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Piperine

18 benefits mapped to clinical evidence across supplements.

Dose per serving from products

1,690 products in our catalogue print how much Piperine a serving holds.

Most common: 2.5 mg to 5 mg, 56% of 1,690 products.

Dose per servingProducts
1 mg or less
59
1 mg to 2.5 mg
156
2.5 mg to 5 mg
945
5 mg to 10 mg
363
10 mg to 25 mg
82
25 mg to 50 mg
38
over 50 mg
47

Dose per serving from research

38 study groups in 36 studies say how much Piperine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mg to 5 mg, 39% of 38 study groups.

Daily doseStudy groups
2.5 mg or less
1
2.5 mg to 5 mg
15
5 mg to 10 mg
11
10 mg to 25 mg
8
25 mg to 50 mg
2
over 50 mg
1

See every study group

Commonly used together

36 of 38 study groups took Piperine with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Curcumin
24
Turmeric
4

Benefit Evidence

Metabolism
Moderate

Lipids/glucose ↓

Weight/IR ↓

967 people
Inflammation
Moderate

CRP/TNF-α ↓

PGE2 ↓

769 people
Blood sugar
Moderate

Fasting glucose ↓ ~9-12

HbA1c ↓ ~0.3-0.8%

638 people

ALT/NAFLD ↓

Enzymes ↓ 35.8

ALP/NAFLD ↓

645 people
Heart health
Moderate

Lipids/glucose ↓; HDL ↑

LDL -18 mg/dL

496 people
Antioxidant
Moderate

↓MDA/↑GSH

↑SOD/↓CRP

392 people

Improved breathing symptoms

Marked PAS reduction

93% vs 84%

410 people

Allergy relief, IgE ↓100

Inflammation control, CRP/ESR ↓

256 people

Increased uptake +120%

Reduced ALT -8 U/L

366 people

Weight loss +5.85 kg

Weight maintenance +30%

223 people

Liver detox +10

Metabolic detox markers

288 people

Vitiligo repigmentation + irritation

Hair regrowth, SALT ↓

123 people

Stress/anxiety ↓ -9.4

Depression/anxiety ↓ +serotonin

120 people

PGE2, pain improved

IL-4, IL-6, hs-CRP down

100 people

PGE2↓; pain relief

Inflammation↓, unclear pain

100 people

Sputum conversion +9%

Cure rate +10%

Liver enzymes -6

216 people

Muscle mass +

Cell health +

58 people

Safer swallows −57%

Faster closure 0.380→0.306s

40 people

Research sources

Metabolism (11)
  1. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial

    PubMed ID: 30796508

    Phytosomal curcumin + 8 mg piperine lowered fasting glucose and HOMA-IR in overweight subjects (piperine as adjuvant).

  2. The effect of curcumin-piperine supplementation on lipid profile, glycemic index, inflammation, and blood pressure in patients with type 2 diabetes mellitus and hypertriglyceridemia

    PubMed ID: 39165011

    T2D/high‑TG trial lowered triglycerides and fasting glucose versus placebo.

  3. Effects of Greenselect Phytosome® on weight maintenance after weight loss in obese women: a randomized placebo-controlled study

    PubMed ID: 27450231

    Green-tea extract formulated with piperine helped maintain weight loss and improved metabolic outcomes in obese women (combination product).

  4. Efficacy and safety of Cyperus rotundus extract on weight management in obese individuals: A randomized, double-blind, placebo-controlled study

    PubMed ID: 41305713

    Same trial demonstrated significant triglyceride and BMI improvements, indicating metabolic benefits for the formulation that included piperine; attribution to piperine is uncertain.

  5. Cost-Effectiveness of Passion Fruit Albedo versus Turmeric in the Glycemic and Lipaemic Control of People with Type 2 Diabetes: Randomized Clinical Trial

    PubMed ID: 33141635

    Type 2 diabetes turmeric+piperine RCT reduced HOMA‑IR, triglycerides and improved glycemia (120 days).

  6. The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial

    PubMed ID: 38200253

    Piperine alone improved fasting blood sugar, lowered LDL and reduced ALT in NAFLD/early cirrhosis—direct metabolic effects.

  7. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis

    PubMed ID: 25618800

    Metabolic‑syndrome RCT improved SOD, reduced MDA and lowered CRP — favorable metabolic/inflammatory profile changes.

