Isoleucine
13 benefits mapped to clinical evidence across supplements.
Dose per serving from products
1,261 products in our catalogue print how much Isoleucine a serving holds.
Most common: 1 g to 2.5 g, 52% of 1,261 products.
| Dose per serving | Products |
|---|---|
| 50 mg or less | 42 |
| 50 mg to 100 mg | 38 |
| 100 mg to 250 mg | 121 |
| 250 mg to 500 mg | 113 |
| 500 mg to 1 g | 238 |
| 1 g to 2.5 g | 650 |
| over 2.5 g | 59 |
Dose per serving from research
8 study groups in 6 studies say how much Isoleucine participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 g to 2.5 g and 10 g to 25 g, 25% of 8 study groups each.
| Daily dose | Study groups |
|---|---|
| 5 mg or less | 1 |
| 5 mg to 10 mg | 0 |
| 10 mg to 25 mg | 1 |
| 25 mg to 50 mg | 0 |
| 50 mg to 100 mg | 0 |
| 100 mg to 250 mg | 0 |
| 250 mg to 500 mg | 0 |
| 500 mg to 1 g | 1 |
| 1 g to 2.5 g | 2 |
| 2.5 g to 5 g | 0 |
| 5 g to 10 g | 0 |
| 10 g to 25 g | 2 |
| over 25 g | 1 |
Commonly used together
6 of 7 study groups took Isoleucine with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Leucine | 5 |
Benefit Evidence
âBCAAs, âweight loss
âhunger, âintake
âsatiety hormones
Amino acids â hunger
Amino acids â intake
Amino acids â satiety
Research sources
Metabolism (14)
- Digitally enhanced ketogenic diet versus low-fat diet for cardio-renal-metabolic health in a predominantly Hispanic adult population with overweight or obesity: Pilot randomised clinical trial
PubMed ID: 40770907
Diet interventions reduced BCAAs (including isoleucine) alongside weight and HbA1c improvements â supports metabolic associations with BCAA changes.
- Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial
PubMed ID: 29633349
Metformin users had altered circulating leucine/isoleucine â demonstrates BCAA links to metabolic drug effects (human, moderate strength).
- Diabetes Remission Is Modulated by Branched Chain Amino Acids According to the Diet Consumed: From the CORDIOPREV Study
PubMed ID: 34863046
PostâOGTT isoleucine predicted T2DM remission on Mediterranean diet (observational predictive association).
- Lactotripeptides effect on office and 24-h ambulatory blood pressure, blood pressure stress response, pulse wave velocity and cardiac output in patients with high-normal blood pressure or first-degree hypertension: a randomized double-blind clinical trial
PubMed ID: 21753776
Lactotripeptides (IPP) trial: modest reductions in office systolic BP and arterial stiffness in highânormal/mild hypertensives.
- Predictors of the short-term effect of isoleucine-proline-proline/valine-proline-proline lactotripeptides from casein on office and ambulatory blood pressure in subjects with pharmacologically untreated high-normal blood pressure or first-degree hypertension
PubMed ID: 22574612
Large shortâterm trial of IPP/VPP showed modest office BP reductions (metabolic/CV relevance).
- Effect of Lactotripeptides (Isoleucine-Proline-Proline/Valine-Proline-Proline) on Blood Pressure and Arterial Stiffness Changes in Subjects with Suboptimal Blood Pressure Control and Metabolic Syndrome: A Double-Blind, Randomized, Crossover Clinical Trial
PubMed ID: 26683986
Lactotripeptides (contain Ile) improved BP and arterial stiffness in metabolicâsyndrome patients (physiologic metabolic benefit).
- A novel nutritional supplement containing amino acids and chromium decreases postprandial glucose response in a randomized, double-blind, placebo-controlled study
PubMed ID: 32579549
Multiâaminoâacid+chromium drink acutely reduced postprandial glucose (human RCT) â product contains multiple AAs including isoleucine (not isoleucineâonly).
- Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men
PubMed ID: 15288885
Randomized trial: lactotripeptide (IPP/VPP, contains isoleucine) in sour milk reduced office systolic BP by ~4â5 mmHgâcardiometabolic benefit.
