Black Walnut
15 benefits mapped to clinical evidence across supplements.
Dose per serving from products
136 products in our catalogue print how much Black Walnut a serving holds.
Most common: 50 mg to 100 mg and 250 mg to 500 mg, 29% of 136 products each.
| Dose per serving | Products |
|---|---|
| 25 mg or less | 3 |
| 25 mg to 50 mg | 6 |
| 50 mg to 100 mg | 40 |
| 100 mg to 250 mg | 31 |
| 250 mg to 500 mg | 40 |
| 500 mg to 1 g | 14 |
| over 1 g | 2 |
Benefit Evidence
Lipids + HbA1c LDL -6%, HbA1c -0.2%
Glucose/insulin control Insulin response +26%
Lipids + HbA1c LDL -6%, HbA1c -0.2%
Glucose/insulin control Insulin response +26%
Research sources
Blood circulation (21)
- Replacing Saturated Fats with Unsaturated Fats from Walnuts or Vegetable Oils Lowers Atherogenic Lipoprotein Classes Without Increasing Lipoprotein(a)
PubMed ID: 31909809
Walnut diet reduced LDL, non‑HDL and total cholesterol more than oleic‑acid diet in a controlled crossover (lipid benefits supportive of circulation).
- Effect of Weight Reduction Diets Containing Fish, Walnut or Fish plus Walnut on Cardiovascular Risk Factors in Overweight and Obese Women
PubMed ID: 31679359
In overweight women losing weight, fish+walnut diet produced modest reductions in SBP, fasting glucose, and LDL versus fish or walnut alone (cardiometabolic improvement).
- Effects of short-term walnut consumption on human microvascular function and its relationship to plasma epoxide content
PubMed ID: 26396054
Postmenopausal women: 40 g/day walnuts improved small‑vessel function (RHI) linked to increases in vasodilatory epoxide metabolites—strong microvascular evidence.
- Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study
PubMed ID: 26813890
PREDIMED data: higher ALA intake (largely from walnuts) associated with lower all‑cause mortality and seafood n‑3 with less fatal CVD—observational cardiovascular benefit.
- Replacing Saturated Fat With Walnuts or Vegetable Oils Improves Central Blood Pressure and Serum Lipids in Adults at Risk for Cardiovascular Disease: A Randomized Controlled-Feeding Trial
PubMed ID: 31039663
6‑week replacement of saturated fat with walnuts lowered central diastolic BP and improved blood lipids in adults at CVD risk (controlled feeding RCT).
- A Walnut-Enriched Diet for 2 Years Changes the Serum Oxylipin Profile in Healthy Older Persons
PubMed ID: 38081585
Long‑term shifts in oxylipins toward ALA‑derived vasoprotective mediators and away from AA‑derived proinflammatory mediators support vascular health mechanisms.
- Effects of walnut consumption as part of a low-fat, low-cholesterol diet on serum cardiovascular risk factors
PubMed ID: 12463111
Adding walnuts to a low‑fat diet lowered triglycerides and produced favorable lipid changes.
- Antihypertriglyceridemic effect of walnut oil
PubMed ID: 12934760
Walnut oil produced large, significant triglyceride reductions in hyperlipidemic subjects — strong cardio/circulatory lipid benefit.
- Including walnuts in a low-fat/modified-fat diet improves HDL cholesterol-to-total cholesterol ratios in patients with type 2 diabetes
PubMed ID: 15562184
Daily walnuts improved HDL and lowered LDL in type 2 diabetics — relevant to vascular risk.
- Walnut consumption in hyperlipidemic patients
PubMed ID: 16193197
Daily walnuts reduced triglycerides (~17%) and increased HDL, improving lipid risk profile.
- Long-term walnut supplementation without dietary advice induces favorable serum lipid changes in free-living individuals
PubMed ID: 20087377
12‑month supplementation improved total cholesterol and triglycerides in free‑living adults, sustained cardiometabolic benefit.
- Effects of walnuts on endothelial function in overweight adults with visceral obesity: a randomized, controlled, crossover trial
PubMed ID: 23756586
Daily walnuts (56 g) improved endothelial function (FMD) in overweight adults without weight gain (direct vascular benefit).
- Walnut-enriched diet reduces fasting non-HDL-cholesterol and apolipoprotein B in healthy Caucasian subjects: a randomized controlled cross-over clinical trial
PubMed ID: 24360749
Daily walnuts (43 g) for 8 weeks reduced non‑HDL cholesterol and apoB in older adults (clinically meaningful).
