Chlorogenic Acid
16 benefits mapped to clinical evidence across supplements.
Dose per serving from research
43 study groups in 27 studies say how much Chlorogenic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 53% of 43 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mg or less | 2 |
| 100 mg to 250 mg | 6 |
| 250 mg to 500 mg | 23 |
| 500 mg to 1 g | 8 |
| 1 g to 2.5 g | 3 |
| over 2.5 g | 1 |
Commonly used together
17 of 43 study groups took Chlorogenic Acid with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Caffeine | 12 |
Benefit Evidence
Endothelial function +FMD
Blood pressure/lipids ↓
Insulin resistance/lipids ↓
Oxidative lipids −71%
Cognitive/BP and hot flushes
Antioxidant defenses +21-75%
Blood flow/oxygenation ↑
Attention/mood slightly better
Cognition/markers improved
Oxidative lipids −71%
Cognitive/BP and hot flushes
Antioxidant defenses +21-75%
Blood flow/oxygenation ↑
Attention/mood slightly better
Cognition/markers improved
Research sources
Metabolism (11)
- Acute Dose-Response Effectiveness of Combined Catechins and Chlorogenic Acids on Postprandial Glycemic Responses in Healthy Men: Results from Two Randomized Studies
PubMed ID: 36771483
Acute co‑ingestion of catechins + CGAs improved GLP‑1 and postprandial glycemia (dose–response studies).
- Short-term effects of a combined nutraceutical of insulin-sensitivity, lipid level and indexes of liver steatosis: a double-blind, randomized, cross-over clinical trial
PubMed ID: 25886384
Crossover trial of berberine + CGA improved LDL, triglycerides and HOMA‑IR; combined product limits CGA attribution but supports metabolic benefit.
- A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-Obesity: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 36678333
6‑month nutraceutical with CGA+luteolin improved weight, glycemic and lipid markers in pre‑obesity subgroup.
- Effect of Blueberin on fasting glucose, C-reactive protein and plasma aminotransferases, in female volunteers with diabetes type 2: double-blind, placebo controlled clinical study
PubMed ID: 17261891
4‑week RCT in type 2 diabetes showed a large drop in fasting glucose (−27%) though intervention was multi‑ingredient (blueberry extract contains CGA).
- A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract (Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk
PubMed ID: 33374524
Maté extract produced within‑group fasting glucose reductions and HDL improvements in higher‑risk subgroups.
- The Metabolic Effects of Cynara Supplementation in Overweight and Obese Class I Subjects with Newly Detected Impaired Fasting Glycemia: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
PubMed ID: 33126534
Cynara (CGA‑rich) extract for 8 weeks improved fasting glycemia, HOMA and lipids in overweight/obese with impaired fasting glycemia.
- Helianthus annuus Seed Extract Affects Weight and Body Composition of Healthy Obese Adults during 12 Weeks of Consumption: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
PubMed ID: 31096648
Sunflower seed extract standardized for CGAs (500 mg/day) for 12 weeks produced greater reductions in weight and waist in obese adults.
- Altilix(®) Supplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 31731527
6‑month artichoke extract (CGA + luteolin) improved weight, glycemia, lipids and multiple metabolic indices in metabolic‑syndrome subjects.
- Coffee Abundant in Chlorogenic Acids Reduces Abdominal Fat in Overweight Adults: A Randomized, Double-Blind, Controlled Trial
PubMed ID: 31315279
12‑week CGA‑rich instant coffee significantly reduced visceral fat area, total abdominal fat and waist circumference in overweight adults.
- Three-arm, placebo-controlled, randomized clinical trial evaluating the metabolic effect of a combined nutraceutical containing a bergamot standardized flavonoid extract in dyslipidemic overweight subjects
PubMed ID: 31225673
8‑week multi‑ingredient nutraceutical containing CGA improved lipids and insulin‑resistance markers in overweight dyslipidemic participants (multi‑component).
