in tooth sensitivity — direct clinical benefit from a calcium‑based dental material.

PubMed ID: 33439563

Randomized split‑mouth trial: calcium‑phosphate desensitizer significantly reduced dentin hypersensitivity up to 6 months.

PubMed ID: 34856212

Calcium‑silicate sealer obturation showed similar success/pain outcomes to conventional techniques—relevant to endodontic tooth health.

PubMed ID: 34201328

MTA + bone graft gave best radiographic defect fill in endo‑periodontal lesions—benefits tooth support structures.

PubMed ID: 34854987

Full pulpotomy with calcium‑based materials yielded clinical/radiographic outcomes comparable to RCT—supports tooth vitality preservation.

PubMed ID: 34192759

In young permanent molars, calcium‑containing pulp‑capping materials (TheraCal/Biodentine) outperformed Dycal—direct dental benefit.

PubMed ID: 34639351

Topical fluoride + calcium-phosphate varnishes appeared to halt new cavities in high-caries-risk children—direct oral/dental calcium-containing product benefit.

PubMed ID: 33543449

Calcium hydroxide used as a pulp-capping agent showed numerically higher clinical/radiographic success in primary molars—direct dental calcium application evidence.

PubMed ID: 34657018

Partial pulpotomy in immature permanent molars (including calcium hydroxide) produced high clinical success and root development—directly relevant to dental tissue outcomes.

PubMed ID: 34555421

Use of calcium hydroxide intracanal medication studied; outcomes included periapical healing—direct dental relevance.

PubMed ID: 33404764

Direct dental trial: calcium hydroxide/Biodentine (calcium-based) had excellent clinical/radiographic success for indirect pulp capping in primary teeth—strong direct evidence for calcium-containing dental materials.

PubMed ID: 33507394

Study included calcium-containing restorative materials (Biodentine, MTA) and compared dentin-bridge outcomes — relevant to tooth healing/remodeling with calcium-containing materials.

PubMed ID: 34352792

Topical CPP-ACP (calcium‑phosphate complex) + fluoride produced faster remineralization of root caries vs fluoride alone—direct calcium-phosphate dental benefit.

PubMed ID: 33544983

Calcium lactate + fluoride mouthrinse prevented bleaching-related sensitivity vs control—topical calcium application reduced sensitivity.

PubMed ID: 34821978

CPP-ACP/CPP-ACPF pastes increased remineralization in MIH children, showing topical calcium-phosphate benefit for tooth structure.

PubMed ID: 33683572

Calcium‑silicate dental materials (Biodentine/MTA) gave very high pulpotomy success — directly relevant to dental tissue repair.

PubMed ID: 33662244

Topical calcium‑phosphate‑containing fluoride varnish (CPP‑ACP‑F) produced superior remineralization of white‑spot lesions vs standard fluoride varnish — direct calcium‑based dental benefit.

PubMed ID: 33483869

Premixed bioceramic (calcium‑based) repair material outperformed MTA for primary molar furcal perforation—direct clinical benefit for tooth integrity in children.

PubMed ID: 33907070

Neither ultrasonic nor rotary methods completely removed oil‑based calcium hydroxide from root canals—study directly concerns a calcium‑containing endodontic medicament and clinical outcomes.

PubMed ID: 34331070

Bioluminescence method detected enamel demineralization (calcium release) near brackets—directly measures tooth mineral (calcium) loss relevant to dental health.

PubMed ID: 33719478

MTA vs Biodentine pulpotomy in immature permanent molars (both calcium‑based) showed high success—direct dental‑health evidence in growing teeth.

PubMed ID: 34018341

Nano‑hydroxyapatite application reduced bleaching sensitivity and supports enamel remineralization (topical calcium phosphate effect).

PubMed ID: 35191065

Guided bone regeneration RCT using calcium‑phosphate graft materials—directly relevant to dental hard‑tissue support around implants (tooth/implant support).

PubMed ID: 35419985

Aragonite (calcium carbonate) toothpaste reduced calculus and gingival inflammation vs control — direct topical calcium‑based dental benefit.

PubMed ID: 35152464

Pulpotomy with calcium‑silicate materials had high 1‑year clinical/radiographic success — relevant to tooth health using calcium‑containing biomaterials.

PubMed ID: 35748451

Calcium hydroxide as an indirect pulp capping agent showed high clinical/radiographic success in primary molars — direct dental benefit.

PubMed ID: 36947754

Direct pulp capping in primary molars using calcium hydroxide had high success — clinical dental benefit in children.

PubMed ID: 36445467

Calcium‑silicate cements caused tooth discoloration — directly relevant to dental outcomes (neutral/negative effect to consider).

PubMed ID: 36460919

Use of calcium-silicate liner with selective caries removal preserved pulp vitality and reduced exposures—direct tooth-preserving effect.

PubMed ID: 36494113

Bioactive glass (BiominF) produced large, quantifiable remineralization of white-spot lesions—strong dental benefit mediated by calcium/phosphate release.

PubMed ID: 36322154

Topical calcium/phosphate tooth cream (f‑TCP, CPP‑ACP) produced meaningful remineralization of white‑spot lesions vs no treatment—direct dental benefit.

PubMed ID: 35830636

In children with hypomineralised incisors, calcium‑containing remineralizing agents improved lesions over 3 months (though not superior to fluoride toothpaste).

PubMed ID: 35075598

MTA (a calcium‑containing material) partial pulpotomy in primary molars achieved high clinical success—direct dental application of calcium materials.

PubMed ID: 35799339

Direct dental application of calcium hydroxide for pulp capping showed high clinical/radiographic success — local calcium product benefit for teeth.

PubMed ID: 35869721

Randomized trial: calcium-enriched materials (CEM/MTA) for immature permanent molars reduced periapical lesions vs RCT — strong topical calcium benefit for dental outcomes.

PubMed ID: 34679162

Topical calcium‑phosphate varnish gave modest protection against enamel white-spot lesions in adolescents — direct dental calcium effect.

PubMed ID: 35815478

Randomized 2‑year trial: tricalcium silicate paste (a calcium‑containing remineralizing agent) produced significant long‑term enamel remineralization—strong direct evidence for a calcium material benefit to teeth.

PubMed ID: 36507748

Primary molar trial compared restorations with/without calcium‑hydroxide lining; outcomes directly inform use of calcium‑based dental materials.

PubMed ID: 34856038

Pulpectomy trial: iodoform paste non‑inferior to calcium‑hydroxide/iodoform paste — direct relevance to calcium‑containing endodontic materials.

PubMed ID: 35311975

RCT in children: topical CPP‑ACP (calcium–phosphate) reduced white‑spot lesions and improved color — strong direct evidence for dental health.

PubMed ID: 37660882

Clinical trial of calcium‑silicate cements for pulpotomy in primary molars showed similar success to MTA — direct dental (tooth) health applicability of calcium‑based materials.

PubMed ID: 36833788

Calcium hydroxide used as intracanal medicament produced intermediate postoperative pain reduction — dental application of Ca(OH)2 relevant to tooth outcomes.

PubMed ID: 38219032

RCT comparing pulp capping materials showed calcium hydroxide had lower long‑term success — directly dental and calcium‑material relevant.

PubMed ID: 37759198

Hydroxyapatite (calcium‑phosphate) powder‑jet deposition reduced dentin hypersensitivity comparably to a calcium‑phosphate desensitizer over 12 weeks.

PubMed ID: 36049047

Topical calcium‑fluoride nanoparticle primer reduced enamel demineralization and early S. mutans colonization during orthodontic treatment.

PubMed ID: 37452640

Calcium‑silicate dental material (releasing calcium) produced similar pulpotomy success to MTA — relevant to tooth pulp preservation/remodeling.

PubMed ID: 37124935

TheraCal vs MTA (both calcium‑releasing) showed similarly high 12‑month pulpotomy success in primary molars.

PubMed ID: 37460903

Partial pulpotomy using calcium‑based capping agents showed high clinical/radiographic success (direct dental relevance).

PubMed ID: 37831601

Topical NaF varnishes combined with calcium‑phosphate agents (CPP‑ACP/TCP) produced measurable remineralization in children—strong localized calcium relevance.

PubMed ID: 37890417

Topical TiF4/NaF rinse reduced enamel Ca2+ loss during an acid challenge — direct, high‑relevance protective effect on dental mineral (calcium) loss.

PubMed ID: 37225036

Regenerative endodontic treatment using calcium hydroxide (a calcium compound) produced high survival/success in immature teeth—direct dental benefit.

PubMed ID: 37282413

Children's toothpaste containing tricalcium phosphate reduced Streptococcus mutans counts—topical calcium compound linked to oral health.

PubMed ID: 38701294

RCT comparing two calcium‑silicate pulp‑capping materials: similar success but resin‑modified calcium product reduced postoperative pain and procedure time — direct clinical dental evidence.

PubMed ID: 39442480

Randomized trial using a calcium‑silicate (Biodentine) pulp‑capping material showed much higher pulp preservation vs selective caries removal — direct dental benefit from a calcium‑based material.

PubMed ID: 39655615

Four‑year evaluation found calcium‑silicate root‑canal sealer performed at least as well as ZOE for periapical healing — supports dental tissue healing with calcium‑based material.

PubMed ID: 39384060

RCT of calcium‑containing bioactive dental cements in primary molars showed high 1‑yr clinical/radiographic success—direct relevance to calcium‑based dental materials and tooth health.

PubMed ID: 40079993

Trial comparing tricalcium silicate pulp capping vs RMGIC—calcium‑containing material performed acceptably (relevant to tooth vitality).

PubMed ID: 39862396

Dentin‑bridge formation study: both Biodentine and Ca(OH)2 effective; demonstrates calcium compound benefit for pulp repair/tooth integrity.

PubMed ID: 39690774

Calcium‑silicate material and calcium hydroxide were used for partial pulpotomy in immature teeth with good 3‑year outcomes—direct dental application of calcium compounds.

PubMed ID: 38430316

Endodontic root‑end filling materials containing calcium compounds produced high 1‑year clinical success—relevant to dental health and calcium‑based materials.

PubMed ID: 38849655

Intracanal calcium hydroxide used as a medicament; outcomes similar to comparators—directly dental but not superior.

PubMed ID: 39798105

Indirect pulp therapy trial found calcium hydroxide comparable to other materials for molar success—supports dental uses of calcium compounds.

PubMed ID: 38488954

Calcium‑enriched cement used for pulpotomy in primary molars produced high clinical/radiographic success — direct dental Ca material benefit.

PubMed ID: 38281619

Bioceramic (calcium silicate) pulp dressing performed similarly to MTA in pulpotomy — relevant to local Ca materials and tooth preservation.

PubMed ID: 38316823

Randomized pulpotomy trial: calcium‑silicate cement performed well with high success and calcific bridge formation — direct dental benefit from calcium‑based material.

PubMed ID: 38297465

Primary molar partial pulpotomy: calcium‑based materials (MTA/biodentine) had high mid‑term success — clear dental health relevance.

PubMed ID: 39316130

CPP-ACP (calcium‑phosphate) improved early enamel lesion measures in patients — strong, direct evidence for topical calcium‑based dental benefit.

PubMed ID: 38956853

Light‑cured calcium silicate liner produced more new dentin vs MTA/Dycal in children — direct calcium‑material benefit for tooth repair.

PubMed ID: 39352296

Pulpotomy trials used MTA (calcium‑containing) with high success rates — clinically relevant to tooth vitality and calcium materials.

PubMed ID: 38357755

Two remineralizing toothpastes (one with calcium sodium phosphosilicate or hydroxyapatite) reduced sensitivity and improved enamel/periodontal measures over 6 months.

PubMed ID: 38180467

Indirect pulp‑capping protocols, some using calcium liners, produced similarly high tooth vitality — relevant to calcium dental materials.

PubMed ID: 39641370

Bioceramic calcium‑silicate cements gave high pulpotomy success in primary molars over 24 months — strong local tooth health evidence for calcium materials.

PubMed ID: 39186604

Denture adhesives containing calcium salts (Ca/Zn) markedly reduced food particle ingress beneath partial dentures — direct, clinically relevant dental benefit from a calcium‑containing formulation.

