Chitosan
18 benefits mapped to clinical evidence across supplements.
Dose per serving from products
42 products in our catalogue print how much Chitosan a serving holds.
Most common: 500 mg to 1 g, 40% of 42 products.
| Dose per serving | Products |
|---|---|
| 100 mg or less | 1 |
| 100 mg to 250 mg | 11 |
| 250 mg to 500 mg | 5 |
| 500 mg to 1 g | 17 |
| 1 g to 2.5 g | 7 |
| over 2.5 g | 1 |
Dose per serving from research
21 study groups in 15 studies say how much Chitosan participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 g to 2.5 g, 48% of 21 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mg or less | 1 |
| 250 mg to 500 mg | 2 |
| 500 mg to 1 g | 1 |
| 1 g to 2.5 g | 10 |
| 2.5 g to 5 g | 7 |
Benefit Evidence
less inflammation, pain
â50% swelling, better healing
lower cytokines, skin redness
Healing + infectionâ
Pain/swellingâ, healingâ
Skin rednessâ, hydrationâ
Digestibility â, feed efficiency
Iron absorption â 14%
GI symptoms/adhesions â
Faster bowel return -0.9d
Lower blockage/adhesions -32%
Reduced infection -26%
More weight loss, less regain
Hormone shifts, â3.6kg, â5cm
Modest fat loss, â2.8lb
less inflammation, pain
â50% swelling, better healing
lower cytokines, skin redness
Healing + infectionâ
Pain/swellingâ, healingâ
Skin rednessâ, hydrationâ
Digestibility â, feed efficiency
Iron absorption â 14%
GI symptoms/adhesions â
Faster bowel return -0.9d
Lower blockage/adhesions -32%
Reduced infection -26%
More weight loss, less regain
Hormone shifts, â3.6kg, â5cm
Modest fat loss, â2.8lb
Research sources
Skin repair (30)
- Efficacy and safety of the combination of isosorbide dinitrate spray and chitosan gel for the treatment of diabetic foot ulcers: A double-blind, randomized, clinical trial
PubMed ID: 29682995
Randomized doubleâblind trial in diabetic foot ulcers: chitosan (alone/with isosorbide) improved wound closure percentages and complete closures vs placebo (direct wound healing evidence in compromised skin).
- Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
PubMed ID: 32683390
Splitâmouth RCT demonstrating dramatic improvements in wound healing after extraction with chitosanâcontaining gel (strong human wound recovery evidence).
- Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery
PubMed ID: 26471464
Randomized crossover trial: chitosanâcontaining gel reduced pain/inflammation and improved wound cicatrization after molar extractions (human healing benefit).
- Efficacy of chitosan powder in reducing vaginal bleeding following a loop electrosurgical excision procedure: A randomized control trial
PubMed ID: 39614700
Topical chitosan powder after LEEP significantly reduced early blood loss, fewer late bleeding events, and improved cervical wound healing (randomized trial).
- Effect of a Thermosensitive Hydroxybutyl Chitosan Hydrogel on Postoperative Sequalae and Quality of Life After Impacted Mandibular Third Molar Extraction
PubMed ID: 38971179
Hydroxybutyl chitosan hydrogel in extraction sockets reduced postoperative pain and swelling and improved early QOLâsupports oral wound recovery.
- A Chitosan-Coated Chamomile Microparticles Formulation to Prevent Radiodermatitis in Breast: A Double-blinded, Controlled, Randomized, Phase II Clinical Trial
PubMed ID: 35393979
Topical chitosan-coated chamomile improved healing of radiation-induced skin toxicity and delayed onset of more severe dermatitis.
- A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 37668810
Chitosanâbased doxepin nanogel accelerated recovery from chemotherapyâinduced oral mucositis versus control (strong topical mucosal wound recovery evidence).
- The efficacy of a novel chitosan gel on hemostasis and wound healing after endoscopic sinus surgery
PubMed ID: 20109331
RDB human trial: chitosan/dextran gel produced much faster hemostasis and far fewer postoperative adhesions after sinus surgery (clear surgical wound management benefit).
- USage of chitosan for Femoral (USF) haemostasis after percutaneous procedures: a comparative open label study
PubMed ID: 21518684
Randomized trial: HemCon pad shortened femoral artery hemostasis time (~â33%) and trended to fewer hematomasâmeaningful hemostasis/wound benefit.
- A randomised controlled trial on the effectiveness of an advanced wound dressing used in Iran
PubMed ID: 18705234
Randomized trial: chitosan-containing bioactive dressing greatly increased healing rates and prevented infections versus gauze in chronic wounds.
- [Chitosan pads vs. manual compression to control bleeding sites after transbrachial arterial catheterization in a randomized trial]
PubMed ID: 16123873
Chitosan pads accelerated hemostasis and reduced hematomas after catheter removal, clinically meaningful for wound/bleeding management.
- Reduction of postoperative adhesions by N,O-carboxymethylchitosan: a pilot study
PubMed ID: 12969711
Intraperitoneal N,O-carboxymethylchitosan reduced postoperative adhesion recurrence and tended to reduce extent/severity (surgical recovery relevance).
- [Preventive effects of modified chitosan medical anti-adhesion membrane on postoperative intra-abdominal adhesion]
PubMed ID: 23328428
Modified chitosan antiâadhesion membrane after colorectal surgery lowered adhesive ileus and sped bowel recoveryâimproved postâsurgical healing outcomes.
