Manganese
14 benefits mapped to clinical evidence across supplements.
Dose per serving from products
8,990 products in our catalogue print how much Manganese a serving holds.
Most common: 1 mg to 2.5 mg, 39% of 8,990 products.
| Dose per serving | Products |
|---|---|
| 100 mcg or less | 432 |
| 100 mcg to 250 mcg | 439 |
| 250 mcg to 500 mcg | 1,067 |
| 500 mcg to 1 mg | 1,453 |
| 1 mg to 2.5 mg | 3,506 |
| 2.5 mg to 5 mg | 1,414 |
| 5 mg to 10 mg | 449 |
| over 10 mg | 230 |
Dose per serving from research
13 study groups in 10 studies say how much Manganese participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mg to 5 mg and 1 g to 2.5 g, 31% of 13 study groups each.
| Daily dose | Study groups |
|---|---|
| 2.5 mg or less | 1 |
| 2.5 mg to 5 mg | 4 |
| 5 mg to 10 mg | 0 |
| 10 mg to 25 mg | 0 |
| 25 mg to 50 mg | 0 |
| 50 mg to 100 mg | 0 |
| 100 mg to 250 mg | 1 |
| 250 mg to 500 mg | 1 |
| 500 mg to 1 g | 2 |
| 1 g to 2.5 g | 4 |
Commonly used together
8 of 13 study groups took Manganese with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Zinc | 5 |
| Copper | 4 |
| Vitamin C | 3 |
Benefit Evidence
+1.1% laying rate
better litter/hatchability
sperm integrity: dose-sensitive
Research sources
Antioxidant (10)
- Ginkgo biloba for Tardive Dyskinesia and Plasma MnSOD Activity: Association with MnSOD Ala-9Val Variant: A Randomized, Double-blind Trial
PubMed ID: 38919004
Randomized trial: Ginkgo improved dyskinesia and increased MnSOD activity, implicating MnSOD-mediated antioxidant effects.
- Effect of manganese supplementation and source on carcass traits, meat quality, and lipid oxidation in broilers
PubMed ID: 17040939
Dietary Mn in broilers increased MnSOD expression/activity and decreased MDA (lipid oxidation) — direct antioxidant biomarker changes.
- Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer
PubMed ID: 31618127
Avasopasem manganese is an Mn-containing SOD‑mimetic that produced large clinical reductions in radiation mucositis via antioxidant mechanism.
- Impact of dietary manganese concentration on status criteria to determine manganese requirement in piglets
PubMed ID: 21883497
Weaned piglets showed Mn-dependent increases in MnSOD and other enzyme activities with dietary Mn — supports antioxidant enzyme activation.
- Dietary curcumin supplementation protects against heat-stress-impaired growth performance of broilers possibly through a mitochondrial pathway
PubMed ID: 26020187
Curcumin raised Mn-dependent SOD activity (biomarker) in broilers — direct Mn-SOD antioxidant signal (animal model).
- Recombinant human manganese superoxide dismutase attenuates early but not delayed skeletal muscle dysfunction following reperfusion injury
PubMed ID: 10480957
Recombinant MnSOD reduced reperfusion oxidative muscle injury in rats, demonstrating direct antioxidant protection.
- [Effect of buxu huayu qutan decoction on anti-oxidative capacity in aged patients with stable angina pectoris of coronary heart disease]
PubMed ID: 19848199
Human study of herbal treatment increased plasma SOD activity and MnSOD mRNA; manganese attribution indirect but MnSOD pathway implicated.
- Effect of Waon therapy on oxidative stress in chronic heart failure
PubMed ID: 21173495
Far‑infrared therapy reduced oxidative markers in heart failure patients and upregulated MnSOD in animals—links to MnSOD antioxidant pathway.
- The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury
PubMed ID: 38215546
Manganese SOD-mimetic (avasopasem) strongly reduced oxidative injury in preclinical models and reduced AKI signals in patients—direct antioxidant mechanism.
- Persistent prevention of oxaliplatin-induced peripheral neuropathy using calmangafodipir (PledOx(®)): a placebo-controlled randomised phase II study (PLIANT)
PubMed ID: 29140155
Calmangafodipir (Mn-based SOD-mimetic) reduced neuropathy symptoms—translational antioxidant mechanism.
Joints & tendons (6)
- Bioefficacy comparison of organic manganese with inorganic manganese for eggshell quality in Hy-Line Brown laying hens
PubMed ID: 26047673
Organic Mn greatly improved eggshell mechanical properties (thickness/strength) in hens — supportive of Mn's role in mineralized connective/structural tissue formation (animal model).
- Effect of inorganic and organic manganese supplementation on the performance and tissue manganese content of broiler chicks
PubMed ID: 15168751
Animal study showed dose‑dependent Mn accumulation in tibia (bone) and tissues; supports Mn’s role in skeletal/connective tissue mineralization.
