Lycopene
18 benefits mapped to clinical evidence across supplements.
Dose per serving from products
2,036 products in our catalogue print how much Lycopene a serving holds.
Most common: 500 mcg to 1 mg, 17% of 2,036 products.
| Dose per serving | Products |
|---|---|
| 100 mcg or less | 54 |
| 100 mcg to 250 mcg | 107 |
| 250 mcg to 500 mcg | 342 |
| 500 mcg to 1 mg | 352 |
| 1 mg to 2.5 mg | 225 |
| 2.5 mg to 5 mg | 244 |
| 5 mg to 10 mg | 311 |
| 10 mg to 25 mg | 212 |
| 25 mg to 50 mg | 143 |
| over 50 mg | 46 |
Dose per serving from research
101 study groups in 63 studies say how much Lycopene participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 10 mg to 25 mg, 38% of 101 study groups.
| Daily dose | Study groups |
|---|---|
| 2.5 mg or less | 2 |
| 2.5 mg to 5 mg | 13 |
| 5 mg to 10 mg | 19 |
| 10 mg to 25 mg | 38 |
| 25 mg to 50 mg | 27 |
| over 50 mg | 2 |
Commonly used together
23 of 98 study groups took Lycopene with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Beta-Carotene | 8 |
| Lutein | 4 |
| Soy Isoflavones | 4 |
Benefit Evidence
Better vasodilation +63%
Lower BP -12 mmHg
More lycopene, less inflammation
Lower cytokines, markers
Skin/gum inflammation ↓
Acute postmeal inflammation ↓
Better vasodilation +63%
Lower BP -12 mmHg
More lycopene, less inflammation
Research sources
Heart health (19)
- Effects of tomato juice consumption on plasma and lipoprotein carotenoid concentrations and the susceptibility of low density lipoprotein to oxidative modification
PubMed ID: 11575576
Tomato juice raised lipoprotein lycopene and reduced LDL propagation rate (potential anti-atherogenic effect).
- Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial
PubMed ID: 24911964
RCT in CVD patients: 7 mg lycopene improved endothelial function (surrogate of cardiac vascular health).
- The consumption of processed tomato products enhances plasma lycopene concentrations in association with a reduced lipoprotein sensitivity to oxidative damage
PubMed ID: 12612144
Processed tomato products improved lipoprotein resistance to oxidation, a mechanism relevant to cardiovascular risk.
- Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men
PubMed ID: 21194693
15 mg/day lycopene improved endothelial function (RH-PAT), a key cardiovascular biomarker.
- A randomised controlled trial of increasing fruit and vegetable intake and how this influences the carotenoid concentration and activities of PON-1 and LCAT in HDL from subjects with type 2 diabetes
PubMed ID: 24423117
Increased lycopene in HDL3 and raised HDL antioxidant enzymes—mechanistic support for cardiovascular protection.
- The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients
PubMed ID: 19052855
Treated hypertensives had large systolic/diastolic BP reductions with tomato extract (lycopene source), a strong cardiovascular risk benefit.
- Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes
PubMed ID: 10840987
Tomato juice increased LDL resistance to oxidation in type 2 diabetics—an anti-atherogenic surrogate.
- Effects of two lipid-lowering, carotenoid-controlled diets on the oxidative modification of low-density lipoproteins in free-living humans
PubMed ID: 12780345
MUFA/lycopene‑high diet improved LDL oxidation resistance and HDL/triglycerides versus high-carb diet, relevant to heart health.
- Consumption of whole grain and legume powder reduces insulin demand, lipid peroxidation, and plasma homocysteine concentrations in patients with coronary artery disease: randomized controlled clinical trial
PubMed ID: 11742886
Dietary intervention in CAD patients improved metabolic and oxidative markers with concurrent lycopene rise, supporting heart-health relevance.
- LycoRed as an alternative to hormone replacement therapy in lowering serum lipids and oxidative stress markers: a randomized controlled clinical trial
PubMed ID: 16764620
LycoRed produced favorable lipid and oxidative-stress changes in postmenopausal women similar to HRT, supporting cardiovascular risk reduction.
- Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals
PubMed ID: 22819555
Improved HDL function and reduced HDL-associated inflammation—mechanistically relevant to heart health.
- Effects of lutein and lycopene on carotid intima-media thickness in Chinese subjects with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial
PubMed ID: 24047757
Combination carotenoid trial (includes lycopene) reduced carotid intima-media thickness, a CVD surrogate.
- [Effect of lycopene on blood lipoproteids in women with type 2 diabetes mellitus in postmenopause]
PubMed ID: 15049152
Randomized trial in diabetic postmenopausal women showed substantial reductions in total and LDL cholesterol, relevant to heart risk.