- Effects of Diet Composition and Insulin Resistance Status on Plasma Lipid Levels in a Weight Loss Intervention in Women
PubMed ID: 26811166
Walnut‑rich diet (6 months) increased HDL and reduced LDL/TG — favorable long‑term lipid effects.
- Effects of diet composition on weight loss, metabolic factors and biomarkers in a 1-year weight loss intervention in obese women examined by baseline insulin resistance status
PubMed ID: 27733248
12‑month walnut‑rich reduced‑energy diet improved LDL and insulin markers with meaningful weight loss.
- Effects of walnut oil on lipid profiles in hyperlipidemic type 2 diabetic patients: a randomized, double-blind, placebo-controlled trial
PubMed ID: 28394361
90‑day walnut oil RCT in hyperlipidemic T2DM lowered total cholesterol, LDL and TG significantly vs placebo.
- A Walnut-Enriched Diet Reduces Lipids in Healthy Caucasian Subjects, Independent of Recommended Macronutrient Replacement and Time Point of Consumption: a Prospective, Randomized, Controlled Trial
PubMed ID: 28984822
Large randomized crossover: daily walnuts (43 g) significantly lowered non‑HDL, LDL, TG and apoB — strong cardiovascular evidence.
- Walnut consumption in a weight reduction intervention: effects on body weight, biological measures, blood pressure and satiety
PubMed ID: 29202751
6‑month RCT in overweight adults showed modest lowering of total cholesterol and a ~6 mmHg within‑group SBP drop in walnut group.
- Effect of individualised dietary advice for weight loss supplemented with walnuts on blood pressure: the HealthTrack study
PubMed ID: 29559724
Secondary analysis linked walnut supplementation and individualized counseling to slightly greater BP reductions associated with higher urinary potassium.
- Effect of a Walnut Diet on Office and 24-Hour Ambulatory Blood Pressure in Elderly Individuals
PubMed ID: 30879358
Large 2‑year randomized substudy found clinically meaningful 24‑hour systolic BP reductions (especially in those with higher baseline ambulatory BP) with daily walnuts.
- Effects of Walnut Consumption for 2 Years on Lipoprotein Subclasses Among Healthy Elders: Findings From the WAHA Randomized Controlled Trial
PubMed ID: 34455809
Two‑year RCT showed modest but statistically significant reductions in total cholesterol, LDL‑C and atherogenic particles.
Wellbeing (12)
- Effect of Walnut Supplementation on Dietary Polyphenol Intake and Urinary Polyphenol Excretion in the Walnuts and Healthy Aging Study
PubMed ID: 36904251
Large trial shows increased intake of bioactive polyphenols with daily walnuts, a plausible contributor to general wellness.
- Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study
PubMed ID: 26813890
Large PREDIMED cohort: higher dietary ALA (mainly from walnuts) associated with substantially lower all‑cause mortality (observational).
- Walnut Consumption for Two Years and Leukocyte Telomere Attrition in Mediterranean Elders: Results of a Randomized Controlled Trial
PubMed ID: 30518050
Two‑year RCT subanalysis suggests walnuts may slow leukocyte telomere shortening—consistent with a modest anti‑aging/overall wellness signal.
- Replacing Saturated Fat With Walnuts or Vegetable Oils Improves Central Blood Pressure and Serum Lipids in Adults at Risk for Cardiovascular Disease: A Randomized Controlled-Feeding Trial
PubMed ID: 31039663
Controlled feeding trial in adults at CVD risk showed improvements in central DBP and lipids with walnut replacement of saturated fat, supporting cardiometabolic wellness.
- Walnut-enriched diet reduces fasting non-HDL-cholesterol and apolipoprotein B in healthy Caucasian subjects: a randomized controlled cross-over clinical trial
PubMed ID: 24360749
8‑week walnut intake lowered non‑HDL and apoB in healthy older adults—clinically relevant lipid improvements.
- Effects of Juglans regia L. leaf extract on hyperglycemia and lipid profiles in type two diabetic patients: a randomized double-blind, placebo-controlled clinical trial
PubMed ID: 24462785
Juglans regia leaf extract improved glycemic control and lipids in T2DM (adjunctive clinical benefits).