- Additive beneficial effects of lactotripeptides and aerobic exercise on arterial compliance in postmenopausal women
PubMed ID: 19783777
Postmenopausal RCT: lactotripeptides improved carotid arterial compliance, especially with exerciseâfavors vascular/metabolic health.
- IPP-rich milk protein hydrolysate lowers blood pressure in subjects with stage 1 hypertension, a randomized controlled trial
PubMed ID: 21059213
IPPârich milk peptide modestly lowered clinic BP in stageâ1 hypertensives (metabolic CV risk improvement).
- Weight-loss diets and 2-y changes in circulating amino acids in 2 randomized intervention trials
PubMed ID: 26791187
Weightâloss diets lowered circulating BCAAs (incl. isoleucine) that tracked with weight loss and improved insulin resistance (observational link to metabolic health).
- Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease
PubMed ID: 34382947
Randomized trial of AXA1125 (multiâAA including isoleucine) produced meaningful reductions in liver fat and improved HOMAâIR in NAFLD.
- Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium breve BBr60 Intervention: A Randomized Controlled Trial
PubMed ID: 39456659
Probiotic trial produced weight/BMI reductions and shifted valine/leucine/isoleucine metabolic pathwaysâindirect metabolic benefit tied to Ile pathways.
- Postprandial Glucose and Gastrointestinal Hormone Responses of Healthy Subjects to Wheat Biscuits Enriched with L-Arginine or Branched-Chain Amino Acids of Plant Origin
PubMed ID: 36297065
Acute BCAAâenriched biscuit (incl. Ile) lowered postprandial glucose iAUC and altered insulin/GLPâ1 responses.
Protein source (12)
- Postprandial Glucose and Gastrointestinal Hormone Responses of Healthy Subjects to Wheat Biscuits Enriched with L-Arginine or Branched-Chain Amino Acids of Plant Origin
PubMed ID: 36297065
BCAAâenriched biscuits produced clear, significant rises in plasma isoleucine/leucine/valine (direct replenishment evidence).
- Biomarkers of Frailty in Patients with Advanced Chronic Liver Disease Undergoing a Multifactorial Intervention Consisting of Home Exercise, Branched-Chain Amino Acids, and Probiotics
PubMed ID: 39595586
Intervention including BCAA increased serum isoleucine and valine in cirrhotic patients.
- Parenteral administration of different amounts of branch-chain amino acids in septic patients: clinical and metabolic aspects
PubMed ID: 9118656
BCAAâenriched parenteral nutrition increased plasma valine/leucine/isoleucine in septic patients.
- Effects of Astragalus membranaceus and Panax notoginseng Saponins Extract on the Pharmacokinetics of Whey Protein Absorption, Intestinal Permeability, and Muscle Function: A Pilot Study
PubMed ID: 41683325
APS plant extracts increased AUC/Cmax of BCAAs (including isoleucine) from whey in humans, enhancing isoleucine bioavailability.
- Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet
PubMed ID: 33513734
Infant higher-protein complementary foods raised serum isoleucine over the intervention period.
- Metabolic effects of keto acid--amino acid supplementation in patients with chronic renal insufficiency receiving a low-protein diet and recombinant human erythropoietin--a randomized controlled trial
PubMed ID: 11603100
Keto-acid/amino-acid supplementation in CKD raised plasma isoleucine (and other BCAAs) significantly.
- Branched-chain amino acid requirements for enterally fed term neonates in the first month of life
PubMed ID: 24284437
Tracer study in term neonates precisely quantified isoleucine requirement (direct relevance to replenishment needs).
- Enhanced nutrient supply to very low birth weight infants is associated with higher blood amino acid concentrations and improved growth
PubMed ID: 29132733
Enhanced nutrient supply raised blood BCAAs and improved growth in VLBW infants (direct replenishment signal).
- Protein bioavailability of Wolffia globosa duckweed, a novel aquatic plant - A randomized controlled trial
PubMed ID: 30591380
Mankai meal increased postprandial essential AAs including isoleucine, showing dietary replenishment from this source.
- Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic Lactobacillus paracasei PS23 for the Treatment of Sarcopenia in Elderly Subjects: A 2-Month Randomized Double-Blind Placebo-Controlled Trial
PubMed ID: 36364828
Multinutrient product increased circulating BCAAs (valine, leucine, isoleucine) in sarcopenic elderly (intervention evidence).