- A self-controlled comparative clinical trial to explore the effectiveness of three topical hemostatic agents for stopping severe epistaxis in pediatrics with inherited coagulopathies
PubMed ID: 24164872
Pediatric study: chitosanâreinforced nasal tampon stopped severe epistaxis faster/more reliably than comparatorsâclear hemostatic/wound benefit.
- Novel scaffold-based BST-CarGel treatment results in superior cartilage repair compared with microfracture in a randomized controlled trial
PubMed ID: 24048551
Chitosan scaffold for cartilage defects produced superior tissue repair vs microfractureâpromotes tissue regeneration relevant to surgical recovery.
- An open multicenter comparative randomized clinical study on chitosan
PubMed ID: 25845544
Randomized multicenter trial: chitosan wound dressing significantly sped healing, reduced pain and wound depth vs Vaseline gauzeâstrong clinical woundâhealing evidence.
- A comparison of 2 devices for radial artery hemostasis after transradial coronary intervention
PubMed ID: 24496325
Large RCT: chitosanâbased hemostatic pad reduced compression time and bleeding after radial accessârelevant to hemostasis and wound/vascular recovery.
- Hemostasis pad combined with compression device after transradial coronary procedures: A randomized controlled trial
PubMed ID: 28742134
Randomized human trial: addition of chitosan hemostatic pad to compression substantially shortened time to hemostasis after radial proceduresâsupports bleeding control in wound settings.
- Prospective randomized single-blind study of post-operative bleeding after minor oral surgery in patients with cirrhosis
PubMed ID: 30457557
Topical chitosan hemostatic agent controlled postâextraction bleeding in cirrhotic patients as safely as comparator â wound/bleeding control relevance.
- Efficacy of a chitosan tampon in the loop electrosurgical excision procedure: A prospective randomized controlled study
PubMed ID: 32265495
Chitosan tampon after LEEP reduced postoperative bleeding/discharge and improved cervical healing â surgical wound recovery benefit.
- Application of a collagen matrix dressing on a neuropathic diabetic foot ulcer: a randomised control trial
PubMed ID: 32160125
Collagen matrix dressing containing chitosan significantly accelerated diabetic foot ulcer size reduction and raised complete healing rates vs gauze.
- Randomized trial comparing radial hemostasis techniques; catechol conjugated chitosan pad (InnoSEAL) versus pneumatic compression band
PubMed ID: 33655650
Chitosanâbased radial hemostasis pad produced clinically meaningful shortening of hemostasis time after arterial access.
- Prospective, randomized, controlled, noninferiority clinical trial to evaluate the safety and efficacy of absorbable macroporous polysaccharide composites as adjunct to hemostasis during open surgery
PubMed ID: 35842821
Large RCT: chitosanâcontaining absorbable hemostatic composite was at least as effective and slightly faster at stopping surgical bleeding.
- Is Chitosan Dental Dressing Better Than Cotton Gauze in Achieving Hemostasis in Patients on Antithrombotics?
PubMed ID: 36403660
Chitosan dental dressing produced a large reduction in time to hemostasis and markedly better alveolar healing in antithrombotic patients.
- Clinical efficacy of wet dressing combined with chitosan wound dressing in the treatment of deep second-degree burn wounds: A prospective, randomised, single-blind, positive control clinical trial
PubMed ID: 35922093
Chitosan wound dressings for deep secondâdegree burns shortened healing time, dramatically reduced bacterial positivity and improved scar scores.
- Clinical efficacy of chitosan-based hydrocolloid dressing in the treatment of chronic refractory wounds
PubMed ID: 35524492
Chitosan hydrocolloid dressings sped healing, reduced pain and wound size in chronic hardâtoâheal wounds (randomized clinical trial).
- Comparison between two different local hemostatic methods for dental extractions in patients on dual antiplatelet therapy: a within-person, single-blind, randomized study
PubMed ID: 37689449
Chitosan HemCon dental dressing shortened intraâoral bleeding time and improved early healing in patients on antiplatelet therapy.
- The impact of hydroxybutyl chitosan and 5-fluorouracil on the procedure of endoscopic endonasal dacryocystorhinostomy
PubMed ID: 39257076
Thermosensitive hydroxybutyl chitosan used in endoscopic DCR increased anastomosis size and reduced early scarring/complicationsâimproved surgical healing outcomes.
- Ultrasound-guided Hydrogel Injection Provides Better Therapeutic Effects After Hand Tendon Surgery Than Intraoperative Injection: A Randomized Controlled Trial
PubMed ID: 38996334
Ultrasoundâguided postoperative injection of carboxymethyl chitosan hydrogel improved longâterm finger motion, reduced early pain and enhanced functional wound recovery after tendon repair.
- A randomized, placebo-controlled study of chitosan gel for the treatment of chronic diabetic foot ulcers (the CHITOWOUND study)
PubMed ID: 38909998
Topical chitosan gel accelerated healing and increased rates of large percent closure in diabetic foot ulcers (RCT).
Oral health (30)
- Efficacy of chitosan-based chewing gum on reducing salivary S. mutans counts and salivary pH: a randomised clinical trial
PubMed ID: 33138680
RDB gum trial reduced S. mutans counts and slightly raised salivary pH (antimicrobial oral benefit).
