Anthocyanins
19 benefits mapped to clinical evidence across supplements.
Dose per serving from products
65 products in our catalogue print how much Anthocyanins a serving holds.
Most common: 25 mg to 50 mg, 37% of 65 products.
| Dose per serving | Products |
|---|---|
| 2.5 mg or less | 2 |
| 2.5 mg to 5 mg | 7 |
| 5 mg to 10 mg | 6 |
| 10 mg to 25 mg | 11 |
| 25 mg to 50 mg | 24 |
| 50 mg to 100 mg | 6 |
| 100 mg to 250 mg | 8 |
| over 250 mg | 1 |
Dose per serving from research
124 study groups in 89 studies say how much Anthocyanins participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 29% of 124 study groups.
| Daily dose | Study groups |
|---|---|
| 10 mg or less | 6 |
| 10 mg to 25 mg | 4 |
| 25 mg to 50 mg | 11 |
| 50 mg to 100 mg | 18 |
| 100 mg to 250 mg | 34 |
| 250 mg to 500 mg | 36 |
| 500 mg to 1 g | 7 |
| 1 g to 2.5 g | 4 |
| over 2.5 g | 4 |
Commonly used together
43 of 129 study groups took Anthocyanins with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Black Currant | 15 |
| Fiber | 3 |
Benefit Evidence
Dry eye symptoms/tear stability +11.35
Glaucoma/night vision/IOP
Retinal protection/visual recovery
Inflammation↓, IFN-γ
Oxidative stress↓, 8-isoprostane
Immune cells↑, IL-10
Fat oxidation +25-29%
Body fat/weight loss
Insulin/lipid improvements
Dry eye symptoms/tear stability +11.35
Glaucoma/night vision/IOP
Retinal protection/visual recovery
Research sources
Heart health (32)
- Diabetes Therapeutics of Prebiotic Soluble Dietary Fibre and Antioxidant Anthocyanin Supplement in Patients with Type 2 Diabetes: Randomised Placebo-Controlled Clinical Trial
PubMed ID: 40218856
60‑day anthocyanin + prebiotic reduced LDL‑C (−13.4%) along with glycemic improvements in T2D patients.
- Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial
PubMed ID: 36972800
Improved endothelial function and lowered ambulatory SBP in older adults — cardio‑protective signals.
- Improvement on blood pressure and skin using roselle drink: A clinical trial
PubMed ID: 35758855
Roselle drink lowered blood pressure and raised antioxidant capacity in a 6‑month trial.
- Anthocyanin supplementation at different doses improves cholesterol efflux capacity in subjects with dyslipidemia-a randomized controlled trial
PubMed ID: 32317748
Large RCT showed dose-dependent increases in cholesterol efflux capacity and modest HDL-C/ApoA-I rises — favorable for heart health.
- Dose-dependent reductions in plasma ceramides after anthocyanin supplementation are associated with improvements in plasma lipids and cholesterol efflux capacity in dyslipidemia: A randomized controlled trial
PubMed ID: 33131908
Dose-dependent reductions in plasma ceramides and improvements in lipids/HDL function in dyslipidemic subjects — cardiometabolic relevance.
- Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial
PubMed ID: 31136659
6‑month blueberry RCT in metabolic syndrome improved endothelial function, reduced arterial stiffness and increased HDL‑related markers—strong cardiac risk marker improvement.
- A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults
PubMed ID: 29882843
Wild blueberry extract modestly lowered systolic blood pressure in older adults; heart‑relevant.
- Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction: an open-label randomized clinical trial
PubMed ID: 30803503
Bilberry after MI improved walking distance and lowered oxidized LDL—clinically relevant post‑MI benefit.
- Blueberry anthocyanin intake attenuates the postprandial cardiometabolic effect of an energy-dense food challenge: Results from a double blind, randomized controlled trial in metabolic syndrome participants
PubMed ID: 34883305
Blueberry attenuated postprandial metabolic stress and HDL decline—relevant to cardiac risk in MetS patients.
- Anthocyanin Rich-Black Soybean Testa Improved Visceral Fat and Plasma Lipid Profiles in Overweight/Obese Korean Adults: A Randomized Controlled Trial
PubMed ID: 27809637
Black soybean testa improved abdominal fat and several lipids in overweight adults — supportive of cardiometabolic risk reduction.
- Aronia berry polyphenol consumption reduces plasma total and low-density lipoprotein cholesterol in former smokers without lowering biomarkers of inflammation and oxidative stress: a randomized controlled trial
PubMed ID: 28215316
Aronia lowered total and LDL cholesterol in former smokers — lipid improvements supportive of heart health.
- Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril
PubMed ID: 26600645
Hibiscus lowered systolic BP and aldosterone — favorable for heart health via afterload/RAAS modulation.
- Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia
PubMed ID: 26482148
Systolic BP reduction in older adults over 12 weeks—helpful for cardiac risk profile in that population.
- Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients
PubMed ID: 25833778
24‑week RCT in T2D improved lipids (TG down, HDL up), fasting glucose and HOMA‑IR—meaningful heart disease risk factor improvements.
- Plant food anthocyanins inhibit platelet granule secretion in hypercholesterolaemia: Involving the signalling pathway of PI3K-Akt
PubMed ID: 25077916
Large trial lowered multiple platelet activation markers—antithrombotic mechanism relevant to heart protection.
- Anthocyanin supplementation improves HDL-associated paraoxonase 1 activity and enhances cholesterol efflux capacity in subjects with hypercholesterolemia
PubMed ID: 24285687
24‑week RCT in hypercholesterolemic subjects improved HDL/LDL and increased cholesterol efflux capacity—strong cardiometabolic benefit.
- Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study
PubMed ID: 32349893
HDL increases and higher TAC provide supportive but indirect heart‑protective signals.
- Dietary intake of anthocyanins improves arterial stiffness, but not endothelial function, in volunteers with excess weight: A randomized clinical trial
PubMed ID: 36206152
Reduced arterial stiffness (PWV) with açaí during weight‑loss diet.
- Effect of consumption of anthocyanin-rich products on NMR lipoprotein subclasses and biomarkers in hypercholesterolemic subjects: a randomized controlled trial (the AppleCOR study)
PubMed ID: 39950742
Consistent reductions in LDL‑C, ApoB and LDL particle measures are cardioprotective biomarkers.
- Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial
PubMed ID: 15330492
Hibiscus lowered systolic BP (clinically meaningful), supporting cardiovascular/heart benefit.
- Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease
PubMed ID: 16169367
Pomegranate juice reduced stress-induced myocardial ischemia in CAD patients—direct cardiac ischemia improvement.
- Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial
PubMed ID: 17315307
Hibiscus extract lowered BP substantially and inhibited ACE—cardioprotective mechanisms relevant to heart support.
- Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects
PubMed ID: 19640950
Large RCT in dyslipidemic adults raised HDL, lowered LDL and increased cholesterol efflux—cardio-relevant lipid improvements.
- Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals
PubMed ID: 21926181
Improved endothelial-dependent vasodilation (FMD) and NO–cGMP signaling in hypercholesterolemic adults.
- [Therapeutic use Hibiscus sabadariffa extract in the treatment of hypercholesterolemia. A randomized clinical trial]
PubMed ID: 22185846
Hibiscus (anthocyanin-containing) extract lowered triglycerides in hypercholesterolemic subjects.
- Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial
PubMed ID: 22906565
24-week anthocyanins reduced inflammatory markers and improved LDL/HDL in high-cholesterol adults.