PubMed ID: 38616424

Calcium hydroxide + zinc oxide used as an obturating material in children's pulpectomy produced similar high clinical/radiographic success — direct dental use of a calcium compound.

PubMed ID: 38834143

Platelet concentrate activated with calcium chloride improved radiographic bone formation in extraction sockets — local calcium activation improved oral bone healing and thus dental outcomes.

PubMed ID: 38233156

CPP-ACP (topical amorphous calcium phosphate) during orthodontics altered archwire corrosion and deposits and is a calcium-based topical dental agent.

PubMed ID: 40234535

RCT comparing MTA (calcium‑containing dental material) and PRF+MTA found more dentin bridge formation with PRF+MTA — direct dental (tooth hard tissue) relevance.

PubMed ID: 40586470

Pulpotomy study used eggshell‑derived nano‑hydroxyapatite (a calcium phosphate material) with good clinical/radiographic success — directly relevant to tooth repair materials.

PubMed ID: 40835176

Endodontic study showed calcium hydroxide intracanal medicament effects — directly concerns a calcium compound used in dental therapy.

PubMed ID: 40335196

Topical nano‑CaF2 (calcium fluoride) plus ammonium fluoride significantly improved remineralization and regression of white‑spot lesions vs control.

PubMed ID: 41091662

Tricalcium phosphate (TCP) varnish was one of the tested dental products and reduced bacterial counts and improved gingival scores (topical calcium relevance).

PubMed ID: 41026563

Biodentine (a calcium silicate material) outperformed comparator for indirect pulp therapy in primary molars—direct calcium‑based dental material benefit.

PubMed ID: 40550352

Toothpastes containing calcium‑phosphate‑silicate (bioactive glass) reduced dentin sensitivity and improved outcomes versus NaF varnish (topical Ca‑containing material).

PubMed ID: 40635035

Study compared simvastatin to calcium hydroxide as intracanal medicament; CH had measurable clinical/microbiological effects (calcium compound relevance).

PubMed ID: 40150951

Calcium hydroxide intracanal medicament reduced bacterial loads and was associated with regenerative treatment success (procedure‑specific calcium benefit).

PubMed ID: 40495427

Biodentine and MTA (calcium‑containing materials) showed very high clinical/radiographic success as pulp‑capping agents in primary molars — direct dental outcome.

PubMed ID: 41345947

Calcium‑silicate cements (MTA, Biodentine, BC RRM) produced favorable histologic healing and dentin‑bridge formation after pulpotomy — direct tooth‑health/repair evidence.

PubMed ID: 40155539

Calcium hydroxide and calcium‑silicate intracanal dressings reduced inflammatory and bone‑resorption mediators in periapical lesions — supports endodontic healing and tooth health.

PubMed ID: 40106002

CPP‑ACPF varnish (contains calcium) produced the largest and most sustained reductions in S. mutans and plaque in children — directly relevant to dental health/prevention.

PubMed ID: 40604659

Adjunct NaOCl gel + MTA (calcium silicate) improved early pulp healing and dentin bridge formation in primary teeth — clinically relevant for tooth preservation.

PubMed ID: 40830200

Nano‑hydroxyapatite and CPP‑ACP substantially improved enamel remineralization — strong topical dental mineralization evidence.

PubMed ID: 41272686

Intracanal calcium‑based dressings reduced bacterial/Candida levels; Ca(OH)2 had superior bacterial reduction.

PubMed ID: 40251520

Topical bioactive resin with calcium/phosphate produced large durable dentin hypersensitivity relief.

PubMed ID: 40604730

Calcium‑phosphate mouth rinse (Caphosol) during chemo reduced severe oral symptoms—oral health benefit.

PubMed ID: 41029033

Split‑mouth trial found MTA (calcium silicate) comparable to grape seed extract for primary teeth success.

PubMed ID: 40691703

Bioceramic apical plug improved periapical bone density and clinical healing—supports tooth preservation.

PubMed ID: 40288576

Direct pulp capping success varied by age with bioceramic (Ca‑containing) materials—dental outcome relevance.

PubMed ID: 40603366

Root canal protocol RCT (procedural healing) relevant to tooth survival; uses Ca‑based materials in practice.

PubMed ID: 41321289

Calcium‑hydroxide intracanal dressing (with NaOCl) markedly lowered intracanal bacteria—direct endodontic benefit.

PubMed ID: 40457274

ACTIVA bioactive (calcium‑releasing) liner increased mineralization markers compared with MTA in primary‑tooth pulpotomies—direct dental mineralization effect.

PubMed ID: 41369796

Calcium‑releasing prophy paste reduced dentin hypersensitivity immediately and up to 6 months—direct topical calcium dental benefit.

PubMed ID: 41412271

Pchi‑ACP scaffold (amorphous calcium phosphate) substantially remineralized early enamel lesions over 12 months—strong direct evidence for dental benefit.

PubMed ID: 41685840

Clinical trial of a calcium-silicate pulp-capping material showing high 1-yr pulp survival and integrity—direct dental clinical benefit of a Ca-containing material.

PubMed ID: 39856505

Periodontal intrabony-defect trial using calcium phosphate cement (a Ca material) plus growth factors improved clinical/radiographic outcomes—relevant to dental hard tissue support.

PubMed ID: 11556510

Pulpotomies dressed with calcium hydroxide showed high short-term healing rates—direct evidence for a calcium-containing dental material aiding tooth healing.

PubMed ID: 12572637

Dicalcium phosphate-based fluoride dentifrice (with xylitol) produced ~>10% reduction in caries increment in schoolchildren → directly relevant to dental health.

PubMed ID: 15287544

Calcium hydroxide paste pH and stability (endodontic medicaments) supports intracanal alkalinity and antimicrobial activity—directly relevant to dental health (topical calcium compound).

PubMed ID: 18446025

Large RCT: CPP-ACP gum reduced approximal caries progression over 24 months (strong direct evidence).

PubMed ID: 20409203

Clinical study in primary molars: a calcium‑containing root filling (Vitapex) had high short‑term clinical success — direct dental application of a calcium material supporting tooth outcomes.

PubMed ID: 28914246

Chewing gum with CPP‑ACP increased salivary flow, pH and buffering capacity in children — acute physiochemical dental benefits tied to a calcium‑containing complex.

PubMed ID: 26264630

Randomized trial where calcium hydroxide (a calcium dental material) was comparator for pulpotomy success — directly dental.

PubMed ID: 18500152

Randomized trial: arginine-bicarbonate-calcium carbonate mint produced very large, clinically meaningful reductions in new/progressing caries in children—direct calcium-containing product evidence.

PubMed ID: 19831165

8% arginine/calcium carbonate toothpaste produced large immediate and 3-day reductions in dentin hypersensitivity vs control—direct, robust evidence for a Ca-containing oral product.

PubMed ID: 19831164

Randomized double-blind trial showing significant immediate and 3-day relief of tooth sensitivity with arginine + calcium carbonate toothpaste.

PubMed ID: 19472556

In-office paste with arginine + calcium carbonate produced large immediate and 4-week reductions in dentin sensitivity versus control—direct dental benefit from a Ca-containing product.

PubMed ID: 19831167

8-week RCT: arginine/calcium carbonate toothpaste reduced tooth sensitivity more than a potassium-based paste—direct evidence for Ca-containing dentifrice benefits.

PubMed ID: 19489188

8‑week RCT showing arginine + calcium carbonate toothpaste produced significantly greater sensitivity relief vs potassium.

PubMed ID: 19489187

Canadian 8‑week RCT with clinically relevant sensitivity reductions for the calcium carbonate–based formulation.

PubMed ID: 19472557

Randomized, double‑blind in‑office study showing marked immediate desensitizing benefit of an 8% arginine + CaCO3 paste.

PubMed ID: 20669816

Head‑to‑head trial: both strontium and arginine/CaCO3 reduced sensitivity; modest evidence supporting Ca-containing formulation's efficacy.

PubMed ID: 21284250

Whitening dentifrice with arginine + high‑cleaning CaCO3 removed more surface stain vs control — benefit to extrinsic tooth appearance and cleaning.

PubMed ID: 21284248

Large randomized 3‑arm study demonstrating immediate and 3‑day reductions in dentin sensitivity for arginine + calcium carbonate formulations.

PubMed ID: 21284249

Well-powered RCT showing large, consistent dentin sensitivity reductions from an arginine + CaCO3 toothpaste.

PubMed ID: 22403989

Brushing with arginine + calcium toothpaste reduced sensitivity more than a strontium formulation and improved sensitivity on switch‑over.

PubMed ID: 22403987

Large randomized trial showing arginine + CaCO3 reduced sensitivity vs negative control and vs a strontium toothpaste (abstract-level data).

PubMed ID: 22403988

Randomized clinical trial demonstrating arginine + CaCO3 superiority vs comparators over 8 weeks (effect sizes not in abstract).

PubMed ID: 22263329

Trial where a stannous fluoride toothpaste reduced sensitivity more than arginine + CaCO3; still confirms arginine + Ca product is an active comparator but with lesser effect in that study.

PubMed ID: 21702324

Stannous fluoride outperformed arginine + Ca in short‑term relief — trial informs comparative performance but involves calcium only as part of the tested formulation.

PubMed ID: 23140517

Split‑mouth RCT: single in‑office arginine + Ca paste gave faster/longer lasting relief than calcium alone (supports combined formulation efficacy).

PubMed ID: 22988684

Professional in‑office arginine+calcium plus at‑home maintenance produced sustained sensitivity relief through 24 weeks.

PubMed ID: 23160037

3‑day trial: both desensitising pastes reduced sensitivity immediately and at Day 3; arginine/Ca was slightly favored on an evaporative measure.

PubMed ID: 22988687

Single pre‑prophylaxis application of 8% arginine + CaCO3 produced large immediate reduction in dentin sensitivity.

PubMed ID: 23380274

120‑subject RCT: arginine+calcium carbonate regimen reduced dentin sensitivity faster and more than a potassium regimen (products had multiple actives but calcium present).

PubMed ID: 23489232

85‑subject trial: arginine+CaCO3 dentifrice achieved clinically meaningful dentin hypersensitivity reductions within 3 days comparable to other effective pastes.

PubMed ID: 23985435

Large pediatric RCT showing ≈51% reduction in lesion volume at 6 months with arginine+insoluble calcium+fluoride — strong evidence for enamel/caries benefit.

PubMed ID: 23988908

Large (n≈6000), 2‑year RCT showing arginine+insoluble calcium dentifrices reduced new caries vs fluoride alone — strong clinical evidence for tooth health.

PubMed ID: 24156139

Short randomized human trial: arginine+calcium toothpaste increased plaque pH and ammonia, reducing cariogenic potential (mechanistic evidence supporting tooth health).

PubMed ID: 23985437

253‑subject adult trial: arginine+insoluble calcium+fluoride arrested/reversed more active root caries lesions than fluoride alone.

PubMed ID: 24156136

Large trial showing substantial reductions in early cavities with an arginine+insoluble calcium+fluoride toothpaste vs controls.

PubMed ID: 24156137

412 older adults: arginine + insoluble calcium + fluoride toothpaste arrested/reversed root caries better than fluoride alone — clinically meaningful.

PubMed ID: 23229241

36‑subject randomized clinical + SEM study: 8% arginine–calcium carbonate paste reduced root sensitivity and produced dentinal tubule occlusion vs fluoride gel.

PubMed ID: 23985436

331‑child trial: arginine+insoluble calcium+fluoride toothpaste produced larger decreases in early enamel lesion size vs fluoride alone.

PubMed ID: 24073527

In‑office arginine + CaCO3 paste reduced post‑prophy dentin sensitivity significantly vs control.

PubMed ID: 24156204

100‑subject RCT: 8% arginine–calcium carbonate toothpaste reduced dentin hypersensitivity vs fluoride control — clinically significant desensitization.

PubMed ID: 24156206

86‑subject RCT: arginine+calcium carbonate dentifrice improved tactile, evaporative and VAS sensitivity measures significantly vs control.

PubMed ID: 25269991

Single professional application of arginine–calcium carbonate paste produced large, sustained relief from tooth sensitivity (~6 weeks) in an RCT.

PubMed ID: 25000668

Small randomized study: arginine+insoluble calcium dentifrice raised plaque pH and ammonia and lowered lactic acid vs standard fluoride paste — mechanistic evidence reducing cariogenic challenge.