- Colloidal chitosan-silver nanoparticles-fluoride nanocomposite as an antibacterial mouthwash against salivary Streptococcus mutans in orthodontic patients (a randomized clinical trial)
PubMed ID: 39028340
Chitosan-stabilized Agâfluoride mouthwash reduced S. mutans in orthodontic patients, similar to CHX (repeated entry for emphasis).
- Efficacy and safety of a 0.05Â % nanoencapsulated imiquimod hydrogel for the treatment of actinic cheilitis: Drug release analysis and clinical study
PubMed ID: 39147219
Chitosan hydrogel enabled effective, better-tolerated imiquimod delivery for actinic cheilitis (lip/oral margin benefit).
- Hydroxyapatite-Fluoride Toothpastes on Caries Activity: A Triple-Blind Randomized Clinical Trial
PubMed ID: 39971658
Large RCT: hydroxyapatiteâfluoride toothpastes in a chitosan matrix improved enamel lesion inactivity and reduced biofilm acidogenicityâstrong clinical oralâhealth data (multi-component).
- Clinical and radiographic evaluation of melatonin and chitosan loaded nanoparticles in the treatment of periodontal intra-bony defects: A Randomized controlled clinical trial
PubMed ID: 40312586
Chitosan nanoparticles placed into periodontal defects improved probing depth/attachment and bone fill â strong oral/periodontal benefit.
- Efficacy of Continuous Chelation With Etidronate And Sequential Chelation With Chitosan On Bacterial Reduction In Teeth With Pulp Necrosis: A Double-Blind, Randomized Clinical Trial
PubMed ID: 41685847
Chitosan irrigation in root canals produced ~97% bacterial load reduction â substantial endodontic antimicrobial effect.
- Antibiofilm activity of chitosan nanoparticles incorporated into three-dimensional printed clear aligners on Streptococcus mutans after in vivo aging: A randomized clinical trial
PubMed ID: 41073253
Chitosan nanoparticles in aligners markedly reduced plaque, bleeding on probing and S. mutans counts â robust oral hygiene benefit.
- The anti-fungal effect of miconazole and miconazole-loaded chitosan nanoparticles gels in diabetic patients with Oral candidiasis-randomized control clinical trial and microbiological analysis
PubMed ID: 38321454
Miconazole in chitosan nanoparticle gel cleared oral Candida similarly with fewer local side effectsâeffective oral antifungal delivery.
- Application of Three Types of Scaffolds in Pulp Regeneration for Permanent Mature Teeth with Periapical Lesions: A Randomized Controlled Trial
PubMed ID: 39704629
Enzymatically modified chitosan improved pulpâregeneration outcomes and return of sensibility versus controlsâdirect dental regenerative benefit.
- Comparison between two different local hemostatic methods for dental extractions in patients on dual antiplatelet therapy: a within-person, single-blind, randomized study
PubMed ID: 37689449
Chitosan HemCon dressing shortened intraoral bleeding time after extractions and improved early healing in anticoagulated patientsâuseful oral-hemostatic/wound benefit.
- Suppression of subgingival bacteria by antimicrobial photodynamic therapy using transgingival irradiation: A randomized clinical trial
PubMed ID: 37910482
Chitosan-coated photosensitizer nanoparticles plus aPDT sharply reduced subgingival bacteria in a randomized clinical trialâstrong periodontal adjunct evidence.
- Effect of lactobacillus reuteri-derived probiotic nano-formulation on recurrent aphthous stomatitis: a double-blinded randomized clinical trial
PubMed ID: 38114936
Lactobacillus reuteri delivered in a chitosan nanogel healed recurrent mouth ulcers fasterâwith benefit but confounded by probiotic activity.
- Non-surgical treatment of mild to moderate peri-implantitis with an oscillating chitosan brush or a titanium curette-12-month follow-up of a multicenter randomized clinical trial
PubMed ID: 37139538
Oscillating chitosan brush produced similar improvements in periâimplant inflammation/pocket depth as standard curettesâpractical oral-care benefit.
- Er:YAG laser in selective caries removal and dentin treatment with chitosan: a randomized clinical trial in primary molars
PubMed ID: 37697177
Topical chitosan on dentin reduced Streptococcus mutans counts in primary molars, indicating antibacterial oral benefit.
- Efficacy of HAF toothpastes in primary and permanent dentitions. A 2-years triple-blind RCT
PubMed ID: 35139410
Large 2âyear RCT: toothpaste with hydroxyapatite in a chitosan matrix reduced new/progressing caries vs fluoride paste â strong oral health outcome.
- Is Chitosan Dental Dressing Better Than Cotton Gauze in Achieving Hemostasis in Patients on Antithrombotics?
PubMed ID: 36403660
Dental chitosan dressing in antithrombotic patients markedly shortened time to hemostasis and improved alveolar healing â strong oral procedural benefit.
- Treatment of residual pockets using an oscillating chitosan device versus regular curettes alone-A randomized, feasibility parallel-arm clinical trial
PubMed ID: 34710240
Multicenter RCT: chitosan oscillating brush produced superior pocketâdepth reductions and composite periodontal outcomes vs curettes.
