supp.fit

Sage

16 benefits mapped to clinical evidence across supplements.

Dose per serving from products

111 products in our catalogue print how much Sage a serving holds.

Most common: 100 mg to 250 mg, 34% of 111 products.

Dose per servingProducts
10 mg or less
3
10 mg to 25 mg
24
25 mg to 50 mg
17
50 mg to 100 mg
4
100 mg to 250 mg
38
250 mg to 500 mg
15
500 mg to 1 g
8
over 1 g
2

Dose per serving from research

12 study groups in 9 studies say how much Sage participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mg to 500 mg, 58% of 12 study groups.

Daily doseStudy groups
250 mg to 500 mg
7
500 mg to 1 g
1
1 g to 2.5 g
1
2.5 g to 5 g
0
5 g to 10 g
0
10 g to 25 g
2
over 25 g
1

See every study group

Benefit Evidence

Depression/anxiety ↓

Mood/alertness ↑

8,797 people
Oral health
Moderate

Gingival bleeding/plaque ↓

Halitosis/VSC ↓

Pain/healing faster

1,064 people

Memory + attention

Alertness +1.6 errors

1,415 people

Respiratory rate ↓

Respiratory comfort ↑

10,259 people

Blood pressure ↓

Systolic −7.3 mmHg

1,936 people
Inflammation
Moderate

Gut recovery; CRP↓

UV redness↓

622 people

Memory/attention +sage

Fatigue/alertness +peppermint

294 people
Metabolism
Moderate

BMI, insulin ↓

TG, MDA ↓

518 people

T-cell shifts

Fatigue relief

9,920 people

Androgen down, ovulation up

Insulin resistance down

252 people
Vitality
Moderate

Fatigue/immune +

Fitness +4.1

221 people
Wellbeing
Moderate

Fatigue/immune +QOL

Fitness/BP +4.1 VO2

189 people

Oxidative stress markers ↓

Antioxidant enzymes ↑

154 people

Sleep maintenance, onset

Daytime sleepiness/functioning

2,784 people

Gut transit +10h

Barrier/oxidative defense improved

410 people

Healing & pain: ~6.7d

Redness/inflammation: reduced

189 people

Research sources

Mood balance (16)
  1. Cognitive behavioral therapy skills via a smartphone app for subthreshold depression among adults in the community: the RESiLIENT randomized controlled trial

    PubMed ID: 40269333

    Smartphone CBT program reduced depressive symptoms in subthreshold depression — behavioral mood benefit.

  2. A randomised double-blind, placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression (the PAX-BD study)

    PubMed ID: 39829389

    Pramipexole in treatment‑resistant bipolar depression showed larger reductions in depressive symptoms and higher response/remission later — relevant dopaminergic mood benefit.

  3. Mindfulness-based cognitive therapy versus treatment as usual after non-remission with NHS Talking Therapies high-intensity psychological therapy for depression: a UK-based clinical effectiveness and cost-effectiveness randomised, controlled, superiority trial

    PubMed ID: 40379363

    MBCT plus usual care produced sustained reductions in depression and anxiety — psychosocial mood support evidence.

  4. Home-based transcranial direct current stimulation for major depressive disorder: 6-month follow-up from randomised sham-controlled trial and open-label treatment phases

    PubMed ID: 40209536

    Home‑based tDCS showed durable clinical response in subset with MDD — neuromodulation mood benefit.

  5. Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults

    PubMed ID: 20937617

    Sage essential oil reduced mental fatigue and increased alertness in healthy adults—supports mood/subjective wellbeing to a moderate degree (acute single‑dose trial).

  6. Effectiveness of Predominantly Group Schema Therapy and Combined Individual and Group Schema Therapy for Borderline Personality Disorder: A Randomized Clinical Trial

    PubMed ID: 35234828

    Schema therapy RCT reduced borderline personality severity and improved functioning — psychotherapeutic mood/affect benefit relevant to mood support.

  7. Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery

    PubMed ID: 16205785

    Acute doses of dried sage leaf decreased anxiety (at 300 mg) and increased measures such as calmness/contentedness (at 600 mg) in healthy adults; supports short‑term mood effects.