- Late evening snack and oral amino acid capsules improved respiratory quotient and Fischer ratio in patients with alcoholic liver cirrhosis
PubMed ID: 36007871
Late evening snack + oral amino acids markedly increased serum isoleucine and Fischer ratio in cirrhosis patients (clear replenishment effect).
- Effects of feeding low protein diets to piglets on plasma urea nitrogen, faecal ammonia nitrogen, the incidence of diarrhoea and performance after weaning
PubMed ID: 18942582
Crystalline isoleucine supplementation in piglets directly manipulated isoleucine intake and reduced plasma urea nitrogenâdemonstrates replenishment and utilization (animal model).
Vitality (8)
- Parenteral administration of different amounts of branch-chain amino acids in septic patients: clinical and metabolic aspects
PubMed ID: 9118656
BCAAâenriched PN improved anabolic markers, nitrogen balance and was associated with lower ICU mortalityâbroad vitality signal in critical illness.
- Enhanced nutrient supply to very low birth weight infants is associated with higher blood amino acid concentrations and improved growth
PubMed ID: 29132733
Enhanced nutrient/AA supply increased BCAAs and produced meaningful growth in VLBW infants (improved clinical vitality).
- Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic Lactobacillus paracasei PS23 for the Treatment of Sarcopenia in Elderly Subjects: A 2-Month Randomized Double-Blind Placebo-Controlled Trial
PubMed ID: 36364828
Multinutrient supplement increased BCAAs and improved physical function in sarcopenic elderly â supports improved vitality/function.
- Late evening snack and oral amino acid capsules improved respiratory quotient and Fischer ratio in patients with alcoholic liver cirrhosis
PubMed ID: 36007871
Late snack + oral AAs in cirrhosis raised serum isoleucine and Fischer ratio and improved metabolic fuel use (clinically meaningful improvement in frail patients).
- Association of leucine and other branched chain amino acids with clinical outcomes in malnourished inpatients: a secondary analysis of the randomized clinical trial EFFORT
PubMed ID: 39245679
Low plasma BCAAs (including isoleucine) linked to higher 180âday mortality in malnourished inpatients (observational evidence that adequate BCAAs relate to resilience/vitality).
- Metabolome and microbiome alterations related to short-term feeding of a micronutrient-fortified, high-quality legume protein-based food product to stunted school age children: A randomized controlled pilot trial
PubMed ID: 32139110
Fortified legume snack increased shortâterm linear growth and IGFâ1 in stunted children â supports child vitality and growth.
- Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease
PubMed ID: 34382947
AXA1125 improved liver fat and insulin resistance in NAFLD â clinically meaningful metabolic/vitality improvements (multiâAA product).
- Biomarkers of Frailty in Patients with Advanced Chronic Liver Disease Undergoing a Multifactorial Intervention Consisting of Home Exercise, Branched-Chain Amino Acids, and Probiotics
PubMed ID: 39595586
Exercise + BCAA + probiotic program improved frailty and inflammation in cirrhosis (global functional/vitality benefit).
Weight management (5)
- Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind Study
PubMed ID: 31480676
Whey (BCAA-rich) for 8 weeks modestly reduced android fat and increased nesfatin (satiety hormone) in overweight women (human RCT).
- Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium breve BBr60 Intervention: A Randomized Controlled Trial
PubMed ID: 39456659
Randomized probiotic intervention yielded significant weight and BMI loss and altered Ile/BCAA metabolic pathways.
- Weight-loss diets and 2-y changes in circulating amino acids in 2 randomized intervention trials
PubMed ID: 26791187
Circulating BCAAs (including isoleucine) decreased with weight loss and correlated with improved insulin resistance (observational link to dieting effects).
- Differential effects of dairy snacks on appetite, but not overall energy intake
PubMed ID: 22380537
Dairy snack (yogurt) raised plasma isoleucine and suppressed hunger and reduced ad libitum lunch intake (supports appetite/weight control).
- Digitally enhanced ketogenic diet versus low-fat diet for cardio-renal-metabolic health in a predominantly Hispanic adult population with overweight or obesity: Pilot randomised clinical trial
PubMed ID: 40770907
Both dietary programs reduced BCAAs (including isoleucine) and improved body weight in overweight adults â supports association of BCAA changes with weight loss.