- Supportive treatment following peri-implantitis surgery: An RCT using titanium curettes or chitosan brushes
PubMed ID: 32767565
Maintenance trial found chitosan brushes produced similar clinical outcomes to curettes after periâimplantitis surgery (no advantage).
- Clinical evaluation of an oral mucoadhesive film containing chitosan for the treatment of recurrent aphthous stomatitis: a randomized, double-blind study
PubMed ID: 31179773
Oral mucoadhesive chitosan film accelerated healing of recurrent aphthous ulcers â clinically meaningful oral mucosal healing.
- In vivo study of antifungal effects of low-molecular-weight chitosan against Candida albicans
PubMed ID: 28904319
Randomized clinical trial in denture stomatitis: chitosan mouthwash reduced erythema, symptoms and Candida counts comparable to standard antifungalâstrong direct oral health evidence.
- Chewing chitosan-containing gum effectively inhibits the growth of cariogenic bacteria
PubMed ID: 17112460
Chitosan chewing gum greatly lowered mouth bacteria, especially mutans streptococci, with effects lasting at least an hour (strong clinical result).
- Clinical evaluation of the remineralizing potential of biomimetic scaffolds on enamel white spot lesions: A 12-month randomized controlled trial
PubMed ID: 41412271
Phosphorylated nano-chitosan scaffold produced strong, sustained remineralization of early enamel lesions over 12 months (high-quality RCT).
- Metals, fluoride and bioactive glass on dentin hypersensitivity and quality of life: A 6-month double-blind randomized clinical trial
PubMed ID: 40550352
RCT including a chitosanâcontaining toothpaste showed dentin hypersensitivity reduction and improved oral QoL (productâlevel evidence of oral benefit).
- Efficacy of using chitosan and chitosan nanoparticles as final irrigating solutions on smear layer removal and mineral content of intraradicular dentin
PubMed ID: 37635477
Ex vivo study: chitosan (nano) removed smear layer reasonably and better preserved dentin mineral content than EDTA â endodontic procedural relevance to oral health.
- A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 37668810
See above â strong RCT evidence for treating oral mucositis (duplication retained for clarity).
- Effects of Hydroxyapatite-Containing Toothpastes on Some Caries-Related Variables: A Randomised Clinical Trial
PubMed ID: 38453554
Toothpaste containing hydroxyapatite in a chitosan matrix reduced mutans counts, raised plaque pH and lowered new enamel lesions versus standard fluorideâstrong cariology signal (multiâingredient formula).
- Effectiveness of an Alcohol-Free Chitosan-Curcuminoid Mouthwash Compared with Chlorhexidine Mouthwash in Denture Stomatitis Treatment: A Randomized Trial
PubMed ID: 30758216
RDB trial: chitosanâcurcuminoid mouthwash led to higher resolution of denture stomatitis than chlorhexidine (antifungal oral health benefit).
- The efficacy of a novel chitosan gel on hemostasis and wound healing after endoscopic sinus surgery
PubMed ID: 20109331
Chitosan/dextran gel in ESS produced rapid hemostasis and fewer adhesions (ENT/sinonasal surgical setting with oral/upper airway relevance).
- Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
PubMed ID: 32683390
Splitâmouth RCT: chitosanâcontaining topical gel produced major reductions in pain, swelling and dramatically improved wound healing after extraction (strong clinical oral benefit).
- Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery
PubMed ID: 26471464
Crossover human trial: chitosanâcontaining gel (with other actives) reduced postâextraction pain/inflammation and improved cicatrization (oral wound/health outcome).
Inflammation (13)
- A Chitosan-Coated Chamomile Microparticles Formulation to Prevent Radiodermatitis in Breast: A Double-blinded, Controlled, Randomized, Phase II Clinical Trial
PubMed ID: 35393979
Topical chitosan-coated chamomile reduced moderate/severe radiation dermatitis and delayed time to higher-grade inflammation.
- A comparison of effectiveness between Posisep and Merocel nasal packing after endoscopic sinus surgery: Findings from a randomized, double-blinded, controlled trial
PubMed ID: 37565850
Chitosanâbased nasal packing produced better early symptom relief and improved endoscopic healing after sinus surgery (reduced postoperative inflammation/symptom burden).
- A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 37668810
Chitosanâbased doxepin nanogel accelerated reductions in mucositis severity and pain (reduced mucosal inflammation in chemotherapy patients).
- Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
PubMed ID: 32683390
Topical chitosanâcontaining gel reduced postoperative pain and swelling and greatly improved wound healing in an RCT (antiâinflammatory/repair effect in humans).
- Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery
PubMed ID: 26471464
Crossover RCT: chitosanâcontaining gel decreased pain and facial inflammation after extractions vs control (clinical antiâinflammatory effect).
- Emulsion containing a chitosan derivative in children with mild atopic dermatitis: A randomized controlled trial
PubMed ID: 40172178
PMCMC emulsion reduced eczema severity, implying antiâinflammatory/immunomodulatory action in skin.
- Clinical efficacy of wet dressing combined with chitosan wound dressing in the treatment of deep second-degree burn wounds: A prospective, randomised, single-blind, positive control clinical trial
PubMed ID: 35922093
Burn trial showed reduced bacterial positivity and better scarringâconsistent with improved inflammatory control at the wound site.
