| Coffee Abundant in Chlorogenic Acids Reduces Abdominal Fat in Overweight Adults: A Randomized, Double-Blind, Controlled Trial 2019 · CGA coffee-consuming group · Healthy overweight men and women aged 20 to under 65 years, with BMI 25 to under 30 kg/m² and visceral fat area at least 80 cm² | 369 mg | 12 weeks | 72 |
| Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial 2020 · CGA group · Healthy women aged 40–59 years with menopausal symptoms, including subjective hot flushes | 270 mg | 4 weeks | 39 |
| Helianthus annuus Seed Extract Affects Weight and Body Composition of Healthy Obese Adults during 12 Weeks of Consumption: A Randomized, Double-Blind, Placebo-Controlled Pilot Study 2019 · sunflower extract group · Adults aged 18–65 of both sexes with obesity (BMI 30–40 kg/m²) | 500 mg | 12 weeks | 30 |
| A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-Obesity: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study 2023 · Altilix group · Adults with pre-obesity (BMI ≥25 and <30 kg/m²) and at least three altered cardiometabolic parameters | 150 mg | 26 weeks | 28 |
| Effect of Chlorogenic Acids on Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial 2018 · CGA group · Healthy adults aged 50–69 years with subjective memory complaints | 300 mg | 16 weeks | 20 |
| Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension 2019 · Study 1, Beverage A · Adults aged 30 years or older with borderline or stage 1 hypertension; men and women | 412 mg | 1 day | 19 |
| Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension 2019 · Study 1, Beverage B · Adults aged 30 years or older with borderline or stage 1 hypertension; men and women | 378 mg | 1 day | 19 |
| Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension 2019 · Study 2, Beverage A · Adults aged 30 years or older with borderline or stage 1 hypertension; men and women | 412 mg | 1 day | 18 |
| Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women 2016 · 450 mg purified 5-CGA · Healthy men and women | 450 mg | 1 day | 16 |
| Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women 2016 · 900 mg purified 5-CGA · Healthy men and women | 900 mg | 1 day | 16 |
| Effects of Chlorogenic Acid-Enriched and Hydroxyhydroquinone-Reduced Coffee on Postprandial Fat Oxidation and Antioxidative Capacity in Healthy Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial 2018 · CGA-HHQ(−) · Healthy men aged 20–60 years with BMI 20.0–29.9 kg/m² | 428 mg | 4 weeks | 15 |
| Effects of Chlorogenic Acid-Enriched and Hydroxyhydroquinone-Reduced Coffee on Postprandial Fat Oxidation and Antioxidative Capacity in Healthy Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial 2018 · CGA-HHQ(+) · Healthy men aged 20–60 years with BMI 20.0–29.9 kg/m² | 382 mg | 4 weeks | 15 |
| Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials 2017 · 5-CQA 450 mg · healthy adult men; age not stated | 450 mg | 1 day | — |
| Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials 2017 · 5-CQA 900 mg · healthy adult men; age not stated | 900 mg | 1 day | — |
| Effects of subacute ingestion of chlorogenic acids on sleep architecture and energy metabolism through activity of the autonomic nervous system: a randomised, placebo-controlled, double-blinded cross-over trial 2017 · 600 mg CGA beverage · Healthy adult men and women; age not reported | 600 mg | 5 days | — |
| The acute effect of coffee on endothelial function and glucose metabolism following a glucose load in healthy human volunteers 2017 · caffeinated coffee · healthy men and women; ages and sex-specific numbers not reported | 600 mg | 1 day | — |
| The acute effect of coffee on endothelial function and glucose metabolism following a glucose load in healthy human volunteers 2017 · decaffeinated coffee · healthy men and women; ages and sex-specific numbers not reported | 574 mg | 1 day | — |
| Acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial 2021 · Dose 1 (302 mg DGCE) · Healthy men and postmenopausal women aged 45–65 years with screening FMD below 7.5% and suboptimal endothelial function | 156 mg | 1 day | 21 |
| Acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial 2021 · Dose 2 (604 mg DGCE) · Healthy men and postmenopausal women aged 45–65 years with screening FMD below 7.5% and suboptimal endothelial function | 313 mg | 1 day | 21 |
| Acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial 2021 · Dose 3 (906 mg DGCE) · Healthy men and postmenopausal women aged 45–65 years with screening FMD below 7.5% and suboptimal endothelial function | 440 mg | 1 day | 21 |
| Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials 2017 · coffee with 89 mg CGA · healthy adult men; age not stated | 89 mg | 1 day | — |
| Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials 2017 · coffee with 310 mg CGA · healthy adult men; age not stated | 310 mg | 1 day | — |
| Consumption of a Coffee Rich in Phenolic Compounds May Improve the Body Composition of People with Overweight or Obesity: Preliminary Insights from a Randomized, Controlled and Blind Crossover Study 2024 · Lightly roasted coffee (LRC) · Adults aged 18–65 with overweight or obesity (BMI 25.0–35.0 kg/m²) | 1.2 g | 12 weeks | — |