Body composition (7)
- Parenteral administration of different amounts of branch-chain amino acids in septic patients: clinical and metabolic aspects
PubMed ID: 9118656
BCAAâenriched PN increased anabolic markers and improved nitrogen balance in ICU patientsâsupports lean mass maintenance in catabolic states.
- Enhanced nutrient supply to very low birth weight infants is associated with higher blood amino acid concentrations and improved growth
PubMed ID: 29132733
Enhanced aminoâacid supply increased growth velocity in VLBW infants, consistent with lean mass/weight gain support.
- Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic Lactobacillus paracasei PS23 for the Treatment of Sarcopenia in Elderly Subjects: A 2-Month Randomized Double-Blind Placebo-Controlled Trial
PubMed ID: 36364828
Multinutrient supplement prevented appendicular lean mass loss and improved function in sarcopenic elderly (RCT, clinically meaningful).
- Anti-sarcopenic effect of leucine-enriched branched-chain amino acid supplementation among elderly chronic kidney disease patients: a double-blinded randomized controlled trial
PubMed ID: 40381110
Leucineâenriched BCAA increased lean muscle mass in elderly CKD patients compared with placebo (RCT evidence).
- [The effects of recombinant human growth hormone on the metabolism of branch chain amino acid in severely burned patients]
PubMed ID: 12467536
Burn patients: interventions that improved BCAA dynamics and lowered muscle breakdown are consistent with maintaining/recuperating lean mass in catabolic states.
- Biomarkers of Frailty in Patients with Advanced Chronic Liver Disease Undergoing a Multifactorial Intervention Consisting of Home Exercise, Branched-Chain Amino Acids, and Probiotics
PubMed ID: 39595586
Multicomponent program including BCAA increased BCAAs and improved frailty/strength in cirrhosisâsupportive of lean mass maintenance.
- Estimation of the optimum ratio of standardized ileal digestible isoleucine to lysine for eight- to twenty-five-kilogram pigs in diets containing spray-dried blood cells or corn gluten feed as a protein source
PubMed ID: 19329472
Doseâresponse in pigs: optimal digestible Ile:Lys increased ADG and nitrogen retention, supporting maintenance/gain of lean mass in an animal model.
Muscle growth (7)
- [The effects of recombinant human growth hormone on the metabolism of branch chain amino acid in severely burned patients]
PubMed ID: 12467536
Burn patients: rhGH accelerated rise in plasma BCAAs and reduced urinary 3âmethylhistidine (less muscle breakdown), supporting net muscle anabolism in injury context.
- Anti-sarcopenic effect of leucine-enriched branched-chain amino acid supplementation among elderly chronic kidney disease patients: a double-blinded randomized controlled trial
PubMed ID: 40381110
Leucineâenriched BCAA increased lean mass in elderly CKD patients (RCT) â strong evidence for BCAA mix improving lean mass (not isoleucineâonly).
- Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic Lactobacillus paracasei PS23 for the Treatment of Sarcopenia in Elderly Subjects: A 2-Month Randomized Double-Blind Placebo-Controlled Trial
PubMed ID: 36364828
Multinutrient (including leucine) for 2 months increased plasma BCAAs and improved appendicular lean mass and physical performance in sarcopenic elderly (RCT, clinically meaningful).
- Parenteral administration of different amounts of branch-chain amino acids in septic patients: clinical and metabolic aspects
PubMed ID: 9118656
BCAAâenriched parenteral nutrition increased plasma BCAAs and anabolic/protein markers and improved nitrogen balance in septic patientsâdirect evidence for protein synthesis support.
- Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trial
PubMed ID: 24284442
High-leucine added to a low-protein drink restored myofibrillar protein synthesis to near full whey levels â demonstrates supplementation can drive MPS.
- Biomarkers of Frailty in Patients with Advanced Chronic Liver Disease Undergoing a Multifactorial Intervention Consisting of Home Exercise, Branched-Chain Amino Acids, and Probiotics
PubMed ID: 39595586
Intervention including BCAA increased BCAA levels and improved frailty/strength in cirrhotics.
- Enhanced nutrient supply to very low birth weight infants is associated with higher blood amino acid concentrations and improved growth
PubMed ID: 29132733
Enhanced nutrient (including AA) supply raised BCAAs and substantially improved growth in very low birthweight infants (clinically meaningful growth).
