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Calcium and Magnesium: study protocols

25 study groups took Calcium together with Magnesium. These are the doses the studies gave. They are not a recommendation.

Calcium: what the research found →

Dose per serving from research: Calcium

23 study groups in 18 studies say how much Calcium participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 g to 2.5 g, 52% of 23 study groups.

Daily doseStudy groups
250 mg or less
1
250 mg to 500 mg
3
500 mg to 1 g
7
1 g to 2.5 g
12

Dose per serving from research: Magnesium

21 study groups in 16 studies say how much Magnesium participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 mg to 250 mg, 38% of 21 study groups.

Daily doseStudy groups
50 mg or less
1
50 mg to 100 mg
7
100 mg to 250 mg
8
250 mg to 500 mg
2
500 mg to 1 g
3

Commonly used together

17 of 25 study groups took Calcium and Magnesium with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Vitamin D
8
Zinc
7

25 study groups

Study
Gaviscon Double Action Liquid (antacid & alginate) is more effective than antacid in controlling post-prandial oesophageal acid exposure in GERD patients: a double-blind crossover study
2014 · CVS Antacid Supreme · Adults with GERD symptoms and a history of LA A or B esophagitis and/or abnormal pH monitoring
400 mg135 mg1 day—
A Multi-Mineral Intervention to Modulate Colonic Mucosal Protein Profile: Results from a 90-Day Trial in Human Subjects
2021 · Aquamin® · Men and non-pregnant/non-lactating women aged 18–80 years in general good health but at increased risk for colorectal cancer
800 mg—90 days10
Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause
2006 · ES (Estromineral serena) · Symptomatic menopausal women with sleep or mood alterations
141 mg50 mg24 weeks44
Magnesium-Zinc-Calcium-Vitamin D Co-supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial
2018 · Magnesium-zinc-calcium-vitamin D co-supplementation · Women with polycystic ovary syndrome (PCOS); age not reported
800 mg200 mg12 weeks30
Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial
2017 · Control · Postmenopausal women with osteopenia; age range not stated
1.2 g550 mg1 year—
Effect on blood pressure of potassium, calcium, and magnesium in women with low habitual intake
1998 · all three minerals together · Normotensive women, mean age 39, with low habitual intake of potassium, calcium, and magnesium
30 mmol14 mmol16 weeks—
Effect of lactulose on calcium and magnesium absorption: a study using stable isotopes in adult men
2007 · low-dose lactulose (2 g) · 24 healthy adult men
300 mg150 mg1 day24
Effect of lactulose on calcium and magnesium absorption: a study using stable isotopes in adult men
2007 · high-dose lactulose (4 g) · 24 healthy adult men
300 mg150 mg1 day24
[Vitrum osteomag in prevention of osteoporosis in postmenopausal women: results of the comparative open multicenter trial]
2004 · Group 1: Vitrum Osteomag · Postmenopausal women with osteopenia; age range not reported
1.2 g80 mg1 year125
Calcium and vitamin D fortified milk reduces bone turnover and improves bone density in postmenopausal women over 1 year
2018 · intervention · Chinese postmenopausal women in Malaysia; mean age 59 years
1.2 g96 mg1 year61
Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial
2017 · RCE · Postmenopausal women with osteopenia; age range not stated
1.2 g550 mg1 year—
Negative balance of calcium and magnesium under relatively low sodium intake in humans
2003 · Relatively low sodium intake with adequate calcium and magnesium intake · Six female students; ages and health status not reported
800 mg280 mg10 days6
Small bowel absorption of magnesium and calcium sulphate from a natural mineral water in subjects with ileostomy
2006 · High-mineral-content natural mineral water · Six subjects with ileostomy
6.9 mmol2.3 mmol2 days6
Impact of supplementary high calcium milk with additional magnesium on parathyroid hormone and biochemical markers of bone turnover in postmenopausal women
2002 · milk group · Healthy postmenopausal women
1.2 g106 mg4 weeks25
Acute effect of high-calcium milk with or without additional magnesium, or calcium phosphate on parathyroid hormone and biochemical markers of bone resorption
2003 · HCSM with 65.5 mg magnesium · Healthy postmenopausal women
1.2 g65.5 mg1 day21
Acute effect of high-calcium milk with or without additional magnesium, or calcium phosphate on parathyroid hormone and biochemical markers of bone resorption
2003 · HCSM with 172 mg magnesium · Healthy postmenopausal women
1.2 g172 mg1 day21
A Calcium-Rich Multimineral Intervention to Modulate Colonic Microbial Communities and Metabolomic Profiles in Humans: Results from a 90-Day Trial
2020 · Aquamin · Adults aged 20–66, male or nonpregnant female, in general good health but at increased risk for colon cancer
800 mg—90 days10
MgCaCO3 versus CaCO3 in peritoneal dialysis patients--a cross-over pilot trial
2015 · MgCaCO3 group · Adults with peritoneal dialysis
1.14 g965 mg90 days—
Magnesium carbonate as a phosphorus binder: a prospective, controlled, crossover study
1996 · MgCO3 plus half the usual dose of CaCO3 · Chronic hemodialysis patients
1.2 g465 mg——
A Trial on The Effects of Magnesium-Zinc-Calcium-Vitamin D Co-Supplementation on Glycemic Control and Markers of Cardio-Metabolic Risk in Women with Polycystic Ovary Syndrome
2017 · Magnesium-zinc-calcium-vitamin D co-supplementation · Women with polycystic ovary syndrome (PCOS)
800 mg200 mg12 weeks30
The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes
2019 · Magnesium-zinc-calcium-vitamin D group · Women aged 18–40 with gestational diabetes mellitus, at 24–28 weeks’ gestation at diagnosis
800 mg200 mg6 weeks30
Activation of the calcium sensing receptor stimulates gastrin and gastric acid secretion in healthy participants
2009 · cinacalcet group · Healthy men and postmenopausal women aged 45–70 years
1.2 g100 mg11 days9
Activation of the calcium sensing receptor stimulates gastrin and gastric acid secretion in healthy participants
2009 · placebo group · Healthy men and postmenopausal women aged 45–70 years
1.2 g100 mg11 days8
Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women
2016 · Intervention (Int), premenopausal women · Premenopausal women, mean age 41 years; no specific condition stated
1 g96 mg12 weeks—
Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women
2016 · Intervention (Int), postmenopausal women · Postmenopausal women, mean age 59 years; no specific condition stated
1.2 g96 mg12 weeks—
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