- Weight loss with a modified Mediterranean-type diet using fat modification: a randomized controlled trial
PubMed ID: 25690866
Modified Mediterranean diet including walnuts produced substantial short‑term weight loss and improved lipids.
- Effects of diet composition on weight loss, metabolic factors and biomarkers in a 1-year weight loss intervention in obese women examined by baseline insulin resistance status
PubMed ID: 27733248
1‑year walnut‑rich reduced‑energy diet produced weight loss and improved LDL/insulin markers (longer‑term clinical benefits).
- A Walnut-Enriched Diet Reduces Lipids in Healthy Caucasian Subjects, Independent of Recommended Macronutrient Replacement and Time Point of Consumption: a Prospective, Randomized, Controlled Trial
PubMed ID: 28984822
Large randomized crossover: 43 g/day walnuts reduced non‑HDL, LDL, TG and apoB — robust cardiovascular/health benefit.
- Walnut consumption in a weight reduction intervention: effects on body weight, biological measures, blood pressure and satiety
PubMed ID: 29202751
6‑month RCT showed walnuts produced modest total‑cholesterol and SBP improvements with comparable weight loss — clinically relevant wellness signals.
- Effects of Long-Term Walnut Supplementation on Body Weight in Free-Living Elderly: Results of a Randomized Controlled Trial
PubMed ID: 30231466
Two‑year trial in elders showed walnuts do not cause weight gain and increased RBC ALA (safety/nutrient adherence evidence).
- Effects of Walnut Consumption for 2 Years on Lipoprotein Subclasses Among Healthy Elders: Findings From the WAHA Randomized Controlled Trial
PubMed ID: 34455809
Large 2‑year RCT found modest but consistent reductions in total cholesterol/LDL and atherogenic particles with daily walnuts.
Weight management (8)
- Lifestyle counseling and supplementation with flaxseed or walnuts influence the management of metabolic syndrome
PubMed ID: 20826632
Adding 30 g/day walnuts in a 12‑week lifestyle program improved reversion of central obesity versus counseling alone.
- Does regular walnut consumption lead to weight gain?
PubMed ID: 16277792
Free‑living adults adding ~35 g/day walnuts had only a small, non‑significant weight gain (~0.4 kg) largely explained by energy intake, indicating walnuts won't necessarily cause weight gain.
- Acute consumption of Black walnuts increases fullness and decreases lipid peroxidation in humans
PubMed ID: 31757635
Acute single‑meal study found walnuts increased postprandial satiety vs butter control (supports appetite control).
- Effect of Walnut Predinner Snack on Mealtime Hunger and Nutrient Intake Among University Students
PubMed ID: 34714144
Randomized crossover: a 190‑Cal walnut snack before a meal reduced subsequent meal intake by ≈100 kcal (acute appetite/energy intake effect).
- Effects of Long-Term Walnut Supplementation on Body Weight in Free-Living Elderly: Results of a Randomized Controlled Trial
PubMed ID: 30231466
Two‑year trial showed daily walnuts did not cause weight gain in free‑living elders (support for weight neutrality/safety).
- Walnut consumption in a weight reduction intervention: effects on body weight, biological measures, blood pressure and satiety
PubMed ID: 29202751
6‑month weight‑loss RCT: adding walnuts produced similar weight loss to standard diet (did not impede loss).
- Effects of diet composition on weight loss, metabolic factors and biomarkers in a 1-year weight loss intervention in obese women examined by baseline insulin resistance status
PubMed ID: 27733248
1‑year walnut‑rich reduced‑energy diet produced substantial weight loss comparable to other recommended diets.
- Weight loss with a modified Mediterranean-type diet using fat modification: a randomized controlled trial
PubMed ID: 25690866
Modified Mediterranean‑type diet including walnuts produced substantial short‑term weight loss and lipid benefits in a large RCT.
Nutrition source (6)
- Effects of Long-Term Walnut Supplementation on Body Weight in Free-Living Elderly: Results of a Randomized Controlled Trial
PubMed ID: 30231466
Two‑year walnut supplementation raised RBC alpha‑linolenic acid by ~33% (direct nutrient biomarker increase).
- Food and Nutrient Displacement by Walnut Supplementation in a Randomized Crossover Study
PubMed ID: 35267992
Daily walnuts raised dietary ALA and several minerals (Ca, P, Mg, Zn) in free‑living adults — improved nutrient intake profile.