- Improved lipid profile in hyperlipidemic patients taking Vaccinium arctostaphylos fruit hydroalcoholic extract: a randomized double-blind placebo-controlled clinical trial
PubMed ID: 23686894
Vaccinium arctostaphylos extract produced substantial LDL/TG reductions and raised HDL in hyperlipidemic patients.
- The effect of barberry (Berberis integerrima) on lipid profile and systemic inflammation in subjects with cardiovascular risk factors: a randomized controlled trial
PubMed ID: 35255880
Barberry reduced TG, total/LDL and sd‑LDL and lowered CRP in at‑risk adults.
- Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial
PubMed ID: 34392146
12‑week anthocyanins reduced platelet activation/aggregation and oxidative stress—mechanistically supportive of cardiac/vascular protection.
- Role of Purified Anthocyanins in Improving Cardiometabolic Risk Factors in Chinese Men and Women with Prediabetes or Early Untreated Diabetes-A Randomized Controlled Trial
PubMed ID: 28994705
12-week purified anthocyanins modestly lowered LDL and improved apolipoproteins in prediabetes/early diabetes — cardiometabolic benefit.
- Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidemia
PubMed ID: 32179241
Dose-dependent lowering of inflammatory and oxidative biomarkers in dyslipidemic subjects supports cardiac risk reduction.
- Synergistic Effects of Microencapsulated Polyphenols and Concurrent Training on Metabolic Health and Fitness in Overweight/Obese Adults with Prediabetes
PubMed ID: 41228432
Improvements in lipids, inflammation and fitness in prediabetes are supportive of cardiac health.
Blood circulation (25)
- Plant food anthocyanins inhibit platelet granule secretion in hypercholesterolaemia: Involving the signalling pathway of PI3K-Akt
PubMed ID: 25077916
Large RCT in hypercholesterolemia reduced platelet activation markers—antithrombotic/circulatory benefit.
- Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial
PubMed ID: 36972800
RCT showed improved FMD and −3.6 mmHg 24‑h systolic BP with blueberry anthocyanins.
- Improvement on blood pressure and skin using roselle drink: A clinical trial
PubMed ID: 35758855
Roselle drink lowered blood pressure over 6 months.
- Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial
PubMed ID: 34392146
12‑week anthocyanin RCT reduced platelet activation/aggregation and oxidative stress—reduces thrombotic risk and supports vascular health.
- Blueberry anthocyanin intake attenuates the postprandial cardiometabolic effect of an energy-dense food challenge: Results from a double blind, randomized controlled trial in metabolic syndrome participants
PubMed ID: 34883305
Blueberry added to a meal attenuated postprandial HDL decline and improved metabolic responses—beneficial for postprandial vascular stress.
- Anthocyanin supplementation at different doses improves cholesterol efflux capacity in subjects with dyslipidemia-a randomized controlled trial
PubMed ID: 32317748
Large trial showed improved HDL function and modest HDL increases — relevant to vascular health.
- Dose-dependent reductions in plasma ceramides after anthocyanin supplementation are associated with improvements in plasma lipids and cholesterol efflux capacity in dyslipidemia: A randomized controlled trial
PubMed ID: 33131908
Improvements in ceramides and lipid metrics in dyslipidemic subjects imply vascular benefit.
- Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial
PubMed ID: 31136659
Large 6‑month RCT: 1 cup/day blueberries improved endothelial function (FMD), reduced arterial stiffness and improved HDL metrics—strong circulation evidence.
- A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults
PubMed ID: 29882843
Wild blueberry extract modestly lowered systolic blood pressure in older adults.
- Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction: an open-label randomized clinical trial
PubMed ID: 30803503
Bilberry in post‑MI patients improved 6‑minute walk distance and reduced oxidized LDL, consistent with improved cardiovascular function.
- Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril
PubMed ID: 26600645
Hibiscus (anthocyanin-containing) reduced systolic BP and aldosterone — strong circulatory/vascular effect.
- Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia
PubMed ID: 26482148
12‑week cherry juice lowered systolic BP in older adults with dementia—circulatory benefit in a clinical population.
- Anthocyanin supplementation improves HDL-associated paraoxonase 1 activity and enhances cholesterol efflux capacity in subjects with hypercholesterolemia
PubMed ID: 24285687
24‑week supplement in hypercholesterolemia improved HDL/LDL and cholesterol efflux—beneficial for circulation.
- Improved lipid profile in hyperlipidemic patients taking Vaccinium arctostaphylos fruit hydroalcoholic extract: a randomized double-blind placebo-controlled clinical trial
PubMed ID: 23686894
Whortleberry extract markedly improved lipid profile in hyperlipidemic patients—supports circulatory risk reduction.
- Two-year randomized, placebo-controlled study of black currant anthocyanins on visual field in glaucoma
PubMed ID: 22377796
Black currant anthocyanins increased ocular blood flow — circulation effect in ocular vasculature.
- Effects of cranberry juice consumption on vascular function in patients with coronary artery disease
PubMed ID: 21411615
Cranberry juice reduced central arterial stiffness (cfPWV) in CAD patients.
- Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals
PubMed ID: 21926181
Large RCT showed robust improvement in FMD and cGMP — clear endothelial function benefit.
- Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects
PubMed ID: 19640950
Improved HDL/LDL and cholesterol efflux can benefit vascular health indirectly.
- Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial
PubMed ID: 17315307
Standardized Hibiscus extract produced clinically relevant SBP/DBP reductions and ACE inhibition in hypertensive patients.
- Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease
PubMed ID: 16169367
Pomegranate juice modestly reduced stress-induced myocardial ischemia (improved inducible ischemia), relevant to coronary circulation.
- Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial
PubMed ID: 15330492
Hibiscus infusion (anthocyanin-containing) lowered systolic BP comparably to captopril in mild–moderate hypertension—strong circulation effect.
- [Comparative study of the effectiveness of continuous or intermittent courses of a phlebotonic drug on venous disorders disclosed or aggravated by oral, estrogen-progesterone contraceptives]
PubMed ID: 1528969
Ribes nigrum extract markedly reduced pain/edema from chronic venous insufficiency—direct clinical benefit for venous circulation.
- Effect of consumption of anthocyanin-rich products on NMR lipoprotein subclasses and biomarkers in hypercholesterolemic subjects: a randomized controlled trial (the AppleCOR study)
PubMed ID: 39950742
Reductions in LDL‑C, ApoB and LDL‑P indicate improved atherogenic lipid profile relevant to circulation.
- Dietary intake of anthocyanins improves arterial stiffness, but not endothelial function, in volunteers with excess weight: A randomized clinical trial
PubMed ID: 36206152
Açaí intake reduced arterial stiffness (PWV) in overweight subjects.
- Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study
PubMed ID: 32349893
Açaí/juçara increased HDL and antioxidant enzymes, favorable for vascular health though indirect.
Cholesterol (22)
- Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals
PubMed ID: 21926181
Large RCT: anthocyanins increased HDL, lowered LDL and improved endothelial function—clear cholesterol/fraction improvements.
- Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress
PubMed ID: 16046716
Lyophilized grape powder lowered triglycerides and LDL and reduced apolipoproteins—meaningful improvements in lipid profile.
- Effect of consumption of anthocyanin-rich products on NMR lipoprotein subclasses and biomarkers in hypercholesterolemic subjects: a randomized controlled trial (the AppleCOR study)
PubMed ID: 39950742
6‑week RCT in hypercholesterolemia showed significant LDL‑C, ApoB and LDL‑P reductions.
- Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study
PubMed ID: 32349893
Açaí and juçara juices increased HDL by +7.7% and +11.4% and raised TAC/antioxidant enzymes in a 4‑week randomized crossover.