- Effect of a Thermosensitive Hydroxybutyl Chitosan Hydrogel on Postoperative Sequalae and Quality of Life After Impacted Mandibular Third Molar Extraction
PubMed ID: 38971179
Hydroxybutyl chitosan reduced post-extraction pain and swellingâevidence of antiâinflammatory/local modulatory effect.
- Treatment of residual pockets using an oscillating chitosan device versus regular curettes alone-A randomized, feasibility parallel-arm clinical trial
PubMed ID: 34710240
Chitosan brush produced greater pocketâdepth reductions and composite periodontal improvement, reflecting reduced local inflammation.
- A randomised controlled trial on the effectiveness of an advanced wound dressing used in Iran
PubMed ID: 18705234
Chitosan-containing dressing reduced infections and improved healingâactions that reflect modulation of local inflammatory/infective processes in wounds.
- An open multicenter comparative randomized clinical study on chitosan
PubMed ID: 25845544
Chitosan wound dressing decreased pain and wound depth in an RCT, consistent with reduced local inflammation and faster recovery.
- Clinical and instrumental assessment of the effects of a new product based on hydroxypropyl chitosan and potassium azeloyl diglycinate in the management of rosacea
PubMed ID: 22360333
Rosacea trial showed reductions in erythema and symptomsâclinically relevant local antiâinflammatory/skinâcalming effects.
- The Effect of Modified Chitosan Medical Membrane on the Inflammation and Recurrence After Primary Pterygium Excision: A Prospective Randomized Clinical Study
PubMed ID: 41314274
Local decreases in ILâ8 and TNFâÎą in tears after chitosan membrane indicate a meaningful antiâinflammatory effect at the ocular surface.
Skin health (11)
- A randomized, placebo-controlled study of chitosan gel for the treatment of chronic diabetic foot ulcers (the CHITOWOUND study)
PubMed ID: 38909998
Topical chitosan gel accelerated healing of chronic diabetic foot ulcersâclear local skin/wound benefit.
- Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery
PubMed ID: 26471464
Postâmolar extraction gel containing chitosan reduced pain/swelling and aided cicatrization versus bicarbonate rinse (topical healing benefit).
- Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
PubMed ID: 32683390
Topical gel (with chitosan) applied to extraction sites markedly improved wound healing and reduced pain/swelling in humans (topical repair effect relevant to skin/wound healing).
- Efficacy and safety of the combination of isosorbide dinitrate spray and chitosan gel for the treatment of diabetic foot ulcers: A double-blind, randomized, clinical trial
PubMed ID: 29682995
Randomized trial in diabetic foot ulcers: topical chitosan (alone or combined) improved wound closure metrics vs placebo (direct skin wound healing benefit).
- A Chitosan-Coated Chamomile Microparticles Formulation to Prevent Radiodermatitis in Breast: A Double-blinded, Controlled, Randomized, Phase II Clinical Trial
PubMed ID: 35393979
Topical chitosanâcoated chamomile reduced moderate-or-worse radiation dermatitis and improved skin recovery, a clear topical skin benefit.
- A randomised controlled trial on the effectiveness of an advanced wound dressing used in Iran
PubMed ID: 18705234
Chitosan-containing moist dressing greatly increased chronic wound healing and prevented infections, directly relevant to skin repair.
- Clinical and instrumental assessment of the effects of a new product based on hydroxypropyl chitosan and potassium azeloyl diglycinate in the management of rosacea
PubMed ID: 22360333
Randomized DB study: hydroxypropyl chitosan cream reduced rosacea erythema and improved hydrationâclinically meaningful skin benefits.
- Application of a collagen matrix dressing on a neuropathic diabetic foot ulcer: a randomised control trial
PubMed ID: 32160125
Chitosan/collagen matrix improved healing rates of neuropathic diabetic foot ulcers â relevant to skin repair.
- Clinical efficacy of wet dressing combined with chitosan wound dressing in the treatment of deep second-degree burn wounds: A prospective, randomised, single-blind, positive control clinical trial
PubMed ID: 35922093
Chitosan dressings accelerated healing of deep secondâdegree burns, reduced infection and improved scar scoresâstrong therapeutic skin benefit.
- Efficacy and safety of a 0.05Â % nanoencapsulated imiquimod hydrogel for the treatment of actinic cheilitis: Drug release analysis and clinical study
PubMed ID: 39147219
Nanoencapsulated imiquimod in chitosan hydrogel treated actinic cheilitis effectively with better tolerabilityâchitosan as a dermatologic delivery vehicle.
- Emulsion containing a chitosan derivative in children with mild atopic dermatitis: A randomized controlled trial
PubMed ID: 40172178
PMCMC (chitosan derivative) emulsion improved eczema severity and caregiver QoL in childrenâdirect beneficial skin effect.
Weight management (8)
- Effect of a polysaccharide-rich hydrolysate from Saccharomyces cerevisiae (LipiGoÂŽ) in body weight loss: randomised, double-blind, placebo-controlled clinical trial in overweight and obese adults
PubMed ID: 28251654
Doubleâblind RCT of chitin/chitosan supplement: small weight decrease and reductions in waist/body fat vs baseline but effects were modest and not robust across endpoints.