- Effect of Walnut Supplementation on Dietary Polyphenol Intake and Urinary Polyphenol Excretion in the Walnuts and Healthy Aging Study
PubMed ID: 36904251
Demonstrated clear increase in dietary polyphenol intake from consuming walnuts, indicating nutrient/bioactive enrichment.
- Effects of Walnut Consumption on Mood in Young Adults-A Randomized Controlled Trial
PubMed ID: 27792133
Walnut supplementation substantially increased plasma ALA (+68%), verifying nutrient delivery.
- Structured dietary advice incorporating walnuts achieves optimal fat and energy balance in patients with type 2 diabetes mellitus
PubMed ID: 15983525
Randomized trial in T2D patients: 30 g/day walnuts helped participants meet ALA/PUFA intake targets without increasing total energy—strong nutrient support evidence.
- Validation of a food-frequency questionnaire for measurement of nutrient intake in a dietary intervention study
PubMed ID: 17261227
Validation study shows walnut supplementation reliably increases ALA and PUFA intake as captured by FFQ (direct nutrient evidence).
Digestive support (5)
- Walnuts and Vegetable Oils Containing Oleic Acid Differentially Affect the Gut Microbiota and Associations with Cardiovascular Risk Factors: Follow-up of a Randomized, Controlled, Feeding Trial in Adults at Risk for Cardiovascular Disease
PubMed ID: 31848609
Controlled feeding trial showed walnut diet enriched butyrate‑producing bacteria and polyphenol‑metabolizing microbes, supporting digestive health.
- The Impact of Daily Walnut Consumption on Gastrointestinal Symptoms: A Mixed-Method Study in Healthy Adults
PubMed ID: 39778130
Controlled study reported improved GI symptom scores after three weeks of daily walnuts in healthy young adults.
- The Effects of Walnuts and Academic Stress on Mental Health, General Well-Being and the Gut Microbiota in a Sample of University Students: A Randomised Clinical Trial
PubMed ID: 36432461
Walnuts helped preserve gut microbiome diversity in females during exam stress (16‑week randomized trial).
- A Walnut-Enriched Diet Affects Gut Microbiome in Healthy Caucasian Subjects: A Randomized, Controlled Trial
PubMed ID: 29470389
8‑week walnut feeding produced reproducible shifts in stool microbiota (↑Bifidobacterium, Ruminococcaceae) consistent with prebiotic effects.
- Walnut consumption and gut microbial metabolism: Results of an exploratory analysis from a randomized, crossover, controlled-feeding study
PubMed ID: 37826992
Feeding study showed increased activity/diversity of bacterial genes and specific taxa changes with walnut intake.
Antioxidant (4)
- A Walnut-Enriched Diet for 2 Years Changes the Serum Oxylipin Profile in Healthy Older Persons
PubMed ID: 38081585
Long-term RCT metabolomics: walnut intake raised ALA-derived (anti‑inflammatory) oxylipins and lowered several AA‑derived proinflammatory oxylipins.
- Walnut Consumption for Two Years and Leukocyte Telomere Attrition in Mediterranean Elders: Results of a Randomized Controlled Trial
PubMed ID: 30518050
Two‑year RCT substudy showed less leukocyte telomere shortening with walnuts, consistent with reduced oxidative/aging stress.
- Effect of Walnut Supplementation on Dietary Polyphenol Intake and Urinary Polyphenol Excretion in the Walnuts and Healthy Aging Study
PubMed ID: 36904251
Large RCT showed a substantial increase in dietary polyphenol intake from daily walnuts, supporting antioxidant potential.
- Acute consumption of Black walnuts increases fullness and decreases lipid peroxidation in humans
PubMed ID: 31757635
Acute randomized crossover showed black walnuts lowered postprandial lipid peroxidation vs control (direct oxidative stress marker).
Gut health (4)
- Walnut consumption and gut microbial metabolism: Results of an exploratory analysis from a randomized, crossover, controlled-feeding study
PubMed ID: 37826992
Walnut feeding increased active gene α-diversity and altered bacterial activity (e.g., Gordonibacter) and specific gene expression linked to beneficial pathways.
- A Walnut-Enriched Diet Affects Gut Microbiome in Healthy Caucasian Subjects: A Randomized, Controlled Trial
PubMed ID: 29470389
8‑week randomized crossover feeding study showed significant gut microbiome restructuring with increased Bifidobacterium and butyrate producers.