  8. Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial

    PubMed ID: 25440375

    Curcuminoids+piperine improved multiple lipid parameters in metabolic-syndrome patients (combination evidence for metabolic benefit).

  9. Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects

    PubMed ID: 23271695

    Multi-ingredient supplement containing piperine improved insulin-resistance markers and adrenergic/metabolic biomarkers in overweight subjects.

  10. Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus

    PubMed ID: 29299989

    T2D RCT raised adiponectin and lowered leptin and TNF‑α — beneficial adipokine/inflammatory shifts for metabolic health.

  11. Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial

    PubMed ID: 28735818

    T2D RCT improved atherogenic lipid indices which are closely tied to metabolic syndrome risk.

Inflammation (11)
  1. The effect of curcumin-piperine supplementation on lipid profile, glycemic index, inflammation, and blood pressure in patients with type 2 diabetes mellitus and hypertriglyceridemia

    PubMed ID: 39165011

    T2D/high‑TG RCT reduced triglycerides and fasting glucose and trended to lower CRP — meaningful anti‑inflammatory/metabolic effect.

  2. Effect of curcumin on inflammatory biomarkers and iron profile in patients with premenstrual syndrome and dysmenorrhea: A randomized controlled trial

    PubMed ID: 37394650

    PMS RCT slightly lowered hsCRP vs placebo — modest anti‑inflammatory effect.

  3. Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial

    PubMed ID: 32147075

    NAFLD RCT reduced TNF‑α, MCP‑1 and other inflammatory markers and improved liver imaging.

  4. Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus

    PubMed ID: 29299989

    T2D RCT reduced TNF‑α and improved adipokines, consistent anti‑inflammatory effects with curcumin+piperine.

  5. Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial

    PubMed ID: 25688638

    Knee OA RCT produced antioxidant marker improvements and lowered MDA, reflecting reduced oxidative inflammation.

  6. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis

    PubMed ID: 25618800

    Metabolic‑syndrome RCT showed CRP reduction alongside antioxidant improvements — robust anti‑inflammatory signal.

  7. Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery

    PubMed ID: 38901949

    Curcumin+piperine modestly lowered CRP perioperatively and increased TAC (anti-inflammatory/antioxidant biomarker changes).

  8. Herbal formulation "turmeric extract, black pepper, and ginger" versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial

    PubMed ID: 32180294

    Turmeric/black pepper/ginger reduced PGE2, a key inflammatory mediator, in osteoarthritis patients (multi-herbal product including piperine source).

  9. Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial

    PubMed ID: 37378780

    Curcumin+piperine in ICU COVID patients reduced CRP (inflammatory marker) over 7 days (combination product, small sample).

  10. Therapeutic effects of curcumin and piperine combination in critically ill patients with sepsis: a randomized double-blind controlled trial

    PubMed ID: 40514680

    Septic ICU RCT had large CRP and ESR reductions over 7 days — strong anti‑inflammatory effect in acute setting.

  11. The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial

    PubMed ID: 38082237

    Stroke rehab RCT reported multiple inflammatory reductions including hs‑CRP alongside cardiometabolic improvements.

Blood sugar (8)
  1. Cost-Effectiveness of Passion Fruit Albedo versus Turmeric in the Glycemic and Lipaemic Control of People with Type 2 Diabetes: Randomized Clinical Trial

    PubMed ID: 33141635

    T2D RCT (turmeric+piperine) reduced HOMA‑IR and improved fasting glycemia and HbA1c over 120 days.

  2. Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial

    PubMed ID: 29458218

    Curcuminoids + 5 mg piperine reduced fasting glucose and C-peptide modestly in T2D after 3 months (combination product).

  3. The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial

    PubMed ID: 38200253

    Piperine alone lowered fasting blood sugar in NAFLD/early cirrhosis patients (direct clinical glucose-lowering effect).

  4. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial

    PubMed ID: 30796508

    Phytosomal curcumin + piperine reduced fasting plasma glucose and HOMA-IR in overweight subjects (piperine present as enhancer).

  5. Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects

    PubMed ID: 23271695

    Multi-ingredient supplement including piperine improved HOMA and insulin-resistance markers (metabolic/blood-sugar relevance).