  8. Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial

    PubMed ID: 35110300

    IV ketamine RCT produced rapid reductions in severe suicidal ideation and depressive symptoms — strong relevance to acute mood effects.

  9. Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial

    PubMed ID: 35046508

    Repeated ketamine infusions gave rapid antidepressant effects in veterans (antidepressant signal) — relevant to mood support.

  10. Effect of brexanolone on depressive symptoms, anxiety, and insomnia in women with postpartum depression: Pooled analyses from 3 double-blind, randomized, placebo-controlled clinical trials in the HUMMINGBIRD clinical program

    PubMed ID: 36191643

    Brexanolone produced rapid, clinically meaningful improvements in postpartum depression and anxiety — highly relevant to mood support (pharmacologic, not Sage).

  11. Efficacy and safety of esketamine nasal spray by sex in patients with treatment-resistant depression: findings from short-term randomized, controlled trials

    PubMed ID: 34973081

    Esketamine improved depressive symptoms and functioning in TRD; relevant to pharmacologic mood support.

  12. Impact of vortioxetine on depressive symptoms moderated by symptoms of anxiety in persons with post-COVID-19 condition: A secondary analysis

    PubMed ID: 38954891

    Vortioxetine analysis in post‑COVID condition showed depression reduction linked to anxiety improvement — mood‑related finding.

  13. Vortioxetine in children and adolescents with major depressive disorder: 6-month and 18-month open-label, flexible-dose, long-term extension studies

    PubMed ID: 39240359

    Open‑label vortioxetine in children/adolescents associated with symptom improvements — mood improvement but uncontrolled design.

  14. Esketamine Monotherapy in Adults With Treatment-Resistant Depression: A Randomized Clinical Trial

    PubMed ID: 40601310

    Esketamine produced rapid and significant antidepressant effects in TRD — strong direct evidence for mood improvement (pharmacologic).

  15. Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression: a pragmatic, open-label, parallel-group, randomised controlled superiority trial in the UK

    PubMed ID: 40113355

    Quetiapine augmentation reduced long‑term depressive symptom burden more than lithium — relevant clinical mood benefit.

  16. Task-sharing and telemedicine delivery of psychotherapy to treat perinatal depression: a pragmatic, noninferiority randomized trial

    PubMed ID: 40033113

    Behavioral‑activation psychotherapy noninferior to specialists for perinatal depression/anxiety — supports mood treatment via behavioral intervention.

Oral health (10)
  1. The effect of sage (Salvizan gel) compared to triamcinolone acetonide on the treatment of recurrent aphthous stomatitis: a double-blinded randomized clinical trial

    PubMed ID: 36934268

    Randomized double-blind RCT: Salvizan (sage) gel produced faster pain relief and faster complete healing of recurrent aphthous ulcers vs topical steroid — strong direct evidence for oral health benefit.

  2. Clinical evaluation of the effect of a hydrogen peroxide mouth rinse, sodium bicarbonate dentifrice, and mouth moisturizer on oral health

    PubMed ID: 9487836

    Commercial 'Sage' dentifrice (baking-soda brand) produced ~27–30% reduction in gingival inflammation in a clinical trial.

  3. Chlorhexidine swabbing applications under various conditions of use in preventive oral care for persons with disabilities

    PubMed ID: 9002920

    Chlorhexidine swabbing (product by Sage Products) plus cleaning reduced periodontal scores in adults with disabilities.

  4. Oral malodor reduction by a palatal mucoadhesive tablet containing herbal formulation

    PubMed ID: 18468761

    Palatal tablet containing a mixed herbal formulation including sage reduced oral malodor and volatile sulfur compounds vs placebo; multi‑herb formula limits sole attribution to sage but clinical effect present.

  5. Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial

    PubMed ID: 19748859

    Echinacea+sage throat spray markedly reduced sore throat pain and CRP; relevant for upper‑oral/pharyngeal health though echinacea likely contributed.

  6. Results of a randomized controlled phase III trial: efficacy of polyphenol-containing cystus® tea mouthwash solution for the reduction of mucositis in head and neck cancer patients undergoing external beam radiotherapy

    PubMed ID: 32970162

    Randomized small trial directly tested sage tea mouthwash for prevention of radiation‑induced oral mucositis and found performance similar to comparator; directly relevant to oral‑health benefit.