- Synergistic Effects of Microencapsulated Polyphenols and Concurrent Training on Metabolic Health and Fitness in Overweight/Obese Adults with Prediabetes
PubMed ID: 41228432
Improvements in triglycerides and atherogenic index when combined with training support lipid balance.
- Diabetes Therapeutics of Prebiotic Soluble Dietary Fibre and Antioxidant Anthocyanin Supplement in Patients with Type 2 Diabetes: Randomised Placebo-Controlled Clinical Trial
PubMed ID: 40218856
Anthocyanin + prebiotic supplement reduced LDL‑C by ~13.4% in a 60‑day randomized trial in T2D patients.
- The effect of barberry (Berberis integerrima) on lipid profile and systemic inflammation in subjects with cardiovascular risk factors: a randomized controlled trial
PubMed ID: 35255880
8‑week barberry RCT reduced TG, total and LDL‑C and small‑dense LDL.
- Blueberry anthocyanin intake attenuates the postprandial cardiometabolic effect of an energy-dense food challenge: Results from a double blind, randomized controlled trial in metabolic syndrome participants
PubMed ID: 34883305
Blueberry added to a meal attenuated postprandial HDL decline and preserved HDL/ApoA1 measures in MetS patients.
- Skin toxicity following radiotherapy in patients with breast carcinoma: is anthocyanin supplementation beneficial?
PubMed ID: 33051045
Anthocyanin supplement prevented radiotherapy‑related rises in total and HDL cholesterol and triglycerides (secondary outcome) in a large trial.
- Anthocyanin supplementation at different doses improves cholesterol efflux capacity in subjects with dyslipidemia-a randomized controlled trial
PubMed ID: 32317748
Large RCT showed dose-dependent increases in cholesterol efflux capacity (CEC) and modest rises in HDL-C/ApoA‑I — strong lipid benefits.
- Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction: an open-label randomized clinical trial
PubMed ID: 30803503
Bilberry reduced oxidized LDL (~20%), indicating improved LDL oxidative status though total LDL effects not primary.
- Role of Purified Anthocyanins in Improving Cardiometabolic Risk Factors in Chinese Men and Women with Prediabetes or Early Untreated Diabetes-A Randomized Controlled Trial
PubMed ID: 28994705
Purified anthocyanins modestly lowered LDL-c and improved apolipoproteins in prediabetes/early diabetes.
- Anthocyanin Rich-Black Soybean Testa Improved Visceral Fat and Plasma Lipid Profiles in Overweight/Obese Korean Adults: A Randomized Controlled Trial
PubMed ID: 27809637
Black soybean testa (anthocyanin-rich) reduced abdominal fat and improved triglycerides and LDL/non-HDL measures in overweight adults.
- Aronia berry polyphenol consumption reduces plasma total and low-density lipoprotein cholesterol in former smokers without lowering biomarkers of inflammation and oxidative stress: a randomized controlled trial
PubMed ID: 28215316
Aronia extract (12 weeks) significantly lowered total and LDL cholesterol in former smokers.
- Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients
PubMed ID: 25833778
T2D 24‑week RCT raised HDL ~19% and lowered triglycerides and LDL—robust lipid improvements.
- Anthocyanin supplementation improves HDL-associated paraoxonase 1 activity and enhances cholesterol efflux capacity in subjects with hypercholesterolemia
PubMed ID: 24285687
24‑week RCT in hypercholesterolemic people increased HDL, lowered LDL and greatly improved HDL efflux capacity—strong cholesterol benefit.
- Improved lipid profile in hyperlipidemic patients taking Vaccinium arctostaphylos fruit hydroalcoholic extract: a randomized double-blind placebo-controlled clinical trial
PubMed ID: 23686894
Vaccinium arctostaphylos extract produced large clinically relevant reductions in total cholesterol/LDL/TG and raised HDL over 2 months.
- Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial
PubMed ID: 22906565
24-week anthocyanin trial produced −10.4% LDL and +14.0% HDL with reduced inflammatory markers.
- [Therapeutic use Hibiscus sabadariffa extract in the treatment of hypercholesterolemia. A randomized clinical trial]
PubMed ID: 22185846
Hibiscus extract standardized to anthocyanins lowered triglycerides in hypercholesterolemic individuals.
- Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects
PubMed ID: 19640950
12-week RCT in dyslipidemic adults produced +13.7% HDL, −13.6% LDL and increased cholesterol efflux.
- Dose-dependent reductions in plasma ceramides after anthocyanin supplementation are associated with improvements in plasma lipids and cholesterol efflux capacity in dyslipidemia: A randomized controlled trial
PubMed ID: 33131908
Dose-dependent reductions in specific plasma ceramides and improvements correlated with non-HDL-C and HDL function in dyslipidemia.
- Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial
PubMed ID: 31136659
One‑cup/day blueberries increased HDL‑related markers (apoA‑I, HDL particle number) and raised HDL in statin nonusers in a large RCT.
Antioxidant (24)
- [Administration of natural anthocyanins derived from chokeberry (aronia melanocarpa) extract in the treatment of oligospermia in males with enhanced autoantibodies to oxidized low density lipoproteins (oLAB). The impact on fructose levels]
PubMed ID: 11883256
Chokeberry decreased oxidized‑LDL antibodies markedly in oligospermic men—evidence of systemic antioxidant effect on this marker.
- [Administration of natural anthocyanins derived from chokeberry retardation of idiopathic and preeclamptic origin. Influence on metabolism of plasma oxidized lipoproteins: the role of autoantibodies to oxidized low density lipoproteins]
PubMed ID: 11082935
Chokeberry anthocyanins produced substantial reductions in oxidized‑LDL antibodies, a strong oxidative stress marker.
- Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study
PubMed ID: 32349893
Açaí/juçara increased total antioxidant capacity and antioxidant enzyme activities (SOD/CAT/GPx) in 4‑week RCT.
- Açaí (Euterpe oleracea Mart.) beverage consumption improves biomarkers for inflammation but not glucose- or lipid-metabolism in individuals with metabolic syndrome in a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 29850709
Açaí lowered urinary 8‑isoprostane, indicating reduced systemic lipid peroxidation.
- A Randomized Clinical Trial Evaluating the Efficacy of an Anthocyanin-Maqui Berry Extract (Delphinol®) on Oxidative Stress Biomarkers
PubMed ID: 26400431
Maqui decreased Ox-LDL and F2-isoprostanes — direct reductions in oxidative-stress biomarkers.
- Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients
PubMed ID: 25833778
T2D RCT increased antioxidant capacity and adiponectin alongside metabolic benefits—robust antioxidant signal in patients.
- Anthocyanins from fruit juices improve the antioxidant status of healthy young female volunteers without affecting anti-inflammatory parameters: results from the randomised, double-blind, placebo-controlled, cross-over ANTHONIA (ANTHOcyanins in Nutrition Investigation Alliance) study
PubMed ID: 25089359
Human RCT raised endogenous antioxidant enzymes (SOD, catalase), TEAC and lowered MDA—strong antioxidant evidence.
- Acute reduction of serum 8-iso-PGF2-alpha and advanced oxidation protein products in vivo by a polyphenol-rich beverage; a pilot clinical study with phytochemical and in vitro antioxidant characterization
PubMed ID: 21676230
Polyphenol beverage produced large acute reductions in oxidative stress markers and increased antioxidant capacity.
- An Anthocyanin- and Anti-Ageing Amino Acids-Enriched Pigmented Rice Innovation Promotes Healthy Ageing Through the Modulation of Telomere, Oxidative Stress and Inflammation Reduction: A Randomized Clinical Trial
PubMed ID: 41303396
Decrease in urinary 8‑OHdG indicates reduced oxidative DNA damage.