- Effect of Chlorogenic Acid Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance
PubMed ID: 29261010
12‑week CGA (400 mg TID) improved fasting glucose, insulin sensitivity (Matsuda), and reduced weight/lipids in impaired glucose tolerance.
Blood sugar (10)
- Effect of Blueberin on fasting glucose, C-reactive protein and plasma aminotransferases, in female volunteers with diabetes type 2: double-blind, placebo controlled clinical study
PubMed ID: 17261891
4‑week T2DM RCT reported substantial fasting glucose reduction (multi‑ingredient blueberry product containing CGA).
- A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-Obesity: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 36678333
Nutraceutical improved HbA1c and insulin resistance markers over 6 months in pre‑obesity subgroup.
- A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract (Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk
PubMed ID: 33374524
Maté extract produced robust within‑group fasting glucose reductions; between‑group effects modest.
- The Metabolic Effects of Cynara Supplementation in Overweight and Obese Class I Subjects with Newly Detected Impaired Fasting Glycemia: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
PubMed ID: 33126534
Cynara (CGA‑rich) extract improved fasting glycemia, insulin and HOMA markers in impaired fasting glycemia group.
- Altilix(®) Supplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 31731527
6‑month Altilix (CGA+luteolin) improved HbA1c, HOMA‑IR and other glycemic markers in metabolic‑syndrome patients.
- Effect of Chlorogenic Acid Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance
PubMed ID: 29261010
12‑week CGA improved fasting glucose and insulin sensitivity (Matsuda) in impaired glucose tolerance subjects.
- Effect of emulin on blood glucose in type 2 diabetics
PubMed ID: 23444965
Emulin (multi‑component with CGA) modestly lowered fasting and postprandial glucose in type 2 diabetics.
- The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people
PubMed ID: 18035001
CGA‑enriched coffee acutely reduced glucose absorption and led to greater longer‑term weight loss (glycemic benefit).
- Clinical trial of Cecropia obtusifolia and Marrubium vulgare leaf extracts on blood glucose and serum lipids in type 2 diabetics
PubMed ID: 15636168
Cecropia infusion containing CGA reduced fasting glucose in poorly controlled T2D (adjunct therapy trial).
- Acute Dose-Response Effectiveness of Combined Catechins and Chlorogenic Acids on Postprandial Glycemic Responses in Healthy Men: Results from Two Randomized Studies
PubMed ID: 36771483
Acute studies found minimum effective doses of catechins + CGAs increased GLP‑1 and reduced postprandial glucose and GIP.
Heart health (8)
- Altilix(®) Supplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 31731527
Artichoke extract (CGA+luteolin) improved lipids and vascular markers (FMD, cIMT) over 6 months in metabolic syndrome.
- Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension
PubMed ID: 29330659
Single intake of high‑CGA/low‑HHQ coffee improved FMD and lowered oxidative stress in borderline/stage‑1 hypertensives.
- Moderate consumption of a soluble green/roasted coffee rich in caffeoylquinic acids reduces cardiovascular risk markers: results from a randomized, cross-over, controlled trial in healthy and hypercholesterolemic subjects
PubMed ID: 29858625
8‑week green/roasted coffee reduced TC/LDL/VLDL/TG, lowered BP and improved antioxidant markers.
- Hydroxyhydroquinone-free coffee: a double-blind, randomized controlled dose-response study of blood pressure
PubMed ID: 17951035
Large RCT demonstrated dose‑dependent BP lowering with increasing CGA in HHQ‑free coffee.
- Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials
PubMed ID: 28012692
Acute randomized crossover: CGA‑rich coffee and purified 5‑CQA improved flow‑mediated dilation (FMD) in humans with changes paralleling plasma CGA metabolites.
- Three-arm, placebo-controlled, randomized clinical trial evaluating the metabolic effect of a combined nutraceutical containing a bergamot standardized flavonoid extract in dyslipidemic overweight subjects
PubMed ID: 31225673
Multi‑ingredient nutraceutical including CGA improved blood lipids (LDL, TG) which are cardiovascular risk factors.