- Productive performance, eggshell quality, and eggshell ultrastructure of laying hens fed diets supplemented with organic trace minerals
PubMed ID: 24570429
Supplemental Mn (with Zn/Cu) improved shell matrix formation and strength (structural connective tissue analogue in poultry).
- Effect of dietary nutrients on osteochondrosis lesions and cartilage properties in pigs
PubMed ID: 18447792
Pig diets supplemented with minerals including Mn yielded significantly lower osteochondrosis lesion severity — strong cartilage support signal (animal).
- Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study
PubMed ID: 10050562
Glucosamine/chondroitin/manganese‑ascorbate combo reduced OA symptoms; plausible cartilage support though Mn's independent effect not isolated.
- Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis
PubMed ID: 10966840
RCT showed ISK improvement with the combination product including Mn — supports cartilage symptom improvement (multi‑ingredient confounded).
Cell health (5)
- Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer
PubMed ID: 31618127
Avasopasem (Mn SOD‑mimetic) produced clinical tissue protection (mucositis) and acts at cellular oxidative stress pathways.
- Impact of dietary manganese concentration on status criteria to determine manganese requirement in piglets
PubMed ID: 21883497
Dietary Mn normalized Mn‑dependent enzyme activities in piglets and increased tissue Mn — direct cellular biomarker effects in animals.
- Effect of manganese supplementation and source on carcass traits, meat quality, and lipid oxidation in broilers
PubMed ID: 17040939
Increased MnSOD activity/mRNA and decreased lipid peroxidation in broilers indicate improved cellular antioxidant defenses with dietary Mn.
- Persistent prevention of oxaliplatin-induced peripheral neuropathy using calmangafodipir (PledOx(®)): a placebo-controlled randomised phase II study (PLIANT)
PubMed ID: 29140155
Calmangafodipir reduced neuropathy symptoms and is an Mn-based SOD-mimetic protecting neural cells from oxidative damage.
- The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury
PubMed ID: 38215546
Avasopasem mitigated cisplatin-induced kidney injury and lowered injury biomarkers—evidence of cellular protection via Mn SOD-mimetic.
Nerve health (5)
- The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury
PubMed ID: 38215546
Avasopasem (Mn SOD-mimetic) reduced oxidative injury in mice and reduced AKI signals in trials; mechanism (ROS mitigation) is neuroprotective in principle though trial endpoints were renal.
- Late motor deficits of Chilean manganese miners: a blinded control study
PubMed ID: 8797481
Long-term follow-up of Mn-exposed miners showed persistent tremor and motor deficits—strong evidence of Mn-related neurotoxicity (adverse to nervous system health).
- Ginkgo biloba for Tardive Dyskinesia and Plasma MnSOD Activity: Association with MnSOD Ala-9Val Variant: A Randomized, Double-blind Trial
PubMed ID: 38919004
Ginkgo improved involuntary movements and increased MnSOD activity—clinically relevant neuromotor improvement connected to MnSOD activity.
- Persistent prevention of oxaliplatin-induced peripheral neuropathy using calmangafodipir (PledOx(®)): a placebo-controlled randomised phase II study (PLIANT)
PubMed ID: 29140155
Calmangafodipir (Mn-based SOD-mimetic) reduced acute and chronic neuropathy in cancer patients—strong neuroprotective signal.
- Motor function, olfactory threshold, and hematological indices in manganese-exposed ferroalloy workers
PubMed ID: 9311544
Occupational exposure correlated with worse psychomotor performance—supports Mn’s impact on nervous system function (adverse).
Fertility (4)
- Changes in blood manganese levels during pregnancy in iron supplemented and non supplemented women
PubMed ID: 8846152
Pregnancy study documented progressive rises in maternal blood manganese across trimesters—direct relevance to maternal/fetal Mn exposure dynamics.
- Effect of supplementation of organic manganese on reproductive performance of female Ussuri raccoon dogs (Nyctereutes procyonoides) during the breeding season
PubMed ID: 25082102
Raccoon dog study: 120 mg/kg organic Mn increased litter size and pups born/weaned — direct reproductive benefit in an animal model.
- Effect of manganese supplementation on the membrane integrity and the mitochondrial potential of the sperm of grazing Nelore bulls
PubMed ID: 25216627
Nelore bull trial showed dose‑dependent effects on sperm integrity with low Mn improving sperm and high doses harming it — clear reproductive dose‑response in animals.
- Effect of amount and source of manganese and/or phytase supplementation on productive and reproductive performance and some physiological traits of dual purpose cross-bred hens in the tropics
PubMed ID: 20461585
Large poultry trial: modest added Mn improved hatchability, egg traits, and sperm quality — strong animal evidence for reproductive benefits.