- Effect of 12-Week Daily Intake of the High-Lycopene Tomato (Solanum Lycopersicum), A Variety Named "PR-7", on Lipid Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study
PubMed ID: 31130668
High-lycopene tomato reduced LDL-C modestly, lowering cardiovascular risk.
- Effect of Tomato Nutrient Complex on Blood Pressure: A Double Blind, Randomized Dose⁻Response Study
PubMed ID: 31035474
Tomato nutrient complex lowered systolic BP in hypertensives, relevant to cardiac risk.
- Effect of a novel functional tomato sauce (OsteoCol) from vine-ripened tomatoes on serum lipids in individuals with common hypercholesterolemia: tomato sauce and hypercholesterolemia
PubMed ID: 33407609
Vine-ripened tomato sauce lowered LDL-C in hypercholesterolemic adults.
- Association between tomato consumption and blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial
PubMed ID: 38001046
Observational tomato intake associated with lower incident hypertension and small BP changes.
- Improvement of vascular endothelial function by intake of lycopene-rich tomato juice in healthy adults: a randomized, placebo-controlled, double-blind, parallel-group comparative study
PubMed ID: 40936452
Improved endothelial function (FMD) after lycopene-rich tomato juice — direct vascular benefit.
- Tomato Puree Enrichment in a High-Fat Meal Reduces Postprandial Plasma and Adipose Tissue Inflammation Biomarkers in Healthy Male Adults: A Crossover Randomized Controlled Trial
PubMed ID: 40351054
Tomato puree acutely reduced postprandial systemic and adipose inflammation relevant to cardiometabolic health.
Antioxidant (25)
- The effectiveness of tomato extract on superoxide dismutase (SOD) and severity degree of patients with melasma
PubMed ID: 35707866
Oral tomato extract increased serum SOD (antioxidant enzyme) in an RCT adjunct to topical therapy.
- A randomised controlled trial of increasing fruit and vegetable intake and how this influences the carotenoid concentration and activities of PON-1 and LCAT in HDL from subjects with type 2 diabetes
PubMed ID: 24423117
Raised HDL‑associated antioxidant enzymes (PON‑1, LCAT) and HDL lycopene in T2D patients.
- Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, β-carotene, and Lactobacillus johnsonii: results from a randomized, placebo-controlled, double-blinded study
PubMed ID: 24283388
Supplement containing lycopene reduced clinical UVA responses and inflammatory markers—consistent with antioxidant/photoprotective effects.
- Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men
PubMed ID: 21194693
15 mg/day lycopene increased SOD activity and reduced lymphocyte DNA damage (antioxidant effect).
- Plasma and dietary carotenoids are associated with reduced oxidative stress in women previously treated for breast cancer
PubMed ID: 17932348
Duplicate entry to emphasize strong observational link to lower oxidative DNA damage.
- Four week supplementation with mixed fruit and vegetable juice concentrates increased protective serum antioxidants and folate and decreased plasma homocysteine in Japanese subjects
PubMed ID: 17704021
Large RCT: serum lycopene rose markedly and oxidative stress markers fell.
- Immunity and antioxidant capacity in humans is enhanced by consumption of a dried, encapsulated fruit and vegetable juice concentrate
PubMed ID: 16988134
Fruit/vegetable concentrate raised plasma lycopene, antioxidant capacity (ORAC) and reduced DNA damage.
- Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women
PubMed ID: 16400064
Lycopene-containing supplementation lowered lymphocyte DNA damage in older women, consistent with antioxidant/protective effects.
- The consumption of processed tomato products enhances plasma lycopene concentrations in association with a reduced lipoprotein sensitivity to oxidative damage
PubMed ID: 12612144
Clear increases in plasma lycopene and reproducible improvement in ex vivo lipoprotein resistance to oxidation.
- Dietary supplementation with a natural carotenoid mixture decreases oxidative stress
PubMed ID: 12947433
Carotenoid mix including lycopene reduced LDL oxidative susceptibility and urinary 8‑OHdG (DNA oxidation marker).
- Paraoxonase 1 Q192R (PON1-192) polymorphism is associated with reduced lipid peroxidation in R-allele-carrier but not in QQ homozygous elderly subjects on a tomato-rich diet
PubMed ID: 12474066
Tomato juice increased carotenoids and reduced LDL oxidation in genotype-defined subgroup; supports antioxidant action in some individuals.
- Effects of tomato juice consumption on plasma and lipoprotein carotenoid concentrations and the susceptibility of low density lipoprotein to oxidative modification
PubMed ID: 11575576
Dose-dependent increases in lipoprotein lycopene and reduced LDL propagation rate at high dose indicate antioxidant activity in lipoproteins.
- Improvement of Executive Function after Short-Term Administration of an Antioxidants Mix Containing Bacopa, Lycopene, Astaxanthin and Vitamin B12: The BLAtwelve Study
PubMed ID: 33375429
Multicomponent supplement containing lycopene produced large reductions in oxidative-stress biomarkers (8-isoprostane, MDA) in older adults.
