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Betaine

16 benefits mapped to clinical evidence across supplements.

Dose per serving from products

2,380 products in our catalogue print how much Betaine a serving holds.

Most common: 1 g to 2.5 g, 40% of 2,380 products.

Dose per servingProducts
10 mg or less
73
10 mg to 25 mg
90
25 mg to 50 mg
139
50 mg to 100 mg
143
100 mg to 250 mg
416
250 mg to 500 mg
251
500 mg to 1 g
255
1 g to 2.5 g
955
over 2.5 g
58

Dose per serving from research

37 study groups in 28 studies say how much Betaine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 g to 5 g, 30% of 37 study groups.

Daily doseStudy groups
500 mg or less
2
500 mg to 1 g
3
1 g to 2.5 g
10
2.5 g to 5 g
11
5 g to 10 g
10
over 10 g
1

See every study group

Commonly used together

14 of 39 study groups took Betaine with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Folic Acid
10
Vitamin B12
4
Vitamin B6
3

Benefit Evidence

LDL-C ↑; betaine varies

Homocysteine ↓; betaine ↑

6,853 people

Betaine↑, Hcy↓

Betaine ↔ glucose

5,480 people

Betaine lowers Hcy

Betaine boosts methylation

2,667 people
Heart health
Moderate

Homocysteine −24%

CVD risk HR≈2.2

2,476 people
Brain health
Moderate

Methylation/cognition: −36% Hcy

Choline/betaine brain support

1,265 people
Cell health
Moderate

Homocysteine ↓ 10–24%

Betaine/choline ↑, Hcy ↓

B12/IGF-1 ↑

1,085 people

BMI/body fat ↓

Fat loss markers ↓

Liver enzymes ↓

1,119 people

Lower homocysteine 36%

Better memory, betaïne

Oxidative stress down

585 people

Inflammation↓ 40%

Healing/bacteria↓

Performance↑

579 people

Strength, lean mass +5.9%

Anabolic signaling, hormones

110 people

Strength/hypertrophy ↑

Endurance/performance ↑

110 people

Fat loss, lower enzymes

CAP/TE ↓, BMI ↓

753 people

BMI/body fat ↓

Lean mass ↑

362 people

Saliva flow, dryness −

Choline, fat absorption +

Gastric acid/absorption +

150 people
Acne
Weak

Less irritation, no acne change

AE −4.2 pp, no acne

81 people

Better mood/focus

+focus, no gains

80 people

Research sources

Cholesterol (19)
  1. Consumption of wheat aleurone-rich foods increases fasting plasma betaine and modestly decreases fasting homocysteine and LDL-cholesterol in adults

    PubMed ID: 20980654

    Dietary aleurone raised plasma betaine and modestly lowered homocysteine and LDL — favorable blood-marker changes.

  2. Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations

    PubMed ID: 15941890

    Large folic acid trial increased plasma betaine and confirmed inverse relation with homocysteine — supports betaine's beneficial blood marker effects.

  3. The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people

    PubMed ID: 17537289

    B12+folic acid markedly decreased tHcy and increased betaine; changes clustered with borderline cognitive signal — good evidence for blood marker modulation.

  4. Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women

    PubMed ID: 22172554

    Choline supplementation increased plasma betaine and produced a modest (borderline) reduction in total homocysteine — clear biomarker changes.

  5. Plasma trimethylamine-N-oxide following supplementation with vitamin D or D plus B vitamins

    PubMed ID: 27569255

    Randomized addition of B vitamins increased plasma betaine and lowered homocysteine and TMAO relative to control — intervention improved multiple blood markers.

  6. Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis: A Randomized Placebo-Controlled Trial

    PubMed ID: 26465792

    Choline-rich structured lipid in CF improved fat absorption (higher CFA) and related biomarkers — direct evidence of improved fat handling.

  7. Supplementation with Folic Acid, but Not Creatine, Increases Plasma Betaine, Decreases Plasma Dimethylglycine, and Prevents a Decrease in Plasma Choline in Arsenic-Exposed Bangladeshi Adults

    PubMed ID: 27052531

    Large RCT in arsenic-exposed adults: folic acid raised betaine and lowered DMG, preventing choline decline — robust changes in blood one‑carbon markers.

  8. Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine

    PubMed ID: 26771632

    Controlled study: betaine supplementation increased DMG and affected homocysteine during alcohol exposure — direct effects on blood metabolites.