- Antiaging, Brightening, and Antioxidant Efficacy of Fermented Bilberry Extract (Vaccinium myrtillus): A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39064646
Fermented bilberry increased skin antioxidant capacity (FRAP) alongside skin improvements.
- Improvement on blood pressure and skin using roselle drink: A clinical trial
PubMed ID: 35758855
Roselle increased TEAC, glutathione, SOD and other antioxidant markers over 6 months.
- Anthocyanin complex niosome gel accelerates oral wound healing: In vitro and clinical studies
PubMed ID: 34214683
Topical anthocyanin niosome gel improved healing and symptom scores with antioxidant/anti‑inflammatory mechanisms implied.
- Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial
PubMed ID: 34392146
Dose‑response RCT showing reductions in urinary 8‑iso‑PGF2α and serum MDA — strong human evidence of antioxidant effect.
- Combination of plant phenolics and isoquinolinium alkaloids protects gingival fibroblast and improves post-extraction healing after lower third molar extraction
PubMed ID: 34617520
Topical anthocyanin paste reduced ROS in cells and sped oral wound healing—local antioxidant/anti‑inflammatory activity shown.
- Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidemia
PubMed ID: 32179241
12-week anthocyanin supplementation produced large, dose-dependent reductions in oxidative-stress biomarkers (8-iso-PGF2α, 8-OHdG, MDA).
- A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial
PubMed ID: 32278858
Short-term graded supplementation lowered oxidative stress markers in a dose-related manner.
- Consumption of An Anthocyanin-Rich Antioxidant Juice Accelerates Recovery of Running Economy and Indirect Markers of Exercise-Induced Muscle Damage Following Downhill Running
PubMed ID: 31547503
Attenuation of muscle damage markers and faster recovery likely mediated partly via antioxidant effects.
- Antioxidative activity and health benefits of anthocyanin-rich fruit juice in healthy volunteers
PubMed ID: 31088176
Anthocyanin-rich juice increased SOD activity over 8 weeks (antioxidant enzyme increase).
- Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women
PubMed ID: 31284490
Juçara/xanthophyll intervention produced modest FRAP and total polyphenol increases in plasma.
- Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction: an open-label randomized clinical trial
PubMed ID: 30803503
Bilberry reduced oxidized LDL and raised anthocyanin metabolites—direct antioxidant/oxidative‑damage outcome.
- Sour Cherries but Not Apples Added to the Regular Diet Decrease Resting and fMLP-Stimulated Chemiluminescence of Fasting Whole Blood in Healthy Subjects
PubMed ID: 28985142
Sour cherry lowered phagocyte oxidant generation, reducing a primary source of oxidative species.
- Association between different dietary polyphenol subclasses and the improvement in cardiometabolic risk factors: evidence from a randomized controlled clinical trial
PubMed ID: 29151225
Higher anthocyanidin intake associated with reduced urinary isoprostanes in a polyphenol-rich dietary study.
- Pigmented potato consumption alters oxidative stress and inflammatory damage in men
PubMed ID: 21106930
Purple potatoes lowered DNA oxidation (8-OHdG) vs white potato—antioxidant action from anthocyanin-rich food.
- Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress
PubMed ID: 16046716
Grape powder reduced urinary F2-isoprostanes (whole-body oxidative stress marker) and improved lipid profile.
Cell health (21)
- Consumption of An Anthocyanin-Rich Antioxidant Juice Accelerates Recovery of Running Economy and Indirect Markers of Exercise-Induced Muscle Damage Following Downhill Running
PubMed ID: 31547503
Post-exercise reduction in muscle-damage markers and faster recovery suggests reduced cellular damage from exercise.
- Antioxidative activity and health benefits of anthocyanin-rich fruit juice in healthy volunteers
PubMed ID: 31088176
8-week anthocyanin-rich juice increased SOD activity and modestly reduced body fat; antioxidant enzyme upregulation suggests cellular protection.
- Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women
PubMed ID: 31284490
Juçara/xanthophyll supplementation modestly raised plasma antioxidant measures (FRAP/total polyphenols) in obese postmenopausal women.
- Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction: an open-label randomized clinical trial
PubMed ID: 30803503
Post‑MI bilberry reduced oxidized LDL (marker of oxidative damage) and raised anthocyanin metabolites—strong cellular oxidative‑damage signal.
- Sour Cherries but Not Apples Added to the Regular Diet Decrease Resting and fMLP-Stimulated Chemiluminescence of Fasting Whole Blood in Healthy Subjects
PubMed ID: 28985142
Sour cherry reduced phagocyte oxidant generation—direct reduction of cellular oxidative assault.
- Association between different dietary polyphenol subclasses and the improvement in cardiometabolic risk factors: evidence from a randomized controlled clinical trial
PubMed ID: 29151225
Dietary anthocyanidins associated with reduced urinary isoprostanes (oxidative-stress marker) in a polyphenol diet study.
- A Randomized Clinical Trial Evaluating the Efficacy of an Anthocyanin-Maqui Berry Extract (Delphinol®) on Oxidative Stress Biomarkers
PubMed ID: 26400431
Maqui decreased Ox-LDL and F2-isoprostanes — direct markers of reduced oxidative damage to lipids/cells.
- Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients
PubMed ID: 25833778
24‑week RCT in T2D increased antioxidant capacity and adiponectin while improving metabolic markers—cell protection implications.
- Anthocyanins from fruit juices improve the antioxidant status of healthy young female volunteers without affecting anti-inflammatory parameters: results from the randomised, double-blind, placebo-controlled, cross-over ANTHONIA (ANTHOcyanins in Nutrition Investigation Alliance) study
PubMed ID: 25089359
Randomized crossover: raised plasma SOD/catalase and TEAC and lowered MDA—robust antioxidant/cellular protection markers.
- Pigmented potato consumption alters oxidative stress and inflammatory damage in men
PubMed ID: 21106930
Purple potato intake lowered 8-OHdG (DNA oxidation) relative to white potato.
- A CONSORT-compliant, randomized, double-blind, placebo-controlled pilot trial of purified anthocyanin in patients with nonalcoholic fatty liver disease
PubMed ID: 25997043
In NAFLD, anthocyanins reduced ALT, CK‑18 apoptosis marker and MPO—reduced liver cell injury and oxidative/inflammatory stress.
- Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study
PubMed ID: 32349893
Açaí/juçara increased TAC and antioxidant enzyme activities (SOD/CAT/GPx), indicating cellular oxidative defense upregulation.
- Açaí (Euterpe oleracea Mart.) beverage consumption improves biomarkers for inflammation but not glucose- or lipid-metabolism in individuals with metabolic syndrome in a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 29850709
Açaí lowered urinary 8‑isoprostane (lipid peroxidation marker), indicating reduced oxidative cellular damage.
- Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial
PubMed ID: 34392146
Dose‑dependent reductions in oxidative stress markers (urine 8‑iso, serum MDA) and platelet activation after 12 weeks—robust cellular antioxidant protection.
- Anthocyanin complex niosome gel accelerates oral wound healing: In vitro and clinical studies
PubMed ID: 34214683
Topical anthocyanin niosome gel accelerated oral wound healing and reduced pain—protective effects at tissue/cellular level in wound milieu.
- Plasma anthocyanins and their metabolites reduce in vitro migration of pancreatic cancer cells, PANC-1, in a FAK- and NF-kB dependent manner: Results from the ATTACH-study a randomized, controlled, crossover trial in healthy subjects
PubMed ID: 36516693
Plasma after 28 days anthocyanin juice reduced pancreatic cancer cell migration and signaling ex vivo.