PubMed ID: 24933799

30‑adult crossover: dentifrice with arginine+calcium+fluoride produced greater enamel remineralization than fluoride-only paste (multi‑ingredient but direct remineralization shown).

PubMed ID: 26054185

Large 2‑year pediatric trial showing DMFT/DMFS reductions with dentifrices containing an insoluble calcium compound — solid population evidence (multi‑ingredient product).

PubMed ID: 26211687

RCT: ProArgin paste (arginine formulation) produced greater and longer-lasting reduction in dentin hypersensitivity than NovaMin (calcium-containing) over 30 days — clinical dentin benefit context involving calcium-containing comparators.

PubMed ID: 25864242

Randomized double-blind study: in-office plus at-home arginine+calcium carbonate system gave faster and larger dentin sensitivity relief vs potassium nitrate toothpaste over 8 weeks; calcium carbonate is a core active.

PubMed ID: 26660591

Moderate RCT in periodontitis patients: 8% arginine+CaCO3 prophylaxis paste + toothpaste prevented and reduced post-periodontal-treatment dentin/root sensitivity for 17 weeks.

PubMed ID: 28219674

Exploratory randomized trial: both 5% CSPS (calcium-releasing) and 8% arginine–CaCO3 toothpastes produced clinically meaningful dentin sensitivity relief over 11 weeks.

PubMed ID: 29520816

Pilot RCT: arginine–calcium carbonate control reduced dentin sensitivity; supports clinical efficacy of CaCO3-containing dentifrice (small study).

PubMed ID: 30074006

Iontophoresis + 8% arginine–CaCO3 produced greater and faster dentin sensitivity reductions than toothpaste alone — supports calcium-containing product effectiveness.

PubMed ID: 31150729

RCT comparing 3.14% potassium oxalate strip vs 8% arginine–CaCO3 toothpaste: both reduced dentin sensitivity; arginine–CaCO3 served as active comparator — supports CaCO3 dentifrice activity.

PubMed ID: 31233629

Randomized clinical trial: 5% fluorocalcium-phosphosilicate toothpaste (calcium-containing) reduced dentin sensitivity more than arginine–CaCO3 and placebo.

PubMed ID: 30710652

Large multicenter RCT: in-office + at-home 8% arginine–CaCO3 produced substantial, sustained reductions in dentin hypersensitivity — strong clinical evidence for dental benefit of calcium-containing technology.

PubMed ID: 30968066

Well-sized RCT: calcium-containing CSPS dentifrice produced clinically meaningful reductions in dentin hypersensitivity similar to arginine–CaCO3.

PubMed ID: 32497553

Large randomized double-blind trial: calcium-silicate toothpaste reduced dentin sensitivity vs fluoride control across multiple measures.

PubMed ID: 33025927

Small RCT: phosphate-based (remineralizing) toothpaste produced large immediate and 1-week reductions in dentin hypersensitivity — supports remineralizing (calcium/phosphate) approaches.

PubMed ID: 34061357

RCT in post-periodontal therapy patients: CSPS (bioactive glass, calcium-containing) toothpaste produced rapid and sustained reductions in root/dentin sensitivity.

PubMed ID: 34615511

Large triple-blind RCT showing fluoro-calcium-phosphosilicate and other calcium-containing dentifrices gave large immediate and 6-week reductions in dentin hypersensitivity.

PubMed ID: 37002263

Randomized clinical trial: tricalcium‑phosphate toothpaste produced large reductions in dentin sensitivity versus control.

PubMed ID: 39810073

Large randomized trial: CPP‑ACP and other calcium‑based toothpastes markedly reduced dentin sensitivity and improved oral QoL.

PubMed ID: 1910254

Population data showing inadequate calcium intake—relevant to tooth mineralization and dental health.

PubMed ID: 1756217

Fluoride varnishes containing calcium fluoride reduced caries ~25–30% in children; calcium fluoride was an ingredient but fluoride is main active.

PubMed ID: 1435827

Infant milk study documented high intestinal calcium absorption and normal bone mineralisation—supports mineral availability relevant to dental development in infants.

PubMed ID: 8402801

Topical calcium lactate toothpaste significantly reduced dental calculus formation over 3 months — direct dental benefit.

PubMed ID: 8624228

Toothpaste containing calcium hydrogen phosphate reduced gingival inflammation and bleeding (~40%), showing a topical calcium‑containing product benefit for oral health.

PubMed ID: 8997677

Calcium carbonate implant used in periodontal regeneration produced clinical periodontal improvements—direct relevance to dental/bone health in the mouth.

PubMed ID: 9028183

Stepwise caries excavation using calcium hydroxide halved pulp exposure rates vs full excavation—direct dental benefit from a calcium compound.

PubMed ID: 8897531

Direct dental trial: calcium‑hydroxide pulp medicament produced similar short‑term clinical/radiographic success to ZOE in primary molars (use of a Ca compound in dentistry).

PubMed ID: 9641128

Dental trial comparing pulp capping methods used calcium hydroxide as the control — directly relevant to dental use of a calcium compound.

PubMed ID: 10687503

Randomized trial: remineralizing toothpaste delivering soluble calcium reduced root‑caries progression in high‑risk patients.

PubMed ID: 10649920

Dentifrices with precipitated calcium carbonate base reduced extrinsic stain vs fluoride paste — direct, product-level evidence for a calcium-containing dental preparation.

PubMed ID: 10972349

Study of preterm infants found very high enamel defect rates and that mineral/Vit D supplementation did not reduce defects — directly relevant to dental outcomes.

PubMed ID: 10710462

In vitro endodontic study showed denser calcium hydroxide canal fills—direct relevance to dental use of a calcium compound.

PubMed ID: 10697342

Clinical trial comparing calcium hydroxide (a calcium compound) for primary molar pulp therapy showed acceptable success (77%), supporting dental applications of calcium compounds.

PubMed ID: 11218508

Natural coral‑calcium bone graft significantly improved periodontal pocket depth, attachment level, and reduced tooth mobility — strong direct dental benefit.

PubMed ID: 11690570

Randomized trial: calcium plus vitamin D reduced tooth loss in older adults (clinically meaningful outcome).

PubMed ID: 11481926

Large trial in children where a dentifrice containing dicalcium phosphate dihydrate plus fluoride reduced caries incidence ≈14% vs fluoride-only — direct dental benefit from a calcium-containing preparation.

PubMed ID: 11808763

CPP-ACP containing gum produced large, dose-dependent increases in enamel remineralization — direct, high-quality evidence for a calcium-containing product benefiting teeth.

PubMed ID: 11481927

Large RCT: toothpaste with dicalcium phosphate plus fluoride produced ~11% lower 2-year caries increment vs fluoride-only—direct calcium-containing product benefit for teeth.

PubMed ID: 11858203

Intracanal calcium hydroxide markedly reduced root-canal bacterial counts — direct dental benefit.

PubMed ID: 12218280

Large RCT of fluoride toothpaste containing a calcium compound showed substantial reduction in new caries in children.

PubMed ID: 12064499

Calcium hydroxide liner evaluated in primary molars — direct dental application of a calcium compound with tooth outcomes.

PubMed ID: 11925535

Randomized trial of a casein‑derivative/calcium‑phosphate oral system vs fluoride in dry‑mouth patients — directly tests Ca‑containing dental product and caries outcomes.

PubMed ID: 12887380

MTA (a calcium‑containing dental material) showed high healing rates in root‑end surgery — direct dental relevance (material, not supplement).

PubMed ID: 14600695

Direct pulp capping with calcium hydroxide induced significantly more hard‑tissue bridge formation than adhesive — strong direct dental tissue‑forming benefit.

PubMed ID: 14531593

Topical amorphous calcium phosphate produced a clear, rapid clinical reduction in dentin hypersensitivity vs placebo — direct, high‑relevance dental benefit.

PubMed ID: 12974867

Calcium hydroxide formulations produced higher dentine surface pH / hydroxyl release—directly relevant to dental healing/antimicrobial action.

PubMed ID: 14732982

Calcium hydroxide (a calcium compound) produced apexification and healing comparable to demineralized dentin matrix—clinical dental calcium use.

PubMed ID: 15295946

Study specifically measured mandibular bone mass with calcium + vitamin D in postmenopausal women—direct oral/jaw bone relevance.

PubMed ID: 15688962

Topical baking‑soda dentifrice containing calcium and phosphate reduced extrinsic tooth stain vs control—direct dental benefit (local calcium application).

PubMed ID: 15645905

Randomized clinical data: fluoride toothpaste containing calcium and phosphate produced marked improvements in enamel gloss and smoothness over 3 months (direct product evidence).

PubMed ID: 15089940

Small RCT: topical calcium-hydroxide suspension after crown prep reduced dentinal sensitivity versus baseline — direct dental application evidence.

PubMed ID: 15525310

Vitapex (calcium hydroxide paste) in primary teeth produced superior clinical/radiographic success—direct dental (tooth) benefit.

PubMed ID: 15645907

Dual‑phase dentifrice containing calcium/phosphate reduced lingual calculus by ~16% vs control; direct topical calcium relevance to dental health.

PubMed ID: 15472665

Calcium hydroxide intracanal medication reduced postoperative endodontic flare-ups — relevant to tooth health and endodontic outcomes.

PubMed ID: 15910477

Calcium hydroxide lining in restorations protected pulp comparably to adhesive conditioning for up to 36 months.

PubMed ID: 15998785

Higher dietary calcium status that preserves bone mineral may also support dental mineral health.

PubMed ID: 19185400

Calcium (1,200 mg) + vitamin D3 trial in elderly women improved 25(OH)D and lowered PTH — supports bone/metabolic aspects of healthy aging.

PubMed ID: 11329114

RCT in older/postmenopausal women: calcium citrate prevented spine/radial bone loss—relevant to preserving musculoskeletal health with aging.

PubMed ID: 9692071

Postmenopausal Ca+D trial showed modest spine BMD gain — relevant to healthy aging bone maintenance.

PubMed ID: 9718191

Vitamin D (and UV-B) raised 25(OH)D, increased serum calcium and lowered PTH in very elderly subjects — indirectly supports calcium homeostasis important in aging.

PubMed ID: 9564795

Oral calcium 1000 mg/day prevented lumbar-spine bone loss in steroid-treated adults over 18 months — supports skeletal preservation relevant to healthy aging.

PubMed ID: 9625104

1200 mg/day calcium lowered bone resorption markers in postmenopausal women, a mechanism relevant to healthy aging bone maintenance.

PubMed ID: 9797910

Large RCT in early postmenopausal women (Ca+vitamin D) increased lumbar spine BMD — relevant to skeletal health in aging.

PubMed ID: 9102058

Long-term calcium supplementation in elderly women reduced hip/ankle bone loss over 4 years, a meaningful benefit for healthy musculoskeletal aging.

PubMed ID: 9388377

Elderly osteoporotic patients receiving active vitamin D plus calcium had improved BMD and fewer vertebral fractures — supports aging-related bone health.

PubMed ID: 9278463

Large RCT in older adults showing Ca+D slowed bone loss and fewer nonvertebral fractures—relevant to healthy aging via skeletal preservation.

PubMed ID: 8704358

In corticosteroid patients, Ca (1 g) + monofluorophosphate markedly increased lumbar BMD — relevant to skeletal health in aging (combined product, not Ca alone).

PubMed ID: 8923359

Women on steroids: calcitonin+calcium preserved/increased hip BMD while calcium alone showed loss — relevant to bone health in older/adult populations.

PubMed ID: 8883119

Osteoporotic women: calcium (500 mg/day) used as comparator; combined therapy preserved/increased BMD vs calcium alone — supports role of calcium in aging bone health.

PubMed ID: 9026268

2-yr trial with calcium given to all: active vitamin D + calcium increased lumbar BMD vs placebo, implying calcium contributes to bone health in older adults.

PubMed ID: 8794428

RCT in postmenopausal women: 1 g/day calcium largely prevented 1-year bone loss—relevant to healthy aging bone preservation.

PubMed ID: 8781044

Early postmenopausal women: high-calcium mineral water reduced radius bone loss and lowered osteocalcin vs low-calcium water.