Nutrition source (6)
- Parenteral administration of different amounts of branch-chain amino acids in septic patients: clinical and metabolic aspects
PubMed ID: 9118656
BCAAâenriched parenteral formulas markedly improved nitrogen balance and anabolic proteins in septic ICU patients.
- Estimation of the optimum ratio of standardized ileal digestible isoleucine to lysine for eight- to twenty-five-kilogram pigs in diets containing spray-dried blood cells or corn gluten feed as a protein source
PubMed ID: 19329472
Titrating digestible isoleucine in pig diets increased nitrogen retention linearly, indicating direct effects on nitrogen economy (animal model).
- Metabolic effects of keto acid--amino acid supplementation in patients with chronic renal insufficiency receiving a low-protein diet and recombinant human erythropoietin--a randomized controlled trial
PubMed ID: 11603100
Keto-acid/amino-acid supplementation increased albumin and mitigated decline in creatinine clearance, consistent with improved protein/nitrogen status in CKD patients.
- Branched-chain amino acid requirements for enterally fed term neonates in the first month of life
PubMed ID: 24284437
Neonatal isoleucine requirement data inform provision to maintain nitrogen balance in term neonates.
- Effects of feeding low protein diets to piglets on plasma urea nitrogen, faecal ammonia nitrogen, the incidence of diarrhoea and performance after weaning
PubMed ID: 18942582
Crystalline isoleucine in lowâprotein piglet diets reduced plasma urea nitrogen (marker of nitrogen sparing) and lessened diarrhoeaâstrong animal evidence for improved N economy.
- Effect of decreasing ideal protein levels on performance results and nitrogen efficiency of growing-finishing gilts
PubMed ID: 20496857
Growing pig trial: varying ideal protein levels changed nitrogen efficiency and excretionârelevant to nitrogen balance when adjusting essential AAs (including isoleucine).
Blood sugar (4)
- Postprandial Glucose and Gastrointestinal Hormone Responses of Healthy Subjects to Wheat Biscuits Enriched with L-Arginine or Branched-Chain Amino Acids of Plant Origin
PubMed ID: 36297065
BCAAâenriched biscuits raised plasma Ile and reduced postprandial glucose iAUC, with insulin/GLPâ1 modulation.
- A novel nutritional supplement containing amino acids and chromium decreases postprandial glucose response in a randomized, double-blind, placebo-controlled study
PubMed ID: 32579549
Multiâaminoâacid+chromium drink acutely reduced postprandial glucose excursions in overweight adults (RCT) â clinically meaningful though not isoleucineâonly.
- Weight-loss diets and 2-y changes in circulating amino acids in 2 randomized intervention trials
PubMed ID: 26791187
Weightâloss diets that reduced BCAAs (incl. isoleucine) were associated with improved insulin resistance (HOMAâIR) in large trials (associative evidence).
- Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease
PubMed ID: 34382947
AXA1125 (multiâAA including Ile) improved insulin resistance (HOMAâIR) in NAFLD patients.
Immune support (6)
- [Impact of intravenous nutrition on plasma free amino acid spectrum and immune function for patients with sepsis]
PubMed ID: 17571315
Septic patients given parenteral AAs (including isoleucine) showed rises in IgM/C3/C4 alongside increased plasma isoleucine.
- Biomarkers of Frailty in Patients with Advanced Chronic Liver Disease Undergoing a Multifactorial Intervention Consisting of Home Exercise, Branched-Chain Amino Acids, and Probiotics
PubMed ID: 39595586
Multicomponent program including BCAA raised BCAAs and reduced CRP/LBP/sCD163 (inflammation markers) in cirrhosis.
- Parenteral administration of different amounts of branch-chain amino acids in septic patients: clinical and metabolic aspects
PubMed ID: 9118656
BCAAâenriched PN in septic patients reduced inflammation markers/nitrogen loss and was associated with lower mortalityâsupports immune/host resilience.
- L-isoleucine-supplemented oral rehydration solution in the treatment of acute diarrhoea in children: a randomized controlled trial
PubMed ID: 21766553
Isoleucineâsupplemented ORS raised stool betaâdefensinâ3 and reduced stool output in children, suggesting enhanced mucosal antimicrobial response.