- An Anthocyanin- and Anti-Ageing Amino Acids-Enriched Pigmented Rice Innovation Promotes Healthy Ageing Through the Modulation of Telomere, Oxidative Stress and Inflammation Reduction: A Randomized Clinical Trial
PubMed ID: 41303396
Increased telomere/telomerase activity and reduced 8‑OHdG indicate cellular/oxidative protection.
- Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trial
PubMed ID: 37488250
Increased DHA‑LOX HDoHEs and SPM intermediates indicate pro‑resolving/cellular protective lipid signaling after exercise.
- Combination of plant phenolics and isoquinolinium alkaloids protects gingival fibroblast and improves post-extraction healing after lower third molar extraction
PubMed ID: 34617520
Topical anthocyanin formulation reduced ROS and inflammatory markers in vitro and improved post‑extraction healing clinically.
- Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidemia
PubMed ID: 32179241
12-week anthocyanin supplementation substantially decreased urinary oxidative-damage markers (8-OHdG, MDA).
- A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial
PubMed ID: 32278858
Dose-related decreases in oxidative-stress biomarkers (8-iso-PGF2α) and other markers indicate cellular oxidative protection.
Inflammation (17)
- A CONSORT-compliant, randomized, double-blind, placebo-controlled pilot trial of purified anthocyanin in patients with nonalcoholic fatty liver disease
PubMed ID: 25997043
NAFLD trial markedly reduced MPO and CK‑18 (inflammation/apoptosis markers)—meaningful anti‑inflammatory effects in liver disease.
- Açaí (Euterpe oleracea Mart.) beverage consumption improves biomarkers for inflammation but not glucose- or lipid-metabolism in individuals with metabolic syndrome in a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 29850709
Açaí reduced plasma IFN‑γ and urinary oxidative stress in metabolic‑syndrome subjects—direct anti‑inflammatory signal.
- Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial
PubMed ID: 22906565
Significant reductions in hsCRP, sVCAM-1 and IL-1β over 24 weeks — strong anti-inflammatory evidence.
- Investigation of the lipid-modifying and antiinflammatory effects of Cornus mas L. supplementation on dyslipidemic children and adolescents
PubMed ID: 23625305
Small pediatric trial with Cornus mas showed reductions in ICAM‑1 (vascular inflammation) and lipids—some anti‑inflammatory signals.
- Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients
PubMed ID: 25833778
T2D study improved adiponectin and antioxidant status and reduced HOMA‑IR, suggesting reduced inflammatory/metabolic stress.
- Sour Cherries but Not Apples Added to the Regular Diet Decrease Resting and fMLP-Stimulated Chemiluminescence of Fasting Whole Blood in Healthy Subjects
PubMed ID: 28985142
Sour cherry decreased phagocyte oxidant output, reducing a source of inflammatory oxidative activity.
- Consumption of An Anthocyanin-Rich Antioxidant Juice Accelerates Recovery of Running Economy and Indirect Markers of Exercise-Induced Muscle Damage Following Downhill Running
PubMed ID: 31547503
Anthocyanin-rich juice reduced markers of muscle damage and sped recovery after eccentric exercise (inflammatory context).
- Food anthocyanins decrease concentrations of TNF-α in older adults with mild cognitive impairment: A randomized, controlled, double blind clinical trial
PubMed ID: 33546942
High-dose juice lowered TNF-α in older adults with MCI.
- A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial
PubMed ID: 32278858
Dose-related anti-inflammatory biomarker improvements were observed in healthy young adults.
- Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidemia
PubMed ID: 32179241
Well-powered 12-week trial showed dose-dependent reductions in IL-6, TNF‑α and oxidative-inflammatory biomarkers.
- Combination of plant phenolics and isoquinolinium alkaloids protects gingival fibroblast and improves post-extraction healing after lower third molar extraction
PubMed ID: 34617520
Topical anthocyanin paste reduced ROS and inflammatory gene expression in vitro and improved oral wound healing clinically.
- Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial
PubMed ID: 34392146
12‑week reductions in platelet activation and oxidative stress imply lowered inflammatory/thrombotic activity.
- Biological effects of stevia, sucralose and sucrose in citrus-maqui juices on overweight subjects
PubMed ID: 34323244
Maqui‑citrus beverages altered IL‑10 and homocysteine depending on sweetener, indicating modulation of inflammatory markers.
- The effect of barberry (Berberis integerrima) on lipid profile and systemic inflammation in subjects with cardiovascular risk factors: a randomized controlled trial
PubMed ID: 35255880
Barberry lowered CRP and IL‑6 trend in at‑risk adults over 8 weeks.
- Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trial
PubMed ID: 37488250
Blueberry intake increased anti‑inflammatory oxylipins and decreased some pro‑inflammatory diHOMEs after muscle damage.
- Efficacy and Safety of Anthocyanin-Rich Extract in Patients with Ulcerative Colitis: A Randomized Controlled Trial
PubMed ID: 39683589
Bilberry extract significantly reduced fecal calprotectin (marker of gut inflammation) in ulcerative colitis patients.
- Synergistic Effects of Microencapsulated Polyphenols and Concurrent Training on Metabolic Health and Fitness in Overweight/Obese Adults with Prediabetes
PubMed ID: 41228432
Significant decreases in hs‑CRP and IL‑6 alongside metabolic improvements in prediabetes.
Healthy aging (14)
- An Anthocyanin- and Anti-Ageing Amino Acids-Enriched Pigmented Rice Innovation Promotes Healthy Ageing Through the Modulation of Telomere, Oxidative Stress and Inflammation Reduction: A Randomized Clinical Trial
PubMed ID: 41303396
Increased telomere/telomerase activity and skin wrinkle reduction support aging‑related benefits.
- Antiaging, Brightening, and Antioxidant Efficacy of Fermented Bilberry Extract (Vaccinium myrtillus): A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39064646
Fermented bilberry improved wrinkle depth, firmness and elasticity over 12 weeks—relevant to outward aging markers.
- Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects
PubMed ID: 19640950
Improved HDL/LDL and cholesterol efflux in dyslipidemic adults may contribute to aging-related cardiometabolic benefits.
- Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial
PubMed ID: 22906565
Long-term reductions in inflammation and improved lipids are mechanistic supports for healthy aging.
- Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia
PubMed ID: 26482148
Cognitive improvements and BP lowering in dementia patients may support aspects of healthy aging.
- Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment
PubMed ID: 29458842
Blueberry supplementation in older adults reduced everyday cognitive symptoms and improved a memory measure over 24 weeks.
- Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women
PubMed ID: 31284490
Anthocyanin/xanthophyll supplementation in obese postmenopausal women modestly raised antioxidant measures and altered metabolomics—aging‑relevant biomarkers.
- Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial
PubMed ID: 31136659
6‑month blueberry RCT in metabolic‑syndrome adults produced vascular and HDL improvements—markers relevant to healthy aging.
- Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidemia
PubMed ID: 32179241
Broad dose-dependent reductions in inflammation and oxidative stress relevant to aging biology.
- Efficacy of black rice extract on obesity in obese postmenopausal women: a 12-week randomized, double-blind, placebo-controlled preliminary clinical trial
PubMed ID: 34547006
12‑week black rice extract reduced trunk and total body fat in obese postmenopausal women—potentially favourable for age‑related metabolic health.
- Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial
PubMed ID: 34392146
Reductions in oxidative stress and platelet activation over 12 weeks support vascular/oxidative aspects of healthy aging.