  9. Plasma Metabolites From Choline Pathway and Risk of Cardiovascular Disease in the PREDIMED (Prevention With Mediterranean Diet) Study

    PubMed ID: 29080862

    Prospective cohort: choline-pathway metabolite levels predicted CVD events; betaine/choline ratio inversely associated with risk — blood marker predictive value.

  10. Nutritional supplementation alters associations between one-carbon metabolites and cardiometabolic risk profiles in older adults: a secondary analysis of the Vienna Active Ageing Study

    PubMed ID: 34240265

    Associations between DMG/betaine and LDL observed in elderly subjects in a multi‑intervention context; suggests links to blood lipid markers though not definitive.

  11. Use of a Micronutrient Cocktail to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Adults with Obesity: A Randomized, Double-Blinded Pilot Clinical Trial

    PubMed ID: 39202647

    Supplement cocktail including betaine reduced hepatic steatosis and fibrosis metrics (improved handling of fat in the liver; multi‑ingredient trial).

  12. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure

    PubMed ID: 11849459

    Glycine betaine reduced post‑methionine load homocysteine (~18%) in chronic renal failure — moderate evidence for blood‑marker improvement.

  13. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects

    PubMed ID: 12399266

    12‑week RCT in obese subjects: 6 g/day betaine modestly lowered plasma homocysteine (positive) but raised LDL/total cholesterol (adverse) — mixed effects on blood markers.

  14. Assessment of urinary betaine as a marker of diabetes mellitus in cardiovascular patients

    PubMed ID: 23936331

    High urinary betaine strongly correlated with HbA1c and diabetes risk in cardiovascular patients — strong association with clinical blood markers of glycemia.

  15. Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program

    PubMed ID: 26861782

    DPP metabolite study: higher baseline/increased betaine associated with lower incident diabetes (metabolic blood‑marker/clinical risk relevance).

  16. Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial

    PubMed ID: 27655522

    Randomized multicenter comparison: a betaine‑containing nutraceutical reduced plasma homocysteine substantially more than high‑dose folic acid (strong biochemical effect).

  17. A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia

    PubMed ID: 31408467

    Large RCT: betaine‑containing drink produced a substantial ~24% geometric mean homocysteine reduction vs control — strong biomarker improvement.

  18. Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial

    PubMed ID: 36717385

    Large RCT: B‑vitamins + 1 g betaine lowered homocysteine by ≈10% in high‑homocysteine adults and raised plasma betaine.

  19. Integrated analysis of the association between methionine cycle and risk of moyamoya disease

    PubMed ID: 37183324

    Observed lower betaine and higher homocysteine in patients — direct association with blood one‑carbon marker (clear observational finding).

Metabolism (12)
  1. Metabolite Biomarkers Linking a High-Fiber Rye Intervention with Cardiometabolic Risk Factors: The RyeWeight Study

    PubMed ID: 40838659

    Rye feeding increased betainized metabolites that correlated with weight/fat‑loss markers and metabolic improvements (dietary intervention correlations).

  2. Diets rich in whole grains increase betainized compounds associated with glucose metabolism

    PubMed ID: 30256894

    Whole‑grain interventions increased several betainized plasma compounds that inversely correlated with postprandial glucose/insulin (controlled dietary intervention evidence).

  3. Nutritional supplementation alters associations between one-carbon metabolites and cardiometabolic risk profiles in older adults: a secondary analysis of the Vienna Active Ageing Study

    PubMed ID: 34240265

    Correlations between betaine/DMG and cardiometabolic markers in elderly participants indicate metabolic ties, though confounded by multi‑nutrient/exercise interventions.

  4. Supplementation with Folic Acid, but Not Creatine, Increases Plasma Betaine, Decreases Plasma Dimethylglycine, and Prevents a Decrease in Plasma Choline in Arsenic-Exposed Bangladeshi Adults

    PubMed ID: 27052531

    Large randomized trial: folic acid supplementation increased plasma betaine and altered DMG and choline — clear intervention effects on one‑carbon metabolites.

  5. Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations

    PubMed ID: 15941890

    Folic acid supplementation raised plasma betaine (~15%) and showed inverse betaine–homocysteine associations — supports betaine's metabolic role.

  6. Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation

    PubMed ID: 14699020

    Human data showing plasma betaine predicts attenuated homocysteine response to methionine — direct evidence of betaine's role in one‑carbon metabolic balance.

  7. Metabolomic Profiles Associated With Blood Pressure Reduction in Response to the DASH and DASH-Sodium Dietary Interventions

    PubMed ID: 37161796

    DASH diet metabolites including betaine‑related molecules linked to blood pressure reductions and broader cardiometabolic changes (controlled feeding trial evidence).