  7. Sage tea-thyme-peppermint hydrosol oral rinse reduces chemotherapy-induced oral mucositis: A randomized controlled pilot study

    PubMed ID: 27515877

    Randomized pilot found sage/thyme/peppermint hydrosol mouth rinse significantly reduced early chemo‑induced oral mucositis (clinically meaningful reduction on day 5); multi‑herb formula and small size limit certainty but this is direct oral‑health evidence.

  8. Efficacy and tolerability of a spray with Salvia officinalis in the treatment of acute pharyngitis - a randomised, double-blind, placebo-controlled study with adaptive design and interim analysis

    PubMed ID: 16504956

    Sage throat spray provided rapid symptomatic relief in viral pharyngitis—relevant to oral/pharyngeal symptom management.

  9. Combined herbal preparation for topical treatment of Herpes labialis

    PubMed ID: 11799306

    Topical sage (and rhubarb–sage) shortened healing time for labial/oral cold sores → direct oral mucosal benefit.

  10. Anti-inflammatory potential of an essential oil-containing mouthwash in elderly subjects enrolled in supportive periodontal therapy: a 6-week randomised controlled clinical trial

    PubMed ID: 31916036

    Randomized trial of a sage-containing mouthwash showed reductions in sulcus bleeding index and plaque index within the test group, though not superior to placebo.

Focus & concentration (7)
  1. Aroma of Genius Essential Oil Blend Significantly Enhances Cognitive Performance and Brain Metabolism in Healthy Adults

    PubMed ID: 41257537

    Study showed reduced arithmetic errors (serial subtraction) and modest cognitive benefits, but immediate word recall was not improved.

  2. Pepinemab antibody blockade of SEMA4D in early Huntington's disease: a randomized, placebo-controlled, phase 2 trial

    PubMed ID: 35941373

    Pepinemab showed exploratory cognitive improvements and reduced caudate atrophy in Huntington’s disease — relevant to memory/focus.

  3. A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age

    PubMed ID: 29433682

    Pilot randomized, double‑blind study of a sage/rosemary/melissa extract demonstrated a large, significant improvement in delayed verbal recall in adults ≤62 (Cohen's d≈0.92) — strongest direct human evidence in this dataset for sage's cognitive/memory effects, though combined‑herb formula and small sample weaken attribution solely to sage.

  4. Lecanemab in patients with early Alzheimer's disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study

    PubMed ID: 36544184

    Lecanemab produced substantial amyloid reduction with modeled slower clinical decline in early Alzheimer's — high relevance to memory and focus outcomes.

  5. The Acute and Chronic Cognitive Effects of a Sage Extract: A Randomized, Placebo Controlled Study in Healthy Humans

    PubMed ID: 33466627

    Primary outcomes in the RCT were improved working‑memory accuracy and increased visuospatial (Corsi) span — direct evidence for memory and focus benefits.

  6. Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery

    PubMed ID: 16205785

    Acute single doses of dried sage leaf improved multitask performance and attention in healthy volunteers (dose‑dependent); supports memory/focus benefits.

  7. Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults

    PubMed ID: 20937617

    Randomized placebo‑controlled crossover human trial with Salvia lavandulaefolia essential oil showed improvements in memory and attention (strongest direct human evidence in dataset).

Respiratory comfort (4)
  1. Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

    PubMed ID: 35151397

    Casirivimab+imdevimab reduced progression/mortality in hospitalized COVID‑19 (a respiratory infectious disease) — relevant to respiratory outcomes via antibody therapy.

  2. Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial

    PubMed ID: 19748859

    Echinacea+sage throat spray was non‑inferior to chlorhexidine/lidocaine for acute sore throat with large pain and CRP reductions; clinical respiratory/upper airway symptom improvement though product combined with echinacea.

  3. Efficacy and tolerability of a spray with Salvia officinalis in the treatment of acute pharyngitis - a randomised, double-blind, placebo-controlled study with adaptive design and interim analysis

    PubMed ID: 16504956

    Randomized double‑blind trial: 15% sage spray reduced throat pain rapidly and was well tolerated in acute viral pharyngitis—strong symptomatic respiratory benefit (upper airway).

