Turmeric
19 benefits mapped to clinical evidence across supplements.
Dose per serving from products
4,442 products in our catalogue print how much Turmeric a serving holds.
Most common: 50 mg to 100 mg, 21% of 4,442 products.
| Dose per serving | Products |
|---|---|
| 10 mg or less | 192 |
| 10 mg to 25 mg | 669 |
| 25 mg to 50 mg | 741 |
| 50 mg to 100 mg | 932 |
| 100 mg to 250 mg | 814 |
| 250 mg to 500 mg | 526 |
| 500 mg to 1 g | 395 |
| over 1 g | 173 |
Dose per serving from research
67 study groups in 48 studies say how much Turmeric participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mg to 1 g, 25% of 67 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mg or less | 4 |
| 100 mg to 250 mg | 4 |
| 250 mg to 500 mg | 12 |
| 500 mg to 1 g | 17 |
| 1 g to 2.5 g | 16 |
| 2.5 g to 5 g | 10 |
| 5 g to 10 g | 3 |
| over 10 g | 1 |
Commonly used together
24 of 67 study groups took Turmeric with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Piperine | 4 |
| Curcumin | 3 |
| Glucosamine | 3 |
Benefit Evidence
Research sources
Inflammation (41)
- Ability of curcuminoid compared to diclofenac sodium in reducing the secretion of cycloxygenase-2 enzyme by synovial fluid's monocytes of patients with osteoarthritis
PubMed ID: 22745140
Curcuminoids reduced COX‑2 secretion by synovial monocytes similarly to diclofenac in OA patients (human biochemical evidence).
- Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis
PubMed ID: 19678780
Knee OA trial showed similar efficacy to ibuprofen for pain/function — clinical anti-inflammatory/analgesic effect in OA context.
- Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial
PubMed ID: 23242572
Curcuma extract improved OA clinical outcomes, consistent with anti‑inflammatory action (human RCT).
- A Triple-blind randomized controlled trial on the effects of turmeric versus ginger on inflammatory biomarkers in patients with COVID-19
PubMed ID: 40841392
Turmeric lowered CRP and ESR in mild COVID‑19 outpatients (short‑term inflammatory biomarker reductions).
- A Hot Water Extract of Curcuma longa L. Improves Fasting Serum Glucose Levels in Participants with Low-Grade Inflammation: Reanalysis of Data from Two Randomized, Double-Blind, Placebo-Controlled Trials
PubMed ID: 36145139
Pooled reanalysis: Curcuma water extract lowered hsCRP in participants with low‑grade inflammation — strong anti‑inflammatory signal in that subgroup.
- Curcumin supplementation improves the clinical outcomes of patients with diabetes and atherosclerotic cardiovascular risk
PubMed ID: 40759997
Diabetes trial showed lowered TNF‑α and improved inflammatory profile with curcumin (open‑label but clinically relevant).
- Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
PubMed ID: 40573083
Consistent, clinically significant reductions in TNF, IL‑1β and IL‑6 over 12 months in a well‑powered RCT.
- The effects of curcumin supplementation on inflammatory markers in systemic lupus erythematosus patients: a randomized placebo-controlled trial
PubMed ID: 39546036
SLE RCT decreased IL-6 and anti-dsDNA antibodies—disease-relevant anti-inflammatory/immunomodulatory results.
- The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
PubMed ID: 39125322
12‑month trial showed reductions in inflammatory markers alongside vascular and metabolic improvements.
- Significant immunomodulatory properties of curcumin in patients with osteoarthritis; a successful clinical trial in Iran
PubMed ID: 32540725
OA trial showed decreased CRP and symptom improvement indicating anti‑inflammatory action.
- Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial
PubMed ID: 32147075
NAFLD trial demonstrated decreases in TNF‑α and MCP‑1 with curcuminoids.
- Impact of curcumin supplementation on expression of inflammatory transcription factors in hemodialysis patients: A pilot randomized, double-blind, controlled study
PubMed ID: 32204978
Hemodialysis RCT showed decreased NF‑κB expression and hsCRP after curcumin.
- Efficacy of curcuminoids for reducing postoperative pain after laparoscopic gynecologic surgery: A pilot randomized trial
PubMed ID: 31150356
Postoperative pain reductions with curcuminoids are consistent with acute anti-inflammatory/analgesic effects.
- The Neuromodulatory Effects of ω-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms
PubMed ID: 30760195
Nano-curcumin + omega-3 downregulated COX-2/iNOS gene expression and serum levels — molecular anti-inflammatory effect with clinical benefit.
- The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial
PubMed ID: 30864188
Lowered hs-CRP in T2D patients — modest anti-inflammatory biomarker change.
- A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study
PubMed ID: 28850308
RA RCT with bioavailable curcumin reduced CRP/ESR and improved disease activity scores.
- Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus
PubMed ID: 29299989
T2D RCT produced a significant decrease in TNF‑α and favorable adipokine changes, indicating anti‑inflammatory effects.
- Effects of curcumin on crevicular levels of IL-1β and CCL28 in experimental gingivitis
PubMed ID: 26219195
Topical curcumin blunted IL‑1β and CCL28 increases in experimental gingivitis—local anti‑inflammatory effects.
- Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial
PubMed ID: 25688638
OA trial showed reductions in oxidative stress/inflammatory-related markers (MDA) with curcuminoids.
- Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis
PubMed ID: 25618800
Curcumin+piperine RCT in metabolic syndrome lowered CRP significantly—strong anti‑inflammatory biomarker evidence.
- Short-term Curcuminoid Supplementation for Chronic Pulmonary Complications due to Sulfur Mustard Intoxication: Positive Results of a Randomized Double-blind Placebo-controlled Trial
PubMed ID: 25268878
Curcuminoids reduced IL-6 and hs-CRP and improved spirometry in chronic lung injury—clear anti-inflammatory effects.
- Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study
PubMed ID: 21627399
Diabetic nephropathy RCT showed reductions in proteinuria and pro-fibrotic/inflammatory markers (TGF-β, IL-8) with turmeric.
- Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting
PubMed ID: 22481014
Perioperative curcuminoids lowered CRP and other inflammatory markers and reduced MI incidence in a RCT.
- Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis - a randomized, placebo-controlled, pilot study
PubMed ID: 24011514
Curcumin enema reduced clinical and endoscopic inflammation in distal UC per‑protocol analysis (pilot RCT).
- Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study
PubMed ID: 24672232
Curcuma domestica extract produced OA symptomatic improvement comparable to ibuprofen, suggesting anti‑inflammatory effect.
- Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial
PubMed ID: 24648302
Bioavailability-boosted curcuminoids RCT reduced TNF-α and hs-CRP significantly in cancer patients—strong anti-inflammatory human data.
- Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial
PubMed ID: 17101300
Adjunct curcumin decreased relapse and improved clinical/endoscopic indices in UC, indicating anti-inflammatory effects in the gut.
- The effect of turmeric-Boswellia formulation (Rhuleave-K) in posture-related low back soreness and discomfort: A randomized double blinded placebo controlled trial
PubMed ID: 39973246
Turmeric‑Boswellia product produced rapid pain relief likely associated with reduced inflammation (combination product evidence).
- Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study
PubMed ID: 32678677
Combination product with curcumin produced large reductions in IL‑1β and IL‑6 vs comparator.
- The dose-response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise-induced muscle damage in males
PubMed ID: 40781899
Dose‑dependent reductions in IL‑6 and oxidative stress markers after exercise with hydrolysed curcumin (inflammatory biomarker evidence).
- Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial
PubMed ID: 34774052
hsCRP decreased at week 12 vs placebo (significant at timepoint), indicating reduced low‑grade inflammation.
- Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol
PubMed ID: 33516238
Large RCT found turmeric lowered TNF‑α more than paracetamol (demonstrated anti‑inflammatory biomarker effect).
- Hot Water Extract of Curcuma longa L. Improves Serum Inflammatory Markers and General Health in Subjects with Overweight or Prehypertension/Mild Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 31394768
Consistent reductions in hsCRP, TNF-α and IL‑6 over 12 weeks — strong RCT evidence of anti-inflammatory effects.
- Herbal formulation "turmeric extract, black pepper, and ginger" versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial
PubMed ID: 32180294
Turmeric+black pepper+ginger lowered PGE2 similarly to naproxen in knee OA — powerful biochemical anti-inflammatory signal.
- Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis
PubMed ID: 24002213
Curcuma+Boswellia OA study improved symptoms versus celecoxib — anti‑inflammatory mechanism likely contributory.
- Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study
PubMed ID: 29316908
OA trial of curcumin+boswellia produced meaningful clinical improvements consistent with anti‑inflammatory action.
- Efficacy and safety evaluation of Boswellia serrata and Curcuma longa extract combination in the management of chronic lower back pain: A randomised, double-blind, placebo-controlled clinical study
PubMed ID: 39700654
Boswellia+Curcuma combo reduced TNF‑α, IL‑6 and hs‑CRP in a 90‑patient RCT (combination limits turmeric‑only attribution but shows anti‑inflammatory effect).
- Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot, Randomized Controlled Trial
PubMed ID: 32749918
One‑week formulation slightly lowered hsCRP versus placebo along with pain reduction.
- Turmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver Diseases
PubMed ID: 28443702
NAFLD RCT lowered leptin and improved insulin resistance, consistent with reduced systemic inflammatory/metabolic stress.
- Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial
PubMed ID: 27761693
Knee OA RCT showed significant reductions in IL‑1β and oxidative/inflammatory markers concomitant with symptom relief.
- Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial
PubMed ID: 24482090
Uremic pruritus RCT showed symptom reduction and decreased hs‑CRP with turmeric—clinical and inflammatory marker improvement.
Daily comfort (31)
- Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis
PubMed ID: 19678780
Knee OA study showed symptomatic improvement comparable to ibuprofen — supports general comfort/pain relief in OA.
- Black Turmeric and Aloe Vera in the Management of Oral Submucous Fibrosis: A Prospective Clinical Study
PubMed ID: 34967575
Large reduction in burning sensation in oral submucous fibrosis (symptomatic relief).
- Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study
PubMed ID: 1943180
Multi-herb OA trial reduced pain and disability vs placebo — clinical comfort benefit though product was multi-ingredient.
- Bioenhancer Assessment of Black Pepper with Turmeric on Self-Reported Pain Ratings in Adults: A Randomized, Cross-Over, Clinical Trial
PubMed ID: 41599836
Culinary turmeric doses reduced self‑reported chronic pain over 3 weeks (real‑world comfort signal).
- Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study
PubMed ID: 29316908
Curcumin+boswellia trial improved pain and functional tests in OA, supporting symptomatic comfort.
- Efficacy of high-dissolution turmeric-sesame formulation for pain relief in adult subjects with acute musculoskeletal pain compared to acetaminophen: A randomized controlled study
PubMed ID: 32664057
Proprietary turmeric blend reduced acute musculoskeletal pain and improved affective pain domain.
- Fast pain relief in exercise-induced acute musculoskeletal pain by turmeric-boswellia formulation: A randomized placebo-controlled double-blinded multicentre study
PubMed ID: 36107505
Turmeric–boswellia formulation provided rapid and large analgesia for exercise‑related pain (multi‑ingredient).
- Efficacy and safety evaluation of Boswellia serrata and Curcuma longa extract combination in the management of chronic lower back pain: A randomised, double-blind, placebo-controlled clinical study
PubMed ID: 39700654
Combination product reduced pain and disability in chronic low back pain—meaningful comfort improvement.
- The effect of turmeric-Boswellia formulation (Rhuleave-K) in posture-related low back soreness and discomfort: A randomized double blinded placebo controlled trial
PubMed ID: 39973246
Turmeric‑Boswellia formula caused large, rapid reductions in pain/disability over 15 days (comfort benefit; combination product).
- Analgesic Efficacy of Bromelain and Bromelain Plus Turmeric for Pain Control After Orthodontic Separator Placement: A Triple-Blind Randomized Clinical Trial
PubMed ID: 40260785
Bromelain with/without turmeric reduced orthodontic pain more than ibuprofen at 2–6 h (short‑term comfort benefit in a combination product).
- A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III
PubMed ID: 28679180
Rectal curcumin+calendula improved pain, urinary flow and sexual function in chronic prostatitis—symptomatic comfort benefits though small sample and combo product.
- Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study
PubMed ID: 21671126
Perioperative turmeric reduced postoperative pain, fatigue and substantially lowered analgesic use — strong evidence for symptomatic comfort after surgery.
- A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study
PubMed ID: 28850308
RA trial improved pain and disease activity leading to better patient comfort.
- The efficacy of curcumin in managing acute inflammation pain on the post-surgical removal of impacted third molars patients: A randomised controlled trial
PubMed ID: 29908031
Curcumin reduced acute postoperative pain more than an NSAID after third molar removal — clinically meaningful analgesic/comfort benefit.
- Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study
PubMed ID: 31351488
Bio-optimized turmeric reduced knee pain and analgesic use — contributes to patient comfort.
- Efficacy of curcuminoids for reducing postoperative pain after laparoscopic gynecologic surgery: A pilot randomized trial
PubMed ID: 31150356
Postoperative curcuminoids lowered pain scores at 24 and 72 hours after laparoscopic gynecologic surgery — clear comfort support.
- Curcumin ameliorates health-related quality of life in patients with liver cirrhosis: A randomized, double-blind placebo-controlled trial
PubMed ID: 32147077
Broad improvements in quality‑of‑life and symptom scores in cirrhosis indicate comfort benefit.
- Randomized, double-blind, placebo-controlled clinical trial studying the effects of Turmeric in combination with mefenamic acid in patients with primary dysmenorrhoea
PubMed ID: 32585392
Turmeric + mefenamic acid produced greater dysmenorrhea pain relief than either alone, supporting symptomatic comfort.
- Effects of nanomicelle curcumin capsules on prevention and treatment of oral mucosits in patients under chemotherapy with or without head and neck radiotherapy: a randomized clinical trial
PubMed ID: 34521398
Reduction in oral mucositis severity and pain implies symptomatic comfort benefits.
