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Calcium and Folic Acid: study protocols

8 study groups took Calcium together with Folic Acid. These are the doses the studies gave. They are not a recommendation.

Calcium: what the research found →

Dose per serving from research: Calcium

8 study groups in 4 studies say how much Calcium participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 g to 2.5 g, 38% of 8 study groups.

Daily doseStudy groups
100 mg to 250 mg
2
250 mg to 500 mg
1
500 mg to 1 g
2
1 g to 2.5 g
3

Dose per serving from research: Folic Acid

6 study groups in 3 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 100% of 6 study groups.

Daily doseStudy groups
250 mcg to 500 mcg
6

Commonly used together

8 of 8 study groups took Calcium and Folic Acid with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Iron
7

8 study groups

Study
Integrating Calcium Into Antenatal Iron-Folic Acid Supplementation in Ethiopia: Women's Experiences, Perceptions of Acceptability, and Strategies to Support Calcium Supplement Adherence
2020 · 3-event regimen · Healthy pregnant women aged 16 years or older, 12–28 weeks’ gestation, in rural Ethiopia
1.5 g400 mcg6 weeks17
Integrating Calcium Into Antenatal Iron-Folic Acid Supplementation in Ethiopia: Women's Experiences, Perceptions of Acceptability, and Strategies to Support Calcium Supplement Adherence
2020 · 2-event regimen · Healthy pregnant women aged 16 years or older, 12–28 weeks’ gestation, in rural Ethiopia
1 g400 mcg6 weeks16
Integrating Calcium Into Antenatal Iron-Folic Acid Supplementation in Ethiopia: Women's Experiences, Perceptions of Acceptability, and Strategies to Support Calcium Supplement Adherence
2020 · 4-event regimen · Healthy pregnant women aged 16 years or older, 12–28 weeks’ gestation, in rural Ethiopia
1.5 g400 mcg6 weeks15
One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans
2015 · B-vitamin supplementation · Older German adults, mean age 67 years
456 mg500 mcg1 year—
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
150 mg400 mcg—870
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · control · Women planning pregnancy; generally healthy, recruited before conception
150 mg400 mcg—859
A Simplified Regimen Compared with WHO Guidelines Decreases Antenatal Calcium Supplement Intake for Prevention of Preeclampsia in a Cluster-Randomized Noninferiority Trial in Rural Kenya
2017 · standard regimen · Pregnant women enrolled between 16 and 30 weeks of gestation
1.5 g—8 weeks—
A Simplified Regimen Compared with WHO Guidelines Decreases Antenatal Calcium Supplement Intake for Prevention of Preeclampsia in a Cluster-Randomized Noninferiority Trial in Rural Kenya
2017 · low-dose regimen · Pregnant women enrolled between 16 and 30 weeks of gestation
1 g—8 weeks—
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