- Local rhamnosoft, ceramides and L-isoleucine in atopic eczema: a randomized, placebo controlled trial
PubMed ID: 24750568
Topical product containing Lâisoleucine improved atopic eczema severity (product had antimicrobial/AMPâmodulating activity).
- Metabolic impact of low dose IL-2 therapy for primary SjĂśgren's Syndrome in a double-blind, randomized clinical trial
PubMed ID: 39482484
Human RCT: serum isoleucine tracked with lowâdose ILâ2 response and baseline isoleucine predicted clinical immune response.
Tissue repair (5)
- Anti-sarcopenic effect of leucine-enriched branched-chain amino acid supplementation among elderly chronic kidney disease patients: a double-blinded randomized controlled trial
PubMed ID: 40381110
Leucineâenriched BCAA increased lean mass in elderly CKD patients â suggests improved muscle anabolism/repair over 12 weeks.
- Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trial
PubMed ID: 24284442
Supplementing low-protein drink with leucine increased myofibrillar protein synthesis to near-whey levels â reparative anabolic effect in muscle.
- Parenteral administration of different amounts of branch-chain amino acids in septic patients: clinical and metabolic aspects
PubMed ID: 9118656
BCAAâenriched nutrition improved nitrogen balance and anabolic markers in septic patientsâfavors repair processes.
- [The effects of recombinant human growth hormone on the metabolism of branch chain amino acid in severely burned patients]
PubMed ID: 12467536
In severely burned patients rhGH altered BCAA timing and reduced urinary 3âMH (marker of muscle proteolysis), supporting muscle repair processes.
- Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic Lactobacillus paracasei PS23 for the Treatment of Sarcopenia in Elderly Subjects: A 2-Month Randomized Double-Blind Placebo-Controlled Trial
PubMed ID: 36364828
Multinutrient intervention increased BCAAs and improved functional muscle outcomes in sarcopenic elderly (supports repair/adaptation).
Muscle maintenance (3)
- Parenteral administration of different amounts of branch-chain amino acids in septic patients: clinical and metabolic aspects
PubMed ID: 9118656
BCAAâenriched parenteral nutrition improved nitrogen balance and anabolic markers in septic patientsâstrong evidence for reduced catabolism.
- Estimation of the optimum ratio of standardized ileal digestible isoleucine to lysine for eight- to twenty-five-kilogram pigs in diets containing spray-dried blood cells or corn gluten feed as a protein source
PubMed ID: 19329472
In pigs, increasing digestible isoleucine increased nitrogen retention, implying reduced net breakdown and improved protein accretion (animal model).
- [The effects of recombinant human growth hormone on the metabolism of branch chain amino acid in severely burned patients]
PubMed ID: 12467536
In burn patients rhGH caused earlier peaks in plasma BCAAs and lower urinary 3âMH (marker of muscle breakdown) versus controls.
Appetite regulation (3)
- Postprandial Glucose and Gastrointestinal Hormone Responses of Healthy Subjects to Wheat Biscuits Enriched with L-Arginine or Branched-Chain Amino Acids of Plant Origin
PubMed ID: 36297065
BCAAâenriched biscuit altered GLPâ1 and insulin responses postprandiallyâpotential to influence satiety/appetite signaling.
- Differential effects of dairy snacks on appetite, but not overall energy intake
PubMed ID: 22380537
Yogurt raised plasma isoleucine more than other dairy and produced greater hunger suppression and reduced subsequent intake versus water (supports appetite regulation).
- Mycoprotein reduces energy intake and postprandial insulin release without altering glucagon-like peptide-1 and peptide tyrosine-tyrosine concentrations in healthy overweight and obese adults: a randomised-controlled trial
PubMed ID: 27198187
High-dose mycoprotein acutely reduced ad libitum energy intake by ~10% â shows amino-acid/protein-containing meal effect on appetite (mycoprotein rather than isolated isoleucine).
Exercise recovery (1)
- Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trial
PubMed ID: 24284442
High-leucine supplementation restored muscle protein synthesis after exercise to levels similar to higher-protein whey â supports recovery of contractile protein.
Similar by evidence
Supplements the same benefits carry qualifying findings for â a fact about the evidence graph, not a recommendation to swap.
Products with Isoleucine
Search all1748 products whose verified label declares Isoleucine â not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet â this is what the field is asking, not what it found.