- Neurocognitive Effects of Cocoa and Red-Berries Consumption in Healthy Adults
PubMed ID: 35010877
Executive function improvements in older adults after 12 weeks of polyphenols/anthocyanins suggest cognitive aging benefit.
- Effectiveness of "Moro" Blood Orange Citrus sinensis Osbeck (Rutaceae) Standardized Extract on Weight Loss in Overweight but Otherwise Healthy Men and Women-A Randomized Double-Blind Placebo-Controlled Study
PubMed ID: 35276783
Moro blood‑orange extract produced clinically meaningful weight and abdominal fat loss over 6 months, relevant to healthy aging risk reduction.
- Aronia melanocarpa extract supplementation affects brain vascular function and cognitive performance: A randomized, double-blind, placebo-controlled, cross-over study in older adults with overweight or obesity
PubMed ID: 41499921
Cognitive executive improvements in older adults and a telomere/CBF signal are suggestive of healthy‑aging effects.
Mental clarity (15)
- Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial
PubMed ID: 36972800
Blueberry RCT improved some cognitive tasks alongside vascular improvements in older adults.
- Short-term Aronia melanocarpa extract supplementation improves cognitive performance: a randomized, double-blind, placebo-controlled cross-over study in healthy young adults
PubMed ID: 38656355
Aronia improved simple reaction/movement speed and increased serum BDNF after one week.
- Blueberry Supplementation in Midlife for Dementia Risk Reduction
PubMed ID: 35458181
Executive and memory error improvements in at‑risk middle‑aged adults.
- The Positive Modulation Effect of a 6-Week Consumption of an Anthocyanin-Rich Mulberry Milk on Working Memory, Cholinergic, and Monoaminergic Functions in Healthy Working-Age Adults
PubMed ID: 34484562
Improved working‑memory tasks and lowered cortisol in working‑age adults (open‑label).
- Neurocognitive Effects of Cocoa and Red-Berries Consumption in Healthy Adults
PubMed ID: 35010877
12‑week cocoa/red‑berry anthocyanins improved executive‑function timings in older adults (objective cognitive task improvement).
- The effects of polyphenols-rich tropical fruit juice on cognitive function and metabolomics profile - a randomized controlled trial in middle-aged women
PubMed ID: 33666540
Polyphenol/anthocyanin juice improved learning/memory test scores and altered metabolomic/oxidative markers in middle‑aged women.
- Effect of Single Administration of Mulberry Milk on the Cognitive Function of 6-12-Year-Old Children: Results from a Randomized, Placebo-Controlled, Crossover Study
PubMed ID: 32685097
Acute mulberry drink improved ERP markers (N100/P300) and working memory response times, indicating clearer attention processing.
- A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans
PubMed ID: 32731478
Single-dose phenolic beverages increased frontal oxygenation (StO2) and produced some modest mood/alertness benefits — relevant to clarity.
- The effects of acute wild blueberry supplementation on the cognition of 7-10-year-old schoolchildren
PubMed ID: 30327868
Wild blueberry drink acutely preserved verbal memory and sped executive attention in children—demonstrates improved cognitive performance.
- Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment
PubMed ID: 29458842
Blueberry supplementation reduced self-reported cognitive problems and improved a recognition memory measure.
- Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia
PubMed ID: 26482148
12‑week cherry juice improved verbal fluency and memory in older adults with dementia—clear cognitive clarity benefits.
- Aronia melanocarpa extract supplementation affects brain vascular function and cognitive performance: A randomized, double-blind, placebo-controlled, cross-over study in older adults with overweight or obesity
PubMed ID: 41499921
Improved executive function with Aronia extract in older adults supports cognitive clarity.
- Wild Blueberry Extract Intervention in Healthy Older Adults: A Multi-Study, Randomised, Controlled Investigation of Acute Cognitive and Cardiovascular Effects
PubMed ID: 38674870
Acute wild blueberry produced small, dose‑ and time‑dependent improvements in executive speed in older adults.
- A Randomized, Double-Blind, Placebo-Controlled Study of an Anthocyanin-Rich Functional Ingredient on Cognitive Function and Eye Dryness in Late Adulthood Volunteers: Roles of Epigenetic and Gut Microbiome Modulations
PubMed ID: 37630690
Anthaplex improved objective EEG markers of attention (N100/P300) and working‑memory accuracy in older adults.
- An Anthocyanin- and Anti-Ageing Amino Acids-Enriched Pigmented Rice Innovation Promotes Healthy Ageing Through the Modulation of Telomere, Oxidative Stress and Inflammation Reduction: A Randomized Clinical Trial
PubMed ID: 41303396
Working memory and processing speed improvements after pigmented rice suggest clearer cognition.
Memory (14)
- Aronia melanocarpa extract supplementation affects brain vascular function and cognitive performance: A randomized, double-blind, placebo-controlled, cross-over study in older adults with overweight or obesity
PubMed ID: 41499921
Executive function (spatial working memory) improved substantially in older overweight adults.
- Blueberry Supplementation in Midlife for Dementia Risk Reduction
PubMed ID: 35458181
12‑week blueberry RCT improved executive/memory error measures in at‑risk middle‑aged adults.
- Anthocyanin intake is associated with improved memory in older adults with mild cognitive impairment
PubMed ID: 35597230
Cross‑sectional MCI data: higher habitual anthocyanin intake associated with ~2–3 more recalled words.
- Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial
PubMed ID: 36972800
12‑week blueberry RCT improved some memory/executive tasks alongside vascular benefits.
- A Randomized, Double-Blind, Placebo-Controlled Study of an Anthocyanin-Rich Functional Ingredient on Cognitive Function and Eye Dryness in Late Adulthood Volunteers: Roles of Epigenetic and Gut Microbiome Modulations
PubMed ID: 37630690
Anthaplex improved working‑memory accuracy and objective ERP markers (N100/P300) in older volunteers.
- An Anthocyanin- and Anti-Ageing Amino Acids-Enriched Pigmented Rice Innovation Promotes Healthy Ageing Through the Modulation of Telomere, Oxidative Stress and Inflammation Reduction: A Randomized Clinical Trial
PubMed ID: 41303396
Randomized trial showed improvements on several memory/working memory tests.
- Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia
PubMed ID: 26482148
12‑week cherry juice improved verbal fluency and short/long‑term memory in older adults with dementia—clinical memory improvements.
- Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment
PubMed ID: 29458842
24-week blueberry trial improved a memory-recognition measure and reduced self-reported cognitive problems in older adults.
- A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults
PubMed ID: 29882843
Stabilized wild blueberry extract modestly improved some episodic memory measures and lowered systolic BP in older adults in a large RCT.
- The effects of acute wild blueberry supplementation on the cognition of 7-10-year-old schoolchildren
PubMed ID: 30327868
Single‑dose wild blueberry drink acutely maintained verbal episodic memory and sped attention in 7–10‑year‑olds—robust pediatric memory signal.
- Effect of Single Administration of Mulberry Milk on the Cognitive Function of 6-12-Year-Old Children: Results from a Randomized, Placebo-Controlled, Crossover Study
PubMed ID: 32685097
Single‑dose mulberry (anthocyanin‑rich) improved attention ERP markers (N100/P300) and working‑memory response times in children acutely.
- The effects of polyphenols-rich tropical fruit juice on cognitive function and metabolomics profile - a randomized controlled trial in middle-aged women
PubMed ID: 33666540
12‑week polyphenol/anthocyanin‑rich tropical juice improved learning and memory test scores in middle‑aged women.