PubMed ID: 8661952

Randomized trial in elderly women: oyster-shell/seaweed calcium improved lumbar-spine BMD and bone markers—relevant to aging-related bone loss.

PubMed ID: 8845601

Randomized trial in postmenopausal women: higher dietary calcium reduced bone resorption and helped preserve BMD—relevant to skeletal health with aging.

PubMed ID: 8970899

RCT in elderly women showing calcium reduced spine fractures and halted forearm bone loss—relevant to preserving health with age.

PubMed ID: 7781871

RCT showed reduced vertebral bone loss with bone-directed therapy (relevant to aging bone preservation).

PubMed ID: 7703621

Postmenopausal osteoporotic trial: calcium carbonate less effective than ossein‑HA at limiting trabecular loss — relevant to bone maintenance during aging.

PubMed ID: 7565455

Elderly women RCT: HOSS calcium maintained/increased spine BMD over 18 months—supports healthier musculoskeletal aging.

PubMed ID: 7572702

Higher dietary Ca associated with less hip bone loss in postmenopausal women—supports preservation of skeletal health with aging.

PubMed ID: 7484282

2‑yr trial: 1 g/day calcium slowed hip/tibia bone loss (clinically relevant for aging skeleton).

PubMed ID: 7606425

Ca+D in vitamin D–deficient elderly raised 25(OH)D and lowered PTH—supports bone health in older adults.

PubMed ID: 7709944

4‑yr calcium RCT in postmenopausal women slowed bone loss and reduced fractures—relevant to healthy aging.

PubMed ID: 8062152

Calcium (300 mg/day) was given with 1α‑hydroxyvitamin D3 and produced modest lumbar BMD gains and fewer vertebral fractures, which can contribute to healthier aging bone outcomes; calcium was co‑administered so attribution is partial.

PubMed ID: 7942164

Long-term daily Ca (1–2 g) in perimenopausal women preserved lumbar BMD vs control—supports aging bone health.

PubMed ID: 7812072

Randomized Ca supplement trial in elderly prevented femoral BMD loss and reduced vertebral fractures—direct evidence relevant to healthy skeletal aging.

PubMed ID: 8027856

Calcium (with trace minerals) increased lumbar spine BMD over 2 years in postmenopausal women—supports skeletal health important for healthy aging.

PubMed ID: 8421475

Postmenopausal women: 1000 mg/day calcium slowed whole‑body and regional BMD loss over 2 years, a key factor in healthy musculoskeletal aging.

PubMed ID: 1612362

2000 mg/day Ca suppressed rectal epithelial proliferation in high‑risk subjects — a biologic effect relevant to long‑term health/aging.

PubMed ID: 1407240

Randomized trial: 1500 mg/day Ca modestly lowered mean BP and increased serum Ca — cardiovascular benefit relevant to healthy aging.

PubMed ID: 1611221

800 mg/day calcium in elderly women raised hip BMD and lowered PTH, supporting skeletal health in aging.

PubMed ID: 1910254

Dietary survey documents common sub‑RDA calcium intake in adults, supporting supplementation for long‑term health in aging populations.

PubMed ID: 2021138

In postmenopausal women, increased dietary calcium raised femoral-neck BMD—beneficial for aging-related skeletal health.

PubMed ID: 1991950

1.2 g/day calcium in elderly produced sustained PTH suppression, a biochemical change linked to long-term bone protection in aging.

PubMed ID: 1922205

Calcium added to exercise markedly slowed forearm bone loss in postmenopausal women, relevant to preserving function with age.

PubMed ID: 1874931

Long-term Ca supplementation reduced lumbar bone loss and bone turnover in perimenopausal women—supports an aspect of healthy aging via preserved bone mass.

PubMed ID: 2195929

Calcium (1 g/day) with calcitonin preserved BMD over 1 year—relevant to healthy aging skeletal health.

PubMed ID: 2276321

Randomized trial: 600 mg/day elemental calcium reduced precancerous esophageal changes—supports aging‑related disease prevention.

PubMed ID: 2268740

Elderly osteoporotic women given oyster‑shell calcium showed increased radial BMD over 1–2 years (supports skeletal component of healthy aging).

PubMed ID: 2387950

Direct RCT in elderly: calcium + vitamin D increased 25‑OH vitamin D and showed safety over winter—relevant to healthy aging.

PubMed ID: 16076991

Higher dairy/calcium intake improved body composition and BP in adults—metabolic benefits relevant to healthy aging.

PubMed ID: 14728632

Alfacalcidol reduced falls in elderly with >~512 mg/day calcium intake, implying interaction between calcium status and age-related fall risk.

PubMed ID: 15746990

Higher calcium intake (~1.7 g/d) reduced weight-loss–associated bone loss in older/postmenopausal women—relevant to healthy aging bone preservation.

PubMed ID: 14716192

Educational intervention substantially increased initiation of calcium (and vitamin D) supplements in target population—behavioral driver of healthy aging.

PubMed ID: 15572425

Improved calcium retention in postmenopausal women suggests benefit to bone health during aging (indirect link to healthy aging).

PubMed ID: 14695863

Vitamin D±calcium in elderly post‑hip‑fracture patients raised BMD and halved fall risk—supports aging-related outcomes with calcium as co-therapy.

PubMed ID: 15501704

Long (30 mo) Ca+D trial prevented expected bone loss in peri/postmenopausal women, relevant to healthy aging.

PubMed ID: 15231008

Winter Ca+D prevented seasonal bone loss and stabilized calciotropic hormones—relevant to preserving age-related bone changes.

PubMed ID: 14513268

Alfacalcidol + Ca prevented bone loss and reduced fractures in glucocorticoid-induced osteoporosis—supports preservation of skeletal health relevant to aging.

PubMed ID: 14610642

Raloxifene/HRT trials (with calcium given to all) increased BMD and lowered turnover—indirect evidence that calcium-containing regimens help bone health in older women.

PubMed ID: 14602746

Calcium (500 mg) + vitamin D improved BMD and lowered PTH in older vitamin D–insufficient women, supporting bone health in aging.

PubMed ID: 15040824

Large pragmatic Ca 1000 mg + D trial reduced osteoporotic fractures in elderly, a clinically meaningful outcome for healthy aging.

PubMed ID: 12568412

Vitamin D+calcium reduced falls and improved musculoskeletal function—relevant to healthy aging and fall prevention.

PubMed ID: 11916767

Older adults trial: calcium+vitamin D supplementation was associated with better preservation of whole-body and hip BMD when combined with higher protein intake, supporting bone health in aging.

PubMed ID: 12414850

Calcitriol+ERT produced durable spine BMD gains that support bone health in older adults, relevant to healthy aging.

PubMed ID: 11991447

Large Ca+vitD RCT in elderly improved BMD and vitamin D/PTH status, which supports aspects of healthy aging.

PubMed ID: 11250664

Elderly trial: low‑lactose milk powder increased calcium+vitamin D intake in frail older adults (direct relevance to nutritional support in aging).

PubMed ID: 11268708

Study on calcium+vitamin D tablet acceptability in elderly—improves likely adherence and thus long‑term bone health in older adults.

PubMed ID: 11547841

Randomized trial in postmenopausal women: 800 mg Ca/day (milk powder) attenuated bone loss — relevant to skeletal health in aging.

PubMed ID: 10620210

Calcium carbonate lowered PTH and modestly affected calcium in older patients with secondary hyperparathyroidism, supporting bone-regulating physiology relevant to healthy aging.

PubMed ID: 10846514

Micronutrient‑enriched foods (including calcium) increased bone measures in frail elderly — relevant to aging.

PubMed ID: 40154078

In older outpatients, supplement including calcium increased muscle mass—helps functional aging.

PubMed ID: 40089924

Caltrate D (calcium + D) plus exercise improved BMD vs Caltrate D alone in postmenopausal women (older population relevance).

PubMed ID: 39861392

Daily calcium maltobionate preserved bone density in adults—relevant to musculoskeletal health in aging.

PubMed ID: 38467003

Large randomized trial of daily calcium (400 mg) + vitamin D with long‑term mortality outcomes (reduced cancer mortality) — directly relevant to long‑term healthy‑aging endpoints.

PubMed ID: 37120127

Dietary intervention in dialysis changed PTH/FGF23/serum calcium — relevant to long‑term mineral homeostasis that affects aging-related bone/metabolic health.

PubMed ID: 37861611

RCT in older edentulous women: multi‑nutrient supplement containing calcium produced within‑group BMD improvements relevant to aging bone health.

PubMed ID: 37389558

Large RCT in aged-care increased dietary Ca/protein and reduced fractures — directly relevant to healthy aging.

PubMed ID: 36336861

High‑dose vitamin D in elderly altered vitamin D metabolites and preserved normocalcemia — relevant to calcium homeostasis in older adults linked to healthy aging.

PubMed ID: 36141627

Oral supplement including 400 mg Ca/day increased calcium intake and weight in at‑risk adults—useful for nutritional status in older/at‑risk adults.

PubMed ID: 36364934

Calcium-HMB + vitamin D preserved thigh muscle and reduced intramuscular fat in middle-aged sedentary women—supports age-related muscle preservation.

PubMed ID: 35466448

Romosozumab increases BMD and reduces vertebral fractures—preserves skeletal health important for aging.

PubMed ID: 36271471

Phase‑3 TransCon PTH normalized calcium handling and reduced conventional therapy burden—beneficial for aging patients with hypoparathyroidism.

PubMed ID: 33745624

Higher dietary calcium (≥RDA) linked to lower CAD odds in this population—moderate relevance to aging/vascular health.

PubMed ID: 38032288

Exercise + nutrition program including Caltrate (600 mg Ca) improved muscle mass/strength and reduced inflammation in older adults — relevant to healthy aging.

PubMed ID: 31338563

13-week Ca + vitamin D + leucine trial in sarcopenic older adults showed improved BMD and lowered PTH — supports aspects of healthy aging (bone/muscle preservation).

PubMed ID: 15658548

Postmenopausal osteopenic women given a multinutrient product containing 600 mg Ca showed modest spine/hip BMD increases, supporting age-related bone health.

PubMed ID: 22170363

Large RCT: Ca + vitamin D–fortified juice reduced visceral adipose tissue, a metabolic marker relevant to healthy aging.

PubMed ID: 15705599

Higher dietary calcium associated with markedly lower lymphocyte micronucleus frequency (marker of genome instability) — observational but biologically relevant to aging.

PubMed ID: 17896582

AKG‑Ca reduced bone resorption marker in older postmenopausal women, relevant to skeletal health during aging.

PubMed ID: 8028755

Combination therapy improved BMD and lowered PTH/markers in elderly osteoporotic patients — directly relevant to preserving bone health with age.

PubMed ID: 34670754

Large RCT in aged-care increased dietary calcium/protein and reduced fractures/falls—directly supports healthy aging outcomes.

PubMed ID: 32622071

Vitamin D3 + calcium given to older adults altered bone markers (DLK1/VCAM) and BMD—supports aspects of skeletal health in aging.

PubMed ID: 32722015

Fortified dairy (including calcium+vitamin D/K) improved bone mass and turnover in menopausal women — relevant to preserving musculoskeletal health in aging.

PubMed ID: 32280092

Personalized Ca:Mg ratio RCT showed cognitive/epigenetic benefits in older adults, consistent with healthier aging mechanisms.

PubMed ID: 31101439

Large cross-sectional data document widespread inadequate dietary calcium in adults with metabolic syndrome — indicates relevance of calcium intake to healthy aging.

PubMed ID: 31489467

Dried beancurd (contains calcium) increased lumbar spine BMD in postmenopausal women—may contribute to healthier musculoskeletal aging.

PubMed ID: 31126121

In postmenopausal women Ca+D or extra dairy preserved BMD and lean mass during weight loss—supports aspects of healthy aging.

PubMed ID: 31543516

Large prospective data: moderate–high dietary calcium (1200–1600 mg/d) associated with lower advanced colorectal neoplasia — relevant to long-term healthy aging outcomes.

PubMed ID: 31779179

Fortified yogurt (Ca+D) improved gait variability and cognition in older women—direct functional effects relevant to healthy aging.

PubMed ID: 30117164

Large randomized-trial meta/analysis: 1200 mg/day calcium reduced colorectal adenomas in some subgroups — possible aging/cancer‑prevention benefit though heterogeneous.