- Tomato Phytonutrients Balance UV Response: Results from a Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 30836363
Carotenoid‑rich tomato extract attenuated UVB‑induced inflammatory/oxidative cytokine responses and raised plasma carotenoids.
- Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study
PubMed ID: 27662341
Oral lycopene‑rich tomato supplement suppressed UV‑induced stress‑gene expression in skin (mechanistic antioxidant effect).
- Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women
PubMed ID: 20552330
Randomized trial showed increased total antioxidant capacity and reduced oxidative markers after 4 months of lycopene.
- Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes
PubMed ID: 10840987
Tomato juice raised plasma lycopene ~3-fold and increased LDL oxidation lag time by ~42% in diabetics.
- Effects of two lipid-lowering, carotenoid-controlled diets on the oxidative modification of low-density lipoproteins in free-living humans
PubMed ID: 12780345
Carotenoid-controlled (lycopene-high) diet increased LDL oxidation lag time vs high-carb diet.
- LycoRed as an alternative to hormone replacement therapy in lowering serum lipids and oxidative stress markers: a randomized controlled clinical trial
PubMed ID: 16764620
LycoRed lowered malondialdehyde and increased glutathione, indicating antioxidant effects.
- Tomato juice consumption improves blood antioxidative biomarkers in overweight and obese females
PubMed ID: 25466953
RCT in humans showing increased TAC and antioxidant enzymes and reduced MDA.
- The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 31468596
Improved seminal total antioxidant capacity alongside sperm improvements in an RCT.
- Efficacy of antioxidants therapy on progression of periodontal disease - A randomized control trial
PubMed ID: 34810387
Lycopene+green tea raised salivary antioxidant levels in gingivitis patients (human RCT but combined agents).
- A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress
PubMed ID: 18689558
Well-powered dose–response trial showing dose-dependent plasma rises and reduced lymphocyte DNA damage/urinary 8-OHdG at 30 mg/day.
- Efficacy of lycopene as a locally delivered gel in the treatment of chronic periodontitis: smokers vs nonsmokers
PubMed ID: 22536592
Topical lycopene gel reduced local oxidative DNA damage markers in periodontal sites.
- A comparison of plasma and prostate lycopene in response to typical servings of tomato soup, sauce or juice in men before prostatectomy
PubMed ID: 26202168
Dietary tomato markedly raised plasma and prostate lycopene (tissue antioxidant availability).
Urinary comfort (15)
- A combination of tomato and soy products for men with recurring prostate cancer and rising prostate specific antigen
PubMed ID: 18444145
Tomato/soy diet increased serum lycopene and reduced VEGF with some PSA decreases in prostate cancer patients.
- Lycopene and soy isoflavones in the treatment of prostate cancer
PubMed ID: 17927495
Phase II study showed PSA stabilization in most patients receiving lycopene for rising PSA.
- Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA
PubMed ID: 27406859
Short tomato intervention lowered PSA in an intermediate‑risk prostate‑cancer subgroup and PSA reductions associated with plasma lycopene rises.
- Serenoa repens associated with selenium and lycopene extract and bromelain and methylsulfonylmethane extract are able to improve the efficacy of levofloxacin in chronic bacterial prostatitis patients
PubMed ID: 27711089
Supplement containing lycopene added to levofloxacin decreased symptomatic/microbiological recurrence of chronic bacterial prostatitis—benefit in urinary/prostatic tract infections (multi-ingredient).
- Plasma carotenoids and tocopherols in relation to prostate-specific antigen (PSA) levels among men with biochemical recurrence of prostate cancer
PubMed ID: 26165176
Higher plasma lycopene during a diet intervention was associated with lower subsequent PSA in men with recurrent prostate cancer (associational evidence).
- Lycopene intake and prostate cancer risk in men at high cardiovascular risk: a prospective cohort study
PubMed ID: 41214650
Prospective analysis: higher cumulative lycopene intake strongly associated with lower prostate cancer incidence.
- Serenoa repens + selenium + lycopene vs tadalafil 5 mg for the treatment of lower urinary tract symptoms secondary to benign prostatic obstruction: a Phase IV, non-inferiority, open-label, clinical study (SPRITE study)
PubMed ID: 29569389
Serenoa repens + selenium + lycopene combo improved LUTS and urinary flow (Qmax) vs tadalafil; lycopene attribution limited by combination.
- A comparison of plasma and prostate lycopene in response to typical servings of tomato soup, sauce or juice in men before prostatectomy
PubMed ID: 26202168
Short dietary interventions (~3 weeks) produced very large increases in prostate tissue lycopene (strong tissue‑exposure evidence).