- Neurocognitive Effects of Cocoa and Red-Berries Consumption in Healthy Adults
PubMed ID: 35010877
12‑week cocoa/red‑berry trial improved executive function timing (Tower of London) in older adults—benefit attributed in part to anthocyanins.
- The Positive Modulation Effect of a 6-Week Consumption of an Anthocyanin-Rich Mulberry Milk on Working Memory, Cholinergic, and Monoaminergic Functions in Healthy Working-Age Adults
PubMed ID: 34484562
6‑week mulberry trial improved multiple working‑memory tests and lowered cortisol.
Blood sugar (12)
- A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial
PubMed ID: 32278858
Graded supplementation showed improved fasting glucose at an intermediate dose (80 mg/day).
- Anthocyanins regulate serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes: a randomized controlled trial
PubMed ID: 32930848
320 mg/day anthocyanins for 12 weeks increased adipsin, lowered visfatin and produced a small but significant HbA1c decrease in prediabetes/new diabetes.
- A CONSORT-compliant, randomized, double-blind, placebo-controlled pilot trial of purified anthocyanin in patients with nonalcoholic fatty liver disease
PubMed ID: 25997043
NAFLD RCT improved 2‑h OGTT glucose significantly—evidence for improved glucose tolerance.
- Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients
PubMed ID: 25833778
24‑week RCT in T2D reduced fasting glucose, improved HOMA‑IR and lowered triglycerides—strong metabolic/glucose regulation evidence.
- An Anthocyanin-Rich Mixed-Berry Intervention May Improve Insulin Sensitivity in a Randomized Trial of Overweight and Obese Adults
PubMed ID: 31775396
Controlled mixed-berry feeding reduced post-meal insulin AUC (glucose AUC trended down).
- Association between different dietary polyphenol subclasses and the improvement in cardiometabolic risk factors: evidence from a randomized controlled clinical trial
PubMed ID: 29151225
Observational associations in a polyphenol-rich diet study linked anthocyanidins to better early insulin secretion.
- Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes
PubMed ID: 28556578
Bilberry diet raised hippuric acid and changes correlated with lower fasting glucose and improved insulin secretion.
- Role of Purified Anthocyanins in Improving Cardiometabolic Risk Factors in Chinese Men and Women with Prediabetes or Early Untreated Diabetes-A Randomized Controlled Trial
PubMed ID: 28994705
12-week purified anthocyanins modestly lowered HbA1c in prediabetes/early diabetes — strong clinical glycemic evidence.
- Synergistic Effects of Microencapsulated Polyphenols and Concurrent Training on Metabolic Health and Fitness in Overweight/Obese Adults with Prediabetes
PubMed ID: 41228432
Strong randomized data: improved fasting glucose, HbA1c and HOMA‑IR when combined with training.
- Diabetes Therapeutics of Prebiotic Soluble Dietary Fibre and Antioxidant Anthocyanin Supplement in Patients with Type 2 Diabetes: Randomised Placebo-Controlled Clinical Trial
PubMed ID: 40218856
60‑day anthocyanin + prebiotic produced clinically meaningful reductions in FPG (−11.9%) and HbA1c (−6.7%) in T2D.
- Blueberry Supplementation in Midlife for Dementia Risk Reduction
PubMed ID: 35458181
Blueberry RCT lowered fasting insulin in at‑risk middle‑aged adults.
- Blueberry anthocyanin intake attenuates the postprandial cardiometabolic effect of an energy-dense food challenge: Results from a double blind, randomized controlled trial in metabolic syndrome participants
PubMed ID: 34883305
Single‑meal blueberry intervention in MetS patients reduced postprandial insulin and later glucose excursions and preserved HDL measures.
Eye health (8)
- A Randomized, Placebo-Controlled Study on the Safety and Efficacy of Daily Ingestion of Green Tea (Camellia sinensis L.) cv. "Yabukita" and "Sunrouge" on Eyestrain and Blood Pressure in Healthy Adults
PubMed ID: 29734777
Anthocyanin‑rich Sunrouge green tea improved ocular accommodation and reduced eyestrain in younger VDT users in a large RCT subgroup analysis.
- Purified high-dose anthocyanoside oligomer administration improves nocturnal vision and clinical symptoms in myopia subjects
PubMed ID: 16022759
High-dose anthocyanoside tablets improved nocturnal contrast sensitivity and ocular symptoms in myopic subjects—strong clinical eye benefit.
- Two-year randomized, placebo-controlled study of black currant anthocyanins on visual field in glaucoma
PubMed ID: 22377796
24-month black currant anthocyanin trial slowed visual field loss and increased ocular blood flow in open-angle glaucoma.
- Effects of black currant anthocyanins on intraocular pressure in healthy volunteers and patients with glaucoma
PubMed ID: 23046438
Oral black currant anthocyanins lowered IOP in healthy and glaucoma patients and associated with less visual field deterioration in patients.
- Blueberry effects on dark vision and recovery after photobleaching: placebo-controlled crossover studies
PubMed ID: 25335781
Blueberry anthocyanins hastened recovery of vision after photobleaching in two crossover trials—direct visual function benefit.
- Anthocyanin oligomer (grape skin extract) administration improves dry eye disease: A randomised, double-blind, placebo-controlled study
PubMed ID: 36703096
Oral anthocyanin oligomers (800 mg/day) improved tear‑breakup time and ocular surface signs/symptoms in mild–moderate dry eye (RCT, n=108).
- An Oral Polyphenol Formulation to Modulate the Ocular Surface Inflammatory Process and to Improve the Symptomatology Associated with Dry Eye Disease
PubMed ID: 35956412
Polyphenol+omega‑3 formulation (including anthocyanins) improved dry‑eye symptoms and tear stability in RCT.
- A 12-Week-Long Intake of Bilberry Extract (Vaccinium myrtillus L.) Improved Objective Findings of Ciliary Muscle Contraction of the Eye: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Trial
PubMed ID: 32106548
12-week bilberry extract RCT reduced high-frequency accommodative microfluctuation and improved ocular fatigue — direct eye benefit.
Immune support (6)
- Açaí (Euterpe oleracea Mart.) beverage consumption improves biomarkers for inflammation but not glucose- or lipid-metabolism in individuals with metabolic syndrome in a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 29850709
Metabolic‑syndrome RCT showed decreased plasma IFN-γ (inflammatory cytokine) and reduced urinary oxidative stress, indicating immune/inflammatory modulation.
- Sour Cherries but Not Apples Added to the Regular Diet Decrease Resting and fMLP-Stimulated Chemiluminescence of Fasting Whole Blood in Healthy Subjects
PubMed ID: 28985142
Sour cherry intake reduced phagocyte oxidant generation, a direct change in innate immune effector activity.
- Food anthocyanins decrease concentrations of TNF-α in older adults with mild cognitive impairment: A randomized, controlled, double blind clinical trial
PubMed ID: 33546942
High-dose anthocyanin lowered TNF-α in older adults with MCI (anti-inflammatory immune signal).
- A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial
PubMed ID: 32278858
Dose-related anti-inflammatory biomarker changes (IL-10 correlations) in healthy adults.
- Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidemia
PubMed ID: 32179241
12-week dose study in dyslipidemia produced large, dose-dependent reductions in inflammatory markers (IL-6, TNF-α).
- Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial
PubMed ID: 22906565
24-week anthocyanin trial reduced hsCRP/sVCAM-1 — anti-inflammatory changes supportive of immune health.
Weight management (5)
- Effectiveness of "Moro" Blood Orange Citrus sinensis Osbeck (Rutaceae) Standardized Extract on Weight Loss in Overweight but Otherwise Healthy Men and Women-A Randomized Double-Blind Placebo-Controlled Study
PubMed ID: 35276783
6‑month Moro blood‑orange extract RCT increased weight, waist and fat‑mass loss vs placebo.