  4. Randomized controlled trial for Salvia sclarea or Lavandula angustifolia: differential effects on blood pressure in female patients with urinary incontinence undergoing urodynamic examination

    PubMed ID: 23360656

    Clary sage inhalation significantly reduced respiratory rate in a small human RCT—direct respiratory physiology effect.

Blood circulation (5)
  1. Randomized controlled trial for Salvia sclarea or Lavandula angustifolia: differential effects on blood pressure in female patients with urinary incontinence undergoing urodynamic examination

    PubMed ID: 23360656

    Small RCT: inhaled Salvia sclarea (clary sage) significantly lowered systolic and diastolic blood pressure versus control/lavender (direct human BP effect).

  2. Simvastatin as Add-On Treatment to Escitalopram in Patients With Major Depression and Obesity: A Randomized Clinical Trial

    PubMed ID: 40465256

    Simvastatin produced robust LDL reductions and CRP change — directly relevant to vascular/circulatory risk markers.

  3. High intensity exercise programme in patients with hypertrophic cardiomyopathy: a randomized trial

    PubMed ID: 40037382

    Exercise program improved peak VO2 and reduced SBP — clear cardiovascular/circulation benefit (not sage).

  4. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

    PubMed ID: 35779553

    Tenecteplase vs alteplase stroke trial directly concerns cerebral reperfusion and vascular circulation outcomes — high relevance to circulation support (clinical context, not Sage).

  5. [Effect of point injection of red-sage-root on the hip joint function in ischemic femoral head necrosis patients]

    PubMed ID: 19526810

    Injecting freeze‑dried red sage root (Danshen) into points improved hip pain/function in ischemic femoral head necrosis; Danshen is classically vasoprotective/vasodilatory so results are consistent with circulation benefit, though procedure differs from oral supplement.

Inflammation (4)
  1. [Application of dannang recipe no. 2 in the perioperative stage of laparoscopic cholecystectomy]

    PubMed ID: 19317164

    Perioperative multi‑herb recipe containing red sage reduced inflammatory markers and sped GI recovery after surgery; anti‑inflammatory effect plausible though multi‑herb confounding exists.

  2. [Effect of point injection of red-sage-root on the hip joint function in ischemic femoral head necrosis patients]

    PubMed ID: 19526810

    Danshen (red sage) injections improved pain/function in ischemic bone disease; improvement is consistent with anti‑inflammatory/vascular actions of Danshen in that setting.

  3. Sage extract rich in phenolic diterpenes inhibits ultraviolet-induced erythema in vivo

    PubMed ID: 17713873

    Topical sage extract significantly reduced UV‑induced erythema comparable to 1% hydrocortisone, showing a clear anti‑inflammatory cutaneous effect.

  4. Simvastatin as Add-On Treatment to Escitalopram in Patients With Major Depression and Obesity: A Randomized Clinical Trial

    PubMed ID: 40465256

    Simvastatin lowered CRP versus placebo — direct inflammatory biomarker change relevant to inflammation balance.

Mental clarity (5)
  1. Aroma of Genius Essential Oil Blend Significantly Enhances Cognitive Performance and Brain Metabolism in Healthy Adults

    PubMed ID: 41257537

    Randomized inhaled‑sage aroma produced modest acute increases in alertness and reduced arithmetic errors, supporting short‑term mental clarity.

  2. A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age

    PubMed ID: 29433682

    Pilot RCT of a sage/rosemary/melissa (SRM) extract showed cognitive benefit (delayed verbal recall) in a younger subgroup — suggests clearer cognitive function but study is small and combined herbs limit attribution to sage alone.

  3. Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery

    PubMed ID: 16205785

    Single doses of dried sage leaf improved mood and (at higher dose) multitask performance in healthy adults (placebo‑controlled crossover); acute cognitive/mood benefit plausible.

  4. Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults

    PubMed ID: 20937617

    Randomized crossover single‑dose trial of Salvia lavandulaefolia essential oil improved attention and reduced mental fatigue in healthy adults (direct human cognitive evidence).

  5. The Acute and Chronic Cognitive Effects of a Sage Extract: A Randomized, Placebo Controlled Study in Healthy Humans

    PubMed ID: 33466627

    Randomized double‑blind human trial showed improved attention and working‑memory accuracy and reduced mid‑day attentional decline — consistent with enhanced mental clarity.

