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Chlorogenic Acid and Caffeine: study protocols

12 study groups took Chlorogenic Acid together with Caffeine. These are the doses the studies gave. They are not a recommendation.

Chlorogenic Acid: what the research found →

Dose per serving from research: Chlorogenic Acid

12 study groups in 6 studies say how much Chlorogenic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mg to 500 mg, 67% of 12 study groups.

Daily doseStudy groups
100 mg or less
1
100 mg to 250 mg
1
250 mg to 500 mg
8
500 mg to 1 g
1
over 1 g
1

Dose per serving from research: Caffeine

10 study groups in 5 studies say how much Caffeine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 mg to 250 mg, 60% of 10 study groups.

Daily doseStudy groups
50 mg or less
1
50 mg to 100 mg
2
100 mg to 250 mg
6
250 mg to 500 mg
1

Commonly used together

6 of 12 study groups took Chlorogenic Acid and Caffeine with something else, but nothing that 3 or more different studies gave.

12 study groups

Study
Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials
2017 · coffee with 89 mg CGA · healthy adult men; age not stated
89 mg—1 day—
Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials
2017 · coffee with 310 mg CGA · healthy adult men; age not stated
310 mg—1 day—
Consumption of a Coffee Rich in Phenolic Compounds May Improve the Body Composition of People with Overweight or Obesity: Preliminary Insights from a Randomized, Controlled and Blind Crossover Study
2024 · Lightly roasted coffee (LRC) · Adults aged 18–65 with overweight or obesity (BMI 25.0–35.0 kg/m²)
1.2 g390 mg12 weeks—
Consumption of a Coffee Rich in Phenolic Compounds May Improve the Body Composition of People with Overweight or Obesity: Preliminary Insights from a Randomized, Controlled and Blind Crossover Study
2024 · Commercial roasted coffee (RC) · Adults aged 18–65 with overweight or obesity (BMI 25.0–35.0 kg/m²)
450 mg210 mg12 weeks—
A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans
2020 · Coffee berry extract beverage · Healthy adults aged 18–35 years, males and females
440 mg22 mg1 day32
Acute Dose-Response Effectiveness of Combined Catechins and Chlorogenic Acids on Postprandial Glycemic Responses in Healthy Men: Results from Two Randomized Studies
2023 · Dose A · Healthy men aged 41 ± 9 years, with normal blood glucose, Study 1
270 mg113 mg1 day18
Acute Dose-Response Effectiveness of Combined Catechins and Chlorogenic Acids on Postprandial Glycemic Responses in Healthy Men: Results from Two Randomized Studies
2023 · Dose B · Healthy men aged 41 ± 9 years, with normal blood glucose, Study 1
270 mg113 mg1 day18
Acute Dose-Response Effectiveness of Combined Catechins and Chlorogenic Acids on Postprandial Glycemic Responses in Healthy Men: Results from Two Randomized Studies
2023 · Dose C · Healthy men aged 47 ± 11 years, with fasting glucose 95–125 mg/dL, Study 2
150 mg99 mg1 day16
Acute Dose-Response Effectiveness of Combined Catechins and Chlorogenic Acids on Postprandial Glycemic Responses in Healthy Men: Results from Two Randomized Studies
2023 · Dose D · Healthy men aged 47 ± 11 years, with fasting glucose 95–125 mg/dL, Study 2
300 mg99 mg1 day16
Effects of Ingesting Both Catechins and Chlorogenic Acids on Glucose, Incretin, and Insulin Sensitivity in Healthy Men: A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial
2022 · GTC+CCA-enriched beverage · Healthy men aged 20–60 years
373 mg119 mg3 weeks11
Coffee Consumption Increases the Antioxidant Capacity of Plasma and Has No Effect on the Lipid Profile or Vascular Function in Healthy Adults in a Randomized Controlled Trial
2016 · Medium-CGA coffee group (MCCGA) · Healthy men and women; mean age 38.5 years
420 mg193 mg8 weeks—
Coffee Consumption Increases the Antioxidant Capacity of Plasma and Has No Effect on the Lipid Profile or Vascular Function in Healthy Adults in a Randomized Controlled Trial
2016 · High-CGA coffee group (HCCGA) · Healthy men and women; mean age 38.5 years
780 mg193 mg8 weeks—
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