- Curcuma longa Linn versus omeprazole in treatment of functional dyspepsia: A randomized, double-blind, placebo-controlled trial
PubMed ID: 34652861
Improved dyspepsia pain and non‑pain symptoms — symptomatic comfort for GI discomfort.
- A Randomized, Placebo-Controlled Study to Evaluate the Effect of Bio-Enhanced Turmeric Formulation on Radiation-Induced Oral Mucositis
PubMed ID: 34161952
Marked reductions in severe mucositis, pain and dysphagia show strong symptomatic/comfort effects.
- Efficacy of Curcuminoids in Managing Postoperative Pain after Total Laparoscopic Hysterectomy: A Randomized Controlled, Open-Label Trial
PubMed ID: 34986477
Curcuminoid supplementation reduced postoperative pain at 72 h versus control in an open‑label trial.
- Adjunctive curcumin nano-micelles reduce overall pruritus intensity in refractory post-burn pruritus: A randomized controlled trial
PubMed ID: 41197197
Adjunctive nano‑curcumin reduced chronic post‑burn itch (clinically meaningful reduction in patient comfort).
- The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study
PubMed ID: 24165896
Turmeric gargle reduced mucositis severity and weight loss in head & neck patients, improving treatment tolerance/comfort.
- Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study
PubMed ID: 15673996
Pilot IBS study reported symptomatic and quality-of-life improvements with turmeric — comfort improvement for GI symptoms.
- Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial
PubMed ID: 24482090
Marked reduction in pruritus severity (uremic pruritus) indicates symptom/comfort improvement.
- Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial
PubMed ID: 27761693
OA patients experienced reduced pain and improved function, reflecting increased patient comfort.
- Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial
PubMed ID: 32926799
Knee pain and function improved, suggesting enhanced comfort in OA patients.
- Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot, Randomized Controlled Trial
PubMed ID: 32749918
Short‑term knee pain relief reported alongside small inflammatory marker change.
- Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol
PubMed ID: 33516238
Pain relief comparable to paracetamol in knee OA reflects symptomatic comfort support.
- Clinical effect of acupoint application with turmeric blistering moxibustion plaster on post-stroke hemiplegic shoulder pain
PubMed ID: 38092534
Turmeric plaster + moxibustion reduced shoulder pain and improved function post‑stroke (combined therapy).
Joint comfort (26)
- An Investigation into the Effects of a Curcumin Extract (Curcugen(®)) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study
PubMed ID: 35010916
8‑week RCT showed improved KOOS pain and objective mobility measures in knee osteoarthritis.
- A Combination of Tamarindus indica seeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity
PubMed ID: 31337958
Tamarind+turmeric extract improved 6-minute walk distance, pain scores and stair-climb performance in active adults — functional joint benefits.
- Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study
PubMed ID: 1943180
Multi-herb formula including turmeric reduced pain and disability in osteoarthritis vs placebo — clinical improvement in OA (confounded).
- Herbal formulation "turmeric extract, black pepper, and ginger" versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial
PubMed ID: 32180294
Turmeric+black pepper+ginger lowered PGE2 (inflammatory mediator) similar to naproxen in knee OA — supports joint inflammation/pain mechanism.
- Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis
PubMed ID: 24002213
Curcuma+Boswellia formulation improved OA symptoms vs low‑dose celecoxib (small trial) — clinical joint benefit signal.
- Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study
PubMed ID: 29316908
Large RCT of curcumin+boswellia in osteoarthritis produced clinically meaningful pain and performance improvements.
- A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving Joint Discomfort in Human Subjects with Osteoarthritis of Knee
PubMed ID: 29708818
Herbal formulation including Curcuma improved knee osteoarthritis pain, function and QoL vs placebo — turmeric contribution plausible but multi-ingredient.
- Efficacy of high-dissolution turmeric-sesame formulation for pain relief in adult subjects with acute musculoskeletal pain compared to acetaminophen: A randomized controlled study
PubMed ID: 32664057
Proprietary turmeric blend relieved acute musculoskeletal pain comparably to acetaminophen (analgesic effect).
- Fast pain relief in exercise-induced acute musculoskeletal pain by turmeric-boswellia formulation: A randomized placebo-controlled double-blinded multicentre study
PubMed ID: 36107505
Turmeric–boswellia oral formulation produced fast, large pain relief after exercise-related muscle/joint injury (but multi-ingredient).
- Efficacy and safety evaluation of Boswellia serrata and Curcuma longa extract combination in the management of chronic lower back pain: A randomised, double-blind, placebo-controlled clinical study
PubMed ID: 39700654
90‑patient RCT (Boswellia+Curcuma) reduced chronic low back pain and disability and lowered inflammatory markers.
- The effect of turmeric-Boswellia formulation (Rhuleave-K) in posture-related low back soreness and discomfort: A randomized double blinded placebo controlled trial
PubMed ID: 39973246
Turmeric‑Boswellia product produced rapid, large pain/disability reductions in posture‑related low back pain (combination product).
- Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study
PubMed ID: 32678677
Curcumin‑containing supplement + glucosamine reduced joint pain/function and inflammatory markers vs comparator.
- Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study
PubMed ID: 24672232
Large multicenter RCT: Curcuma domestica extract noninferior to ibuprofen for knee OA pain/function with fewer GI AEs.
- A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study
PubMed ID: 28850308
Bioavailable curcumin RCT in rheumatoid arthritis improved DAS28 and inflammatory markers and reduced symptoms.
- Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study
PubMed ID: 31351488
Well-powered RCT of bio-optimized turmeric showed marked reduction in knee pain (VAS) and reduced cartilage-degradation biomarker and analgesic use.
- Significant immunomodulatory properties of curcumin in patients with osteoarthritis; a successful clinical trial in Iran
PubMed ID: 32540725
Oral curcumin improved OA pain and lowered CRP in a small RCT.
- Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial
PubMed ID: 23242572
Randomized placebo‑controlled trial (NR-INF-02) improved knee OA pain/function (120 patients).
- Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis
PubMed ID: 19678780
Randomized trial in knee OA showed turmeric extract improved pain/function similarly to ibuprofen — strong clinical joint comfort evidence.
- Ability of curcuminoid compared to diclofenac sodium in reducing the secretion of cycloxygenase-2 enzyme by synovial fluid's monocytes of patients with osteoarthritis
PubMed ID: 22745140
Curcuminoids reduced COX‑2 secretion by synovial monocytes similar to diclofenac (biochemical/mechanistic support).
- Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial
PubMed ID: 27761693
Large RCT in knee osteoarthritis showed significant pain and function improvement versus placebo over 4 months.
- Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial
PubMed ID: 32926799
12‑week Curcuma longa extract reduced knee pain and WOMAC scores in knee osteoarthritis (double‑blind RCT).
- Effect of Turmacin supplementation on joint discomfort and functional outcome among healthy participants - A randomized placebo-controlled trial
PubMed ID: 33066856
Turmeric extract reduced exercise‑related knee pain and improved ROM and quadriceps force in healthy adults.
- Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot, Randomized Controlled Trial
PubMed ID: 32749918
One‑week formulation reduced self‑reported knee pain vs placebo and slightly lowered hsCRP.
- Efficacy and safety of combination of curcuminoid complex and diclofenac versus diclofenac in knee osteoarthritis: A randomized trial
PubMed ID: 32311961
Adding bioavailable curcumin complex to diclofenac improved KOOS pain/function and reduced rescue analgesic use.
- Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol
PubMed ID: 33516238
Large non‑inferiority RCT: bioavailable curcumin provided pain relief comparable to paracetamol for knee OA.
- Clinical effect of acupoint application with turmeric blistering moxibustion plaster on post-stroke hemiplegic shoulder pain
PubMed ID: 38092534
Turmeric-containing plaster plus moxibustion reduced post-stroke shoulder pain and improved ROM and arm function (treatment combined modalities).
Heart health (19)
- The effects of nano-curcumin supplementation on glycemic control, blood pressure, lipid profile, and insulin resistance in patients with the metabolic syndrome: A randomized, double-blind clinical trial
PubMed ID: 33851448
Nano‑micelle curcumin significantly lowered triglycerides, a cardiovascular risk factor.
- The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 33861432
Curcumin reduced pulse‑wave velocity (arterial stiffness) in metabolic syndrome patients, a cardiovascular surrogate.
- The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial
PubMed ID: 30864188
Modest reductions in triglycerides and hs-CRP in T2D patients indicate some cardiometabolic benefit.
- Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial
PubMed ID: 28735818
T2D RCT lowered total and non‑HDL cholesterol and Lp(a) and modestly raised HDL—clear atherogenic lipid improvements.
- Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial
PubMed ID: 25440375
Metabolic syndrome RCT: curcuminoids+piperine improved LDL, HDL, triglycerides and other lipid markers (favorable cardiac risk profile).
- Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting
PubMed ID: 22481014
Perioperative curcuminoids reduced in‑hospital MI incidence and lowered NT‑proBNP in a randomized trial (strong cardiovascular signal in surgical setting).
- Nutraceutical Effects on Glucose and Lipid Metabolism in Patients with Impaired Fasting Glucose: A Pilot, Double-Blind, Placebo-Controlled, Randomized Clinical Trial on a Combined Product
PubMed ID: 28537012
Multinutrient trial including turmeric improved triglycerides and HDL in impaired fasting glucose—beneficial lipid/metabolic signals though confounded.
- Hot Water Extract of Curcuma longa L. Improves Serum Inflammatory Markers and General Health in Subjects with Overweight or Prehypertension/Mild Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 31394768
Improvements in triglycerides and HDL alongside reduced inflammation suggest cardiometabolic benefit in overweight/prehypertensive subjects.
- Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial
PubMed ID: 39354480
12‑month trial demonstrated improved insulin resistance, HbA1c and modest weight loss — beneficial for cardiovascular risk.
- A minor metabolite from Curcuma longa effective against metabolic syndrome: results from a randomized, double-blind, placebo-controlled clinical study
PubMed ID: 37114318
Calebin A reduced LDL and triglycerides in metabolic syndrome, indicating lipid/cardiac risk improvement.
- Effect of turmeric on glycemic status, lipid profile, hs-CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients
PubMed ID: 30859660
Hyperlipidemic T2D trial reported reductions in some lipid fractions and weight with turmeric (short-term).
- Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD)
PubMed ID: 31017556
Improvements in HDL and lipid ratios in NAFLD study arms with turmeric (alone/with chicory) — supports lipid-related heart risk improvements.
- Effect of Curcuma longa on vascular function in native Tamilians with type 2 diabetes mellitus: A randomized, double-blind, parallel arm, placebo-controlled trial
PubMed ID: 31155769
Reduced arterial stiffness measures in T2D patients — clinically relevant vascular improvement.
- Effectiveness of the piperine-supplemented Curcuma longa L. in metabolic control of patients with type 2 diabetes: a randomised double-blind placebo-controlled clinical trial
PubMed ID: 33586583
In T2DM, curcumin reduced triglycerides (cardio risk) along with glycaemia.
- Cost-Effectiveness of Passion Fruit Albedo versus Turmeric in the Glycemic and Lipaemic Control of People with Type 2 Diabetes: Randomized Clinical Trial
PubMed ID: 33141635
In T2D patients curcumin+piperine substantially lowered triglycerides and improved HOMA‑IR, favorable for cardiovascular risk.
- Phytopreventive antihypercholesterolmic and antilipidemic perspectives of zedoary (Curcuma Zedoaria Roscoe.) herbal tea
PubMed ID: 26920896
Zedoary (Curcuma zedoaria) tea trial in hypercholesterolemic men produced modest reductions in total cholesterol and TG and a small HDL rise.
- Curcumin supplementation improves the clinical outcomes of patients with diabetes and atherosclerotic cardiovascular risk
PubMed ID: 40759997
14‑week RCT in diabetics showed improved SBP/DBP and LDL/HDL ratios with 1500 mg/day curcumin.
- Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
PubMed ID: 40573083
Improved inflammatory and metabolic measures in T2DM suggest cardiovascular‑risk benefit.
- The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
PubMed ID: 39125322
Large RCT in obese T2DM showed sustained decreases in arterial stiffness (PWV), LDL and HOMA‑IR — strong cardiometabolic benefit.
Oral health (16)
- Comparative evaluation of turmeric and chlorhexidine gluconate mouthwash in prevention of plaque formation and gingivitis: a clinical and microbiological study
PubMed ID: 22186854
Large clinical study: turmeric mouthwash lowered microbial counts and gingival inflammation comparable to chlorhexidine (but less potent on plaque).
- Evaluation of Turmeric Chip Compared with Chlorhexidine Chip as a Local Drug Delivery Agent in the Treatment of Chronic Periodontitis: A Split Mouth Randomized Controlled Clinical Trial
PubMed ID: 28731780
Split‑mouth randomized trial found turmeric chips reduced probing depth and improved attachment and plaque/gingival indices, comparable to chlorhexidine.
- Randomized Control Study of the Effects of Turmeric Mouthwash on Oral Health Status, Treatment-Induced Mucositis, and Associated Oral Dysfunctions Among Patients With Head and Neck Cancer
PubMed ID: 36066336
Turmeric mouthwash markedly reduced intolerable radiotherapy‑related oral mucositis and oral dysfunction versus active comparator.
- Antibacterial efficacy of manuka honey, ocimum sanctum, curcuma longa and 0.2% chlorhexidine mouthwash on the level of streptococcus mutans and lactobacillus acidophilus - A randomized controlled trial
PubMed ID: 36254954
Turmeric mouthrinse substantially reduced cavity‑related bacteria and improved oral hygiene measures (comparable to chlorhexidine).
- A Randomized, Placebo-Controlled Study to Evaluate the Effect of Bio-Enhanced Turmeric Formulation on Radiation-Induced Oral Mucositis
PubMed ID: 34161952
BCM‑95® markedly reduced rates of severe oral mucositis, pain and dysphagia during chemoradiotherapy (large clinical effect).