  6. The Effects of Curcumin Plus Piperine Supplementation in Patients with Acute Myocardial Infarction: A Randomized, Double-Blind, and Placebo-Controlled Trial

    PubMed ID: 34981479

    Acute MI RCT found HbA1c improvement with curcumin+piperine adjunct therapy.

  7. The effect of curcumin-piperine supplementation on lipid profile, glycemic index, inflammation, and blood pressure in patients with type 2 diabetes mellitus and hypertriglyceridemia

    PubMed ID: 39165011

    T2D with high TG trial showed significant reductions in fasting blood glucose with curcumin+piperine.

  8. Effectiveness of the piperine-supplemented Curcuma longa L. in metabolic control of patients with type 2 diabetes: a randomised double-blind placebo-controlled clinical trial

    PubMed ID: 33586583

    Curcuma longa with piperine improved blood sugar control and triglycerides in T2D over 120 days (combination product evidence).

Liver support (7)
  1. The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial

    PubMed ID: 38200253

    Piperine alone (5 mg/day) substantially decreased ALT in NAFLD/early cirrhosis patients—strong direct liver-support signal.

  2. A Randomized, Controlled, Phase III Clinical Trial to Evaluate the Efficacy and Tolerability of Risorine with Conventional Rifampicin in the Treatment of Newly Diagnosed Pulmonary Tuberculosis Patients

    PubMed ID: 29313577

    Rifampicin+piperine formulation (Risorine) reduced liver enzyme elevations versus standard therapy in pulmonary TB — protective hepatic signal.

  3. The Effects of Curcumin Plus Piperine Supplementation in Patients with Acute Myocardial Infarction: A Randomized, Double-Blind, and Placebo-Controlled Trial

    PubMed ID: 34981479

    AMI RCT observed ALT reductions with curcumin+piperine adjunct — improved liver enzyme profile.

  4. Curcumin and Piperine Combination for the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind Randomized Placebo-Controlled Trial

    PubMed ID: 34981468

    NAFLD RCT: curcumin+piperine modestly lowered ALP and improved ultrasound fatty‑liver severity.

  5. Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial

    PubMed ID: 31168845

    Curcumin with piperine improved NAFLD severity and ALT vs placebo (combination product evidence).

  6. Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized, placebo-controlled clinical trial

    PubMed ID: 36799355

    12-week curcumin+piperine improved fasting glucose, ALT and lipids in patients with hepatic steatosis (combination effect).

  7. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial

    PubMed ID: 30796508

    Phytosomal curcumin + piperine decreased GPT/ALT in overweight subjects (piperine included as bioenhancer).

Heart health (6)
  1. The Effects of Curcumin Plus Piperine Supplementation in Patients with Acute Myocardial Infarction: A Randomized, Double-Blind, and Placebo-Controlled Trial

    PubMed ID: 34981479

    Acute MI RCT showed improved LDL/HDL and HbA1c and reduced ALT — cardiometabolic benefits with curcumin+piperine adjunct.

  2. Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial

    PubMed ID: 28735818

    T2D RCT reported significant improvements in total/non‑HDL cholesterol, Lp(a) and a small HDL increase with curcumin+piperine.

  3. Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial

    PubMed ID: 25440375

    Curcuminoids with piperine improved LDL, non-HDL, TG and HDL in metabolic-syndrome patients (cardiometabolic lipid profile benefits).

  4. The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial

    PubMed ID: 38200253

    Piperine alone (5 mg/day) lowered LDL in NAFLD/early cirrhosis patients (direct lipid benefit from piperine trial).

  5. The effect of curcumin-piperine supplementation on lipid profile, glycemic index, inflammation, and blood pressure in patients with type 2 diabetes mellitus and hypertriglyceridemia

    PubMed ID: 39165011

    T2D with high TG trial reduced triglycerides and fasting glucose, relevant to heart disease risk management.

  6. The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial

    PubMed ID: 38082237

    Stroke rehab RCT reduced triglycerides and systolic BP alongside CRP reductions (cardiometabolic signals).

Antioxidant (5)
  1. Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery

    PubMed ID: 38901949

    Curcumin+piperine perioperative regimen raised total antioxidant capacity vs placebo (modest evidence, combination product).

