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Calcium and Vitamin K: study protocols

25 study groups took Calcium together with Vitamin K. These are the doses the studies gave. They are not a recommendation.

Calcium: what the research found →

Dose per serving from research: Calcium

25 study groups in 19 studies say how much Calcium participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mg to 1 g, 76% of 25 study groups.

Daily doseStudy groups
250 mg to 500 mg
5
500 mg to 1 g
19
over 1 g
1

Dose per serving from research: Vitamin K

23 study groups in 17 studies say how much Vitamin K participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mcg to 100 mcg, 35% of 23 study groups.

Daily doseStudy groups
10 mcg or less
1
10 mcg to 25 mcg
2
25 mcg to 50 mcg
0
50 mcg to 100 mcg
8
100 mcg to 250 mcg
5
250 mcg to 500 mcg
2
500 mcg to 1 mg
2
1 mg to 2.5 mg
0
2.5 mg to 5 mg
0
5 mg to 10 mg
0
10 mg to 25 mg
0
25 mg to 50 mg
3

Commonly used together

21 of 25 study groups took Calcium and Vitamin K with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Vitamin D
18

25 study groups

Study
A smartphone application to improve adherence to vitamin and mineral supplementation after bariatric surgery
2022 · Intervention group · Adults aged over 18 to 60 years undergoing gastric bypass or sleeve gastrectomy
1 g75 mcg1 year71
A smartphone application to improve adherence to vitamin and mineral supplementation after bariatric surgery
2022 · Control group · Adults aged over 18 to 60 years undergoing gastric bypass or sleeve gastrectomy
1 g75 mcg1 year69
Menatetrenone versus alfacalcidol in the treatment of Chinese postmenopausal women with osteoporosis: a multicenter, randomized, double-blinded, double-dummy, positive drug-controlled clinical trial
2014 · Group M (menatetrenone) · Women aged 45–75 years, postmenopausal for at least 5 years, with osteoporosis
500 mg45 mg1 year118
Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in Korean postmenopausal women over sixty-years-old
2011 · treatment group (vitamin K) · Postmenopausal Korean women over 60 years old
630 mg45 mg26 weeks40
Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia
2006 · vitamin K2 group · Postmenopausal women with osteoporosis
1.5 g45 mg48 weeks33
Possible site-specific effect of an intervention combining nutrition and lifestyle counselling with consumption of fortified dairy products on bone mass: the Postmenopausal Health Study II
2011 · CaDK1 group · Postmenopausal women
800 mg100 mcg1 year26
Possible site-specific effect of an intervention combining nutrition and lifestyle counselling with consumption of fortified dairy products on bone mass: the Postmenopausal Health Study II
2011 · CaDK2 group · Postmenopausal women
800 mg100 mcg1 year24
Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women
2007 · combined vitamins K1 and D3 plus calcium · Healthy, nonosteoporotic Scottish women aged 60 years or older
1 g200 mcg2 years—
Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study
2020 · Co-supplementation group · Community-dwelling men and postmenopausal women aged 50–75 years
500 mg—1 year—
The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-year randomized, placebo-controlled clinical trial
2021 · vitamin K2 (MK-7) group · Postmenopausal women with osteopenia
800 mg375 mcg1096 days—
Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study
2013 · geniVida bone blend (GBB) · Healthy postmenopausal women aged 45–55 years, 1–3 years since their last spontaneous menstrual bleeding
500 mg150 mcg26 weeks31
Effect of phylloquinone (vitamin K1) supplementation for 12 months on the indices of vitamin K status and bone health in adult patients with Crohn's disease
2014 · 1000 μg vitamin K/d plus calcium and vitamin D3 group (main RCT) · Adults with Crohn's disease, currently in remission
500 mg1 mg1 year43
The effects of vitamin D, K and calcium co-supplementation on carotid intima-media thickness and metabolic status in overweight type 2 diabetic patients with CHD
2016 · vitamin D, vitamin K and calcium supplements · Overweight patients with type 2 diabetes and CHD; age and sex not specified
1 g180 mcg12 weeks33
Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: A randomized intervention trial
2016 · HD/HK · Postmenopausal women aged 50–65 years
1 g23.1 mcg12 weeks31
Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: A randomized intervention trial
2016 · HD/LK · Postmenopausal women aged 50–65 years
1 g1.37 mcg12 weeks31
The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in Vitamin D-Deficient Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
2016 · vitamin D-K-calcium co-supplementation group · Vitamin D-deficient women aged 18–40 years with polycystic ovary syndrome
1 g180 mcg8 weeks30
Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: A randomized intervention trial
2016 · LD/HK · Postmenopausal women aged 50–65 years
1 g23.1 mcg12 weeks30
The Effects of Calcium, Vitamins D and K co-Supplementation on Markers of Insulin Metabolism and Lipid Profiles in Vitamin D-Deficient Women with Polycystic Ovary Syndrome
2017 · calcium, vitamin D and vitamin K group · Women aged 18–40 years with vitamin D deficiency and polycystic ovary syndrome
1 g180 mcg8 weeks28
Effect of calcium, vitamins K1 and D3 on bone in galactosemia
2006 · calcium, vitamins K1 and D3 supplementation · Children aged 3–17 years with classical galactosemia
750 mg1 mg2 years—
Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in premenopausal women
2006 · High calcium skim milk with added phylloquinone · Premenopausal women aged 20 to 35 years
1 g80 mcg16 weeks—
Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone
2012 · menatetrenone group · Children receiving long-term glucocorticoids
400 mg—1 year—
Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women: a randomized controlled trial
2021 · MK-7 group · Postmenopausal women; the abstract describes them as healthy
800 mg375 mcg1 year—
Osteocalcin carboxylation is not associated with body weight or percent fat changes during weight loss in post-menopausal women
2015 · Caloric restriction-only group (CR) · Sedentary post-menopausal women aged 50–70 years with overweight or obesity (BMI 25–40 kg/m²)
1 g80 mcg20 weeks—
Osteocalcin carboxylation is not associated with body weight or percent fat changes during weight loss in post-menopausal women
2015 · Moderate-intensity exercise group · Sedentary post-menopausal women aged 50–70 years with overweight or obesity (BMI 25–40 kg/m²)
1 g80 mcg20 weeks—
Osteocalcin carboxylation is not associated with body weight or percent fat changes during weight loss in post-menopausal women
2015 · Vigorous-intensity exercise group · Sedentary post-menopausal women aged 50–70 years with overweight or obesity (BMI 25–40 kg/m²)
1 g80 mcg20 weeks—
Calcium and Vitamin K: study protocols | supp.fit