  8. Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program

    PubMed ID: 26861782

    DPP analysis: baseline/increased betaine associated with substantially lower diabetes incidence and lifestyle intervention raised betaine—strong human metabolic association.

  9. Trimethylamine-N-oxide and its biological variations in vegetarians

    PubMed ID: 27562778

    Vegetarian cohort measured stable plasma betaine over time and TMAO/choline metabolites—evidence about betaine as a steady metabolic biomarker.

  10. Assessment of urinary betaine as a marker of diabetes mellitus in cardiovascular patients

    PubMed ID: 23936331

    Large cohort: high urinary betaine strongly associated with prevalent/incident diabetes and tracked with HbA1c — major metabolic signal linking betaine metabolism to glycemic dysregulation.

  11. Consumption of wheat aleurone-rich foods increases fasting plasma betaine and modestly decreases fasting homocysteine and LDL-cholesterol in adults

    PubMed ID: 20980654

    Aleurone (high-betain) intake raised plasma betaine and modestly lowered homocysteine and LDL in overweight adults — direct metabolic benefits.

  12. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure

    PubMed ID: 11849459

    Crossover trial in chronic renal failure: glycine betaine lowered post‑methionine load homocysteine (~18%) — supports metabolic homocysteine handling.

Detoxification (7)
  1. Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations

    PubMed ID: 15941890

    Folic acid supplementation raised betaine and decreased homocysteine, supporting improved detoxification capacity via one‑carbon metabolism.

  2. Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism

    PubMed ID: 21247820

    Genetic study on arsenic methylation implicates one‑carbon methylation pathways; betaine donates methyl groups relevant to arsenic detoxification (mechanistic relevance).

  3. Metabolic Signature of Arsenic Exposure and Metabolism: The Folic Acid and Creatine Trial

    PubMed ID: 40668877

    Large study showing higher circulating betaine strongly associated with more complete arsenic methylation (greater %DMA), a direct detoxification pathway (strong associative evidence).

  4. Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial

    PubMed ID: 36717385

    B‑vitamin + betaine trial increased plasma betaine and reduced homocysteine, supporting remethylation pathways used in detox biology.

  5. A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia

    PubMed ID: 31408467

    Homocysteine lowering via betaine/B‑vitamin drink improves methylation capacity (phase II methylation reactions relevant to detoxification).

  6. Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation

    PubMed ID: 14699020

    Strong human evidence that plasma betaine attenuates homocysteine rises after methionine load — supports betaine's role in methylation‑dependent detoxification of homocysteine.

  7. Betaine and choline status modify the effects of folic acid and creatine supplementation on arsenic methylation in a randomized controlled trial of Bangladeshi adults

    PubMed ID: 32918135

    Large RCT in arsenic‑exposed adults: baseline low betaine/choline modified and often worsened arsenic methylation response to folic acid/creatine; shows betaine status is key to arsenic detox pathways.

Heart health (7)
  1. Nutritional supplementation alters associations between one-carbon metabolites and cardiometabolic risk profiles in older adults: a secondary analysis of the Vienna Active Ageing Study

    PubMed ID: 34240265

    In elderly participants, betaine/DMG metabolites correlated with cardiometabolic markers (LDL etc.), but multi‑nutrient/exercise confounding limits causal inference.

  2. Plasma Metabolites From Choline Pathway and Risk of Cardiovascular Disease in the PREDIMED (Prevention With Mediterranean Diet) Study

    PubMed ID: 29080862

    Large prospective study (PREDIMED): choline-pathway metabolite profiles (including betaine ratio) associated with incident CVD; higher betaine/choline ratio linked to lower CVD risk.

  3. Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation

    PubMed ID: 14699020

    Well‑powered human study: higher plasma betaine was linked to smaller homocysteine rises after methionine loading — mechanistically relevant to cardiovascular risk markers.

  4. Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations

    PubMed ID: 15941890

    Large folic acid trial showed folate raises plasma betaine (~15%) and confirmed inverse betaine–homocysteine relationships relevant to heart risk.

  5. Metabolomic Profiles Associated With Blood Pressure Reduction in Response to the DASH and DASH-Sodium Dietary Interventions

    PubMed ID: 37161796

    Betaine‑related metabolites that rise on the DASH diet were associated with reductions in systolic/diastolic blood pressure (direct link to cardiovascular risk).

  6. Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial

    PubMed ID: 36717385

    Large RCT of low‑dose B‑vitamins + 1 g betaine lowered homocysteine by ~10% in hyperhomocysteinemic adults (CV‑relevant biomarker improvement).