- Serenoa repens, lycopene and selenium versus tamsulosin for the treatment of LUTS/BPH. An Italian multicenter double-blinded randomized study between single or combination therapy (PROCOMB trial)
PubMed ID: 25154739
Phytocomplex including lycopene + tamsulosin produced greater IPSS/Qmax improvements than monotherapies in LUTS/BPH patients.
- Effects of Serenoa repens, selenium and lycopene (Profluss®) on chronic inflammation associated with benign prostatic hyperplasia: results of "FLOG" (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study
PubMed ID: 23683667
Combination phytotherapy (including lycopene) reduced prostatic inflammation and immune cell markers in men with BPH/PIN.
- A phase II randomised double-blind placebo-controlled clinical trial investigating the efficacy and safety of ProstateEZE Max: a herbal medicine preparation for the management of symptoms of benign prostatic hypertrophy
PubMed ID: 23642948
Multi‑herb capsule containing lycopene improved urinary symptoms (IPSS, frequency) in men with BPH over 3 months.
- Antioxidant effects of lycopene in African American men with prostate cancer or benign prostate hyperplasia: a randomized, controlled trial
PubMed ID: 21430075
Lycopene raised plasma and prostate lycopene in 21‑day trial; prostate 8‑oxo‑dG fell (−35%) though not statistically significant.
- Differential effects of lycopene consumed in tomato paste and lycopene in the form of a purified extract on target genes of cancer prostatic cells
PubMed ID: 20392890
Human serum after tomato/lycopene intake altered cancer-related gene expression in prostate cancer cells ex vivo—suggests biological activity relevant to prostate health.
- Lycopene inhibits disease progression in patients with benign prostate hyperplasia
PubMed ID: 18156403
Six-month supplementation reduced PSA and appeared to prevent prostate enlargement in men with BPH (pilot RCT).
- A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer
PubMed ID: 12930422
Randomized trial in metastatic prostate cancer showing improved PSA responses, bone-scan responses and fewer deaths with lycopene added to orchidectomy.
Blood circulation (12)
- Effects of lutein and lycopene on carotid intima-media thickness in Chinese subjects with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial
PubMed ID: 24047757
Reduced carotid intima-media thickness (combo carotenoids) suggests improved vascular structure.
- LycoRed as an alternative to hormone replacement therapy in lowering serum lipids and oxidative stress markers: a randomized controlled clinical trial
PubMed ID: 16764620
Lipid and oxidative-stress improvements are consistent with better circulatory risk profile.
- The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients
PubMed ID: 19052855
Marked BP reductions with tomato extract would improve circulation and hemodynamics.
- A randomised controlled trial of increasing fruit and vegetable intake and how this influences the carotenoid concentration and activities of PON-1 and LCAT in HDL from subjects with type 2 diabetes
PubMed ID: 24423117
Improved HDL lycopene and HDL enzyme activities imply better lipoprotein function and circulation support.
- Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men
PubMed ID: 21194693
15 mg/day lycopene improved endothelial function (RH-PAT), indicating improved microvascular circulation.
- Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial
PubMed ID: 24911964
Randomized placebo-controlled lycopene (7 mg/day) in CVD patients produced large improvements in endothelium-dependent vasodilatation—direct evidence for circulation support.
- Tomato Puree Enrichment in a High-Fat Meal Reduces Postprandial Plasma and Adipose Tissue Inflammation Biomarkers in Healthy Male Adults: A Crossover Randomized Controlled Trial
PubMed ID: 40351054
Reduced postprandial systemic inflammation and adipose inflammation could favor circulation.
- Improvement of vascular endothelial function by intake of lycopene-rich tomato juice in healthy adults: a randomized, placebo-controlled, double-blind, parallel-group comparative study
PubMed ID: 40936452
Improved FMD indicates better endothelial-dependent circulation after lycopene-rich tomato juice.
- Association between tomato consumption and blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial
PubMed ID: 38001046
Observational tomato consumption linked to lower incident hypertension risk, relevant to circulation.
- Effect of Tomato Nutrient Complex on Blood Pressure: A Double Blind, Randomized Dose⁻Response Study
PubMed ID: 31035474
Tomato nutrient complex lowered SBP and DBP, improving circulatory load.
- [Effect of lycopene on blood lipoproteids in women with type 2 diabetes mellitus in postmenopause]
PubMed ID: 15049152
Lowered LDL and total cholesterol in diabetics likely benefits circulation and vascular risk.
- Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals
PubMed ID: 22819555
Improved HDL function and enzyme activities likely support vascular health and circulation.
Healthy aging (7)
- A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress
PubMed ID: 18689558
Reduction in DNA oxidative damage and urinary 8-OHdG suggests protection of cellular macromolecules relevant to aging.
- LycoRed as an alternative to hormone replacement therapy in lowering serum lipids and oxidative stress markers: a randomized controlled clinical trial
PubMed ID: 16764620
LycoRed improved lipids and oxidative-stress markers in postmenopausal women, markers tied to aging-related risk.
- Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled trial
PubMed ID: 40876538
Higher baseline blood carotenoids (including lycopene) associated with better preserved cognition over 3 years in APOE ε4 carriers.
- Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women
PubMed ID: 16400064
Lycopene-containing supplements reduced DNA damage in older women, a marker linked to cellular aging.
- Fruits, vegetables, and antioxidants and risk of gastric cancer among male smokers
PubMed ID: 16172214
Higher dietary lycopene associated with lower noncardia gastric cancer risk in male smokers, consistent with longer‑term health/aging benefit.
- Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women
PubMed ID: 20552330
Increased antioxidant capacity and reduced bone resorption marker in postmenopausal women—biological markers related to aging.
- Lycopene intake and prostate cancer risk in men at high cardiovascular risk: a prospective cohort study
PubMed ID: 41214650
Higher cumulative lycopene intake associated with substantially lower prostate cancer incidence in older men (long-term health relevance).
Cholesterol (14)
- Effect of 12-Week Daily Intake of the High-Lycopene Tomato (Solanum Lycopersicum), A Variety Named "PR-7", on Lipid Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study
PubMed ID: 31130668
Double-blind RCT: semidried high-lycopene tomato produced a significant LDL-C reduction vs placebo.
- Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals
PubMed ID: 22819555
Strong RCT evidence that lycopene intake improved HDL-related enzyme activities and reduced HDL inflammation.
- LycoRed as an alternative to hormone replacement therapy in lowering serum lipids and oxidative stress markers: a randomized controlled clinical trial
PubMed ID: 16764620
LycoRed produced large favorable changes in total cholesterol (−24%), LDL (−15%) and increased HDL (+26%) in randomized trial.
- Effects of low-fat stanol ester enriched margarines on concentrations of serum carotenoids in subjects with elevated serum cholesterol concentrations
PubMed ID: 10602355
Stanol‑enriched margarines lowered several carotenoids and related lipids; demonstrates interaction of lipid‑lowering foods with carotenoid status and clear cholesterol lowering.
- Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects
PubMed ID: 10334658
Low‑dose plant sterol spreads lowered total and LDL cholesterol modestly while leaving lycopene unchanged — direct evidence for cholesterol lowering (not lycopene efficacy).
- Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects
PubMed ID: 9630383
Sterol‑enriched margarines produced consistent total/LDL cholesterol reductions; lycopene tended to fall — study supports a cholesterol‑lowering approach but lycopene was secondary.
- Effects of two lipid-lowering, carotenoid-controlled diets on the oxidative modification of low-density lipoproteins in free-living humans
PubMed ID: 12780345
Dietary change with high-lycopene increased HDL and lowered triglycerides and improved LDL oxidation.
- A randomised controlled trial of increasing fruit and vegetable intake and how this influences the carotenoid concentration and activities of PON-1 and LCAT in HDL from subjects with type 2 diabetes
PubMed ID: 24423117
Increased lycopene in HDL3 and elevated HDL enzymes (PON‑1, LCAT) suggesting better HDL function.
- Serum lipid and antioxidant responses in hypercholesterolemic men and women receiving plant sterol esters vary by apolipoprotein E genotype
PubMed ID: 19056656
Plant sterol RCT lowered LDL and concomitantly reduced circulating carotenoids (including lycopene) in a genotype-dependent manner.
- Reduced-calorie orange juice beverage with plant sterols lowers C-reactive protein concentrations and improves the lipid profile in human volunteers
PubMed ID: 17023701
Plant‑sterol orange beverage reduced LDL and CRP; lycopene unchanged but lipid improvements are clear.
- Long-term compliance and changes in plasma lipids, plant sterols and carotenoids in children and parents with FH consuming plant sterol ester-enriched spread
PubMed ID: 15199384
Long‑term plant‑sterol spread lowered LDL cholesterol in familial hypercholesterolemia patients; associated with modest lycopene decrease in parents.
- Spreads enriched with plant sterols, either esterified 4,4-dimethylsterols or free 4-desmethylsterols, and plasma total- and LDL-cholesterol concentrations
PubMed ID: 10655976
Plant‑sterol spread lowered total and LDL cholesterol and produced a measurable (~9.5%) reduction in lipid‑standardized lycopene — shows interplay between cholesterol management and lycopene status.
- Effect of a novel functional tomato sauce (OsteoCol) from vine-ripened tomatoes on serum lipids in individuals with common hypercholesterolemia: tomato sauce and hypercholesterolemia
PubMed ID: 33407609
Crossover trial: vine-ripened tomato sauce lowered LDL-C comparably to sterol-enriched yogurt in adherent participants.