PubMed ID: 28148500

Large RCT of calcium+vitamin D showed fracture protection in a genetic subgroup — relevant to healthier aging via preserved skeletal health.

PubMed ID: 28654155

Large WHI RCT (Ca+D) showed a modest relative reduction in hematologic cancer incidence over 10 years—plausibly relevant to healthy aging.

PubMed ID: 27301220

Nutritional intervention increased calcium intake and improved BMD in osteoporosis patients, which relates to healthier aging skeleton.

PubMed ID: 27552840

Large RCT increased dietary calcium intake and bone‑loading activity—directly improves long‑term bone health risk factors important for healthy aging.

PubMed ID: 26222774

Derived from the CAIFOS cohort (originally randomized to calcium) — long-term mortality associations link mineral metabolism/OPG and aging outcomes.

PubMed ID: 26107684

Postmenopausal trial: Ca+D3 produced modest lumbar BMD gains and functional benefits when combined with exercise (relevant to healthy ageing bone/function).

PubMed ID: 25626413

High-calcium milk powder slowed lumbar spine bone loss and reduced height loss in postmenopausal women, which supports healthier musculoskeletal aging.

PubMed ID: 25112087

Trial of daily calcium in osteoporosis showed BMD and symptom improvements; supports aspects of healthy aging (bone health) though confounded by added moxibustion.

PubMed ID: 25323601

Lower vertebral bone density and fractures predicted higher mortality—links bone health to aging outcomes.

PubMed ID: 24115138

Post‑parathyroidectomy calcium regimens produced BMD gains relevant to preserving bone mass with aging.

PubMed ID: 23799356

WHI Ca+D trial showed hip-fracture prevention when combined with HT, relevant to aging-related fracture risk and skeletal health.

PubMed ID: 24155106

Large RCT in older women showing 1.2 g/day Ca carbonate did not worsen carotid IMT and higher total Ca linked modestly to less atherosclerosis — relevant to safety/aging.

PubMed ID: 23652464

Community program increased Ca/vitamin D uptake and halved hip fractures over 10 years—supports healthy aging outcomes in elderly women.

PubMed ID: 23684755

Large trial showed higher mortality with calcium binder vs non‑calcium — major aging/health outcome.

PubMed ID: 23911336

Large observational study: higher dairy (calcium-containing foods) associated with greater muscle mass/function and mobility in older women, relevant to healthy aging.

PubMed ID: 24064695

Large RCT of 1200 mg/day calcium reduced bone turnover—supports skeletal health preservation relevant to healthy aging.

PubMed ID: 23681085

500 mg/day calcium in elderly women lowered bone turnover and preserved spine BMD—relevant to age‑related bone loss.

PubMed ID: 22799523

Analysis from an older-women cohort (derived from a calcium-trial population) showing eGFR predicts atherosclerotic events — indirectly relevant to aging and long-term skeletal/vascular health.

PubMed ID: 21527171

Multi-component nutrition including calcium+vitamin D in malnourished elderly improved weight/function — supports aspects of healthy aging (calcium included as part of intervention).

PubMed ID: 22111816

Observational hemodialysis cohort: use of calcium carbonate associated with lower all-cause mortality versus sevelamer (associative, not randomized).

PubMed ID: 22214657

Osteoporosis guideline dissemination increased advice on dietary calcium/vitamin D—programmatic support for aging bone health.

PubMed ID: 21342323

Hemodialysis trial showing less aortic calcification when avoiding calcium-based binders — important for vascular aging and harms of excess calcium exposure.

PubMed ID: 21880848

Large RCT (calcium 1 g + vit D 400 IU) showed modest reductions in total and breast cancer in women not already taking supplements — plausible contributor to healthy aging.

PubMed ID: 20370938

Postmenopausal RCT with ~1200 mg Ca+vit D increased spine and total-body BMD, a mechanism relevant to healthy aging.

PubMed ID: 22254070

Large feedback intervention increased calcium intake in older women—relevant to healthy aging via improved intake.

PubMed ID: 20193095

Year-long Ca+vitD RCT improved femoral bone measures and lowered PTH—supports aspects of healthy aging (bone health) but effect includes vitamin D.

PubMed ID: 20204604

Daily vitamin D+1000 mg calcium modestly increased total-body BMD over 3 years in older women—supports musculoskeletal aging

PubMed ID: 21054285

Vitamin D + calcium improved muscle strength/mobility in the weakest older-women subgroup—functional aging benefit

PubMed ID: 19262561

Elderly women RCT: calcium-containing product (Caltrate D) was associated with greater lumbar spine BMD gains when combined with calcitriol, supporting bone health in older adults.

PubMed ID: 19244376

Elderly nursing-home trial: vitamin D + 320 mg Ca increased BMD and lowered PTH — direct relevance to bone health in aging.

PubMed ID: 10999778

Trial in older adults showed prevention of hip BMD loss with calcium — relevant to healthy aging.

PubMed ID: 19317814

Oral calcium (1500 mg/d) improved insulin sensitivity in diabetics—metabolic benefit relevant to healthy aging.

PubMed ID: 19118956

Postmenopausal women given calcium/vitamin D‑fortified dairy + lifestyle had modest improvements in muscle and leg composition relevant to healthy aging.

PubMed ID: 18629569

Ca + vitamin D reduced falls and improved muscle/balance in elderly — improves functional aging (note: combined intervention).

PubMed ID: 18541589

Reduced minimal‑trauma fractures during 4‑yr calcium treatment — meaningful for older adults' healthy aging.

PubMed ID: 18092326

Reanalysis of WHI Ca+D data suggests calcium+vitamin D may alter colorectal cancer risk depending on estrogen use—implicates calcium in long-term health outcomes.

PubMed ID: 17457450

Observational study links low calcium intake/low activity with high osteopenia/osteoporosis prevalence in men—supports role of calcium in healthy skeletal aging (indirect).

PubMed ID: 17667193

Self-management program increased awareness/behavior around calcium intake and improved function/QoL in older osteoporotic women — relevant to healthy aging.

PubMed ID: 17823446

Postmenopausal women: fortified dairy+vitD improved BMD/markers vs calcium pills — relevant to aging bone health though not calcium-only.

PubMed ID: 17616788

In older fracture patients Ca+D reduced bone turnover and preserved/increased spine BMD, which supports skeletal health in aging.

PubMed ID: 17291843

Exercise preserved spine BMD in early postmenopausal women—relevant to healthy aging bone maintenance (indirect to calcium supplementation).

PubMed ID: 16699126

Education intervention increased calcium supplement use in low-income older adults (direct behavioral support for aging population).

PubMed ID: 16822627

Randomized nutrition program that increased dairy (calcium) intake and improved BMI/LDL over 5 months, implying cardiometabolic and weight benefits relevant to healthy aging.

PubMed ID: 16508700

Vitamin D + calcium markedly reduced falls and improved balance in institutionalized elderly.

PubMed ID: 16725396

Two-year Ca+D–fortified milk preserved cortical bone geometry and strength in older men, supporting skeletal aspects of healthy aging.

PubMed ID: 16505262

Randomized Ca+D (500 mg Ca + 700 IU D) reduced falls in older women — clinically relevant for healthy aging/fall prevention.

PubMed ID: 16636212

1200 mg/day Ca trial: ITT fracture reduction neutral but compliant subgroup had fewer fractures and BMD gains, suggesting benefit with adherence in older adults.

PubMed ID: 15812582

Screening/advice that included recommending calcium+vitamin D was associated with large fracture reduction in older women, supporting aspects of healthy aging.

PubMed ID: 16491287

RCT in older men: Ca+D reduced age-related bone loss and lowered PTH—relevant to healthier musculoskeletal aging.

PubMed ID: 31338563

BMD increase and suppressed PTH with Ca+vitD+leucine in older, sarcopenic adults supports bone-related recovery/rehabilitation contexts.

PubMed ID: 2195929

Demonstrated BMD preservation with therapy—supports recovery/rehabilitation of bone mass.

PubMed ID: 2021138

Increased femoral-neck BMD with dietary calcium may facilitate recovery from skeletal injury (indirect).

PubMed ID: 2023034

Collagraft (calcium phosphate + collagen) matched autograft effectiveness for fracture grafting — strong evidence for bone-related recovery applications of calcium-containing materials.

PubMed ID: 1810080

Pamidronate rapidly reduced bone resorption and urinary Ca in osteoporosis — relevant to bone recovery processes (strong drug evidence).

PubMed ID: 1825515

CL2MDP decreased urinary Ca and hydroxyproline with reduced analgesic need in bone metastases — supports bone symptom/recovery management.

PubMed ID: 1422320

BMD and bone marker improvements in postmenopausal osteoporosis suggest benefit for bone recovery/rebuilding (co‑treated with ipriflavone).

PubMed ID: 8292845

Calcitonin after hip fracture lowered bone‑resorption markers and urinary mineral changes—relevant to recovery after skeletal injury.

PubMed ID: 7639438

Significant increases in spinal/femoral bone mass and fewer vertebral fractures with fluoride added to continuous Ca—shows contribution of Ca-inclusive therapy to skeletal recovery.

PubMed ID: 8569136

Supplemented preterm formula produced improved calcium retention—supports bone recovery and mineral repletion in infants.

PubMed ID: 8775626

Parathyroidectomy produced early BMC gains in mild hyperparathyroidism compared with conservative management — relevant to recovery of bone mass after intervention affecting calcium metabolism.

PubMed ID: 7752008

Preterm nutrient enrichment restoring mineral status supports neonatal bone recovery/normalization.

PubMed ID: 7781871

Demonstrated preservation of vertebral BMD over 18 months—relevant to recovery of bone health after loss.

PubMed ID: 7580056

Reported lumbar BMD changes vs calcium control—relates to short‑term bone recovery assessments.

PubMed ID: 8599316

Post-weaning increases in calcium absorption and calcitriol help restore calcium balance and bone after lactation—directly relevant to bone recovery.

PubMed ID: 8845601

Higher calcium intake reduced resorption and preserved BMD—supports recovery/maintenance of bone stores.

PubMed ID: 8997677

Local calcium implant improved periodontal healing outcomes—relevant to bone-related recovery after periodontal surgery.

PubMed ID: 8805994

Increases in bone-formation markers with calcitriol and higher calcium indicate potential to support bone recovery processes.

PubMed ID: 8633378

Calcium + alphacalcidol showed clinically meaningful preservation of BMD and fewer fractures—relevant to recovery after bone stress.

PubMed ID: 8704358

Marked lumbar BMD gains with Ca+MFP vs Ca alone indicate strong bone recovery/preservation potential in steroid‑treated patients.

PubMed ID: 9014744

Clodronate + chemo normalized bone resorption markers in myeloma patients — shows capacity to reverse excessive bone breakdown, relevant to recovery.

PubMed ID: 9111393

Calcium‑containing composite graft supported fracture union comparable to autograft—relevant to post‑injury bone recovery (local, not systemic calcium).

PubMed ID: 9164808

Higher mineral intake in infancy increased BMC during rapid growth — relevant to bone recovery/accumulation phases in early life.

PubMed ID: 9099188

Active vitamin D plus background calcium preserved BMD and reduced hip fractures in hemiplegic stroke patients — evidence relevant to recovery of bone health during immobilization.

PubMed ID: 9388377

Active vitamin D + calcium improved BMD and reduced fractures in osteoporotic elders — supports bone recovery/rehabilitation.

PubMed ID: 9385282

Calcitonin + calcium produced marked BMD increases over 12 months — applicable to recovery from bone loss/osteoporosis.

PubMed ID: 9164833

Calcium supplementation slowed bone loss after Colles' fracture and calcitonin addition increased cortical mass—direct evidence for bone recovery support.

PubMed ID: 9205633

Etidronate trial where calcium 500 mg/day was standard therapy — informative about calcium's role during therapeutic bone recovery contexts.

PubMed ID: 9166391

Ipriflavone trial used calcium 1 g/day background — provides direct context for bone remodeling during recovery/therapy.

PubMed ID: 9880180

HA/TCP coating (calcium phosphate) improved implant fixation and interface radiography at 2 years — relevant to bone-related recovery after arthroplasty/implantation.

PubMed ID: 10451461

Rickets trial: calcium (±vitamin D) produced radiographic healing and biochemical recovery—direct evidence for bone-related recovery.

