Calcium and Vitamin D3: study protocols
10 study groups took Calcium together with Vitamin D3. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Calcium
10 study groups in 5 studies say how much Calcium participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 50% of 10 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mg to 500 mg | 5 |
| 500 mg to 1 g | 2 |
| 1 g to 2.5 g | 3 |
Dose per serving from research: Vitamin D3
8 study groups in 4 studies say how much Vitamin D3 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 100 IU to 250 IU and 250 IU to 500 IU and 500 IU to 1,000 IU and 1,000 IU to 2,500 IU, 25% of 8 study groups each.
| Daily dose | Study groups |
|---|---|
| 100 IU to 250 IU | 2 |
| 250 IU to 500 IU | 2 |
| 500 IU to 1,000 IU | 2 |
| 1,000 IU to 2,500 IU | 2 |
Commonly used together
3 of 10 study groups took Calcium and Vitamin D3 with something else, but nothing that 3 or more different studies gave.
10 study groups
| Study | ||||
|---|---|---|---|---|
| Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy 2024 · India trial, 500-mg group · Adults aged 18 years or older who were nulliparous and pregnant at less than 20 weeks’ gestation | 500 mg | 250 IU | — | — |
| Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy 2024 · India trial, 1500-mg group · Adults aged 18 years or older who were nulliparous and pregnant at less than 20 weeks’ gestation | 1.5 g | 250 IU | — | — |
| The Effect of the Modified Eighth Section of Eight-Section Brocade on Osteoporosis in Postmenopausal Women: A Prospective Randomized Trial 2015 · Ca alone · Postmenopausal women aged 50–75 with inadequate bone mass or osteoporosis | 1.5 g | 600 IU | 1 year | 50 |
| The Effect of the Modified Eighth Section of Eight-Section Brocade on Osteoporosis in Postmenopausal Women: A Prospective Randomized Trial 2015 · MESE + Ca · Postmenopausal women aged 50–75 with inadequate bone mass or osteoporosis | 1.5 g | 600 IU | 1 year | 50 |
| The joint effect of energy reduction with calcium supplementation on the risk factors of type 2 diabetes in the overweight population: a two-year randomized controlled trial 2021 · energy-reduction with calcium supplementation group (ER-CSG) · Overweight adults aged 20–70 with low dietary calcium intake and no major disease; received dietary energy-reduction education as well as supplements | 400 mg | — | 2 years | 300 |
| The joint effect of energy reduction with calcium supplementation on the risk factors of type 2 diabetes in the overweight population: a two-year randomized controlled trial 2021 · calcium supplementation group (CSG) · Overweight adults aged 20–70 with low dietary calcium intake and no major disease | 400 mg | — | 2 years | 298 |
| One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans 2015 · Vitamin D3 plus calcium carbonate · Older German adults, mean age 67 years | 456 mg | 1,200 IU | 1 year | — |
| One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans 2015 · B-vitamin supplementation · Older German adults, mean age 67 years | 456 mg | 1,200 IU | 1 year | — |
| Potassium Bicarbonate Supplementation Lowers Bone Turnover and Calcium Excretion in Older Men and Women: A Randomized Dose-Finding Trial 2015 · Low-dose KHCO3 group · Healthy ambulatory men and postmenopausal women aged 60 years and older | 600 mg | 500 IU | 12 weeks | — |
| Potassium Bicarbonate Supplementation Lowers Bone Turnover and Calcium Excretion in Older Men and Women: A Randomized Dose-Finding Trial 2015 · High-dose KHCO3 group · Healthy ambulatory men and postmenopausal women aged 60 years and older | 600 mg | 500 IU | 12 weeks | — |