  2. Therapeutic effects of curcumin and piperine combination in critically ill patients with sepsis: a randomized double-blind controlled trial

    PubMed ID: 40514680

    Septic ICU RCT produced large CRP/ESR reductions, consistent with reduced oxidative/inflammatory burden.

  3. Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial

    PubMed ID: 25688638

    Knee OA RCT reported significant increases in SOD and reductions in MDA with curcumin+piperine.

  4. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis

    PubMed ID: 25618800

    Metabolic‑syndrome RCT showed increased SOD and decreased MDA (clear antioxidant improvements with curcuminoids+piperine).

  5. Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial

    PubMed ID: 25171552

    Curcumin+piperine RCT showed clear increases in GSH and decreases in MDA — strong antioxidant biomarker effects.

Respiratory comfort (4)
  1. A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy

    PubMed ID: 39121267

    Nigella sativa oil capsules containing piperine reduced nasal/ocular allergy scores and IgE—clinical respiratory/allergic benefit.

  2. A Randomized, Controlled, Phase III Clinical Trial to Evaluate the Efficacy and Tolerability of Risorine with Conventional Rifampicin in the Treatment of Newly Diagnosed Pulmonary Tuberculosis Patients

    PubMed ID: 29313577

    Risorine (rifampicin+piperine) improved early sputum conversion and cure rates in pulmonary TB — direct antimicrobial respiratory benefit.

  3. Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial

    PubMed ID: 25171552

    Chronic sulfur‑mustard lung injury trial: curcumin+piperine improved respiratory symptoms and quality‑of‑life (SGRQ, CAT).

  4. Effect of oral piperine on the swallow response of patients with oropharyngeal dysphagia

    PubMed ID: 24326980

    Oral piperine bolus markedly reduced unsafe swallows and shortened LVC time, lowering aspiration risk relevant to respiratory protection.

Immune support (4)
  1. A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy

    PubMed ID: 39121267

    Nigella sativa oil capsules containing piperine lowered serum IgE and allergy scores—immuno-modulatory clinical effect in allergic patients.

  2. Effects of curcumin-piperine supplementation on systemic immunity in young women with premenstrual syndrome and dysmenorrhea: A randomized clinical trial

    PubMed ID: 36174434

    PMS/dysmenorrhea RCT showed reduced serum IgE with curcumin+piperine, suggesting modulation of allergic/immune markers.

  3. Therapeutic effects of curcumin and piperine combination in critically ill patients with sepsis: a randomized double-blind controlled trial

    PubMed ID: 40514680

    Septic ICU RCT markedly reduced CRP/ESR and altered counts — clinically relevant immune/inflammatory effects.

  4. Randomised Clinical Trial Study: The Combination of Vitamin D and Curcumin Piperine Attenuates Disease Activity and Pro-inflammatory Cytokines Levels Insystemic Lupus Erythematosus Patients

    PubMed ID: 38299416

    SLE RCT: curcumin+piperine (with vitamin D) reduced disease activity and IL‑6, indicating immune‑modulatory effects.

Nutrient uptake (3)
  1. Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial

    PubMed ID: 31168845

    Curcumin co-administered with piperine improved liver/NAFLD endpoints—piperine used as bioenhancer; supports piperine's role increasing bioavailability in combination products.

  2. A Randomized, Controlled, Phase III Clinical Trial to Evaluate the Efficacy and Tolerability of Risorine with Conventional Rifampicin in the Treatment of Newly Diagnosed Pulmonary Tuberculosis Patients

    PubMed ID: 29313577

    Risorine (rifampicin+piperine) demonstrated improved clinical outcomes (earlier sputum conversion) and fewer liver enzyme rises — classic evidence of piperine acting as bioenhancer for a co‑drug.

  3. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial

    PubMed ID: 30796508

    Phytosomal curcumin products often include piperine to boost curcumin exposure; clinical metabolic effects imply enhanced bioavailability though piperine not isolated.

Weight management (3)
  1. Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects

    PubMed ID: 23271695

    Multi-ingredient supplement with piperine altered metabolic and adrenergic markers and RQ favorably—consistent with weight-management mechanisms.

  2. Efficacy and safety of Cyperus rotundus extract on weight management in obese individuals: A randomized, double-blind, placebo-controlled study

    PubMed ID: 41305713

    Randomized trial of a Cyperus rotundus formulation containing piperine showed significantly greater weight and BMI reduction vs placebo over 90 days; effect is real but multi‑component product confounds attribution to piperine alone.