Metabolism (4)
  1. Efficacy of Salvia officinalis extract on the prevention of insulin resistance in euglycemic patients with polycystic ovary syndrome: A double-blinded placebo-controlled clinical trial

    PubMed ID: 31987228

    Human randomized, triple-blind trial: Salvia officinalis extract (330 mg/day) for 8 weeks lowered BMI and improved insulin-resistance markers (insulin, HOMA-IR) in women with PCOS — strong direct metabolic evidence in humans (modest sample/short duration).

  2. Antihyperlipidemic effects of Salvia officinalis L. leaf extract in patients with hyperlipidemia: a randomized double-blind placebo-controlled clinical trial

    PubMed ID: 21506190

    Double‑blind RCT of Salvia officinalis leaf extract in hyperlipidemic subjects produced a significant decrease in total cholesterol versus placebo (direct human metabolic evidence).

  3. Amisulpride and olanzapine combination treatment versus each monotherapy in acutely ill patients with schizophrenia in Germany (COMBINE): a double-blind randomised controlled trial

    PubMed ID: 35276079

    Antipsychotic combination caused meaningful metabolic side effects (weight/waist increases) — directly relevant to metabolic balance (adverse example).

  4. Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome - a randomized placebo-controlled clinical trial

    PubMed ID: 40141012

    The PCOS RCT reported a modest but statistically significant reduction in triglycerides versus placebo, supporting a metabolic effect (small sample, short duration).

Immune support (3)
  1. Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

    PubMed ID: 35151397

    Large COVID-19 monoclonal antibody RCT demonstrating improved clinical outcomes via immune-directed therapy (relevant to immune modulation though not about Sage).

  2. [Effect of lixu jieyu recipe in treating 75 patients with chronic fatigue syndrome]

    PubMed ID: 19702080

    Multi-herb decoction containing red sage root improved fatigue and altered T‑cell markers in CFS patients; immune-marker changes observed but multi-herb confounding.

  3. [Clinical effect of yiqi yangyin jiedu decoction in treating patients with advanced non-small cell lung cancer]

    PubMed ID: 18543492

    Multi-herb formula including Chinese sage increased some T‑lymphocyte measures in advanced lung cancer patients; suggests immunomodulatory effect but attribution to sage alone uncertain.

Hormone balance (4)
  1. Efficacy of Salvia officinalis extract on the prevention of insulin resistance in euglycemic patients with polycystic ovary syndrome: A double-blinded placebo-controlled clinical trial

    PubMed ID: 31987228

    PCOS RCT showed improved insulin resistance and BMI — PCOS is hormonally driven and metabolic improvements often reflect hormonal benefit; direct sex-hormone changes were not highlighted in the abstract, so the match is moderate-strong.

  2. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial

    PubMed ID: 22435409

    Topical aromatherapy including clary sage reduced menstrual pain duration (small trial); relevant to menstrual/hormonal symptom comfort though effects were modest and not fully specific.

  3. [Clinical observation on ziyin tongbi decoction in treating benign prostatic hyperplasia]

    PubMed ID: 19317162

    Multi‑herb decoction containing red sage root improved BPH symptom scores though prostate volume unchanged; may reflect symptomatic/hormonal modulation but evidence is indirect.

  4. [Treatment of refractory polycystic ovary syndrome by bushen huoxue method combined with ultrasound-guided follicle aspiration]

    PubMed ID: 18543483

    Multi‑herb recipe including red sage root reduced testosterone and LH/LH‑FSH ratio and increased pregnancy rates in refractory PCOS; indicates hormonal effects in that multi‑herb context.

Vitality (4)
  1. Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery

    PubMed ID: 16205785

    Acute dosing raised alertness and improved performance at higher dose—indicative of short‑term increases in subjective energy/alertness.

  2. Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults

    PubMed ID: 20937617

    Sage essential oil increased alertness and reduced mental fatigue acutely, supporting subjective energy/vitality in the short term.

  3. High intensity exercise programme in patients with hypertrophic cardiomyopathy: a randomized trial

    PubMed ID: 40037382

    High‑intensity exercise increased peak VO2 and fitness — strong direct relevance to energy and vitality.