  7. A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia

    PubMed ID: 31408467

    Large RCT of a betaine+B‑vitamin drink substantially lowered plasma homocysteine (~24%), a cardiovascular risk biomarker.

Brain health (5)
  1. Eggs early in complementary feeding increase choline pathway biomarkers and DHA: a randomized controlled trial in Ecuador

    PubMed ID: 29092879

    Randomized infant trial: one egg/day for 6 months raised plasma choline/betaine and DHA and was associated with improved linear growth and less stunting — increased nutritional supply supporting development (strongest clinical link to development).

  2. Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke

    PubMed ID: 33467878

    In stroke patients higher plasma betaine and choline were strongly associated with lower odds of cognitive impairment (robust epidemiologic signal).

  3. The impact of micronutrient supplementation in alcohol-exposed pregnancies on reaction time responses of preschoolers in Ukraine

    PubMed ID: 34942330

    Prospective cohort: higher maternal betaine levels associated with better reaction‑time metrics in children (sex‑specific effects on attention/neurodevelopment).

  4. The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people

    PubMed ID: 17537289

    B12+folic acid raised betaine and lowered homocysteine; participants with larger betaine increases had borderline memory improvement — suggestive for cognition.

  5. Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans

    PubMed ID: 22418088

    Higher maternal choline intake raised maternal and fetal choline-related metabolites (including betaine), supporting potential fetal/infant brain nutrient supply.

Cell health (4)
  1. Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial

    PubMed ID: 36717385

    B‑vitamins + betaine increased plasma betaine and reduced homocysteine (methylation pathway support) in an RCT.

  2. A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia

    PubMed ID: 31408467

    Betaine‑containing drink substantially lowered homocysteine and increased circulating betaine — supports enhanced methylation capacity and cellular biochemical function.

  3. Betaine and choline status modify the effects of folic acid and creatine supplementation on arsenic methylation in a randomized controlled trial of Bangladeshi adults

    PubMed ID: 32918135

    Baseline betaine/choline status modified response of arsenic methylation and other metabolites, indicating impact on methylation pathways and cellular detox functions.

  4. Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation

    PubMed ID: 14699020

    Plasma betaine predicted a reduced homocysteine response to methionine loading — indicates functional capacity of betaine‑dependent remethylation.

Weight management (3)
  1. Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program

    PubMed ID: 26861782

    DPP cohort: higher baseline betaine associated with lower incident diabetes and lifestyle raised betaine, implying metabolic/weight-control relevance.

  2. Metabolite Biomarkers Linking a High-Fiber Rye Intervention with Cardiometabolic Risk Factors: The RyeWeight Study

    PubMed ID: 40838659

    High‑rye diet raised betainized metabolites that correlated with weight and fat‑loss markers (associational dietary evidence).

  3. Use of a Micronutrient Cocktail to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Adults with Obesity: A Randomized, Double-Blinded Pilot Clinical Trial

    PubMed ID: 39202647

    Multi‑nutrient trial including betaine reduced BMI and liver fat vs placebo (cannot isolate betaine).

Healthy aging (3)
  1. Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial

    PubMed ID: 36717385

    Homocysteine lowering in adults with high baseline levels could be protective across aging outcomes tied to methylation/CV risk.

  2. The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people

    PubMed ID: 17537289

    B12+folic acid trial: tHcy lowered and betaine rose ~38%; participants with greatest betaine increases had borderline memory improvements — suggests possible cognitive/aging relevance.

  3. A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia

    PubMed ID: 31408467

    Homocysteine reduction in a large trial is relevant to aging/CV risk pathways.

Illness recovery (3)
  1. Use of wet-to-moist cleansing with different irrigation solutions to reduce bacterial bioburden in chronic wounds

    PubMed ID: 30307816

    Large cohort: betaine+zinc+polihexanide irrigation produced the largest reduction in wound bacterial burden (supports faster wound recovery).

  2. Effects of chronic betaine supplementation on performance in professional young soccer players during a competitive season: a double blind, randomized, placebo-controlled trial

    PubMed ID: 34663363

    14‑week betaine improved strength/jump/VO2 in athletes — performance gains often accompany better recovery; direct recovery markers not primary but relevant.

  3. Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: a single-blind RCT

    PubMed ID: 26947697

    RCT: a propylbetaine‑containing wound cleanser improved inflammatory signs and wound healing measures vs saline (topical effect).

Muscle maintenance (3)
  1. The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults

    PubMed ID: 37764658

    Older adults with low dietary choline (proxy for lower betaine) gained substantially less strength during 12 weeks of resistance training (direct functional association).