- Changes in the plasma lipidome of healthy subjects after coffee consumption reveal potential cardiovascular benefits: A randomized controlled trial
PubMed ID: 34648905
Marked decreases in oxysterols and FFAs and increases in cholesteryl esters indicate favorable changes in lipid biology relevant to atherogenesis.
- Short-term effects of a combined nutraceutical of insulin-sensitivity, lipid level and indexes of liver steatosis: a double-blind, randomized, cross-over clinical trial
PubMed ID: 25886384
Berberine + CGA lowered LDL and triglycerides in overweight subjects, supporting improved lipid‑related heart risk profile.
Cholesterol (8)
- Altilix(®) Supplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 31731527
Artichoke extract (CGA+luteolin) improved TC/TG/LDL over 6 months in metabolic syndrome subjects.
- Helianthus annuus Seed Extract Affects Weight and Body Composition of Healthy Obese Adults during 12 Weeks of Consumption: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
PubMed ID: 31096648
Sunflower seed extract standardized for CGAs reduced cholesterol vs placebo in obese adults on hypocaloric diet.
- Changes in the plasma lipidome of healthy subjects after coffee consumption reveal potential cardiovascular benefits: A randomized controlled trial
PubMed ID: 34648905
High‑CGA coffee increased cholesteryl esters and markedly reduced oxysterols, indicating favorable shifts in lipid composition relevant to cholesterol handling.
- Three-arm, placebo-controlled, randomized clinical trial evaluating the metabolic effect of a combined nutraceutical containing a bergamot standardized flavonoid extract in dyslipidemic overweight subjects
PubMed ID: 31225673
8‑week multi‑ingredient nutraceutical containing CGA improved LDL and triglycerides in overweight dyslipidemic participants.
- Effects of the Consumption of Low-Fat Cooked Ham with Reduced Salt Enriched with Antioxidants on the Improvement of Cardiovascular Health: A Randomized Clinical Trial
PubMed ID: 33925704
Antioxidant‑enriched ham (includes CGA) reduced oxidized LDL, a marker of atherogenic oxidized cholesterol.
- Short-term effects of a combined nutraceutical of insulin-sensitivity, lipid level and indexes of liver steatosis: a double-blind, randomized, cross-over clinical trial
PubMed ID: 25886384
Berberine + CGA crossover lowered LDL‑C and triglycerides and improved HOMA‑IR; strong lipid effects though product combined agents.
- Clinical trial of Cecropia obtusifolia and Marrubium vulgare leaf extracts on blood glucose and serum lipids in type 2 diabetics
PubMed ID: 15636168
Cecropia infusion (contains CGA) reduced total cholesterol and triglycerides in poorly controlled T2D adjunct trial.
- Moderate consumption of a soluble green/roasted coffee rich in caffeoylquinic acids reduces cardiovascular risk markers: results from a randomized, cross-over, controlled trial in healthy and hypercholesterolemic subjects
PubMed ID: 29858625
8‑week trial showed significant reductions in TC, LDL‑C, VLDL and TG with green/roasted coffee.
Weight management (7)
- Consumption of a Coffee Rich in Phenolic Compounds May Improve the Body Composition of People with Overweight or Obesity: Preliminary Insights from a Randomized, Controlled and Blind Crossover Study
PubMed ID: 39275165
Replacing habitual coffee with CGA‑rich, lightly roasted coffee modestly reduced body fat % over 12 weeks.
- Novel Multi-Ingredient Supplement Facilitates Weight Loss and Improves Body Composition in Overweight and Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 37686725
12‑week RCT of a seven‑ingredient supplement (includes green coffee/CGAs) produced modest weight and fat mass loss (−2.2 kg), but attribution to CGA alone is uncertain.
- The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people
PubMed ID: 18035001
CGA‑enriched instant coffee acutely reduced glucose absorption and produced larger 12‑week weight loss vs regular instant coffee.
- Coffee Abundant in Chlorogenic Acids Reduces Abdominal Fat in Overweight Adults: A Randomized, Double-Blind, Controlled Trial
PubMed ID: 31315279
12‑week CGA‑rich instant coffee significantly reduced visceral fat area, TFA and waist circumference in overweight adults.