- The effects of chitosan supplementation on anthropometric indicators of obesity, lipid and glycemic profiles, and appetite-regulated hormones in adolescents with overweight or obesity: a randomized, double-blind clinical trial
PubMed ID: 36064382
12âweek RCT in adolescents (3 g/day) produced substantial and clinically meaningful weight, BMI and waist reductions versus placebo.
- The effect of chitosan supplementation on liver function, hepatic steatosis predictors, and metabolic indicators in adults with non-alcoholic fatty liver disease: a randomized, double-blinded, placebo-controlled, clinical trial
PubMed ID: 40025618
NAFLD RCT: 1.5 g/day chitosan for 8 weeks produced modest weight and waist reductions (secondary, modest effect in clinical population on diet).
- Regular Consumption of Lipigo(ÂŽ) Promotes the Reduction of Body Weight and Improves the Rebound Effect of Obese People Undergo a Comprehensive Weight Loss Program
PubMed ID: 32630079
Large RCT of a chitinâchitosan containing fiber supplement showed greater weight loss and reduced regain in obese class I subgroup (benefit but combined product and subgroupâspecific).
- [Effect of chitosan in complex management of obesity]
PubMed ID: 12420344
In a structured diet/exercise/behavior program, chitosan produced ~5 kg greater weight loss over 6 months versus placebo (meaningful adjunctive effect).
- Evaluating efficacy of a chitosan product using a double-blinded, placebo-controlled protocol
PubMed ID: 17031007
Randomized doubleâblind human trial: daily chitosan capsules produced modest but statistically significant weight and fatâmass loss vs placebo (direct RCT evidence).
- L-ascorbic acid addition to chitosan reduces body weight in overweight women
PubMed ID: 25835230
Randomized study in overweight women: chitosan (with and without vitamin C) produced modest weight and BMI reductions over 8 weeks (chitosanâvitC > chitosan), supporting shortâterm weight effect.
- Single-blind, placebo controlled randomised clinical study of chitosan for body weight reduction
PubMed ID: 26747458
Randomized trial (90 days): fungalâderived chitosan capsules produced a modest but significant weight, BMI and bodyâfat reduction (~â2.8 kg vs placebo), supporting weightâmanagement effect.
Digestive support (5)
- [Preventive effects of modified chitosan medical anti-adhesion membrane on postoperative intra-abdominal adhesion]
PubMed ID: 23328428
Postâcolorectal surgery chitosan membrane shortened time to gut movement and reduced adhesive ileusâclinically meaningful digestive recovery improvement.
- [Adhesion prevention after Cesarean section by short-term biological barrier of modified chitosan]
PubMed ID: 24767299
Large randomized trial of modified chitosan used during Cesarean reduced time to first flatus, postoperative infections and pelvic adhesionsâsupports postoperative digestive recovery.
- Norovirus vaccine against experimental human Norwalk Virus illness
PubMed ID: 22150036
Norwalk VLP vaccine with chitosan reduced gastroenteritis incidence, infection and disease severity in a human challengeâdirect digestive health benefit.
- Effect of dietary oligochitosan supplementation on ileal digestibility of nutrients and performance in broilers
PubMed ID: 16206559
Broiler chicken study: chitosan oligosaccharide increased ileal nutrient digestibility and feed efficiency (animal evidence of digestive effects).
- The Effect of Chitosan Supplementation on the Gut Microbiota and Various Health Factors in Icelandic Females: A Placebo-Controlled, Double-Blind, Randomized Trial
PubMed ID: 40484808
Oral chitosan altered gut microbiota over 12 weeks â supports an effect on digestive tract ecosystem/function.
Heart health (6)
- Efficacy and safety of chitosan HEP-40 in the management of hypercholesterolemia: a randomized, multicenter, placebo-controlled trial
PubMed ID: 18072822
LowâMW chitosan (HEPâ40) produced doseâdependent LDL reductions up to ~17% over 12 weeks, relevant to cardiovascular risk.
- Double-blind, randomized, crossover, controlled clinical trial of NaCl + Chitosan 3% versus NaCl on mild or moderate high blood pressure during the diet and lifestyle improvement period before possible prescription of an antihypertensive treatment
PubMed ID: 23435397
Doubleâblind human trial: chitosan-containing salt produced substantially greater systolic/diastolic BP reductionsâdirect cardiovascular benefit.
- A comparison of 2 devices for radial artery hemostasis after transradial coronary intervention
PubMed ID: 24496325
Large RCT: chitosan hemostatic pad after radial access reduced bleeding/compression time and lowered radial artery occlusion ratesâimproves vascular procedural outcomes.
- Effect of NaCl + Chitosan 3% vs. NaCl on high blood pressure parameters of healthy volunteers with prehypertension
PubMed ID: 28862406
Randomized doubleâblind human trial: chitosanâcontaining salt produced a clinically meaningful SBP reduction vs NaCl, directly supporting cardiovascular risk reduction.
- Influence of Chitosan Treatment on Surrogate Serum Markers of Cholesterol Metabolism in Obese Subjects
PubMed ID: 29324705
Randomized trial in overweight adults: chitosan (3 g/day) produced modest but statistically significant LDL and total cholesterol reductionsârelevant to heart health.