  2. Effects of chronic betaine supplementation on performance in professional young soccer players during a competitive season: a double blind, randomized, placebo-controlled trial

    PubMed ID: 34663363

    14‑week 2 g/day betaine RCT showed consistent strength gains (bench/leg press) and jump improvements in youth athletes.

  3. Betaine supplementation improves CrossFit performance and increases testosterone levels, but has no influence on Wingate power: randomized crossover trial

    PubMed ID: 37409757

    CrossFit trial showed improved circuit performance and modest testosterone rise; performance gains include muscular components.

Workout performance (3)
  1. Effects of chronic betaine supplementation on performance in professional young soccer players during a competitive season: a double blind, randomized, placebo-controlled trial

    PubMed ID: 34663363

    Well‑controlled RCT in youth soccer players: 14 weeks of 2 g/day betaine produced clear, sizable improvements in jump height, strength and VO2 estimates.

  2. Betaine supplementation improves CrossFit performance and increases testosterone levels, but has no influence on Wingate power: randomized crossover trial

    PubMed ID: 37409757

    CrossFit RCT (n=43) showed a reproducible improvement in a 17‑min functional workout and modest testosterone rise with betaine.

  3. The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults

    PubMed ID: 37764658

    Lower dietary choline (and inferred lower betaine) associated with smaller strength gains in older adults doing resistance training (supports role in performance/adaptation).

Liver support (2)
  1. Use of a Micronutrient Cocktail to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Adults with Obesity: A Randomized, Double-Blinded Pilot Clinical Trial

    PubMed ID: 39202647

    Randomized trial of a supplement mix that included betaine produced clinically meaningful reductions in liver steatosis and stiffness (effect cannot be attributed solely to betaine).

  2. Metabolic Signature of Arsenic Exposure and Metabolism: The Folic Acid and Creatine Trial

    PubMed ID: 40668877

    Higher circulating betaine associated with greater arsenic methylation (hepatic methylation processes), implying improved hepatic detox pathways (associational).

Body composition (2)
  1. Metabolite Biomarkers Linking a High-Fiber Rye Intervention with Cardiometabolic Risk Factors: The RyeWeight Study

    PubMed ID: 40838659

    Rye diet increased betainized metabolites that correlated inversely with weight/fat loss (dietary correlations with leaner composition).

  2. Use of a Micronutrient Cocktail to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Adults with Obesity: A Randomized, Double-Blinded Pilot Clinical Trial

    PubMed ID: 39202647

    Supplement mix containing betaine reduced liver fat and BMI vs placebo in adults with obesity (clinical evidence but multi‑ingredient).

Digestive support (2)
  1. Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis: A Randomized Placebo-Controlled Trial

    PubMed ID: 26465792

    Randomized controlled trial in children with cystic fibrosis: a choline-rich structured lipid (increasing choline/betaine) improved fat absorption (CFA) and related biomarkers over 12 months.

  2. Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth

    PubMed ID: 17824884

    Topical oral products containing betaine (plus olive oil, xylitol) increased unstimulated salivary flow and reduced xerostomia symptoms in medicated patients — directly improves oral digestion/comfort.

Acne (2)
  1. Male tolerance study of 1% C31G

    PubMed ID: 15325891

    Daily application of 1% C31G (contains cetyl betaine) caused mild, acceptable penile symptoms in a minority — indicates reasonable tolerability.

  2. Effects of a betaine-containing toothpaste on subjective symptoms of dry mouth: a randomized clinical trial

    PubMed ID: 12761586

    Randomized crossover trial: betaine‑containing toothpaste reduced patient‑reported dry lips and eating problems vs other pastes.

Focus & concentration (2)
  1. Ketogenic diet is less effective in ameliorating depression and anxiety in obesity than Mediterranean diet: A pilot study for exploring the GUT-brain axis

    PubMed ID: 41197688

    Pilot diet trial with fecal transplant follow‑up: Mediterranean diet improved depressive symptoms and fecal transfers from KD subjects altered mouse behaviour and increased brain betaine — indirect evidence linking betaine‑related microbiota/metabolite changes to mood.

  2. Effects of a pre-workout supplement on lean mass, muscular performance, subjective workout experience and biomarkers of safety

    PubMed ID: 24465156

    Pre-workout containing betaine increased perceived energy and focus in a randomized trial (subjective improvement; multi-ingredient product).

Similar by evidence

Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.

Products with Betaine

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2781 products whose verified label declares Betaine — not every bottle that mentions it in a title.

Being studied right now

Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.