- Altilix(®) Supplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 31731527
6‑month artichoke extract improved body weight, BMI and waist in metabolic‑syndrome subjects.
- Helianthus annuus Seed Extract Affects Weight and Body Composition of Healthy Obese Adults during 12 Weeks of Consumption: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
PubMed ID: 31096648
Sunflower seed extract standardized for CGAs (12 weeks) led to greater weight and waist reductions vs placebo on hypocaloric diet.
- A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-Obesity: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 36678333
6‑month nutraceutical with CGA+luteolin improved weight in pre‑obesity subgroup.
Antioxidant (6)
- Acute reduction of serum 8-iso-PGF2-alpha and advanced oxidation protein products in vivo by a polyphenol-rich beverage; a pilot clinical study with phytochemical and in vitro antioxidant characterization
PubMed ID: 21676230
Acute human RCT with 225 mg CGA-containing polyphenol beverage showed large decreases in oxidative stress markers (8‑iso‑PGF2α, AOPP) though multi‑ingredient.
- Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension
PubMed ID: 29330659
Single intake of high‑CGA/low‑HHQ coffee lowered oxidative stress marker (8‑isoprostane) with FMD improvement.
- Moderate consumption of a soluble green/roasted coffee rich in caffeoylquinic acids reduces cardiovascular risk markers: results from a randomized, cross-over, controlled trial in healthy and hypercholesterolemic subjects
PubMed ID: 29858625
8‑week green/roasted coffee increased plasma antioxidant capacity (ORAC/FRAP) and reduced MDA/protein carbonyls.
- Coffee Consumption Increases the Antioxidant Capacity of Plasma and Has No Effect on the Lipid Profile or Vascular Function in Healthy Adults in a Randomized Controlled Trial
PubMed ID: 26843588
Acute coffee increased circulating CGA metabolites and FRAP (antioxidant capacity) at 1 h but no 8‑week antioxidant endpoint changes.
- Effects of the Consumption of Low-Fat Cooked Ham with Reduced Salt Enriched with Antioxidants on the Improvement of Cardiovascular Health: A Randomized Clinical Trial
PubMed ID: 33925704
8‑week antioxidant‑enriched food (includes CGA) lowered oxidized LDL and MDA, indicating reduced oxidative damage.
- Changes in the plasma lipidome of healthy subjects after coffee consumption reveal potential cardiovascular benefits: A randomized controlled trial
PubMed ID: 34648905
8‑week RCT with high‑CGA coffee markedly reduced circulating oxidized lipids (oxysterols −71%) and FFAs, strong biochemical antioxidant/oxidative‑damage signal.
Inflammation (6)
- To explore the regulatory effect of Buyang Huanwu Decoction on cerebral infarction based on quantitative proteomics
PubMed ID: 36813112
Significant IL‑6 reduction observed with the multi‑herb intervention that includes chlorogenic acid, supporting anti‑inflammatory effect at the product level though specific contribution of chlorogenic acid is uncertain.
- Changes in the plasma lipidome of healthy subjects after coffee consumption reveal potential cardiovascular benefits: A randomized controlled trial
PubMed ID: 34648905
Big reductions in oxidized lipids and FFAs are consistent with reduced inflammatory lipid signaling after high‑CGA coffee.
- Effects of the Consumption of Low-Fat Cooked Ham with Reduced Salt Enriched with Antioxidants on the Improvement of Cardiovascular Health: A Randomized Clinical Trial
PubMed ID: 33925704
hs‑CRP decreased after 8 weeks of antioxidant‑enriched product (includes CGA), showing reduced systemic inflammation markers.
- A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract (Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk
PubMed ID: 33374524
Maté extract reduced IL‑6 (fasted) by ~19% and showed anti‑inflammatory signals in higher‑risk subgroups.