| Consumption of a Coffee Rich in Phenolic Compounds May Improve the Body Composition of People with Overweight or Obesity: Preliminary Insights from a Randomized, Controlled and Blind Crossover Study 2024 · Commercial roasted coffee (RC) · Adults aged 18–65 with overweight or obesity (BMI 25.0–35.0 kg/m²) | 450 mg | 12 weeks | — |
| Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial 2012 · chlorogenic acid · Healthy men and women; no age range reported | 400 mg | 1 day | 23 |
| The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension 2006 · CGA group · People with mild hypertension; age and sex not reported | 140 mg | — | — |
| A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans 2020 · Coffee berry extract beverage · Healthy adults aged 18–35 years, males and females | 440 mg | 1 day | 32 |
| Moderate consumption of a soluble green/roasted coffee rich in caffeoylquinic acids reduces cardiovascular risk markers: results from a randomized, cross-over, controlled trial in healthy and hypercholesterolemic subjects 2019 · soluble green/roasted coffee · Adults: 25 normocholesterolemic and 27 moderately hypercholesterolemic subjects; age and sex not stated | 6 g | 8 weeks | 52 |
| Effects of the Consumption of Low-Fat Cooked Ham with Reduced Salt Enriched with Antioxidants on the Improvement of Cardiovascular Health: A Randomized Clinical Trial 2021 · experimental group (EXP) · Adults aged 30–75 years, both sexes, with LDL-C ≥110 mg/dL or total cholesterol ≥180 mg/dL and BMI 20–32 kg/m², without pharmacological treatment | 22.5 mg | 8 weeks | 36 |
| Changes in the plasma lipidome of healthy subjects after coffee consumption reveal potential cardiovascular benefits: A randomized controlled trial 2021 · coffee B · Healthy, nonsmoking coffee drinkers with no history or diagnosis of chronic disease and not taking medications | 407 mg | 8 weeks | 25 |
| Changes in the plasma lipidome of healthy subjects after coffee consumption reveal potential cardiovascular benefits: A randomized controlled trial 2021 · coffee A · Healthy, nonsmoking coffee drinkers with no history or diagnosis of chronic disease and not taking medications | 787 mg | 8 weeks | 24 |
| Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans 2001 · chlorogenic acid · Healthy men and women; age not stated | 2 g | 7 days | 20 |
| Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance 2009 · chlorogenic acid · Healthy, overweight men who were nonsmoking coffee consumers; mean age 39.9 years | 1 g | 1 day | 15 |
| Effect of Chlorogenic Acid Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance 2018 · chlorogenic acid · Patients with impaired glucose tolerance; age and sex not reported | 1.2 g | 12 weeks | 15 |
| Acute Dose-Response Effectiveness of Combined Catechins and Chlorogenic Acids on Postprandial Glycemic Responses in Healthy Men: Results from Two Randomized Studies 2023 · Dose A · Healthy men aged 41 ± 9 years, with normal blood glucose, Study 1 | 270 mg | 1 day | 18 |
| Acute Dose-Response Effectiveness of Combined Catechins and Chlorogenic Acids on Postprandial Glycemic Responses in Healthy Men: Results from Two Randomized Studies 2023 · Dose B · Healthy men aged 41 ± 9 years, with normal blood glucose, Study 1 | 270 mg | 1 day | 18 |
| Acute Dose-Response Effectiveness of Combined Catechins and Chlorogenic Acids on Postprandial Glycemic Responses in Healthy Men: Results from Two Randomized Studies 2023 · Dose C · Healthy men aged 47 ± 11 years, with fasting glucose 95–125 mg/dL, Study 2 | 150 mg | 1 day | 16 |
| Acute Dose-Response Effectiveness of Combined Catechins and Chlorogenic Acids on Postprandial Glycemic Responses in Healthy Men: Results from Two Randomized Studies 2023 · Dose D · Healthy men aged 47 ± 11 years, with fasting glucose 95–125 mg/dL, Study 2 | 300 mg | 1 day | 16 |
| Effects of Ingesting Both Catechins and Chlorogenic Acids on Glucose, Incretin, and Insulin Sensitivity in Healthy Men: A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial 2022 · GTC+CCA-enriched beverage · Healthy men aged 20–60 years | 373 mg | 3 weeks | 11 |
| Coffee Consumption Increases the Antioxidant Capacity of Plasma and Has No Effect on the Lipid Profile or Vascular Function in Healthy Adults in a Randomized Controlled Trial 2016 · Medium-CGA coffee group (MCCGA) · Healthy men and women; mean age 38.5 years | 420 mg | 8 weeks | — |
| Coffee Consumption Increases the Antioxidant Capacity of Plasma and Has No Effect on the Lipid Profile or Vascular Function in Healthy Adults in a Randomized Controlled Trial 2016 · High-CGA coffee group (HCCGA) · Healthy men and women; mean age 38.5 years | 780 mg | 8 weeks | — |
| Acute reduction of serum 8-iso-PGF2-alpha and advanced oxidation protein products in vivo by a polyphenol-rich beverage; a pilot clinical study with phytochemical and in vitro antioxidant characterization 2011 · PRB group · Males and females aged 45–55 years with BMI 25–36, reporting themselves healthy and without known disease conditions | 225 mg | 1 day | 16 |
| Effect of Blueberin on fasting glucose, C-reactive protein and plasma aminotransferases, in female volunteers with diabetes type 2: double-blind, placebo controlled clinical study 2006 · Blueberin group · Female volunteers aged 46 ± 15 years with type 2 diabetes | 150 mg | 4 weeks | — |