PubMed ID: 9925837

Feeding strategies improving calcium retention in preterm infants support skeletal recovery/mineral accrual.

PubMed ID: 10367032

Alfacalcidol prevented steroid-related spine bone loss (clinically meaningful BMD preservation)—relevant to bone recovery/maintenance.

PubMed ID: 10480411

Post–heart-transplant cohort receiving Ca showed progressive increases in spine BMD over 3 years — supports bone recovery in high-risk patients.

PubMed ID: 10372699

Calcium prevented BMD loss and supported accrual during medical therapy that otherwise reduces bone mass — relevant to bone recovery during/after treatment.

PubMed ID: 10501793

Calcium supplementation after transplant reduced certain femoral bone losses—strong evidence for aiding bone recovery/maintenance in that context.

PubMed ID: 9951784

Calcium+calcitriol prevented BMD loss and blunted PTH rise after pamidronate, aiding skeletal recovery post‑treatment.

PubMed ID: 10191737

Calcium‑phosphate bone cement allowed faster early functional recovery in distal radius fractures—direct bone recovery evidence.

PubMed ID: 11108415

Supplement (including 800 mg calcium) reduced post‑hip‑fracture complications — moderate support for recovery-related outcomes.

PubMed ID: 10929446

Alfacalcidol with higher calcium improved spine BMD and reduced back pain in steroid users—supports recovery of bone health.

PubMed ID: 10648270

Year-long calcium supplementation increased BMC/BMD in children, implying enhanced capacity for bone recovery in a low-calcium population.

PubMed ID: 10990311

Calcium‑based bone cement improved functional recovery and reduced malunions following distal radius fractures — clear support for bone‑related recovery.

PubMed ID: 11218508

Coral‑calcium bone graft produced marked improvements in periodontal healing outcomes — strong evidence for bone‑related recovery after surgery.

PubMed ID: 10749632

Porous calcium phosphate ceramic graft integrated within 12 months and avoided donor-site morbidity — strong evidence for bone-related recovery after surgery.

PubMed ID: 11277275

Cyclical etidronate + calcium and calcitriol reduced transplant‑related early bone loss and showed carryover—stronger evidence for aiding bone recovery.

PubMed ID: 11504259

Calcium sulfate pellets as graft substitute produced substantial bone formation in spinal fusion — directly supports bone-related recovery after surgery.

PubMed ID: 11503113

Calcium‑containing coating preserved periprosthetic bone—relevant to recovery around joint replacement and bone-related rehabilitation.

PubMed ID: 12490862

Perioperative oral calcium (±vit D) markedly reduced symptomatic hypocalcemia and IV calcium use after thyroidectomy—direct recovery benefit.

PubMed ID: 12409657

Surgical exploration strategy altered early postoperative hypocalcemia incidence and calcium medication use—affecting recovery course.

PubMed ID: 11889427

Calcitriol with calcium produced large lumbar spine BMD gains over 2 years after heart transplant, indicating support for post‑transplant bone recovery.

PubMed ID: 12039990

Calcium plus active vitamin D reduced early post‑transplant bone loss, supporting bone recovery after transplantation.

PubMed ID: 12521277

Demonstrated radiographic and biochemical recovery from rickets with calcium ± vitamin D.

PubMed ID: 14630841

Calcium‑phosphate cement accelerated early functional recovery after distal radius fractures and reduced infection — strong support for bone‑related recovery in surgical repair.

PubMed ID: 12929879

Rapid rickets healing with calcium demonstrates strong support for bone-related recovery in deficient children.

PubMed ID: 14569109

Alfacalcidol + calcium prevented early post‑transplant bone loss—supports bone recovery/maintenance after major physiologic stress.

PubMed ID: 14513268

Large BMD gains and fracture reductions with alfacalcidol + calcium indicate benefit for bone recovery in osteoporotic contexts.

PubMed ID: 14600695

Calcium hydroxide enhanced hard‑tissue bridging in pulp capping — direct evidence of calcium material supporting tissue recovery in dental bone‑like tissue.

PubMed ID: 14582545

Calcium–phosphate cement augmentation improved early mechanical stability after femoral neck fracture—supports recovery outcomes.

PubMed ID: 15386160

Ca+D increased fracture-site BMD and callus formation at 6 weeks—direct support for recovery after bone injury.

PubMed ID: 15448423

Fortified milk in VLBW infants improved mineral intake and markers related to bone mineralization and early growth — supports recovery in fragile infants.

PubMed ID: 15502727

Calcium + calcitriol reversed/attenuated bone loss in transplant patients—relevant to recovery of bone mass in clinical settings.

PubMed ID: 14717945

Intermittent calcitriol + calcium preserved hip BMD after renal transplant—supports bone recovery/maintenance.

PubMed ID: 15024332

Hip-fracture immobilized patients: etidronate improved calcium balance and reduced resorption—directly relevant to post-fracture mineral recovery.

PubMed ID: 15105027

Post‑hip fracture nutritional supplement increased calcium intake and improved albumin—supports recovery.

PubMed ID: 15241158

HAP/TCP coating improved radiographic integration and bony ingrowth around implants—strong evidence that calcium‑containing materials support bone recovery after implantation.

PubMed ID: 16332231

rhPDGF + beta‑TCP significantly improved periodontal defect fill—evidence for enhanced local bone recovery using a calcium-containing matrix.

PubMed ID: 16105530

Prophylactic calcium ± higher-dose calcitriol markedly reduced symptomatic and severe postoperative hypocalcemia—important for recovery after thyroidectomy.

PubMed ID: 15936361

Calcium phosphate graft substitute produced reliable cervical fusion and quicker recovery metrics — strong evidence for bone-related recovery aid.

PubMed ID: 16094268

Calcium‑phosphate carrier with rhBMP‑2 accelerated and improved spinal fusion — strong surgical bone-recovery evidence.

PubMed ID: 16129742

Calcium‑phosphate cement augmentation improved early recovery after unstable hip fractures.

PubMed ID: 16093464

Maintaining/increasing BMD after PTH then alendronate supports longer‑term structural recovery/maintenance.

PubMed ID: 16352692

Continuing antiresorptives or switching preserved BMD in patients on Ca/vitD—recovery/maintenance relevance.

PubMed ID: 16365721

Calcium hydroxide paste improved periodontal wound healing metrics versus surgery alone—relevant to local bone/attachment recovery.

PubMed ID: 16647414

Behavioral calcium increase in JRA patients produced greater BMC gains, supporting recovery of bone deficits in a disease context.

PubMed ID: 17071205

Perioperative oral Ca+D after thyroidectomy significantly reduced symptomatic and laboratory hypocalcemia — supports recovery of calcium homeostasis after surgery.

PubMed ID: 16837920

Lowering dialysate Ca markedly restored bone formation and biopsy-proven normalization—strong evidence for bone recovery in adynamic bone disease.

PubMed ID: 16752286

Surgical augmentation with calcium-phosphate cement directly targeted early fixation and recovery in femoral neck fractures (no long-term benefit).

PubMed ID: 17092241

EMD with tricalcium phosphate improved periodontal bone outcomes — supports bone recovery in oral surgery context.

PubMed ID: 17616788

In fracture patients Ca+D preserved/increased spine BMD and lowered bone-turnover markers over 12 months, aiding recovery.

PubMed ID: 17498850

Post‑hip‑fracture population receiving calcium+vitamin D as baseline showed whole‑body BMD increases with additional nutritional therapy — directly relevant to recovery contexts.

PubMed ID: 17437343

Oral calcium+vitamin D started immediately after total thyroidectomy reduced symptomatic hypocalcaemia and shortened hospital stay—supports recovery of calcium-related bone/metabolic homeostasis after surgery.

PubMed ID: 18834243

Local calcium sulfate graft improved periodontal healing — supports local bone/periodontal recovery.

PubMed ID: 18541589

Reduced minimal‑trauma fractures during treatment indicates on‑treatment bone resilience and relevance to recovery contexts.

PubMed ID: 19035501

Pediatric Ca supplementation increased BMD, supporting recovery/maintenance of skeletal health in growing children with JRA.

PubMed ID: 18492840

Higher-calcium/dairy intake reduced bone loss during weight-loss and maintenance phases, supporting skeletal recovery from catabolic stress.

PubMed ID: 18433305

Calcium + vitamin D lowered stress-fracture incidence in recruits, supporting bone resilience and recovery under high mechanical load.

PubMed ID: 18829901

Calcium phosphate cement reduced subsidence after tibial plateau fracture repair—direct application to bone recovery.

PubMed ID: 18246390

IOPTH-guided selective autotransplantation reduced transient hypocalcemia and postoperative oral Ca needs—directly relevant to managing Ca in recovery after parathyroid surgery.

PubMed ID: 19082847

Beta‑TCP graft showed durable spinal fusion outcomes — relevant to bone recovery after surgery.

PubMed ID: 18496340

Beta-TCP provided equivalent fusion outcomes to autograft in humans—strong evidence for aiding postoperative bone recovery.

PubMed ID: 18301927

Interbody beta-TCP cages achieved high fusion rates and support postoperative bone recovery (human data).

PubMed ID: 18705811

Calcium-containing graft material directly promoted new bone in sinus grafts — relevant to local bone-related recovery and reconstruction.

PubMed ID: 19905932

Calcium-containing graft improved periodontal outcomes—evidence of bone-related recovery support at surgical sites.

PubMed ID: 19335074

β‑TCP graft with growth factor produced periodontal regeneration—supports recovery of bone structures.

PubMed ID: 19820600

Local calcium-phosphate implant reduced radiographic collapse after fracture — supports bone-related structural recovery.

PubMed ID: 19139662

Calcium‑phosphate cement used for vertebral fractures implicates calcium in post‑procedural bone structural recovery (biomaterial context).

PubMed ID: 20139574

CPC produced large clinical improvements (probing depth and attachment gain) in periodontal bone defect healing—strong bone‑related recovery evidence.

PubMed ID: 19865631

Extraction socket grafting with calcium sulfate improved ridge preservation and trabecular bone—relevant to recovery after dental bone loss/surgery.

PubMed ID: 20484446

Calcium salts supported BMD gains in osteoporotic patients on teriparatide—assists recovery of bone mass

PubMed ID: 21133980

rhPDGF-BB + β‑TCP significantly improved bone fill and soft-tissue healing in periodontal defects—supports bone-related recovery

PubMed ID: 20544178

Improved bone structural measures in growing girls support recovery/strengthening of bone.

PubMed ID: 21153900

Long-term dietary Ca+vitD lowered bone turnover markers and improved BMD—favors bone recovery/maintenance.

PubMed ID: 20546250

Calcium‑containing β‑TCP grafts supported new bone formation in sinus augmentation — relevant to surgical bone recovery.

PubMed ID: 20657257

Calcium‑sulfate bone substitute facilitated infection eradication with fewer reoperations and supported union rates—direct clinical application of calcium-containing material in bone recovery.

PubMed ID: 20708511

Faster apical barrier formation with calcium hydroxide shows accelerated mineralized‑tissue recovery in endodontic treatment—direct evidence of bone/related tissue recovery acceleration (dental).

PubMed ID: 21837695

Routine calcium + vitamin D after thyroidectomy lowered hypocalcemia rates and accelerated correction when used—directly supports post-surgical calcium-related recovery.

PubMed ID: 21843948

α‑tricalcium phosphate graft produced new bone after jaw surgery — supports recovery at bone defect sites.

PubMed ID: 21797917

β‑TCP grafts led to new bone in sinus augmentation — evidence for bone-related recovery with Ca-containing materials.

PubMed ID: 22232815

Calcium sulphate cement use in calcaneal fractures associated with better early function/recovery vs open surgery.

PubMed ID: 21909466

Injectable calcium sulfate aided filling of bone defects with predictable resorption and comparable healing—direct bone‑recovery evidence.

PubMed ID: 21364273

Alfacalcidol + alendronate + Ca improved BMD/strength over 36 months—strongly relevant to bone recovery/rehabilitation.

PubMed ID: 22166162

Clear clinical evidence that a calcium sulfate graft increased new bone formation and cleared faster — strongly supports post‑extraction bone recovery.