- Effect of Blueberin on fasting glucose, C-reactive protein and plasma aminotransferases, in female volunteers with diabetes type 2: double-blind, placebo controlled clinical study
PubMed ID: 17261891
T2DM RCT reported large CRP reduction (−59%) after blueberry extract containing CGA, indicating anti‑inflammatory effect though multi‑ingredient.
- Acute reduction of serum 8-iso-PGF2-alpha and advanced oxidation protein products in vivo by a polyphenol-rich beverage; a pilot clinical study with phytochemical and in vitro antioxidant characterization
PubMed ID: 21676230
Acute polyphenol drink lowered oxidative stress biomarkers and trended to CRP reduction—indicative of anti‑inflammatory potential.
Liver support (4)
- Effect of Blueberin on fasting glucose, C-reactive protein and plasma aminotransferases, in female volunteers with diabetes type 2: double-blind, placebo controlled clinical study
PubMed ID: 17261891
Blueberry extract RCT in T2DM lowered ALT (improved liver enzyme), suggesting hepatic benefit though multi‑ingredient product.
- A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-Obesity: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 36678333
Nutraceutical with CGA+luteolin improved metabolic and vascular markers; trial reported hepatic benefits in parent studies.
- Altilix(®) Supplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 31731527
Artichoke extract (CGA+luteolin) significantly improved AST/ALT, AST/ALT ratio and fatty liver index over 6 months.
- Novel Multi-Ingredient Supplement Facilitates Weight Loss and Improves Body Composition in Overweight and Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 37686725
12‑week multi‑ingredient supplement including green coffee/CGAs improved liver biomarkers and EV‑miRNA profiles consistent with hepatic benefit.
Healthy aging (4)
- Effects of the Consumption of Low-Fat Cooked Ham with Reduced Salt Enriched with Antioxidants on the Improvement of Cardiovascular Health: A Randomized Clinical Trial
PubMed ID: 33925704
Lowered oxidized LDL and MDA after antioxidant‑enriched food suggests reduced cumulative oxidative damage relevant to healthy aging.
- Effect of Chlorogenic Acids on Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 30241302
16 weeks of 300 mg CGA produced modest improvements in attention/executive measures and increased blood proteins linked to brain health.
- Changes in the plasma lipidome of healthy subjects after coffee consumption reveal potential cardiovascular benefits: A randomized controlled trial
PubMed ID: 34648905
Large reductions in oxidized lipids (oxysterols) are mechanistically linked to processes relevant to aging and age‑related disease risk.
- Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial
PubMed ID: 33297409
CGA tablets reduced menopausal hot flushes and symptom scores, supporting symptomatic aspects of healthy aging in women.
Brain health (4)
- To explore the regulatory effect of Buyang Huanwu Decoction on cerebral infarction based on quantitative proteomics
PubMed ID: 36813112
Significant improvement in NIHSS and Barthel Index in stroke patients indicates meaningful neurological/functional benefit from the multi‑herb decoction containing chlorogenic acid; attribution to chlorogenic acid specifically is limited.
- Effect of Chlorogenic Acids on Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 30241302
16‑week CGA (300 mg/day) produced modest improvements in psychomotor speed/executive measures and increased brain‑related blood proteins (TTR).
- Acute cognitive performance and mood effects of coffee berry and apple extracts: A randomised, double blind, placebo controlled crossover study in healthy humans
PubMed ID: 34380382
High‑dose coffeeberry extract acutely increased alertness and produced small improvements on some cognitive tasks.
- A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans
PubMed ID: 32731478
Single‑dose coffee‑berry (CGA‑rich) beverages increased frontal oxygenation and reduced mental fatigue/subjective fatigue, supporting acute cognitive/brain effects (multi‑ingredient).
Immune support (3)
- Black chokeberry juice (Aronia melanocarpa) reduces incidences of urinary tract infection among nursing home residents in the long term--a pilot study
PubMed ID: 25026919
6‑month nursing‑home pilot: chokeberry juice (contains CGAs) associated with fewer UTIs and less antibiotic use—supports enhanced host defense/immune‑related outcomes.