- Efficacy of Food Industry By-Product β-Glucan/Chitin-Chitosan on Lipid Profile of Overweight and Obese Individuals: Sustainability and Nutraceuticals
PubMed ID: 39408385
Randomized doubleâblind trial showing increased HDL and reduced ApoB (and LDL in highâLDL subgroup) with a βâglucan/chitinâchitosan product (direct lipid/CV risk marker benefit).
Immune support (7)
- Effectiveness of an Alcohol-Free Chitosan-Curcuminoid Mouthwash Compared with Chlorhexidine Mouthwash in Denture Stomatitis Treatment: A Randomized Trial
PubMed ID: 30758216
Randomized human trial showing chitosanâcurcuminoid mouthwash cleared Candida lesions (direct antimicrobial/immuneârelevant effect).
- Efficacy of chitosan-based chewing gum on reducing salivary S. mutans counts and salivary pH: a randomised clinical trial
PubMed ID: 33138680
RDB human gum trial reduced salivary S. mutans (antimicrobial effect relevant to oral immune defense).
- Induction of protective serum meningococcal bactericidal and diphtheria-neutralizing antibodies and mucosal immunoglobulin A in volunteers by nasal insufflations of the Neisseria meningitidis serogroup C polysaccharide-CRM197 conjugate vaccine mixed with chitosan
PubMed ID: 16299322
Chitosan used as a nasal adjuvant produced strong systemic and mucosal antibody responses and bactericidal titers.
- Evaluation of safety and efficacy as an adjuvant for the chitosan-based vaccine delivery vehicle ViscoGel in a single-blind randomised Phase I/IIa clinical trial
PubMed ID: 25218298
Large human trial: chitosan hydrogel was safe and increased IFN-Îł cellular responses though not antibody titers.
- Norovirus vaccine against experimental human Norwalk Virus illness
PubMed ID: 22150036
Human intranasal Norwalk vaccine with chitosan markedly reduced infection and diseaseâstrong clinical immune protection.
- Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study
PubMed ID: 27159166
Human phaseâ1 trial: chitosan used as adjuvant with gp140 induced systemic and some mucosal IgG and CD4 Tâcell responses, supporting immunostimulatory/adjuvant activity.
- Clinical efficacy of wet dressing combined with chitosan wound dressing in the treatment of deep second-degree burn wounds: A prospective, randomised, single-blind, positive control clinical trial
PubMed ID: 35922093
Chitosan dressings reduced wound infection rates in burns, indicating antimicrobial/indirect immuneâsupporting effects.
Cholesterol (4)
- Efficacy and safety of chitosan HEP-40 in the management of hypercholesterolemia: a randomized, multicenter, placebo-controlled trial
PubMed ID: 18072822
Randomized multicenter trial: dose-dependent LDL reductions up to â17% at highest lowâMW chitosan doseârobust lipidâlowering evidence.
- Influence of Chitosan Treatment on Surrogate Serum Markers of Cholesterol Metabolism in Obese Subjects
PubMed ID: 29324705
Wellâcontrolled randomized human trial in overweight adults: 3 g/day chitosan for 12 weeks produced modest but statistically significant LDL and total cholesterol reductions vs placebo.
- Efficacy of Food Industry By-Product β-Glucan/Chitin-Chitosan on Lipid Profile of Overweight and Obese Individuals: Sustainability and Nutraceuticals
PubMed ID: 39408385
RDB trial with yeast βâglucan/chitinâchitosan product produced HDL increases and ApoB decreases (solid lipid marker improvements; chitosan component present).
- Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial
PubMed ID: 12771974
Oral chitosan produced small but statistically significant reductions in total cholesterol (and LDL in older subgroup) over 56 days.
Nutrient uptake (3)
- Analgesic efficacy and safety of morphine-chitosan nasal solution in patients with moderate to severe pain following orthopedic surgery
PubMed ID: 18254761
Dose-related intranasal morphine analgesia using chitosan formulation shows clinically meaningful mucosal absorption enhancement.
- The analgesic efficacy and safety of a novel intranasal morphine formulation (morphine plus chitosan), immediate release oral morphine, intravenous morphine, and placebo in a postsurgical dental pain model
PubMed ID: 19020153
Intranasal morphine with chitosan enabled systemic analgesic levels comparable to IV dosingâchitosan acting as absorption enhancer.
- Pharmacodynamic studies of nasal tetracosactide with salivary glucocorticoids for a noninvasive Short Synacthen Test
PubMed ID: 32593173
Mucoadhesive chitosan formulation markedly increased nasal absorption/bioavailability of tetracosactide (pharmacologic proof of absorption enhancement).
Bowel regularity (3)
- Norovirus vaccine against experimental human Norwalk Virus illness
PubMed ID: 22150036
Reduced Norwalk gastroenteritis and infection indirectly supports maintenance of regular gut function by preventing acute diarrheal disease.
- [Preventive effects of modified chitosan medical anti-adhesion membrane on postoperative intra-abdominal adhesion]
PubMed ID: 23328428
After colorectal surgery, chitosan membrane shortened time to first gut movement (~â0.9 days)âdirect effect on early postoperative bowel function.
- [Adhesion prevention after Cesarean section by short-term biological barrier of modified chitosan]
PubMed ID: 24767299
Cesarean RCT: use of modified chitosan during surgery shortened time to first flatus by ~9 hoursâevidence of accelerated return of bowel function.