PubMed ID: 22168624

BCP grafts promoted new bone formation after sinus lift, supporting recovery in maxillary alveolar bone for implant rehabilitation.

PubMed ID: 22957911

Short dental implants with nanometer CaP surface had slightly less peri‑implant bone loss — indicates CaP surfaces support local bone preservation/recovery.

PubMed ID: 23104564

Children with rickets had radiological/biochemical recovery with calcium + vitamin D—strong evidence for bone recovery support.

PubMed ID: 22309243

Calcium‑enriched endodontic cement promoted root/ hard‑tissue recovery in immature teeth.

PubMed ID: 22538473

Sinus augmentation study showing new bone formation with calcium‑containing substitutes — direct support for bone recovery after grafting.

PubMed ID: 22866291

Calcium‑incorporated implant surface facilitating osseointegration supports bone-related recovery after implant placement.

PubMed ID: 22612371

Ca‑phosphate bone substitute + enamel matrix derivative produced substantial periodontal bone regeneration — supports bone recovery using calcium‑based materials.

PubMed ID: 23168135

Calcium‑phosphate graft improved radiographic donor‑site bone repair—applicable to bone recovery after surgical harvest.

PubMed ID: 23189308

Calcium‑containing graft materials used in sinus augmentation increased bone density after 5 months, relevant to postoperative bone recovery.

PubMed ID: 22736463

Supersaturated calcium‑phosphate rinse shortened mucositis duration and reduced analgesic/TPN needs after HSCT—supports oral recovery in a bone‑marrow transplant context.

PubMed ID: 22892064

Significant new bone formation and high implant success rates indicate strong support for bone‑related recovery after grafting.

PubMed ID: 22612364

β‑TCP+PDGF markedly increased bone fill and percent bone fill in periodontal defects — supports recovery of bone function/structure at defect sites.

PubMed ID: 22324456

Sinus augmentation with calcium‑based substitutes produced new bone and differing residual material — supports surgical bone recovery.

PubMed ID: 22161686

PTH(1-84) produced structural bone improvements in patients on calcium therapy — relevant to therapeutic bone recovery contexts.

PubMed ID: 22685164

Post-hip-fracture ONS (all patients on calcium/vit D) accelerated rehab and reduced complications — directly relevant to recovery after skeletal injury.

PubMed ID: 23719547

Calcium+D in adolescent mothers reduced lactation-related bone loss and increased spine BMC—recovery of maternal bone mass during/after pregnancy.

PubMed ID: 24010637

Ca+D improved BMD in men on antiepileptics; co-intervention with bisphosphonate prevented fractures—relevant to recovery/secondary prevention.

PubMed ID: 24157403

Combination Ca intake + exercise increased BMD — helpful for bone recovery/rehabilitation contexts.

PubMed ID: 23824386

β-tricalcium phosphate with rhPDGF-BB provided non-inferior fusion and clinical healing versus autograft — strong evidence for calcium-phosphate material in bone recovery.

PubMed ID: 23324964

β‑TCP graft demonstrated radiographic signs of bone fill and remodeling consistent with support for bone recovery after defects/implantation.

PubMed ID: 24253788

Direct RCT of a calcium phosphate bone graft substitute for spinal fusion — addresses bone‑related recovery in surgery.

PubMed ID: 24748637

Rickets treatment demonstrating faster healing with calcium ± vitamin D—strong evidence for recovery from calcium‑deficiency bone disease.

PubMed ID: 24600660

β-TCP scaffold aided periodontal/regenerative outcomes—direct support for localized bone-related recovery.

PubMed ID: 25454818

Calcium‑sulfate graft yields substantial new bone in extraction sockets—directly supports localized bone recovery after injury/surgery.

PubMed ID: 24325663

Sinus lift grafts (calcium‑based materials) maintained graft height and remodeled appropriately, supporting recovery.

PubMed ID: 24115138

Calcium (± vitamin D) produced measurable BMD recovery after parathyroidectomy — strong evidence for bone recovery support.

PubMed ID: 25467231

Endodontic outcomes favored MTA over Ca(OH)2 on apical closure and fractures — supports dental recovery contexts where Ca is used.

PubMed ID: 25432324

Ca-containing bone graft substitute produced comparable fusion to autograft and reduced morbidity — strong support for bone-related recovery after surgery.

PubMed ID: 25265123

Calcium-containing graft materials improved post-extraction bone quality — relevant to bone recovery after injury/surgery.

PubMed ID: 24843955

Oral calcium carbonate + vitamin D3 improved clinical symptoms in skeletal fluorosis—a bone recovery context.

PubMed ID: 25073446

Calcium-containing grafts correlated with better mechanical stability of implants — supports recovery of bone function after augmentation.

PubMed ID: 24683578

Calcium-containing graft materials influenced bone turnover and early healing at dental extraction sites — relevant to localized bone recovery.

PubMed ID: 25848134

Calcium-phosphate scaffold with growth factor accelerated fusion and clinical success — direct support for bone recovery after surgery.

PubMed ID: 26075752

By attenuating ART-associated bone loss, vitamin D3+calcium supports recovery/preservation of skeletal health during treatment-related bone insult.

PubMed ID: 25626413

Long-term high-calcium milk slowed spinal bone loss and height loss after menopause—supports bone recovery/maintenance.

PubMed ID: 26009922

Calcium‑containing bone ceramic with PDGF compared favorably to autograft for ridge augmentation—supports bone recovery.

PubMed ID: 26439386

Hydroxyapatite graft in periodontal defects gave strong bone fill—direct support of local bone recovery.

PubMed ID: 26174080

Local Ca‑phosphate graft improved periodontal bone/attachment recovery—relevant to localized bone recovery.

PubMed ID: 26708858

Thyroidectomy surgical technique influenced immediate calcemia and discharge need for Ca/vit D supplements—relevant to postoperative Ca recovery decisions.

PubMed ID: 25954758

Calcium phosphate substitutes increased implant insertion torque indicating improved bone support during recovery.

PubMed ID: 26255474

Strongest direct evidence: postoperative calcium+calcitriol (with adjuncts) improved pain/function and BMD after kyphoplasty—supports bone recovery.

PubMed ID: 26214887

Faster fracture healing and better bone marker profile in patients receiving calcium carbonate as baseline therapy (with adjunct) support bone recovery contexts.

PubMed ID: 25636048

Correction of hyperparathyroidism restored calcium homeostasis and increased BMD—directly relevant to bone recovery via normalized calcium physiology.

PubMed ID: 27311415

Faster radiographic healing of rickets with higher Ca doses supports bone recovery in pediatric deficiency.

PubMed ID: 27422705

Surgical use of calcium sulfate cement influenced wound complications and structural surgical outcomes—directly relevant to bone recovery after fracture.

PubMed ID: 26908630

Periodontal regeneration with β‑TCP scaffold and growth factor significantly increased bone fill around teeth—supports dental bone-related recovery.

PubMed ID: 26961287

Calcium‑containing hydroxyapatite/collagen implant accelerated and improved bone regeneration—direct support for bone recovery interventions.

PubMed ID: 27734257

rhPTH(1–84) allowed major reductions in oral calcium/vitamin D while maintaining calcium control in hypoparathyroidism—facilitates recovery of calcium homeostasis.

PubMed ID: 28043751

CaP graft data show effective integration and tunnel filling after ACL reconstruction — directly relevant to bone‑related recovery after surgery.

PubMed ID: 26922214

Use of calcium-containing synthetic grafts at tooth extraction sites preserved ridge width—strong direct evidence that calcium-based grafts support bone healing and structural recovery.

PubMed ID: 27683073

Sinus augmentation with calcium‑based grafts produced bone formation and better volume maintenance—directly relevant to surgical bone recovery.

PubMed ID: 26879200

Significant long‑term BMD increases during odanacatib exposure (with supplemental calcium/Vit D) support recovery/rehabilitation of bone mass, though drug-driven.

PubMed ID: 26855045

Calcium‑phosphate cement supported bone stability in osteotomy and is directly relevant to post‑operative bone recovery.

PubMed ID: 29100829

Bone graft material comparison with measures of new bone and maturation — relevant to recovery after grafting/augmentation.

PubMed ID: 28522130

Parathyroidectomy cohort: baseline urinary calcium and PTH predicted hip BMD recovery; calcium was part of post‑op supplementation—directly relevant to bone recovery.

PubMed ID: 28697860

Multimodal perioperative nutrition (including Ca) reduced hypocalcaemia and shortened hospitalization after knee surgery—direct support for post‑op recovery of bone/electrolyte status.

PubMed ID: 28703478

Biphasic calcium phosphate materials markedly increased new bone in sockets—strong support for bone‑related recovery post‑extraction.

PubMed ID: 28528472

Post‑thyroidectomy combined iPTH/serum Ca measurement predicts early hypocalcemia and guides Ca/VitD supplementation and safe discharge — directly relevant to postoperative Ca management and recovery.

PubMed ID: 28019683

Trial in elderly hip‑fracture patients showed greater BMD gains and improved early mobility with therapies given on a calcium/vitamin D background — directly relevant to bone‑related recovery.

PubMed ID: 28915914

β-TCP-containing screws modified bone tunnel remodeling—relevant to recovery of bone architecture after surgery.

PubMed ID: 28748492

CaP-hybridized grafts reduced tunnel enlargement, indicating enhanced local bone recovery after ACL reconstruction.

PubMed ID: 29947083

Burosumab improved fracture healing rates—supports bone recovery processes in XLH patients (mechanism not supplemental Ca).

PubMed ID: 30592368

Calcium‑based graft materially reduced ridge resorption and preserved bone after extraction — strong support for local bone recovery.

PubMed ID: 30377715

Tri‑calcium phosphate granules supported bone union progression comparable to allograft in osteotomy — clinical support for bone recovery using Ca materials.

PubMed ID: 30521656

Calcium phosphate graft yielded comparable bone formation in sinus augmentation—supports bone recovery for implant placement.

PubMed ID: 30594226

CaP‑hybridized graft reduced postoperative femoral tunnel enlargement—strong evidence for improved bone‑related surgical recovery.

PubMed ID: 30465358

Intracanal calcium hydroxide produced large radiographic lesion resolution—relevant to dental bone recovery.

PubMed ID: 29652784

Calcium‑phosphate graft in lumbar fusion directly supports bone repair and recovery after surgery.

PubMed ID: 30817733

Perioperative multimodal nutrition (including calcium) improved postoperative electrolyte balance and calcium levels after spine surgery — relevant to postoperative skeletal recovery support.

PubMed ID: 30690785

Calcium/calcitriol used adjunctively to prevent hypocalcemia with denosumab in dialysis patients while BMD improved — supports bone‑related recovery during therapy.

PubMed ID: 30649176

Maternal calcium supplementation produced superior bone recovery postpartum—direct evidence for bone‑related recovery support.

PubMed ID: 31652407

Greek yogurt during high‑impact training increased bone formation markers, indicating enhanced bone turnover toward formation during remodeling/recovery.

PubMed ID: 31170812

β-TCP graft with growth factor matched autograft for fusion — direct, high-quality evidence that Ca-based graft substitutes support bone recovery.

PubMed ID: 31115592

Zoledronic acid reduced periprosthetic bone loss post-arthroplasty while Ca+calcitriol were given — supports bone recovery context with calcium adjunct.

PubMed ID: 31058448

Zoledronate with calcium/vitamin D reduced refracture rate and increased BMD in elderly fracture patients—supports bone‑related recovery as part of combined therapy.

PubMed ID: 31972958

Calcium‑containing synthetic graft promoted new bone in sockets and preserved ridge dimensions — supports bone recovery post‑extraction.

PubMed ID: 32131366

Bone-turnover marker reductions with collagen + calcium+vitD suggest potential to support bone recovery processes (biomarker evidence).

PubMed ID: 31809394

Calcium‑containing bone graft achieved similar functional recovery and radiographic healing to autograft—supports post‑operative bone recovery.

PubMed ID: 31864574

Calcium phosphate substitute led to comparable knee stability and function after staged ACL revision—evidence for bone‑related recovery.

PubMed ID: 32991652

Calcium‑phosphate grafts promoted new bone and favorable graft resorption—beneficial for post‑surgical bone recovery.

PubMed ID: 32799365

Biphasic calcium phosphate + membrane reduced socket bone loss after extraction—supports surgical bone recovery.