- Effects of the Consumption of Low-Fat Cooked Ham with Reduced Salt Enriched with Antioxidants on the Improvement of Cardiovascular Health: A Randomized Clinical Trial
PubMed ID: 33925704
Reduced hs‑CRP after 8 weeks of antioxidant‑enriched food (includes CGA) indicates anti‑inflammatory/immune‑modulating effect.
- Effect of Blueberin on fasting glucose, C-reactive protein and plasma aminotransferases, in female volunteers with diabetes type 2: double-blind, placebo controlled clinical study
PubMed ID: 17261891
4‑week RCT in T2DM lowered CRP substantially (−59%) but used a multi‑ingredient blueberry extract, limiting CGA attribution.
Cell health (3)
- Effects of the Consumption of Low-Fat Cooked Ham with Reduced Salt Enriched with Antioxidants on the Improvement of Cardiovascular Health: A Randomized Clinical Trial
PubMed ID: 33925704
Decreases in oxidized LDL and MDA indicate protection from oxidative cellular damage (multi‑antioxidant product including CGA).
- Changes in the plasma lipidome of healthy subjects after coffee consumption reveal potential cardiovascular benefits: A randomized controlled trial
PubMed ID: 34648905
Marked reductions in oxidized lipids (oxysterols) and FFAs imply reduced lipid oxidative damage at the cellular level after CGA‑rich coffee.
- Novel Multi-Ingredient Supplement Facilitates Weight Loss and Improves Body Composition in Overweight and Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 37686725
12‑week multi‑ingredient supplement including green coffee/CGAs improved liver biomarkers and EV miRNA profiles that relate to cellular health.
Skin health (3)
- Coffee polyphenols extracted from green coffee beans improve skin properties and microcirculatory function
PubMed ID: 28675091
8‑week coffee polyphenols (270 mg/day CPPs) improved skin hydration, reduced TEWL and enhanced microcirculation in women with dry skin.
- Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 32294883
12‑week apple polyphenol (contains CGA) reduced UV‑induced pigmentation and erythema vs placebo.
- Brightening effect of Ziziphus jujuba (jujube) fruit extract on facial skin: A randomized, double-blind, clinical study
PubMed ID: 35460145
8‑week jujube syrup (contains CGA) reduced facial hyperpigmentation counts/area vs placebo.
Vitality (3)
- Acute Cardiovascular Effects of Turkish Coffee Assessed by VO(2) Test: A Randomized Crossover Trial
PubMed ID: 40077691
Single serving of Turkish coffee increased subjective energy in young women (acute trial).
- A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans
PubMed ID: 32731478
Coffee‑berry (CGA‑rich) beverages increased frontal oxygenation and reduced subjective mental fatigue and improved mood acutely—supports energy/vitality.
- Acute cognitive performance and mood effects of coffee berry and apple extracts: A randomised, double blind, placebo controlled crossover study in healthy humans
PubMed ID: 34380382
High‑dose coffeeberry extract increased subjective alertness acutely in healthy adults.
Blood pressure (2)
- Hydroxyhydroquinone-free coffee: a double-blind, randomized controlled dose-response study of blood pressure
PubMed ID: 17951035
Large randomized trial showed dose‑dependent BP lowering with increasing CGA in HHQ‑free coffee.
- Moderate consumption of a soluble green/roasted coffee rich in caffeoylquinic acids reduces cardiovascular risk markers: results from a randomized, cross-over, controlled trial in healthy and hypercholesterolemic subjects
PubMed ID: 29858625
8‑week green/roasted coffee reduced both systolic and diastolic blood pressure in adults.
Illness recovery (1)
- To explore the regulatory effect of Buyang Huanwu Decoction on cerebral infarction based on quantitative proteomics
PubMed ID: 36813112
Significant improvements in NIHSS and Barthel Index indicate clinical recovery benefit in stroke patients from the multi‑herb decoction containing chlorogenic acid, though the effect cannot be attributed solely to chlorogenic acid.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Chlorogenic Acid
Search all25 products whose verified label declares Chlorogenic Acid — not every bottle that mentions it in a title.