- The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study
PubMed ID: 24165896
Turmeric gargle reduced/delayed radiation mucositis and improved clinical oral outcomes vs povidone‑iodine in RCT.
- Effectiveness of an Alcohol-Free Chitosan-Curcuminoid Mouthwash Compared with Chlorhexidine Mouthwash in Denture Stomatitis Treatment: A Randomized Trial
PubMed ID: 30758216
Topical curcuminoid mouthwash (chitosan formulation) resolved denture stomatitis in most patients and reduced candida more than chlorhexidine — strong topical oral benefit.
- Effects of curcumin on crevicular levels of IL-1β and CCL28 in experimental gingivitis
PubMed ID: 26219195
Topical curcumin in experimental gingivitis blunted inflammatory marker increases comparable to CHX+metronidazole.
- A Comparative Study to Evaluate the Efficacy of Curcumin Lozenges (TurmNova(®)) and Intralesional Corticosteroids with Hyaluronidase in Management of Oral Submucous Fibrosis
PubMed ID: 34615779
Curcumin lozenges improved mouth opening and symptoms in oral submucous fibrosis vs steroid injections.
- Clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study
PubMed ID: 27720650
Oral submucous fibrosis RCT (turmeric+piperine) improved mouth opening and burning—direct oral health clinical benefit.
- Black Turmeric and Aloe Vera in the Management of Oral Submucous Fibrosis: A Prospective Clinical Study
PubMed ID: 34967575
Topical black turmeric + aloe reduced burning and improved mouth opening in oral submucous fibrosis.
- Efficacy of Improvised Topical Zinc (1%) Ora-Base on Oral Mucositis during Cancer Chemo-Radiation-A Randomized Study
PubMed ID: 32350185
Topical preparation containing curcumin associated with less severe oral mucositis vs standard care in cancer patients.
- Effects of nanomicelle curcumin capsules on prevention and treatment of oral mucosits in patients under chemotherapy with or without head and neck radiotherapy: a randomized clinical trial
PubMed ID: 34521398
Nanomicelle curcumin significantly reduced severity and pain of chemo‑induced oral mucositis vs placebo.
- Clinical and microbiological evaluation of dental plaque on topical application of olive oil, olive oil with 35% Curcuma zedoaria, and olive oil with 30% Azadirachta indica in hospitalized children: A randomized control trial
PubMed ID: 40586465
Randomized trial in hospitalized children: olive oil + Curcuma zedoaria produced largest short‑term reductions in plaque and microbial counts over 72 h.
- Effectiveness of curcumin mouthwash on radiation-induced oral mucositis among head and neck cancer patients: A triple-blind, pilot randomised controlled trial
PubMed ID: 33433509
Curcumin mouthwash delayed onset and halved short‑term risk of radiation‑induced oral mucositis in an RCT.
- Topical Curcumin and Triamcinolone Acetonide in Recurrent Minor Aphthous Ulcers: A Pilot Trial
PubMed ID: 33568610
Topical curcumin gel performed comparably to steroid paste for small mouth ulcers in a pilot study.
Liver support (13)
- Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study
PubMed ID: 35065636
Curcumin+piperine modestly improved AST and direct bilirubin in women with PMS/dysmenorrhea indicating some hepatic test changes.
- Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: A randomized controlled trial
PubMed ID: 32017253
In cirrhosis patients, 3 months of curcumin produced significant improvements in MELD/MELD‑Na and Child‑Pugh scores.
- Curcumin ameliorates health-related quality of life in patients with liver cirrhosis: A randomized, double-blind placebo-controlled trial
PubMed ID: 32147077
Curcumin improved quality‑of‑life and symptom measures in patients with cirrhosis (liver disease context).
- Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial
PubMed ID: 32147075
Curcuminoids reduced liver steatosis on ultrasound and improved liver‑related inflammatory markers in NAFLD.
- Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
PubMed ID: 40573083
12‑month RCT showed reduced liver steatosis (CAP), lower liver stiffness and improved inflammatory markers in MASLD patients.
- Curcumin Supplementation as a Preventive Strategy Against Tamoxifen-Induced Nonalcoholic Fatty Liver Disease in ER+ Breast Cancer Patients: A Triple-Blind Randomized Placebo-Controlled Trial
PubMed ID: 39948699
Curcumin reduced progression/worsening of fatty liver on ultrasound in tamoxifen‑treated breast cancer patients (6‑month RCT).
- Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD)
PubMed ID: 31017556
NAFLD trial: turmeric (with chicory) reduced BMI/waist and improved HDL and lipid ratios — relevant to liver health in NAFLD context.
- Turmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver Diseases
PubMed ID: 28443702
NAFLD RCT showed metabolic improvements in a liver disease population (glucose, insulin resistance, leptin), supportive of liver health.
- Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach
PubMed ID: 18720535
Large RCT of an herbal formulation including turmeric given with TB drugs greatly reduced hepatotoxicity and liver enzymes — strong clinical liver outcome but multi-herb confounded.
- The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study
PubMed ID: 23497020
Randomized double‑blind trial: fermented turmeric powder significantly reduced ALT and AST in subjects with elevated ALT.
- An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: A double-blind randomized controlled clinical trial
PubMed ID: 29806132
β‑thalassemia major RCT lowered non‑transferrin bound iron and modestly improved ALT/AST—direct laboratory evidence of hepatic benefit.
- A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial
PubMed ID: 30647436
Phospholipid curcumin altered bile acids and TCA-cycle and microbiota-derived metabolites in NAFLD patients — mechanistic liver/gut-liver axis effects.
- The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind, Randomized, Placebo-Controlled Trial
PubMed ID: 33861434
Phospholipid curcumin reduced hepatic steatosis grade and AST in NAFLD patients (direct liver outcome).
Blood sugar (11)
- The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
PubMed ID: 39125322
12‑month trial showed improved insulin resistance (HOMA‑IR) and related cardiometabolic parameters.
- Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial
PubMed ID: 39354480
Large 12‑month RCT in obese T2DM: improved HOMA‑β, lowered HOMA‑IR and reduced HbA1c (clinically meaningful glycemic benefits).
- Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: A randomized double-blind placebo- controlled clinical trial
PubMed ID: 30935539
Nano-curcumin significantly reduced HbA1c and fasting blood sugar in diabetic patients (randomized double-blind trial).
- Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus
PubMed ID: 29299989
Adipokine shifts (↑adiponectin, ↓leptin) and reduced TNF‑α in T2D support improved metabolic regulation relevant to glycemic control.
- Nutraceutical Effects on Glucose and Lipid Metabolism in Patients with Impaired Fasting Glucose: A Pilot, Double-Blind, Placebo-Controlled, Randomized Clinical Trial on a Combined Product
PubMed ID: 28537012
Multinutrient supplement (includes turmeric) substantially reduced fasting glucose and HOMA‑IR in impaired fasting glucose—effect likely multi‑ingredient but relevant.