PubMed ID: 32080013

Calcium‑phosphate ceramic putty showed similar 1‑year fusion performance to autograft—relevant to postoperative bone recovery.

PubMed ID: 32798112

3D‑printing–assisted calcium sulfate cement grafting improved radiological/functional outcomes after calcaneal fracture—supports bone recovery.

PubMed ID: 33027800

MNT raised calcium/Vit D intake that supports bone recovery processes; evidence is behavior/nutrition change rather than clinical fracture healing data.

PubMed ID: 33047971

Surgical correction of hyperparathyroidism led to improvements in BMD and bone metabolism—evidence of bone recovery linked to calcium/PTH axis.

PubMed ID: 32796301

Biosilicate orbital implant used successfully for socket reconstruction — direct clinical evidence of bone/ socket recovery with a Ca‑bearing bioactive material.

PubMed ID: 34201328

Combined endo‑periodontal defects healed best with MTA + bone graft—supports bone-related recovery in complex dental defects.

PubMed ID: 34657018

Calcium-containing pulpotomy materials supported root maturation and clinical recovery in immature molars.

PubMed ID: 34702443

Calcitriol shortened duration of postoperative hypocalcemia after thyroidectomy—helps accelerate recovery of calcium homeostasis post‑surgery.

PubMed ID: 34269239

Biphasic calcium phosphate graft used for sinus lifts supports bone height gain and implant stability — direct bone recovery application of calcium-containing material.

PubMed ID: 33731168

Guided osteoporosis therapy including calcium improved BMD and implant migration after knee replacement — supports bone-related recovery after orthopedic surgery.

PubMed ID: 34237973

Vancomycin‑loaded calcium phosphate cement after debridement promoted bone healing and low recurrence in chronic osteomyelitis — supports bone‑related recovery using a calcium material.

PubMed ID: 33998210

CPC+rhBMP‑2 accelerated return to full weight‑bearing and reduced time to external fixator removal—strong support for bone recovery.

PubMed ID: 34040361

Resorbable calcium fillers in spinal stentoplasty produced sustained pain relief and evidence of osteogenesis—supports post‑fracture bone recovery.

PubMed ID: 34347093

TransCon PTH enabled physiologic PTH replacement and normalization of calcium handling—useful in recovery from hypoparathyroid‑related bone/metabolic issues.

PubMed ID: 36271471

Phase‑3 TransCon PTH showed marked clinical improvements (reduced supplement need, normalized urine calcium), supporting recovery of calcium/bone homeostasis.

PubMed ID: 34751787

Acute suppression of bone resorption can favor recovery/remodeling balance (indirect evidence).

PubMed ID: 35191065

BCP graft RCT showed similar hard‑tissue dimensions at 6 months—evidence that calcium‑containing grafts support local bone recovery.

PubMed ID: 36330670

Soft‑block calcium‑phosphate grafts improved ridge contour in early healing—supports bone recovery after augmentation.

PubMed ID: 36272766

Calcium phosphate putty for sternal closure improved early recovery metrics and shortened hospitalization—strong bone-recovery evidence.

PubMed ID: 35353097

Calcium phosphosilicate graft aided socket preservation and produced D3-quality bone by 6 months—supports recovery of alveolar bone.

PubMed ID: 35446950

Calcium‑based alloplast produced new vital bone for implants (ridge preservation)—supports local bone recovery after extraction/implant preparation.

PubMed ID: 35973626

Calcium sulfate beads with vancomycin reduced early PJI and sped recovery/hospital discharge—improves post‑surgical bone/implant recovery context.

PubMed ID: 36779614

Calcium‑based osteochondral implant improved structural/clinical knee outcomes over two years — strong evidence for calcium scaffold aiding bone/cartilage recovery.

PubMed ID: 36799782

Perioperative Ca+vitD prevented early hypocalcemia after thyroidectomy — supports immediate post‑op calcium homeostasis and recovery.

PubMed ID: 36825719

Calcium‑containing bone graft with PRF significantly improved radiographic bone fill and clinical attachment — relevant to bone recovery.

PubMed ID: 37314107

70/30 BCP better maintained augmented bone dimensions over 6 months — supports post‑surgical bone recovery.

PubMed ID: 36982613

BCP bone graft study directly demonstrates bone regeneration relevant to post‑surgical bone recovery.

PubMed ID: 37843657

rhBMP‑2 + calcium phosphate graft accelerated new bone formation and material resorption—relevant to recovery after extraction/socket preservation.

PubMed ID: 36833994

Vitamin D+calcium associated with improved callus formation after pediatric fractures—supports bone recovery.

PubMed ID: 38881258

Calcium phosphate ceramic produced high spinal fusion rates—strong evidence supporting bone repair and post‑surgical recovery where calcium materials were used.

PubMed ID: 39603923

Improved Ca bioavailability (citrate) is relevant to optimizing systemic Ca for bone recovery after surgery or metabolic bone stress.

PubMed ID: 39475095

Calcium silicate materials used in regenerative endodontics enabled periapical healing and return of sensibility — relevant to bone/tooth recovery.

PubMed ID: 39478364

BMP‑2 CaP graft improved early bone formation and decreased augmentation need—direct evidence for improved post-extraction/implant recovery.

PubMed ID: 38216920

Neonatal trial: continuous calcium infusion reduced MBD incidence and ALP — strong clinical evidence supporting bone mineral recovery/prevention in preterm infants.

PubMed ID: 39477477

After vertebroplasty, calcium carbonate + vitamin D (background) with salmon calcitonin produced better pain and bone‑marker improvements — supports bone recovery post‑fracture.

PubMed ID: 39533934

TCP graft + PRP reduced early crestal bone loss after implant placement — directly supports early bone recovery at surgical sites.

PubMed ID: 38797994

NIRAF identification of parathyroids reduced transient hypocalcemia after thyroidectomy, aiding early postoperative calcium recovery and reducing risk of bone/mineral complications.

PubMed ID: 38834143

Calcium chloride‑activated platelet concentrate improved radiographic socket bone formation — supports local bone healing/recovery after extraction.

PubMed ID: 40214048

Reduced vertebral fracture incidence after adrenalectomy suggests improved skeletal recovery/outcomes in that clinical context; calcium/vitamin D supported care.

PubMed ID: 39804018

Acute suppression of exercise‑induced bone resorption and PTH by pre‑exercise calcium supports mechanisms that could aid bone recovery after mechanical stress.

PubMed ID: 39861392

Calcium maltobionate reduced bone resorption and maintained bone density—useful for recovery of bone mass after loss or injury.

PubMed ID: 40388262

Very large increases in new bone formation with rhBMP‑2 on a calcium phosphate carrier — directly supports bone‑related recovery in surgical/regenerative contexts.

PubMed ID: 40155539

Calcium‑based intracanal dressings reduced mediators of bone resorption and inflammation — supports local recovery of periapical bone.

PubMed ID: 40116954

β‑TCP coated graft maintained alveolar ridge dimensions and good healing — direct bone recovery/replacement evidence.

PubMed ID: 40080289

Aragonite scaffold improved osteochondral defect fill and clinical outcomes — strong evidence for local bone/cartilage recovery.

PubMed ID: 40691703

Bioceramic apical plug accelerated radiographic healing—local bone recovery benefit.

PubMed ID: 39856505

Periodontal defect repair with Ca-phosphate cement + growth factors improved hard-tissue fill—applicable to localized bone-related recovery.

PubMed ID: 8028755

Combination therapy increased BMD and reduced bone pain and resorption markers — relevant to bone recovery after damage/osteoporosis.

PubMed ID: 17896582

AKG‑Ca notably reduced CTX, suggesting an anabolic/resorption‑reducing milieu that could support recovery after bone injury.

PubMed ID: 19165383

Large RCT: daily 1200 mg calcium in pregnancy significantly lowered maternal blood lead (up to 24% in high-compliance women)—direct pregnancy-relevant benefit.

PubMed ID: 18851852

Large RCT: high‑dose Ca (2 g/day) in low‑intake primigravidas markedly reduced pre‑eclampsia and preterm birth — direct pregnancy benefit.

PubMed ID: 18696358

Large RCT of 1.5 g Ca/day in pregnancy — direct trial of Ca supplementation during pregnancy (measured lab markers; null for platelet/urate/proteinuria).

PubMed ID: 19716540

Randomized trial in low‑calcium pregnant women showed calcium supplementation reduced fetoplacental vascular resistance — direct physiologic benefit in pregnancy.

PubMed ID: 19589154

Large survey of pregnant women in rural China found median calcium intake ~454 mg/day with ~70% below EAR—direct evidence of need for calcium in pregnancy.

PubMed ID: 20044757

Pregnant women given milk+calcium had improved maternal spine and whole-body BMD and favorable bone turnover marker changes

PubMed ID: 20554790

Randomized high‑dose calcium in low‑intake Gambian pregnant women produced major changes in maternal bone markers and hip BMC (unexpectedly lower BMC) — directly relevant to pregnancy calcium interventions though outcome was adverse.

PubMed ID: 40159712

Calcium gluconate + ergometrine reduced postpartum blood loss and improved coagulation — directly relevant to postpartum obstetric care.

PubMed ID: 40611339

Egg‑based dietary intervention in pregnant women significantly increased calcium adequacy (NAR) and overall nutrient adequacy.

PubMed ID: 40297037

Interpersonal/social education program specifically increased pregnant women's dietary calcium intake by ~160 mg/day (direct and relevant evidence).

PubMed ID: 21784309

Postpartum women given 600 mg/day Ca had increased BMD — relevant to maternal bone recovery after pregnancy and lactation.

PubMed ID: 21677054

Large maternal calcium supplementation follow‑up trial: maternal calcium given in pregnancy did not change offspring BP or CVD risk markers—directly relates to prenatal calcium supplementation context.

PubMed ID: 24163957

Randomized trial in pregnant women at risk of pre‑eclampsia: 500 mg calcium + vitamin D improved fasting glucose and triglycerides over 9 weeks—direct pregnancy supplementation data.

PubMed ID: 23131462

Randomized trial in pregnant women showed higher vitamin D (and lower maternal PTH) with higher vitamin D dosing—relevant to maternal–fetal calcium metabolism and pregnancy bone health.

PubMed ID: 23477205

Adolescent mothers received ~1000 mg Ca/day postpartum and bone mass changes were tracked—directly relevant to maternal calcium needs (postpartum).

PubMed ID: 23719547

Pregnant adolescent mothers given Ca+D had substantial spine BMD increases and less lactation-related bone loss—strong pregnancy/lactation relevance.

PubMed ID: 24210789

Randomized trial: high-dose vitamin D in pregnancy increased neonatal size and maternal weight gain—vitamin D facilitates intestinal calcium absorption relevant to pregnancy calcium needs.

PubMed ID: 23902782

Direct randomized trial of high‑dose Ca in pregnancy (1500 mg/d) with clear, sustained maternal bone effects (negative outcome for maternal BMD).

PubMed ID: 23628132

RCT in vitamin D–deficient pregnant women increased maternal and neonatal calcium — directly relevant to pregnancy calcium status and needs.

PubMed ID: 23474270

Dietary survey showing a substantial fraction of pregnant women below the calcium EAR—directly relevant to pregnancy calcium supplementation needs.

PubMed ID: 25511814

Large RCT: daily calcium during pregnancy lowered bone resorption markers and improved a bone surrogate in compliant women—direct evidence for pregnancy benefits to maternal bone.

PubMed ID: 25411294

Pregnancy crossover trial showing enteric‑coated calcium granules had dramatically lower absorption—directly relevant to supplement formulation and maternal calcium supply.

PubMed ID: 24728212

Pilot RCT: 2 g/day calcium plus aspirin in high-risk hypertensive pregnant women produced sizable (but statistically nonsignificant) reductions in preeclampsia and fetal growth restriction — directly pregnancy-relevant.

PubMed ID: 25332469

Shows dietary calcium inhibits iron absorption from fortified milk in children but ascorbic acid compensates—important practical interaction for pregnant women needing iron and calcium.

PubMed ID: 25790761

Calcium+vitamin D in women with gestational diabetes reduced C‑section rates, hospital stays and newborn macrosomia — clinically relevant pregnancy benefit (combined supplement).