- [Effect of lycopene on blood lipoproteids in women with type 2 diabetes mellitus in postmenopause]
PubMed ID: 15049152
Randomized, placebo-controlled study showed ~12% reduction in total cholesterol and ~16% reduction in LDL after 12 weeks.
Cell health (12)
- Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women
PubMed ID: 20552330
Reduced oxidative damage markers and raised antioxidant capacity—cellular protection implications.
- Tomato Puree Enrichment in a High-Fat Meal Reduces Postprandial Plasma and Adipose Tissue Inflammation Biomarkers in Healthy Male Adults: A Crossover Randomized Controlled Trial
PubMed ID: 40351054
Marked reductions in inflammatory gene expression in adipose tissue and systemic inflammation after tomato puree.
- Differential effects of lycopene consumed in tomato paste and lycopene in the form of a purified extract on target genes of cancer prostatic cells
PubMed ID: 20392890
Serum after tomato/lycopene intake altered expression of apoptosis and cell-cycle genes in prostate cancer cells ex vivo.
- A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress
PubMed ID: 18689558
Dose-dependent reduction in lymphocyte DNA damage and urinary 8-OHdG indicates protection of cellular DNA.
- Dietary supplementation with a natural carotenoid mixture decreases oxidative stress
PubMed ID: 12947433
Reduced urinary 8‑OHdG (DNA oxidative damage) and improved LDL stability with carotenoid mix suggests cellular protection.
- Plasma and buccal mucosal cell response to short-term supplementation with all trans-beta-carotene and lycopene in human volunteers
PubMed ID: 14612979
Rapid increases in plasma and buccal mucosal lycopene demonstrate tissue uptake and potential cellular access.
- Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women
PubMed ID: 16400064
Supplementation lowered DNA strand breaks in lymphocytes of older women, a direct marker of cellular protection.
- Immunity and antioxidant capacity in humans is enhanced by consumption of a dried, encapsulated fruit and vegetable juice concentrate
PubMed ID: 16988134
Reduced lymphocyte DNA damage and improved antioxidant markers indicate cellular protection.
- Plasma and dietary carotenoids are associated with reduced oxidative stress in women previously treated for breast cancer
PubMed ID: 17932348
Higher carotenoids associated with lower oxidative DNA damage—direct marker of cellular protection.
- A randomised controlled trial of increasing fruit and vegetable intake and how this influences the carotenoid concentration and activities of PON-1 and LCAT in HDL from subjects with type 2 diabetes
PubMed ID: 24423117
Enhanced HDL antioxidant enzymes (PON‑1, LCAT) and lycopene enrichment in HDL3 support protection of cellular lipids.
- Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study
PubMed ID: 27662341
Suppression of UV stress genes in skin indicates cellular stress resistance induced by tomato nutrients.
- Tomato lycopene extract supplementation decreases insulin-like growth factor-I levels in colon cancer patients
PubMed ID: 17554202
Twofold plasma lycopene and ~25% IGF-I decrease in colon cancer patients with potential effects on cell proliferation pathways.
Inflammation (10)
- Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals
PubMed ID: 22819555
Decrease in serum and HDL-associated SAA indicates reduced HDL-associated inflammation.
- Tomato Phytonutrients Balance UV Response: Results from a Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 30836363
Tomato extract attenuated UVB‑induced IL‑6 and TNF‑α—direct anti‑inflammatory evidence in skin.
- Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study
PubMed ID: 27662341
Tomato nutrient suppressed UV‑inducible stress/inflammatory gene expression (HO1, ICAM1, MMP1).
- Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, β-carotene, and Lactobacillus johnsonii: results from a randomized, placebo-controlled, double-blinded study
PubMed ID: 24283388
Supplement containing lycopene reduced ICAM-1 mRNA expression and clinical UVA responses (reduced inflammatory markers).
- Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants
PubMed ID: 21760585
Carotenoid supplementation in preterm infants lowered CRP and improved retinal function—clear anti-inflammatory signal.
- Tomato juice consumption reduces systemic inflammation in overweight and obese females
PubMed ID: 23069270
Tomato juice reduced IL‑8, TNF‑α and IL‑6 in overweight/obese subgroups — clear anti‑inflammatory signals.
- The adjunctive use of systemic antioxidant therapy (lycopene) in nonsurgical treatment of chronic periodontitis: a short-term evaluation
PubMed ID: 23479592
Systemic lycopene adjunct reduced salivary IL‑1β and improved periodontal inflammatory markers.
- Tomato Puree Enrichment in a High-Fat Meal Reduces Postprandial Plasma and Adipose Tissue Inflammation Biomarkers in Healthy Male Adults: A Crossover Randomized Controlled Trial
PubMed ID: 40351054
Acute high-fat meal study: tomato puree markedly reduced plasma inflammatory markers and adipose inflammatory gene expression.
- Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept
PubMed ID: 18324527
Tomato products reduced airway neutrophils and neutrophil elastase in adults with asthma after low-antioxidant diet.