- Hot Water Extract of Curcuma longa L. Improves Serum Inflammatory Markers and General Health in Subjects with Overweight or Prehypertension/Mild Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 31394768
Hot-water turmeric extract lowered fasting glucose and HbA1c across 12 weeks in overweight/prehypertensive subjects.
- A Hot Water Extract of Curcuma longa L. Improves Fasting Serum Glucose Levels in Participants with Low-Grade Inflammation: Reanalysis of Data from Two Randomized, Double-Blind, Placebo-Controlled Trials
PubMed ID: 36145139
Pooled reanalysis: hot‑water Curcuma extract lowered fasting glucose in participants with low‑grade inflammation.
- Cost-Effectiveness of Passion Fruit Albedo versus Turmeric in the Glycemic and Lipaemic Control of People with Type 2 Diabetes: Randomized Clinical Trial
PubMed ID: 33141635
Curcumin+piperine improved HbA1c and HOMA‑IR in type 2 diabetes, indicating meaningful glycemic benefits.
- Effectiveness of the piperine-supplemented Curcuma longa L. in metabolic control of patients with type 2 diabetes: a randomised double-blind placebo-controlled clinical trial
PubMed ID: 33586583
RCT in type 2 diabetes showed significant reductions in glycaemia and HbA1c with turmeric+piperine.
- Turmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver Diseases
PubMed ID: 28443702
NAFLD RCT reported significant reductions in fasting glucose, insulin and HOMA‑IR versus placebo over 12 weeks.
- Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
PubMed ID: 40573083
12‑month RCT in T2DM+MASLD showed significant reductions in HbA1c and fasting glucose versus placebo.
Antioxidant (12)
- The dose-response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise-induced muscle damage in males
PubMed ID: 40781899
Hydrolysed curcumin reduced oxidative stress (FORT) in exercise trial.
- Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting
PubMed ID: 22481014
Perioperative curcuminoids lowered oxidative stress marker (malondialdehyde) in a RCT.
- Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial
PubMed ID: 25171552
RCT in chronic pulmonary injury showed increased GSH and decreased MDA with curcuminoids+piperine.
- Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis
PubMed ID: 25618800
Well-powered RCT (curcumin+piperine) raised SOD and lowered MDA in metabolic syndrome—strong antioxidant evidence.
- Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial
PubMed ID: 25688638
Knee OA RCT reported significant increases in SOD and decreases in MDA with curcuminoids.
- The Effect of Dietary Supplementation With Curcumin on Redox Status and Nrf2 Activation in Patients With Nondiabetic or Diabetic Proteinuric Chronic Kidney Disease: A Pilot Study
PubMed ID: 26915483
Proteinuric CKD RCT demonstrated decreased lipid peroxidation and increased antioxidant capacity.
- The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor γ coactivator 1α gene expression in polycystic ovarian syndrome (PCOS) patients: A randomized placebo-controlled clinical trial
PubMed ID: 31991296
Increased antioxidant enzyme (Gpx) and mitochondrial regulator (PGC1α) in RCT of curcumin in PCOS.
- Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
PubMed ID: 40573083
12‑month RCT showed improved antioxidant markers in T2DM+MASLD—direct evidence.
- Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial
PubMed ID: 27761693
Knee OA RCT showed reductions in oxidative stress markers (ROS, MDA) alongside clinical benefit.
- Role of turmeric in oxidative modulation in end-stage renal disease patients
PubMed ID: 25131305
Randomized trial in dialysis patients showed reduced MDA and increased catalase—direct human antioxidant biomarker effects.
- Effects of a Functional Food Mixture on Patients Undergoing Hemodialysis: Preliminary Results Highlighting the Modulation of Uremic Toxins Derived From Microbiota and Antioxidant Markers
PubMed ID: 40296308
Turmeric+propolis drink increased FRAP antioxidant values in hemodialysis patients.
- An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: A double-blind randomized controlled clinical trial
PubMed ID: 29806132
β-thalassemia trial showed reductions in NTBI and improvements in liver enzymes consistent with reduced oxidative burden.
Digestive support (11)
- Beneficial Effects on Abdominal Bloating with an Innovative Food-Grade Formulation of Curcuma longa and Boswellia serrata Extracts in Subjects with Irritable Bowel Syndrome and Small Bowel Dysbiosis
PubMed ID: 35276778
Curcumin–boswellia phytosome added to low‑FODMAP diet markedly reduced bloating and abdominal pain in IBS with dysbiosis.
- Curcumin plus piperine improve body composition in patients with inflammatory bowel disease: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 39934549
12‑week curcumin+piperine in mild–moderate IBD increased lean mass and phase angle—benefits relevant to digestive disease.
- Curcumin Supplementation Improves Gastrointestinal Symptoms in Women with Severe Obesity: A Double-Blind, Randomized, Placebo-Controlled Trial-A Pilot Study
PubMed ID: 40647170
Pilot RCT in severe obesity reported significant improvements in GI symptom scores (GSRS) and specific symptoms (eructation, constipation).
- Evaluation of oral nano-curcumin formulation effectiveness in patients with mild to moderate ulcerative colitis: a randomized, placebo-controlled, double-blind clinical trial
PubMed ID: 40820062
Nano‑curcumin as add‑on improved clinical and endoscopic ulcerative colitis outcomes (direct digestive disease benefit).
- Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study
PubMed ID: 15673996
Pilot study reported reduced IBS symptoms and improved QOL with turmeric alone — supportive for digestive symptom relief (pilot design).
- Efficacy of Curcuma longa in treatment of postprandial distress syndrome: An open-label randomized-controlled trial
PubMed ID: 33510892
Functional dyspepsia trial: turmeric provided similar short-term symptom relief to simethicone (but higher recurrence rates).
- Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study
PubMed ID: 33478482
RCT in adults with digestive complaints showed modest improvement in GI symptom scores and reduced anxiety.
- Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis - a randomized, placebo-controlled, pilot study
PubMed ID: 24011514
Curcumin enema + oral 5‑ASA improved clinical/endoscopic outcomes in distal UC per‑protocol (pilot RCT).
- Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial
PubMed ID: 17101300
Adjunctive curcumin reduced relapse in ulcerative colitis — strong clinical digestive/gut disease benefit (adjunct therapy).
- [The effect of chelidonium- and turmeric root extract on upper abdominal pain due to functional disorders of the biliary system. Results from a placebo-controlled double-blind study]
PubMed ID: 10495621
Turmeric-containing extract reduced biliary-type RUQ pain faster than placebo early in treatment — symptomatic digestive benefit (combination product).
- Curcuma longa Linn versus omeprazole in treatment of functional dyspepsia: A randomized, double-blind, placebo-controlled trial
PubMed ID: 34652861
Randomized trial showed Curcuma longa improved dyspepsia pain and non‑pain symptoms comparably to omeprazole.
Immune support (9)
- Impact of curcumin supplementation on expression of inflammatory transcription factors in hemodialysis patients: A pilot randomized, double-blind, controlled study
PubMed ID: 32204978
Reduced NF‑κB mRNA and hsCRP in hemodialysis patients indicating immune/inflammatory modulation.