Appetite suppression (3)
- Evaluating efficacy of a chitosan product using a double-blinded, placebo-controlled protocol
PubMed ID: 17031007
RCT showing modest weight and fatâmass loss with chitosan supplementation; appetite control could be a plausible mechanism though not directly measured.
- Regular Consumption of Lipigo(ÂŽ) Promotes the Reduction of Body Weight and Improves the Rebound Effect of Obese People Undergo a Comprehensive Weight Loss Program
PubMed ID: 32630079
Fiber/chitinâchitosan supplement improved weight loss and reduced regain in obese class I subgroup â satiety/appetite effects plausible but not directly measured.
- The effects of chitosan supplementation on anthropometric indicators of obesity, lipid and glycemic profiles, and appetite-regulated hormones in adolescents with overweight or obesity: a randomized, double-blind clinical trial
PubMed ID: 36064382
12âweek adolescent RCT (3 g/day) improved insulin, adiponectin and leptin and reported appetiteâhormone changes consistent with appetite modulation.
Satiety (3)
- Regular Consumption of Lipigo(ÂŽ) Promotes the Reduction of Body Weight and Improves the Rebound Effect of Obese People Undergo a Comprehensive Weight Loss Program
PubMed ID: 32630079
Chitinâchitosan fiber supplement associated with greater weight loss and less regain in Obesity I subgroupâsatiety effects plausible but not directly reported.
- Evaluating efficacy of a chitosan product using a double-blinded, placebo-controlled protocol
PubMed ID: 17031007
Weightâloss RCT with chitosan (modest bodyfat reduction) â satiety may be a contributing mechanism though not directly measured.
- The effects of chitosan supplementation on anthropometric indicators of obesity, lipid and glycemic profiles, and appetite-regulated hormones in adolescents with overweight or obesity: a randomized, double-blind clinical trial
PubMed ID: 36064382
Adolescent RCT showed substantial weight loss and favorable changes in appetiteârelated hormones (leptin/adiponectin/insulin), supporting satiety/appetite effects.
Joint comfort (3)
- Ultrasound-guided Hydrogel Injection Provides Better Therapeutic Effects After Hand Tendon Surgery Than Intraoperative Injection: A Randomized Controlled Trial
PubMed ID: 38996334
Carboxymethyl chitosan hydrogel injections after tendon repair improved longâterm motion and reduced painâfunctional benefit around joints/tendons.
- Course-based intra-articular injection of medical chitosan mitigates excessive deposition of triacylglycerides in the synovial tissue of the knee osteoarthritis
PubMed ID: 38984546
Intraâarticular chitosan injections in knee OA reduced synovial TAG deposition and prolonged time before arthroplastyâclinical jointâsparing signal.
- Novel scaffold-based BST-CarGel treatment results in superior cartilage repair compared with microfracture in a randomized controlled trial
PubMed ID: 24048551
Multicenter RCT: chitosanâbased scaffold improved cartilage lesion filling and produced more hyalineâlike repair vs microfractureâdirect joint tissue benefit.
Blood sugar (2)
- Chitosan oligosaccharide (GO2KA1) improves postprandial glycemic response in subjects with impaired glucose tolerance and impaired fasting glucose and in healthy subjects: a crossover, randomized controlled trial
PubMed ID: 31685797
Crossover RCT: lowâMW chitosan oligosaccharide capsule modestly lowered 60âmin postâsucrose glucose and overall postprandial glucose AUC vs placebo.
- The effects of chitosan supplementation on anthropometric indicators of obesity, lipid and glycemic profiles, and appetite-regulated hormones in adolescents with overweight or obesity: a randomized, double-blind clinical trial
PubMed ID: 36064382
12âweek RCT in overweight adolescents improved insulin and related hormones along with weight loss â meaningful support for glucose/insulin balance.
Gut health (2)
- The Effect of Chitosan Supplementation on the Gut Microbiota and Various Health Factors in Icelandic Females: A Placebo-Controlled, Double-Blind, Randomized Trial
PubMed ID: 40484808
12âweek oral chitosan changed gut microbiome composition (diversity/evenness and Actinobacteriota) â direct microbiome effect.
- Effectiveness of an Alcohol-Free Chitosan-Curcuminoid Mouthwash Compared with Chlorhexidine Mouthwash in Denture Stomatitis Treatment: A Randomized Trial
PubMed ID: 30758216
Chitosanâcurcuminoid mouthwash reduced Candida and improved stomatitis â demonstrates topical microbial modulation in the oral microbiome (not gut but oral microbiota).
Bone health (1)
- Clinical and radiographic evaluation of melatonin and chitosan loaded nanoparticles in the treatment of periodontal intra-bony defects: A Randomized controlled clinical trial
PubMed ID: 40312586
Chitosan nanoparticles in periodontal defects produced measurable boneâfill improvement â direct bone healing effect in alveolus/periodontium.
Healthy aging (1)
- Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial
PubMed ID: 31344296
RDB trial: chitosanâbased nail lacquer improved brittle nails (appearance/function outcome relevant to aging/dermatologic aging).
Similar by evidence
Supplements the same benefits carry qualifying findings for â a fact about the evidence graph, not a recommendation to swap.
Products with Chitosan
Search all67 products whose verified label declares Chitosan â not every bottle that mentions it in a title.