Riboflavin and Vitamin B12: study protocols
12 study groups took Riboflavin together with Vitamin B12. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Riboflavin
12 study groups in 9 studies say how much Riboflavin participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 58% of 12 study groups.
| Daily dose | Study groups |
|---|---|
| 500 mcg or less | 1 |
| 500 mcg to 1 mg | 0 |
| 1 mg to 2.5 mg | 7 |
| 2.5 mg to 5 mg | 2 |
| 5 mg to 10 mg | 0 |
| 10 mg to 25 mg | 2 |
Dose per serving from research: Vitamin B12
12 study groups in 9 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mcg to 2.5 mcg and 2.5 mcg to 5 mcg and 5 mcg to 10 mcg, 25% of 12 study groups each.
| Daily dose | Study groups |
|---|---|
| 1 mcg or less | 1 |
| 1 mcg to 2.5 mcg | 3 |
| 2.5 mcg to 5 mcg | 3 |
| 5 mcg to 10 mcg | 3 |
| 10 mcg to 25 mcg | 0 |
| 25 mcg to 50 mcg | 2 |
Commonly used together
12 of 12 study groups took Riboflavin and Vitamin B12 with something else. Shown: what 3 or more different studies gave. The 10 most common of 12.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Vitamin B6 | 11 |
| Folic Acid | 10 |
| Thiamine | 7 |
| Iron | 6 |
| Vitamin D | 6 |
| Vitamin E | 5 |
| Zinc | 5 |
| Vitamin A | 4 |
| Vitamin C | 4 |
| Copper | 3 |
12 study groups
| Study | ||||
|---|---|---|---|---|
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 1.8 mg | 2.6 mcg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women | 20 mg | 50 mcg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin without vitamin A · HIV-positive pregnant Tanzanian women | 20 mg | 50 mcg | — | — |
| A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status 2022 · B-vitamin treatment · Community-dwelling adults aged 50 years or older; men and women; no specific diagnosed condition, and not currently taking B-vitamin supplements at screening | 5 mg | 10 mcg | 2 years | 103 |
| Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial 2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception | 1.8 mg | 5.2 mcg | — | 870 |
| Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B(12) status among young Laotian children: a randomized controlled trial 2022 · micronutrient powder group (MNP) · Children aged 6–23 months in rural Lao PDR; no disease-based selection, with high prevalence of undernutrition and micronutrient deficiencies | 500 mcg | 0.9 mcg | 36 weeks | 130 |
| Fortified breakfast cereal consumed daily for 12 wk leads to a significant improvement in micronutrient intake and micronutrient status in adolescent girls: a randomised controlled trial 2016 · Fortified cereal, morning · Females aged 16–19 years who regularly skipped breakfast and had low riboflavin status and haemoglobin; no diagnosed illness | 1.71 mg | 1.45 mcg | 12 weeks | 18 |
| Fortified breakfast cereal consumed daily for 12 wk leads to a significant improvement in micronutrient intake and micronutrient status in adolescent girls: a randomised controlled trial 2016 · Fortified cereal, evening · Females aged 16–19 years who regularly skipped breakfast and had low riboflavin status and haemoglobin; no diagnosed illness | 1.71 mg | 1.45 mcg | 12 weeks | 16 |
| A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia 2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population | 1.4 mg | 2.6 mcg | 12 weeks | 105 |
| A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia 2019 · drink powder · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population | 2.8 mg | 5.2 mcg | 12 weeks | 93 |