- Significant immunomodulatory properties of curcumin in patients with osteoarthritis; a successful clinical trial in Iran
PubMed ID: 32540725
Oral curcumin shifted circulating immune‑cell balance toward regulatory phenotype in OA patients.
- Effects of curcumin-piperine supplementation on systemic immunity in young women with premenstrual syndrome and dysmenorrhea: A randomized clinical trial
PubMed ID: 36174434
Curcumin+piperine significantly lowered serum IgE in women with PMS/dysmenorrhea, a measurable immune marker.
- The effects of curcumin supplementation on inflammatory markers in systemic lupus erythematosus patients: a randomized placebo-controlled trial
PubMed ID: 39546036
Triple-blind RCT in SLE showed reductions in anti-dsDNA and IL-6—direct immunomodulatory human data.
- The Immunomodulatory Effects of Curcumin on Forkhead Box O1 and MicroRNA-873 in Patients with Osteoarthritis
PubMed ID: 39586746
Curcumin raised expression of immune‑related genes (FOXO1, miR‑873) in knee OA patients (molecular immune effect).
- Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
PubMed ID: 40573083
Large RCT showed reductions in proinflammatory cytokines (TNF, IL‑1β, IL‑6), reflecting immune modulation.
- Evaluation of oral nano-curcumin formulation effectiveness in patients with mild to moderate ulcerative colitis: a randomized, placebo-controlled, double-blind clinical trial
PubMed ID: 40820062
Nano‑curcumin added to mesalamine improved clinical/endoscopic UC outcomes—clinical immune‑mediated disease benefit.
- A Triple-blind randomized controlled trial on the effects of turmeric versus ginger on inflammatory biomarkers in patients with COVID-19
PubMed ID: 40841392
Short RCT in mild COVID‑19 lowered CRP/ESR with turmeric—biomarker evidence of immune/inflammatory modulation.
- Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial
PubMed ID: 27761693
OA RCT lowered IL‑1β, indicating modulation of inflammatory/immune signaling in humans.
Skin health (9)
- Turmeric tonic as a treatment in scalp psoriasis: A randomized placebo-control clinical trial
PubMed ID: 29607625
Randomized topical turmeric scalp tonic improved psoriasis severity and QoL vs placebo over 9 weeks.
- Effectiveness of Ya-Samarn-Phlae in diabetic wound healing: Evidence from in vitro studies and a multicenter randomized controlled clinical trial
PubMed ID: 38373661
Traditional multi‑herbal solution containing Curcuma markedly increased diabetic ulcer healing rates vs standard care (multi‑ingredient).
- Effects of hot water extract of Curcuma longa on human epidermal keratinocytes in vitro and skin conditions in healthy participants: A randomized, double-blind, placebo-controlled trial
PubMed ID: 30809971
Hot-water turmeric extract increased facial skin moisture vs placebo in healthy participants — direct skin benefit.
- Topical Turmeric Ointment in the Treatment of Diabetic Foot Ulcers: A Randomized, Placebo-Controlled Study
PubMed ID: 36514270
Topical turmeric accelerated diabetic foot ulcer shrinkage vs placebo — clear topical wound‑healing benefit.
- Efficacy and Safety of an Oral Low-Dose Water-Dispersible Turmeric Extract Capsule on Facial Skin Health in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 40971325
60‑day RCT in healthy women showed objective improvements in facial blemishes, hydration and TEWL with low‑dose water‑dispersible turmeric.
- Efficacy of herbal anti-microbial soap in Tinea corporis: A randomized controlled study
PubMed ID: 34968662
Topical antimicrobial soap containing turmeric produced marked clinical and mycological improvement in tinea corporis.
- Curcuma aeruginosa Roxb. essential oil slows hair-growth and lightens skin in axillae; a randomised, double blinded trial
PubMed ID: 28190468
Topical Curcuma aeruginosa lotion RCT significantly lightened axillary skin and slowed hair growth—clear topical skin effects.
- Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial
PubMed ID: 24482090
Double-blind RCT in hemodialysis patients showed turmeric markedly reduced uremic pruritus severity and lowered CRP—clinically meaningful skin symptom benefit.
- Adjunctive curcumin nano-micelles reduce overall pruritus intensity in refractory post-burn pruritus: A randomized controlled trial
PubMed ID: 41197197
Nano‑curcumin adjunct reduced chronic post‑burn itch over 12 weeks (clinically meaningful skin symptom improvement).
Weight management (8)
- Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
PubMed ID: 40573083
12‑month trial reported favorable anthropometric changes in T2DM+MASLD (supportive but secondary outcome).
- Curcumin Supplementation Improves Gastrointestinal Symptoms in Women with Severe Obesity: A Double-Blind, Randomized, Placebo-Controlled Trial-A Pilot Study
PubMed ID: 40647170
13‑week pilot in severe obesity reported a small but significant BMI decrease with curcumin and GI symptom improvements.
- A minor metabolite from Curcuma longa effective against metabolic syndrome: results from a randomized, double-blind, placebo-controlled clinical study
PubMed ID: 37114318
Calebin A reduced body weight and waist size vs placebo in metabolic syndrome over 90 days.
- Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial
PubMed ID: 34774052
12‑week RCT showed prevention of modest weight gain vs placebo in overweight adults.
- Turmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver Diseases
PubMed ID: 28443702
NAFLD trial decreased leptin and improved insulin resistance—metabolic shifts supportive of weight-management biology.
- Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus
PubMed ID: 29299989
T2D trial increased adiponectin and decreased leptin and leptin:adiponectin ratio—biomarkers relevant to body weight/metabolic regulation.
- The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 33861432
Curcumin reduced body weight in metabolic syndrome trial (12 weeks).
- Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial
PubMed ID: 39354480
12‑month curcumin produced modest weight loss and improved metabolic parameters in obese T2DM patients.
Exercise recovery (7)
- Fast pain relief in exercise-induced acute musculoskeletal pain by turmeric-boswellia formulation: A randomized placebo-controlled double-blinded multicentre study
PubMed ID: 36107505
Multi‑ingredient turmeric–boswellia product produced very fast and large pain relief after exercise‑induced muscle/joint injury (strong clinical signal).
- A Combination of Tamarindus indica seeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity
PubMed ID: 31337958
Improved 6-minute walk distance, pain and stair-climb performance in active adults suggests faster functional recovery and exercise-related performance gains (tamarind+turmeric).
- Efficacy of curcuminoids for reducing postoperative pain after laparoscopic gynecologic surgery: A pilot randomized trial
PubMed ID: 31150356
Postoperative reductions in pain scores indicate curcuminoids can aid short-term recovery from surgical (physiologic) stress.
- The efficacy of curcumin in managing acute inflammation pain on the post-surgical removal of impacted third molars patients: A randomised controlled trial
PubMed ID: 29908031
Acute postoperative-analgesic effect of curcumin analogous to recovery-related pain reduction; supports short-term recovery/analgesia.