  3. Effects of Greenselect Phytosome® on weight maintenance after weight loss in obese women: a randomized placebo-controlled study

    PubMed ID: 27450231

    Greenselect Phytosome containing piperine improved weight-loss maintenance vs placebo (clear clinical weight-management result for the formulation).

Detoxification (2)
  1. A Randomized, Controlled, Phase III Clinical Trial to Evaluate the Efficacy and Tolerability of Risorine with Conventional Rifampicin in the Treatment of Newly Diagnosed Pulmonary Tuberculosis Patients

    PubMed ID: 29313577

    Risorine reduced liver enzyme elevations vs control during TB therapy, suggesting protective/detoxification‑related hepatic effects when piperine is used to enhance therapy.

  2. The Effects of Curcumin Plus Piperine Supplementation in Patients with Acute Myocardial Infarction: A Randomized, Double-Blind, and Placebo-Controlled Trial

    PubMed ID: 34981479

    AMI RCT showed ALT reductions with curcumin+piperine — improved liver enzyme profile consistent with detoxification support.

Skin health (2)
  1. Efficacy of a mixed preparation containing piperine, capsaicin and curcumin in the treatment of alopecia areata

    PubMed ID: 35318791

    Topical multi-agent prep that included piperine produced hair regrowth in alopecia areata comparable to minoxidil (piperine part of topical formulation).

  2. The effect of topical piperine combined with narrowband UVB on vitiligo treatment: A clinical trial study

    PubMed ID: 29781089

    Topical piperine + NB-UVB produced significantly greater facial vitiligo repigmentation than NB-UVB alone (direct, local piperine effect).

Mood balance (2)
  1. A Standardized Withania somnifera (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study

    PubMed ID: 37878284

    Ashwagandha + piperine for 90 days improved depression and anxiety scores and increased serum serotonin (clinical mood benefits with piperine included).

  2. A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study

    PubMed ID: 37832082

    Ashwagandha tablets formulated with 5 mg piperine reduced perceived stress, anxiety and morning cortisol vs placebo (piperine present as adjuvant).

Joint comfort (2)
  1. Herbal formulation "turmeric extract, black pepper, and ginger" versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial

    PubMed ID: 32180294

    Turmeric+black pepper+ginger reduced PGE2 and improved knee OA symptoms similar to naproxen (black pepper is piperine source).

  2. Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial

    PubMed ID: 25050518

    Knee OA RCT reported clinical symptom improvements with curcumin+piperine though systemic biomarker between‑group differences were inconclusive.

Pain relief (2)
  1. Herbal formulation "turmeric extract, black pepper, and ginger" versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial

    PubMed ID: 32180294

    Herbal formulation including black pepper reduced knee OA pain similarly to naproxen over 4 weeks (clinical analgesic effect in combination product).

  2. Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial

    PubMed ID: 25050518

    Knee OA study reported clinical symptom improvement with curcumin+piperine despite ambiguous systemic biomarker changes — supports modest pain relief.

Antimicrobial (1)
  1. A Randomized, Controlled, Phase III Clinical Trial to Evaluate the Efficacy and Tolerability of Risorine with Conventional Rifampicin in the Treatment of Newly Diagnosed Pulmonary Tuberculosis Patients

    PubMed ID: 29313577

    Large RCT: rifampicin+piperine (Risorine) improved early sputum conversion and cure rates in pulmonary TB — direct antimicrobial adjunct benefit.

Healthy aging (1)
  1. Curcumin plus piperine improve body composition in patients with inflammatory bowel disease: a randomized, double-blind, placebo-controlled clinical trial

    PubMed ID: 39934549

    IBD RCT increased fat‑free mass and phase angle (cellular health) — signals relevant to healthy aging and preservation of lean mass.

Digestive support (1)
  1. Effect of oral piperine on the swallow response of patients with oropharyngeal dysphagia

    PubMed ID: 24326980

    Direct piperine bolus administration in dysphagic patients markedly reduced unsafe swallows and shortened LVC time—strong digestive/bolus-safety effect.

Similar by evidence

Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.

Products with Piperine

Search all

2260 products whose verified label declares Piperine — not every bottle that mentions it in a title.

Being studied right now

Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.