Brain health (4)
- Ginkgo biloba for Tardive Dyskinesia and Plasma MnSOD Activity: Association with MnSOD Ala-9Val Variant: A Randomized, Double-blind Trial
PubMed ID: 38919004
Randomized trial showed clinical improvement in involuntary movements and increased MnSOD activity—direct brain/neuromotor benefit (via MnSOD pathway).
- Late motor deficits of Chilean manganese miners: a blinded control study
PubMed ID: 8797481
Former manganese‑exposed miners had lasting motor dysfunction—strong evidence that manganese exposure affects brain/motor systems (adverse).
- Motor function in adults of an Ohio community with environmental manganese exposure
PubMed ID: 21840336
Residents near an Mn smelter had subtle increases in motor signs and postural sway — clear human evidence that Mn exposure affects brain/motor function (adverse).
- Persistent prevention of oxaliplatin-induced peripheral neuropathy using calmangafodipir (PledOx(®)): a placebo-controlled randomised phase II study (PLIANT)
PubMed ID: 29140155
Calmangafodipir reduced chemotherapy-induced neuropathic symptoms—neuroprotective effect relevant to nervous system/brain function.
Bone health (3)
- Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals
PubMed ID: 8027856
2‑yr RCT in postmenopausal women: calcium + trace minerals (including Mn) increased spinal BMD vs placebo; clinically relevant though multi‑element confounding.
- Bioefficacy comparison of organic manganese with inorganic manganese for eggshell quality in Hy-Line Brown laying hens
PubMed ID: 26047673
Organic Mn markedly improved eggshell thickness and breaking strength (animal model) — supports Mn role in mineralized structure strength.
- Effect of inorganic and organic manganese supplementation on the performance and tissue manganese content of broiler chicks
PubMed ID: 15168751
Broiler chick feeding: clear, dose-dependent Mn accumulation in tibia (bone) indicating a role in bone Mn status—direct tissue evidence.
Joint comfort (3)
- Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis
PubMed ID: 10966840
Larger RCT showing symptomatic improvement in mild–moderate knee OA with glucosamine/chondroitin/manganese‑ascorbate; strong clinical effect but confounded by other agents.
- Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study
PubMed ID: 10050562
Small RCT: glucosamine+chondroitin+manganese‑ascorbate reduced knee OA pain and exam scores; good clinical signal but Mn was part of a multi‑ingredient product.
- Effect of dietary nutrients on osteochondrosis lesions and cartilage properties in pigs
PubMed ID: 18447792
Pigs fed diets with added minerals including Mn had less severe osteochondrosis/cartilage growth‑plate lesions — direct cartilage/joint benefit (animal).
Digestive support (2)
- Manganese superoxide dismutase polymorphism and risk of gastric lesions, and its effects on chemoprevention in a Chinese population
PubMed ID: 20233853
Large genetic study linking MnSOD variant to advanced gastric lesions—strong relevance to gastric/digestive pathology (MnSOD pathway involvement).
- Manganese intake and cholestatic jaundice in neonates receiving parenteral nutrition: a randomized controlled study
PubMed ID: 11683188
Clinical signal in infants on long‑term parenteral nutrition: higher Mn dosing increased blood Mn and was associated with jaundice/cholestasis (digestive/hepatic adverse effect).
Immune support (2)
- Supplementing Zn, Mn, and Cu from amino acid complexes and Co from cobalt glucoheptonate during the peripartal period benefits postpartal cow performance and blood neutrophil function
PubMed ID: 26723127
Switching to more bioavailable trace minerals (including Mn) improved neutrophil phagocytosis and antioxidant capacity postpartum in cows.
- Effects of injectable trace minerals on humoral and cell-mediated immune responses to Bovine viral diarrhea virus, Bovine herpes virus 1 and Bovine respiratory syncytial virus following administration of a modified-live virus vaccine in dairy calves
PubMed ID: 27496747
Injectable trace minerals including Mn boosted antibody titers, PBMC proliferation and IFN‑γ in calves — clear immune enhancement (animal, multi‑mineral).
Metabolism (1)
- Effect of manganese supplementation and source on carcass traits, meat quality, and lipid oxidation in broilers
PubMed ID: 17040939
Dietary Mn in broilers decreased abdominal fat and increased MnSOD and related metabolic markers — indicates metabolic effects in animals.
Skin health (1)
- Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer
PubMed ID: 31618127
Avasopasem manganese markedly reduced severe oral mucositis (mucosal/skin‑like tissue injury) — relevant to tissue/skin health and healing.
Skin repair (1)
- Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer
PubMed ID: 31618127
Avasopasem manganese substantially reduced incidence/duration of severe oral mucositis (a mucosal/wound healing endpoint) in a large RCT.
Growth support (1)
- Nutrition of very low birth weight infants fed human milk with or without supplemental trace elements: a randomized controlled trial
PubMed ID: 15448423
Fortifying human milk increased Mn intake in very low birth weight infants — most directly relevant to infant nutrient/growth support among the listed studies.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Manganese
Search all10597 products whose verified label declares Manganese — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.