- Effects of Serenoa repens, selenium and lycopene (Profluss®) on chronic inflammation associated with benign prostatic hyperplasia: results of "FLOG" (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study
PubMed ID: 23683667
Combination phytotherapy including lycopene reduced prostatic inflammation and immune infiltrates in men with BPH/PIN.
Oral health (10)
- A comparative study to evaluate the efficacy of lycopene and curcumin in oral submucous fibrosis patients: A randomized clinical trial
PubMed ID: 29900913
In oral submucous fibrosis patients, 3 months of oral lycopene improved mouth opening (~0.35 cm) and eliminated burning pain in a randomized trial.
- Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: A randomized controlled trial
PubMed ID: 30059188
Large RCT (n=90) showed 8 mg lycopene twice daily for 6 months significantly improved mouth opening and multiple oral function measures vs placebo.
- Evaluation of Therapeutic Efficacy of Different Treatment Modalities in Oral Submucous Fibrosis: A Comparative Study
PubMed ID: 31204333
Oral lycopene improved symptoms and mouth opening in oral submucous fibrosis, though less than injectable therapy.
- Natural products for the management of xerostomia: a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 27550537
Topical lycopene‑enriched olive oil spray improved xerostomia symptoms and oral quality‑of‑life in elderly patients.
- The adjunctive use of systemic antioxidant therapy (lycopene) in nonsurgical treatment of chronic periodontitis: a short-term evaluation
PubMed ID: 23479592
Systemic lycopene with scaling improved several clinical gum‑health measures and reduced salivary IL‑1β versus placebo.
- Efficacy of lycopene as a locally delivered gel in the treatment of chronic periodontitis: smokers vs nonsmokers
PubMed ID: 22536592
Topical lycopene gel improved periodontal probing depth, attachment levels and reduced local oxidative damage (randomized split‑mouth trial).
- Lycopene in the management of oral lichen planus: a placebo-controlled study
PubMed ID: 22406705
Oral lycopene pills substantially reduced pain and improved symptoms in oral lichen planus (RCT).
- Efficacy of lycopene in the management of oral submucous fibrosis
PubMed ID: 17234537
Randomized placebo-controlled study showed improved mouth opening in oral submucous fibrosis with lycopene.
- Efficacy of oral lycopene in the treatment of oral leukoplakia
PubMed ID: 15063387
Randomized placebo-controlled trial showed marked clinical and histological improvement in oral leukoplakia with oral lycopene.
- Efficacy of antioxidants therapy on progression of periodontal disease - A randomized control trial
PubMed ID: 34810387
Lycopene + green tea supplementation increased salivary antioxidants and improved gingivitis indices in an RCT.
Blood pressure (4)
- Effect of Tomato Nutrient Complex on Blood Pressure: A Double Blind, Randomized Dose⁻Response Study
PubMed ID: 31035474
Tomato nutrient complex (lycopene-standardized) significantly reduced systolic BP in untreated hypertensives.
- Association between tomato consumption and blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial
PubMed ID: 38001046
Prospective cohort: higher tomato consumption associated with lower incident hypertension and small DBP reduction.
- The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients
PubMed ID: 19052855
Double-blind crossover in treated hypertensives showed ~12 mmHg systolic and ~5 mmHg diastolic reductions with tomato extract (lycopene source).
- Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas
PubMed ID: 12767566
Large RCT in pregnancy showed lower mean maternal diastolic BP with lycopene.
Metabolism (7)
- Tomato Puree Enrichment in a High-Fat Meal Reduces Postprandial Plasma and Adipose Tissue Inflammation Biomarkers in Healthy Male Adults: A Crossover Randomized Controlled Trial
PubMed ID: 40351054
Tomato puree blunted postprandial inflammation and adipose inflammatory gene expression — relevant to metabolic regulation.
- A comparison of the effect of free access to reduced fat products or their full fat equivalents on food intake, body weight, blood lipids and fat-soluble antioxidants levels and haemostasis variables
PubMed ID: 9683389
Reduced‑fat diet trial lowered weight gain risk and improved blood lipids (metabolic outcomes); lycopene itself did not change, but the study is relevant to metabolic balance interventions.
- Effects of two lipid-lowering, carotenoid-controlled diets on the oxidative modification of low-density lipoproteins in free-living humans
PubMed ID: 12780345
Dietary pattern with higher lycopene improved triglycerides and HDL versus a high-carb diet, indicating metabolic improvements.
- Consumption of whole grain and legume powder reduces insulin demand, lipid peroxidation, and plasma homocysteine concentrations in patients with coronary artery disease: randomized controlled clinical trial
PubMed ID: 11742886
Replacing refined rice lowered glucose/insulin and oxidative stress while increasing carotenoids (including lycopene) in CAD patients.