  4. [Effect of lixu jieyu recipe in treating 75 patients with chronic fatigue syndrome]

    PubMed ID: 19702080

    Multi-herb decoction with red sage root produced greater fatigue improvement in chronic fatigue syndrome patients compared with control; supports energy/vitality benefit in that context.

Wellbeing (3)
  1. Role of multi-component functional foods in the complex treatment of patients with advanced breast cancer

    PubMed ID: 18389773

    Multi-component functional food containing sage reduced oxidative stress markers and improved some QOL subscales in advanced breast cancer patients; overall wellbeing improved but multi‑ingredient confounding exists.

  2. [Effect of lixu jieyu recipe in treating 75 patients with chronic fatigue syndrome]

    PubMed ID: 19702080

    Herbal decoction including red sage root improved fatigue scores in CFS vs control, indicating better perceived wellbeing/energy in a symptomatic population.

  3. High intensity exercise programme in patients with hypertrophic cardiomyopathy: a randomized trial

    PubMed ID: 40037382

    Exercise improved fitness and cardiovascular risk markers — broadly relevant to overall wellbeing.

Antioxidant (3)
  1. Effects of dietary supplementation with sage (Salvia officinalis L.) essential oil on antioxidant status and duodenal wall integrity of laying strain growers

    PubMed ID: 26812815

    Chicken study: sage essential oil increased glutathione peroxidase and decreased MDA (lipid peroxidation) — supports antioxidant activity but in an avian model (indirect for humans).

  2. Role of multi-component functional foods in the complex treatment of patients with advanced breast cancer

    PubMed ID: 18389773

    Multi-component functional food containing sage reduced oxidative stress markers (FORT) in cancer patients; attribution to sage is plausible but confounded by multiple ingredients.

  3. Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome - a randomized placebo-controlled clinical trial

    PubMed ID: 40141012

    Randomized placebo‑controlled trial of Salvia officinalis in women with PCOS showed significant reduction in malondialdehyde (MDA) and some increase in total antioxidant capacity (TAC) — direct evidence of antioxidant activity.

Sleep quality (2)
  1. Efficacy and Safety of Daridorexant in Older and Younger Adults with Insomnia Disorder: A Secondary Analysis of a Randomised Placebo-Controlled Trial

    PubMed ID: 36098936

    Daridorexant analysis in older adults showing improved night-time sleep and daytime functioning — high relevance to sleep quality outcomes.

  2. Safety and efficacy of daridorexant in patients with insomnia disorder: results from two multicentre, randomised, double-blind, placebo-controlled, phase 3 trials

    PubMed ID: 35065036

    Daridorexant RCT showed substantial objective and subjective sleep improvements — directly tests sleep quality (drug study, not Sage).

Digestive support (2)
  1. [Application of dannang recipe no. 2 in the perioperative stage of laparoscopic cholecystectomy]

    PubMed ID: 19317164

    Perioperative multi-herb recipe including red sage markedly sped recovery of gut function (earlier return of bowel sounds, flatus, defecation); strong clinical signal though formula contains multiple herbs.

  2. Effects of dietary supplementation with sage (Salvia officinalis L.) essential oil on antioxidant status and duodenal wall integrity of laying strain growers

    PubMed ID: 26812815

    Chick model showed improved gut barrier measures (TEER) with low-dose sage essential oil, indicating benefit to gut integrity (animal data).

Skin health (2)
  1. Sage extract rich in phenolic diterpenes inhibits ultraviolet-induced erythema in vivo

    PubMed ID: 17713873

    Topical sage extract reduced UV‑induced erythema in healthy volunteers, performing similarly to low‑strength hydrocortisone—direct human evidence for cutaneous anti‑inflammatory benefit.

  2. Combined herbal preparation for topical treatment of Herpes labialis

    PubMed ID: 11799306

    Randomized trial: topical sage (and rhubarb–sage combo) accelerated healing of cold sores vs placebo; direct skin/mucosal benefit.

Similar by evidence

Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.

Products with Sage

Search all

444 products whose verified label declares Sage — not every bottle that mentions it in a title.

Being studied right now

Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.