- The Effects of Walnuts and Academic Stress on Mental Health, General Well-Being and the Gut Microbiota in a Sample of University Students: A Randomised Clinical Trial
PubMed ID: 36432461
16‑week trial found walnut consumption stabilized gut Shannon diversity in females under exam stress (protective microbiome effect).
- Walnuts and Vegetable Oils Containing Oleic Acid Differentially Affect the Gut Microbiota and Associations with Cardiovascular Risk Factors: Follow-up of a Randomized, Controlled, Feeding Trial in Adults at Risk for Cardiovascular Disease
PubMed ID: 31848609
Controlled feeding crossover: walnut diet enriched butyrate‑producers (Roseburia, Eubacterium eligens) and ellagitannin‑metabolizing microbes (Gordonibacter), directly demonstrating microbiome shifts.
Hormone balance (3)
- Effects of Juglans regia L. leaf extract on hyperglycemia and lipid profiles in type two diabetic patients: a randomized double-blind, placebo-controlled clinical trial
PubMed ID: 24462785
Juglans regia leaf extract improved fasting glucose and HbA1c in T2DM — relevant to metabolic/hormonal regulation.
- Differential effects of walnuts vs almonds on improving metabolic and endocrine parameters in PCOS
PubMed ID: 21157477
In PCOS patients walnuts decreased LDL, increased adiponectin and lowered HbA1c, showing metabolic/hormonal shifts relevant to endocrine balance.
- Effects of diet composition on weight loss, metabolic factors and biomarkers in a 1-year weight loss intervention in obese women examined by baseline insulin resistance status
PubMed ID: 27733248
Walnut‑rich diet improved insulin/HOMA in insulin‑resistant women (dietary impact on metabolic hormones).
Mood balance (2)
- The Effects of Walnuts and Academic Stress on Mental Health, General Well-Being and the Gut Microbiota in a Sample of University Students: A Randomised Clinical Trial
PubMed ID: 36432461
Randomized 16‑week feeding trial showed walnuts prevented exam‑period rises in self‑reported depression and reduced stress biomarker changes.
- Effects of Walnut Consumption on Mood in Young Adults-A Randomized Controlled Trial
PubMed ID: 27792133
Randomized crossover: walnut supplementation increased plasma ALA and improved total mood disturbance in young men (sex‑specific benefit).
Mental clarity (2)
- Effects of walnut consumption on cognitive performance in young adults
PubMed ID: 21923981
Randomized crossover in students showed an ~11% improvement in inferential verbal reasoning after walnuts.
- The impact of a walnut-rich breakfast on cognitive performance and brain activity throughout the day in healthy young adults: a crossover intervention trial
PubMed ID: 39924976
Acute double‑blind crossover trial showed faster reaction times and some later‑day memory benefits after a walnut‑rich breakfast.
Detoxification (1)
- Effects of total dietary polyphenols on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial
PubMed ID: 25315667
Nuts‑enriched Mediterranean diet increased urinary polyphenol excretion and plasma NO with BP reductions — plausible detox/antioxidant metabolite increase.
Oral health (1)
- Randomized clinical trial of the effectiveness of complementary therapies for recurrent aphthous stomatitis
PubMed ID: 28238332
Topical walnut extract reduced symptom duration of minor mouth (aphthous) ulcers vs placebo in an RCT (direct oral benefit).
Immune support (1)
- A Walnut-Enriched Diet for 2 Years Changes the Serum Oxylipin Profile in Healthy Older Persons
PubMed ID: 38081585
Shift away from AA‑derived proinflammatory oxylipins supports reduced inflammatory signaling relevant to immune balance.
Sleep quality (1)
- Daily walnut consumption increases 6-sulfatoxymelatonin urinary levels and can improve sleep quality: a randomized crossover trial
PubMed ID: 40791136
Randomized crossover trial (76 participants) showed increased melatonin metabolite and clear improvements in sleep latency and global sleep quality with 40 g/day walnuts.
Vitality (1)
- Daily walnut consumption increases 6-sulfatoxymelatonin urinary levels and can improve sleep quality: a randomized crossover trial
PubMed ID: 40791136
Walnut intake raised melatonin metabolite and improved sleep latency and daytime sleepiness, plausibly improving daytime energy.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Black Walnut
Search all349 products whose verified label declares Black Walnut — not every bottle that mentions it in a title.