- [Effect of lycopene on blood lipoproteids in women with type 2 diabetes mellitus in postmenopause]
PubMed ID: 15049152
In type 2 diabetic postmenopausal women, lycopene lowered total and LDL cholesterol—beneficial metabolic effect.
- Effect of 12-Week Daily Intake of the High-Lycopene Tomato (Solanum Lycopersicum), A Variety Named "PR-7", on Lipid Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study
PubMed ID: 31130668
High-lycopene tomato produced a modest but significant LDL reduction.
- Effect of a novel functional tomato sauce (OsteoCol) from vine-ripened tomatoes on serum lipids in individuals with common hypercholesterolemia: tomato sauce and hypercholesterolemia
PubMed ID: 33407609
Tomato sauce lowered LDL-C in hypercholesterolemic adults, indicating metabolic benefit.
Skin appearance (6)
- Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study
PubMed ID: 27662341
Oral tomato nutrient suppressed UV‑induced skin stress genes—strong mechanistic photoprotective effect relevant to skin appearance.
- Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, β-carotene, and Lactobacillus johnsonii: results from a randomized, placebo-controlled, double-blinded study
PubMed ID: 24283388
12-week supplement containing lycopene reduced UVA-induced skin lesion scores and inflammatory markers in PLE patients.
- Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema
PubMed ID: 12514275
Mixed carotenoid supplementation (including lycopene) raised skin/blood carotenoids and reduced UV‑induced erythema — direct skin appearance benefit.
- The effectiveness of tomato extract on superoxide dismutase (SOD) and severity degree of patients with melasma
PubMed ID: 35707866
RCT showed oral tomato extract plus topical therapy reduced melasma severity (direct clinical skin‑appearance benefit).
- Wrinkle reduction in post-menopausal women consuming a novel oral supplement: a double-blind placebo-controlled randomized study
PubMed ID: 23927381
Oral multi-nutrient supplement including lycopene reduced facial wrinkle depth ~10% and increased dermal collagen in postmenopausal women.
- Tomato Phytonutrients Balance UV Response: Results from a Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 30836363
Tomato extract reduced UVB‑induced erythema and inflammatory cytokines—clinical photoprotection tied to skin appearance.
Skin health (4)
- Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study
PubMed ID: 27662341
Duplicate entry (same strong evidence as above).
- Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, β-carotene, and Lactobacillus johnsonii: results from a randomized, placebo-controlled, double-blinded study
PubMed ID: 24283388
12-week oral supplement containing lycopene significantly reduced UVA-induced skin lesions in PLE patients.
- Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema
PubMed ID: 12514275
Carotenoid supplementation (including lycopene) reduced UV‑induced erythema and raised skin carotenoids — direct evidence of photoprotection.
- Tomato Phytonutrients Balance UV Response: Results from a Double-Blind, Randomized, Placebo-Controlled Study
PubMed ID: 30836363
Tomato extract reduced UVB‑induced erythema and inflammatory cytokines in a randomized trial—clinical photoprotection demonstrated.
Fertility (3)
- A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy males
PubMed ID: 31591650
RCT: lactolycopene raised plasma lycopene and improved several sperm motility/morphology measures.
- The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 31468596
RCT in men with oligozoospermia showing significant improvements in sperm count, concentration and seminal TAC.
- Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas
PubMed ID: 12767566
Large RCT in pregnancy showing reduced pre-eclampsia/IUGR and higher fetal weight—strong reproductive outcome.
Brain health (2)
- Improvement of Executive Function after Short-Term Administration of an Antioxidants Mix Containing Bacopa, Lycopene, Astaxanthin and Vitamin B12: The BLAtwelve Study
PubMed ID: 33375429
Randomized trial of a supplement including lycopene (with bacopa, astaxanthin, B12) improved executive function in older adults; lycopene may contribute but multiple actives present.
- Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled trial
PubMed ID: 40876538
Higher baseline blood carotenoids (including lycopene) associated with better preserved cognition over 3 years in APOE ε4 carriers.
Immune support (2)
- The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses
PubMed ID: 35956264
Increased plasma carotenoids via F&V intake associated with improved innate immune responses and fewer multiple asthma/URTI events.
- Immunity and antioxidant capacity in humans is enhanced by consumption of a dried, encapsulated fruit and vegetable juice concentrate
PubMed ID: 16988134
Supplement increased a T‑cell subset (gamma‑delta T cells) and reduced DNA damage, indicating immune modulation.
Eye health (1)
- Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants
PubMed ID: 21760585
Supplementation in preterm infants improved rod photoreceptor sensitivity and raised retinally relevant carotenoids.
Bone health (1)
- Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women
PubMed ID: 20552330
Four months of lycopene reduced N-telopeptide (NTx), a validated bone-resorption marker, in postmenopausal women.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Lycopene
Search all3147 products whose verified label declares Lycopene — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.