- Antioxidative activity and health benefits of anthocyanin-rich fruit juice in healthy volunteers
PubMed ID: 31088176
Eight-week anthocyanin-rich juice slightly reduced body fat vs placebo — direct weight composition signal.
- Anthocyanin Rich-Black Soybean Testa Improved Visceral Fat and Plasma Lipid Profiles in Overweight/Obese Korean Adults: A Randomized Controlled Trial
PubMed ID: 27809637
Black soybean testa reduced abdominal fat measures and improved several lipid measures in overweight adults.
- Synergistic Effects of Microencapsulated Polyphenols and Concurrent Training on Metabolic Health and Fitness in Overweight/Obese Adults with Prediabetes
PubMed ID: 41228432
Improvements in glycemia, lipids and fitness with concurrent training support weight management.
- Efficacy of black rice extract on obesity in obese postmenopausal women: a 12-week randomized, double-blind, placebo-controlled preliminary clinical trial
PubMed ID: 34547006
12‑week black rice extract reduced trunk and total body fat in obese postmenopausal women (randomized double‑blind).
Gut health (5)
- Plasma and Urinary (Poly)phenolic Profiles after 4-Week Red Raspberry (Rubus idaeus L.) Intake with or without Fructo-Oligosaccharide Supplementation
PubMed ID: 33080934
4‑week red raspberry intake shifted circulating phenolic profile toward gut‑derived urolithins/valerolactones—clear interaction with gut microbial metabolism.
- Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following Two Weeks of Flavonoid Supplementation
PubMed ID: 30423955
Flavonoid supplementation plus acute exercise increased circulating gut‑derived phenolic metabolites and showed altered gut permeability signals (L/M ratio differences).
- Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes
PubMed ID: 28556578
Bilberry diet raised fasting hippuric acid (microbial-derived metabolite), changes correlated with improved glucose and insulin secretion.
- Gut enterotype- and body mass index (BMI)-dependent effects of anthocyanin supplementation on gut microbiota composition in individuals at risk for cognitive decline: a randomized placebo-controlled trial
PubMed ID: 41163367
24‑week RCT showed host‑dependent selective genus‑level shifts in gut microbiota composition.
- Efficacy and Safety of Anthocyanin-Rich Extract in Patients with Ulcerative Colitis: A Randomized Controlled Trial
PubMed ID: 39683589
Bilberry extract reduced fecal calprotectin in moderate–severe ulcerative colitis, indicating a beneficial gut‑inflammatory effect.
Skin appearance (5)
- Combination of plant phenolics and isoquinolinium alkaloids protects gingival fibroblast and improves post-extraction healing after lower third molar extraction
PubMed ID: 34617520
Anthocyanin‑rich topical paste reduced ROS/IL‑6/COX‑2 in vitro and improved post‑extraction healing clinically—supports skin/tissue recovery.
- Anthocyanin complex niosome gel accelerates oral wound healing: In vitro and clinical studies
PubMed ID: 34214683
Topical anthocyanin niosome gel accelerated oral wound closure and reduced pain — topical healing benefit translatable to skin/tissue radiance context.
- Improvement on blood pressure and skin using roselle drink: A clinical trial
PubMed ID: 35758855
Roselle increased facial skin moisture and redness after 6 months.
- Antiaging, Brightening, and Antioxidant Efficacy of Fermented Bilberry Extract (Vaccinium myrtillus): A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39064646
Fermented bilberry extract over 12 weeks reduced wrinkle depth and improved firmness/elasticity and skin antioxidant capacity in a randomized trial.
- An Anthocyanin- and Anti-Ageing Amino Acids-Enriched Pigmented Rice Innovation Promotes Healthy Ageing Through the Modulation of Telomere, Oxidative Stress and Inflammation Reduction: A Randomized Clinical Trial
PubMed ID: 41303396
Dose‑dependent reduction in facial wrinkles observed with pigmented anthocyanin rice.
Mood balance (4)
- The Positive Modulation Effect of a 6-Week Consumption of an Anthocyanin-Rich Mulberry Milk on Working Memory, Cholinergic, and Monoaminergic Functions in Healthy Working-Age Adults
PubMed ID: 34484562
Lowered salivary cortisol and improved working‑memory may indicate stress/mood benefits (open‑label).
- A biphasic response to blueberry supplementation on depressive symptoms in emerging adults: a double-blind randomized controlled trial
PubMed ID: 38300292
Acute blueberry improved positive affect and task accuracy; chronic mood findings were mixed (unexpected poorer long‑term depression recovery).
- A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans
PubMed ID: 32731478
Single-dose beverages with phenolic extracts improved several mood measures (POMS/alertness/fatigue) and increased frontal oxygenation.
- Effect of Single Administration of Mulberry Milk on the Cognitive Function of 6-12-Year-Old Children: Results from a Randomized, Placebo-Controlled, Crossover Study
PubMed ID: 32685097
Single‑dose mulberry reduced salivary cortisol (stress marker) and improved attention-related ERPs acutely — suggests stress/mood modulation.
Exercise recovery (4)
- Consumption of An Anthocyanin-Rich Antioxidant Juice Accelerates Recovery of Running Economy and Indirect Markers of Exercise-Induced Muscle Damage Following Downhill Running
PubMed ID: 31547503
Double-blind RCT showed faster recovery of running economy, muscle function, and lower CK after anthocyanin-rich juice.
- Synergistic Effects of Microencapsulated Polyphenols and Concurrent Training on Metabolic Health and Fitness in Overweight/Obese Adults with Prediabetes
PubMed ID: 41228432
Combined anthocyanin + training improved fitness and metabolic recovery markers beyond control.
- Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trial
PubMed ID: 37488250
Blueberry intake shifted oxylipins toward anti‑inflammatory/SPM intermediates after muscle‑damaging exercise (biomarker evidence for recovery/resolution).
- Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction: an open-label randomized clinical trial
PubMed ID: 30803503
Bilberry supplementation after MI increased 6‑minute walk distance (functional exercise capacity) and reduced oxidative stress.
Liver support (3)
- Intake of purple sweet potato beverage affects on serum hepatic biomarker levels of healthy adult men with borderline hepatitis
PubMed ID: 17299464
Purple sweet potato beverage rich in acylated anthocyanins decreased GGT and other liver enzymes in men with borderline hepatitis—direct liver enzyme improvement.
- A CONSORT-compliant, randomized, double-blind, placebo-controlled pilot trial of purified anthocyanin in patients with nonalcoholic fatty liver disease
PubMed ID: 25997043
Purified anthocyanins in NAFLD significantly reduced ALT, CK‑18 (apoptosis) and improved 2‑h glucose and MPO—direct liver injury improvements.
- Double-blind, placebo-controlled pilot trial of anthocyanin-rich purple sweet potato beverage on serum hepatic biomarker levels in healthy Caucasians with borderline hepatitis
PubMed ID: 27530473
Purple sweet potato beverage reduced GGT, AST and ALT over 43 days in people with borderline hepatitis — direct hepatic biomarker improvements.
Urinary comfort (1)
- Black chokeberry juice (Aronia melanocarpa) reduces incidences of urinary tract infection among nursing home residents in the long term--a pilot study
PubMed ID: 25026919
Pilot crossover in nursing‑home residents showed fewer treated UTIs during chokeberry juice periods—direct UTI reduction signal.
Similar by evidence
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Products with Anthocyanins
Search all71 products whose verified label declares Anthocyanins — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.