- Effect of Turmacin supplementation on joint discomfort and functional outcome among healthy participants - A randomized placebo-controlled trial
PubMed ID: 33066856
Reduced knee pain after exercise and modest improvements in knee movement/muscle function in healthy adults.
- The dose-response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise-induced muscle damage in males
PubMed ID: 40781899
Dose‑response trial found 1500 mg/day hydrolysed curcumin reduced oxidative stress, CK and soreness after intense exercise.
- A randomized, placebo-controlled, crossover clinical trial to evaluate the effect of a turmeric formulation on muscle soreness and function recovery in moderately active adults
PubMed ID: 41040018
Randomized crossover in moderately active adults showed improved muscle functional recovery and faster soreness recovery with a bioavailable turmeric formulation.
Gut health (7)
- Curcumin plus piperine improve body composition in patients with inflammatory bowel disease: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 39934549
Curcumin+piperine improved body composition and phase angle in IBD patients (supports gut‑related nutritional status).
- Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study
PubMed ID: 15673996
Pilot open study reported reduced IBS prevalence and symptom/QOL improvements with turmeric — supportive for gut symptomatic health (pilot data).
- A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial
PubMed ID: 30647436
Phospholipid curcumin produced significant changes in microbiota-derived metabolites and bile acids — strong mechanistic gut-microbiome signal.
- Beneficial Effects on Abdominal Bloating with an Innovative Food-Grade Formulation of Curcuma longa and Boswellia serrata Extracts in Subjects with Irritable Bowel Syndrome and Small Bowel Dysbiosis
PubMed ID: 35276778
Curcumin–boswellia phytosome plus low‑FODMAP markedly reduced bloating, pain and urinary indican (dysbiosis marker) in IBS patients.
- Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial
PubMed ID: 17101300
Adjunctive curcumin markedly reduced relapse and improved clinical/endoscopic indices in quiescent ulcerative colitis — strong gut-disease benefit.
- Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis - a randomized, placebo-controlled, pilot study
PubMed ID: 24011514
Curcumin enema trial for distal UC showed strong per‑protocol clinical and endoscopic improvements.
- Evaluation of oral nano-curcumin formulation effectiveness in patients with mild to moderate ulcerative colitis: a randomized, placebo-controlled, double-blind clinical trial
PubMed ID: 40820062
Nano‑curcumin improved clinical and endoscopic measures in ulcerative colitis—direct gut‑health benefit.
Healthy aging (6)
- Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
PubMed ID: 40573083
12‑month metabolic/liver trial showed sustained improvements in inflammation and liver health that relate to healthier aging processes.
- Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study
PubMed ID: 32512782
Cognitive and fatigue improvements in older adults support aspects of healthy aging.
- The Efficacy of the Novel Bioavailable Curcumin (Cureit) in the Management of Sarcopenia in Healthy Elderly Subjects: A Randomized, Placebo-Controlled, Double-Blind Clinical Study
PubMed ID: 33290142
Small gains in grip strength and reduced activity‑related fatigue in older adults suggest functional aging benefits.
- Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial
PubMed ID: 39354480
12-month improvements in insulin sensitivity, β‑cell function and modest weight loss support metabolic aspects of healthy aging.
- The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
PubMed ID: 39125322
Long-term reductions in arterial stiffness, lipids and inflammation are relevant to healthy aging and vascular health.
- Dietary associations with reduced epigenetic age: a secondary data analysis of the methylation diet and lifestyle study
PubMed ID: 40266024
Secondary analysis found higher 'methyl‑adaptogen' intake (including turmeric) associated with modest epigenetic age reversal.
Blood circulation (6)
- Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting
PubMed ID: 22481014
Perioperative curcuminoids lowered NT‑proBNP and MI incidence, indicating improved perioperative cardiac/circulatory outcomes.
- Effect of Curcuma longa on vascular function in native Tamilians with type 2 diabetes mellitus: A randomized, double-blind, parallel arm, placebo-controlled trial
PubMed ID: 31155769
Three-month Curcuma supplementation reduced multiple arterial-stiffness measures in type 2 diabetes — strong vascular/circulatory effect.
- Curcumin supplementation improves the clinical outcomes of patients with diabetes and atherosclerotic cardiovascular risk
PubMed ID: 40759997
Improved systolic/diastolic BP and favorable LDL/HDL changes in diabetics indicate circulation/cardiometabolic benefit.
- Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial
PubMed ID: 40573083
Metabolic and inflammatory improvements in T2DM+MASLD support vascular risk reduction (indirect).
- The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
PubMed ID: 39125322
Significant reductions in pulse wave velocity (arterial stiffness) over 12 months indicate improved vascular/circulatory health.
- The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 33861432
Curcumin improved arterial stiffness (PWV) in metabolic syndrome — direct circulation support evidence.
Respiratory comfort (5)
- Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers
PubMed ID: 36419388
Polyherbal (including turmeric) shortened COVID‑19 illness and symptoms (respiratory comfort), but turmeric not isolated.
- A randomized, controlled, blinded, parallel group, clinical trial to study the role of Ayurcov (AyurCoro3), one day regimen as an adjuvant therapy for COVID-19 disease management, at dedicated Covid Hospital (DCH) in India
PubMed ID: 35341943
Ayurcov (multi-ingredient including turmeric) shortened cough and breathlessness duration in mild–moderate COVID‑19 (attribution limited).
- Efficacy of Nanocurcumin as an Add-On Treatment for Patients Hospitalized with COVID-19: A Double-Blind, Randomized Clinical Trial
PubMed ID: 37547100
Nanocurcumin in hospitalized COVID‑19 reduced cough, myalgia, oxygen needs and improved SpO2 — meaningful respiratory benefit.
- Short-term Curcuminoid Supplementation for Chronic Pulmonary Complications due to Sulfur Mustard Intoxication: Positive Results of a Randomized Double-blind Placebo-controlled Trial
PubMed ID: 25268878
4‑week RCT in patients with chronic sulfur-mustard lung injury improved FEV1/FVC and reduced IL-6 and hs-CRP—direct respiratory benefit.
- Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial
PubMed ID: 25171552
RCT in patients with chronic pulmonary complications from sulfur mustard showed improved respiratory QoL and antioxidant markers.
Mood balance (4)
- Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study
PubMed ID: 25046624
Small RCT found modest but significant antidepressant effects of curcumin over 4–8 weeks.
- Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study
PubMed ID: 27723543
Randomized double‑blind trial found curcumin (±saffron) reduced depression and anxiety scores vs placebo over 12 weeks.
- Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study
PubMed ID: 33478482
Trial reported reduced anxiety scores alongside GI symptom improvement.
- Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial
PubMed ID: 34774052
Improved SF‑36 mental health and POMS anger‑hostility scores in RCT.
Mental clarity (2)
- Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study
PubMed ID: 27723543
Depression/anxiety RCT mainly measured mood but improvements in anxiety/depression can plausibly support perceived mental clarity.
- Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study
PubMed ID: 32512782
Bioavailable curcumin improved working memory, spatial learning and reduced fatigue in older adults in a double‑blind RCT.
Similar by evidence
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Products with Turmeric
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Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.